GBC
MCID: GLL018
MIFTS: 67

Gallbladder Cancer (GBC) malady

Rare diseases, Cancer diseases, Liver diseases, Nephrological diseases, Gastrointestinal diseases categories
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Summaries for Gallbladder Cancer

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MedlinePlus:33 Your gallbladder is a pear-shaped organ under your liver. it stores bile, a fluid made by your liver to digest fat. as your stomach and intestines digest food, your gallbladder releases bile through a tube called the common bile duct. the duct connects your gallbladder and liver to your small intestine. cancer of the gallbladder is rare. it is more common in women and native americans. symptoms include jaundice (yellowing of the skin and whites of the eyes) pain above the stomach fever nausea and vomiting bloating lumps in the abdomen it is hard to diagnose gallbladder cancer in its early stages. sometimes doctors find it when they remove the gallbladder for another reason. but people with gallstones rarely have gallbladder cancer. because it is often found late, it can be hard to treat gallbladder cancer. treatment options include surgery, chemotherapy, radiation, or a combination. nih: national cancer institute

MalaCards based summary: Gallbladder Cancer, also known as gallbladder carcinoma, is related to cholangiocarcinoma and gallbladder disease, and has symptoms including extrahepatic biliary tract/gallbladder neoplasm/tumor/carcinoma/cancer, acute abdominal pain/colic and anorexia. An important gene associated with Gallbladder Cancer is HPSE (heparanase), and among its related pathways are NTHi-Induced Signaling and Pyrimidine metabolism. The compounds 5-fluorocytosine and iudr have been mentioned in the context of this disorder. Affiliated tissues include the gallbladder, liver and lymph node, and related mouse phenotypes are tumorigenesis and endocrine/exocrine gland.

Disease Ontology:8 A biliary tract cancer that is located in the gallbladder.

Wikipedia:65 Gallbladder cancer is a relatively uncommon cancer. It has peculiar geographical distribution being... more...

Aliases & Classifications for Gallbladder Cancer

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 33MedlinePlus, 62UMLS, 34MeSH, 57SNOMED-CT, 39NCIt, 63UMLS via Orphanet, 26ICD10 via Orphanet, 25ICD10
See all sources

Gallbladder Cancer, Aliases & Descriptions:

Name: Gallbladder Cancer 8 10 44 48 33
Gallbladder Carcinoma 8 10 44 62
Malignant Tumor of the Gallbladder 8 62
Malignant Neoplasm of Gallbladder 8 62
Carcinoma of the Gallbladder 48 62
Cancer of the Gallbladder 8 62
Tumor of the Gallbladder 8 62
Carcinoma of Gallbladder 8 62
 
Gallbladder Neoplasm 8 62
Malignant Neoplasm of Gallbladder Localized 62
Localized Malignant Gallbladder Neoplasm 8
Malignant Tumour of Gallbladder 8
Carcinoma Gallbladder 8
Gall Bladder Cancer 42
Gallbladder Ca 8
Gbc 48


Classifications:



Characteristics (Orphanet epidemiological data):

48
gallbladder cancer:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Adulthood


External Ids:

Disease Ontology8 DOID:3121, DOID:4948
MeSH34 D005706
NCIt39 C3048, C3844
UMLS via Orphanet63 C0235782
ICD10 via Orphanet26 C23
ICD1025 C23

Related Diseases for Gallbladder Cancer

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Diseases related to Gallbladder Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 149)
idRelated DiseaseScoreTop Affiliating Genes
1cholangiocarcinoma31.1PSG2, CDX2, MUC2
2gallbladder disease30.8MUC2, CCKAR
3ulcerative colitis30.4APC, MLH1, MUC2
4cholelithiasis30.2CYP7A1, PSG2
5lung cancer30.0TYMS, CDX2, TGFBR2, PSG2
6retinoblastoma29.9TYMS, TGFBR2, APC
7melanoma29.7CDX2, HPSE, MLH1, PSG2
8adenoma29.6MUC2, MLH1, APC, TGFBR2, PSG2, CDX2
9liver cancer29.5PSG2, HPSE, MUC2, TGFBR2, APC, DPYD
10breast cancer29.5CDX2, TYMS, TGFBR2, PSG2, DPYD, HPSE
11adenocarcinoma28.7CDX2, MLH1, HPSE, DPYD, CCKAR, PSG2
12cholecystitis10.7
13adenosquamous carcinoma10.6
14spindle cell carcinoma10.6
15xanthogranulomatous cholecystitis10.6
16ampulla of vater carcinoma10.5MUC2
17large cell neuroendocrine carcinoma10.5
18hepatitis10.5
19adult acute lymphocytic leukemia10.5TYMS
20pseudomyxoma peritonei10.4MUC2, CDX2
215-fluorouracil toxicity10.4DPYD
22pleomorphic carcinoma10.4
23bronchiolo-alveolar adenocarcinoma10.3CDX2, MUC2
24intestinal neoplasm10.3CDX2, APC
25gastritis10.3MLH1, CDX2
26tubular adenocarcinoma10.3MUC2, CDX2
27endotheliitis10.3
28turcot syndrome10.3MLH1, APC
29gallbladder signet ring cell adenocarcinoma10.3
30familial colorectal cancer10.3MLH1, APC
31von hippel-lindau disease10.3
32gastrointestinal stromal tumor10.3
33neuroendocrine tumor10.3
34pancreatitis10.3
35endometrial carcinoma10.3MLH1, CDX2
36laryngeal benign neoplasm10.3MUC2, PSG2
37adenosquamous gallbladder carcinoma10.2
38rectal neoplasm10.2TYMS, DPYD
39pancreas disease10.2CCKAR, PSG2
40gastrointestinal system disease10.2CCKAR, PSG2
41factor vii deficiency10.2PSG2, TYMS
42barrett's esophagus10.2CDX2, APC, MUC2
43gallbladder endocrine tumor10.2
44duodenitis10.2
45bacteremia10.2
46bladder carcinoma10.2PSG2, MUC2, TYMS
47mucoepidermoid carcinoma10.2TGFBR2, PSG2, MUC2
48stomatitis10.2TYMS, DPYD
49gallbladder small cell carcinoma10.2
50hypoxia10.2

Graphical network of the top 20 diseases related to Gallbladder Cancer:



Diseases related to gallbladder cancer

Symptoms for Gallbladder Cancer

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Symptoms:

48
  • extrahepatic biliary tract/gallbladder neoplasm/tumor/carcinoma/cancer
  • acute abdominal pain/colic
  • anorexia
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • hepatitis/icterus/cholestasis
  • lymphadenopathy/polyadenopathies

HPO human phenotypes related to Gallbladder Cancer:

id Description Frequency HPO Source Accession
1 biliary tract neoplasm hallmark (90%) HP:0100574
2 abdominal pain typical (50%) HP:0002027
3 anorexia typical (50%) HP:0002039
4 nausea and vomiting occasional (7.5%) HP:0002017
5 lymphadenopathy occasional (7.5%) HP:0002716

Drugs & Therapeutics for Gallbladder Cancer

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Drug clinical trials:

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Search NIH Clinical Center for Gallbladder Cancer

Genetic Tests for Gallbladder Cancer

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Anatomical Context for Gallbladder Cancer

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MalaCards organs/tissues related to Gallbladder Cancer:

32
Liver, Lymph node, Eye, Skin, Small intestine, Endothelial, Pancreas, Testes, Bone marrow, Bone, Colon, Lung, Thyroid, Prostate

FMA organs/tissues related to Gallbladder Cancer:

14
The gallbladder

Animal Models for Gallbladder Cancer or affiliated genes

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MGI Mouse Phenotypes related to Gallbladder Cancer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7MLH1, APC, TGFBR2, MUC2, CDX2
2MP:00053798.0MLH1, APC, TGFBR2, MUC2, CCKAR, HPSE
3MP:00053787.9CDX2, CCKAR, MUC2, TGFBR2, APC, CYP7A1
4MP:00053847.9MLH1, APC, TGFBR2, MUC2, CCKAR, CDX2
5MP:00053817.7CDX2, MLH1, CYP7A1, APC, TGFBR2, MUC2
6MP:00053767.5MLH1, CYP7A1, APC, TGFBR2, MUC2, CCKAR
7MP:00107687.1MLH1, CYP7A1, APC, TGFBR2, MUC2, CDX2

Publications for Gallbladder Cancer

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Articles related to Gallbladder Cancer:

(show top 50)    (show all 543)
idTitleAuthorsYear
1
Curative resection of gallbladder cancer with liver invasion and hepatic metastasis after chemotherapy with gemcitabine plus S-1: report of a case. (25367161)
2014
2
Gallbladder cancer. (25392833)
2014
3
Risk factors of lymphatic metastasis complement poor radiological detection in gallbladder cancer. (24415884)
2014
4
Simultaneous occurrence of gallbladder cancer in a laundry couple: association between gallbladder cancer and benzene. (23458990)
2013
5
Unsuspected gallbladder cancer: a clinical retrospective study. (24206403)
2013
6
Gallbladder wall calcification and gallbladder cancer. (23683783)
2013
7
Recent advances in systemic therapies and radiotherapy for gallbladder cancer. (23290830)
2013
8
Role of routine 16b1 lymph node biopsy in the management of gallbladder cancer: an analysis. (23869478)
2013
9
Prognostic significance of nemo-like kinase (NLK) expression in patients with gallbladder cancer. (23857283)
2013
10
Risk factors for gallbladder cancer: a case-control study. (22890893)
2013
11
Letter Re: Gallbladder cancer involving the extrahepatic bile duct is worthy of resection. (23728286)
2013
12
Gallbladder cancer in the Netherlands: incidence, treatment and survival patterns since 1989. (22441693)
2012
13
Gallbladder cancer, a vanishing disease? (22926299)
2012
14
Significant role of estrogen and progesterone receptor sequence variants in gallbladder cancer predisposition: a multi-analytical strategy. (22808109)
2012
15
Analysis of the relationships between clinicopathologic factors and survival in gallbladder cancer following surgical resection with curative intent. (23300551)
2012
16
Incidental gallbladder cancer diagnosed during or after laparoscopic cholecystectomy in members of the Turkish population with gallstone disease. (22234759)
2011
17
Risk factors of gallbladder cancer in Karachi-a case-control study. (22151791)
2011
18
Development of a questionnaire (EORTC module) to measure quality of life in patients with cholangiocarcinoma and gallbladder cancer, the EORTC QLQ-BIL21. (21266979)
2011
19
A phase II trial of gemcitabine and capecitabine in patients with unresectable or metastatic gallbladder cancer or cholangiocarcinoma: Southwest Oncology Group study S0202. (21556747)
2011
20
Outcome of adjuvant therapy for gallbladder cancer. (21212704)
2010
21
Comparative analysis between clinical outcomes of primary radical resection and second completion radical resection for T2 gallbladder cancer: single-center experience. (20333380)
2010
22
Iodine-125 biliary stent for palliative treatment of locally advanced gallbladder cancer. (20931472)
2010
23
Metastatic gallbladder cancer presenting as a gingival tumor and deep neck infection. (20950782)
2010
24
Does gallbladder cancer divide India? (20373078)
2010
25
Segmental hepatic resection (segments IVb-V) with lymph node dissection for gallbladder cancer. (20595073)
2010
26
Comment on: Lifestyle, reproductive factors and risk of gallbladder cancer. (19960170)
2009
27
Evolving treatment strategies for gallbladder cancer. (19495882)
2009
28
Complement receptor 1 (A3650G RsaI and intron 27 HindIII) polymorphisms and risk of gallbladder cancer in north Indian population. (19906204)
2009
29
Gallbladder cancer. (18466866)
2008
30
Lifestyle, reproductive factors and risk of gallbladder cancer. (19037558)
2008
31
Prognostic factors for gallbladder cancer in Japan. (18948808)
2008
32
Treatment considerations for gallbladder cancer should include extent of surgery. (18802170)
2008
33
Gallbladder cancer and radical surgery. (18791371)
2008
34
Survival prediction models for estimating the benefit of post-operative radiation therapy for gallbladder cancer and lung cancer. (18999217)
2008
35
IL-1 gene polymorphisms and genetic susceptibility of gallbladder cancer in a north Indian population. (18940468)
2008
36
Gallbladder cancer: the basics. (21960896)
2008
37
Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer. (18692501)
2008
38
Extended hepatic resection for gallbladder cancer. (17693282)
2007
39
Predisposed to toxins: association of gallbladder cancer with N-acetyl transferase SNPs. (17297302)
2007
40
Expression of p21 and p27 in gallbladder cancer. (17457432)
2007
41
CA 125: a potential tumor marker for gallbladder cancer. (16724349)
2006
42
Preliminary study of p53 and c-erbB-2 expression in gallbladder cancer in Indian patients manuscript id: 8962091628764582. (16686942)
2006
43
Preneoplastic lesions in gallbladder cancer. (16724345)
2006
44
Gallbladder cancer in India: a dismal picture. (15683437)
2005
45
Antineoplastic effects of octreotide on human gallbladder cancer cells in vitro. (15052690)
2004
46
Detection of bone marrow micrometastases in patients with gallbladder cancer]. (15743160)
2004
47
Gallbladder cancer: an 'Indian' disease. (14606770)
2003
48
Immunohistochemical analysis of transforming growth factor beta in gallbladder cancer. (12579267)
2003
49
Abnormal arrangement of the pancreato-biliary ductal system associated with advanced gallbladder cancer diagnosed 3 years after follow-up ultrasonography. (14673731)
2003
50
Genetic analysis of xanthogranulomatous cholecystitis: precancerous lesion of gallbladder cancer? (12143246)
2002

Variations for Gallbladder Cancer

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Expression for genes affiliated with Gallbladder Cancer

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Expression patterns in normal tissues for genes affiliated with Gallbladder Cancer

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Pathways for genes affiliated with Gallbladder Cancer

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Pathways related to Gallbladder Cancer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7MUC2, TGFBR2
2
Show member pathways
9.6DPYD, TYMS
39.3TGFBR2, APC, MLH1
4
Show member pathways
Signal transduction PTEN pathway60
9.3TGFBR2, APC, MLH1
59.3TGFBR2, APC, MLH1
6
Show member pathways
9.2MLH1, TYMS, DPYD

Compounds for genes affiliated with Gallbladder Cancer

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Compounds related to Gallbladder Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
15-fluorocytosine4410.1PSG2, TYMS
2iudr4410.1MLH1, TYMS
3pyrimidine analogues5010.0DPYD, TYMS
4tegafur-uracil4410.0TYMS, DPYD
5eniluracil4410.0DPYD, TYMS
62-deoxyuridine-5-monophosphate4410.0DPYD, TYMS
7bvdu449.9TYMS, DPYD
85-fluoro-2-deoxyuridine-5-monophosphate449.9DPYD, TYMS
9tegafur44 5010.9DPYD, TYMS
105-deoxy-5-fluorouridine449.8DPYD, TYMS
11tetrahydrofolate449.8MLH1, TYMS
12orotic acid44 24 1111.8TYMS, DPYD
13sodium bisulfite449.7MLH1, APC
14cytosine44 2410.7MLH1, PSG2, APC
15tomudex449.7DPYD, TYMS
16mononucleotide449.7TGFBR2, MLH1, APC
17fudr449.7TYMS, PSG2, DPYD
18idurd449.7DPYD, TYMS, MLH1
19deoxycholic acid44 28 24 1112.7MUC2, CDX2, CYP7A1
20sn 3844 6110.6DPYD, TYMS, MLH1
21leucovorin44 50 1111.6TYMS, PSG2, DPYD
22azathioprine44 2 50 1112.6DPYD, MUC2, MLH1
23oxaliplatin44 50 1111.6MLH1, DPYD, TYMS
24sulfate44 2410.6HPSE, CCKAR, MUC2
25thiopurine449.6DPYD, TYMS
26irinotecan44 50 1111.6TYMS, MLH1, DPYD
27agarose449.5TGFBR2, HPSE, MUC2, MLH1
28thymidylate449.5TYMS, MLH1, DPYD
29capecitabine44 50 1111.5DPYD, TYMS
30camptothecin44 61 1111.4TYMS, DPYD, MLH1
31adenine44 24 1111.4TGFBR2, APC, MLH1
32gemcitabine44 50 1111.4HPSE, DPYD, TYMS, MLH1
33folate449.2APC, DPYD, TYMS, MLH1
34fatty acid449.2APC, CCKAR, MLH1, CDX2
35methionine449.1CCKAR, TGFBR2, APC, MLH1
365fluorouracil449.1TYMS, DPYD, PSG2, MUC2, MLH1
37thymidine44 2410.0CDX2, MLH1, TYMS, PSG2, DPYD
38crcs448.9MLH1, APC, TGFBR2, MUC2, DPYD
39cysteine448.8TYMS, TGFBR2, MUC2, DPYD, CDX2
40paraffin448.7DPYD, MUC2, APC, MLH1, CDX2, PSG2
41oligonucleotide448.7MUC2, APC, TGFBR2, DPYD, CDX2, HPSE
42retinoic acid44 249.6MLH1, CYP7A1, APC, TGFBR2, MUC2
43vegf448.6DPYD, MLH1, TGFBR2, HPSE, TYMS, PSG2
445-aza-2deoxycytidine448.3CDX2, MLH1, APC, TGFBR2, DPYD, HPSE
45calcium44 50 24 1111.3APC, MLH1, TGFBR2, MUC2, CCKAR, CDX2
46lipid448.0CYP7A1, APC, PSG2, CCKAR, HPSE
47glucose448.0APC, CCKAR, PSG2, HPSE, CYP7A1, TGFBR2
48progesterone44 28 61 24 1112.0CDX2, TGFBR2, DPYD, APC, CYP7A1, MLH1
49estrogen447.7CDX2, HPSE, DPYD, MUC2, TGFBR2, APC
50tyrosine446.9CYP7A1, DPYD, APC, TRO, CDX2, CCKAR

GO Terms for genes affiliated with Gallbladder Cancer

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Biological processes related to Gallbladder Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1somatic stem cell maintenanceGO:0350199.7APC, CDX2
2pyrimidine nucleobase metabolic processGO:0062069.6DPYD, TYMS
3organ regenerationGO:0311009.6TGFBR2, TYMS
4blood vessel developmentGO:0015689.4CDX2, TGFBR2
5embryo implantationGO:0075669.2TRO, TGFBR2

Products for genes affiliated with Gallbladder Cancer

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  • Antibodies
  • Proteins
  • Lysates

Sources for Gallbladder Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet