GBC
MCID: GLL018
MIFTS: 64

Gallbladder Cancer (GBC) malady

Cancer diseases, Liver diseases, Nephrological diseases categories

Summaries for Gallbladder Cancer

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Sources:
8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Your gallbladder is a pear-shaped organ under your liver. it stores bile, a fluid made by your liver to digest fat. as your stomach and intestines digest food, your gallbladder releases bile through a tube called the common bile duct. the duct connects your gallbladder and liver to your small intestine. cancer of the gallbladder is rare. it is more common in women and native americans. symptoms include jaundice (yellowing of the skin and whites of the eyes) pain above the stomach fever nausea and vomiting bloating lumps in the abdomen it is hard to diagnose gallbladder cancer in its early stages. sometimes doctors find it when they remove the gallbladder for another reason. but people with gallstones rarely have gallbladder cancer. because it is often found late, it can be hard to treat gallbladder cancer. treatment options include surgery, chemotherapy, radiation, or a combination. nih: national cancer institute

MalaCards: Gallbladder Cancer, also known as gallbladder carcinoma, is related to gallbladder disease and cholangiocarcinoma, and has symptoms including acute abdominal pain/colic, anorexia and nausea/vomiting/regurgitation/merycism/hyperemesis. An important gene associated with Gallbladder Cancer is HPSE (heparanase). The compounds tyrosine and 5-aza-2deoxycytidine have been mentioned in the context of this disorder. Affiliated tissues include the gallbladder, liver and lymph node, and related mouse phenotypes are digestive/alimentary and endocrine/exocrine gland.

Disease Ontology:8 A biliary tract cancer that is located in the gallbladder.

Wikipedia:63 Gallbladder cancer is a relatively uncommon cancer. It has peculiar geographical distribution being... more...

Aliases & Classifications for Gallbladder Cancer

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Liver diseases, Nephrological diseases


Characteristics (Orphanet epidemiological data):

48
gallbladder cancer:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Adulthood


Aliases & Descriptions:

gallbladder cancer 8 10 44 48 33
gallbladder carcinoma 8 10 44 60
malignant neoplasm of gallbladder 8 60
gallbladder neoplasm 8 60
malignant neoplasm of gallbladder localized 60
localized malignant gallbladder neoplasm 8
malignant tumor of the gallbladder 8
malignant tumour of gallbladder 8
carcinoma of the gallbladder 48
cancer of the gallbladder 8
tumor of the gallbladder 8
carcinoma of gallbladder 8
carcinoma gallbladder 8
gall bladder cancer 42
gallbladder ca 8
gbc 48


External Ids:

Disease Ontology8 DOID:3121, DOID:4948
NCIt39 C3048, C3844
MeSH34 D005706
ICD10 via Orphanet26 C23
SNOMED-CT via Orphanet57 372140005
UMLS via Orphanet61 C0235782
ICD1025 C23

Related Diseases for Gallbladder Cancer

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Gallbladder Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 171)
idRelated DiseaseScoreTop Affiliating Genes
1gallbladder disease30.8CCKAR, MUC2
2cholangiocarcinoma30.7PSG2, MUC2, CDX2, CEACAM3, CEACAM5
3hepatitis30.6CCL27
4pancreatic cancer30.3CCKAR, DPYD, MUC2, CDX2, IL32, SERPINB5
5pancreatitis30.3CCKAR
6neuroendocrine tumor30.3PSG2, CDX2, CEACAM3
7colorectal cancer30.1DPYD, TYMS, MUC2, CDX2, CYP7A1, HPSE
8adenocarcinoma30.1CCKAR, APC, PSG2, SNCG, MLH1, DPYD
9lung cancer30.1PSG2, TYMS, CDX2, CEACAM3, CEACAM5, TGFBR2
10sarcoma30.1SERPINB5, MLH1
11papillary carcinoma30.1MUC2, SERPINB5, CEACAM3
12squamous cell carcinoma30.1APC, PSG2, TGFBR2, MLH1, DPYD, TYMS
13hepatocellular carcinoma29.9MUC2, DPYD, PSG2, APC, CDX2, HPSE
14retinoblastoma29.9TGFBR2, TYMS, SNCG, APC
15colon cancer29.9TGFBR2, APC, PSG2, MLH1, DPYD, TYMS
16adenoma29.9APC, PSG2, MLH1, MUC2, CDX2, SERPINB5
17melanoma29.9PSG2, MLH1, CDX2, HPSE, SERPINB5, CEACAM3
18thyroid cancer29.9CCKAR, APC, SERPINB5
19cholelithiasis29.9CYP7A1, PSG2
20prostate cancer29.9TGFBR2, CEACAM3, SERPINB5, HPSE, CDX2
21neuroendocrine carcinoma10.6
22cholecystitis10.6
23spindle cell carcinoma10.6
24adenosquamous carcinoma10.6
25lymph node cancer10.5
26xanthogranulomatous cholecystitis10.5
27large cell carcinoma10.5
28pleomorphic carcinoma10.4
29vascular cancer10.3
30hepatitis a10.2
31connective tissue cancer10.2
32in situ carcinoma10.2
33gastrointestinal stromal tumor10.2
34von hippel-lindau disease10.2
35duodenitis10.2
36gall-bladder endocrine tumor10.2
37adenosquamous gallbladder carcinoma10.1
38abdominal aortic aneurysm10.1
39aortic aneurysm10.1
40gallbladder adenocarcinoma10.1
41obesity10.1
42tuberculosis10.1
43bullous pemphigoid10.1
44acute pancreatitis10.1
45gallbladder signet ring cell adenocarcinoma10.1
46cushing's syndrome10.1
47cribriform carcinoma10.1
48necrotizing fasciitis10.1
49spindle cell sarcoma10.1
50ulcerative colitis10.1

Graphical network of the top 20 diseases related to Gallbladder Cancer:



Diseases related to gallbladder cancer

Clinical Features for Gallbladder Cancer

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Sources:
48Orphanet
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Symptoms:

48
  • acute abdominal pain/colic
  • anorexia
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • hepatitis/icterus/cholestasis
  • lymphadenopathy/polyadenopathies
  • extrahepatic biliary tract/gallbladder neoplasm/tumor/carcinoma/cancer

Drugs & Therapeutics for Gallbladder Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Gallbladder Cancer

Drug clinical trials:

Search ClinicalTrials for Gallbladder Cancer

Search NIH Clinical Center for Gallbladder Cancer

Search CenterWatch for Gallbladder Cancer

Genetic Tests for Gallbladder Cancer

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Anatomical Context for Gallbladder Cancer

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Gallbladder Cancer:

32
Liver, Lymph node, Skin, Eye, Small intestine, Endothelial, Lung, Colon, Pancreas, Testes, Bone, Prostate, Bone marrow, Breast, Thyroid

FMA organs/tissues related to Gallbladder Cancer:

14
The gallbladder

Animal Models for Gallbladder Cancer or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Gallbladder Cancer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538110.6APC, MLH1, MUC2, CDX2, CYP7A1, TGFBR2
2MP:000537910.3MST1R, HPSE, CDX2, MUC2, MLH1, CCKAR

Publications for Gallbladder Cancer

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Sources:
50PubMed
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Articles related to Gallbladder Cancer:

(show top 50)    (show all 541)
idTitleAuthorsYear
1
Ability of FDG-PET/CT in the detection of gallbladder cancer. (24165875)
2014
2
The role of staging laparoscopy in primary gall bladder cancer--an analysis of 409 patients: a prospective study to evaluate the role of staging laparoscopy in the management of gallbladder cancer. (23059504)
2013
3
Association of genetic variants of cancer stem cell gene CD44 haplotypes with gallbladder cancer susceptibility in North Indian population. (24186075)
2013
4
Clinicopathological significance of SLP-2 overexpression in human gallbladder cancer. (23918306)
2013
5
Radical lymph node dissection and assessment: Impact on gallbladder cancer prognosis. (23964151)
2013
6
CT of gallbladder cancer and its mimics: a pattern-based approach. (22581235)
2013
7
The expression of Nek7, FoxM1, and Plk1 in gallbladder cancer and their relationships to clinicopathologic features and survival. (23359173)
2013
8
Missense allele of a single nucleotide polymorphism rs2294008 attenuated antitumor effects of prostate stem cell antigen in gallbladder cancer cells. (23599686)
2013
9
Xanthogranulomatous cholecystitis mimicking gallbladder cancer and causing obstructive cholestasis. (23060404)
2012
10
Diagnosis and management of gallbladder cancer. (22866265)
2012
11
Definition of T3/4 and regional lymph nodes in gallbladder cancer: which is more valid, the UICC or the Japanese staging system? (22890597)
2012
12
Strategies for diagnosis of xanthogranulomatous cholecystitis masquerading as gallbladder cancer. (22340475)
2012
13
Radical resection of gallbladder cancer: could it be robotic? (22648103)
2012
14
Relevance of residual disease after liver resection for incidental gallbladder cancer. (22762403)
2012
15
High expression of CXCR4 and CXCR7 predicts poor survival in gallbladder cancer. (21986127)
2011
16
Nomogram for predicting the benefit of adjuvant chemoradiotherapy for resected gallbladder cancer. (22067404)
2011
17
Clinical implication of bile spillage in patients undergoing laparoscopic cholecystectomy for gallbladder cancer. (21679636)
2011
18
Preliminary screening and identification of stem cell-like sphere clones in a gallbladder cancer cell line GBC-SD. (21462380)
2011
19
Helicobacter bilis in human gallbladder cancer: results of a case-control study and a meta-analysis. (20843113)
2010
20
Epidemiology of gallbladder cancer. (20478488)
2010
21
Laparoscoendoscopic single-site cholecystectomy and occult gallbladder cancer. (20054569)
2010
22
Can EUS-guided FNA distinguish between gallbladder cancer and xanthogranulomatous cholecystitis? (20630515)
2010
23
Comment on: Lifestyle, reproductive factors and risk of gallbladder cancer. (19960170)
2009
24
Complement receptor 1 (A3650G RsaI and intron 27 HindIII) polymorphisms and risk of gallbladder cancer in north Indian population. (19906204)
2009
25
Single nucleotide polymorphism in the ABCG8 transporter gene is associated with gallbladder cancer susceptibility. (19018975)
2009
26
Lymph node evaluation is associated with improved survival after surgery for early stage gallbladder cancer. (19789030)
2009
27
Gallbladder cancer manifesting as recurrent common bile duct stone and duodenal ulcer bleeding. (19687000)
2009
28
Enhanced expression of trophinin promotes invasive and metastatic potential of human gallbladder cancer cells. (18846386)
2009
29
Gallbladder cancer and radical surgery. (18791371)
2008
30
Survival prediction models for estimating the benefit of post-operative radiation therapy for gallbladder cancer and lung cancer. (18999217)
2008
31
Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer. (18692501)
2008
32
Genetic susceptibility of epidermal growth factor +61A>G and transforming growth factor beta1 -509C>T gene polymorphisms with gallbladder cancer. (18571008)
2008
33
No association of Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in susceptibility to gallbladder cancer. (17979520)
2008
34
Association of CYP1A1 Msp1 polymorphism with tobacco-related risk of gallbladder cancer in a north Indian population. (18287863)
2008
35
CCR5 Delta32 polymorphism: associated with gallbladder cancer susceptibility. (18405329)
2008
36
Predisposed to toxins: association of gallbladder cancer with N-acetyl transferase SNPs. (17297302)
2007
37
Distribution of natural killer cells and T-lymphocyte subsets in peripheral blood, gallbladder cancer and surrounding tissue. (17287172)
2007
38
Advanced gallbladder cancer: Indian "middle path". (17653634)
2007
39
Can we do better than 'incidental' gallbladder cancer? (18265629)
2007
40
Antitumor effect of gemcitabine on orthotopically inoculated human gallbladder cancer cells in nude mice. (17235714)
2007
41
Recent trends of gallbladder cancer in Japan: an analysis of 4,770 patients. (17594719)
2007
42
Does laparoscopy worsen the prognosis for incidental gallbladder cancer? (16362480)
2006
43
Correlates between vegetable consumption and gallbladder cancer. (16523010)
2006
44
Gallbladder cancer in India: a dismal picture. (15683437)
2005
45
Frozen shoulder as the initial presentation of gallbladder cancer diagnosed by fine needle aspiration cytology. (15966303)
2005
46
Laparoscopic cholecystectomy for treatment of unexpected early-stage gallbladder cancer. (16121343)
2005
47
Analysis of prognostic factors after surgery for stage III and IV gallbladder cancer. (15336729)
2004
48
Gallbladder cancer: lessons from a rare tumour. (15343276)
2004
49
Laparoscopic cholecystectomy: its effect on the prognosis of patients with gallbladder cancer. (15366742)
2004
50
E1A, E1B double-restricted adenovirus for oncolytic gene therapy of gallbladder cancer. (12907616)
2003

Genetic Variations for Gallbladder Cancer

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Expression for genes affiliated with Gallbladder Cancer

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gallbladder Cancer

Search GEO for disease gene expression data for Gallbladder Cancer.

Pathways for genes affiliated with Gallbladder Cancer

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Compounds for genes affiliated with Gallbladder Cancer

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB
See all sources

Compounds related to Gallbladder Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1tyrosine4411.1DPYD, CEACAM5, TRO, CYP7A1, IL32, MST1R
25-aza-2deoxycytidine4411.1CDX2, MLH1, HPSE, APC, TGFBR2, SNCG
3progesterone44 59 28 11 2415.1CYP7A1, MUC2, DPYD, MLH1, APC, TGFBR2
4paraffin4411.1CEACAM5, SERPINB5, APC, MUC2, CEACAM3, DPYD
5vegf4411.1PSG2, MLH1, DPYD, TYMS, HPSE, IL32
6calcium44 49 11 2414.1TGFBR2, HPSE, MUC2, CDX2, MLH1, SNCG
7glucose4411.0TGFBR2, CEACAM5, CEACAM3, HPSE, CYP7A1, PSG2
8crcs4411.0CEACAM5, TGFBR2, APC, MLH1, DPYD, MUC2
95fluorouracil4411.0MLH1, TYMS, DPYD, PSG2, CEACAM5, CEACAM3
10thymidine44 2412.0CEACAM3, DPYD, MLH1, PSG2, CDX2, TYMS
11cytosine44 2412.0PSG2, APC, MLH1, SERPINB5, CEACAM3, CEACAM5
12leucovorin44 49 1113.0PSG2, CEACAM3, CEACAM5, TYMS, DPYD
13irinotecan44 49 1113.0CEACAM5, MLH1, DPYD, TYMS, CEACAM3
145-fluorocytosine4411.0TYMS, PSG2, CEACAM3, CEACAM5
15cholesterol44 28 11 2414.0CEACAM5, MUC2, CCKAR, CCL27, CYP7A1, CEACAM3
16lipid4411.0CCL27, PSG2, CYP7A1, APC, CEACAM5, CCKAR
17estrogen4411.0SNCG, CYP7A1
18idurd4411.0MLH1, DPYD, TYMS
19oxaliplatin44 49 1112.9MLH1, DPYD, CEACAM5, TYMS
20cisplatin44 49 59 1113.9DPYD, CEACAM5, SERPINB5, GSTM3, TYMS, MLH1
21hematoxylin4410.9MUC2, PSG2, CEACAM3, CEACAM5
225-deoxy-5-fluorouridine4410.9CEACAM5, TYMS, DPYD
23steroid4410.9CEACAM3, CDX2, CYP7A1, SERPINB5
2418f fluorodeoxyglucose4410.9CEACAM3, CEACAM5, PSG2
25gemcitabine44 49 1112.9TYMS, HPSE, DPYD, MLH1
26mononucleotide4410.9APC, TGFBR2, MLH1
27tamoxifen44 49 28 1113.9TGFBR2, HPSE, SERPINB5, CEACAM3, TYMS
28metronidazole44 1111.9PSG2, CEACAM5, CEACAM3
29polynucleotide4410.9TGFBR2, CEACAM3, CEACAM5
30fudr4410.9PSG2, DPYD, TYMS
31thymidylate4410.9MLH1, CEACAM3, DPYD, TYMS
32eniluracil4410.8TYMS, DPYD
33sn 3844 5911.8MLH1, TYMS, DPYD
34p0024410.8MLH1, SERPINB5, CEACAM5, PSG2
35sulfate44 2411.8HPSE, CCKAR, MUC2, GSTM3
36tegafur-uracil4410.8TYMS, DPYD
37adriamycin4410.8CEACAM5, TYMS, PSG2, CEACAM3
38deoxycholic acid44 28 11 2413.8CYP7A1, MUC2, CDX2
39b 7234410.8CEACAM5, PSG2, CEACAM3
40sialic acid4410.7CEACAM3, CEACAM5
41doxorubicin44 49 1112.7TYMS, MLH1, PSG2, CEACAM3, CEACAM5
422-deoxyuridine-5-monophosphate4410.7TYMS, DPYD
43pyrimidine analogues4910.7DPYD, TYMS
44oligonucleotide4410.7TGFBR2, DPYD, APC, CDX2, MUC2, HPSE
45agarose4410.7MLH1, MUC2, HPSE, TGFBR2
46folate4410.6TYMS, APC, MLH1, DPYD
47methotrexate44 49 1112.5MUC2, DPYD, TYMS, CEACAM3
485-fluoro-2-deoxyuridine-5-monophosphate4410.5DPYD, TYMS
49indium4410.4PSG2, CEACAM3
50bvdu4410.2DPYD, TYMS

GO Terms for genes affiliated with Gallbladder Cancer

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Products for genes affiliated with Gallbladder Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gallbladder Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet