MCID: GLL017
MIFTS: 33

Gallbladder Adenocarcinoma malady

Cancer diseases category
Download this MalaCard

Summaries for Gallbladder Adenocarcinoma

About this section


Fully expand this MalaCard
Disease Ontology:8 A gallbladder carcinoma that derives from epithelial cells of glandular origin.

MalaCards based summary: Gallbladder Adenocarcinoma, also known as adenocarcinoma of the gallbladder, is related to adenocarcinoma and papillary adenocarcinoma. An important gene associated with Gallbladder Adenocarcinoma is MUC2 (mucin 2, oligomeric mucus/gel-forming), and among its related pathways is Amoebiasis. The compounds crcs and ly294002 have been mentioned in the context of this disorder. Affiliated tissues include lymph node, and related mouse phenotype mortality/aging.

Aliases & Classifications for Gallbladder Adenocarcinoma

About this section

Gallbladder Adenocarcinoma, Aliases & Descriptions:

Name: Gallbladder Adenocarcinoma 8 62
 
Adenocarcinoma of the Gallbladder 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:3500
NCIt39 C9166

Related Diseases for Gallbladder Adenocarcinoma

About this section

Diseases related to Gallbladder Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 44)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.1LAMC2, MUC2, XPC, NME1
2papillary adenocarcinoma31.0MUC2, NME1
3gallbladder cancer30.6NME1, MUC2
4adenosquamous carcinoma30.4NME1, MUC2
5gastric adenocarcinoma30.2NME1, MUC2
6adenoma30.1LAMC2, MUC2, NME1
7neuroendocrine carcinoma10.4
8cholecystitis10.4
9large cell neuroendocrine carcinoma10.3
10mucinous adenocarcinoma10.3
11acanthosis nigricans10.3
12xanthogranulomatous cholecystitis10.3
13cervical adenocarcinoma10.2NME1, LAMC2
14laryngeal benign neoplasm10.2MUC2, NME1
15hepatitis10.2
16hepatocellular carcinoma10.2
17gallbladder pleomorphic giant cell adenocarcinoma10.2
18acute interstitial pneumonia10.2
19choledochal cyst10.2
20small cell carcinoma10.2
21pneumonia10.2
22papillary carcinoma10.1NME1, MUC2
23chronic lymphocytic leukemia10.1
24hypertension10.1
25leukemia10.1
26pulmonary hypertension10.1
27ulcerative colitis10.1
28sclerosing cholangitis10.1
29gallbladder adenoma10.1
30gastrointestinal stromal tumor10.1
31cholangitis10.1
32colitis10.1
33intestinal obstruction10.1
34meningitis10.1
35colorectal cancer10.0NME1, MUC2, LAMC2
36lung benign neoplasm10.0XPC, TYK2
37non-small cell lung carcinoma10.0LAMC2, NME1
38bladder carcinoma10.0MUC2, XPC, NME1
39tongue squamous cell carcinoma9.8NME1, XPC, MUC2, LAMC2
40liver cancer9.8MUC2, XPC, NME1
41prostate cancer9.7TYK2, LAMC2, MUC2, XPC
42colonic benign neoplasm9.7NME1, ALDH1A1, MUC2, LAMC2
43breast cancer9.5MUC2, ALDH1A1, XPC, NME1
44lung cancer9.5LAMC2, MUC2, ALDH1A1, XPC, NME1

Graphical network of the top 20 diseases related to Gallbladder Adenocarcinoma:



Diseases related to gallbladder adenocarcinoma

Symptoms for Gallbladder Adenocarcinoma

About this section

Drugs & Therapeutics for Gallbladder Adenocarcinoma

About this section

Drug clinical trials:

Search ClinicalTrials for Gallbladder Adenocarcinoma

Search NIH Clinical Center for Gallbladder Adenocarcinoma

Genetic Tests for Gallbladder Adenocarcinoma

About this section

Anatomical Context for Gallbladder Adenocarcinoma

About this section

MalaCards organs/tissues related to Gallbladder Adenocarcinoma:

32
Lymph node

Animal Models for Gallbladder Adenocarcinoma or affiliated genes

About this section

MGI Mouse Phenotypes related to Gallbladder Adenocarcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.3NME1, XPC, ALDH1A1, MUC2, LAMC2, TYK2

Publications for Gallbladder Adenocarcinoma

About this section

Articles related to Gallbladder Adenocarcinoma:

(show top 50)    (show all 70)
idTitleAuthorsYear
1
Re: metastasis of gallbladder adenocarcinoma to Bauhin's valve: an extremely rare cause of intestinal obstruction. (25246829)
2014
2
Histological phenotype is correlated with the wall-invasion pattern of gallbladder adenocarcinoma. (25355436)
2014
3
Vitamin D receptor genetic variants are associated with susceptibility of gallbladder adenocarcinoma in a Chinese cohort. (25078595)
2014
4
Antiproliferative and apoptosis-inducing activity of curcumin against human gallbladder adenocarcinoma cells. (23645731)
2013
5
Expression of Cell Cycle-Related Proteins, p16, p53 and p63 as Important Prognostic Markers in Gallbladder Adenocarcinoma. (24178677)
2013
6
Cutaneous metastasis of gallbladder adenocarcinoma in a patient with chronic lymphocytic leukemia: a case report and review of the literature. (23467457)
2013
7
Gastrointestinal Stromal Tumor with Synchronous Gallbladder Adenocarcinoma. (23749654)
2013
8
Correlation of S1P1 and ERp29 expression to progression, metastasis, and poor prognosis of gallbladder adenocarcinoma. (23558074)
2013
9
Clinicopathological features and CCT2 and PDIA2 expression in gallbladder squamous/adenosquamous carcinoma and gallbladder adenocarcinoma. (23782473)
2013
10
Secondary Sclerosing Cholangitis due to Gallbladder Adenocarcinoma. (23626514)
2013
11
Coexistence of xanthogranulomatous cholecystitis and gallbladder adenocarcinoma: a fortuitous association? (24471194)
2013
12
Cheek metastasis from gallbladder adenocarcinoma. (23669176)
2013
13
Immunohistochemical expression of phospho-mTOR is associated with poor prognosis in patients with gallbladder adenocarcinoma. (23544944)
2013
14
MTDH and EphA7 are markers for metastasis and poor prognosis of gallbladder adenocarcinoma. (21964981)
2013
15
Expression of MUC1 and MUC4 in gallbladder adenocarcinoma. (23136569)
2012
16
Identification of CD146 expression, angiogenesis, and lymphangiogenesis as progression, metastasis, and poor-prognosis related markers for gallbladder adenocarcinoma. (22076922)
2012
17
Gallbladder adenocarcinoma: evaluation of the prognostic factors in 100 resectable cases in Brazil. (22569972)
2012
18
Mutations in the RAS/RAF/MAP kinase pathway commonly occur in gallbladder adenomas but are uncommon in gallbladder adenocarcinomas. (21307665)
2011
19
Frequency of genetic alterations observed in cell cycle regulatory proteins and microsatellite instability in gallbladder adenocarcinoma: a translational perspective. (21545232)
2011
20
Metastatic gallbladder adenocarcinoma with signet-ring cells: A case report. (21917161)
2011
21
Gallbladder adenocarcinoma with extended intramural spread in adenomyomatosis of the gallbladder with the pearl necklace sign. (21375832)
2011
22
Giant gallbladder: adenocarcinoma complicated with empyema. (21217498)
2011
23
Identification of musashi-1 and ALDH1 as carcinogenesis, progression, and poor-prognosis related biomarkers for gallbladder adenocarcinoma. (22012766)
2010-2011
24
Fatal gemcitabine-induced pulmonary toxicity in metastatic gallbladder adenocarcinoma. (19904536)
2010
25
Invasive micropapillary variant of the gallbladder adenocarcinoma and its aggressive potential for lymph node metastasis. (20460736)
2010
26
National trends in the management and survival of surgically managed gallbladder adenocarcinoma over 15 years: a population-based analysis. (20824371)
2010
27
Gene amplification of Myc and its coamplification with ERBB2 and EGFR in gallbladder adenocarcinoma. (19331129)
2009
28
Factors influencing long-term survival in patients with T3 gallbladder adenocarcinoma. (19329854)
2009
29
Wall-invasion pattern correlates with survival of patients with gallbladder adenocarcinoma. (19331223)
2009
30
Spontaneous necrosis of solid gallbladder adenocarcinoma accompanied with pancreaticobiliary maljunction. (18855999)
2008
31
Mucin-producing gallbladder adenocarcinoma with focal small cell and large cell neuroendocrine differentiation associated with pancreaticobiliary maljunction. (19067853)
2008
32
Gallbladder adenocarcinoma arising in Rokitansky-Aschoff sinus. (19067858)
2008
33
The impact of tumor extent (T stage) and lymph node involvement (N stage) on survival after surgical resection for gallbladder adenocarcinoma. (19088928)
2008
34
Expression of nm23 and KAI1 and their clinical significance in gallbladder adenocarcinoma]. (19024519)
2008
35
Gefitinib, a selective EGFR tyrosine kinase inhibitor, induces apoptosis through activation of Bax in human gallbladder adenocarcinoma cells. (16229013)
2006
36
Clinicopathologic features of gallbladder adenocarcinoma with marked stromal fibrosis--a report of 19 cases]. (16831286)
2006
37
Activated Src and Ras induce gefitinib resistance by activation of signaling pathways downstream of epidermal growth factor receptor in human gallbladder adenocarcinoma cells. (16532343)
2006
38
Meningeal carcinomatosis as the initial manifestation of a gallbladder adenocarcinoma associated with a Krukenberg tumor. (12894314)
2003
39
Resection of triple synchronous tumors--gastric adenocarcinoma, gallbladder adenocarcinoma and stromal tumor of the stomach. (11853221)
2001
40
Fine needle aspiration cytology in xanthogranulomatous cholecystitis, gallbladder adenocarcinoma and coexistent lesions. (10934941)
2000
41
Gallbladder Adenocarcinoma with Florid Neuroendocrine Cell Nests and Extensive Paneth Cell Metaplasia. (12114761)
2000
42
Stromal sialyl Le(a) expression is correlated with vascular invasion of human gallbladder adenocarcinoma. (10853018)
2000
43
v-src induces cisplatin resistance by increasing the repair of cisplatin-DNA interstrand cross-links in human gallbladder adenocarcinoma cells. (10048975)
1999
44
Gallbladder adenocarcinoma and acalculous chronic lymphoplasmacytic cholecystitis associated with ulcerative colitis [corrected]. (8685213)
1996
45
Gallbladder adenocarcinoma with gallstone and calcified ova of clonorchis sinensis--a case report. (8205506)
1994
46
Morphometric analysis of gallbladder adenocarcinoma: discrimination between carcinoma and dysplasia. (2512741)
1989
47
A human gallbladder adenocarcinoma cell line. (2680052)
1989
48
Dysplasia of the gallbladder. Its histogenesis and correlation to gallbladder adenocarcinoma. (2602218)
1989
49
Gallbladder adenocarcinoma: prognostic significance of tumor acid mucopolysaccharide content. (2946897)
1986
50
A human gallbladder adenocarcinoma cell line. (7262900)
1981

Variations for Gallbladder Adenocarcinoma

About this section

Expression for genes affiliated with Gallbladder Adenocarcinoma

About this section
Expression patterns in normal tissues for genes affiliated with Gallbladder Adenocarcinoma

Search GEO for disease gene expression data for Gallbladder Adenocarcinoma.

Pathways for genes affiliated with Gallbladder Adenocarcinoma

About this section

Pathways related to Gallbladder Adenocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7MUC2, LAMC2

Compounds for genes affiliated with Gallbladder Adenocarcinoma

About this section

Compounds related to Gallbladder Adenocarcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1crcs449.8MUC2, NME1
2ly294002449.1XPC, MUC2, TYK2
3Adenosine triphosphate24 1110.0NME1, EPHA7, TYK2
4oligonucleotide448.9NME1, XPC, MUC2
5adp44 28 2410.7TYK2, EPHA7, NME1
6cisplatin44 50 61 1111.6NME1, XPC, ALDH1A1
7retinoic acid44 249.5NME1, ALDH1A1, MUC2, TYK2
8tyrosine448.4TYK2, EPHA7, XPC, NME1

GO Terms for genes affiliated with Gallbladder Adenocarcinoma

About this section

Biological processes related to Gallbladder Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptidyl-tyrosine phosphorylationGO:0181089.4EPHA7, TYK2

Molecular functions related to Gallbladder Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein tyrosine kinase activityGO:0047139.4EPHA7, TYK2
2single-stranded DNA bindingGO:0036979.1NME1, XPC

Products for genes affiliated with Gallbladder Adenocarcinoma

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Gallbladder Adenocarcinoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet