MCID: FNS001
MIFTS: 41

Funisitis malady

Summaries for Funisitis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Funisitis is inflammation of the connective tissue of the umbilical cord, which may cause abortion. more...

MalaCards: Funisitis is related to chorioamnionitis and vasculitis. An important gene associated with Funisitis is MMP8 (matrix metallopeptidase 8 (neutrophil collagenase)), and among its related pathways are PEDF Induced Signaling and PAK Pathway. The compounds gm-csf and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include placenta, testes and lung, and related mouse phenotypes are tumorigenesis and cardiovascular system.

Disease Ontology:8 A connective tissue disease that is an inflammation of the connective tissue of the umbilical cord.

Aliases & Classifications for Funisitis

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8Disease Ontology, 10DISEASES, 60UMLS
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Aliases & Descriptions:

funisitis 8 10 60


External Ids:

Disease Ontology8 DOID:0050698

Related Diseases for Funisitis

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17GeneCards, 18GeneDecks
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Diseases related to Funisitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 177)
idRelated DiseaseScoreTop Affiliating Genes
1chorioamnionitis30.8IL8, IL6, IL1B, CRP, S100A12, MMP8
2vasculitis30.1S100A12, CRP
3congenital syphilis10.2
4syphilis10.2
5cerebral palsy10.0MMP8
6esophagitis10.0S100A8
7mixed connective tissue disease10.0S100A8
8dermatomyositis10.0S100A8
9gastroesophageal reflux disease10.0S100A8
10duodenitis10.0S100A8
11lung cancer10.0COL18A1
12periventricular leukomalacia10.0SERPINH1
13bronchopulmonary dysplasia10.0IL8
14sickle cell disease10.0ANGPT1
15sjogren's syndrome10.0S100A8
16ischemia10.0ANGPT1
17ovarian cancer10.0ANGPT1
18bronchiolitis10.0IL8
19arteriosclerosis10.0ANGPT1
20malignant glioma10.0ANGPT1
21endometrial carcinoma10.0ANGPT1
22sarcoidosis10.0IL1B
23interstitial lung disease10.0IL1B
24gingival overgrowth10.0IL1B
25thrombocytopenia10.0IL6
26otitis media10.0IL1B
27cervical incompetence10.0SERPINH1
28pleurisy10.0IL1B
29multiple myeloma10.0IL6
30toxic shock syndrome10.0IL1B
31muckle-wells syndrome10.0IL1B
32degenerative disc disease10.0IL1B
33angiosarcoma10.0ANGPT1
34gout10.0IL1B
35perinatal necrotizing enterocolitis10.0SERPINH1
36uveitis10.0IL10
37rhinitis10.0IL8
38kaposi's sarcoma10.0IL6
39malaria10.0IL10
40myelodysplastic syndromes10.0ANGPT1
41pancreatic cancer10.0IL8
42atopy10.0IL10
43leishmaniasis10.0IL10
44thyroid cancer10.0ANGPT1
45encephalomyelitis10.0IL10
46encephalitis10.0IL1B
47cholesteatoma10.0MMP8, S100A8
48hepatitis c10.0IL10
49adenocarcinoma10.0S100A8, ANGPT1
50gastric ulcer10.0ANGPT1, S100A8

Graphical network of the top 20 diseases related to Funisitis:



Diseases related to funisitis

Clinical Features for Funisitis

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Drugs & Therapeutics for Funisitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Funisitis

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Genetic Tests for Funisitis

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Anatomical Context for Funisitis

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32MalaCards
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MalaCards organs/tissues related to Funisitis:

32
Placenta, Testes, Lung, Endothelial

Animal Models for Funisitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Funisitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.4MMP8, IL6, IL1B, IL10, COL18A1
2MP:00053857.2SERPINH1, COL18A1, CRP, ANGPT1, IL10, IL1B

Publications for Funisitis

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50PubMed
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Articles related to Funisitis:

(show top 50)    (show all 62)
idTitleAuthorsYear
1
A fetal and an intra-amniotic inflammatory response is more severe in preterm labor than in preterm PROM in the context of funisitis: unexpected observation in human gestations. (23658737)
2013
2
Low level of tracheal cellular fibronectin in extremely premature infants with funisitis: Relationship with respiratory distress 1 month after birth. (24155097)
2013
3
Postnatal changes of cytokines in premature infants with or without funisitis. (24246233)
2013
4
The association between histological chorioamnionitis, funisitis and neonatal outcome in women with preterm prelabor rupture of membranes. (23489073)
2013
5
Expression of angiogenesis-related factors and inflammatory cytokines in placenta and umbilical vessels in pregnancies with preeclampsia and chorioamnionitis/funisitis. (22639995)
2012
6
Pulsation of the fetal splenic vein--a potential ultrasound marker of histological chorioamnionitis and funisitis in women with preterm prelabor rupture of membranes. (22574855)
2012
7
A prediction model of histological chorioamnionitis and funisitis in preterm prelabor rupture of membranes: analyses of multiple proteins in the amniotic fluid. (22372866)
2012
8
Relationship between maternal serum C-reactive protein, funisitis and early-onset neonatal sepsis. (22690100)
2012
9
Maternal serum interleukin-6 levels predict impending funisitis in preterm premature rupture of membranes after completion of antibiotics. (22046977)
2012
10
Funisitis and risk for the development of neonatal respiratory distress syndrome. (21531459)
2011
11
Correlation between placental histopathology and fetal/neonatal outcome: chorioamnionitis and funisitis are associated to intraventricular haemorrage and retinopathy of prematurity in preterm newborns. (20528214)
2011
12
Neutrophil elastase and interleukin-6 in amniotic fluid as indicators of chorioamnionitis and funisitis. (21645958)
2011
13
Funisitis and chorionic vasculitis: relation to chorioamnionitis, timing and scoring. (22059462)
2011
14
The presence of funisitis is associated with a decreased risk for the development of neonatal respiratory distress syndrome. (21216461)
2011
15
Impact of histological chorioamnionitis, funisitis and clinical chorioamnionitis on neurodevelopmental outcome of preterm infants. (21354722)
2011
16
Soluble receptor for advanced glycation end products (sRAGE) in tracheobronchial aspirate fluid and cord blood of very low birth weight infants with chorioamnionitis and funisitis. (20727688)
2010
17
Dermatophilus congolensis-associated placentitis, funisitis and abortion in a horse. (18405341)
2008
18
Increased numbers of macrophages in tracheal aspirates in premature infants with funisitis. (18353056)
2008
19
The antenatal identification of funisitis with a rapid MMP-8 bedside test. (19127606)
2008
20
Induction of necrotizing funisitis by fetal administration of intravenous granulocyte-colony stimulating factor and intra-amniotic endotoxin in premature fetal sheep. (17957156)
2007
21
Umbilical cord hematoma: association with chorioamnionitis and funisitis. (17611840)
2007
22
Ureaplasma urealyticum and Mycoplasma hominis presence in umbilical cord is associated with pathogenesis of funisitis. (18204300)
2007
23
The value of cord blood interleukin-6 levels for predicting chorioamnionitis, funisitis and neonatal infection in term premature rupture of membranes. (16459014)
2006
24
Chorioamnionitis with or without funisitis increases the risk of hypotension in very low birthweight infants on the first postnatal day but not later. (16624881)
2006
25
Funisitis in term pregnancy is associated with microbial invasion of the amniotic cavity and intra-amniotic inflammation. (17127492)
2006
26
Congenital cutaneous candidiasis with funisitis. (15781940)
2005
27
Funisitis associated with leptospiral abortion in an equine placenta. (16145212)
2005
28
Activation of umbilical cord endothelial cells and fetal inflammatory response in preterm infants with chorioamnionitis and funisitis. (15611353)
2005
29
Funisitis and raised interleukin 6 concentrations in gastric aspirates at birth. (16036897)
2005
30
Are histopathologic chorioamnionitis and funisitis associated with metabolic acidosis in the preterm fetus? (15592284)
2004
31
Chorioamnionitis/funisitis and the development of bronchopulmonary dysplasia. (15228562)
2004
32
Funisitis and chorionic vasculitis: the histological counterpart of the fetal inflammatory response syndrome. (12380603)
2002
33
Meconium-stained amniotic fluid and neonatal morbidity in near-term and term deliveries with acute histologic chorioamnionitis and/or funisitis. (11774015)
2001
34
The relationship between amniotic fluid matrix metalloproteinase-8 and funisitis. (11717650)
2001
35
Acute funisitis of preterm but not term placentas is associated with severe fetal inflammatory response. (11431717)
2001
36
Testing umbilical cords for funisitis due to Treponema pallidum infection, Bolivia. (10998379)
2000
37
The relationship among inflammatory lesions of the umbilical cord (funisitis), umbilical cord plasma interleukin 6 concentration, amniotic fluid infection, and neonatal sepsis. (11084553)
2000
38
The role of low molecular weight hyaluronic acid contained in Wharton's jelly in necrotizing funisitis. (10203142)
1999
39
Necrotizing funisitis with intrapartum umbilical cord rupture. (10685250)
1999
40
Necrotizing funisitis: clinical significance and association with chronic lung disease in premature infants. (9423742)
1997
41
Necrotizing funisitis associated with Actinomyces meyeri infection: a case report. (7855012)
1994
42
Necrotizing funisitis and herpes simplex infection of placental and decidual tissues: study of four cases. (8026831)
1994
43
Necrotizing funisitis: a study of 45 cases. (1427754)
1992
44
Necrotizing funisitis. (1727589)
1992
45
The pathophysiology of acute syphilitic funisitis. (12797042)
1991
46
Candida albicans placentitis and funisitis: early diagnosis of congenital candidemia by histopathologic examination of umbilical cord vessels. (2235191)
1990
47
Congenital syphilis and necrotizing funisitis. (2754789)
1989
48
Chorioamnionitis and funisitis due to Corynebacterium kutscheri. (518110)
1979
49
Chronic viral funisitis. (925832)
1977
50
Subacute necrotizing funisitis. A variant of cord inflammation with a high rate of perinatal infection. (4418774)
1974

Genetic Variations for Funisitis

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Expression for genes affiliated with Funisitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Funisitis

Search GEO for disease gene expression data for Funisitis.

Pathways for genes affiliated with Funisitis

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51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 52R&D Systems, 53Reactome
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Pathways related to Funisitis according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.1ANGPT1
2
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10.1ANGPT1
3
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10.1ANGPT1
410.1ANGPT1
510.1IL8
6
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9.8ANGPT1, COL18A1
79.7IL6, IL8
89.4IL6, IL1B
99.4IL1B, IL6
10
Hide members
9.1IL6, IL1B, IL8
11
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9.1IL8, IL1B, IL6
129.1IL8, IL1B, IL6
13
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9.1IL8, IL1B, IL6
149.1IL8, IL1B, IL6
15
Immune response Bacterial infections in normal airways
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9.1IL8, IL1B, IL6
169.1IL8, IL1B, IL6
179.0IL6, IL1B, IL10
189.0IL10, IL1B, IL6
199.0IL10, IL1B, IL6
20
Hide members
9.0IL10, IL1B, IL6
219.0IL6, IL1B, IL10
22
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9.0IL6, IL1B, IL10
238.9IL6, IL1B, CRP
24
Development PDGF signaling via STATs and NF-kB
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8.6ANGPT1, IL10, IL1B, IL6
258.6IL10, IL8, IL1B, IL6
26
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8.6IL6, IL1B, IL8, IL10
278.6IL10, IL8, IL1B, IL6
288.6IL6, IL1B, IL8, IL10
298.6IL10, IL8, IL1B, IL6
30
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8.3ANGPT1, IL10, IL8, IL1B, IL6

Compounds for genes affiliated with Funisitis

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44Novoseek, 28IUPHAR, 2BitterDB, 59Tocris Bioscience, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Funisitis according to GeneCards/GeneDecks:

(show top 50)    (show all 105)
idCompoundScoreTop Affiliating Genes
1gm-csf44 2811.4IL10
2endotoxin4410.4S100A8
3hydrocortisone44 2 59 1113.2IL8
4cyclosporin a44 28 5911.9ANGPT1, SERPINH1, MMP8
5ivig449.6CRP, S100A12
6mcp 1449.6IL6, IL8, IL10
7cdp571449.5IL10, CRP, IL6
8echinacea449.4IL1B, IL8, IL10
9taurine chloramine449.4IL6, IL8, IL1B
10azithromycin44 1110.4CRP, IL10, IL8
11hbd2449.4IL1B, IL6, IL8
12turpentine449.4CRP, IL1B, IL6
13pamidronate44 49 1111.3IL10, CRP, IL6
14toxin-1449.3IL1B, IL8, IL10
15monosodium urate449.3S100A8, IL1B, IL8
16bucillamine449.3IL1B, IL6, CRP
17imiquimod44 28 59 1112.3IL6, IL8, IL10
18adalimumab44 49 1111.3IL6, IL10, CRP
19anakinra44 1110.3IL1B, CRP, IL6
20rantes449.3IL6, IL1B, S100A8
21olopatadine44 1110.2IL8, IL6, S100A12
225 aminosalicylic acid449.2IL10, IL8, IL1B
23clodronate44 49 1111.1IL1B, IL6, MMP8, IL10
24flagellin44 2810.1S100A8, IL8, IL1B
258-isoprostane449.1IL6, IL8, CRP, IL10
26as 10159 4410.1IL1B, S100A8, IL10
27tpck449.1IL1B, IL8, IL6
28anaphylatoxin449.1IL1B, IL8, IL6
29mip 1alpha449.1IL10, IL6, IL1B, IL8
30il-12449.0IL6, IL1B, IL8, IL10
31polymyxin b449.0IL8, IL1B, IL10, IL6
32groalpha449.0IL10, IL6, IL1B, IL8
33lipoteichoic acid449.0IL1B, IL10, IL8, IL6
34polyinosinic-polycytidylic acid449.0IL8, IL10, IL1B, IL6
35il 10449.0IL8, IL10, IL6, IL1B
36peptidoglycan44 2810.0IL6, IL1B, IL8, IL10
37ccl344 2810.0IL8, IL10, IL1B, IL6
3815-deoxy-delta-12,14-prostaglandin j2449.0IL10, IL6, IL8, IL1B
39infliximab44 49 1110.9IL6, IL1B, IL10, CRP
40okt3448.8CRP, IL10, IL6
41thalidomide44 49 59 1111.8IL1B, IL6, S100A8, IL10
42simvastatin44 49 59 28 11 2413.6CRP, IL10, IL8, IL6
43etanercept44 49 1110.5IL8, IL6, IL1B, IL10, CRP
44neopterin448.5IL6, IL1B, IL8, IL10, CRP
45sb 20358044 599.4IL10, CRP, IL6, IL8, IL1B
46histamine44 28 2410.3IL8, S100A8, IL1B, IL10, IL6
47methotrexate44 49 1110.3CRP, IL6, IL1B, S100A8, IL10
48ly294002448.2IL6, IL1B, IL8, IL10, ANGPT1, CRP
49vegf447.6CRP, SERPINH1, IL10, IL8, IL1B, MMP8
50nitric oxide44 11 249.6S100A8, ANGPT1, IL10, IL1B, IL8, SERPINH1

GO Terms for genes affiliated with Funisitis

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16Gene Ontology
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Cellular components related to Funisitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055766.3S100A12, S100A8, CRP, ANGPT1, IL8, IL1B
2extracellular spaceGO:0056156.0SERPINH1, COL18A1, S100A8, CRP, ANGPT1, IL10

Biological processes related to Funisitis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1response to molecule of bacterial originGO:0022379.7IL8, IL10
2negative regulation of lipid storageGO:0108889.7IL6, CRP
3positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.1IL10, IL1B, IL6
4defense response to fungusGO:0508329.1S100A8, S100A12
5monocyte chemotaxisGO:0025488.9IL6, S100A12
6negative regulation of cell proliferationGO:0082858.8COL18A1, IL8, IL1B, IL6
7defense response to bacteriumGO:0427428.6IL10, S100A8, S100A12
8neutrophil chemotaxisGO:0305938.3S100A12, S100A8, IL8, IL1B
9positive regulation of NF-kappaB transcription factor activityGO:0510928.3IL6, IL1B, S100A8, S100A12
10inflammatory responseGO:0069547.0IL6, IL1B, IL8, IL10, CRP, S100A8

Molecular functions related to Funisitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.0IL6, IL1B, IL10
2RAGE receptor bindingGO:0507868.8S100A8, S100A12

Products for genes affiliated with Funisitis

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  • Antibodies
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Sources for Funisitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet