Funisitis malady

Wikipedia: Funisitis is inflammation of the connective tissue of the umbilical cord.⁴⁴ more...

MalaCards: Funisitis, also known as funisitis (disorder), is related to chorioamnionitis and sepsis. An important gene associated with Funisitis is S100A12 (S100 calcium binding protein A12), and among its related pathways are NFAT Signaling and Lymphocyte Interactions and RAR-Gamma-RXR-Alpha Degradation. The compounds histamine and ivig have been mentioned in the context of this disorder. Affiliated tissues include endothelial, and related mouse phenotype cardiovascular system.

Disease Ontology: A connective tissue disease that is an inflammation of the connective tissue of the umbilical cord.⁶

funisitis 6 funisitis (disorder) 43

Diseases related to funisitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 497)

id	Related Disease	Score	Top Affiliating Genes
1	chorioamnionitis	26.2	S100A12, IL10, IL1B, IL6, IL8, CRP
2	sepsis	25.5	S100A8, IL10, IL1B, IL6, IL8, ANGPT1
3	bronchopulmonary dysplasia	24.9	IL10, IL1B, IL6, IL8, ANGPT1, COL18A1
4	vasculitis	24.9	S100A12, IL10, IL1B, IL6, IL8, CRP
5	spondylarthropathy	13.2	S100A8, CRP
6	slow-channel congenital myasthenic syndrome	13.1	IL8, CRP
7	gastric cardia adenocarcinoma	13.0	S100A8, IL8
8	gastritis	13.0	S100A8, IL8
9	stenotrophomonas maltophilia	13.0	IL10, IL8
10	glycogen storage disease type ia	13.0	IL8, CRP
11	alcoholic hepatitis	13.0	IL10, IL8
12	felty's syndrome	13.0	IL10, IL8
13	cardiac sarcoidosis	13.0	S100A8, IL1B
14	x-linked sideroblastic anemia	12.9	IL1B, CRP
15	chronic infantile neurological cutaneous articular syndrome	12.9	IL1B, CRP
16	gallbladder disease	12.9	IL10, CRP
17	malignant histiocytosis	12.9	IL1B, CRP
18	onchocerciasis	12.9	S100A12, S100A8, IL10
19	proctitis	12.9	IL8, CRP
20	periodic fever	12.9	IL1B, CRP
21	aortic atherosclerosis	12.8	IL10, CRP
22	ethmoid sinusitis	12.8	IL1B, IL8
23	blau syndrome	12.8	IL10, IL1B
24	opisthorchiasis	12.8	IL1B, IL8
25	paratyphoid fever	12.8	IL1B, CRP
26	microscopic polyangiitis	12.8	IL10, CRP
27	bronchitis	12.8	S100A8, IL8
28	hepatopulmonary syndrome	12.8	ANGPT1, CRP, COL18A1
29	psoriatic arthritis	12.8	IL1B, CRP
30	cold agglutinin disease	12.8	IL6, CRP
31	adult-onset still's disease	12.8	IL6, CRP
32	viral meningitis	12.8	IL6, CRP
33	alexithymia	12.7	IL6, CRP
34	viral pneumonia	12.7	IL6, CRP
35	septic arthritis	12.7	IL1B, CRP
36	spermatocele	12.7	IL6, IL8
37	mycobacterium avium complex disease	12.7	IL10, IL6
38	common wart	12.7	IL6, IL8
39	carotid intimal medial thickness	12.7	IL6, CRP
40	intussusception	12.7	IL6, CRP
41	metabolic syndrome x	12.7	IL6, CRP
42	cortisol resistance	12.7	IL10, IL6
43	capillary leak syndrome	12.7	IL6, IL8
44	food allergy	12.6	S100A8, IL10, IL8
45	intraocular lymphoma	12.6	IL10, IL6
46	conjunctivochalasis	12.6	IL6, IL8
47	cerebral malaria	12.6	IL10, IL1B
48	systolic heart failure	12.6	IL6, CRP
49	post-transplant lymphoproliferative disease	12.6	IL10, IL6
50	zollinger-ellison syndrome	12.6	IL6, IL8

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to funisitis:

²²

MGI Mouse Phenotypes related to funisitis:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system phenotype	MP:0005385	7.4	IL10, IL1B, IL6, ANGPT1, CRP, COL18A1

Articles related to funisitis:

id	Title	Authors	Year	Affiliating Genes
1	Funisitis is associated with increased interleukin-10 gene expression in cord blood mononuclear cells in preterm infants a8o32 weeks o f gestation. (21183270)	Wirbelauer J.... Speer C.P.	2011	IL10
2	Airway concentrations of angiopoietin-1 and endostatin in ventilated extremely premature infants are decreased after funisitis and unbalanced with bronchopulmonary dysplasia/death. (19127216)	Thomas W.... Speer C.P.	2009	ANGPT1, COL18A1
3	Proteomic biomarkers of intra-amniotic inflammation: relationship with funisitis and early-onset sepsis in the premature neonate. (17314690)	Buhimschi C.S.... Bhandari V.	2007	S100A8, S100A12
4	The value of cord blood interleukin-6 levels for predicting chorioamnionitis, funisitis and neonatal infection in term premature rupture of membranes. (16459014)	Tasci Y.... Han U.	2006	IL6
5	Activation of umbilical cord endothelial cells and fetal inflammatory response in preterm infants with chorioamnionitis and funisitis. (15611353)	D'Alquen D.... Speer C.P.	2005	IL6, IL1B, IL8
6	C-reactive protein in umbilical cord blood: a simple and widely available clinical method to assess the risk of amniotic fluid infection and funisitis. (14629087)	Yoon B.H.... Jun J.K.	2003	IL6, CRP
7	Funisitis and chorionic vasculitis: the histological counterpart of the fetal inflammatory response syndrome. (12380603)	Pacora P.... Romero R.	2002	IL6
8	The relationship among inflammatory lesions of the umbilical cord (funisitis), umbilical cord plasma interleukin 6 concentration, amniotic fluid infection, and neonatal sepsis. (11084553)	Yoon B.H.... Jun J.K.	2000	IL6
9	The role of low molecular weight hyaluronic acid cont ained in Wharton's jelly in necrotizing funisitis. (10203142)	Kanayama N.... Terao T.	1999	IL8

Genes related to funisitis according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	S100A12	S100 calcium binding protein A12	11.0	Publications
2	COL18A1	collagen, type XVIII, alpha 1	11.0	Publications
3	S100A8	S100 calcium binding protein A8	11.0	Publications
4	ANGPT1	angiopoietin 1	11.0	Publications
5	IL10	interleukin 10	11.0	Publications
6	CRP	C-reactive protein, pentraxin-related	11.0	Publications
7	IL8	interleukin 8	11.0	Publications
8	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
9	IL1B	interleukin 1, beta	11.0	Publications

Pathways related to funisitis according to GeneDecks:

(show all 46)

id	Pathway	Score	Top Affiliating Genes
1	NFAT Signaling and Lymphocyte Interactions36	10.5	ANGPT1
2	RAR-Gamma-RXR-Alpha Degradation36	10.5	ANGPT1
3	Immune response_Bacterial infections in normal airways41	10.2	IL1B
4	Regulation of eIF4 and p70S6K36	10.1	IL6
5	PGC1Alpha Pathway36	9.8	IL8, IL1B
6	Molecular Mechanisms of Cancer36	9.3	COL18A1, ANGPT1, IL6
7	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.2	IL1B, IL6
8	Immune response_MIF-mediated glucocorticoid regulation41	9.0	IL6, IL8
9	IL-10 Pathway36	9.0	IL10, IL1B, IL6
10	African trypanosomiasis20	9.0	IL6, IL1B, IL10
11	Immune response_MIF in innate immunity response41	8.8	IL8, IL6, IL1B
12	Immune response MIF in innate immunity response10	8.8	IL8, IL6, IL1B
13	Immune response IL-1 signaling pathway10	8.7	IL8, IL6, IL1B
14	Immune response MIF-mediated glucocorticoid regulation10	8.7	IL6, IL8
15	Immune response_IL-1 signaling pathway41	8.7	IL1B, IL6, IL8
16	NOD-like receptor signaling pathway20	8.7	IL1B, IL6, IL8
17	Selected targets of GCR-alpha10	8.7	IL8, IL6, IL1B
18	Toll-like receptor signaling pathway20	8.6	IL8, IL6, IL1B
19	Tuberculosis20	8.6	IL10, IL1B, IL6
20	Influenza A20	8.5	IL8, IL6, IL1B
21	Tec Kinases Signaling36	8.5	IL10, IL6, IL8, ANGPT1
22	Cytokine Network36	8.5	IL8, IL6, IL1B, IL10
23	Rheumatoid arthritis20	8.5	IL1B, IL6, IL8, ANGPT1
24	Malaria20	8.5	IL8, IL6, IL1B, IL10
25	Pertussis20	8.4	IL10, IL1B, IL6, IL8
26	Chagas disease (American trypanosomiasis)20	8.4	IL8, IL6, IL1B, IL10
27	Amoebiasis20	8.4	IL10, IL1B, IL6, IL8
28	Cytokine-cytokine receptor interaction20	8.2	IL10, IL1B, IL6, IL8
29	MIF Mediated Glucocorticoid Regulation36	8.1	IL10, IL1B, IL6, IL8, ANGPT1
30	MIF Regulation of Innate Immune Cells36	8.1	ANGPT1, IL8, IL6, IL1B, IL10
31	all-trans-Retinoic Acid Signaling in Brain36	8.1	ANGPT1, IL8, IL6, IL1B, IL10
32	PEDF Induced Signaling36	8.1	IL10, IL1B, IL6, IL8, ANGPT1
33	SOCS Pathway36	8.1	ANGPT1, IL8, IL6, IL1B, IL10
34	IL-6 Pathway36	8.1	IL10, IL1B, IL6, IL8, ANGPT1
35	Glucocorticoid Receptor Signaling36	8.0	IL10, IL1B, IL6, IL8, ANGPT1
36	STAT3 Pathway36	8.0	ANGPT1, IL8, IL6, IL1B, IL10
37	Endothelin-1 Signaling Pathway36	8.0	ANGPT1, IL8, IL6, IL1B, IL10
38	TGF-Beta Pathway36	8.0	ANGPT1, IL8, IL6, IL1B, IL10
39	PAK Pathway36	8.0	ANGPT1, IL8, IL6, IL1B, IL10
40	MAPK Family Pathway36	8.0	IL10, IL1B, IL6, IL8, ANGPT1
41	JAK-STAT Pathway36	8.0	ANGPT1, IL8, IL6, IL1B, IL10
42	Antioxidant Action of Vitamin-C36	8.0	ANGPT1, IL8, IL6, IL1B, IL10
43	p38 Signaling36	8.0	ANGPT1, IL8, IL6, IL1B, IL10
44	Akt Signaling36	7.9	ANGPT1, IL8, IL6, IL1B, IL10
45	Rho Family GTPases36	7.7	COL18A1, ANGPT1, IL8, IL6, IL1B, IL10
46	ERK Signaling36	7.7	COL18A1, ANGPT1, IL8, IL6, IL1B, IL10

Compounds related to funisitis according to GeneDecks:

(show top 50)    (show all 98)

id	Compound	Score	Top Affiliating Genes
1	histamine32 18	11.4	S100A8
2	ivig32	10.1	S100A12, CRP
3	endotoxin32	10.0	CRP, S100A8
4	rantes32	10.0	IL6
5	groalpha32	9.9	IL10, IL1B
6	sb 20358032 42	10.5	CRP, IL6
7	monosodium urate32	9.3	IL8, S100A8, IL1B
8	echinacea32	9.3	IL1B, IL8, IL10
9	vegf32	9.2	IL1B, CRP, ANGPT1
10	toxin-132	9.2	IL8, IL1B, IL10
11	azithromycin32 9 9	11.2	CRP, IL10, IL8
12	cdp57132	9.1	IL10, IL6, CRP
13	flagellin32	9.1	IL8, S100A8, IL1B
14	olopatadine32 9 9	11.0	S100A12, IL6, IL8
15	turpentine32	9.0	IL1B, CRP, IL6
16	bucillamine32	9.0	IL1B, IL6, CRP
17	anakinra32 9 9	11.0	CRP, IL1B, IL6
18	tenidap42 32	10.0	IL6, IL1B, CRP
19	pamidronate32 9 9	10.9	IL6, IL10, CRP
20	5 aminosalicylic acid32	8.9	IL8, IL1B, IL10
21	clodronate32 9 9	10.9	IL10, IL6, IL1B
22	mcp 132	8.9	IL6, IL10, IL8
23	adalimumab32 9 9	10.9	CRP, IL6, IL10
24	ulinastatin32	8.9	IL10, IL6, IL8
25	taurine chloramine32	8.9	IL8, IL6, IL1B
26	hbd232	8.8	IL8, IL6, IL1B
27	okt332	8.7	IL6, CRP, IL10
28	imiquimod32 42 9 9	11.6	IL6, IL8, IL10
29	infliximab32 9 9	10.6	IL6, IL1B, IL10, CRP
30	gabexate mesilate32	8.5	IL6, CRP, IL8, IL10
31	mip 1alpha32	8.5	IL6, IL10, IL1B, IL8
32	il-1232	8.5	IL1B, IL6, IL8, IL10
33	polymyxin b32	8.5	IL6, IL10, IL1B, IL8
34	gm-csf32	8.5	IL6, IL1B, IL10, IL8
35	lipoteichoic acid32	8.5	IL6, IL1B, IL10, IL8
36	8-isoprostane32	8.5	CRP, IL8, IL6, IL10
37	polyinosinic-polycytidylic acid32	8.5	IL8, IL10, IL1B, IL6
38	il 1032	8.5	IL6, IL8, IL1B, IL10
39	peptidoglycan32	8.4	IL10, IL1B, IL6, IL8
40	ccl332	8.4	IL1B, IL10, IL8, IL6
41	pentoxifylline32 9 9	10.4	IL10, IL6, IL8, IL1B
42	15-deoxy-delta-12,14-prostaglandin j232	8.4	IL1B, IL6, IL10, IL8
43	tpck32	8.4	IL8, IL6, IL1B
44	hydrocortisone32 9 9	10.2	IL1B, IL6, IL8, IL10
45	methotrexate32 34 42 9 9	12.2	CRP, S100A8, IL10, IL1B, IL6
46	etanercept32 9 9	10.0	IL1B, IL10, IL6, IL8, CRP
47	neopterin32	8.0	IL10, IL1B, IL6, CRP, IL8
48	simvastatin32 34 42 9 18 9	12.8	IL6, CRP, IL8, IL10
49	ly29400232	7.6	IL1B, IL6, IL8, ANGPT1, CRP, IL10
50	nitric oxide32 9 18 9	10.4	ANGPT1, IL6, S100A8, IL1B, IL10, IL8

Cellular components related to funisitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:005576	6.9	CRP, ANGPT1, IL8, IL6, IL1B, S100A12
2	extracellular space	GO:005615	6.1	S100A8, COL18A1, CRP, ANGPT1, IL8, IL6

Biological processes related to funisitis according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	response to molecule of bacterial origin	GO:002237	9.3	IL8, IL10
2	negative regulation of lipid storage	GO:010888	9.3	IL6, CRP
3	anti-apoptosis	GO:006916	9.1	IL10, IL1B, ANGPT1
4	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	8.8	IL10, IL1B, IL6
5	response to glucocorticoid stimulus	GO:051384	8.7	IL6, IL1B, IL10
6	response to hypoxia	GO:001666	8.7	IL1B, ANGPT1, CRP
7	negative regulation of cell proliferation	GO:008285	8.2	IL1B, IL6, IL8, COL18A1
8	inflammatory response	GO:006954	7.0	S100A12, CRP, IL8, IL6, IL1B, IL10

Molecular functions related to funisitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	growth factor activity	GO:008083	8.7	IL10, IL1B, IL6
2	cytokine activity	GO:005125	8.4	IL10, IL1B, IL6