Aliases & Classifications for Funisitis

MalaCards integrated aliases for Funisitis:

Name: Funisitis 12 14 69

External Ids:

Disease Ontology 12 DOID:0050698

Summaries for Funisitis

Disease Ontology : 12 A connective tissue disease that is an inflammation of the connective tissue of the umbilical cord.

MalaCards based summary : Funisitis is related to atherosclerosis and spirillary rat-bite fever. An important gene associated with Funisitis is IL6 (Interleukin 6), and among its related pathways/superpathways are PEDF Induced Signaling and TGF-Beta Pathway. The drugs Acetaminophen and Acetylcysteine have been mentioned in the context of this disorder. Affiliated tissues include placenta, testes and lung, and related phenotype is cardiovascular system.

Wikipedia : 72 Funisitis is inflammation of the connective tissue of the umbilical cord, which may cause... more...

Related Diseases for Funisitis

Diseases related to Funisitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 234)
id Related Disease Score Top Affiliating Genes
1 atherosclerosis 28.2 CXCL8 IL10 IL1B IL6 SERPINH1
2 spirillary rat-bite fever 10.6 CXCL8 IL6
3 schwannoma of ureter 10.6 CXCL8 IL6
4 psychotic disorder 10.6 CXCL8 IL6
5 acute myeloblastic leukemia without maturation 10.6 CXCL8 IL6
6 labyrinthine bilateral reactive loss 10.6 CXCL8 IL6
7 pasteurellosis 10.6 CXCL8 IL6
8 cicatricial lagophthalmos 10.6 CXCL8 IL6
9 basidiobolomycosis 10.6 CXCL8 IL10
10 lymph node palisaded myofibroblastoma 10.6 CXCL8 IL10
11 autosomal dominant polycystic kidney disease 10.6 CXCL8 IL6
12 orthostatic proteinuria 10.6 CXCL8 IL6
13 congenital insensitivity to pain with hyperhidrosis 10.6 CXCL8 IL10
14 hidradenitis suppurativa 10.6 CXCL8 IL10
15 nonspecific interstitial pneumonia 10.6 CXCL8 IL10
16 tarsal tunnel syndrome 10.6 CXCL8 IL10
17 urofacial syndrome 1 10.6 CXCL8 IL10
18 lateral cystocele 10.5 CXCL8 IL6
19 plantar wart 10.5 CXCL8 IL10
20 allergic bronchopulmonary aspergillosis 10.5 CXCL8 IL6
21 peroneal nerve paralysis 10.5 IL10 IL6
22 ethmoid sinus adenocarcinoma 10.5 IL10 IL6
23 esophagus leiomyoma 10.5 CXCL8 IL6
24 mycobacterium gordonae 10.5 CXCL8 IL10
25 pneumoconiosis 10.5 CXCL8 IL6
26 distal monosomy 7q36 10.5 CXCL8 IL10
27 lacrimal apparatus disease 10.5 CXCL8 IL1B
28 herpangina 10.5 IL10 IL6
29 chancroid 10.5 CXCL8 IL1B
30 multiple congenital anomalies mental retardation, growth failure and cleft lip palate 10.5 IL10 IL6
31 phlyctenulosis 10.5 IL10 IL6
32 cyclosporiasis 10.5 IL10 IL6
33 amyotrophic lateral sclerosis type 10 10.5 CXCL8 IL1B
34 bardet-biedl syndrome 8 10.5 CXCL8 IL6
35 primary biliary cirrhosis 10.5 IL10 IL6
36 vulvovaginal candidiasis 10.5 CXCL8 SERPINH1
37 hepadnavirus infection 10.5 IL10 IL6
38 epulis 10.5 CXCL8 IL1B
39 gonococcal keratitis 10.5 IL6 SERPINH1
40 ulcerative colitis 10.5 IL10 IL6
41 hemophagocytic lymphohistiocytosis 10.5 IL10 IL6
42 scrotal carcinoma 10.5 IL1B IL6
43 x-linked dominant intellectual disability-epilepsy syndrome 10.5 IL1B IL6
44 congenital nonspherocytic hemolytic anemia 10.4 IL1B IL6
45 upper gum cancer 10.4 IL1B IL6
46 bipolar i disorder 10.4 IL1B IL6
47 eyelid neoplasm 10.4 CXCL8 IL10
48 tinea favosa 10.4 IL1B IL6
49 central nervous system leiomyosarcoma 10.4 IL1B IL6
50 hidradenitis 10.4 CXCL8 IL1B

Graphical network of the top 20 diseases related to Funisitis:



Diseases related to Funisitis

Symptoms & Phenotypes for Funisitis

MGI Mouse Phenotypes related to Funisitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.1 SERPINH1 ANGPT1 IL10 IL1B IL6 SELE

Drugs & Therapeutics for Funisitis

Drugs for Funisitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 1, Phase 2 103-90-2 1983
2
Acetylcysteine Approved, Investigational Phase 1, Phase 2 616-91-1 12035
3 Respiratory System Agents Phase 1, Phase 2
4 N-monoacetylcystine Phase 1, Phase 2
5 Pharmaceutical Solutions Phase 1, Phase 2
6 Anti-Infective Agents Phase 1, Phase 2
7 Expectorants Phase 1, Phase 2
8 Antidotes Phase 1, Phase 2
9 Protective Agents Phase 1, Phase 2,Early Phase 1
10 Antiviral Agents Phase 1, Phase 2
11 Antioxidants Phase 1, Phase 2
12
Oxytocin Approved, Vet_approved 50-56-6 439302 53477758
13
Prednisolone Approved, Vet_approved Early Phase 1 50-24-8 5755
14
Methylprednisolone Approved, Vet_approved Early Phase 1 83-43-2 6741
15 Oxytocics
16 Prednisolone acetate Early Phase 1
17 glucocorticoids Early Phase 1
18 Methylprednisolone acetate Early Phase 1
19 Methylprednisolone Hemisuccinate Early Phase 1
20 Gastrointestinal Agents Early Phase 1
21 Neuroprotective Agents Early Phase 1
22 Hormone Antagonists Early Phase 1
23 Hormones Early Phase 1
24 Hormones, Hormone Substitutes, and Hormone Antagonists Early Phase 1
25 Peripheral Nervous System Agents Early Phase 1
26 Prednisolone hemisuccinate Early Phase 1
27 Prednisolone phosphate Early Phase 1
28 Anti-Inflammatory Agents Early Phase 1
29 Antiemetics Early Phase 1
30 Autonomic Agents Early Phase 1
31 Antineoplastic Agents, Hormonal Early Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 N-acetylcysteine in Intra-amniotic Infection/Inflammation Completed NCT00397735 Phase 1, Phase 2 N-acetylcysteine or placebo
2 FOLCROM Trial: Foley Catheter in Rupture of Membranes Completed NCT01973036 Oxytocin
3 Microbiome And Multi'Omics In Preterm Birth: The Bacteria And Birth Study Recruiting NCT02392650
4 Multimodal Monitoring of Fetal Risk of Inflammation in Preterm Premature Rupture of Membranes Recruiting NCT02702297
5 Maternal Epidural Steroids and Hyperthemia Terminated NCT02212210 Early Phase 1 Methylprednisolone;Normal saline

Search NIH Clinical Center for Funisitis

Genetic Tests for Funisitis

Anatomical Context for Funisitis

MalaCards organs/tissues related to Funisitis:

39
Placenta, Testes, Lung, Neutrophil, Endothelial

Publications for Funisitis

Articles related to Funisitis:

(show top 50) (show all 76)
id Title Authors Year
1
Histological changes in the umbilical artery following severe chorioamnionitis and funisitis may be indicative of early atherosclerosis. ( 28161060 )
2017
2
Funisitis is more common in cervical insufficiency than in preterm labor and preterm premature rupture of membranes. ( 26812854 )
2016
3
Prognostic value of funisitis and/or chorionic vasculitis compared to histologic chorioamnionitis in full-term infants. ( 27023390 )
2016
4
Pro-inflammatory immune responses in leukocytes of premature infants exposed to maternal chorioamnionitis or funisitis. ( 27814345 )
2016
5
Preterm labor and preterm premature rupture of membranes have a different pattern in the involved compartments of acute histologoic chorioamnionitis and/or funisitis: Patho-physiologic implication related to different clinical manifestations. ( 27090052 )
2016
6
Elevated C-reactive protein levels in histological chorioamnionitis at term: impact of funisitis on term neonates. ( 27450900 )
2016
7
Funisitis is associated with adverse neonatal outcome in low-risk unselected deliveries at or near term. ( 26868144 )
2016
8
Histologic Chorioamnionitis and Funisitis After Laser Surgery for Twin-Twin Transfusion Syndrome. ( 27399997 )
2016
9
Differential amniotic fluid cytokine profile in women with chorioamnionitis with and without funisitis. ( 26372455 )
2015
10
A new anti-microbial combination prolongs the latency period, reduces acute histologic chorioamnionitis as well as funisitis, and improves neonatal outcomes in preterm PROM. ( 26373262 )
2015
11
Acute chorioamnionitis and funisitis: definition, pathologic features, and clinical significance. ( 26428501 )
2015
12
Clinical chorioamnionitis at term VI: acute chorioamnionitis and funisitis according to the presence or absence of microorganisms and inflammation in the amniotic cavity. ( 26352071 )
2015
13
Is there a stepwise increase in neonatal morbidities according to histological stage (or grade) of acute chorioamnionitis and funisitis?: effect of gestational age at delivery. ( 25153209 )
2014
14
Acute funisitis is associated with distinct changes in fetal hematologic profile. ( 24863633 )
2014
15
The association between histological chorioamnionitis, funisitis and neonatal outcome in women with preterm prelabor rupture of membranes. ( 23489073 )
2013
16
A fetal and an intra-amniotic inflammatory response is more severe in preterm labor than in preterm PROM in the context of funisitis: unexpected observation in human gestations. ( 23658737 )
2013
17
Postnatal changes of cytokines in premature infants with or without funisitis. ( 24246233 )
2013
18
Low level of tracheal cellular fibronectin in extremely premature infants with funisitis: Relationship with respiratory distress 1 month after birth. ( 24155097 )
2013
19
Pulsation of the fetal splenic vein--a potential ultrasound marker of histological chorioamnionitis and funisitis in women with preterm prelabor rupture of membranes. ( 22574855 )
2012
20
Maternal C-reactive protein at hospital admission is a simple predictor of funisitis in preterm premature rupture of membranes. ( 22710247 )
2012
21
Maternal serum interleukin-6 levels predict impending funisitis in preterm premature rupture of membranes after completion of antibiotics. ( 22046977 )
2012
22
A prediction model of histological chorioamnionitis and funisitis in preterm prelabor rupture of membranes: analyses of multiple proteins in the amniotic fluid. ( 22372866 )
2012
23
Expression of angiogenesis-related factors and inflammatory cytokines in placenta and umbilical vessels in pregnancies with preeclampsia and chorioamnionitis/funisitis. ( 22639995 )
2012
24
Relationship between maternal serum C-reactive protein, funisitis and early-onset neonatal sepsis. ( 22690100 )
2012
25
Funisitis and risk for the development of neonatal respiratory distress syndrome. ( 21531459 )
2011
26
The presence of funisitis is associated with a decreased risk for the development of neonatal respiratory distress syndrome. ( 21216461 )
2011
27
Bleeding per vaginam is associated with funisitis in women with preterm prelabour rupture of the fetal membranes. ( 21392243 )
2011
28
Impact of histological chorioamnionitis, funisitis and clinical chorioamnionitis on neurodevelopmental outcome of preterm infants. ( 21354722 )
2011
29
The frequency and risk factors of funisitis and histologic chorioamnionitis in pregnant women at term who delivered after the spontaneous onset of labor. ( 20698737 )
2011
30
Funisitis and chorionic vasculitis: relation to chorioamnionitis, timing and scoring. ( 22059462 )
2011
31
Correlation between placental histopathology and fetal/neonatal outcome: chorioamnionitis and funisitis are associated to intraventricular haemorrage and retinopathy of prematurity in preterm newborns. ( 20528214 )
2011
32
Neutrophil elastase and interleukin-6 in amniotic fluid as indicators of chorioamnionitis and funisitis. ( 21645958 )
2011
33
Prolonged fetal bradycardia as the presenting clinical sign in congenital syphilis complicated by necrotizing funisitis: a case report. ( 21766037 )
2011
34
Funisitis is associated with increased interleukin-10 gene expression in cord blood mononuclear cells in preterm infants a8o32 weeks of gestation. ( 21183270 )
2011
35
Soluble receptor for advanced glycation end products (sRAGE) in tracheobronchial aspirate fluid and cord blood of very low birth weight infants with chorioamnionitis and funisitis. ( 20727688 )
2010
36
Airway concentrations of angiopoietin-1 and endostatin in ventilated extremely premature infants are decreased after funisitis and unbalanced with bronchopulmonary dysplasia/death. ( 19127216 )
2009
37
Dermatophilus congolensis-associated placentitis, funisitis and abortion in a horse. ( 18405341 )
2008
38
Increased numbers of macrophages in tracheal aspirates in premature infants with funisitis. ( 18353056 )
2008
39
The antenatal identification of funisitis with a rapid MMP-8 bedside test. ( 19127606 )
2008
40
Umbilical cord hematoma: association with chorioamnionitis and funisitis. ( 17611840 )
2007
41
Induction of necrotizing funisitis by fetal administration of intravenous granulocyte-colony stimulating factor and intra-amniotic endotoxin in premature fetal sheep. ( 17957156 )
2007
42
Proteomic biomarkers of intra-amniotic inflammation: relationship with funisitis and early-onset sepsis in the premature neonate. ( 17314690 )
2007
43
Ureaplasma urealyticum and Mycoplasma hominis presence in umbilical cord is associated with pathogenesis of funisitis. ( 18204300 )
2007
44
Chorioamnionitis with or without funisitis increases the risk of hypotension in very low birthweight infants on the first postnatal day but not later. ( 16624881 )
2006
45
The value of cord blood interleukin-6 levels for predicting chorioamnionitis, funisitis and neonatal infection in term premature rupture of membranes. ( 16459014 )
2006
46
Funisitis in term pregnancy is associated with microbial invasion of the amniotic cavity and intra-amniotic inflammation. ( 17127492 )
2006
47
Funisitis and raised interleukin 6 concentrations in gastric aspirates at birth. ( 16036897 )
2005
48
Congenital cutaneous candidiasis with funisitis. ( 15781940 )
2005
49
Activation of umbilical cord endothelial cells and fetal inflammatory response in preterm infants with chorioamnionitis and funisitis. ( 15611353 )
2005
50
Funisitis associated with leptospiral abortion in an equine placenta. ( 16145212 )
2005

Variations for Funisitis

Expression for Funisitis

Search GEO for disease gene expression data for Funisitis.

Pathways for Funisitis

Pathways related to Funisitis according to GeneCards Suite gene sharing:

(show all 47)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.43 ANGPT1 CXCL8 IL10 IL1B IL6
2
Show member pathways
13.32 ANGPT1 CXCL8 IL10 IL1B IL6
3
Show member pathways
13.21 ANGPT1 CXCL8 IL10 IL1B IL6
4
Show member pathways
13.16 ANGPT1 CXCL8 IL10 IL1B IL6
5
Show member pathways
13.1 ANGPT1 CXCL8 IL10 IL1B IL6
6
Show member pathways
12.71 CXCL8 IL10 IL1B IL6
7
Show member pathways
12.68 CXCL8 IL10 IL1B IL6
8
Show member pathways
12.43 ANGPT1 IL10 IL1B IL6
9
Show member pathways
12.41 IL10 IL1B IL6
10
Show member pathways
12.27 IL10 IL1B IL6
11
Show member pathways
12.18 CXCL8 IL1B IL6
12
Show member pathways
12.13 CXCL8 IL1B IL6
13 12.09 IL10 IL1B IL6
14
Show member pathways
12.04 CXCL8 IL1B IL6
15 12.04 CXCL8 IL10 IL1B IL6
16
Show member pathways
12.01 CXCL8 IL10 IL1B IL6
17 11.88 CXCL8 IL1B IL6
18 11.84 CXCL8 IL10 IL1B IL6
19 11.83 IL1B IL6 SELE
20 11.81 CXCL8 IL1B IL6
21
Show member pathways
11.81 IL10 IL1B IL6
22 11.75 CXCL8 IL1B IL6 SELE
23 11.72 CXCL8 IL10 IL1B IL6
24 11.71 CXCL8 IL1B IL6
25 11.67 CXCL8 IL6 SELE
26 11.66 ANGPT1 CXCL8 IL1B IL6
27 11.63 IL10 IL1B IL6
28 11.55 CXCL8 IL10 IL1B IL6
29 11.54 CXCL8 IL1B IL6
30 11.47 CXCL8 IL6 SELE
31 11.46 CXCL8 IL1B IL6
32
Show member pathways
11.42 CXCL8 IL1B IL6 SELE
33 11.41 CXCL8 IL6
34 11.38 IL1B IL6
35 11.34 IL1B IL6
36 11.26 IL10 IL1B IL6
37 11.25 CXCL8 IL10 IL1B IL6
38 11.23 IL1B IL6
39 11.21 CXCL8 IL6
40 11.18 IL1B IL6
41 11.16 IL1B IL6
42 11.16 IL10 IL1B IL6
43 10.94 CXCL8 IL6
44 10.81 IL1B IL6
45 10.8 IL10 IL1B IL6 SELE
46 10.78 ANGPT1 CXCL8 IL10 IL1B IL6
47 10.71 CXCL8 IL10 IL1B IL6 SELE

GO Terms for Funisitis

Cellular components related to Funisitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 ANGPT1 CXCL8 IL10 IL1B IL6 SELE
2 membrane raft GO:0045121 9.13 ANGPT1 SELE SERPINH1

Biological processes related to Funisitis according to GeneCards Suite gene sharing:

(show all 19)
id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.76 CXCL8 IL10 IL1B IL6
2 leukocyte migration GO:0050900 9.71 ANGPT1 IL1B SELE
3 negative regulation of cell proliferation GO:0008285 9.62 CXCL8 IL10 IL1B IL6
4 calcium-mediated signaling GO:0019722 9.58 CXCL8 SELE
5 positive regulation of interleukin-6 production GO:0032755 9.58 IL1B IL6
6 cellular response to lipopolysaccharide GO:0071222 9.58 CXCL8 IL10 IL6
7 positive regulation of nitric oxide biosynthetic process GO:0045429 9.57 IL1B IL6
8 cellular response to estradiol stimulus GO:0071392 9.56 IL10 IL6
9 negative regulation of endothelial cell apoptotic process GO:2000352 9.55 ANGPT1 IL10
10 positive regulation of receptor internalization GO:0002092 9.52 ANGPT1 SELE
11 defense response to protozoan GO:0042832 9.51 IL10 IL6
12 cellular response to hepatocyte growth factor stimulus GO:0035729 9.49 IL10 IL6
13 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.48 ANGPT1 IL1B
14 response to molecule of bacterial origin GO:0002237 9.43 CXCL8 IL10
15 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.43 IL10 IL1B IL6
16 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.37 IL10 IL1B
17 response to lipopolysaccharide GO:0032496 9.26 IL10 IL1B IL6 SELE
18 negative regulation of cytokine secretion involved in immune response GO:0002740 9.16 ANGPT1 IL10
19 inflammatory response GO:0006954 9.02 CXCL8 IL10 IL1B IL6 SELE

Molecular functions related to Funisitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 CXCL8 IL10 IL1B IL6

Sources for Funisitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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