MCID: GLL017
MIFTS: 32

Gallbladder Adenocarcinoma malady

Cancer diseases category

Summaries for Gallbladder Adenocarcinoma

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34MalaCards
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MalaCards: Gallbladder Adenocarcinoma, also known as adenocarcinoma of the gallbladder, is related to adenocarcinoma and papillary adenocarcinoma. An important gene associated with Gallbladder Adenocarcinoma is MUC2 (mucin 2, oligomeric mucus/gel-forming), and among its related pathways is Amoebiasis. The compounds crcs and ly294002 have been mentioned in the context of this disorder. Affiliated tissues include lymph node, and related mouse phenotype mortality/aging.

Aliases & Classifications for Gallbladder Adenocarcinoma

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Sources:
9Disease Ontology, 63UMLS, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

gallbladder adenocarcinoma 9 63
adenocarcinoma of the gallbladder 9


External Ids:

Disease Ontology9 DOID:3500
NCIt41 C9166

Related Diseases for Gallbladder Adenocarcinoma

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Gallbladder Adenocarcinoma:



Diseases related to gallbladder adenocarcinoma

Symptoms for Gallbladder Adenocarcinoma

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Drugs & Therapeutics for Gallbladder Adenocarcinoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Gallbladder Adenocarcinoma

Drug clinical trials:

Search ClinicalTrials for Gallbladder Adenocarcinoma

Search NIH Clinical Center for Gallbladder Adenocarcinoma

Search CenterWatch for Gallbladder Adenocarcinoma

Genetic Tests for Gallbladder Adenocarcinoma

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Anatomical Context for Gallbladder Adenocarcinoma

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34MalaCards
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MalaCards organs/tissues related to Gallbladder Adenocarcinoma:

34
Lymph node

Animal Models for Gallbladder Adenocarcinoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Gallbladder Adenocarcinoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.3NME1, XPC, ALDH1A1, MUC2, LAMC2, TYK2

Publications for Gallbladder Adenocarcinoma

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53PubMed
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Articles related to Gallbladder Adenocarcinoma:

(show top 50)    (show all 66)
idTitleAuthorsYear
1
Antiproliferative and apoptosis-inducing activity of curcumin against human gallbladder adenocarcinoma cells. (23645731)
2013
2
Expression of Cell Cycle-Related Proteins, p16, p53 and p63 as Important Prognostic Markers in Gallbladder Adenocarcinoma. (24178677)
2013
3
Cutaneous metastasis of gallbladder adenocarcinoma in a patient with chronic lymphocytic leukemia: a case report and review of the literature. (23467457)
2013
4
Gastrointestinal Stromal Tumor with Synchronous Gallbladder Adenocarcinoma. (23749654)
2013
5
Correlation of S1P1 and ERp29 expression to progression, metastasis, and poor prognosis of gallbladder adenocarcinoma. (23558074)
2013
6
Clinicopathological features and CCT2 and PDIA2 expression in gallbladder squamous/adenosquamous carcinoma and gallbladder adenocarcinoma. (23782473)
2013
7
Secondary Sclerosing Cholangitis due to Gallbladder Adenocarcinoma. (23626514)
2013
8
Cheek metastasis from gallbladder adenocarcinoma. (23669176)
2013
9
Immunohistochemical expression of phospho-mTOR is associated with poor prognosis in patients with gallbladder adenocarcinoma. (23544944)
2013
10
MTDH and EphA7 are markers for metastasis and poor prognosis of gallbladder adenocarcinoma. (21964981)
2013
11
Impact of adjuvant external beam radiotherapy on survival in surgically resected gallbladder adenocarcinoma: A propensity score-matched Surveillance, Epidemiology, and End Results analysis. (23876364)
2013
12
Expression of p53 upregulated modulator of apoptosis (PUMA) and C-myb in gallbladder adenocarcinoma and their pathological significance. (23475628)
2013
13
Expression of MUC1 and MUC4 in gallbladder adenocarcinoma. (23136569)
2012
14
Identification of CD146 expression, angiogenesis, and lymphangiogenesis as progression, metastasis, and poor-prognosis related markers for gallbladder adenocarcinoma. (22076922)
2012
15
Gallbladder adenocarcinoma: evaluation of the prognostic factors in 100 resectable cases in Brazil. (22569972)
2012
16
Mutations in the RAS/RAF/MAP kinase pathway commonly occur in gallbladder adenomas but are uncommon in gallbladder adenocarcinomas. (21307665)
2011
17
Frequency of genetic alterations observed in cell cycle regulatory proteins and microsatellite instability in gallbladder adenocarcinoma: a translational perspective. (21545232)
2011
18
Metastatic gallbladder adenocarcinoma with signet-ring cells: A case report. (21917161)
2011
19
Gallbladder adenocarcinoma with extended intramural spread in adenomyomatosis of the gallbladder with the pearl necklace sign. (21375832)
2011
20
Giant gallbladder: adenocarcinoma complicated with empyema. (21217498)
2011
21
Overexpression of EZH2 and loss of expression of PTEN is associated with invasion, metastasis, and poor progression of gallbladder adenocarcinoma. (21719208)
2011
22
Identification of musashi-1 and ALDH1 as carcinogenesis, progression, and poor-prognosis related biomarkers for gallbladder adenocarcinoma. (22012766)
2010-2011
23
Fatal gemcitabine-induced pulmonary toxicity in metastatic gallbladder adenocarcinoma. (19904536)
2010
24
Invasive micropapillary variant of the gallbladder adenocarcinoma and its aggressive potential for lymph node metastasis. (20460736)
2010
25
National trends in the management and survival of surgically managed gallbladder adenocarcinoma over 15 years: a population-based analysis. (20824371)
2010
26
Gene amplification of Myc and its coamplification with ERBB2 and EGFR in gallbladder adenocarcinoma. (19331129)
2009
27
Factors influencing long-term survival in patients with T3 gallbladder adenocarcinoma. (19329854)
2009
28
Wall-invasion pattern correlates with survival of patients with gallbladder adenocarcinoma. (19331223)
2009
29
Stromal laminin-5gamma2 chain expression is associated with the wall-invasion pattern of gallbladder adenocarcinoma. (19265264)
2009
30
Spontaneous necrosis of solid gallbladder adenocarcinoma accompanied with pancreaticobiliary maljunction. (18855999)
2008
31
Mucin-producing gallbladder adenocarcinoma with focal small cell and large cell neuroendocrine differentiation associated with pancreaticobiliary maljunction. (19067853)
2008
32
Gallbladder adenocarcinoma arising in Rokitansky-Aschoff sinus. (19067858)
2008
33
The impact of tumor extent (T stage) and lymph node involvement (N stage) on survival after surgical resection for gallbladder adenocarcinoma. (19088928)
2008
34
Expression of nm23 and KAI1 and their clinical significance in gallbladder adenocarcinoma]. (19024519)
2008
35
Gefitinib, a selective EGFR tyrosine kinase inhibitor, induces apoptosis through activation of Bax in human gallbladder adenocarcinoma cells. (16229013)
2006
36
Clinicopathologic features of gallbladder adenocarcinoma with marked stromal fibrosis--a report of 19 cases]. (16831286)
2006
37
Activated Src and Ras induce gefitinib resistance by activation of signaling pathways downstream of epidermal growth factor receptor in human gallbladder adenocarcinoma cells. (16532343)
2006
38
Meningeal carcinomatosis as the initial manifestation of a gallbladder adenocarcinoma associated with a Krukenberg tumor. (12894314)
2003
39
Resection of triple synchronous tumors--gastric adenocarcinoma, gallbladder adenocarcinoma and stromal tumor of the stomach. (11853221)
2001
40
Fine needle aspiration cytology in xanthogranulomatous cholecystitis, gallbladder adenocarcinoma and coexistent lesions. (10934941)
2000
41
Gallbladder Adenocarcinoma with Florid Neuroendocrine Cell Nests and Extensive Paneth Cell Metaplasia. (12114761)
2000
42
Stromal sialyl Le(a) expression is correlated with vascular invasion of human gallbladder adenocarcinoma. (10853018)
2000
43
v-src induces cisplatin resistance by increasing the repair of cisplatin-DNA interstrand cross-links in human gallbladder adenocarcinoma cells. (10048975)
1999
44
Gallbladder adenocarcinoma and acalculous chronic lymphoplasmacytic cholecystitis associated with ulcerative colitis [corrected]. (8685213)
1996
45
Gallbladder adenocarcinoma with gallstone and calcified ova of clonorchis sinensis--a case report. (8205506)
1994
46
Morphometric analysis of gallbladder adenocarcinoma: discrimination between carcinoma and dysplasia. (2512741)
1989
47
A human gallbladder adenocarcinoma cell line. (2680052)
1989
48
Dysplasia of the gallbladder. Its histogenesis and correlation to gallbladder adenocarcinoma. (2602218)
1989
49
Gallbladder adenocarcinoma: prognostic significance of tumor acid mucopolysaccharide content. (2946897)
1986
50
A human gallbladder adenocarcinoma cell line. (7262900)
1981

Variations for Gallbladder Adenocarcinoma

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Expression for genes affiliated with Gallbladder Adenocarcinoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gallbladder Adenocarcinoma

Search GEO for disease gene expression data for Gallbladder Adenocarcinoma.

Pathways for genes affiliated with Gallbladder Adenocarcinoma

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51PathCards, 31KEGG
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Pathways related to Gallbladder Adenocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7MUC2, LAMC2

Compounds for genes affiliated with Gallbladder Adenocarcinoma

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Sources:
46Novoseek, 25HMDB, 12DrugBank, 30IUPHAR, 52PharmGKB, 62Tocris Bioscience
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Compounds related to Gallbladder Adenocarcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1crcs469.8MUC2, NME1
2ly294002469.1XPC, MUC2, TYK2
3Adenosine triphosphate25 1210.0NME1, EPHA7, TYK2
4oligonucleotide468.9NME1, XPC, MUC2
5adp46 30 2510.7TYK2, EPHA7, NME1
6cisplatin46 52 62 1211.6NME1, XPC, ALDH1A1
7retinoic acid46 259.5NME1, ALDH1A1, MUC2, TYK2
8tyrosine468.4TYK2, EPHA7, XPC, NME1

GO Terms for genes affiliated with Gallbladder Adenocarcinoma

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17Gene Ontology
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Biological processes related to Gallbladder Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptidyl-tyrosine phosphorylationGO:0181089.4EPHA7, TYK2

Molecular functions related to Gallbladder Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein tyrosine kinase activityGO:0047139.4EPHA7, TYK2
2single-stranded DNA bindingGO:0036979.1NME1, XPC

Products for genes affiliated with Gallbladder Adenocarcinoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gallbladder Adenocarcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet