GBC
MCID: GLL018
MIFTS: 64

Gallbladder Cancer (GBC) malady

Cancer diseases, Liver diseases, Nephrological diseases categories

Summaries for Gallbladder Cancer

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Sources:
8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Your gallbladder is a pear-shaped organ under your liver. it stores bile, a fluid made by your liver to digest fat. as your stomach and intestines digest food, your gallbladder releases bile through a tube called the common bile duct. the duct connects your gallbladder and liver to your small intestine. cancer of the gallbladder is rare. it is more common in women and native americans. symptoms include jaundice (yellowing of the skin and whites of the eyes) pain above the stomach fever nausea and vomiting bloating lumps in the abdomen it is hard to diagnose gallbladder cancer in its early stages. sometimes doctors find it when they remove the gallbladder for another reason. but people with gallstones rarely have gallbladder cancer. because it is often found late, it can be hard to treat gallbladder cancer. treatment options include surgery, chemotherapy, radiation, or a combination. nih: national cancer institute

MalaCards: Gallbladder Cancer, also known as gallbladder carcinoma, is related to gallbladder disease and cholangiocarcinoma, and has symptoms including extrahepatic biliary tract/gallbladder neoplasm/tumor/carcinoma/cancer, lymphadenopathy/polyadenopathies and anorexia. An important gene associated with Gallbladder Cancer is HPSE (heparanase). The compounds tyrosine and 5-aza-2deoxycytidine have been mentioned in the context of this disorder. Affiliated tissues include the gallbladder, liver and lymph node, and related mouse phenotypes are digestive/alimentary and endocrine/exocrine gland.

Disease Ontology:8 A biliary tract cancer that is located in the gallbladder.

Wikipedia:63 Gallbladder cancer is a relatively uncommon cancer. It has peculiar geographical distribution being... more...

Aliases & Classifications for Gallbladder Cancer

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 33MedlinePlus, 60UMLS, 42NIH Rare Diseases, 56SNOMED-CT, 39NCIt, 34MeSH, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Liver diseases, Nephrological diseases


Characteristics (Orphanet epidemiological data):

48
gallbladder cancer:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Adulthood


Aliases & Descriptions:

gallbladder cancer 8 10 44 48 33
gallbladder carcinoma 8 10 44 60
malignant neoplasm of gallbladder 8 60
gallbladder neoplasm 8 60
malignant neoplasm of gallbladder localized 60
localized malignant gallbladder neoplasm 8
malignant tumor of the gallbladder 8
malignant tumour of gallbladder 8
carcinoma of the gallbladder 48
cancer of the gallbladder 8
tumor of the gallbladder 8
carcinoma of gallbladder 8
carcinoma gallbladder 8
gall bladder cancer 42
gallbladder ca 8
gbc 48


External Ids:

Disease Ontology8 DOID:3121, DOID:4948
NCIt39 C3048, C3844
MeSH34 D005706
ICD10 via Orphanet26 C23
SNOMED-CT via Orphanet57 372140005
UMLS via Orphanet61 C0235782
ICD1025 C23

Related Diseases for Gallbladder Cancer

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17GeneCards, 18GeneDecks
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Diseases related to Gallbladder Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 171)
idRelated DiseaseScoreTop Affiliating Genes
1gallbladder disease30.8CCKAR, MUC2
2cholangiocarcinoma30.7PSG2, MUC2, CDX2, CEACAM3, CEACAM5
3hepatitis30.6CCL27
4pancreatic cancer30.3CCKAR, DPYD, MUC2, CDX2, IL32, SERPINB5
5pancreatitis30.3CCKAR
6neuroendocrine tumor30.3PSG2, CDX2, CEACAM3
7colorectal cancer30.1DPYD, TYMS, MUC2, CDX2, CYP7A1, HPSE
8adenocarcinoma30.1CCKAR, APC, PSG2, SNCG, MLH1, DPYD
9lung cancer30.1PSG2, TYMS, CDX2, CEACAM3, CEACAM5, TGFBR2
10sarcoma30.1SERPINB5, MLH1
11papillary carcinoma30.1MUC2, SERPINB5, CEACAM3
12squamous cell carcinoma30.1APC, PSG2, TGFBR2, MLH1, DPYD, TYMS
13hepatocellular carcinoma29.9MUC2, DPYD, PSG2, APC, CDX2, HPSE
14retinoblastoma29.9TGFBR2, TYMS, SNCG, APC
15colon cancer29.9TGFBR2, APC, PSG2, MLH1, DPYD, TYMS
16adenoma29.9APC, PSG2, MLH1, MUC2, CDX2, SERPINB5
17melanoma29.9PSG2, MLH1, CDX2, HPSE, SERPINB5, CEACAM3
18thyroid cancer29.9CCKAR, APC, SERPINB5
19cholelithiasis29.9CYP7A1, PSG2
20prostate cancer29.9TGFBR2, CEACAM3, SERPINB5, HPSE, CDX2
21neuroendocrine carcinoma10.6
22cholecystitis10.6
23spindle cell carcinoma10.6
24adenosquamous carcinoma10.6
25lymph node cancer10.5
26xanthogranulomatous cholecystitis10.5
27large cell carcinoma10.5
28pleomorphic carcinoma10.4
29vascular cancer10.3
30hepatitis a10.2
31connective tissue cancer10.2
32in situ carcinoma10.2
33gastrointestinal stromal tumor10.2
34von hippel-lindau disease10.2
35duodenitis10.2
36gall-bladder endocrine tumor10.2
37adenosquamous gallbladder carcinoma10.1
38abdominal aortic aneurysm10.1
39aortic aneurysm10.1
40gallbladder adenocarcinoma10.1
41obesity10.1
42tuberculosis10.1
43bullous pemphigoid10.1
44acute pancreatitis10.1
45gallbladder signet ring cell adenocarcinoma10.1
46cushing's syndrome10.1
47cribriform carcinoma10.1
48necrotizing fasciitis10.1
49spindle cell sarcoma10.1
50ulcerative colitis10.1

Graphical network of the top 20 diseases related to Gallbladder Cancer:



Diseases related to gallbladder cancer

Clinical Features for Gallbladder Cancer

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Sources:
48Orphanet
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Symptoms:

48
  • extrahepatic biliary tract/gallbladder neoplasm/tumor/carcinoma/cancer
  • lymphadenopathy/polyadenopathies
  • anorexia
  • acute abdominal pain/colic
  • hepatitis/icterus/cholestasis
  • nausea/vomiting/regurgitation/merycism/hyperemesis

Drugs & Therapeutics for Gallbladder Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Gallbladder Cancer

Drug clinical trials:

Search ClinicalTrials for Gallbladder Cancer

Search NIH Clinical Center for Gallbladder Cancer

Search CenterWatch for Gallbladder Cancer

Genetic Tests for Gallbladder Cancer

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Anatomical Context for Gallbladder Cancer

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Gallbladder Cancer:

32
Liver, Lymph node, Eye, Skin, Small intestine, Endothelial, Lung, Colon, Pancreas, Testes, Breast, Thyroid, Bone marrow, Prostate, Bone

FMA organs/tissues related to Gallbladder Cancer:

14
The gallbladder

Animal Models for Gallbladder Cancer or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Gallbladder Cancer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538110.6CCKAR, APC, MLH1, MUC2, CDX2, CYP7A1
2MP:000537910.3CCKAR, MLH1, MUC2, CDX2, HPSE, MST1R

Publications for Gallbladder Cancer

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Sources:
50PubMed
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Articles related to Gallbladder Cancer:

(show top 50)    (show all 541)
idTitleAuthorsYear
1
Downregulated expression of metastasis associated in colon cancer 1 (MACC1) reduces gallbladder cancer cell proliferation and invasion. (24425103)
2014
2
Inhibition of SCAMP1 suppresses cell migration and invasion in human pancreatic and gallbladder cancer cells. (23653380)
2013
3
Differentiation of adenomyomatosis of the gallbladder from early-stage, wall-thickening-type gallbladder cancer using high-resolution ultrasound. (23247807)
2013
4
Adjuvant chemoradiation for resected gallbladder cancer: Treatment strategies for one of the leading causes of cancer death in Chilean women. (24061456)
2013
5
Actual status of clinical diagnosis in patients with primary gallbladder cancer associated with adenomyomatosis. (24214664)
2013
6
Letter to the editor regarding manuscript entitled: T-category reflects the histopathologic characteristics of gallbladder cancer. (23084089)
2013
7
Surgical strategy for T2 and T3 gallbladder cancer: is extrahepatic bile duct resection always necessary? (24057276)
2013
8
Somatostatin receptors 3, 4 and 5 play important roles in gallbladder cancer. (23991955)
2013
9
Prognostic significance of K-ras codon 12 mutation in patients with resected gallbladder cancer. (23838952)
2013
10
Gallbladder metastasis secondary to gastric cancer as a first site of recurrence presented with acute cholecystitis: case report and literature review. (23864451)
2012
11
Gallbladder cancer: a subtype of biliary tract cancer which is a current challenge in China. (22799325)
2012
12
Outcomes and prognostic factors in gallbladder cancer: a single-centre experience. (22454256)
2012
13
DNA promoter methylation as a diagnostic and therapeutic biomarker in gallbladder cancer. (22794276)
2012
14
The improvement of surgical treatment for patients with gallbladder cancer: analysis of 208 consecutive cases over the past decade. (23065499)
2012
15
Fourteen year surgical experience of gallbladder cancer: validity of curative resection affecting survival. (22251521)
2012
16
Chronic heavy metal exposure and gallbladder cancer risk in India, a comparative study with Japan. (22502665)
2012
17
Choledochoduodenal fistula presenting with pneumobilia in a patient with gallbladder cancer: a case report. (22333461)
2012
18
Propofol induces proliferation and invasion of gallbladder cancer cells through activation of Nrf2. (22901367)
2012
19
Development of a questionnaire (EORTC module) to measure quality of life in patients with cholangiocarcinoma and gallbladder cancer, the EORTC QLQ-BIL21. (21266979)
2011
20
Incidentally-discovered gallbladder cancer: When, why and which reoperation? (21478068)
2011
21
Two types of extended liver resection for advanced gallbladder cancer: how to do it. (21540601)
2011
22
Early-stage gallbladder cancer in the Surveillance, Epidemiology, and End Results database: effect of extended surgical resection. (21690451)
2011
23
Is gallbladder cancer decreasing in view of increasing laparoscopic cholecystectomy? (21677332)
2011
24
Lymph nodal involvement as prognostic factor in gallbladder cancer: location, count or ratio? (21487831)
2011
25
Comparative analysis between clinical outcomes of primary radical resection and second completion radical resection for T2 gallbladder cancer: single-center experience. (20333380)
2010
26
Significant association between toll-like receptor gene polymorphisms and gallbladder cancer. (20492496)
2010
27
Genetic variants involved in gallstone formation and capsaicin metabolism, and the risk of gallbladder cancer in Chilean women. (20082485)
2010
28
Gallbladder cancer presenting as an isolated large lung mass. (19851190)
2009
29
A case-control study of gallbladder cancer in hungary. (20104974)
2009
30
Gallbladder cancer: we need to do better! (19506960)
2009
31
Gallbladder cancer: adenoma-carcinoma or dysplasia-carcinoma sequence? (21960895)
2008
32
Prediction model for estimating the survival benefit of adjuvant radiotherapy for gallbladder cancer. (18378567)
2008
33
Re: gallbladder cancer: the role of laparoscopy and radical resection. (18791370)
2008
34
Geographic variation of gallbladder cancer mortality and risk factors in Chile: a population-based ecologic study. (18566990)
2008
35
Does PET-CT scan have a role prior to radical re-resection for incidental gallbladder cancer? (19088931)
2008
36
Expression of p21 and p27 in gallbladder cancer. (17457432)
2007
37
Haplotype analysis of signal peptide (insertion/deletion) and XbaI polymorphisms of the APOB gene in gallbladder cancer. (17696941)
2007
38
The standardized surgical approach improves outcome of gallbladder cancer. (17517122)
2007
39
Preneoplastic lesions in gallbladder cancer. (16724345)
2006
40
Application of modern imaging methods in diagnosis of gallbladder cancer. (16724342)
2006
41
Mirizzi syndrome and gallbladder cancer. (16858544)
2006
42
Laparoscopic cholecystectomy and gallbladder cancer. (16724350)
2006
43
Weekly gemcitabine for the treatment of biliary tract and gallbladder cancer. (14739669)
2004
44
Incidentally discovered gallbladder cancer: role of cryotherapy. (15282703)
2004
45
Gallbladder cancers rarely overexpress HER-2/neu, demonstrated by Hercep test. (15010878)
2004
46
A review of association of dietary factors in gallbladder cancer. (15659866)
2004
47
Gallbladder cancer gene hypermethylation: genetics or environment? (14527898)
2003
48
An autopsy case of gallbladder cancer developing in a Japanese man with cerebrotendinous xanthomatosis: genetic analysis of the sterol 27-hydroxylase and p53 genes. (12745462)
2003
49
Anomalous junction of the pancreaticobiliary duct accompanied by gallbladder cancer and obstructive jaundice in a patient with high serum and bile cytokine levels. (9719251)
1998
50
Alpha-fetoprotein, carcinoembryonic antigen, and carbohydrate antigen 19-9-producing gallbladder cancer. (8887046)
1996

Genetic Variations for Gallbladder Cancer

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Expression for genes affiliated with Gallbladder Cancer

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gallbladder Cancer

Search GEO for disease gene expression data for Gallbladder Cancer.

Pathways for genes affiliated with Gallbladder Cancer

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Compounds for genes affiliated with Gallbladder Cancer

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Gallbladder Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1tyrosine4411.1DPYD, CEACAM5, TRO, CYP7A1, IL32, MST1R
25-aza-2deoxycytidine4411.1CDX2, MLH1, HPSE, APC, TGFBR2, SNCG
3progesterone44 59 28 11 2415.1CYP7A1, MUC2, DPYD, MLH1, APC, TGFBR2
4paraffin4411.1CEACAM5, SERPINB5, APC, MUC2, CEACAM3, DPYD
5vegf4411.1PSG2, MLH1, DPYD, TYMS, HPSE, IL32
6calcium44 49 11 2414.1TGFBR2, HPSE, MUC2, CDX2, MLH1, SNCG
7glucose4411.0TGFBR2, CEACAM5, CEACAM3, HPSE, CYP7A1, PSG2
8crcs4411.0CEACAM5, TGFBR2, APC, MLH1, DPYD, MUC2
95fluorouracil4411.0MLH1, TYMS, DPYD, PSG2, CEACAM5, CEACAM3
10thymidine44 2412.0CEACAM3, DPYD, MLH1, PSG2, CDX2, TYMS
11cytosine44 2412.0PSG2, APC, MLH1, SERPINB5, CEACAM3, CEACAM5
12leucovorin44 49 1113.0PSG2, CEACAM3, CEACAM5, TYMS, DPYD
13irinotecan44 49 1113.0CEACAM5, MLH1, DPYD, TYMS, CEACAM3
145-fluorocytosine4411.0TYMS, PSG2, CEACAM3, CEACAM5
15cholesterol44 28 11 2414.0CEACAM5, MUC2, CCKAR, CCL27, CYP7A1, CEACAM3
16lipid4411.0CCL27, PSG2, CYP7A1, APC, CEACAM5, CCKAR
17estrogen4411.0SNCG, CYP7A1
18idurd4411.0MLH1, DPYD, TYMS
19oxaliplatin44 49 1112.9MLH1, DPYD, CEACAM5, TYMS
20cisplatin44 49 59 1113.9DPYD, CEACAM5, SERPINB5, GSTM3, TYMS, MLH1
21hematoxylin4410.9MUC2, PSG2, CEACAM3, CEACAM5
225-deoxy-5-fluorouridine4410.9CEACAM5, TYMS, DPYD
23steroid4410.9CEACAM3, CDX2, CYP7A1, SERPINB5
2418f fluorodeoxyglucose4410.9CEACAM3, CEACAM5, PSG2
25gemcitabine44 49 1112.9TYMS, HPSE, DPYD, MLH1
26mononucleotide4410.9APC, TGFBR2, MLH1
27tamoxifen44 49 28 1113.9TGFBR2, HPSE, SERPINB5, CEACAM3, TYMS
28metronidazole44 1111.9PSG2, CEACAM5, CEACAM3
29polynucleotide4410.9TGFBR2, CEACAM3, CEACAM5
30fudr4410.9PSG2, DPYD, TYMS
31thymidylate4410.9MLH1, CEACAM3, DPYD, TYMS
32eniluracil4410.8TYMS, DPYD
33sn 3844 5911.8MLH1, TYMS, DPYD
34p0024410.8MLH1, SERPINB5, CEACAM5, PSG2
35sulfate44 2411.8HPSE, CCKAR, MUC2, GSTM3
36tegafur-uracil4410.8TYMS, DPYD
37adriamycin4410.8CEACAM5, TYMS, PSG2, CEACAM3
38deoxycholic acid44 28 11 2413.8CYP7A1, MUC2, CDX2
39b 7234410.8CEACAM5, PSG2, CEACAM3
40sialic acid4410.7CEACAM3, CEACAM5
41doxorubicin44 49 1112.7TYMS, MLH1, PSG2, CEACAM3, CEACAM5
422-deoxyuridine-5-monophosphate4410.7TYMS, DPYD
43pyrimidine analogues4910.7DPYD, TYMS
44oligonucleotide4410.7TGFBR2, DPYD, APC, CDX2, MUC2, HPSE
45agarose4410.7MLH1, MUC2, HPSE, TGFBR2
46folate4410.6TYMS, APC, MLH1, DPYD
47methotrexate44 49 1112.5MUC2, DPYD, TYMS, CEACAM3
485-fluoro-2-deoxyuridine-5-monophosphate4410.5DPYD, TYMS
49indium4410.4PSG2, CEACAM3
50bvdu4410.2DPYD, TYMS

GO Terms for genes affiliated with Gallbladder Cancer

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Products for genes affiliated with Gallbladder Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gallbladder Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet