Aliases & Classifications for Funisitis

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Funisitis, Aliases & Descriptions:

Name: Funisitis 9 11 60


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Disease Ontology9 DOID:0050698

Summaries for Funisitis

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Wikipedia:63 Funisitis is inflammation of the connective tissue of the umbilical cord, which may cause abortion. more...

MalaCards based summary: Funisitis is related to chorioamnionitis and cervical incompetence. An important gene associated with Funisitis is MMP8 (matrix metallopeptidase 8 (neutrophil collagenase)), and among its related pathways are Validated transcriptional targets of AP1 family members Fra1 and Fra2 and Immune response MIF mediated glucocorticoid regulation. The compounds cdp571 and ulinastatin have been mentioned in the context of this disorder. Affiliated tissues include placenta, testes and lung, and related mouse phenotypes are tumorigenesis and skeleton.

Disease Ontology:9 A connective tissue disease that is an inflammation of the connective tissue of the umbilical cord.

Related Diseases for Funisitis

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Diseases related to Funisitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 96)
idRelated DiseaseScoreTop Affiliating Genes
1chorioamnionitis30.0S100A12, CRP, IL1B, IL6, IL8, MMP8
2cervical incompetence10.5SERPINH1
3bronchiolitis10.5IL8
4muckle-wells syndrome10.4IL1B
5intervertebral disc disease10.4IL1B
6blau syndrome10.4IL1B
7bacteriuria10.4CRP
8aortic aneurysm10.4CRP
9arteriosclerosis10.4ANGPT1
10psoriatic arthritis10.3CRP
11bronchiolitis obliterans10.3IL8, MMP8
12cholesteatoma10.3S100A8, MMP8
13gastritis10.3S100A8, IL8
14duodenal ulcer10.3S100A8, IL8
15keloids10.3MMP8, SERPINH1
16bronchiectasis10.3MMP8, IL8
17congenital syphilis10.3
18syphilis10.3
19gastric ulcer10.3ANGPT1, S100A8
20peptic ulcer disease10.3IL8, S100A8
21bronchitis10.2S100A8, IL8
22gingivitis10.2IL1B, MMP8
23spondylarthropathy10.2S100A8, CRP
24reactive arthritis10.2MMP8, CRP
25kawasaki disease10.2CRP, S100A12
26euthyroid sick syndrome10.2IL1B, IL6
27myasthenic syndrome, slow-channel congenital10.2IL8, CRP
28crohn's disease10.2CRP
29mastitis10.2IL8, IL1B
30poems syndrome10.2IL1B, IL6
31periodontal disease10.2IL6, CRP
32bronchopulmonary dysplasia10.2
33vasculitis10.2
34factor v leiden thrombophilia10.2ANGPT1, S100A8, MMP8
35adult-onset still's disease10.1IL6, CRP
36microvascular complications of diabetes 110.1IL8, ANGPT1
37familial mediterranean fever, ar10.1CRP, IL1B
38periodontitis10.1IL1B, MMP8, IL8
39bacterial vaginosis10.1SERPINH1, IL8, IL1B
40alcoholic hepatitis10.1IL10, IL8
41pulmonary fibrosis, idiopathic10.1IL8, IL1B, SERPINH1
42pulmonary fibrosis10.1IL1B, IL8, SERPINH1
43acute myocardial infarction10.1MMP8, CRP, ANGPT1
44behcet's disease10.1CRP, IL8
45acquired immunodeficiency syndrome10.0IL6, IL1B
46metabolic acidosis10.0
47candidiasis10.0
48herpes simplex10.0
49endotheliitis10.0
50juvenile rheumatoid arthritis10.0IL6, S100A8, CRP

Graphical network of the top 20 diseases related to Funisitis:



Diseases related to funisitis

Symptoms for Funisitis

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Drugs & Therapeutics for Funisitis

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Drug clinical trials:

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Genetic Tests for Funisitis

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Anatomical Context for Funisitis

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MalaCards organs/tissues related to Funisitis:

31
Placenta, Testes, Lung, Endothelial, Neutrophil

Animal Models for Funisitis or affiliated genes

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MGI Mouse Phenotypes related to Funisitis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.3MMP8, IL10, IL6, IL1B, COL18A1
2MP:00053908.2SERPINH1, IL10, IL6, IL1B, COL18A1
3MP:00036318.0COL18A1, IL1B, IL6, IL10, ANGPT1, SERPINH1
4MP:00053857.6CRP, COL18A1, IL1B, IL6, IL10, ANGPT1
5MP:00053877.5MMP8, IL10, IL8, IL6, IL1B, CRP

Publications for Funisitis

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Articles related to Funisitis:

(show top 50)    (show all 63)
idTitleAuthorsYear
1
A fetal and an intra-amniotic inflammatory response is more severe in preterm labor than in preterm PROM in the context of funisitis: unexpected observation in human gestations. (23658737)
2013
2
Low level of tracheal cellular fibronectin in extremely premature infants with funisitis: Relationship with respiratory distress 1 month after birth. (24155097)
2013
3
Postnatal changes of cytokines in premature infants with or without funisitis. (24246233)
2013
4
Expression of angiogenesis-related factors and inflammatory cytokines in placenta and umbilical vessels in pregnancies with preeclampsia and chorioamnionitis/funisitis. (22639995)
2012
5
Pulsation of the fetal splenic vein--a potential ultrasound marker of histological chorioamnionitis and funisitis in women with preterm prelabor rupture of membranes. (22574855)
2012
6
A prediction model of histological chorioamnionitis and funisitis in preterm prelabor rupture of membranes: analyses of multiple proteins in the amniotic fluid. (22372866)
2012
7
Relationship between maternal serum C-reactive protein, funisitis and early-onset neonatal sepsis. (22690100)
2012
8
Maternal C-reactive protein at hospital admission is a simple predictor of funisitis in preterm premature rupture of membranes. (22710247)
2012
9
Bleeding per vaginam is associated with funisitis in women with preterm prelabour rupture of the fetal membranes. (21392243)
2011
10
Funisitis and risk for the development of neonatal respiratory distress syndrome. (21531459)
2011
11
Correlation between placental histopathology and fetal/neonatal outcome: chorioamnionitis and funisitis are associated to intraventricular haemorrage and retinopathy of prematurity in preterm newborns. (20528214)
2011
12
Neutrophil elastase and interleukin-6 in amniotic fluid as indicators of chorioamnionitis and funisitis. (21645958)
2011
13
Prolonged fetal bradycardia as the presenting clinical sign in congenital syphilis complicated by necrotizing funisitis: a case report. (21766037)
2011
14
The frequency and risk factors of funisitis and histologic chorioamnionitis in pregnant women at term who delivered after the spontaneous onset of labor. (20698737)
2011
15
Funisitis and chorionic vasculitis: relation to chorioamnionitis, timing and scoring. (22059462)
2011
16
Soluble receptor for advanced glycation end products (sRAGE) in tracheobronchial aspirate fluid and cord blood of very low birth weight infants with chorioamnionitis and funisitis. (20727688)
2010
17
Airway concentrations of angiopoietin-1 and endostatin in ventilated extremely premature infants are decreased after funisitis and unbalanced with bronchopulmonary dysplasia/death. (19127216)
2009
18
Dermatophilus congolensis-associated placentitis, funisitis and abortion in a horse. (18405341)
2008
19
Increased numbers of macrophages in tracheal aspirates in premature infants with funisitis. (18353056)
2008
20
The antenatal identification of funisitis with a rapid MMP-8 bedside test. (19127606)
2008
21
Induction of necrotizing funisitis by fetal administration of intravenous granulocyte-colony stimulating factor and intra-amniotic endotoxin in premature fetal sheep. (17957156)
2007
22
Umbilical cord hematoma: association with chorioamnionitis and funisitis. (17611840)
2007
23
Proteomic biomarkers of intra-amniotic inflammation: relationship with funisitis and early-onset sepsis in the premature neonate. (17314690)
2007
24
Ureaplasma urealyticum and Mycoplasma hominis presence in umbilical cord is associated with pathogenesis of funisitis. (18204300)
2007
25
The value of cord blood interleukin-6 levels for predicting chorioamnionitis, funisitis and neonatal infection in term premature rupture of membranes. (16459014)
2006
26
Congenital cutaneous candidiasis with funisitis. (15781940)
2005
27
Funisitis associated with leptospiral abortion in an equine placenta. (16145212)
2005
28
Activation of umbilical cord endothelial cells and fetal inflammatory response in preterm infants with chorioamnionitis and funisitis. (15611353)
2005
29
Are histopathologic chorioamnionitis and funisitis associated with metabolic acidosis in the preterm fetus? (15592284)
2004
30
Chorioamnionitis/funisitis and the development of bronchopulmonary dysplasia. (15228562)
2004
31
C-reactive protein in umbilical cord blood: a simple and widely available clinical method to assess the risk of amniotic fluid infection and funisitis. (14629087)
2003
32
Funisitis and chorionic vasculitis: the histological counterpart of the fetal inflammatory response syndrome. (12380603)
2002
33
Meconium-stained amniotic fluid and neonatal morbidity in near-term and term deliveries with acute histologic chorioamnionitis and/or funisitis. (11774015)
2001
34
The relationship between amniotic fluid matrix metalloproteinase-8 and funisitis. (11717650)
2001
35
Acute funisitis of preterm but not term placentas is associated with severe fetal inflammatory response. (11431717)
2001
36
Association between funisitis and elevated interleukin-6 in cord blood. (11165585)
2001
37
Testing umbilical cords for funisitis due to Treponema pallidum infection, Bolivia. (10998379)
2000
38
The relationship among inflammatory lesions of the umbilical cord (funisitis), umbilical cord plasma interleukin 6 concentration, amniotic fluid infection, and neonatal sepsis. (11084553)
2000
39
The role of low molecular weight hyaluronic acid contained in Wharton's jelly in necrotizing funisitis. (10203142)
1999
40
Necrotizing funisitis: clinical significance and association with chronic lung disease in premature infants. (9423742)
1997
41
Necrotizing funisitis associated with Actinomyces meyeri infection: a case report. (7855012)
1994
42
Necrotizing funisitis and herpes simplex infection of placental and decidual tissues: study of four cases. (8026831)
1994
43
Necrotizing funisitis: a study of 45 cases. (1427754)
1992
44
Necrotizing funisitis. (1727589)
1992
45
Candida albicans placentitis and funisitis: early diagnosis of congenital candidemia by histopathologic examination of umbilical cord vessels. (2235191)
1990
46
Congenital syphilis and necrotizing funisitis. (2754789)
1989
47
Congenital syphilis and necrotizing funisitis. (2918676)
1989
48
Chorioamnionitis and funisitis due to Corynebacterium kutscheri. (518110)
1979
49
Chronic viral funisitis. (925832)
1977
50
Subacute necrotizing funisitis. A variant of cord inflammation with a high rate of perinatal infection. (4418774)
1974

Variations for Funisitis

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Expression for genes affiliated with Funisitis

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Search GEO for disease gene expression data for Funisitis.

Pathways for genes affiliated with Funisitis

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Pathways related to Funisitis according to GeneCards Suite gene sharing:

(show all 40)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7IL6, IL8
29.7IL6, IL8
39.7IL6, IL8
49.6CRP, IL6
5
Show member pathways
9.6COL18A1, MMP8, SERPINH1
69.4IL6, IL1B
79.4IL1B, IL6
8
Show member pathways
Immune response MIF in innate immunity response58
9.1IL1B, IL6, IL8
9
Show member pathways
9.1IL1B, IL6, IL8
109.1IL1B, IL6, IL8
11
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
9.1IL1B, IL6, IL8
12
Show member pathways
9.1IL1B, IL6, IL8
13
Show member pathways
9.1IL1B, IL6, IL8
14
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
9.1IL8, IL6, IL1B
159.1IL8, IL6, IL1B
169.1IL8, IL6, IL1B
17
Show member pathways
thioredoxin pathway36
9.0CRP, IL1B, IL6
188.9IL10, IL6, IL1B
198.9IL10, IL6, IL1B
208.9IL10, IL6, IL1B
21
Show member pathways
8.9IL10, IL6, IL1B
22
Show member pathways
IL27-mediated signaling events36
8.9IL10, IL6, IL1B
238.9IL10, IL6, IL1B
24
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
8.9IL1B, IL6, IL10
25
Show member pathways
8.9IL1B, IL6, IL10
268.7IL1B, IL6, IL8, ANGPT1
27
Show member pathways
8.6IL6, IL1B, S100A12
28
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
8.6IL1B, IL6, IL10, ANGPT1
298.5IL10, IL8, IL6, IL1B
308.5IL10, IL8, IL6, IL1B
318.5IL10, IL8, IL6, IL1B
32
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.5IL10, IL8, IL6, IL1B
338.5IL1B, IL6, IL8, IL10
348.5IL1B, IL6, IL8, IL10
35
Show member pathways
8.2ANGPT1, IL10, IL8, IL6, IL1B
36
Show member pathways
8.2ANGPT1, IL10, IL8, IL6, IL1B
37
Show member pathways
8.2ANGPT1, IL10, IL8, IL6, IL1B
38
Show member pathways
8.2ANGPT1, IL10, IL8, IL6, IL1B
39
Show member pathways
7.9ANGPT1, IL10, IL8, IL6, IL1B, COL18A1

Compounds for genes affiliated with Funisitis

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Compounds related to Funisitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 133)
idCompoundScoreTop Affiliating Genes
1cdp571439.5CRP, IL10, IL6
2ulinastatin439.4IL10, IL8, IL6
3turpentine439.4IL6, CRP, IL1B
4mcp 1439.4IL8, IL6, IL10
5taurine chloramine439.4IL6, IL1B, IL8
6echinacea439.4IL10, IL8, IL1B
7bucillamine439.3IL6, CRP, IL1B
8hbd2439.3IL8, IL6, IL1B
9tenidap43 2810.3CRP, IL1B, IL6
10anakinra43 1210.3CRP, IL1B, IL6
11azithromycin43 1210.3IL10, IL8, CRP
12monosodium urate439.3IL1B, IL8, S100A8
13pamidronate43 49 1211.2IL6, CRP, IL10
14toxin-1439.2IL1B, IL8, IL10
15olopatadine43 1210.2IL8, S100A12, IL6
16gabexate mesilate439.2CRP, IL6, IL8, IL10
178-isoprostane439.1IL10, CRP, IL8, IL6
18clodronate43 49 1211.1IL1B, MMP8, IL10, IL6
19mip 1alpha439.0IL1B, IL8, IL10, IL6
20il-12439.0IL8, IL6, IL1B, IL10
21polymyxin b439.0IL10, IL1B, IL6, IL8
22groalpha439.0IL6, IL1B, IL10, IL8
23gm-csf43 2810.0IL10, IL8, IL6, IL1B
24lipoteichoic acid439.0IL8, IL10, IL6, IL1B
25flagellin43 2810.0IL1B, IL8, S100A8
26polyinosinic-polycytidylic acid438.9IL1B, IL6, IL8, IL10
27il 10438.9IL1B, IL8, IL6, IL10
28peptidoglycan43 289.9IL8, IL6, IL1B, IL10
29as 10143 599.9IL10, IL1B, S100A8
30ccl343 289.9IL1B, IL6, IL10, IL8
31pentoxifylline43 129.9IL10, IL6, IL1B, IL8
3215-deoxy-delta-12,14-prostaglandin j2438.9IL6, IL8, IL10, IL1B
335 aminosalicylic acid438.9IL1B, IL8, IL10
34infliximab43 49 1210.8IL10, IL6, IL1B, CRP
35adalimumab43 49 1210.8IL6, CRP, IL10
36thalidomide43 49 59 1211.7IL10, IL6, IL1B, S100A8
37cyclosporin a43 28 5910.6IL6, IL8, IL10, SERPINH1, ANGPT1, MMP8
38hydrocortisone43 2 59 1211.6IL6, IL8, IL1B, IL10
39etanercept43 49 1210.5IL10, IL8, IL6, IL1B, CRP
40neopterin438.5IL6, IL1B, CRP, IL8, IL10
41sb 20358043 599.4IL6, IL8, IL10, IL1B, CRP
42rantes438.4IL1B, IL6, IL8, IL10, S100A8
43methotrexate49 43 1210.3IL1B, S100A8, IL10, IL6, CRP
44pge2438.3IL8, MMP8, IL1B, IL10, IL6
45histamine43 28 2410.2S100A8, IL8, IL1B, IL10, IL6
46ly294002438.2IL1B, IL6, IL8, IL10, ANGPT1, CRP
47ivig438.1S100A12, IL6, IL10, CRP, IL1B
48endotoxin438.0IL8, IL6, IL1B, CRP, S100A8, IL10
49vegf437.6ANGPT1, CRP, IL1B, IL6, IL8, IL10
50nitric oxide43 24 129.5SERPINH1, MMP8, ANGPT1, IL10, IL8, IL6

GO Terms for genes affiliated with Funisitis

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Cellular components related to Funisitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055766.3ANGPT1, IL8, IL6, IL1B, COL18A1, CRP
2extracellular spaceGO:00056156.0S100A8, SERPINH1, MMP8, ANGPT1, IL10, IL8

Biological processes related to Funisitis according to GeneCards Suite gene sharing:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of lipid storageGO:00108889.9CRP, IL6
2response to molecule of bacterial originGO:00022379.9IL10, IL8
3defense response to Gram-positive bacteriumGO:00508309.8IL6, CRP
4acute-phase responseGO:00069539.8CRP, IL6
5positive regulation of peptidyl-serine phosphorylationGO:00331389.7IL6, ANGPT1
6positive regulation of nitric oxide biosynthetic processGO:00454299.7IL1B, IL6
7extracellular matrix organizationGO:00301989.6COL18A1, MMP8, SERPINH1
8positive regulation of interleukin-6 productionGO:00327559.6IL1B, IL6
9monocyte chemotaxisGO:00025489.5S100A12, IL6
10positive regulation of T cell proliferationGO:00421029.4IL1B, IL6
11defense response to fungusGO:00508329.4S100A8, S100A12
12response to drugGO:00424939.3IL10, IL6, COL18A1
13response to insulinGO:00328689.2IL6, IL10
14positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.2IL1B, IL6, IL10
15negative regulation of cell proliferationGO:00082859.0IL8, IL6, IL1B, COL18A1
16positive regulation of inflammatory responseGO:00507299.0S100A12, S100A8
17defense response to bacteriumGO:00427428.9S100A8, S100A12, IL10
18neutrophil chemotaxisGO:00305938.5S100A8, S100A12, IL1B, IL8
19positive regulation of NF-kappaB transcription factor activityGO:00510928.4IL6, IL1B, S100A12, S100A8
20inflammatory responseGO:00069547.1S100A8, IL10, IL8, IL6, IL1B, CRP

Molecular functions related to Funisitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051258.9IL1B, IL6, IL10
2RAGE receptor bindingGO:00507868.8S100A8, S100A12

Products for genes affiliated with Funisitis

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Sources for Funisitis

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3CDC
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25ICD10
26ICD10 via Orphanet
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29KEGG
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