MCID: GLL029
MIFTS: 27

Gallbladder Adenoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Gallbladder Adenoma

MalaCards integrated aliases for Gallbladder Adenoma:

Name: Gallbladder Adenoma 12 51 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0050893
UMLS 69 C0238137

Summaries for Gallbladder Adenoma

Disease Ontology : 12 A biliary tract neoplasm that has material basis in epithelial tissue of glandular origin located in the gallbladder.

MalaCards based summary : Gallbladder Adenoma is related to adenocarcinoma and adenoma. An important gene associated with Gallbladder Adenoma is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways are Pathways in cancer and Gastric cancer. Affiliated tissues include the gallbladder, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Gallbladder Adenoma

Graphical network of the top 20 diseases related to Gallbladder Adenoma:



Diseases related to Gallbladder Adenoma

Symptoms & Phenotypes for Gallbladder Adenoma

GenomeRNAi Phenotypes related to Gallbladder Adenoma according to GeneCards Suite gene sharing:

25 (show all 23)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.75 RB1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.75 CTNNB1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.75 CTNNB1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.75 NONO
5 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.75 RB1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.75 NONO
7 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.75 RB1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.75 NONO
9 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.75 NONO
10 Increased shRNA abundance (Z-score > 2) GR00366-A-172 9.75 RB1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.75 CTNNB1 NONO RB1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-197 9.75 CTNNB1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.75 NONO
14 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.75 RB1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.75 RB1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.75 CTNNB1 NONO
17 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.75 CTNNB1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.75 RB1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.75 RB1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.75 CTNNB1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.75 CTNNB1
22 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.75 CTNNB1 NONO
23 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.75 CTNNB1

MGI Mouse Phenotypes related to Gallbladder Adenoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.55 CDKN2A CTNNB1 NONO PFN1 RB1
2 liver/biliary system MP:0005370 9.26 CDKN2A CTNNB1 NONO RB1
3 pigmentation MP:0001186 8.8 CDKN2A CTNNB1 RB1

Drugs & Therapeutics for Gallbladder Adenoma

Search Clinical Trials , NIH Clinical Center for Gallbladder Adenoma

Genetic Tests for Gallbladder Adenoma

Anatomical Context for Gallbladder Adenoma

The Foundational Model of Anatomy Ontology organs/tissues related to Gallbladder Adenoma:

18
The Gallbladder

Publications for Gallbladder Adenoma

Articles related to Gallbladder Adenoma:

(show all 11)
# Title Authors Year
1
Contrast-enhanced ultrasound in diagnosis of gallbladder adenoma. ( 25865694 )
2015
2
Value of contrast-enhanced ultrasound in the differential diagnosis between gallbladder adenoma and gallbladder adenoma canceration. ( 25785101 )
2015
3
Contrast-enhanced ultrasound may distinguish gallbladder adenoma from cholesterol polyps: a prospective case-control study. ( 26082060 )
2015
4
Mutations in the RAS/RAF/MAP kinase pathway commonly occur in gallbladder adenomas but are uncommon in gallbladder adenocarcinomas. ( 21307665 )
2011
5
A case of pyloric-type gallbladder adenoma. ( 18392262 )
2008
6
Gallbladder adenoma with focal adenocarcinoma. ( 18717288 )
2008
7
Gallbladder adenoma: report of a case with emphasis on contrast-enhanced US findings. ( 16447086 )
2006
8
More frequent beta-catenin exon 3 mutations in gallbladder adenomas than in carcinomas indicate different lineages. ( 11196159 )
2001
9
Genetic alterations in gallbladder adenoma, dysplasia and carcinoma. ( 11410326 )
2001
10
Histological and genetic changes in malignant transformation of gallbladder adenoma. ( 10436806 )
1999
11
Gallbladder adenomas have molecular abnormalities different from those present in gallbladder carcinomas. ( 9923922 )
1999

Variations for Gallbladder Adenoma

Cosmic variations for Gallbladder Adenoma:

9 (show all 15)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM520 KRAS biliary tract,gallbladder,other,adenoma c.35G>T p.G12V 6
2 COSM553 KRAS biliary tract,gallbladder,other,adenoma c.182A>T p.Q61L 6
3 COSM517 KRAS biliary tract,gallbladder,other,adenoma c.34G>A p.G12S 6
4 COSM552 KRAS biliary tract,gallbladder,other,adenoma c.182A>G p.Q61R 6
5 COSM521 KRAS biliary tract,gallbladder,other,adenoma c.35G>A p.G12D 6
6 COSM554 KRAS biliary tract,gallbladder,other,adenoma c.183A>C p.Q61H 6
7 COSM516 KRAS biliary tract,gallbladder,other,adenoma c.34G>T p.G12C 6
8 COSM5677 CTNNB1 biliary tract,gallbladder,other,adenoma c.98C>G p.S33C 6
9 COSM5679 CTNNB1 biliary tract,gallbladder,other,adenoma c.110C>G p.S37C 6
10 COSM5664 CTNNB1 biliary tract,gallbladder,other,adenoma c.121A>G p.T41A 6
11 COSM5667 CTNNB1 biliary tract,gallbladder,other,adenoma c.134C>T p.S45F 6
12 COSM5662 CTNNB1 biliary tract,gallbladder,other,adenoma c.110C>T p.S37F 6
13 COSM5670 CTNNB1 biliary tract,gallbladder,other,adenoma c.101G>T p.G34V 6
14 COSM5672 CTNNB1 biliary tract,gallbladder,other,adenoma c.94G>A p.D32N 6
15 COSM5676 CTNNB1 biliary tract,gallbladder,other,adenoma c.122C>T p.T41I 6

Expression for Gallbladder Adenoma

Search GEO for disease gene expression data for Gallbladder Adenoma.

Pathways for Gallbladder Adenoma

GO Terms for Gallbladder Adenoma

Biological processes related to Gallbladder Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of transcription by RNA polymerase II GO:0006357 9.54 CTNNB1 PFN1 RB1
2 negative regulation of cell proliferation GO:0008285 9.33 CDKN2A CTNNB1 RB1
3 regulation of G2/M transition of mitotic cell cycle GO:0010389 9.32 CDKN2A PCNT
4 Ras protein signal transduction GO:0007265 9.26 CDKN2A RB1
5 androgen receptor signaling pathway GO:0030521 8.96 CTNNB1 RB1
6 negative regulation of transcription, DNA-templated GO:0045892 8.92 CDKN2A CTNNB1 NONO RB1

Molecular functions related to Gallbladder Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kinase binding GO:0019900 9.37 CTNNB1 RB1
2 transcription factor binding GO:0008134 9.33 CDKN2A CTNNB1 RB1
3 core promoter binding GO:0001047 9.32 NONO RB1
4 androgen receptor binding GO:0050681 9.26 CTNNB1 RB1
5 RNA polymerase II activating transcription factor binding GO:0001102 8.96 CTNNB1 RB1
6 disordered domain specific binding GO:0097718 8.8 CDKN2A CTNNB1 RB1

Sources for Gallbladder Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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