GBC
MCID: GLL018
MIFTS: 64

Gallbladder Cancer (GBC) malady

Cancer diseases, Liver diseases, Nephrological diseases categories

Summaries for Gallbladder Cancer

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Sources:
8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Your gallbladder is a pear-shaped organ under your liver. it stores bile, a fluid made by your liver to digest fat. as your stomach and intestines digest food, your gallbladder releases bile through a tube called the common bile duct. the duct connects your gallbladder and liver to your small intestine. cancer of the gallbladder is rare. it is more common in women and native americans. symptoms include jaundice (yellowing of the skin and whites of the eyes) pain above the stomach fever nausea and vomiting bloating lumps in the abdomen it is hard to diagnose gallbladder cancer in its early stages. sometimes doctors find it when they remove the gallbladder for another reason. but people with gallstones rarely have gallbladder cancer. because it is often found late, it can be hard to treat gallbladder cancer. treatment options include surgery, chemotherapy, radiation, or a combination. nih: national cancer institute

MalaCards: Gallbladder Cancer, also known as gallbladder carcinoma, is related to gallbladder disease and cholangiocarcinoma, and has symptoms including acute abdominal pain/colic, anorexia and nausea/vomiting/regurgitation/merycism/hyperemesis. An important gene associated with Gallbladder Cancer is HPSE (heparanase). The compounds tyrosine and 5-aza-2deoxycytidine have been mentioned in the context of this disorder. Affiliated tissues include the gallbladder, liver and lymph node, and related mouse phenotypes are digestive/alimentary and endocrine/exocrine gland.

Disease Ontology:8 A biliary tract cancer that is located in the gallbladder.

Wikipedia:63 Gallbladder cancer is a relatively uncommon cancer. It has peculiar geographical distribution being... more...

Aliases & Classifications for Gallbladder Cancer

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Liver diseases, Nephrological diseases


Characteristics (Orphanet epidemiological data):

48
gallbladder cancer:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Adulthood


Aliases & Descriptions:

gallbladder cancer 8 10 44 48 33
gallbladder carcinoma 8 10 44 60
malignant neoplasm of gallbladder 8 60
gallbladder neoplasm 8 60
malignant neoplasm of gallbladder localized 60
localized malignant gallbladder neoplasm 8
malignant tumor of the gallbladder 8
malignant tumour of gallbladder 8
carcinoma of the gallbladder 48
cancer of the gallbladder 8
tumor of the gallbladder 8
carcinoma of gallbladder 8
carcinoma gallbladder 8
gall bladder cancer 42
gallbladder ca 8
gbc 48


External Ids:

Disease Ontology8 DOID:3121, DOID:4948
NCIt39 C3048, C3844
MeSH34 D005706
ICD10 via Orphanet26 C23
SNOMED-CT via Orphanet57 372140005
UMLS via Orphanet61 C0235782
ICD1025 C23

Related Diseases for Gallbladder Cancer

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Gallbladder Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 171)
idRelated DiseaseScoreTop Affiliating Genes
1gallbladder disease30.8CCKAR, MUC2
2cholangiocarcinoma30.7PSG2, MUC2, CDX2, CEACAM3, CEACAM5
3hepatitis30.6CCL27
4pancreatic cancer30.3CCKAR, DPYD, MUC2, CDX2, IL32, SERPINB5
5pancreatitis30.3CCKAR
6neuroendocrine tumor30.3PSG2, CDX2, CEACAM3
7colorectal cancer30.1DPYD, TYMS, MUC2, CDX2, CYP7A1, HPSE
8adenocarcinoma30.1CCKAR, APC, PSG2, SNCG, MLH1, DPYD
9lung cancer30.1PSG2, TYMS, CDX2, CEACAM3, CEACAM5, TGFBR2
10sarcoma30.1SERPINB5, MLH1
11papillary carcinoma30.1MUC2, SERPINB5, CEACAM3
12squamous cell carcinoma30.1APC, PSG2, TGFBR2, MLH1, DPYD, TYMS
13hepatocellular carcinoma29.9MUC2, DPYD, PSG2, APC, CDX2, HPSE
14retinoblastoma29.9TGFBR2, TYMS, SNCG, APC
15colon cancer29.9TGFBR2, APC, PSG2, MLH1, DPYD, TYMS
16adenoma29.9APC, PSG2, MLH1, MUC2, CDX2, SERPINB5
17melanoma29.9PSG2, MLH1, CDX2, HPSE, SERPINB5, CEACAM3
18thyroid cancer29.9CCKAR, APC, SERPINB5
19cholelithiasis29.9CYP7A1, PSG2
20prostate cancer29.9TGFBR2, CEACAM3, SERPINB5, HPSE, CDX2
21neuroendocrine carcinoma10.6
22cholecystitis10.6
23spindle cell carcinoma10.6
24adenosquamous carcinoma10.6
25lymph node cancer10.5
26xanthogranulomatous cholecystitis10.5
27large cell carcinoma10.5
28pleomorphic carcinoma10.4
29vascular cancer10.3
30hepatitis a10.2
31connective tissue cancer10.2
32in situ carcinoma10.2
33gastrointestinal stromal tumor10.2
34von hippel-lindau disease10.2
35duodenitis10.2
36gall-bladder endocrine tumor10.2
37adenosquamous gallbladder carcinoma10.1
38abdominal aortic aneurysm10.1
39aortic aneurysm10.1
40gallbladder adenocarcinoma10.1
41obesity10.1
42tuberculosis10.1
43bullous pemphigoid10.1
44acute pancreatitis10.1
45gallbladder signet ring cell adenocarcinoma10.1
46cushing's syndrome10.1
47cribriform carcinoma10.1
48necrotizing fasciitis10.1
49spindle cell sarcoma10.1
50ulcerative colitis10.1

Graphical network of the top 20 diseases related to Gallbladder Cancer:



Diseases related to gallbladder cancer

Clinical Features for Gallbladder Cancer

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Sources:
48Orphanet
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Symptoms:

48
  • acute abdominal pain/colic
  • anorexia
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • hepatitis/icterus/cholestasis
  • lymphadenopathy/polyadenopathies
  • extrahepatic biliary tract/gallbladder neoplasm/tumor/carcinoma/cancer

Drugs & Therapeutics for Gallbladder Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Gallbladder Cancer

Drug clinical trials:

Search ClinicalTrials for Gallbladder Cancer

Search NIH Clinical Center for Gallbladder Cancer

Search CenterWatch for Gallbladder Cancer

Genetic Tests for Gallbladder Cancer

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Anatomical Context for Gallbladder Cancer

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Gallbladder Cancer:

32
Liver, Lymph node, Skin, Eye, Small intestine, Endothelial, Lung, Colon, Pancreas, Testes, Bone, Prostate, Bone marrow, Breast, Thyroid

FMA organs/tissues related to Gallbladder Cancer:

14
The gallbladder

Animal Models for Gallbladder Cancer or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Gallbladder Cancer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538110.6APC, MLH1, MUC2, CDX2, CYP7A1, TGFBR2
2MP:000537910.3MST1R, HPSE, CDX2, MUC2, MLH1, CCKAR

Publications for Gallbladder Cancer

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Sources:
50PubMed
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Articles related to Gallbladder Cancer:

(show top 50)    (show all 541)
idTitleAuthorsYear
1
Reply to Letter Re: "Gallbladder cancer involving the extrahepatic bile duct is worthy of resection". (23728287)
2013
2
An often overlooked diagnosis: imaging features of gallbladder cancer. (23195201)
2013
3
Anticancer activity of oncolytic adenoviruses carrying p53 is augmented by 11R in gallbladder cancer cell lines in vitro and in vivo. (23727990)
2013
4
PKM2 and ACVR 1C are prognostic markers for poor prognosis of gallbladder cancer. (23793810)
2013
5
Restoration of deleted in liver cancer 1 gene expression inhibits gallbladder cancer growth through induction of cell cycle arrest and apoptosis. (24329682)
2013
6
Analysis of the relationships between clinicopathologic factors and survival in gallbladder cancer following surgical resection with curative intent. (23300551)
2012
7
Successful treatment of unresectable gallbladder cancer with low-dose paclitaxel as palliative chemotherapy after failure of gemcitabine and oral S-1: A case report. (23226802)
2012
8
Postoperative chemoradiotherapy for gallbladder cancer. (22402869)
2012
9
Advanced gallbladder cancer misdiagnosis. (22534018)
2012
10
Risk factors for gallbladder cancer and cholangiocarcinoma: similarities, differences and updates. (21597894)
2012
11
Gallbladder cancer involving the extrahepatic bile duct. (22566023)
2012
12
Aflatoxin contamination of red chili pepper from Bolivia and Peru, countries with high gallbladder cancer incidence rates. (23244129)
2012
13
The prognosis after curative resection of gallbladder cancer with hilar invasion is similar to that of hilar cholangiocarcinoma. (21879321)
2012
14
Revision surgery for incidentally detected early gallbladder cancer in laparoscopic era. (21612445)
2011
15
Muscle metastases from gallbladder cancer. (22276068)
2011
16
Side population cells in human gallbladder cancer cell line GBC-SD regulated by TGF-I^-induced epithelial-mesenchymal transition. (22173493)
2011
17
Emodin potentiates the anticancer effect of cisplatin on gallbladder cancer cells through the generation of reactive oxygen species and the inhibition of survivin expression. (21769433)
2011
18
Comparison of thymidine phosphorylase expression and prognostic factors in gallbladder and bile duct cancer. (20955617)
2010
19
Comparison of time trends in gallbladder cancer mortality (1990-2006) between countries based using the WHO mortality database. (20360421)
2010
20
Common genetic variants in pre-microRNAs and risk of gallbladder cancer in North Indian population. (20520619)
2010
21
Is laparoscopic surgery for early gallbladder cancer less invasive or dangerous? (20713939)
2010
22
Vascular endothelial growth factor-C promotes the growth and invasion of gallbladder cancer via an autocrine mechanism. (20734221)
2010
23
Evolving treatment strategies for gallbladder cancer. (19495882)
2009
24
Expression and clinical significance of cell cycle regulatory proteins in gallbladder and extrahepatic bile duct cancer. (18979138)
2009
25
Gallbladder cancer: the role of laparoscopy and radical resection. (19730180)
2009
26
E1A, E1B double-restricted replicative adenovirus at low dose greatly augments tumor-specific suicide gene therapy for gallbladder cancer. (18818710)
2009
27
Gallbladder cancer: the basics. (21960896)
2008
28
Gallbladder cancer incidence among American Indians and Alaska Natives, US, 1999-2004. (18720382)
2008
29
Extended hepatic resection for gallbladder cancer. (17693282)
2007
30
Amyloidosis of the gallbladder mimicking gallbladder cancer. (17380287)
2007
31
Obesity and the risk of gallbladder cancer: a meta-analysis. (17375043)
2007
32
Gallbladder cancer: Defining the indications for primary radical resection and radical re-resection. (17103074)
2007
33
Radical lymph node dissection for gallbladder cancer: indications and limitations. (17336245)
2007
34
Gallbladder cancer. (16724359)
2006
35
Correlation of nutritional parameters of gallbladder cancer patients. (16724358)
2006
36
Extrahepatic bile duct resection: standard treatment for advanced gallbladder cancer? (16941527)
2006
37
Gallbladder reefing for cholelithiasis as a complication of colon cancer. (15782992)
2005
38
Cisplatin represses transcriptional activity from the minimal promoter of the O6-methylguanine methyltransferase gene and increases sensitivity of human gallbladder cancer cells to 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-2-chloroethyl)-3-nitrosourea. (15809756)
2005
39
Gallbladder cancer: what is an aggressive approach? (15729061)
2005
40
Gallbladder cancer and liver transplantation. (15612984)
2005
41
Laparoscopic staging in gallbladder cancer. (16479113)
2005
42
Gallbladder cancer treatment using adenovirus expressing the HGF/NK4 gene in a peritoneal implantation model. (15118756)
2004
43
Treatment outcomes associated with surgery for gallbladder cancer: a 20-year experience. (15036194)
2004
44
Protection of trocar sites from gallbladder cancer implantation in a murine model by physically covering the sites. (15730100)
2004
45
Acute cholecystitis with a hemocholecyst as an unusual presentation of gallbladder cancer: report of a case. (15526137)
2004
46
Bowel movement frequency, medical history and the risk of gallbladder cancer death: a cohort study in Japan. (15298731)
2004
47
Gallbladder cancer: an 'Indian' disease. (14606770)
2003
48
Xanthogranulomatous cholecystitis mimicking stage IV gallbladder cancer. (14571712)
2003
49
Epidemiology of gallbladder cancer and trends in cholecystectomy rates in Scotland, 1968-1998. (12957463)
2003
50
nm23-H1 protein immunoreactivity in cancers of the gallbladder, extrahepatic bile ducts and ampulla of Vater. (7892048)
1994

Genetic Variations for Gallbladder Cancer

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Expression for genes affiliated with Gallbladder Cancer

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gallbladder Cancer

Search GEO for disease gene expression data for Gallbladder Cancer.

Pathways for genes affiliated with Gallbladder Cancer

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Compounds for genes affiliated with Gallbladder Cancer

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Gallbladder Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1tyrosine4411.1DPYD, CEACAM5, TRO, CYP7A1, IL32, MST1R
25-aza-2deoxycytidine4411.1CDX2, MLH1, HPSE, APC, TGFBR2, SNCG
3progesterone44 59 28 11 2415.1CYP7A1, MUC2, DPYD, MLH1, APC, TGFBR2
4paraffin4411.1CEACAM5, SERPINB5, APC, MUC2, CEACAM3, DPYD
5vegf4411.1PSG2, MLH1, DPYD, TYMS, HPSE, IL32
6calcium44 49 11 2414.1TGFBR2, HPSE, MUC2, CDX2, MLH1, SNCG
7glucose4411.0TGFBR2, CEACAM5, CEACAM3, HPSE, CYP7A1, PSG2
8crcs4411.0CEACAM5, TGFBR2, APC, MLH1, DPYD, MUC2
95fluorouracil4411.0MLH1, TYMS, DPYD, PSG2, CEACAM5, CEACAM3
10thymidine44 2412.0CEACAM3, DPYD, MLH1, PSG2, CDX2, TYMS
11cytosine44 2412.0PSG2, APC, MLH1, SERPINB5, CEACAM3, CEACAM5
12leucovorin44 49 1113.0PSG2, CEACAM3, CEACAM5, TYMS, DPYD
13irinotecan44 49 1113.0CEACAM5, MLH1, DPYD, TYMS, CEACAM3
145-fluorocytosine4411.0TYMS, PSG2, CEACAM3, CEACAM5
15cholesterol44 28 11 2414.0CEACAM5, MUC2, CCKAR, CCL27, CYP7A1, CEACAM3
16lipid4411.0CCL27, PSG2, CYP7A1, APC, CEACAM5, CCKAR
17estrogen4411.0SNCG, CYP7A1
18idurd4411.0MLH1, DPYD, TYMS
19oxaliplatin44 49 1112.9MLH1, DPYD, CEACAM5, TYMS
20cisplatin44 49 59 1113.9DPYD, CEACAM5, SERPINB5, GSTM3, TYMS, MLH1
21hematoxylin4410.9MUC2, PSG2, CEACAM3, CEACAM5
225-deoxy-5-fluorouridine4410.9CEACAM5, TYMS, DPYD
23steroid4410.9CEACAM3, CDX2, CYP7A1, SERPINB5
2418f fluorodeoxyglucose4410.9CEACAM3, CEACAM5, PSG2
25gemcitabine44 49 1112.9TYMS, HPSE, DPYD, MLH1
26mononucleotide4410.9APC, TGFBR2, MLH1
27tamoxifen44 49 28 1113.9TGFBR2, HPSE, SERPINB5, CEACAM3, TYMS
28metronidazole44 1111.9PSG2, CEACAM5, CEACAM3
29polynucleotide4410.9TGFBR2, CEACAM3, CEACAM5
30fudr4410.9PSG2, DPYD, TYMS
31thymidylate4410.9MLH1, CEACAM3, DPYD, TYMS
32eniluracil4410.8TYMS, DPYD
33sn 3844 5911.8MLH1, TYMS, DPYD
34p0024410.8MLH1, SERPINB5, CEACAM5, PSG2
35sulfate44 2411.8HPSE, CCKAR, MUC2, GSTM3
36tegafur-uracil4410.8TYMS, DPYD
37adriamycin4410.8CEACAM5, TYMS, PSG2, CEACAM3
38deoxycholic acid44 28 11 2413.8CYP7A1, MUC2, CDX2
39b 7234410.8CEACAM5, PSG2, CEACAM3
40sialic acid4410.7CEACAM3, CEACAM5
41doxorubicin44 49 1112.7TYMS, MLH1, PSG2, CEACAM3, CEACAM5
422-deoxyuridine-5-monophosphate4410.7TYMS, DPYD
43pyrimidine analogues4910.7DPYD, TYMS
44oligonucleotide4410.7TGFBR2, DPYD, APC, CDX2, MUC2, HPSE
45agarose4410.7MLH1, MUC2, HPSE, TGFBR2
46folate4410.6TYMS, APC, MLH1, DPYD
47methotrexate44 49 1112.5MUC2, DPYD, TYMS, CEACAM3
485-fluoro-2-deoxyuridine-5-monophosphate4410.5DPYD, TYMS
49indium4410.4PSG2, CEACAM3
50bvdu4410.2DPYD, TYMS

GO Terms for genes affiliated with Gallbladder Cancer

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Products for genes affiliated with Gallbladder Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gallbladder Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet