MCID: GLL018
MIFTS: 58

Gallbladder Cancer malady

Rare diseases, Cancer diseases, Liver diseases, Nephrological diseases, Gastrointestinal diseases categories

Summaries for Gallbladder Cancer

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MedlinePlus:32 Your gallbladder is a pear-shaped organ under your liver. it stores bile, a fluid made by your liver to digest fat. as your stomach and intestines digest food, your gallbladder releases bile through a tube called the common bile duct. the duct connects your gallbladder and liver to your small intestine. cancer of the gallbladder is rare. it is more common in women and native americans. symptoms include jaundice (yellowing of the skin and whites of the eyes) pain above the stomach fever nausea and vomiting bloating lumps in the abdomen it is hard to diagnose gallbladder cancer in its early stages. sometimes doctors find it when they remove the gallbladder for another reason. but people with gallstones rarely have gallbladder cancer. because it is often found late, it can be hard to treat gallbladder cancer. treatment options include surgery, chemotherapy, radiation, or a combination. nih: national cancer institute

MalaCards based summary: Gallbladder Cancer, also known as gallbladder carcinoma, is related to cholangiocarcinoma and gallbladder disease, and has symptoms including biliary tract neoplasm, abdominal pain and anorexia. An important gene associated with Gallbladder Cancer is HPSE (heparanase), and among its related pathways are NTHi-Induced Signaling and Pyrimidine metabolism. The compounds 5-fluorocytosine and iudr have been mentioned in the context of this disorder. Affiliated tissues include the gallbladder, liver and lymph node, and related mouse phenotypes are tumorigenesis and endocrine/exocrine gland.

Disease Ontology:9 A biliary tract cancer that is located in the gallbladder.

Wikipedia:63 Gallbladder cancer is a relatively uncommon cancer. It has peculiar geographical distribution being... more...

Aliases & Classifications for Gallbladder Cancer

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 47Orphanet, 32MedlinePlus, 60UMLS, 41NIH Rare Diseases, 55SNOMED-CT, 33MeSH, 38NCIt, 61UMLS via Orphanet, 26ICD10 via Orphanet, 25ICD10
See all sources

Gallbladder Cancer, Aliases & Descriptions:

Name: Gallbladder Cancer 9 11 43 47 32
Gallbladder Carcinoma 9 11 43 60
Malignant Neoplasm of Gallbladder 9 60
Gallbladder Neoplasm 9 60
Malignant Neoplasm of Gallbladder Localized 60
Localized Malignant Gallbladder Neoplasm 9
Malignant Tumor of the Gallbladder 9
Malignant Tumour of Gallbladder 9
 
Carcinoma of the Gallbladder 47
Cancer of the Gallbladder 9
Carcinoma of Gallbladder 9
Tumor of the Gallbladder 9
Carcinoma Gallbladder 9
Gall Bladder Cancer 41
Gallbladder Ca 9
Gbc 47


Classifications:



Characteristics (Orphanet epidemiological data):

47
gallbladder cancer:
Inheritance: Not applicable; Prevalence: 1-5/10000 (Worldwide); Age of onset: Adult


External Ids:

Disease Ontology9 DOID:3121, DOID:4948
MeSH33 D005706
NCIt38 C3048, C3844
Orphanet47 56044
UMLS via Orphanet61 C0235782
ICD10 via Orphanet26 C23
ICD1025 C23

Related Diseases for Gallbladder Cancer

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Diseases related to Gallbladder Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 140)
idRelated DiseaseScoreTop Affiliating Genes
1cholangiocarcinoma31.1CDX2, PSG2, MUC2
2gallbladder disease30.7MUC2, CCKAR
3ulcerative colitis30.4MUC2, APC, MLH1
4cholelithiasis30.3PSG2, CYP7A1
5lung cancer30.0TYMS, TGFBR2, PSG2, CDX2
6retinoblastoma29.9TGFBR2, APC, TYMS
7melanoma29.7CDX2, HPSE, PSG2, MLH1
8adenoma29.6MLH1, APC, TGFBR2, MUC2, PSG2, CDX2
9breast cancer29.4TYMS, TGFBR2, MUC2, PSG2, DPYD, HPSE
10hepatocellular carcinoma29.3APC, TGFBR2, MUC2, PSG2, DPYD, HPSE
11adenocarcinoma28.7MLH1, TYMS, CDX2, HPSE, DPYD, CCKAR
12cholecystitis10.7
13adenosquamous carcinoma10.6
14xanthogranulomatous cholecystitis10.6
15spindle cell carcinoma10.6
16hepatitis10.5
17ampulla of vater carcinoma10.5MUC2
18large cell neuroendocrine carcinoma10.5
19adult acute lymphocytic leukemia10.4TYMS
20pseudomyxoma peritonei10.4MUC2, CDX2
21dihydropyrimidine dehydrogenase deficiency10.4DPYD
22pleomorphic carcinoma10.4
23endotheliitis10.3
24bronchiolo-alveolar adenocarcinoma10.3MUC2, CDX2
25gastritis10.3CDX2, MLH1
26intestinal neoplasm10.3APC, CDX2
27tubular adenocarcinoma10.3CDX2, MUC2
28adenosquamous gallbladder carcinoma10.3
29pancreatitis10.3
30mismatch repair cancer syndrome10.3MLH1, APC
31gastrointestinal stromal tumor10.3
32neuroendocrine tumor10.3
33endometrial cancer10.3CDX2, MLH1
34laryngeal carcinoma10.3PSG2, MUC2
35duodenitis10.2
36rectal neoplasm10.2TYMS, DPYD
37pancreas disease10.2PSG2, CCKAR
38bacteremia10.2
39h. pylori infection10.2
40gastrointestinal system disease10.2CCKAR, PSG2
41gallbladder endocrine tumor10.2
42factor vii deficiency10.2TYMS, PSG2
43barrett esophagus/esophageal adenocarcinoma10.2CDX2, MUC2, APC
44bladder cancer, somatic10.2TYMS, MUC2, PSG2
45stomatitis10.2DPYD, TYMS
46mucoepidermoid carcinoma10.2PSG2, MUC2, TGFBR2
47hypoxia10.2
48ileus10.2
49obesity10.1
50abdominal aortic aneurysm10.1

Graphical network of the top 20 diseases related to Gallbladder Cancer:



Diseases related to gallbladder cancer

Symptoms for Gallbladder Cancer

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Symptoms:

 47
  • extrahepatic biliary tract/gallbladder neoplasm/tumor/carcinoma/cancer
  • acute abdominal pain/colic
  • anorexia
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • hepatitis/icterus/cholestasis
  • lymphadenopathy/polyadenopathies

HPO human phenotypes related to Gallbladder Cancer:

id Description Frequency HPO Source Accession
1 biliary tract neoplasm hallmark (90%) HP:0100574
2 abdominal pain typical (50%) HP:0002027
3 anorexia typical (50%) HP:0002039
4 nausea and vomiting occasional (7.5%) HP:0002017
5 lymphadenopathy occasional (7.5%) HP:0002716

Drugs & Therapeutics for Gallbladder Cancer

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Drug clinical trials:

Search ClinicalTrials for Gallbladder Cancer

Search NIH Clinical Center for Gallbladder Cancer

Genetic Tests for Gallbladder Cancer

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Anatomical Context for Gallbladder Cancer

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MalaCards organs/tissues related to Gallbladder Cancer:

31
Liver, Lymph node, Eye, Skin, Small intestine, Endothelial, Lung, Pancreas, Testes, Bone marrow, Bone, Colon, Thyroid, Prostate

FMA organs/tissues related to Gallbladder Cancer:

14
The gallbladder

Animal Models for Gallbladder Cancer or affiliated genes

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MGI Mouse Phenotypes related to Gallbladder Cancer:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7MLH1, APC, TGFBR2, MUC2, CDX2
2MP:00053798.0MLH1, APC, TGFBR2, MUC2, CCKAR, HPSE
3MP:00053787.9CDX2, CCKAR, MUC2, TGFBR2, APC, CYP7A1
4MP:00053847.9MLH1, APC, TGFBR2, MUC2, CCKAR, CDX2
5MP:00053817.7CDX2, MLH1, CYP7A1, APC, TGFBR2, MUC2
6MP:00053767.5MLH1, CYP7A1, APC, TGFBR2, MUC2, CCKAR
7MP:00107687.1MLH1, CYP7A1, APC, TGFBR2, MUC2, CDX2

Publications for Gallbladder Cancer

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Articles related to Gallbladder Cancer:

(show top 50)    (show all 549)
idTitleAuthorsYear
1
SPOCK1 as a potential cancer prognostic marker promotes the proliferation and metastasis of gallbladder cancer cells by activating the PI3K/AKT pathway. (25623055)
2015
2
Targeting specific molecular pathways holds promise for advanced gallbladder cancer therapy. (25639632)
2015
3
Curative resection of gallbladder cancer with liver invasion and hepatic metastasis after chemotherapy with gemcitabine plus S-1: report of a case. (25367161)
2014
4
Gallbladder cancer. (25392833)
2014
5
Risk factors of lymphatic metastasis complement poor radiological detection in gallbladder cancer. (24415884)
2014
6
Simultaneous occurrence of gallbladder cancer in a laundry couple: association between gallbladder cancer and benzene. (23458990)
2013
7
Unsuspected gallbladder cancer: a clinical retrospective study. (24206403)
2013
8
Gallbladder wall calcification and gallbladder cancer. (23683783)
2013
9
Recent advances in systemic therapies and radiotherapy for gallbladder cancer. (23290830)
2013
10
Role of routine 16b1 lymph node biopsy in the management of gallbladder cancer: an analysis. (23869478)
2013
11
Prognostic significance of nemo-like kinase (NLK) expression in patients with gallbladder cancer. (23857283)
2013
12
Risk factors for gallbladder cancer: a case-control study. (22890893)
2013
13
Letter Re: Gallbladder cancer involving the extrahepatic bile duct is worthy of resection. (23728286)
2013
14
Gallbladder cancer in the Netherlands: incidence, treatment and survival patterns since 1989. (22441693)
2012
15
Gallbladder cancer, a vanishing disease? (22926299)
2012
16
Significant role of estrogen and progesterone receptor sequence variants in gallbladder cancer predisposition: a multi-analytical strategy. (22808109)
2012
17
Analysis of the relationships between clinicopathologic factors and survival in gallbladder cancer following surgical resection with curative intent. (23300551)
2012
18
Incidental gallbladder cancer diagnosed during or after laparoscopic cholecystectomy in members of the Turkish population with gallstone disease. (22234759)
2011
19
Risk factors of gallbladder cancer in Karachi-a case-control study. (22151791)
2011
20
Incidentally-discovered gallbladder cancer: When, why and which reoperation? (21478068)
2011
21
Outcome of adjuvant therapy for gallbladder cancer. (21212704)
2010
22
Comparative analysis between clinical outcomes of primary radical resection and second completion radical resection for T2 gallbladder cancer: single-center experience. (20333380)
2010
23
Iodine-125 biliary stent for palliative treatment of locally advanced gallbladder cancer. (20931472)
2010
24
Metastatic gallbladder cancer presenting as a gingival tumor and deep neck infection. (20950782)
2010
25
Does gallbladder cancer divide India? (20373078)
2010
26
Segmental hepatic resection (segments IVb-V) with lymph node dissection for gallbladder cancer. (20595073)
2010
27
Comment on: Lifestyle, reproductive factors and risk of gallbladder cancer. (19960170)
2009
28
Evolving treatment strategies for gallbladder cancer. (19495882)
2009
29
Complement receptor 1 (A3650G RsaI and intron 27 HindIII) polymorphisms and risk of gallbladder cancer in north Indian population. (19906204)
2009
30
Gallbladder cancer. (18466866)
2008
31
Lifestyle, reproductive factors and risk of gallbladder cancer. (19037558)
2008
32
Prognostic factors for gallbladder cancer in Japan. (18948808)
2008
33
Treatment considerations for gallbladder cancer should include extent of surgery. (18802170)
2008
34
Gallbladder cancer and radical surgery. (18791371)
2008
35
Survival prediction models for estimating the benefit of post-operative radiation therapy for gallbladder cancer and lung cancer. (18999217)
2008
36
IL-1 gene polymorphisms and genetic susceptibility of gallbladder cancer in a north Indian population. (18940468)
2008
37
Gallbladder cancer: the basics. (21960896)
2008
38
Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer. (18692501)
2008
39
Extended hepatic resection for gallbladder cancer. (17693282)
2007
40
Predisposed to toxins: association of gallbladder cancer with N-acetyl transferase SNPs. (17297302)
2007
41
Expression of p21 and p27 in gallbladder cancer. (17457432)
2007
42
CA 125: a potential tumor marker for gallbladder cancer. (16724349)
2006
43
Preliminary study of p53 and c-erbB-2 expression in gallbladder cancer in Indian patients manuscript id: 8962091628764582. (16686942)
2006
44
Preneoplastic lesions in gallbladder cancer. (16724345)
2006
45
Gallbladder cancer in India: a dismal picture. (15683437)
2005
46
Antineoplastic effects of octreotide on human gallbladder cancer cells in vitro. (15052690)
2004
47
Detection of bone marrow micrometastases in patients with gallbladder cancer]. (15743160)
2004
48
Gallbladder cancer: an 'Indian' disease. (14606770)
2003
49
Abnormal arrangement of the pancreato-biliary ductal system associated with advanced gallbladder cancer diagnosed 3 years after follow-up ultrasonography. (14673731)
2003
50
Genetic analysis of xanthogranulomatous cholecystitis: precancerous lesion of gallbladder cancer? (12143246)
2002

Variations for Gallbladder Cancer

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Expression for genes affiliated with Gallbladder Cancer

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Search GEO for disease gene expression data for Gallbladder Cancer.

Pathways for genes affiliated with Gallbladder Cancer

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Pathways related to Gallbladder Cancer according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7MUC2, TGFBR2
2
Show member pathways
9.6DPYD, TYMS
39.3TGFBR2, APC, MLH1
4
Show member pathways
Signal transduction PTEN pathway58
9.3TGFBR2, APC, MLH1
59.3TGFBR2, APC, MLH1
6
Show member pathways
9.2MLH1, TYMS, DPYD

Compounds for genes affiliated with Gallbladder Cancer

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Compounds related to Gallbladder Cancer according to GeneCards Suite gene sharing:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
15-fluorocytosine4310.1PSG2, TYMS
2iudr4310.1TYMS, MLH1
3pyrimidine analogues4910.0TYMS, DPYD
4tegafur-uracil4310.0TYMS, DPYD
5eniluracil4310.0TYMS, DPYD
62-deoxyuridine-5-monophosphate4310.0DPYD, TYMS
75-fluoro-2-deoxyuridine-5-monophosphate439.9TYMS, DPYD
8bvdu439.9TYMS, DPYD
9tegafur43 4910.9DPYD, TYMS
105-deoxy-5-fluorouridine439.8DPYD, TYMS
11tetrahydrofolate439.8TYMS, MLH1
12orotic acid43 24 1211.8DPYD, TYMS
13cytosine43 2410.7PSG2, APC, MLH1
14tomudex439.7TYMS, DPYD
15mononucleotide439.7TGFBR2, APC, MLH1
16fudr439.7TYMS, PSG2, DPYD
17idurd439.7MLH1, TYMS, DPYD
18deoxycholic acid43 28 24 1212.7CDX2, MUC2, CYP7A1
19sn 3843 5910.6MLH1, TYMS, DPYD
20leucovorin43 49 1211.6TYMS, PSG2, DPYD
21sodium bisulfite439.6MLH1, APC
22azathioprine43 2 49 1212.6MLH1, MUC2, DPYD
23oxaliplatin43 49 1211.6DPYD, TYMS, MLH1
24sulfate43 2410.6HPSE, CCKAR, MUC2
25capecitabine43 49 1211.6TYMS, DPYD
26thiopurine439.6DPYD, TYMS
27irinotecan43 49 1211.6MLH1, TYMS, DPYD
28agarose439.5HPSE, MUC2, TGFBR2, MLH1
29thymidylate439.5DPYD, TYMS, MLH1
30camptothecin43 59 1211.4MLH1, TYMS, DPYD
31adenine43 24 1211.4TGFBR2, APC, MLH1
32gemcitabine43 49 1211.4MLH1, TYMS, DPYD, HPSE
33folate439.2MLH1, TYMS, APC, DPYD
34fatty acid439.2MLH1, APC, CCKAR, CDX2
35methionine439.1MLH1, APC, TGFBR2, CCKAR
365fluorouracil439.1DPYD, PSG2, MUC2, TYMS, MLH1
37thymidine43 2410.0MLH1, TYMS, PSG2, DPYD, CDX2
38crcs438.9MLH1, APC, TGFBR2, MUC2, DPYD
39cysteine438.8TYMS, TGFBR2, MUC2, DPYD, CDX2
40paraffin438.7MLH1, APC, MUC2, PSG2, DPYD, CDX2
41oligonucleotide438.7APC, TGFBR2, MUC2, DPYD, HPSE, CDX2
42retinoic acid43 249.6MLH1, CYP7A1, APC, TGFBR2, MUC2
43vegf438.6MLH1, TYMS, TGFBR2, PSG2, DPYD, HPSE
445-aza-2deoxycytidine438.3CDX2, HPSE, DPYD, MUC2, TGFBR2, APC
45calcium43 49 24 1211.3MLH1, APC, TGFBR2, MUC2, CCKAR, HPSE
46lipid438.0HPSE, CCKAR, PSG2, APC, CYP7A1
47glucose438.0CYP7A1, APC, TGFBR2, MUC2, PSG2, CCKAR
48progesterone43 28 59 24 1212.0MLH1, CYP7A1, APC, TGFBR2, MUC2, DPYD
49estrogen437.7MLH1, CYP7A1, APC, TGFBR2, MUC2, DPYD
50tyrosine436.9MLH1, CYP7A1, APC, TGFBR2, CCKAR, DPYD

GO Terms for genes affiliated with Gallbladder Cancer

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Biological processes related to Gallbladder Cancer according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1somatic stem cell maintenanceGO:00350199.7APC, CDX2
2pyrimidine nucleobase metabolic processGO:00062069.6DPYD, TYMS
3organ regenerationGO:00311009.6TGFBR2, TYMS
4blood vessel developmentGO:00015689.4CDX2, TGFBR2
5embryo implantationGO:00075669.2TRO, TGFBR2

Products for genes affiliated with Gallbladder Cancer

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Sources for Gallbladder Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet