Aliases & Classifications for Funisitis

MalaCards integrated aliases for Funisitis:

Name: Funisitis 12 14 69

External Ids:

Disease Ontology 12 DOID:0050698
UMLS 69 C1275592

Summaries for Funisitis

Disease Ontology : 12 A connective tissue disease that is an inflammation of the connective tissue of the umbilical cord.

MalaCards based summary : Funisitis is related to chorioamnionitis and preterm premature rupture of the membranes. An important gene associated with Funisitis is IL6 (Interleukin 6), and among its related pathways/superpathways are PEDF Induced Signaling and TGF-Beta Pathway. The drugs Acetaminophen and Acetylcysteine have been mentioned in the context of this disorder. Affiliated tissues include placenta, testes and neutrophil, and related phenotype is cardiovascular system.

Wikipedia : 72 Funisitis is inflammation of the connective tissue of the umbilical cord, which may cause... more...

Related Diseases for Funisitis

Diseases related to Funisitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 240)
# Related Disease Score Top Affiliating Genes
1 chorioamnionitis 30.8 CXCL8 IL1B IL6
2 preterm premature rupture of the membranes 30.2 CXCL8 IL6 SERPINH1
3 lung disease 29.6 CXCL8 IL10 IL1B
4 streptococcal toxic-shock syndrome 10.4 CXCL8 IL6
5 denture stomatitis 10.4 CXCL8 IL6
6 papillary conjunctivitis 10.4 CXCL8 IL6
7 acute monoblastic leukemia 10.4 CXCL8 IL6
8 capillary leak syndrome 10.4 CXCL8 IL6
9 meconium aspiration syndrome 10.4 CXCL8 IL6
10 louse-borne relapsing fever 10.4 CXCL8 IL6
11 necrotizing fasciitis 10.4 CXCL8 IL6
12 tungiasis 10.4 CXCL8 IL10
13 scabies 10.4 CXCL8 IL10
14 pouchitis 10.4 CXCL8 IL10
15 cowpox 10.4 CXCL8 IL6
16 vulvovaginitis 10.4 CXCL8 IL10
17 necatoriasis 10.4 CXCL8 IL10
18 trichuriasis 10.4 CXCL8 IL10
19 bacteriuria 10.4 CXCL8 IL6
20 clonorchiasis 10.4 CXCL8 IL10
21 acute cystitis 10.4 CXCL8 IL6
22 retinitis pigmentosa 44 10.4 CXCL8 IL10
23 eye lymphoma 10.3 IL10 IL6
24 immune suppression 10.3 IL10 IL6
25 mycetoma 10.3 CXCL8 IL10
26 fasciitis 10.3 CXCL8 IL6
27 primary peritoneal carcinoma 10.3 CXCL8 IL10
28 viral meningitis 10.3 CXCL8 IL6
29 peptic esophagitis 10.3 CXCL8 IL1B
30 listeriosis 10.3 IL10 IL6
31 multicentric castleman disease 10.3 IL10 IL6
32 haemophilus influenzae 10.3 CXCL8 IL1B
33 opisthorchiasis 10.3 CXCL8 IL1B
34 hand, foot and mouth disease 10.3 IL10 IL6
35 intermediate uveitis 10.3 IL10 IL6
36 post-transplant lymphoproliferative disease 10.3 IL10 IL6
37 crohn's colitis 10.3 CXCL8 IL1B
38 radiculopathy 10.3 IL10 IL6
39 hemorrhagic fever 10.3 IL10 IL6
40 dental pulp disease 10.3 CXCL8 IL1B
41 periodontitis, chronic 10.3 IL1B IL6
42 traumatic brain injury 10.3 IL10 IL6
43 cervical incompetence 10.3 IL6 SERPINH1
44 hematopoietic stem cell transplantation 10.3 IL10 IL6
45 uremic pruritus 10.3 IL1B IL6
46 euthyroid sick syndrome 10.3 IL1B IL6
47 laryngitis 10.3 IL1B IL6
48 ascaris lumbricoides infection 10.3 IL1B IL6
49 acute vascular insufficiency of intestine 10.3 IL1B IL6
50 poems syndrome 10.3 IL1B IL6

Graphical network of the top 20 diseases related to Funisitis:



Diseases related to Funisitis

Symptoms & Phenotypes for Funisitis

MGI Mouse Phenotypes related to Funisitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.1 ANGPT1 IL10 IL1B IL6 SELE SERPINH1

Drugs & Therapeutics for Funisitis

Drugs for Funisitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 1, Phase 2 103-90-2 1983
2
Acetylcysteine Approved, Investigational Phase 1, Phase 2 616-91-1 12035
3 Antidotes Phase 1, Phase 2
4 Anti-Infective Agents Phase 1, Phase 2
5 Antioxidants Phase 1, Phase 2
6 Antiviral Agents Phase 1, Phase 2
7 Expectorants Phase 1, Phase 2
8 N-monoacetylcystine Phase 1, Phase 2
9 Pharmaceutical Solutions Phase 1, Phase 2
10 Protective Agents Phase 1, Phase 2,Early Phase 1
11 Respiratory System Agents Phase 1, Phase 2
12
Oxytocin Approved, Vet_approved 50-56-6 53477758 439302
13
Methylprednisolone Approved, Vet_approved Early Phase 1 83-43-2 6741
14
Prednisolone Approved, Vet_approved Early Phase 1 50-24-8 5755
15 Oxytocics
16 Antiemetics Early Phase 1
17 Anti-Inflammatory Agents Early Phase 1
18 Antineoplastic Agents, Hormonal Early Phase 1
19 Autonomic Agents Early Phase 1
20 Gastrointestinal Agents Early Phase 1
21 glucocorticoids Early Phase 1
22 Hormone Antagonists Early Phase 1
23 Hormones Early Phase 1
24 Hormones, Hormone Substitutes, and Hormone Antagonists Early Phase 1
25 Methylprednisolone acetate Early Phase 1
26 Methylprednisolone Hemisuccinate Early Phase 1
27 Neuroprotective Agents Early Phase 1
28 Peripheral Nervous System Agents Early Phase 1
29 Prednisolone acetate Early Phase 1
30 Prednisolone hemisuccinate Early Phase 1
31 Prednisolone phosphate Early Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 N-acetylcysteine in Intra-amniotic Infection/Inflammation Completed NCT00397735 Phase 1, Phase 2 N-acetylcysteine or placebo
2 FOLCROM Trial: Foley Catheter in Rupture of Membranes Completed NCT01973036 Oxytocin
3 Microbiome And Multi'Omics In Preterm Birth: The Bacteria And Birth Study Recruiting NCT02392650
4 Multimodal Monitoring of Fetal Risk of Inflammation in Preterm Premature Rupture of Membranes Recruiting NCT02702297
5 Maternal Epidural Steroids and Hyperthemia Terminated NCT02212210 Early Phase 1 Methylprednisolone;Normal saline

Search NIH Clinical Center for Funisitis

Genetic Tests for Funisitis

Anatomical Context for Funisitis

MalaCards organs/tissues related to Funisitis:

38
Placenta, Testes, Neutrophil, Endothelial, Lung

Publications for Funisitis

Articles related to Funisitis:

(show top 50) (show all 78)
# Title Authors Year
1
Prenatal diagnosis of funisitis: two case reports. ( 29396737 )
2018
2
Histologic Funisitis and Likelihood of Intrauterine Inflammation or Infection: A Case-Control Study. ( 29365327 )
2018
3
Histological changes in the umbilical artery following severe chorioamnionitis and funisitis may be indicative of early atherosclerosis. ( 28161060 )
2017
4
Preterm labor and preterm premature rupture of membranes have a different pattern in the involved compartments of acute histologoic chorioamnionitis and/or funisitis: Patho-physiologic implication related to different clinical manifestations. ( 27090052 )
2016
5
Prognostic value of funisitis and/or chorionic vasculitis compared to histologic chorioamnionitis in full-term infants. ( 27023390 )
2016
6
Histologic Chorioamnionitis and Funisitis After Laser Surgery for Twin-Twin Transfusion Syndrome. ( 27399997 )
2016
7
Elevated C-reactive protein levels in histological chorioamnionitis at term: impact of funisitis on term neonates. ( 27450900 )
2016
8
Funisitis is associated with adverse neonatal outcome in low-risk unselected deliveries at or near term. ( 26868144 )
2016
9
Pro-inflammatory immune responses in leukocytes of premature infants exposed to maternal chorioamnionitis or funisitis. ( 27814345 )
2016
10
Funisitis is more common in cervical insufficiency than in preterm labor and preterm premature rupture of membranes. ( 26812854 )
2016
11
A new anti-microbial combination prolongs the latency period, reduces acute histologic chorioamnionitis as well as funisitis, and improves neonatal outcomes in preterm PROM. ( 26373262 )
2015
12
Acute chorioamnionitis and funisitis: definition, pathologic features, and clinical significance. ( 26428501 )
2015
13
Differential amniotic fluid cytokine profile in women with chorioamnionitis with and without funisitis. ( 26372455 )
2015
14
Clinical chorioamnionitis at term VI: acute chorioamnionitis and funisitis according to the presence or absence of microorganisms and inflammation in the amniotic cavity. ( 26352071 )
2015
15
Is there a stepwise increase in neonatal morbidities according to histological stage (or grade) of acute chorioamnionitis and funisitis?: effect of gestational age at delivery. ( 25153209 )
2014
16
Acute funisitis is associated with distinct changes in fetal hematologic profile. ( 24863633 )
2014
17
Low level of tracheal cellular fibronectin in extremely premature infants with funisitis: Relationship with respiratory distress 1 month after birth. ( 24155097 )
2013
18
A fetal and an intra-amniotic inflammatory response is more severe in preterm labor than in preterm PROM in the context of funisitis: unexpected observation in human gestations. ( 23658737 )
2013
19
The association between histological chorioamnionitis, funisitis and neonatal outcome in women with preterm prelabor rupture of membranes. ( 23489073 )
2013
20
Postnatal changes of cytokines in premature infants with or without funisitis. ( 24246233 )
2013
21
Maternal serum interleukin-6 levels predict impending funisitis in preterm premature rupture of membranes after completion of antibiotics. ( 22046977 )
2012
22
Pulsation of the fetal splenic vein--a potential ultrasound marker of histological chorioamnionitis and funisitis in women with preterm prelabor rupture of membranes. ( 22574855 )
2012
23
Expression of angiogenesis-related factors and inflammatory cytokines in placenta and umbilical vessels in pregnancies with preeclampsia and chorioamnionitis/funisitis. ( 22639995 )
2012
24
A prediction model of histological chorioamnionitis and funisitis in preterm prelabor rupture of membranes: analyses of multiple proteins in the amniotic fluid. ( 22372866 )
2012
25
Relationship between maternal serum C-reactive protein, funisitis and early-onset neonatal sepsis. ( 22690100 )
2012
26
Maternal C-reactive protein at hospital admission is a simple predictor of funisitis in preterm premature rupture of membranes. ( 22710247 )
2012
27
Neutrophil elastase and interleukin-6 in amniotic fluid as indicators of chorioamnionitis and funisitis. ( 21645958 )
2011
28
Impact of histological chorioamnionitis, funisitis and clinical chorioamnionitis on neurodevelopmental outcome of preterm infants. ( 21354722 )
2011
29
Prolonged fetal bradycardia as the presenting clinical sign in congenital syphilis complicated by necrotizing funisitis: a case report. ( 21766037 )
2011
30
Funisitis and chorionic vasculitis: relation to chorioamnionitis, timing and scoring. ( 22059462 )
2011
31
Funisitis is associated with increased interleukin-10 gene expression in cord blood mononuclear cells in preterm infants a8o32 weeks of gestation. ( 21183270 )
2011
32
Correlation between placental histopathology and fetal/neonatal outcome: chorioamnionitis and funisitis are associated to intraventricular haemorrage and retinopathy of prematurity in preterm newborns. ( 20528214 )
2011
33
The presence of funisitis is associated with a decreased risk for the development of neonatal respiratory distress syndrome. ( 21216461 )
2011
34
Bleeding per vaginam is associated with funisitis in women with preterm prelabour rupture of the fetal membranes. ( 21392243 )
2011
35
The frequency and risk factors of funisitis and histologic chorioamnionitis in pregnant women at term who delivered after the spontaneous onset of labor. ( 20698737 )
2011
36
Funisitis and risk for the development of neonatal respiratory distress syndrome. ( 21531459 )
2011
37
Soluble receptor for advanced glycation end products (sRAGE) in tracheobronchial aspirate fluid and cord blood of very low birth weight infants with chorioamnionitis and funisitis. ( 20727688 )
2010
38
Airway concentrations of angiopoietin-1 and endostatin in ventilated extremely premature infants are decreased after funisitis and unbalanced with bronchopulmonary dysplasia/death. ( 19127216 )
2009
39
The antenatal identification of funisitis with a rapid MMP-8 bedside test. ( 19127606 )
2008
40
Dermatophilus congolensis-associated placentitis, funisitis and abortion in a horse. ( 18405341 )
2008
41
Increased numbers of macrophages in tracheal aspirates in premature infants with funisitis. ( 18353056 )
2008
42
Umbilical cord hematoma: association with chorioamnionitis and funisitis. ( 17611840 )
2007
43
Induction of necrotizing funisitis by fetal administration of intravenous granulocyte-colony stimulating factor and intra-amniotic endotoxin in premature fetal sheep. ( 17957156 )
2007
44
Ureaplasma urealyticum and Mycoplasma hominis presence in umbilical cord is associated with pathogenesis of funisitis. ( 18204300 )
2007
45
Proteomic biomarkers of intra-amniotic inflammation: relationship with funisitis and early-onset sepsis in the premature neonate. ( 17314690 )
2007
46
The value of cord blood interleukin-6 levels for predicting chorioamnionitis, funisitis and neonatal infection in term premature rupture of membranes. ( 16459014 )
2006
47
Funisitis in term pregnancy is associated with microbial invasion of the amniotic cavity and intra-amniotic inflammation. ( 17127492 )
2006
48
Chorioamnionitis with or without funisitis increases the risk of hypotension in very low birthweight infants on the first postnatal day but not later. ( 16624881 )
2006
49
Funisitis and raised interleukin 6 concentrations in gastric aspirates at birth. ( 16036897 )
2005
50
Congenital cutaneous candidiasis with funisitis. ( 15781940 )
2005

Variations for Funisitis

Expression for Funisitis

Search GEO for disease gene expression data for Funisitis.

Pathways for Funisitis

Pathways related to Funisitis according to GeneCards Suite gene sharing:

(show all 48)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.43 ANGPT1 CXCL8 IL10 IL1B IL6
2
Show member pathways
13.32 ANGPT1 CXCL8 IL10 IL1B IL6
3
Show member pathways
13.21 ANGPT1 CXCL8 IL10 IL1B IL6
4
Show member pathways
13.16 ANGPT1 CXCL8 IL10 IL1B IL6
5
Show member pathways
13.1 ANGPT1 CXCL8 IL10 IL1B IL6
6
Show member pathways
12.69 CXCL8 IL10 IL1B IL6
7
Show member pathways
12.44 ANGPT1 IL10 IL1B IL6
8
Show member pathways
12.42 IL10 IL1B IL6
9
Show member pathways
12.37 CXCL8 IL10 IL1B IL6
10
Show member pathways
12.27 IL10 IL1B IL6
11
Show member pathways
12.18 CXCL8 IL1B IL6
12
Show member pathways
12.13 CXCL8 IL1B IL6
13 12.1 IL10 IL1B IL6
14
Show member pathways
12.05 CXCL8 IL1B IL6
15 12.04 CXCL8 IL10 IL1B IL6
16
Show member pathways
12.01 CXCL8 IL10 IL1B IL6
17 11.89 CXCL8 IL1B IL6
18 11.84 IL1B IL6 SELE
19 11.84 CXCL8 IL10 IL1B IL6
20 11.82 CXCL8 IL1B IL6
21
Show member pathways
11.81 IL10 IL1B IL6
22 11.75 CXCL8 IL1B IL6 SELE
23 11.72 CXCL8 IL1B IL6
24 11.72 CXCL8 IL10 IL1B IL6
25 11.69 CXCL8 IL6 SELE
26 11.66 ANGPT1 CXCL8 IL1B IL6
27 11.64 IL10 IL1B IL6
28 11.55 CXCL8 IL1B IL6
29 11.55 CXCL8 IL10 IL1B IL6
30 11.48 CXCL8 IL6 SELE
31 11.47 CXCL8 IL1B IL6
32
Show member pathways
11.42 CXCL8 IL1B IL6 SELE
33 11.41 CXCL8 IL6
34 11.38 IL1B IL6
35 11.35 IL1B IL6
36 11.26 IL10 IL1B IL6
37 11.25 CXCL8 IL10 IL1B IL6
38 11.23 IL1B IL6
39 11.21 CXCL8 IL6
40 11.18 IL1B IL6
41 11.17 IL1B IL6
42 11.16 IL10 IL1B IL6
43 10.94 CXCL8 IL6
44 10.85 ANGPT1 CXCL8 IL10 IL1B IL6
45 10.8 IL10 IL1B IL6 SELE
46 10.78 ANGPT1 CXCL8 IL10 IL1B IL6
47 10.72 IL1B IL6
48 10.71 CXCL8 IL10 IL1B IL6 SELE

GO Terms for Funisitis

Cellular components related to Funisitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 ANGPT1 CXCL8 IL10 IL1B IL6 SELE
2 membrane raft GO:0045121 9.13 ANGPT1 SELE SERPINH1

Biological processes related to Funisitis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.73 CXCL8 IL10 IL1B IL6
2 leukocyte migration GO:0050900 9.7 ANGPT1 IL1B SELE
3 response to lipopolysaccharide GO:0032496 9.67 IL10 IL1B SELE
4 regulation of receptor activity GO:0010469 9.62 CXCL8 IL10 IL1B IL6
5 negative regulation of cell proliferation GO:0008285 9.56 CXCL8 IL10 IL1B IL6
6 positive regulation of interleukin-6 production GO:0032755 9.55 IL1B IL6
7 negative regulation of endothelial cell apoptotic process GO:2000352 9.54 ANGPT1 IL10
8 cellular response to lipopolysaccharide GO:0071222 9.54 CXCL8 IL10 IL6
9 positive regulation of receptor internalization GO:0002092 9.51 ANGPT1 SELE
10 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.48 ANGPT1 IL1B
11 response to molecule of bacterial origin GO:0002237 9.46 CXCL8 IL10
12 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.4 IL10 IL1B
13 positive regulation of DNA binding transcription factor activity GO:0051091 9.33 IL10 IL1B IL6
14 inflammatory response GO:0006954 9.02 CXCL8 IL10 IL1B IL6 SELE
15 negative regulation of cytokine secretion involved in immune response GO:0002740 8.96 ANGPT1 IL10

Molecular functions related to Funisitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 CXCL8 IL10 IL1B IL6

Sources for Funisitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
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47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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