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MCID: GLL018

Gallbladder Cancer malady
18 drugs, 120 genes, 8 tissues, 1616 related diseases, 29 phenotypes, 89 articles, clinical trials.

Summaries for Gallbladder Cancer

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6Disease Ontology, 22MalaCards
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Disease Ontology: A biliary tract cancer that is located in the gallbladder.6

MalaCards: Gallbladder Cancer, also known as malignant neoplasm of gallbladder, is related to tongue cancer and thyroid cancer. An important gene associated with Gallbladder Cancer is HPSE (heparanase), and among its related pathways are Colorectal cancer and Glioma Invasiveness. The drugs dexamethasone and prednisone and the compounds egcg and h2o2 have been mentioned in the context of this disorder. Affiliated tissues include the gallbladder, bone marrow and lymph node, and related mouse phenotypes are respiratory system and craniofacial.

Aliases & Descriptions for Gallbladder Cancer

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6Disease Ontology, 30NIH Rare Diseases, 43UMLS, 40SNOMED-CT, 27NCIt, 24MeSH
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Aliases & Descriptions:

gallbladder cancer 6
malignant neoplasm of gallbladder 6 43
gallbladder neoplasm 6 43
malignant neoplasm of gallbladder localized 43
localized malignant gallbladder neoplasm 6
malignant tumor of the gallbladder 6
malignant tumour of gallbladder 6
tumor of the gallbladder 6
gallbladder carcinoma 43
gall bladder cancer 30
malignant neoplasms 43
gallbladder ca 6
neoplasms 43

Related Diseases for Gallbladder Cancer

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13GeneCards, 14GeneDecks
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Diseases related to gallbladder cancer by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1613)
idRelated DiseaseScoreTop Affiliating Genes
1tongue cancer32.4VEGFC, CDH1, MMP2, MMP9
2thyroid cancer31.6SERPINB5, S100A4, APC, KRT20, KRT19, NME1
3colonic neoplasm31.3BCL2, CD44, CDH1, TP53, CTNNB1, TYMS
4ovarian cancer30.8CEACAM3, FSCN1, ERBB2, KRAS, NME1, PGR
5ovarian mucinous neoplasm30.5CDX2, MMP9, TP53, KRT20
6intestinal neoplasm30.2MMP2, MMP9, APC, PTGS2, KRAS
7vulva cancer30.1TP53, KRT20, EGFR
8intraepithelial neoplasm29.9PCNA, MUC1, MUC2, XRCC1, CDKN2A, ERBB2
9anaplastic carcinoma29.9MUC1, S100A4, CEACAM3, CDH1, FHIT, KRT20
10skin benign neoplasm29.8MSH2, MMP13, MLH1, MGMT, HRAS, ERCC2
11brain cancer29.8VEGFA, HRAS, TP73, PTEN, EGFR
12neuroendocrine tumor29.6NCAM1, RASSF1, CEACAM3, CDX2, SST, KRT20
13nasopharynx carcinoma29.5VEGFA, RASSF1, CDKN2A, CDH1, MMP9, CCND1
14salivary gland cancer29.4SERPINB5, MMP13, MMP9, MET, CASP3, CASP8
15granular cell tumor29.3BCL2, CEACAM3, CASP3, PTEN, EGF
16gastrointestinal stromal tumor29.1NAT2, CDX2, APC, PTGS2, CTNNB1
17penile cancer29.0PIK3CA, CDKN2A, HRAS, KRAS
18lynch syndrome28.9MSH2, MLH1, HRAS, TP53, NRAS, KRAS
19myoma28.9PCNA, FGF2, CCND1, ESR1, ERCC2, PTGS2
20basal cell carcinoma28.9BCL2, XRCC1, CD44, MMP1, MMP13, GSTM1
21rectum cancer28.6CEACAM5, CEACAM3, TYMS, DPYD
22oral cavity cancer28.5NAT2, VEGFA, GSTM1, GSTT1, CASP8, ERBB2
23mesenchymal cell neoplasm28.4PCNA, CD44, CCND1, CASP3, HRAS
24ocular cancer28.3VEGFA, VEGFC, CASP3, TGFB1
25lipoma28.3CDKN2A, CDK4, TNF, PTEN, CXCR7, PGR
26squamous cell carcinoma28.1CD44, CDH1, GSTP1, CCND1, TP73, KRT19
27adenoid cystic carcinoma27.9NCAM1, PCNA, SERPINB5, RASSF1, MUC1, CEACAM3
28myelodysplastic syndrome27.7FHIT, GSTM1, GSTT1, NRAS, CR1, KRAS
29cholecystitis27.7PCNA, CDH13, IL6, CCKAR, TP53, TNF
30male breast cancer27.6PCNA, ESR1, ERBB2, PGR
31pancreatic cancer27.6SERPINB5, VEGFA, MUC1, MUC2, CEACAM5, CEACAM3
32malignant peripheral nerve sheath tumor27.6NCAM1, CDKN2A, CD44, MMP13, EGFR, TOP2A
33oligodendroglioma27.5CDKN2A, MGMT, TP73, PTEN, EGFR
34urinary bladder cancer27.5SERPINB5, NAT2, RASSF1, MUC2, CDKN2A, CDH1
35bile duct carcinoma27.5VEGFC, BCL2, MUC1, MUC2, FSCN1, CDKN2A
36pleomorphic adenoma27.4PCNA, SERPINB5, MUC1, CDKN1B, HRAS, ERBB2
37bile duct cancer27.4NCAM1, VEGFA, BCL2, CEACAM3, FSCN1, CDKN2A
38cardia cancer27.4MTHFR, XRCC1, CDKN2A, CD44, GSTM1, GSTP1
39dermatofibrosarcoma protuberans27.3MUC1, MMP1, MMP14, MMP2, TP53, PTGS2
40breast cancer27.2PIK3CA, SERPINB5, S100A4, MST1R, CDKN1B, CDK4
41adenomatoid tumor27.2MUC1, CEACAM5, MMP2, PSG2
42pituitary tumor27.2NCAM1, CDKN1B, FGF2, APC, ESR1, ESR2
43bronchogenic carcinoma27.1CEACAM5, CDKN2A, GSTM3, IL1RN, TP53, TNF
44craniopharyngioma27.1PCNA, RARB, CEACAM3, CDX2, IL6, ERBB2
45obstructive jaundice27.1IL6, CCL27, TNF, TLR4, TGFB1, PSG2
46polymorphous low-grade adenocarcinoma27.1PCNA, SERPINB5, MUC1, CEACAM3
47mucinous cystadenocarcinoma27.0PCNA, MUC1, CEACAM3, PSG2
48b-cell lymphomas27.0BCL2, FSCN1, CDKN1B, CDKN2A, CDK4, CD44
49stomach carcinoma26.9RASSF1, CEACAM5, CDKN2A, CD44, CDH1, MLH1
50myeloid malignancy26.8CDKN1B, GSTM1, GSTT1, TP53, NRAS, CXCR7

Graphical network of the top 20 diseases related to gallbladder cancer:



Graphical network of diseases related to gallbladder cancer

Clinical Features for Gallbladder Cancer

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Drugs & Therapeutics for Gallbladder Cancer

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

Search CenterWatch for gallbladder cancer

Drug clinical trials:

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Search CenterWatch for gallbladder cancer

Inferred drug relations via UMLS/NDF-RT:

43 28 dexamethasone, dexamethasone acetate, dexamethasone acetate pwdr [va product], dexamethasone phosphate, dexamethasone sodium phosphate, dexamethasone sodium phosphate pwdr [va product], linolenic acid, methylprednisolone, methylprednisolone acetate, methylprednisolone sodium succinate, prednisolone, prednisolone acetate, prednisolone acetate pwdr [va product], prednisolone pwdr [va product], prednisolone sodium phosphate, prednisolone tebutate, prednisone, prednisone pwdr [va product]

Genetic Tests for Gallbladder Cancer

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Anatomical Context for Gallbladder Cancer

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11FMA, 22MalaCards
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MalaCards organs/tissues related to gallbladder cancer:

22
Bone marrow, Lymph node, Liver, Nk cells, T cells, B cells, Endothelial

FMA organs/tissues related to gallbladder cancer:

11
The gallbladder

Phenotypes for genes affiliated with Gallbladder Cancer

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25MGI
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MGI Mouse Phenotypes related to gallbladder cancer:

25 (show all 29)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1respiratory system phenotypeMP:000538810.7NEDD4L, CXCR7
2craniofacial phenotypeMP:000538210.4NFE2L2, TP73, ZEB1
3endocrine/exocrine gland phenotypeMP:000537910.1MST1R, ZEB1, LRPAP1, CDKN1B, CDX2, CCKAR
4normal phenotypeMP:00028739.3CYP1A1, LRPAP1, VEGFA, RARB, TRO, ESR2
5other phenotypeMP:00053959.2NME1, TLR2, ABCB1, PTGS2, TP73, ESR2
6embryogenesis phenotypeMP:00053809.1PGR, NME1, CXCR4, EGFR, RARB, SERPINB5
7liver/biliary system phenotypeMP:00053708.9TLR4, TLR2, ABCG8, VEGFA, MET, IL6
8hematopoietic system phenotypeMP:00053978.7EBAG9, FHIT, CDK4, MST1R, MSH2, ZEB1
9pigmentation phenotypeMP:00011868.4TIMP3, TLR4, EGFR, KRAS, CTNNB1, PTEN
10hearing/vestibular/ear phenotypeMP:00053778.4TP73, CTGF, CTNNB1, EGFR, ABCB1, ESR2
11behavior/neurological phenotypeMP:00053868.3TGFBR2, ERCC2, ESR2, HRAS, CCKAR, CCR5
12nervous system phenotypeMP:00036318.2NME1, CXCR7, CXCR4, TGFB1, TIMP2, TLR4
13renal/urinary system phenotypeMP:00053678.0NEDD4L, APC, MET, MMP14, CDK4, CDKN1B
14immune system phenotypeMP:00053877.8TNF, S100A4, MUC2, ZEB1, MSH2, MST1R
15limbs/digits/tail phenotypeMP:00053717.8ESR2, ERBB2, CTGF, CTNNB1, NRAS, KRAS
16adipose tissue phenotypeMP:00053757.2TP53, TNF, PTEN, PTGS2, EGFR, TLR2
17no phenotypic analysisMP:00030127.2TP53, ESR2, ESR1, HRAS, PTGS2, CYP1A1
18integument phenotypeMP:00107716.7PDPN, MLH1, MMP13, CD44, CDK4, CDKN1B
19reproductive system phenotypeMP:00053896.5AFP, NME1, TGFB1, THBS1, TIMP3, CASP3
20skeleton phenotypeMP:00053906.2PGR, CXCR4, TGFBR2, THBS1, EGFR, KRT19
21growth/size phenotypeMP:00053785.8HGF, NME1, TGFBR2, THBS1, TIMP3, TLR4
22digestive/alimentary phenotypeMP:00053815.6NEDD4L, NFE2L2, NRAS, CTNNB1, CTGF, SST
23mortality/agingMP:00107685.3AFP, NEDD4L, NMT1, NME1, CXCR7, TGFBR2
24muscle phenotypeMP:00053695.0ZEB1, BCL2, RARB, VEGFA, PIK3CA, CDKN1B
25vision/eye phenotypeMP:00053914.0CTNNB1, CTGF, CYP7A1, PTGS2, PTEN, TNF
26cellular phenotypeMP:00053843.4ERBB2, FGF2, GSTM1, MLH1, MMP9, MMP14
27tumorigenesisMP:00020062.7CDK4, PIK3CA, RASSF1, BCL2, CDX2, CDH13
28cardiovascular system phenotypeMP:00053852.1APC, CDX2, CDH13, CDKN1B, MUC2, ZEB1
29homeostasis/metabolism phenotypeMP:00053760.5TP53, APC, IL6, IL1RN, IL1B, MET

Publications for genes affiliated with Gallbladder Cancer

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35PubMed
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Articles related to gallbladder cancer:

(show top 50)    (show all 89)
idTitleAuthorsYearAffiliating Genes
1ERCC1 (excision repair cross-complementing 1) express ion in pT2 gallbladder cancer is a prognostic factor. (21117025)Roa I.... Munoz S.2011ERCC1
2Expression profile of cholecystokinin type-A receptor in gallbladder cancer and gallstone disease. (21813391)Rai R.... Shukla H.S.2011CCKAR
3Gallbladder cancer predisposition: a multigenic appro ach to DNA-repair, apoptotic and inflammatory pathway genes. (21283657)Srivastava K.... Mittal B.2011PTGS2
4The risk factor of gallbladder cancer: hyperplasia of mucous epithelium caused by gallstones associates with p16/CyclinD1/CDK4 pathw ay. (21777578)Feng Z.... Zhao F.2011CDK4, CCND1, CDKN2A
5High expression of CXCR4 and CXCR7 predicts poor surv ival in gallbladder cancer. (21986127)Yao X.... Chen Y.2011CXCR4, CXCR7
6Nedd4L modulates the transcription of metalloproteina se-1 and -13 genes to increase the invasive activity of gallbladder cancer. (21039987)Takeuchi T.... Furihata M.2011MMP13, MMP1, NEDD4L
7Vascular endothelial growth factor-C promotes the gro wth and invasion of gallbladder cancer via an autocrine mechanism. (20734221)Chen Y.... Zhu J.2010VEGFC
8Evidence that genetic variants of metabolic detoxicat ion and cell cycle control are not related to gallbladder cancer risk in Chilea n women. (20544687)Tsuchiya Y.... Yamamoto M.2010TP53, CYP1A1, GSTM1
9Alterations of p53 gene in gallbladder cancer patient s of North India. (20862982)Nigam P.... Choudhuri G.2010TP53
10Significant association between toll-like receptor ge ne polymorphisms and gallbladder cancer. (20492496)Srivastava K.... Mittal B.2010TLR2, TLR4
11Inducible costimulator (ICOS) enhances the cytolytic activity of cytokine-induced killer cells against gallbladder cancer in vitro and in vivo. (19194830)Wang J.... Wang Y.2009ICOS
12Functional polymorphisms of the cyclooxygenase (PTGS2 ) gene and risk for gallbladder cancer in a North Indian population. (19455278)Srivastava K.... Mittal B.2009PTGS2
13Complement receptor 1 (A3650G RsaI and intron 27 Hind III) polymorphisms and risk of gallbladder cancer in north Indian population. (19906204)Srivastava A.... Mittal B.2009CR1
14The expression of matrix metalloproteinases in intrahepatic cholangiocarcinoma, hilar (Klatskin tumor), middle and distal extrahepatic cholangiocarcinoma, gallbladder cancer, and ampullary carcinoma: role of matrix metalloproteinases in tumor progression and prognosis. (19330734)KirimlioA9lu H.... KirimlioA9lu V.2009MMP2, MMP9, MMP14
15Zeb1-mediated T-cadherin repression increases the invasive potential of gallbladder cancer. (19116147)Adachi Y.... Furihata M.2009CDH13, ZEB1
16IL-1 gene polymorphisms and genetic susceptibility of gallbladder cancer in a north Indian population. (18940468)Vishnoi M.... Mittal B.2008IL1B, IL1RN
17Gene expression profiles in gallbladder cancer: the close genetic similarity seen for early and advanced gallbladder cancers may explain the poor prognosis. (18497548)Kim J.H.... Lowe A.W.2008PAK4
18No association of Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in susceptibility to gallbladder cancer. (17979520)Srivastava A.... Mittal B.2008MTHFR
19Cholecystokinin receptor A gene polymorphism in gallstone disease and gallbladder cancer. (17944886)Srivastava A.... Mittal B.2008CCKAR
20Heparanase and gallbladder cancer: new insights into understanding tumor growth and invasion. (18318817)Dutta U.... Poornachandra K.S.2008HPSE
21Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer. (18692501)Shibata T.... Hirohashi S.2008NFE2L2, KEAP1
22Single nucleotide polymorphism in the ABCG8 transporter gene is associated with gallbladder cancer susceptibility. (19018975)Srivastava A.... Mittal B.2008ABCG8
23Genetic susceptibility of epidermal growth factor +61A>G and transforming growth factor beta1 -509C>T gene polymorphisms with gallbladder cancer. (18571008)Vishnoi M.... Mittal B.2008EGF, TGFB1
24Association of CYP1A1 Msp1 polymorphism with tobacco-related risk of gallbladder cancer in a north Indian population. (18287863)Pandey S.N.... Mittal B.2008CYP1A1
25Successful treatment of advanced gallbladder cancer with an anticancer drug S-1: assessment based on intratumoral gene. (19093184)Kitajima K.... Yanaga K.2008DPYD
26Diagnosis and surgical management of gallbladder cancer: a review. (17468929)Reid K.M.... Donohue J.H.2007KRAS
27Polymorphisms of cytochrome P450 1A1, glutathione S-transferase class mu, and tumour protein p53 genes and the risk of developing gallbladder cancer in Japanese. (17531965)Tsuchiya Y.... Yamamoto M.2007TP53, CYP1A1, GSTM1
28Hypermethylation of the Ras association domain family 1A (RASSF1A) gene in gallbladder cancer. (18182852)Kee S.K.... Kim D.S.2007KRAS, RASSF1
29Isolation of a human gallbladder cancer cell clone with high invasive phenotype in vitro and metastatic potential in orthotopic model and inhibition of its invasiveness by heparanase antisense oligodeoxynucleotides. (17260103)Chang X.Z.... Shao Z.M.2007HPSE
30Slow acetylator genotype of N-acetyl transferase2 (NAT2) is associated with increased susceptibility to gallbladder cancer: the cancer risk not modulated by gallstone disease. (17224641)Pandey S.N.... Mittall B.2007NAT2
31hOGG1 Ser326Cys polymorphism and susceptibility to gallbladder cancer in a Chinese population. (17417784)Jiao X.... Ce B.2007OGG1
32Thymidylate synthase and dihydropyrimidine dehydrogenase expressions in gallbladder cancer. (16619549)Ajiki T.... Kuroda Y.2006TYMS, DPYD
33Preliminary study of p53 and c-erbB-2 expression in gallbladder cancer in Indian patients manuscript id: 8962091628764582. (16686942)Chaube A.... Shukla H.S.2006ERBB2, TP53
34Lipoprotein Receptor Associated Protein (LRPAP1) Insertion/Deletion Polymorphism: Association with Gallbladder Cancer Susceptibility. (17987404)Pandey S.N.... Mittal B.2006LRPAP1
35Granulocyte-colony stimulating factor-producing gallbladder cancer without recurrence more than 2 years after resection: report of a case. (15976958)Ikeda T.... Maehara Y.2005CSF3
36Do the progesterone receptors have a role to play in gallbladder cancer? (15722575)Baskaran V.... Nundy S.2005PGR, ESR1
37Cisplatin represses transcriptional activity from the minimal promoter of the O6-methylguanine methyltransferase gene and increases sensitivity of human gallbladder cancer cells to 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-2-chloroethyl)-3-nitrosourea. (15809756)Sato K.... Miyazaki K.2005MGMT
38Expression and significance of PTEN and nm23 in the metastasis of gallbladder cancer (15875318)Zheng C.L.... Huang Y.2005PTEN, NME1
39Detection of bone marrow micrometastases in patients with gallbladder cancer (15743160)Roa J.C.... Roa I.2004KRT19, CEACAM5, KRT20
40A MEK inhibitor (U0126) markedly inhibits direct liver invasion of orthotopically inoculated human gallbladder cancer cells in nude mice. (15743030)Horiuchi H.... Fujimori T.2004MMP2, MMP9, TIMP2
41Gallbladder cancers rarely overexpress HER-2/neu, demonstrated by Hercep test. (15010878)Matsuyama S.... Miyazaki K.2004ERBB2
42Apolipoprotein B-100 XbaI gene polymorphism in gallbladder cancer. (14618390)Singh M.K.... Mittal B.2004APOB
43Relationship between urokinase-type plasminogen activator receptor and vascular endothelial growth factor expression and metastasis of gallbladder cancer. (15309734)Yue S.Q.... Dou K.F.2004PLAUR
44Immunohistochemical analysis of transforming growth factor beta in gallbladder cancer. (12579267)Kitamura K.... Koyanagi Y.2003TGFB1
45Vascular endothelial growth factor-C expression in human gallbladder cancer and its relationship to lymph node metastasis. (12469214)Nakashima T.... Okita K.2003VEGFC
46Genetic polymorphisms of cytochrome P450 1A1 and risk of gallbladder cancer. (12071517)Tsuchiya Y.... Yamamoto M.2002CYP1A1
47Prognostic significance of S100A4 expression in gallbladder cancer. (11956586)Nakamura T.... Kuroda Y.2002S100A4
48The role of E-cadherin in the differentiation of gallbladder cancer cells. (11683173)Mukai S.... Yakushiji H.2001CDH1
49Neural cell adhesion molecule and perineural invasion in gallbladder cancer. (7844990)Seki H.... Umezawa A.1995NCAM1
50Gallbladder cancer: immunohistochemical expression of CA-19-9, epithelial membrane antigen, dupan-2 and carcinoembryonic antigen (1340939)Roa I.... de Aretxabala X.1992CEACAM3

Expression for genes affiliated with Gallbladder Cancer

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Gallbladder Cancer

Pathways for genes affiliated with Gallbladder Cancer

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20KEGG, 36QIAGEN, 10EMD Millipore, 41Thomson Reuters
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Pathways related to gallbladder cancer according to GeneDecks:

(show top 50)    (show all 180)
idPathwayScoreTop Affiliating Genes
1Colorectal cancer2010.6TGFBR2, TGFB1, MSH2
2Glioma Invasiveness3610.3VEGFC, CD44, FIGF, FGF2, NRAS, PLAUR
3Glioblastoma Multiforme369.7EGFR, CDKN1B, CDK4, MGMT, APC, HRAS
414-3-3 Induced Intracellular Signaling369.5VEGFC, MST1R, FIGF, FGF2, HRAS, ERBB2
5Breast Cancer Regulation by Stathmin1369.5EGFR, EGF, ERBB2, TIMP3, FIGF, MST1R
6Akt Signaling369.4NRAS, TIMP3, CXCR4, HGF, CTGF, TNF
7Epithelial Adherens Junctions369.4VEGFC, TGFBR2, TIMP3, TIMP2, TIMP1, EGFR
8Cell adhesion ECM remodeling109.4MMP9, MMP2, PLAUR, TIMP1, TIMP2, TIMP3
9Paxillin Interactions369.3TIMP1, TIMP3, TIMP2, EGF, EGFR, CTGF
10Cell adhesion_ECM remodeling419.3MMP14, CD44, MMP1, MMP13, TIMP3, TIMP2
11Rac1 Pathway369.2TGFB1, FIGF, FGF2, MET, HGF, TIMP3
12Ras Pathway369.1VEGFC, TIMP1, TIMP2, TIMP3, PAK4, MST1R
13JNK Pathway369.1TGFB1, EGF, NRAS, TP53, HRAS, IL6
14PPAR Pathway369.1TIMP2, EGFR, NRAS, VEGFC, FIGF, FGF2
15Non-small cell lung cancer209.1CDK4, FHIT, HRAS, ERBB2, NRAS, KRAS
16Endometrial cancer208.9TP53, PTEN, CTNNB1, NRAS, KRAS, EGF
17Glioma208.8CDKN2A, CDK4, CCND1, HRAS, TP53, PTEN
18Rho Family GTPases368.8BCL2, PAK4, HGF, CSF3, TGFB1, TIMP3
19Nanog in Mammalian ESC Pluripotency368.7HGF, TGFB1, VEGFC, MST1R, FIGF, FGF2
20Melanoma208.7PIK3CA, CDKN2A, CDK4, CDH1, MET, CCND1
21Malaria208.7TNF, HGF, TLR4, TLR2, CR1, TGFB1
22eNOS Signaling368.6HGF, TGFB1, TIMP2, TIMP1, EGFR, MST1R
23GPCR Pathway368.4FIGF, PAK4, VEGFC, FGF2, ERBB2, MET
24Focal adhesion208.4BCL2, FIGF, MET, CCND1, HRAS, EGF
25Prostate cancer208.4PIK3CA, BCL2, CDKN1B, GSTP1, CCND1, HRAS
26Apoptotic Pathways in Synovial Fibroblasts368.3CTGF, EGF, EGFR, TIMP1, TIMP2, TIMP3
27Bladder cancer208.3VEGFC, RASSF1, CDKN2A, CDK4, CDH1, MMP1
28TGF-Beta Pathway368.2VEGFC, BCL2, CDH1, FIGF, FGF2, MET
29ILK Signaling368.1TIMP3, TIMP2, TIMP1, EGFR, EGF, VEGFC
30NF-KappaB (p50-p65) Pathway368.1IL6, TNF, CTGF, EGF, EGFR, TLR2
31Mitochondrial Apoptosis368.1VEGFC, BCL2, CDKN2A, FIGF, FGF2, MET
32p53 Mediated Apoptosis368.1VEGFC, BCL2, FIGF, FGF2, MET, IL6
33NF-KappaB Family Pathway368.0IL6, IL1B, MET, FGF2, FIGF, VEGFC
34JAK-STAT Pathway368.0MET, IL1B, IL6, CCL27, HRAS, ERBB2
35DHA Signaling367.9EGFR, TIMP1, TIMP2, TIMP3, TGFB1, HGF
36ERK Signaling367.9VEGFC, PAK4, MST1R, FIGF, IL1B, IL6
37GSK3 Signaling367.8VEGFC, MST1R, CDH13, CDH1, FIGF, FGF2
38MAPK Family Pathway367.6MET, IL1B, IL6, CCL27, TNF, CTGF
39Colorectal Cancer Metastasis367.6PTGS2, CTNNB1, EGF, EGFR, TLR2, TLR4
40Estrogen Pathway367.6EGFR, TIMP1, TIMP2, TIMP3, TGFB1, HGF
41Cellular Apoptosis Pathway367.5VEGFC, BCL2, CDKN2A, FIGF, FGF2, MET
42PAK Pathway367.4VEGFC, MYH7B, PAK4, BCL2, FIGF, FGF2
43Antioxidant Action of Vitamin-C367.4VEGFC, MYH7B, BCL2, FIGF, FGF2, MET
44Tec Kinases Signaling367.3BCL2, HGF, CXCR4, TGFB1, FIGF, FGF2
45Cytokine-cytokine receptor interaction207.2TGFB1, CCR5, EGFR, TNF, TGFBR2, CXCR4
46Pancreatic Adenocarcinoma367.2FIGF, FGF2, MET, IL6, CCND1, ERBB2
47Molecular Mechanisms of Cancer367.2CDH1, FGF2, MET, IL6, APC, CCL27
48MAPK Signaling367.2HGF, TGFB1, TIMP3, TIMP2, TIMP1, EGFR
49p38 Signaling366.6TP53, HGF, CSF3, CXCR4, TNF, CTGF
50Pathways in cancer206.4RASSF1, RARB, VEGFC, VEGFA, BCL2, PIK3CA

Compounds for genes affiliated with Gallbladder Cancer

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32Novoseek , 42Tocris Bioscience, 9DrugBank, 34PharmGKB, 18HMDB
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Compounds related to gallbladder cancer according to GeneDecks:

(show top 50)    (show all 436)
idCompoundScoreTop Affiliating Genes
1egcg32 10.7NFE2L2, TIMP1, TIMP2
2h2o232 10.5KEAP1, IL1RN, APOB, ESR2, NFE2L2, TLR4
3threonine32 10.5PAK4, MUC2, CDKN1B, CASP8, AFP
4sp 60012532 42 11.1MMP1, MMP13, CASP3, TP53, CTGF, TLR2
5dmso32 10.1APOB, TP73, CR1, THBS1, OGG1, CXCR4
6melphalan32 9 9 11.9MMP2, MGMT, GSTP1, CASP8, ERCC2, ERCC1
7bleomycin32 9 9 11.7XRCC1, CD44, GSTM1, GSTP1, FGF2, TP53
8sodium bisulfite32 9.5RARB, RASSF1, CDKN2A, CDH1, MLH1, MGMT
9rapamycin32 42 10.3VEGFA, CDK4, MET, CCR5, HRAS, SST
10leucovorin32 34 9 9 12.2VEGFA, CEACAM5, CEACAM3, ERBB2, KRAS, EGFR
11sulindac32 9 9 11.1PCNA, BCL2, CDH1, MLH1, APC, CCND1
12ns 39832 42 10.1PCNA, CDKN1B, MMP1, FGF2, IL1B, TNF
13cetuximab32 34 9 9 12.0CDKN1B, ERBB2, ERCC1, PTEN, KRAS, EGF
14tetracycline32 9 9 11.0CDKN2A, MMP1, MMP13, MMP14, MMP2, MMP9
15bromodeoxyuridine32 8.9PIK3CA, NCAM1, PCNA, CDKN1B, CDK4, CD44
16crcs32 8.8PIK3CA, RASSF1, MUC1, MUC2, CEACAM5, MSH2
17cytochalasin d32 42 9.8CD44, CDH1, MMP1, MMP14, MMP2, MMP9
18heparin32 9 18 9 11.8PIK3CA, LRPAP1, NCAM1, VEGFC, CETP, CDH1
19trastuzumab32 34 9 9 11.7PIK3CA, VEGFC, MUC1, CDKN1B, CDK4, CCND1
20glutamine32 8.5NCAM1, PCNA, XRCC1, CETP, CDKN1B, CDH1
21aspirin32 34 18 10.5PCNA, SERPINB5, MTHFR, CETP, CDK4, CDH1
22ribonucleic acid32 8.4VEGFC, RARB, MUC1, CEACAM5, MMP1, MMP13
23creatinine32 8.3NCAM1, PCNA, MUC1, MTHFR, XRCC1, CEACAM3
24erlotinib32 34 9 9 11.3PIK3CA, VEGFA, CDKN1B, CDH1, CCND1, ERBB2
25simvastatin32 34 42 9 18 9 13.2VEGFA, CETP, MMP9, IL1RN, APOB, CCR5
26n acetylcysteine32 8.0PCNA, CDKN1B, CDKN2A, CDK4, CDH1, MMP1
27cholesterol32 9 18 9 10.9PIK3CA, LRPAP1, NAT2, MUC1, MUC2, MTHFR
28imatinib32 34 9 9 10.9PIK3CA, VEGFA, BCL2, CDKN1B, CASP3, CASP8
29mg 13232 42 8.8PCNA, CDKN1B, CDKN2A, CDH1, IL1B, CCND1
30indole-3-carbinol32 7.8BCL2, CDKN1B, CDK4, CDH1, CCND1, CASP3
31tgf beta132 7.7CDKN1B, CDK4, CDH1, MMP1, MMP13, MMP14
32carboplatin32 34 9 9 10.7VEGFA, BCL2, MTHFR, MSH2, CDK4, CD44
33cyclosporin a32 42 8.5PIK3CA, MTHFR, CETP, CDK4, CD44, MMP1
34pdtc32 7.4PIK3CA, SERPINB5, BCL2, MMP1, MMP2, MMP9
35indomethacin32 9 9 9.3PCNA, CDH1, MMP1, MMP13, IL1B, IL1RN
36troglitazone32 42 9 9 10.3BCL2, CDKN1B, CDK4, CDH1, MMP1, MMP2
37cysteine32 7.3PCNA, NAT2, RARB, MUC1, MUC2, MTHFR
385-aza-2deoxycytidine32 7.0PCNA, SERPINB5, RARB, RASSF1, MUC2, S100A4
39resveratrol32 9 18 9 9.9PIK3CA, PCNA, VEGFA, BCL2, CDKN1B, CDK4
40phosphatidylinositol32 6.8PIK3CA, NCAM1, VEGFC, BCL2, CEACAM5, MST1R
41ly29400232 6.7PIK3CA, VEGFA, MUC2, CDKN1B, CD44, CDH1
42gefitinib32 34 9 9 9.7PIK3CA, VEGFA, CEACAM5, CDKN1B, CDK4, CDH1
43thymidine32 18 7.1PIK3CA, PCNA, VEGFC, RARB, MUC1, MTHFR
44doxorubicin32 34 9 9 9.0PIK3CA, NCAM1, CEACAM5, CEACAM3, MSH2, CDKN1B
45curcumin32 5.7VEGFA, BCL2, CDK4, CDH1, MMP1, MMP13
46methotrexate32 34 42 9 9 9.7PCNA, NAT2, MUC1, MUC2, MTHFR, CEACAM3
47progesterone32 42 9 18 9 9.5PIK3CA, NCAM1, PCNA, SERPINB5, VEGFC, RARB
48vegf32 5.1PIK3CA, NCAM1, PCNA, SERPINB5, VEGFC, BCL2
49testosterone32 9 18 9 8.0PIK3CA, NCAM1, PCNA, SERPINB5, VEGFC, RARB
50paclitaxel32 34 9 9 6.9PIK3CA, PCNA, VEGFA, BCL2, CDKN1B, CDKN2A

GO Terms for genes affiliated with Gallbladder Cancer

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12Gene Ontology
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Cellular components related to gallbladder cancer according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.5HGF, TGFB1, THBS1, TIMP1, EGF, FIGF
2external side of plasma membraneGO:0098979.3CXCR4, TGFBR2, THBS1, TLR4, TLR2, TNF
3cell surfaceGO:0099868.4PLAUR, ABCB1, TLR2, TIMP2, TGFB1, CXCR4
4nucleoplasmGO:0056547.7ERCC2, ERCC1, TP53, TYMS, TOP2A, OGG1
5extracellular regionGO:0055767.3CTGF, SST, ESR2, HPSE, ICOS, PLAUR
6extracellular spaceGO:0056155.9AFP, APOB, CCL27, TNF, SST, CTGF
7nucleusGO:0056345.3TP53, TRO, ERCC1, ERBB2, ERCC2, ESR2
8cytoplasmGO:0057375.0KRT20, NFE2L2, CTNNB1, PTGS2, PTEN, TP53
9plasma membraneGO:0058864.7EGF, KRAS, PDPN, NFE2L2, PLAUR, CR1

Biological processes related to gallbladder cancer according to GeneDecks:

(show top 50)    (show all 74)
idNameGO IDScoreTop Affiliating Genes
1activation of MAPKK activityGO:00018610.8NRAS
2extracellular matrix disassemblyGO:02261710.3MMP14, MMP1, MMP13, MMP2, MMP9, TIMP1
3organ regenerationGO:03110010.2AFP, CCKAR, TGFB1, HGF, ANXA3, CCND1
4positive regulation of blood vessel endothelial cell migrationGO:04353610.2TGFB1, VEGFA, VEGFC, FGF2, THBS1
5Ras protein signal transductionGO:00726510.1NRAS, TP53, FGF2, CDKN2A, RASSF1, KRAS
6cell cycle arrestGO:00705010.1RASSF1, MSH2, CDKN1B, HRAS, TP53, APC
7positive regulation of epithelial cell proliferationGO:05067910.0NME1, EGFR, ERBB2, VEGFC, TGFB1, HRAS
8phosphatidylinositol-mediated signalingGO:0480159.9PTEN, TOP2A, ERBB2, CDKN1B, PCNA, TYMS
9fibroblast growth factor receptor signaling pathwayGO:0085439.9PIK3CA, CDKN1B, FGF2, HRAS, PTEN, CTGF
10response to organic cyclic compoundGO:0140709.9TIMP3, CTGF, PTGS2, MET, MSH2, CCND1
11regulation of protein localization to cell surfaceGO:20000089.9CDH1, CTNNB1, EGF
12positive regulation of cell divisionGO:0517819.8APC, IL1B, VEGFC, TGFB1, VEGFA, FGF2
13response to radiationGO:0093149.7BCL2, MMP9, TGFB1, CCKAR, OGG1
14platelet degranulationGO:0025769.7EGF, TIMP1, THBS1, TGFB1, FIGF, VEGFC
15extracellular matrix organizationGO:0301989.6MMP1, MMP13, MMP14, MMP2, MMP9, TNF
16cellular response to organic substanceGO:0713109.6BCL2, IL1B, CASP3, TIMP2, TIMP3
17negative regulation of cell growthGO:0303089.6FGF2, CDKN1B, TGFB1, TRO, TP53, CDKN2A
18induction of apoptosis by intracellular signalsGO:0086299.6HRAS, TP53, NMT1, BCL2, CASP3, CASP8
19positive regulation of protein kinase B signaling cascadeGO:0518979.6THBS1, EGFR, TGFB1, MST1R, TNF, HPSE
20cell proliferationGO:0082839.6FIGF, PDPN, FSCN1, TP53, ERCC1, ERCC2
21positive regulation of interleukin-6 productionGO:0327559.5TNF, IL1B, FIGF, IL6, TLR2, TLR4
22lipopolysaccharide-mediated signaling pathwayGO:0316639.5TLR4, TGFB1, TLR2, IL1B, TNF
23response to estrogen stimulusGO:0436279.4TIMP3, CCND1, KRT19, ESR1, GSTM3, BCL2
24cellular response to organic cyclic compoundGO:0714079.4MGMT, TNF, CTNNB1, TGFB1, CDKN1B, IL1B
25protein kinase B signaling cascadeGO:0434919.4TNF, IL1B, PIK3CA, PTEN, TGFB1
26activation of MAPK activityGO:0001879.4HGF, CXCR4, THBS1, TNF, TP73, IL1B
27positive regulation of ERK1 and ERK2 cascadeGO:0703749.3CTGF, TNF, HRAS, IL1B, FGF2, CD44
28induction of apoptosisGO:0069179.2ERCC2, CDKN2A, CDKN1B, TNF, CASP3, PTEN
29platelet activationGO:0301689.2TIMP1, VEGFA, VEGFC, FIGF, THBS1, IL6
30positive regulation of cell migrationGO:0303359.2MMP14, VEGFA, CDH13, PDPN, THBS1, TGFB1
31MAPK cascadeGO:0001659.2IL1B, CCR5, HRAS, TNF, NRAS, KRAS
32response to glucocorticoid stimulusGO:0513849.2IL1RN, ABCB4, PTGS2, TNF, CCKAR, ANXA3
33epidermal growth factor receptor signaling pathwayGO:0071739.1NRAS, CDKN1B, KRAS, PIK3CA, ERBB2, HRAS
34response to DNA damage stimulusGO:0069749.1RASSF1, CASP3, TOP2A, TP53, TP73, BCL2
35angiogenesisGO:0015259.0CTGF, FIGF, PTEN, VEGFC, VEGFA, EGF
36positive regulation of apoptotic processGO:0430659.0TNF, TLR4, TOP2A, CTNNB1, PTGS2, RARB
37response to estradiol stimulusGO:0323559.0CASP8, TGFB1, IL1B, PTGS2, CTGF, CTNNB1
38positive regulation of protein phosphorylationGO:0019348.9VEGFA, IL1B, CCND1, TNF, CTGF, KRAS
39blood coagulationGO:0075968.9VEGFA, PIK3CA, MMP1, VEGFC, APOB, HRAS
40positive regulation of MAP kinase activityGO:0434068.9TNF, EGF, KRAS, ERBB2, MST1R, VEGFA
41positive regulation of peptidyl-serine phosphorylationGO:0331388.8MET, IL6, TNF, CD44, VEGFA, BCL2
42positive regulation of sequence-specific DNA binding transcription factor activityGO:0510918.8ANXA3, PTEN, TNF, ESR2, ESR1, IL6
43positive regulation of nitric oxide biosynthetic processGO:0454298.8TLR2, TLR4, IL1B, ESR1, TNF, PTGS2
44response to hypoxiaGO:0016668.7VEGFA, BCL2, MMP9, TLR4, CXCR4, TGFB1
45positive regulation of cell proliferationGO:0082848.4CDK4, CDKN1B, MST1R, VEGFC, VEGFA, IL6
46apoptotic processGO:0069158.2ERCC2, HRAS, CASP8, CASP3, APC, TP53
47response to drugGO:0424938.1VEGFC, PTGS2, SST, ABCB1, ABCB4, TOP2A
48negative regulation of apoptotic processGO:0430667.9ERCC1, TP53, TNF, CXCR7, THBS1, TIMP1
49positive regulation of transcription from RNA polymerase II promoterGO:0459447.7FGF2, RARB, TP73, TNF, CTNNB1, NFE2L2
50negative regulation of cell proliferationGO:0082857.4CDH13, CDKN2A, CDKN1B, ZEB1, RARB, FGF2

Molecular functions related to gallbladder cancer according to GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1fibronectin bindingGO:0019689.9VEGFA, MMP9, CTGF, THBS1
2chemoattractant activityGO:0420569.7FGF2, FIGF, VEGFC, VEGFA
3protein heterodimerization activityGO:0469828.5ABCG8, TOP2A, TLR2, TGFB1, HGF, EGFR
4growth factor activityGO:0080838.4HGF, CSF3, TGFB1, EGF, CTGF, IL6
5enzyme bindingGO:0198998.2CTNNB1, PLAUR, EGFR, TOP2A, TGFB1, CSF3
6identical protein bindingGO:0428027.9TP53, TP73, TNF, EGFR, THBS1, NME1
7protein bindingGO:0055152.3HGF, KRT20, PLAUR, CTNNB1, PTEN, TNF

Sources for Gallbladder Cancer

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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