MCID: FNS001
MIFTS: 44

Funisitis malady

Summaries for Funisitis

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Wikipedia:66 Funisitis is inflammation of the connective tissue of the umbilical cord, which may cause abortion. more...

MalaCards: Funisitis is related to chorioamnionitis and sepsis. An important gene associated with Funisitis is MMP8 (matrix metallopeptidase 8 (neutrophil collagenase)), and among its related pathways are Validated transcriptional targets of AP1 family members Fra1 and Fra2 and TSLP Signaling Pathway. The compounds cdp571 and ulinastatin have been mentioned in the context of this disorder. Affiliated tissues include placenta, testes and lung, and related mouse phenotypes are tumorigenesis and skeleton.

Disease Ontology:9 A connective tissue disease that is an inflammation of the connective tissue of the umbilical cord.

Aliases & Classifications for Funisitis

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9Disease Ontology, 11DISEASES, 63UMLS
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Aliases & Descriptions:

funisitis 9 11 63


External Ids:

Disease Ontology9 DOID:0050698

Related Diseases for Funisitis

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18GeneCards, 19GeneDecks
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Diseases related to Funisitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 100)
idRelated DiseaseScoreTop Affiliating Genes
1chorioamnionitis30.7S100A12, CRP, IL1B, IL6, IL8, MMP8
2sepsis30.0S100A8, IL1B, CRP, IL8, IL10, ANGPT1
3congenital syphilis10.2
4syphilis10.2
5bronchopulmonary dysplasia10.2
6cervical incompetence10.1SERPINH1
7bronchiolitis10.1IL8
8muckle-wells syndrome10.1IL1B
9degenerative disc disease10.1IL1B
10blau syndrome10.1IL1B
11bacteriuria10.1CRP
12aortic aneurysm10.1CRP
13arteriosclerosis10.1ANGPT1
14malaria10.1IL10
15psoriatic arthritis10.1CRP
16bronchiolitis obliterans10.1IL8, MMP8
17cholesteatoma10.1S100A8, MMP8
18gastritis10.1S100A8, IL8
19duodenal ulcer10.1S100A8, IL8
20keloids10.1MMP8, SERPINH1
21bronchiectasis10.1MMP8, IL8
22gastric ulcer10.1ANGPT1, S100A8
23peptic ulcer disease10.1IL8, S100A8
24bronchitis10.1S100A8, IL8
25gingivitis10.1IL1B, MMP8
26spondylarthropathy10.1S100A8, CRP
27reactive arthritis10.1MMP8, CRP
28kawasaki disease10.1CRP, S100A12
29euthyroid sick syndrome10.0IL1B, IL6
30slow-channel congenital myasthenic syndrome10.0IL8, CRP
31crohn's disease10.0CRP
32mastitis10.0IL8, IL1B
33poems syndrome10.0IL1B, IL6
34periodontal disease10.0IL6, CRP
35factor v leiden thrombophilia10.0ANGPT1, S100A8, MMP8
36adult-onset still's disease10.0IL6, CRP
37proliferative diabetic retinopathy10.0IL8, ANGPT1
38familial mediterranean fever10.0CRP, IL1B
39periodontitis10.0IL1B, MMP8, IL8
40bacterial vaginosis10.0SERPINH1, IL8, IL1B
41alcoholic hepatitis10.0IL10, IL8
42idiopathic pulmonary fibrosis10.0IL8, IL1B, SERPINH1
43pulmonary fibrosis10.0IL1B, IL8, SERPINH1
44acute myocardial infarction10.0MMP8, CRP, ANGPT1
45behcet's disease10.0CRP, IL8
46acquired immunodeficiency syndrome10.0IL6, IL1B
47juvenile rheumatoid arthritis10.0IL6, S100A8, CRP
48arthropathy10.0S100A8, IL1B, CRP
49metabolic acidosis10.0
50retinopathy of prematurity10.0

Graphical network of the top 20 diseases related to Funisitis:



Diseases related to funisitis

Symptoms for Funisitis

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Drugs & Therapeutics for Funisitis

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Funisitis

Drug clinical trials:

Search ClinicalTrials for Funisitis

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Genetic Tests for Funisitis

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Anatomical Context for Funisitis

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34MalaCards
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MalaCards organs/tissues related to Funisitis:

34
Placenta, Testes, Lung, Endothelial

Animal Models for Funisitis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Funisitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.3MMP8, COL18A1, IL1B, IL6, IL10
2MP:00053908.2COL18A1, IL1B, IL6, IL10, SERPINH1
3MP:00036318.0IL1B, SERPINH1, ANGPT1, COL18A1, IL6, IL10
4MP:00053857.6COL18A1, SERPINH1, ANGPT1, IL10, IL6, CRP
5MP:00053877.5IL1B, IL6, MMP8, CRP, IL8, IL10

Publications for Funisitis

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53PubMed
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Articles related to Funisitis:

(show top 50)    (show all 60)
idTitleAuthorsYear
1
A fetal and an intra-amniotic inflammatory response is more severe in preterm labor than in preterm PROM in the context of funisitis: unexpected observation in human gestations. (23658737)
2013
2
Low level of tracheal cellular fibronectin in extremely premature infants with funisitis: Relationship with respiratory distress 1 month after birth. (24155097)
2013
3
Postnatal changes of cytokines in premature infants with or without funisitis. (24246233)
2013
4
The association between histological chorioamnionitis, funisitis and neonatal outcome in women with preterm prelabor rupture of membranes. (23489073)
2013
5
Expression of angiogenesis-related factors and inflammatory cytokines in placenta and umbilical vessels in pregnancies with preeclampsia and chorioamnionitis/funisitis. (22639995)
2012
6
Pulsation of the fetal splenic vein--a potential ultrasound marker of histological chorioamnionitis and funisitis in women with preterm prelabor rupture of membranes. (22574855)
2012
7
A prediction model of histological chorioamnionitis and funisitis in preterm prelabor rupture of membranes: analyses of multiple proteins in the amniotic fluid. (22372866)
2012
8
Relationship between maternal serum C-reactive protein, funisitis and early-onset neonatal sepsis. (22690100)
2012
9
Bleeding per vaginam is associated with funisitis in women with preterm prelabour rupture of the fetal membranes. (21392243)
2011
10
Funisitis and risk for the development of neonatal respiratory distress syndrome. (21531459)
2011
11
Correlation between placental histopathology and fetal/neonatal outcome: chorioamnionitis and funisitis are associated to intraventricular haemorrage and retinopathy of prematurity in preterm newborns. (20528214)
2011
12
Neutrophil elastase and interleukin-6 in amniotic fluid as indicators of chorioamnionitis and funisitis. (21645958)
2011
13
Prolonged fetal bradycardia as the presenting clinical sign in congenital syphilis complicated by necrotizing funisitis: a case report. (21766037)
2011
14
The frequency and risk factors of funisitis and histologic chorioamnionitis in pregnant women at term who delivered after the spontaneous onset of labor. (20698737)
2011
15
Funisitis and chorionic vasculitis: relation to chorioamnionitis, timing and scoring. (22059462)
2011
16
Soluble receptor for advanced glycation end products (sRAGE) in tracheobronchial aspirate fluid and cord blood of very low birth weight infants with chorioamnionitis and funisitis. (20727688)
2010
17
Airway concentrations of angiopoietin-1 and endostatin in ventilated extremely premature infants are decreased after funisitis and unbalanced with bronchopulmonary dysplasia/death. (19127216)
2009
18
Dermatophilus congolensis-associated placentitis, funisitis and abortion in a horse. (18405341)
2008
19
Increased numbers of macrophages in tracheal aspirates in premature infants with funisitis. (18353056)
2008
20
The antenatal identification of funisitis with a rapid MMP-8 bedside test. (19127606)
2008
21
Induction of necrotizing funisitis by fetal administration of intravenous granulocyte-colony stimulating factor and intra-amniotic endotoxin in premature fetal sheep. (17957156)
2007
22
Umbilical cord hematoma: association with chorioamnionitis and funisitis. (17611840)
2007
23
Proteomic biomarkers of intra-amniotic inflammation: relationship with funisitis and early-onset sepsis in the premature neonate. (17314690)
2007
24
Ureaplasma urealyticum and Mycoplasma hominis presence in umbilical cord is associated with pathogenesis of funisitis. (18204300)
2007
25
The value of cord blood interleukin-6 levels for predicting chorioamnionitis, funisitis and neonatal infection in term premature rupture of membranes. (16459014)
2006
26
Congenital cutaneous candidiasis with funisitis. (15781940)
2005
27
Funisitis associated with leptospiral abortion in an equine placenta. (16145212)
2005
28
Activation of umbilical cord endothelial cells and fetal inflammatory response in preterm infants with chorioamnionitis and funisitis. (15611353)
2005
29
Are histopathologic chorioamnionitis and funisitis associated with metabolic acidosis in the preterm fetus? (15592284)
2004
30
Chorioamnionitis/funisitis and the development of bronchopulmonary dysplasia. (15228562)
2004
31
C-reactive protein in umbilical cord blood: a simple and widely available clinical method to assess the risk of amniotic fluid infection and funisitis. (14629087)
2003
32
Meconium-stained amniotic fluid and neonatal morbidity in near-term and term deliveries with acute histologic chorioamnionitis and/or funisitis. (11774015)
2001
33
The relationship between amniotic fluid matrix metalloproteinase-8 and funisitis. (11717650)
2001
34
Acute funisitis of preterm but not term placentas is associated with severe fetal inflammatory response. (11431717)
2001
35
Association between funisitis and elevated interleukin-6 in cord blood. (11165585)
2001
36
Testing umbilical cords for funisitis due to Treponema pallidum infection, Bolivia. (10998379)
2000
37
The relationship among inflammatory lesions of the umbilical cord (funisitis), umbilical cord plasma interleukin 6 concentration, amniotic fluid infection, and neonatal sepsis. (11084553)
2000
38
The role of low molecular weight hyaluronic acid contained in Wharton's jelly in necrotizing funisitis. (10203142)
1999
39
Necrotizing funisitis with intrapartum umbilical cord rupture. (10685250)
1999
40
Necrotizing funisitis: clinical significance and association with chronic lung disease in premature infants. (9423742)
1997
41
Necrotizing funisitis associated with Actinomyces meyeri infection: a case report. (7855012)
1994
42
Necrotizing funisitis and herpes simplex infection of placental and decidual tissues: study of four cases. (8026831)
1994
43
Necrotizing funisitis: a study of 45 cases. (1427754)
1992
44
Necrotizing funisitis. (1727589)
1992
45
Candida albicans placentitis and funisitis: early diagnosis of congenital candidemia by histopathologic examination of umbilical cord vessels. (2235191)
1990
46
Congenital syphilis and necrotizing funisitis. (2754789)
1989
47
Congenital syphilis and necrotizing funisitis. (2918676)
1989
48
Chorioamnionitis and funisitis due to Corynebacterium kutscheri. (518110)
1979
49
Chronic viral funisitis. (925832)
1977
50
Subacute necrotizing funisitis. A variant of cord inflammation with a high rate of perinatal infection. (4418774)
1974

Variations for Funisitis

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Expression for genes affiliated with Funisitis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Funisitis

Search GEO for disease gene expression data for Funisitis.

Pathways for genes affiliated with Funisitis

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Sources:
51PathCards, 39NCBI BioSystems Database, 61Thomson Reuters, 56Reactome, 55R&D Systems, 31KEGG, 54QIAGEN, 13EMD Millipore
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Pathways related to Funisitis according to GeneCards/GeneDecks:

(show all 40)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7IL6, IL8
29.7IL8, IL6
39.7IL8, IL6
49.6CRP, IL6
5
Show member pathways
9.6MMP8, COL18A1, SERPINH1
69.4IL6, IL1B
79.4IL6, IL1B
8
Show member pathways
Immune response MIF in innate immunity response61
9.1IL6, IL1B, IL8
99.1IL6, IL1B, IL8
109.1IL1B, IL6, IL8
11
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
9.1IL1B, IL6, IL8
12
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways61
Immune response IL 1 signaling pathway61
9.1IL1B, IL6, IL8
13
Show member pathways
9.1IL8, IL6, IL1B
149.1IL8, IL6, IL1B
15
Show member pathways
9.1IL8, IL6, IL1B
169.1IL8, IL6, IL1B
17
Show member pathways
9.1IL8, IL6, IL1B
18
Show member pathways
thioredoxin pathway39
9.0CRP, IL6, IL1B
198.9IL6, IL10, IL1B
208.9IL6, IL10, IL1B
21
Show member pathways
8.9IL6, IL1B, IL10
228.9IL1B, IL10, IL6
23
Show member pathways
IL27-mediated signaling events39
8.9IL1B, IL6, IL10
24
Show member pathways
8.9IL10, IL1B, IL6
258.9IL1B, IL6, IL10
26
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
8.9IL1B, IL10, IL6
278.7ANGPT1, IL8, IL6, IL1B
28
Show member pathways
8.6IL6, IL1B, S100A12
29
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
8.6ANGPT1, IL10, IL6, IL1B
308.5IL10, IL8, IL6, IL1B
318.5IL6, IL1B, IL8, IL10
328.5IL10, IL8, IL6, IL1B
33
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
8.5IL8, IL10, IL1B, IL6
348.5IL1B, IL6, IL10, IL8
358.5IL1B, IL8, IL10, IL6
36
Show member pathways
8.2IL6, IL10, ANGPT1, IL1B, IL8
37
Show member pathways
8.2IL6, ANGPT1, IL1B, IL10, IL8
38
Show member pathways
8.2ANGPT1, IL10, IL8, IL6, IL1B
39
Show member pathways
8.2IL1B, IL6, ANGPT1, IL8, IL10
40
Show member pathways
7.9COL18A1, IL1B, IL6, ANGPT1, IL8, IL10

Compounds for genes affiliated with Funisitis

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Sources:
46Novoseek, 30IUPHAR, 12DrugBank, 52PharmGKB, 62Tocris Bioscience, 3BitterDB, 25HMDB
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Compounds related to Funisitis according to GeneCards/GeneDecks:

(show top 50)    (show all 133)
idCompoundScoreTop Affiliating Genes
1cdp571469.5CRP, IL10, IL6
2ulinastatin469.4IL10, IL8, IL6
3turpentine469.4IL6, CRP, IL1B
4mcp 1469.4IL8, IL6, IL10
5taurine chloramine469.4IL6, IL1B, IL8
6echinacea469.4IL10, IL8, IL1B
7bucillamine469.3IL6, CRP, IL1B
8hbd2469.3IL8, IL6, IL1B
9tenidap46 3010.3CRP, IL1B, IL6
10anakinra46 1210.3CRP, IL1B, IL6
11azithromycin46 1210.3IL10, IL8, CRP
12monosodium urate469.3IL1B, IL8, S100A8
13pamidronate46 52 1211.2IL6, CRP, IL10
14toxin-1469.2IL1B, IL8, IL10
15olopatadine46 1210.2IL8, S100A12, IL6
16gabexate mesilate469.2CRP, IL6, IL8, IL10
178-isoprostane469.1IL10, CRP, IL8, IL6
18clodronate46 52 1211.1IL1B, MMP8, IL10, IL6
19mip 1alpha469.0IL1B, IL8, IL10, IL6
20il-12469.0IL8, IL6, IL1B, IL10
21polymyxin b469.0IL10, IL1B, IL6, IL8
22groalpha469.0IL6, IL1B, IL10, IL8
23gm-csf46 3010.0IL10, IL8, IL6, IL1B
24lipoteichoic acid469.0IL8, IL10, IL6, IL1B
25flagellin46 3010.0IL1B, IL8, S100A8
26polyinosinic-polycytidylic acid468.9IL1B, IL6, IL8, IL10
27il 10468.9IL1B, IL8, IL6, IL10
28peptidoglycan46 309.9IL8, IL6, IL1B, IL10
29as 10146 629.9IL10, IL1B, S100A8
30ccl346 309.9IL1B, IL6, IL10, IL8
31pentoxifylline46 129.9IL10, IL6, IL1B, IL8
3215-deoxy-delta-12,14-prostaglandin j2468.9IL6, IL8, IL10, IL1B
335 aminosalicylic acid468.9IL1B, IL8, IL10
34infliximab46 52 1210.8IL10, IL6, IL1B, CRP
35adalimumab46 52 1210.8IL6, CRP, IL10
36thalidomide46 52 62 1211.7IL10, IL6, IL1B, S100A8
37cyclosporin a46 30 6210.6IL6, IL8, IL10, SERPINH1, ANGPT1, MMP8
38hydrocortisone46 3 62 1211.6IL6, IL8, IL1B, IL10
39etanercept46 52 1210.5IL10, IL8, IL6, IL1B, CRP
40neopterin468.5IL6, IL1B, CRP, IL8, IL10
41sb 20358046 629.4IL6, IL8, IL10, IL1B, CRP
42rantes468.4IL1B, IL6, IL8, IL10, S100A8
43methotrexate52 46 1210.3IL1B, S100A8, IL10, IL6, CRP
44pge2468.3IL8, MMP8, IL1B, IL10, IL6
45histamine46 30 2510.2S100A8, IL8, IL1B, IL10, IL6
46ly294002468.2IL1B, IL6, IL8, IL10, ANGPT1, CRP
47ivig468.1S100A12, IL6, IL10, CRP, IL1B
48endotoxin468.0IL8, IL6, IL1B, CRP, S100A8, IL10
49vegf467.6ANGPT1, CRP, IL1B, IL6, IL8, IL10
50nitric oxide46 25 129.5SERPINH1, MMP8, ANGPT1, IL10, IL8, IL6

GO Terms for genes affiliated with Funisitis

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17Gene Ontology
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Cellular components related to Funisitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055766.3MMP8, ANGPT1, IL8, IL6, IL1B, COL18A1
2extracellular spaceGO:0056156.0SERPINH1, MMP8, ANGPT1, IL10, IL8, IL6

Biological processes related to Funisitis according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of lipid storageGO:0108889.9CRP, IL6
2response to molecule of bacterial originGO:0022379.9IL10, IL8
3defense response to Gram-positive bacteriumGO:0508309.8IL6, CRP
4acute-phase responseGO:0069539.8IL6, CRP
5positive regulation of peptidyl-serine phosphorylationGO:0331389.7ANGPT1, IL6
6positive regulation of nitric oxide biosynthetic processGO:0454299.7IL6, IL1B
7extracellular matrix organizationGO:0301989.6SERPINH1, MMP8, COL18A1
8positive regulation of interleukin-6 productionGO:0327559.6IL1B, IL6
9monocyte chemotaxisGO:0025489.5IL6, S100A12
10positive regulation of T cell proliferationGO:0421029.4IL6, IL1B
11defense response to fungusGO:0508329.4S100A12, S100A8
12response to drugGO:0424939.3IL10, IL6, COL18A1
13response to insulinGO:0328689.2IL10, IL6
14positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.2IL1B, IL10, IL6
15negative regulation of cell proliferationGO:0082859.0IL8, IL6, IL1B, COL18A1
16positive regulation of inflammatory responseGO:0507299.0S100A12, S100A8
17defense response to bacteriumGO:0427428.9S100A8, S100A12, IL10
18neutrophil chemotaxisGO:0305938.5S100A8, IL1B, IL8, S100A12
19positive regulation of NF-kappaB transcription factor activityGO:0510928.4IL1B, S100A12, S100A8, IL6
20inflammatory responseGO:0069547.1IL10, IL8, IL6, IL1B, CRP, S100A12

Molecular functions related to Funisitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.9IL1B, IL6, IL10
2RAGE receptor bindingGO:0507868.8S100A8, S100A12

Products for genes affiliated with Funisitis

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  • Antibodies
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Sources for Funisitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet