MCID: FNS001
MIFTS: 37

Funisitis malady

Summaries for Funisitis

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Wikipedia:64 Funisitis is inflammation of the connective tissue of the umbilical cord, which may cause abortion. more...

MalaCards: Funisitis is related to chorioamnionitis and sepsis. An important gene associated with Funisitis is MMP8 (matrix metallopeptidase 8 (neutrophil collagenase)), and among its related pathways are PEDF Induced Signaling and PAK Pathway. The compounds gm-csf and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include lung, placenta and endothelial, and related mouse phenotypes are tumorigenesis and cardiovascular system.

Disease Ontology:8 A connective tissue disease that is an inflammation of the connective tissue of the umbilical cord.

Aliases & Classifications for Funisitis

Sources:
8Disease Ontology, 10DISEASES, 61UMLS
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Aliases & Descriptions:

funisitis 8 10 61


External Ids:

Disease Ontology8 DOID:0050698

Related Diseases for Funisitis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Funisitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 175)
idRelated DiseaseScoreTop Affiliating Genes
1chorioamnionitis30.9S100A12, CRP, IL8, IL1B, IL6, MMP8
2sepsis30.3S100A8, CRP, ANGPT1, IL10, IL8, IL1B
3bronchopulmonary dysplasia30.2IL8
4vasculitis30.2CRP, S100A12
5syphilis10.2
6n syndrome10.1
7metabolic acidosis10.0
8treponema infection10.0
9cerebral palsy10.0MMP8
10esophagitis10.0S100A8
11mixed connective tissue disease10.0S100A8
12dermatomyositis10.0S100A8
13gastroesophageal reflux disease10.0S100A8
14duodenitis10.0S100A8
15lung cancer10.0COL18A1
16periventricular leukomalacia10.0SERPINH1
17sickle cell disease10.0ANGPT1
18sjogren's syndrome10.0S100A8
19ischemia10.0ANGPT1
20ovarian cancer10.0ANGPT1
21bronchiolitis10.0IL8
22arteriosclerosis10.0ANGPT1
23malignant glioma10.0ANGPT1
24endometrial carcinoma10.0ANGPT1
25sarcoidosis10.0IL1B
26interstitial lung disease10.0IL1B
27gingival overgrowth10.0IL1B
28thrombocytopenia10.0IL6
29otitis media10.0IL1B
30cervical incompetence10.0SERPINH1
31pleurisy10.0IL1B
32multiple myeloma10.0IL6
33toxic shock syndrome10.0IL1B
34muckle-wells syndrome10.0IL1B
35degenerative disc disease10.0IL1B
36angiosarcoma10.0ANGPT1
37gout10.0IL1B
38perinatal necrotizing enterocolitis10.0SERPINH1
39uveitis10.0IL10
40kaposi's sarcoma10.0IL6
41malaria10.0IL10
42rhinitis10.0IL8
43myelodysplastic syndromes10.0ANGPT1
44pancreatic cancer10.0IL8
45atopy10.0IL10
46leishmaniasis10.0IL10
47thyroid cancer10.0ANGPT1
48encephalomyelitis10.0IL10
49encephalitis10.0IL1B
50cholesteatoma10.0MMP8, S100A8

Graphical network of the top 20 diseases related to Funisitis:



Diseases related to funisitis

Clinical Features for Funisitis

Drugs & Therapeutics for Funisitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Funisitis

Drug clinical trials:

Search ClinicalTrials for Funisitis

Search NIH Clinical Center for Funisitis

Search CenterWatch for Funisitis

Genetic Tests for Funisitis

Anatomical Context for Funisitis

Sources:
33MalaCards
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MalaCards organs/tissues related to Funisitis:

33
Lung, Placenta, Endothelial, Fetal lung

Animal Models for Funisitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Funisitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.4MMP8, IL6, IL1B, IL10, COL18A1
2MP:00053857.2SERPINH1, COL18A1, CRP, ANGPT1, IL10, IL1B

Publications for Funisitis

Sources:
51PubMed
See all sources

Articles related to Funisitis:

(show top 50)    (show all 62)
idTitleAuthorsYear
1
Low level of tracheal cellular fibronectin in extremely premature infants with funisitis: Relationship with respiratory distress 1 month after birth. (24155097)
2013
2
Postnatal changes of cytokines in premature infants with or without funisitis. (24246233)
2013
3
The association between histological chorioamnionitis, funisitis and neonatal outcome in women with preterm prelabor rupture of membranes. (23489073)
2013
4
Pulsation of the fetal splenic vein--a potential ultrasound marker of histological chorioamnionitis and funisitis in women with preterm prelabor rupture of membranes. (22574855)
2012
5
A prediction model of histological chorioamnionitis and funisitis in preterm prelabor rupture of membranes: analyses of multiple proteins in the amniotic fluid. (22372866)
2012
6
Relationship between maternal serum C-reactive protein, funisitis and early-onset neonatal sepsis. (22690100)
2012
7
Maternal C-reactive protein at hospital admission is a simple predictor of funisitis in preterm premature rupture of membranes. (22710247)
2012
8
Maternal serum interleukin-6 levels predict impending funisitis in preterm premature rupture of membranes after completion of antibiotics. (22046977)
2012
9
Bleeding per vaginam is associated with funisitis in women with preterm prelabour rupture of the fetal membranes. (21392243)
2011
10
Correlation between placental histopathology and fetal/neonatal outcome: chorioamnionitis and funisitis are associated to intraventricular haemorrage and retinopathy of prematurity in preterm newborns. (20528214)
2011
11
Neutrophil elastase and interleukin-6 in amniotic fluid as indicators of chorioamnionitis and funisitis. (21645958)
2011
12
Prolonged fetal bradycardia as the presenting clinical sign in congenital syphilis complicated by necrotizing funisitis: a case report. (21766037)
2011
13
The frequency and risk factors of funisitis and histologic chorioamnionitis in pregnant women at term who delivered after the spontaneous onset of labor. (20698737)
2011
14
Funisitis and chorionic vasculitis: relation to chorioamnionitis, timing and scoring. (22059462)
2011
15
The presence of funisitis is associated with a decreased risk for the development of neonatal respiratory distress syndrome. (21216461)
2011
16
Impact of histological chorioamnionitis, funisitis and clinical chorioamnionitis on neurodevelopmental outcome of preterm infants. (21354722)
2011
17
Funisitis is associated with increased interleukin-10 gene expression in cord blood mononuclear cells in preterm infants a8o32 weeks of gestation. (21183270)
2011
18
Airway concentrations of angiopoietin-1 and endostatin in ventilated extremely premature infants are decreased after funisitis and unbalanced with bronchopulmonary dysplasia/death. (19127216)
2009
19
Dermatophilus congolensis-associated placentitis, funisitis and abortion in a horse. (18405341)
2008
20
Increased numbers of macrophages in tracheal aspirates in premature infants with funisitis. (18353056)
2008
21
Induction of necrotizing funisitis by fetal administration of intravenous granulocyte-colony stimulating factor and intra-amniotic endotoxin in premature fetal sheep. (17957156)
2007
22
Umbilical cord hematoma: association with chorioamnionitis and funisitis. (17611840)
2007
23
Proteomic biomarkers of intra-amniotic inflammation: relationship with funisitis and early-onset sepsis in the premature neonate. (17314690)
2007
24
The value of cord blood interleukin-6 levels for predicting chorioamnionitis, funisitis and neonatal infection in term premature rupture of membranes. (16459014)
2006
25
Chorioamnionitis with or without funisitis increases the risk of hypotension in very low birthweight infants on the first postnatal day but not later. (16624881)
2006
26
Funisitis in term pregnancy is associated with microbial invasion of the amniotic cavity and intra-amniotic inflammation. (17127492)
2006
27
Funisitis associated with leptospiral abortion in an equine placenta. (16145212)
2005
28
Funisitis and raised interleukin 6 concentrations in gastric aspirates at birth. (16036897)
2005
29
Are histopathologic chorioamnionitis and funisitis associated with metabolic acidosis in the preterm fetus? (15592284)
2004
30
Chorioamnionitis/funisitis and the development of bronchopulmonary dysplasia. (15228562)
2004
31
C-reactive protein in umbilical cord blood: a simple and widely available clinical method to assess the risk of amniotic fluid infection and funisitis. (14629087)
2003
32
Funisitis and chorionic vasculitis: the histological counterpart of the fetal inflammatory response syndrome. (12380603)
2002
33
Re-evaluation of chorioamnionitis and funisitis with a special reference to subacute chorioamnionitis. (11957143)
2002
34
Meconium-stained amniotic fluid and neonatal morbidity in near-term and term deliveries with acute histologic chorioamnionitis and/or funisitis. (11774015)
2001
35
Acute funisitis of preterm but not term placentas is associated with severe fetal inflammatory response. (11431717)
2001
36
Testing umbilical cords for funisitis due to Treponema pallidum infection, Bolivia. (10998379)
2000
37
The role of low molecular weight hyaluronic acid contained in Wharton's jelly in necrotizing funisitis. (10203142)
1999
38
Necrotizing funisitis with intrapartum umbilical cord rupture. (10685250)
1999
39
Candida funisitis: A clinicopathologic study of 32 cases. (9507035)
1998
40
Necrotizing funisitis: clinical significance and association with chronic lung disease in premature infants. (9423742)
1997
41
Necrotizing funisitis associated with Actinomyces meyeri infection: a case report. (7855012)
1994
42
Necrotizing funisitis and herpes simplex infection of placental and decidual tissues: study of four cases. (8026831)
1994
43
Necrotizing funisitis: a study of 45 cases. (1427754)
1992
44
The pathophysiology of acute syphilitic funisitis. (12797042)
1991
45
Candida albicans placentitis and funisitis: early diagnosis of congenital candidemia by histopathologic examination of umbilical cord vessels. (2235191)
1990
46
Congenital syphilis and necrotizing funisitis. (2754789)
1989
47
Congenital syphilis and necrotizing funisitis. (2918676)
1989
48
Chorioamnionitis and funisitis due to Corynebacterium kutscheri. (518110)
1979
49
Chronic viral funisitis. (925832)
1977
50
Subacute necrotizing funisitis. A variant of cord inflammation with a high rate of perinatal infection. (4418774)
1974

Genetic Variations for Funisitis

Expression for genes affiliated with Funisitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Funisitis

Search GEO for disease gene expression data for Funisitis.

Pathways for genes affiliated with Funisitis

Sources:
52QIAGEN, 30KEGG, 38NCBI BioSystems Database, 12EMD Millipore, 53R&D Systems, 54Reactome
See all sources

Pathways related to Funisitis according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1ANGPT1
2
Hide members
10.1ANGPT1
3
Hide members
10.1ANGPT1
410.1ANGPT1
510.1IL8
6
Hide members
9.8ANGPT1, COL18A1
79.7IL6, IL8
89.4IL6, IL1B
99.4IL1B, IL6
10
Hide members
9.1IL6, IL1B, IL8
11
Hide members
9.1IL8, IL1B, IL6
129.1IL8, IL1B, IL6
13
Hide members
9.1IL8, IL1B, IL6
149.1IL8, IL1B, IL6
15
Immune response Bacterial infections in normal airways
Hide members
9.1IL8, IL1B, IL6
169.1IL8, IL1B, IL6
179.0IL6, IL1B, IL10
189.0IL10, IL1B, IL6
199.0IL10, IL1B, IL6
20
Hide members
9.0IL10, IL1B, IL6
219.0IL6, IL1B, IL10
22
Hide members
9.0IL6, IL1B, IL10
238.9IL6, IL1B, CRP
24
Development PDGF signaling via STATs and NF-kB
Hide members
8.6ANGPT1, IL10, IL1B, IL6
258.6IL10, IL8, IL1B, IL6
26
Hide members
8.6IL6, IL1B, IL8, IL10
278.6IL10, IL8, IL1B, IL6
288.6IL6, IL1B, IL8, IL10
298.6IL10, IL8, IL1B, IL6
30
Hide members
8.3ANGPT1, IL10, IL8, IL1B, IL6

Compounds for genes affiliated with Funisitis

Sources:
45Novoseek, 29IUPHAR, 2BitterDB, 60Tocris Bioscience, 11DrugBank, 50PharmGKB, 24HMDB
See all sources

Compounds related to Funisitis according to GeneCards/GeneDecks:

(show top 50)    (show all 105)
idCompoundScoreTop Affiliating Genes
1gm-csf45 2911.4IL10
2endotoxin4510.4S100A8
3hydrocortisone45 2 60 1113.2IL8
4cyclosporin a45 29 6011.9ANGPT1, MMP8, SERPINH1
5ivig459.6S100A12, CRP
6mcp 1459.5IL10, IL8, IL6
7cdp571459.5CRP, IL10, IL6
8echinacea459.4IL1B, IL8, IL10
9taurine chloramine459.4IL8, IL1B, IL6
10azithromycin45 1110.4IL8, IL10, CRP
11hbd2459.4IL8, IL1B, IL6
12turpentine459.4IL6, IL1B, CRP
13toxin-1459.3IL10, IL8, IL1B
14pamidronate45 50 1111.3CRP, IL10, IL6
15monosodium urate459.3IL1B, IL8, S100A8
16bucillamine459.3CRP, IL1B, IL6
17imiquimod45 29 60 1112.3IL10, IL8, IL6
18adalimumab45 50 1111.3CRP, IL10, IL6
19anakinra45 1110.3CRP, IL1B, IL6
20rantes459.3IL6, IL1B, S100A8
21olopatadine45 1110.2S100A12, IL8, IL6
225 aminosalicylic acid459.2IL10, IL8, IL1B
23clodronate45 50 1111.1IL10, IL1B, IL6, MMP8
24flagellin45 2910.1S100A8, IL8, IL1B
258-isoprostane459.1IL6, IL8, IL10, CRP
26as 10160 4510.1IL1B, IL10, S100A8
27tpck459.1IL8, IL1B, IL6
28anaphylatoxin459.1IL6, IL1B, IL8
29mip 1alpha459.1IL10, IL8, IL1B, IL6
30il-12459.0IL10, IL8, IL1B, IL6
31polymyxin b459.0IL10, IL8, IL1B, IL6
32groalpha459.0IL6, IL1B, IL8, IL10
33lipoteichoic acid459.0IL10, IL8, IL1B, IL6
34polyinosinic-polycytidylic acid459.0IL6, IL1B, IL8, IL10
35il 10459.0IL6, IL1B, IL8, IL10
36peptidoglycan45 2910.0IL6, IL1B, IL8, IL10
37ccl345 2910.0IL10, IL8, IL1B, IL6
3815-deoxy-delta-12,14-prostaglandin j2459.0IL10, IL8, IL1B, IL6
39infliximab45 50 1110.9CRP, IL10, IL1B, IL6
40okt3458.8IL6, IL10, CRP
41thalidomide45 50 60 1111.8S100A8, IL10, IL1B, IL6
42simvastatin45 50 60 29 11 2413.6CRP, IL10, IL8, IL6
43etanercept45 50 1110.5IL6, IL1B, IL8, IL10, CRP
44neopterin458.5CRP, IL10, IL8, IL1B, IL6
45sb 20358045 609.4CRP, IL10, IL8, IL1B, IL6
46histamine45 29 2410.3S100A8, IL10, IL8, IL1B, IL6
47methotrexate45 50 1110.3S100A8, CRP, IL10, IL1B, IL6
48ly294002458.2CRP, ANGPT1, IL10, IL8, IL1B, IL6
49vegf457.6CRP, ANGPT1, IL10, IL8, IL1B, IL6
50nitric oxide45 11 249.6S100A8, ANGPT1, IL10, IL8, IL1B, IL6

GO Terms for genes affiliated with Funisitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Funisitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055766.3S100A12, S100A8, CRP, ANGPT1, IL8, IL1B
2extracellular spaceGO:0056156.0SERPINH1, COL18A1, S100A8, CRP, ANGPT1, IL10

Biological processes related to Funisitis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1response to molecule of bacterial originGO:0022379.7IL8, IL10
2negative regulation of lipid storageGO:0108889.7IL6, CRP
3positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.1IL10, IL1B, IL6
4defense response to fungusGO:0508329.1S100A8, S100A12
5monocyte chemotaxisGO:0025488.9IL6, S100A12
6negative regulation of cell proliferationGO:0082858.8COL18A1, IL8, IL1B, IL6
7defense response to bacteriumGO:0427428.6IL10, S100A8, S100A12
8neutrophil chemotaxisGO:0305938.3S100A12, S100A8, IL8, IL1B
9positive regulation of NF-kappaB transcription factor activityGO:0510928.3IL6, IL1B, S100A8, S100A12
10inflammatory responseGO:0069547.0IL6, IL1B, IL8, IL10, CRP, S100A8

Molecular functions related to Funisitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.0IL6, IL1B, IL10
2RAGE receptor bindingGO:0507868.8S100A8, S100A12

Products for genes affiliated with Funisitis

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  • Lysates
  • Antibodies

Sources for Funisitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet