GBC
MCID: GLL018
MIFTS: 66

Gallbladder Cancer (GBC) malady

Rare diseases, Cancer diseases, Liver diseases, Nephrological diseases, Gastrointestinal diseases categories

Summaries for Gallbladder Cancer

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Sources:
9Disease Ontology, 35MedlinePlus, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Your gallbladder is a pear-shaped organ under your liver. it stores bile, a fluid made by your liver to digest fat. as your stomach and intestines digest food, your gallbladder releases bile through a tube called the common bile duct. the duct connects your gallbladder and liver to your small intestine. cancer of the gallbladder is rare. it is more common in women and native americans. symptoms include jaundice (yellowing of the skin and whites of the eyes) pain above the stomach fever nausea and vomiting bloating lumps in the abdomen it is hard to diagnose gallbladder cancer in its early stages. sometimes doctors find it when they remove the gallbladder for another reason. but people with gallstones rarely have gallbladder cancer. because it is often found late, it can be hard to treat gallbladder cancer. treatment options include surgery, chemotherapy, radiation, or a combination. nih: national cancer institute

MalaCards: Gallbladder Cancer, also known as gallbladder carcinoma, is related to cholangiocarcinoma and gallbladder disease, and has symptoms including acute abdominal pain/colic, anorexia and nausea/vomiting/regurgitation/merycism/hyperemesis. An important gene associated with Gallbladder Cancer is HPSE (heparanase), and among its related pathways are NTHi-Induced Signaling and Pyrimidine metabolism. The compounds 5-fluorocytosine and iudr have been mentioned in the context of this disorder. Affiliated tissues include the gallbladder, liver and lymph node, and related mouse phenotypes are tumorigenesis and endocrine/exocrine gland.

Disease Ontology:9 A biliary tract cancer that is located in the gallbladder.

Wikipedia:66 Gallbladder cancer is a relatively uncommon cancer. It has peculiar geographical distribution being... more...

Aliases & Classifications for Gallbladder Cancer

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 50Orphanet, 35MedlinePlus, 63UMLS, 36MeSH, 59SNOMED-CT, 41NCIt, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 26ICD10
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Classifications:



Characteristics (Orphanet epidemiological data):

50
gallbladder cancer:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Adulthood


Aliases & Descriptions:

gallbladder cancer 9 11 46 50 35
gallbladder carcinoma 9 11 46 63
malignant neoplasm of gallbladder 9 63
gallbladder neoplasm 9 63
malignant neoplasm of gallbladder localized 63
localized malignant gallbladder neoplasm 9
malignant tumor of the gallbladder 9
malignant tumour of gallbladder 9
carcinoma of the gallbladder 50
cancer of the gallbladder 9
tumor of the gallbladder 9
carcinoma of gallbladder 9
carcinoma gallbladder 9
gall bladder cancer 44
gallbladder ca 9
gbc 50


External Ids:

Disease Ontology9 DOID:3121, DOID:4948
MeSH36 D005706
NCIt41 C3048, C3844
ICD10 via Orphanet27 C23
SNOMED-CT via Orphanet60 372140005
UMLS via Orphanet64 C0235782
ICD1026 C23

Related Diseases for Gallbladder Cancer

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Gallbladder Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 140)
idRelated DiseaseScoreTop Affiliating Genes
1cholangiocarcinoma30.8CDX2, PSG2, MUC2
2gallbladder disease30.4MUC2, CCKAR
3ulcerative colitis30.2MUC2, APC, MLH1
4cholelithiasis30.0PSG2, CYP7A1
5retinoblastoma30.0TGFBR2, APC, TYMS
6lung cancer29.9TYMS, TGFBR2, PSG2, CDX2
7melanoma29.9CDX2, HPSE, PSG2, MLH1
8adenoma29.8MLH1, APC, TGFBR2, MUC2, PSG2, CDX2
9hepatocellular carcinoma29.8APC, TGFBR2, MUC2, PSG2, DPYD, HPSE
10adenocarcinoma29.8MLH1, TYMS, CDX2, HPSE, DPYD, CCKAR
11colon cancer29.7DPYD, PSG2, MUC2, TGFBR2, APC, TYMS
12neuroendocrine carcinoma10.7
13cholecystitis10.6
14adenosquamous carcinoma10.6
15spindle cell carcinoma10.6
16xanthogranulomatous cholecystitis10.5
17large cell neuroendocrine carcinoma10.5
18hepatitis10.4
19pleomorphic carcinoma10.4
20endotheliitis10.3
21gastrointestinal stromal tumor10.3
22von hippel-lindau disease10.3
23neuroendocrine tumor10.3
24pancreatitis10.3
25duodenitis10.2
26gallbladder endocrine tumor10.2
27bacteremia10.2
28gallbladder small cell carcinoma10.1
29adenosquamous gallbladder carcinoma10.1
30hypoxia10.1
31ileus10.1
32acute pancreatitis10.1
33bullous pemphigoid10.1
34necrotizing fasciitis10.1
35biliary dyskinesia10.1
36clonorchiasis10.1
37papillary carcinoma10.1
38gallbladder signet ring cell adenocarcinoma10.1
39cushing's syndrome10.1
40cribriform carcinoma10.1
41cervicitis10.1
42fasciitis10.1
43in situ carcinoma10.1
44neuropathy10.1
45sarcoma10.1
46primary sclerosing cholangitis10.1
47granular cell tumor10.1
48keratinizing squamous cell carcinoma10.1
49adenocarcinoma in situ10.1
50malignant peripheral nerve sheath tumor10.1

Graphical network of the top 20 diseases related to Gallbladder Cancer:



Diseases related to gallbladder cancer

Symptoms for Gallbladder Cancer

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Sources:
50Orphanet
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Symptoms:

50
  • acute abdominal pain/colic
  • anorexia
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • hepatitis/icterus/cholestasis
  • lymphadenopathy/polyadenopathies
  • extrahepatic biliary tract/gallbladder neoplasm/tumor/carcinoma/cancer

Drugs & Therapeutics for Gallbladder Cancer

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Gallbladder Cancer

Drug clinical trials:

Search ClinicalTrials for Gallbladder Cancer

Search NIH Clinical Center for Gallbladder Cancer

Search CenterWatch for Gallbladder Cancer

Genetic Tests for Gallbladder Cancer

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Anatomical Context for Gallbladder Cancer

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34MalaCards, 15FMA
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MalaCards organs/tissues related to Gallbladder Cancer:

34
Liver, Lymph node, Skin, Eye, Small intestine, Endothelial, Pancreas, Testes, Lung, Bone marrow, Bone, Prostate, Colon, Thyroid

FMA organs/tissues related to Gallbladder Cancer:

15
The gallbladder

Animal Models for Gallbladder Cancer or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Gallbladder Cancer:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7MLH1, APC, TGFBR2, MUC2, CDX2
2MP:00053798.0MLH1, APC, TGFBR2, MUC2, CCKAR, HPSE
3MP:00053787.9CDX2, CCKAR, MUC2, TGFBR2, APC, CYP7A1
4MP:00053847.9MLH1, APC, TGFBR2, MUC2, CCKAR, CDX2
5MP:00053817.7CDX2, MLH1, CYP7A1, APC, TGFBR2, MUC2
6MP:00053767.5MLH1, CYP7A1, APC, TGFBR2, MUC2, CCKAR
7MP:00107687.1MLH1, CYP7A1, APC, TGFBR2, MUC2, CDX2

Publications for Gallbladder Cancer

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Sources:
53PubMed
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Articles related to Gallbladder Cancer:

(show top 50)    (show all 520)
idTitleAuthorsYear
1
Risk factors of lymphatic metastasis complement poor radiological detection in gallbladder cancer. (24415884)
2014
2
Simultaneous occurrence of gallbladder cancer in a laundry couple: association between gallbladder cancer and benzene. (23458990)
2013
3
Unsuspected gallbladder cancer: a clinical retrospective study. (24206403)
2013
4
Gallbladder wall calcification and gallbladder cancer. (23683783)
2013
5
Recent advances in systemic therapies and radiotherapy for gallbladder cancer. (23290830)
2013
6
Role of routine 16b1 lymph node biopsy in the management of gallbladder cancer: an analysis. (23869478)
2013
7
Prognostic significance of nemo-like kinase (NLK) expression in patients with gallbladder cancer. (23857283)
2013
8
Risk factors for gallbladder cancer: a case-control study. (22890893)
2013
9
Letter Re: Gallbladder cancer involving the extrahepatic bile duct is worthy of resection. (23728286)
2013
10
Gallbladder cancer in the Netherlands: incidence, treatment and survival patterns since 1989. (22441693)
2012
11
Gallbladder cancer, a vanishing disease? (22926299)
2012
12
Significant role of estrogen and progesterone receptor sequence variants in gallbladder cancer predisposition: a multi-analytical strategy. (22808109)
2012
13
Analysis of the relationships between clinicopathologic factors and survival in gallbladder cancer following surgical resection with curative intent. (23300551)
2012
14
Assessment of lymph node status in gallbladder cancer: location, number, or ratio of positive nodes. (22594526)
2012
15
Incidental gallbladder cancer diagnosed during or after laparoscopic cholecystectomy in members of the Turkish population with gallstone disease. (22234759)
2011
16
Risk factors of gallbladder cancer in Karachi-a case-control study. (22151791)
2011
17
Development of a questionnaire (EORTC module) to measure quality of life in patients with cholangiocarcinoma and gallbladder cancer, the EORTC QLQ-BIL21. (21266979)
2011
18
A phase II trial of gemcitabine and capecitabine in patients with unresectable or metastatic gallbladder cancer or cholangiocarcinoma: Southwest Oncology Group study S0202. (21556747)
2011
19
Incidentally-discovered gallbladder cancer: When, why and which reoperation? (21478068)
2011
20
Outcome of adjuvant therapy for gallbladder cancer. (21212704)
2010
21
Comparative analysis between clinical outcomes of primary radical resection and second completion radical resection for T2 gallbladder cancer: single-center experience. (20333380)
2010
22
Iodine-125 biliary stent for palliative treatment of locally advanced gallbladder cancer. (20931472)
2010
23
Metastatic gallbladder cancer presenting as a gingival tumor and deep neck infection. (20950782)
2010
24
Does gallbladder cancer divide India? (20373078)
2010
25
Segmental hepatic resection (segments IVb-V) with lymph node dissection for gallbladder cancer. (20595073)
2010
26
Comment on: Lifestyle, reproductive factors and risk of gallbladder cancer. (19960170)
2009
27
Evolving treatment strategies for gallbladder cancer. (19495882)
2009
28
Complement receptor 1 (A3650G RsaI and intron 27 HindIII) polymorphisms and risk of gallbladder cancer in north Indian population. (19906204)
2009
29
Gallbladder cancer. (18466866)
2008
30
Lifestyle, reproductive factors and risk of gallbladder cancer. (19037558)
2008
31
Prognostic factors for gallbladder cancer in Japan. (18948808)
2008
32
Treatment considerations for gallbladder cancer should include extent of surgery. (18802170)
2008
33
Gallbladder cancer and radical surgery. (18791371)
2008
34
Survival prediction models for estimating the benefit of post-operative radiation therapy for gallbladder cancer and lung cancer. (18999217)
2008
35
IL-1 gene polymorphisms and genetic susceptibility of gallbladder cancer in a north Indian population. (18940468)
2008
36
Gallbladder cancer: the basics. (21960896)
2008
37
Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer. (18692501)
2008
38
Extended hepatic resection for gallbladder cancer. (17693282)
2007
39
Predisposed to toxins: association of gallbladder cancer with N-acetyl transferase SNPs. (17297302)
2007
40
Expression of p21 and p27 in gallbladder cancer. (17457432)
2007
41
CA 125: a potential tumor marker for gallbladder cancer. (16724349)
2006
42
Preliminary study of p53 and c-erbB-2 expression in gallbladder cancer in Indian patients manuscript id: 8962091628764582. (16686942)
2006
43
Preneoplastic lesions in gallbladder cancer. (16724345)
2006
44
Gallbladder cancer in India: a dismal picture. (15683437)
2005
45
Antineoplastic effects of octreotide on human gallbladder cancer cells in vitro. (15052690)
2004
46
Detection of bone marrow micrometastases in patients with gallbladder cancer]. (15743160)
2004
47
Gallbladder cancer: an 'Indian' disease. (14606770)
2003
48
Immunohistochemical analysis of transforming growth factor beta in gallbladder cancer. (12579267)
2003
49
Abnormal arrangement of the pancreato-biliary ductal system associated with advanced gallbladder cancer diagnosed 3 years after follow-up ultrasonography. (14673731)
2003
50
Genetic analysis of xanthogranulomatous cholecystitis: precancerous lesion of gallbladder cancer? (12143246)
2002

Variations for Gallbladder Cancer

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Expression for genes affiliated with Gallbladder Cancer

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gallbladder Cancer

Search GEO for disease gene expression data for Gallbladder Cancer.

Pathways for genes affiliated with Gallbladder Cancer

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Sources:
51PathCards, 54QIAGEN, 56Reactome, 39NCBI BioSystems Database, 52PharmGKB, 31KEGG, 61Thomson Reuters, 5Cell Signaling Technology
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Pathways related to Gallbladder Cancer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7MUC2, TGFBR2
2
Show member pathways
9.6DPYD, TYMS
39.3TGFBR2, APC, MLH1
4
Show member pathways
Signal transduction PTEN pathway61
9.3TGFBR2, APC, MLH1
59.3TGFBR2, APC, MLH1
6
Show member pathways
9.2MLH1, TYMS, DPYD

Compounds for genes affiliated with Gallbladder Cancer

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Sources:
46Novoseek, 52PharmGKB, 25HMDB, 12DrugBank, 30IUPHAR, 62Tocris Bioscience, 3BitterDB
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Compounds related to Gallbladder Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
15-fluorocytosine4610.1PSG2, TYMS
2iudr4610.1TYMS, MLH1
3pyrimidine analogues5210.0TYMS, DPYD
4tegafur-uracil4610.0TYMS, DPYD
5eniluracil4610.0TYMS, DPYD
62-deoxyuridine-5-monophosphate4610.0DPYD, TYMS
75-fluoro-2-deoxyuridine-5-monophosphate469.9TYMS, DPYD
8bvdu469.9TYMS, DPYD
9tegafur46 5210.9DPYD, TYMS
105-deoxy-5-fluorouridine469.8DPYD, TYMS
11tetrahydrofolate469.8TYMS, MLH1
12orotic acid46 25 1211.8DPYD, TYMS
13cytosine46 2510.7PSG2, APC, MLH1
14tomudex469.7TYMS, DPYD
15mononucleotide469.7TGFBR2, APC, MLH1
16fudr469.7TYMS, PSG2, DPYD
17idurd469.7MLH1, TYMS, DPYD
18deoxycholic acid46 30 25 1212.7CDX2, MUC2, CYP7A1
19sn 3846 6210.6MLH1, TYMS, DPYD
20leucovorin46 52 1211.6TYMS, PSG2, DPYD
21sodium bisulfite469.6MLH1, APC
22azathioprine46 3 52 1212.6MLH1, MUC2, DPYD
23oxaliplatin46 52 1211.6DPYD, TYMS, MLH1
24sulfate46 2510.6HPSE, CCKAR, MUC2
25capecitabine46 52 1211.6TYMS, DPYD
26thiopurine469.6DPYD, TYMS
27irinotecan46 52 1211.6MLH1, TYMS, DPYD
28agarose469.5HPSE, MUC2, TGFBR2, MLH1
29thymidylate469.5DPYD, TYMS, MLH1
30camptothecin46 62 1211.4MLH1, TYMS, DPYD
31adenine46 25 1211.4TGFBR2, APC, MLH1
32gemcitabine46 52 1211.4MLH1, TYMS, DPYD, HPSE
33folate469.2MLH1, TYMS, APC, DPYD
34fatty acid469.2MLH1, APC, CCKAR, CDX2
35methionine469.1MLH1, APC, TGFBR2, CCKAR
365fluorouracil469.1DPYD, PSG2, MUC2, TYMS, MLH1
37thymidine46 2510.0MLH1, TYMS, PSG2, DPYD, CDX2
38crcs468.9MLH1, APC, TGFBR2, MUC2, DPYD
39cysteine468.8TYMS, TGFBR2, MUC2, DPYD, CDX2
40paraffin468.7MLH1, APC, MUC2, PSG2, DPYD, CDX2
41oligonucleotide468.7APC, TGFBR2, MUC2, DPYD, HPSE, CDX2
42retinoic acid46 259.6MLH1, CYP7A1, APC, TGFBR2, MUC2
43vegf468.6MLH1, TYMS, TGFBR2, PSG2, DPYD, HPSE
445-aza-2deoxycytidine468.3CDX2, HPSE, DPYD, MUC2, TGFBR2, APC
45calcium46 52 25 1211.3MLH1, APC, TGFBR2, MUC2, CCKAR, HPSE
46lipid468.0HPSE, CCKAR, PSG2, APC, CYP7A1
47glucose468.0CYP7A1, APC, TGFBR2, MUC2, PSG2, CCKAR
48progesterone46 30 62 25 1212.0MLH1, CYP7A1, APC, TGFBR2, MUC2, DPYD
49estrogen467.7MLH1, CYP7A1, APC, TGFBR2, MUC2, DPYD
50tyrosine466.9MLH1, CYP7A1, APC, TGFBR2, CCKAR, DPYD

GO Terms for genes affiliated with Gallbladder Cancer

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17Gene Ontology
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Biological processes related to Gallbladder Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1somatic stem cell maintenanceGO:0350199.7APC, CDX2
2pyrimidine nucleobase metabolic processGO:0062069.6DPYD, TYMS
3organ regenerationGO:0311009.6TGFBR2, TYMS
4blood vessel developmentGO:0015689.4CDX2, TGFBR2
5embryo implantationGO:0075669.2TRO, TGFBR2

Products for genes affiliated with Gallbladder Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gallbladder Cancer

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet