GBC
MCID: GLL018
MIFTS: 53

Gallbladder Cancer (GBC) malady

Cancer, Liver categories

Summaries for Gallbladder Cancer

Sources:
8Disease Ontology, 34MedlinePlus, 64Wikipedia, 33MalaCards
See all sources

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MedlinePlus:34 Your gallbladder is a pear-shaped organ under your liver. it stores bile, a fluid made by your liver to digest fat. as your stomach and intestines digest food, your gallbladder releases bile through a tube called the common bile duct. the duct connects your gallbladder and liver to your small intestine. cancer of the gallbladder is rare. it is more common in women and native americans. symptoms include jaundice (yellowing of the skin and whites of the eyes) pain above the stomach fever nausea and vomiting bloating lumps in the abdomen it is hard to diagnose gallbladder cancer in its early stages. sometimes doctors find it when they remove the gallbladder for another reason. but people with gallstones rarely have gallbladder cancer. because it is often found late, it can be hard to treat gallbladder cancer. treatment options include surgery, chemotherapy, radiation, or a combination. nih: national cancer institute

MalaCards: Gallbladder Cancer, also known as gallbladder carcinoma, is related to biliary tract cancer and colorectal cancer, and has symptoms including extrahepatic biliary tract/gallbladder neoplasm/tumor/carcinoma/cancer, acute abdominal pain/colic and anorexia. An important gene associated with Gallbladder Cancer is HPSE (heparanase). The compounds tyrosine and 5-aza-2deoxycytidine have been mentioned in the context of this disorder. Affiliated tissues include the gallbladder, and related mouse phenotypes are digestive/alimentary and endocrine/exocrine gland.

Disease Ontology:8 A biliary tract cancer that is located in the gallbladder.

Wikipedia:64 Gallbladder cancer is a relatively uncommon cancer. It has peculiar geographical distribution being... more...

Aliases & Classifications for Gallbladder Cancer

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 49Orphanet, 34MedlinePlus, 61UMLS, 43NIH Rare Diseases, 57SNOMED-CT, 40NCIt, 35MeSH, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Liver


Characteristics (Orphanet epidemiological data):

49
gallbladder cancer:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Adulthood


Aliases & Descriptions:

gallbladder cancer 8 10 45 49 34
gallbladder carcinoma 8 10 45 61
malignant neoplasm of gallbladder 8 61
gallbladder neoplasm 8 61
malignant neoplasm of gallbladder localized 61
localized malignant gallbladder neoplasm 8
malignant tumor of the gallbladder 8
malignant tumour of gallbladder 8
carcinoma of the gallbladder 49
cancer of the gallbladder 8
tumor of the gallbladder 8
carcinoma of gallbladder 8
carcinoma gallbladder 8
gall bladder cancer 43
gallbladder ca 8
gbc 49


External Ids:

Disease Ontology8 DOID:3121, DOID:4948
NCIt40 C3048, C3844
MeSH35 D005706
ICD10 via Orphanet26 C23
SNOMED-CT via Orphanet58 372140005
UMLS via Orphanet62 C0235782
ICD1025 C23

Related Diseases for Gallbladder Cancer

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Gallbladder Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 153)
idRelated DiseaseScoreTop Affiliating Genes
1biliary tract cancer30.4PSG2, MLH1, DPYD, TYMS, TGFBR2
2colorectal cancer30.2DPYD, TYMS, MUC2, CDX2, CYP7A1, HPSE
3adenocarcinoma30.2CCKAR, APC, PSG2, SNCG, MLH1, DPYD
4papillary carcinoma30.2MUC2, SERPINB5, CEACAM3
5squamous cell carcinoma30.1APC, PSG2, TGFBR2, MLH1, DPYD, TYMS
6carcinoid syndrome30.1CDX2, CEACAM3, CEACAM5
7adenoma30.0APC, PSG2, MLH1, MUC2, CDX2, SERPINB5
8thyroid cancer30.0CCKAR, APC, SERPINB5
9cholelithiasis30.0CYP7A1, PSG2
10oral cancer30.0GSTM3
11neuroendocrine carcinoma10.7
12spindle cell carcinoma10.6
13adenosquamous carcinoma10.6
14xanthogranulomatous cholecystitis10.6
15large cell carcinoma10.5
16pleomorphic carcinoma10.4
17vascular cancer10.3
18gastrointestinal stromal tumor10.3
19bacteremia10.2
20abdominal aortic aneurysm10.1
21aortic aneurysm10.1
22tuberculosis10.1
23mirizzi syndrome10.1
24adenosquamous gallbladder carcinoma10.1
25hypoxia10.1
26ileus10.1
27bullous pemphigoid10.1
28acute pancreatitis10.1
29gallbladder signet ring cell adenocarcinoma10.1
30cushing's syndrome10.1
31cribriform carcinoma10.1
32necrotizing fasciitis10.1
33spindle cell sarcoma10.1
34ulcerative colitis10.1
35biliary dyskinesia10.1
36clonorchiasis10.1
37bile duct disease10.1
38primary sclerosing cholangitis10.1
39neuropathy, paraneoplastic sensory10.1
40keratinizing squamous cell carcinoma10.1
41granular cell tumor10.1
42gallbladder squamous cell carcinoma10.1
43gallbladder mucinous carcinoma10.1
44rhabdoid tumor10.1
45vascular disease10.1
46yellow nail syndrome10.0
47sclerosing cholangitis10.0
48klatskin's tumor10.0
49n syndrome10.0
50breast cancer10.0APC, PSG2, SNCG, MLH1, DPYD, TYMS

Graphical network of the top 20 diseases related to Gallbladder Cancer:



Diseases related to gallbladder cancer

Clinical Features for Gallbladder Cancer

Sources:
49Orphanet
See all sources


Symptoms:

49 (show all 6)
  • extrahepatic biliary tract/gallbladder neoplasm/tumor/carcinoma/cancer
  • acute abdominal pain/colic
  • anorexia
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • hepatitis/icterus/cholestasis
  • lymphadenopathy/polyadenopathies

Drugs & Therapeutics for Gallbladder Cancer

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Gallbladder Cancer

Drug clinical trials:

Search ClinicalTrials for Gallbladder Cancer

Search NIH Clinical Center for Gallbladder Cancer

Search CenterWatch for Gallbladder Cancer

Genetic Tests for Gallbladder Cancer

Anatomical Context for Gallbladder Cancer

Sources:
14FMA
See all sources

FMA organs/tissues related to Gallbladder Cancer:

14
The gallbladder

Animal Models for Gallbladder Cancer or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Gallbladder Cancer:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538110.6APC, MLH1, MUC2, CDX2, CYP7A1, TGFBR2
2MP:000537910.3MST1R, HPSE, CDX2, MUC2, MLH1, CCKAR

Publications for Gallbladder Cancer

Sources:
51PubMed
See all sources

Articles related to Gallbladder Cancer:

(show top 50)    (show all 541)
idTitleAuthorsYear
1
Letter Re: Gallbladder cancer involving the extrahepatic bile duct is worthy of resection. (23728286)
2013
2
Predictors of incidental gallbladder cancer in patients undergoing cholecystectomy for benign gallbladder disease. (22886779)
2013
3
Association of liver X receptors (LXRs) genetic variants to gallbladder cancer susceptibility. (23838803)
2013
4
Regional differences in gallbladder cancer pathogenesis: insights from a comparison of cell cycle-regulatory, PI3K, and pro-angiogenic protein expression. (23212762)
2013
5
Key factors influencing prognosis in relation to gallbladder cancer. (23695876)
2013
6
Gallbladder cancer management impacted by coexistent tuberculosis. (24377155)
2013
7
Unexpected gallbladder cancer after laparoscopic cholecystectomy for acute cholecystitis: a worrisome picture. (22653330)
2012
8
Guggulsterone enhances antitumor activity of gemcitabine in gallbladder cancer cells through suppression of NF-I_B. (22699931)
2012
9
Incidentally detected gallbladder cancer- the controversies and algorithmic approach to management. (23730052)
2012
10
Incidental gallbladder cancer diagnosed during or after laparoscopic cholecystectomy in members of the Turkish population with gallstone disease. (22234759)
2011
11
Optimal surgical treatment for patients with pT2 gallbladder cancer. (21510279)
2011
12
Mutagenicity and mutagens of the red chili pepper as gallbladder cancer risk factor in Chilean women. (21545215)
2011
13
Candidate gene studies in gallbladder cancer: a systematic review and meta-analysis. (21708280)
2011
14
Outcomes of radical surgery for gallbladder cancer patients with lymphatic metastases. (21712255)
2011
15
A rare case of gallbladder cancer with giardiasis]. (21307633)
2011
16
The role of laparoscopic staging in patients with incidental gallbladder cancer. (21689230)
2011
17
Gallbladder cancer: incidence and survival in a high-risk area of Chile. (20473911)
2010
18
Laparoscopic radical cholecystectomy and Roux-en-Y choledochojejunostomy for gallbladder cancer. (20054570)
2010
19
Lymphatic invasion: an important prognostic factor for stages T1b-T3 gallbladder cancer and an indication for additional radical resection of incidental gallbladder cancer. (19225832)
2009
20
Gallbladder cancer. (18466866)
2008
21
Prediction model for adjuvant radiation therapy for gallbladder cancer: not ready to be used. (18802171)
2008
22
Port site and distant metastases of gallbladder cancer after laparoscopic cholecystectomy diagnosed by positron emission tomography. (19009666)
2008
23
Ten-year experience in the management of gallbladder cancer from a single hepatobiliary and pancreatic centre with review of the literature. (19088932)
2008
24
Resection of gallbladder cancer with hepatic metastasis after chemotherapy with gemcitabine. (18987939)
2008
25
Somatostatin elevates topoisomerase II alpha and enhances the cytotoxic effect of doxorubicin on gallbladder cancer cells. (18824850)
2008
26
Defining the completeness of surgery for early gallbladder cancer. (18948823)
2008
27
Successful treatment of advanced gallbladder cancer with an anticancer drug S-1: assessment based on intratumoral gene. (19093184)
2008
28
Endoscopic or percutaneous biliary drainage for gallbladder cancer: a randomized trial and quality of life assessment. (18585976)
2008
29
Incidence pattern and survival for gallbladder cancer over three decades--an analysis of 10301 patients. (17109082)
2007
30
International comparisons of cumulative risk of gallbladder cancer and other biliary tract cancer, from Cancer Incidence in Five Continents Vol. VIII. (17272323)
2007
31
CA 125: a potential tumor marker for gallbladder cancer. (16724349)
2006
32
Preliminary study of p53 and c-erbB-2 expression in gallbladder cancer in Indian patients manuscript id: 8962091628764582. (16686942)
2006
33
Evidence-based gallbladder cancer staging: changing cancer staging by analysis of data from the National Cancer Database. (16772780)
2006
34
Prognostic significance of the number of positive lymph nodes in gallbladder cancer. (16843870)
2006
35
Gallbladder cancer worldwide: geographical distribution and risk factors. (16397865)
2006
36
The role of gemcitabine in the treatment of cholangiocarcinoma and gallbladder cancer: a systematic review. (16341310)
2005
37
Detection of bone marrow micrometastases in patients with gallbladder cancer]. (15743160)
2004
38
Clinical relationship between MDR1 gene and gallbladder cancer. (15138130)
2004
39
A MEK inhibitor (U0126) markedly inhibits direct liver invasion of orthotopically inoculated human gallbladder cancer cells in nude mice. (15743030)
2004
40
A new method to establish the rational extent of hepatic resection for advanced gallbladder cancer using dye injection through the cystic artery. (18333043)
2004
41
Abnormal arrangement of the pancreato-biliary ductal system associated with advanced gallbladder cancer diagnosed 3 years after follow-up ultrasonography. (14673731)
2003
42
A 10-year experience in the management of gallbladder cancer. (18332977)
2003
43
Gallbladder cancer invading the perimuscular connective tissue: results of reresection after prior non-curative operation. (12884232)
2003
44
Genetic analysis of xanthogranulomatous cholecystitis: precancerous lesion of gallbladder cancer? (12143246)
2002
45
Genetic polymorphisms of cytochrome P450 1A1 and risk of gallbladder cancer. (12071517)
2002
46
Prognostic significance of S100A4 expression in gallbladder cancer. (11956586)
2002
47
Association of p53, p16, and vascular endothelial growth factor protein expressions with the prognosis and metastasis of gallbladder cancer. (11584965)
2001
48
Xanthogranulomatous cholecystitis mimicking gallbladder cancer: report of a case. (11830932)
2001
49
An immunohistochemical and molecular biological study of c-erbB-2 amplification and prognostic relevance in gallbladder cancer. (8101375)
1993
50
Gallbladder disease and gallbladder cancer among American Indians in tricultural New Mexico. (719624)
1978

Genetic Variations for Gallbladder Cancer

Expression for genes affiliated with Gallbladder Cancer

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Gallbladder Cancer

Search GEO for disease gene expression data for Gallbladder Cancer.

Pathways for genes affiliated with Gallbladder Cancer

Compounds for genes affiliated with Gallbladder Cancer

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB
See all sources

Compounds related to Gallbladder Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1tyrosine4511.1TRO, MLH1, SNCG, APC, CCKAR, DPYD
25-aza-2deoxycytidine4511.1TGFBR2, APC, SNCG, MLH1, DPYD, MUC2
3progesterone45 60 29 11 2415.1APC, MLH1, DPYD, MUC2, CDX2, CYP7A1
4paraffin4511.1APC, PSG2, MLH1, DPYD, MUC2, CDX2
5vegf4511.1PSG2, MLH1, DPYD, TYMS, HPSE, IL32
6calcium45 50 11 2414.1CCKAR, CCL27, APC, SNCG, MLH1, MUC2
7glucose4511.0CCKAR, APC, PSG2, MUC2, CYP7A1, HPSE
8crcs4511.0APC, MLH1, DPYD, MUC2, CEACAM5, TGFBR2
95fluorouracil4511.0PSG2, MLH1, DPYD, TYMS, MUC2, CEACAM3
10thymidine45 2412.0PSG2, MLH1, DPYD, TYMS, CDX2, CEACAM3
11cytosine45 2412.0APC, PSG2, MLH1, SERPINB5, CEACAM3, CEACAM5
12leucovorin45 50 1113.0PSG2, DPYD, TYMS, CEACAM3, CEACAM5
13irinotecan45 50 1113.0MLH1, DPYD, TYMS, CEACAM3, CEACAM5
145-fluorocytosine4511.0PSG2, TYMS, CEACAM3, CEACAM5
15cholesterol45 29 11 2414.0CCKAR, CCL27, MUC2, CYP7A1, CEACAM3, CEACAM5
16lipid4511.0CCKAR, CCL27, APC, PSG2, CYP7A1, HPSE
17estrogen4511.0CYP7A1, SNCG
18idurd4511.0MLH1, DPYD, TYMS
19oxaliplatin45 50 1112.9MLH1, DPYD, TYMS, CEACAM5
20cisplatin45 50 60 1113.9MLH1, DPYD, TYMS, SERPINB5, CEACAM5, GSTM3
21hematoxylin4510.9PSG2, MUC2, CEACAM3, CEACAM5
225-deoxy-5-fluorouridine4510.9DPYD, TYMS, CEACAM5
23steroid4510.9CEACAM3, SERPINB5, CYP7A1, CDX2
2418f fluorodeoxyglucose4510.9PSG2, CEACAM3, CEACAM5
25gemcitabine45 50 1112.9MLH1, DPYD, TYMS, HPSE
26mononucleotide4510.9APC, MLH1, TGFBR2
27tamoxifen45 50 29 1113.9TYMS, HPSE, SERPINB5, CEACAM3, TGFBR2
28metronidazole45 1111.9CEACAM5, CEACAM3, PSG2
29polynucleotide4510.9TGFBR2, CEACAM5, CEACAM3
30fudr4510.9TYMS, DPYD, PSG2
31thymidylate4510.9CEACAM3, TYMS, DPYD, MLH1
32tegafur-uracil4510.8DPYD, TYMS
33sn 3845 6011.8MLH1, DPYD, TYMS
34p0024510.8PSG2, MLH1, SERPINB5, CEACAM5
35sulfate45 2411.8CCKAR, MUC2, HPSE, GSTM3
36eniluracil4510.8DPYD, TYMS
37adriamycin4510.8CEACAM5, CEACAM3, TYMS, PSG2
38deoxycholic acid45 29 11 2413.8CYP7A1, CDX2, MUC2
39b 7234510.8PSG2, CEACAM3, CEACAM5
40sialic acid4510.7CEACAM5, CEACAM3
41doxorubicin45 50 1112.7CEACAM5, CEACAM3, TYMS, MLH1, PSG2
42pyrimidine analogues5010.7DPYD, TYMS
432-deoxyuridine-5-monophosphate4510.7DPYD, TYMS
44oligonucleotide4510.7APC, DPYD, MUC2, CDX2, HPSE, TGFBR2
45agarose4510.7MLH1, MUC2, HPSE, TGFBR2
46folate4510.6APC, MLH1, DPYD, TYMS
47methotrexate45 50 1112.5CEACAM3, MUC2, TYMS, DPYD
485-fluoro-2-deoxyuridine-5-monophosphate4510.5DPYD, TYMS
49bvdu4510.4DPYD, TYMS
50indium4510.2PSG2, CEACAM3

GO Terms for genes affiliated with Gallbladder Cancer

Products for genes affiliated with Gallbladder Cancer

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gallbladder Cancer

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet