MCID: GLL029
MIFTS: 29

Gallbladder Adenoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Gallbladder Adenoma

MalaCards integrated aliases for Gallbladder Adenoma:

Name: Gallbladder Adenoma 12 52 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0050893

Summaries for Gallbladder Adenoma

Disease Ontology : 12 A biliary tract neoplasm that has material basis in epithelial tissue of glandular origin located in the gallbladder.

MalaCards based summary : Gallbladder Adenoma is related to gastrointestinal neuroendocrine tumor and autosomal recessive leukoencephalopathy-ischemic stroke-retinitis pigmentosa syndrome. An important gene associated with Gallbladder Adenoma is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways are Pathways in cancer and HTLV-I infection. The drugs Cisplatin and Doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include testes, and related phenotypes are embryo and pigmentation

Related Diseases for Gallbladder Adenoma

Diseases related to Gallbladder Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)
id Related Disease Score Top Affiliating Genes
1 gastrointestinal neuroendocrine tumor 10.3 CDKN2A CTNNB1
2 autosomal recessive leukoencephalopathy-ischemic stroke-retinitis pigmentosa syndrome 10.3 CDKN2A CTNNB1
3 rare endometriosis 10.2 CDKN2A CTNNB1
4 pancreatic somatostatinoma 10.2 CDKN2A CTNNB1
5 tracheal disease 10.2 CDKN2A CTNNB1
6 male reproductive organ benign neoplasm 10.2 CDKN2A CTNNB1
7 endometriosis of uterus 10.2 CDKN2A CTNNB1
8 trachea squamous cell carcinoma 10.2 CDKN2A CTNNB1
9 exertional headache 10.2 CDKN2A RB1
10 adenoma 10.2
11 paroxysmal nocturnal hemoglobinuria 10.1 CDKN2A CTNNB1
12 unilateral retinoblastoma 10.1 CDKN2A RB1
13 pharynx cancer 10.1 CDKN2A RB1
14 bardet-biedl syndrome 10.1 CDKN2A CTNNB1
15 post-surgical hypoinsulinemia 10.1 CDKN2A RB1
16 gallbladder cancer 10.1 CDKN2A CTNNB1
17 small cell sarcoma 10.1 CDKN2A RB1
18 brown-vialetto-van laere syndrome 10.1 CDKN2A CTNNB1
19 accessory nerve disease 10.0 CDKN2A RB1
20 nail disorder, nonsyndromic congenital, 1 10.0 CDKN2A CTNNB1
21 villous adenoma 10.0 CDKN2A CTNNB1
22 acute porphyria 9.9 CDKN2A CTNNB1
23 gastric cancer, somatic 9.9 CDKN2A CTNNB1
24 small cell cancer of the lung, somatic 9.8 CDKN2A RB1
25 adenocarcinoma 9.8
26 autonomic nervous system neoplasm 9.7 CDKN2A RB1
27 juxtacortical chondrosarcoma 9.6 CDKN2A CTNNB1 RB1
28 esophagus lymphoma 9.6 CDKN2A CTNNB1 RB1
29 sertoli-leydig cell tumor 9.6 CDKN2A CTNNB1 RB1
30 gallbladder adenocarcinoma 9.6
31 nail disorder, nonsyndromic congenital, 3, 9.6 CDKN2A CTNNB1 RB1
32 lethal congenital contracture syndrome 10 9.5 CDKN2A CTNNB1 RB1
33 ladd syndrome 9.5 CDKN2A RB1
34 bone ameloblastoma 8.3 CDKN2A CTNNB1 PCNT PFN1 RB1

Graphical network of the top 20 diseases related to Gallbladder Adenoma:



Diseases related to Gallbladder Adenoma

Symptoms & Phenotypes for Gallbladder Adenoma

MGI Mouse Phenotypes related to Gallbladder Adenoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.46 CDKN2A CTNNB1 PFN1 RB1
2 pigmentation MP:0001186 9.13 CTNNB1 RB1 CDKN2A
3 vision/eye MP:0005391 8.92 CDKN2A CTNNB1 PFN1 RB1

Drugs & Therapeutics for Gallbladder Adenoma

Drugs for Gallbladder Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
2
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
3
Doxil Approved June 1999 Phase 2 31703
4 Alkylating Agents Phase 2
5 Anti-Bacterial Agents Phase 2
6 Antibiotics, Antitubercular Phase 2
7 Mitomycins Phase 2
8 Nucleic Acid Synthesis Inhibitors Phase 2
9 Topoisomerase Inhibitors Phase 2
10
Carboplatin Approved Phase 1 41575-94-4 10339178 498142 38904
11
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
12
Trastuzumab Approved, Investigational Phase 1 180288-69-1 9903
13 Adjuvants, Immunologic Phase 1
14 Albumin-Bound Paclitaxel Phase 1
15 Angiogenesis Inhibitors Phase 1
16 Angiogenesis Modulating Agents Phase 1
17 Antimitotic Agents Phase 1
18 Antineoplastic Agents, Phytogenic Phase 1
19 Interleukin-12 Phase 1
20 Vaccines Phase 1
21
Pancrelipase Approved 53608-75-6
22
Gemcitabine Approved 95058-81-4 60750
23
Oxaliplatin Approved, Investigational 61825-94-3 5310940 9887054 43805 6857599
24 insulin
25 Insulin, Globin Zinc
26 pancreatin
27 Pharmaceutical Solutions

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Clinical Trial of Intraperitoneal Hyperthermic Chemotherapy Recruiting NCT02349958 Phase 2
2 Interleukin-12 and Trastuzumab in Treating Patients With Cancer That Has High Levels of HER2/Neu Completed NCT00004074 Phase 1
3 Safety and Immune Response to a Multi-component Immune Based Therapy (MKC1106-PP) for Patients With Advanced Cancer. Completed NCT00423254 Phase 1
4 Quantificational Enhancement Pattern Analysis Using a Novel Software "Vuebox" of Contrast-enhanced Harmonic Endoscopic Ultrasonography for Differential Diagnosis Between Adenomas and Cholesterol Polyps Unknown status NCT02492685
5 Laparoscopy to Remove Pancreatic Tumors (Insulinomas) Completed NCT00005910
6 The Role of Different Imaging Methods in the Diagnosis of Gallbladder Polyps Recruiting NCT02762227
7 The Role of ctDNA and PBMC in Treatment of Biliary Tract Cancer Recruiting NCT02809898
8 Efficacy of Cap-assisted Chromoendoscopy as a Screening Test for Colorectal Neoplasm Using Web-based Research Network Recruiting NCT01112280
9 International Registry of Patients Treated With Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) Recruiting NCT03210298
10 Integrated Cancer Repository for Cancer Research Recruiting NCT02012699

Search NIH Clinical Center for Gallbladder Adenoma

Genetic Tests for Gallbladder Adenoma

Anatomical Context for Gallbladder Adenoma

MalaCards organs/tissues related to Gallbladder Adenoma:

39
Testes

Publications for Gallbladder Adenoma

Articles related to Gallbladder Adenoma:

(show all 11)
id Title Authors Year
1
Contrast-enhanced ultrasound in diagnosis of gallbladder adenoma. ( 25865694 )
2015
2
Value of contrast-enhanced ultrasound in the differential diagnosis between gallbladder adenoma and gallbladder adenoma canceration. ( 25785101 )
2015
3
Contrast-enhanced ultrasound may distinguish gallbladder adenoma from cholesterol polyps: a prospective case-control study. ( 26082060 )
2015
4
Mutations in the RAS/RAF/MAP kinase pathway commonly occur in gallbladder adenomas but are uncommon in gallbladder adenocarcinomas. ( 21307665 )
2011
5
Gallbladder adenoma with focal adenocarcinoma. ( 18717288 )
2008
6
A case of pyloric-type gallbladder adenoma. ( 18392262 )
2008
7
Gallbladder adenoma: report of a case with emphasis on contrast-enhanced US findings. ( 16447086 )
2006
8
Genetic alterations in gallbladder adenoma, dysplasia and carcinoma. ( 11410326 )
2001
9
More frequent beta-catenin exon 3 mutations in gallbladder adenomas than in carcinomas indicate different lineages. ( 11196159 )
2001
10
Gallbladder adenomas have molecular abnormalities different from those present in gallbladder carcinomas. ( 9923922 )
1999
11
Histological and genetic changes in malignant transformation of gallbladder adenoma. ( 10436806 )
1999

Variations for Gallbladder Adenoma

Cosmic variations for Gallbladder Adenoma:

9 (show all 15)
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM553 KRAS biliary tract,gallbladder,other,adenoma c.182A>T p.Q61L 6
2 COSM520 KRAS biliary tract,gallbladder,other,adenoma c.35G>T p.G12V 6
3 COSM517 KRAS biliary tract,gallbladder,other,adenoma c.34G>A p.G12S 6
4 COSM552 KRAS biliary tract,gallbladder,other,adenoma c.182A>G p.Q61R 6
5 COSM521 KRAS biliary tract,gallbladder,other,adenoma c.35G>A p.G12D 6
6 COSM554 KRAS biliary tract,gallbladder,other,adenoma c.183A>C p.Q61H 6
7 COSM516 KRAS biliary tract,gallbladder,other,adenoma c.34G>T p.G12C 6
8 COSM5679 CTNNB1 biliary tract,gallbladder,other,adenoma c.110C>G p.S37C 6
9 COSM5664 CTNNB1 biliary tract,gallbladder,other,adenoma c.121A>G p.T41A 6
10 COSM5667 CTNNB1 biliary tract,gallbladder,other,adenoma c.134C>T p.S45F 6
11 COSM5662 CTNNB1 biliary tract,gallbladder,other,adenoma c.110C>T p.S37F 6
12 COSM5670 CTNNB1 biliary tract,gallbladder,other,adenoma c.101G>T p.G34V 6
13 COSM5672 CTNNB1 biliary tract,gallbladder,other,adenoma c.94G>A p.D32N 6
14 COSM5676 CTNNB1 biliary tract,gallbladder,other,adenoma c.122C>T p.T41I 6
15 COSM5677 CTNNB1 biliary tract,gallbladder,other,adenoma c.98C>G p.S33C 6

Expression for Gallbladder Adenoma

Search GEO for disease gene expression data for Gallbladder Adenoma.

Pathways for Gallbladder Adenoma

GO Terms for Gallbladder Adenoma

Biological processes related to Gallbladder Adenoma according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.63 CDKN2A CTNNB1 RB1
2 regulation of transcription from RNA polymerase II promoter GO:0006357 9.58 CTNNB1 PFN1 RB1
3 negative regulation of transcription, DNA-templated GO:0045892 9.54 CDKN2A CTNNB1 RB1
4 negative regulation of protein kinase activity GO:0006469 9.49 CDKN2A RB1
5 G1/S transition of mitotic cell cycle GO:0000082 9.48 CDKN2A RB1
6 negative regulation of cell proliferation GO:0008285 9.43 CDKN2A CTNNB1 RB1
7 Ras protein signal transduction GO:0007265 9.32 CDKN2A RB1
8 cellular response to growth factor stimulus GO:0071363 9.16 CTNNB1 PFN1
9 regulation of G2/M transition of mitotic cell cycle GO:0010389 9.13 CDKN2A
10 androgen receptor signaling pathway GO:0030521 8.96 CTNNB1 RB1
11 positive regulation of transcription from RNA polymerase II promoter GO:0045944 8.92 CDKN2A CTNNB1 PFN1 RB1

Molecular functions related to Gallbladder Adenoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 kinase binding GO:0019900 9.32 CTNNB1 RB1
2 androgen receptor binding GO:0050681 9.26 CTNNB1 RB1
3 RNA polymerase II activating transcription factor binding GO:0001102 9.16 CTNNB1 RB1
4 transcription factor binding GO:0008134 9.13 CDKN2A CTNNB1 RB1
5 disordered domain specific binding GO:0097718 8.62 CTNNB1 RB1

Sources for Gallbladder Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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