Gallbladder Carcinoma malady

MedlinePlus: Your gallbladder is a pear-shaped organ under your liver. it stores bile, a fluid made by your liver to digest fat. as your stomach and intestines digest food, your gallbladder releases bile through a tube called the common bile duct. the duct connects your gallbladder and liver to your small intestine. cancer of the gallbladder is rare. it is more common in women and native americans. symptoms include jaundice (yellowing of the skin and whites of the eyes) pain above the stomach fever nausea and vomiting bloating lumps in the abdomen it is hard to diagnose gallbladder cancer in its early stages. sometimes doctors find it when they remove the gallbladder for another reason. but people with gallstones rarely have gallbladder cancer. because it is often found late, it can be hard to treat gallbladder cancer. treatment options include surgery, chemotherapy, radiation or a combination. nih: national cancer institute²³

MalaCards: Gallbladder Carcinoma, also known as gallbladder cancer, is related to squamous cell carcinoma and prostate carcinoma. An important gene associated with Gallbladder Carcinoma is CR1 (complement component (3b/4b) receptor 1 (Knops blood group)), and among its related pathways are Colorectal cancer and Cell cycle. The drugs carmustine and diethylstilbestrol diphosphate and the compounds dmso and nicotine have been mentioned in the context of this disorder. Affiliated tissues include the tissues of the gallbladder, lymph node and small intestine, and related mouse phenotypes are endocrine/exocrine gland and craniofacial.

Disease Ontology: A carcinoma that is located in the tissues of the gallbladder.⁶

Wikipedia: Gallbladder cancer is a relatively uncommon cancer. It has peculiar geographical distribution being...⁴⁴ more...

Aliases & Descriptions:

gallbladder carcinoma 6 8 32 43 gallbladder cancer 8 32 23 carcinoma of gallbladder (disorder) 6 cancer of the gallbladder 6

carcinoma gallbladder 6 malignant neoplasms 43 carcinoma 43

Diseases related to gallbladder carcinoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1836)

id	Related Disease	Score	Top Affiliating Genes
1	squamous cell carcinoma	41.8	CD44, CDH1, MKI67, CCNA2, CCND1, EGF
2	prostate carcinoma	37.4	VEGFA, CD82, CDH1, MMP9, ERBB2, TP53
3	hepatitis	37.3	FASLG, FAS, GPT, GLUD1, TNFRSF1A, CR1
4	basal cell carcinoma	36.7	BCL2, BAX, CD34, CD44, MMP1, MKI67
5	papillary thyroid carcinoma	36.5	BRAF, VEGFC, RAF1, MUC4, BAX, S100A4
6	neuroendocrine carcinoma	35.8	KIT, MUC1, CEACAM5, CDX2, CDH1, FHIT
7	merkel cell carcinoma	35.1	KIT, KDR, MUC1, FHIT, KRT8, TOP2A
8	adenoid cystic carcinoma	34.9	KIT, PCNA, VIM, MUC1, CEACAM3, CDH1
9	adrenocortical carcinoma	34.2	MKI67, IGF1R, IGF2, TP53, SMAD4
10	renal cell carcinoma	34.1	KIT, PCNA, VIM, BSG, BRAF, VEGFA
11	mucoepidermoid carcinoma	34.1	PCNA, MUC1, MUC2, MUC4, MUC5AC, CEACAM5
12	familial medullary thyroid carcinoma	33.9	BRAF, RAF1, CEACAM5, CEACAM3, TFF1
13	adenosquamous carcinoma	33.4	MUC1, MUC2, MUC4, MUC5AC, CEACAM5, FHIT
14	liver cirrhosis	33.2	RAF1, MUC5AC, CD34, ANGPT2, CCNA2, GPT
15	parathyroid carcinoma	33.1	RB1, CGB5, MKI67, CCND1, TP53, TERT
16	pancreatic ductal carcinoma	32.9	MUC2, MUC5AC, FASLG, SMAD4, KRT8, KRT7
17	multiple endocrine neoplasia	32.6	CDKN1B, CDKN2A, CDH1, FGF2, IGF1R, CTNNB1
18	extrahepatic bile duct carcinoma	32.5	MUC2, CDKN2A, SMAD4
19	anaplastic carcinoma	32.3	VIM, BRAF, MUC1, S100A4, CEACAM3, CDH1
20	collecting duct carcinoma	32.2	VIM, MUC1, CEACAM3, CDKN1B, FHIT, AFP
21	acinar cell carcinoma	32.1	CTNNB1, KRT7, AFP
22	chromophobe renal cell carcinoma	32.1	KIT, PCNA, VIM, MUC1, CCND1, KRT8
23	papillary renal cell carcinoma	32.1	KIT, PCNA, VEGFA, VEGFC, KDR, MUC1
24	large cell carcinoma	32.0	BCL2, BAX, CGB5, CEACAM3, MCL1, IGF2
25	skin carcinoma	32.0	CDH1, MMP2, TP53, PLG, KRT8, THBS1
26	bronchogenic carcinoma	32.0	CGB5, CEACAM5, CDKN2A, TP53, TNF
27	basaloid squamous cell carcinoma	31.8	PCNA, MYC, BIRC5, BAX, CDKN1B, CDKN2A
28	oral cavity cancer	31.7	VEGFA, BAX, ERBB2, TP53, EGFR
29	peritoneal carcinoma	31.7	CEACAM5, MLH1, ERBB2, TP53, EGFR
30	renal oncocytoma	31.6	KIT, PCNA, VIM, MUC1, CD82, CCND1
31	penile cancer	31.5	CDKN2A, HRAS, KRAS
32	lung giant cell carcinoma	31.5	PCNA, CDKN2A, CDH1, MMP2, TIMP2, NME1
33	colorectal cancer	31.5	MSH2, MLH1, CCND1, HRAS, TP53, TNF
34	ovarian cancer	31.5	CEACAM3, ERBB2, KRT7, KRAS, SLC2A1, NME1
35	verrucous carcinoma	31.4	PCNA, RB1, CDKN2A, CD44, CDH1, CCND1
36	stomach carcinoma	31.4	CEACAM5, CDKN2A, CD44, CDH1, MLH1, FAS
37	pituitary carcinoma	31.4	PCNA, MUC1, MGMT, ERBB2, TP53
38	pleomorphic adenoma	31.3	PCNA, VIM, MUC1, CDKN1B, IGF2, HRAS
39	brain cancer	31.3	CD44, MGMT, EGF, EGFR
40	pleomorphic carcinoma	31.3	VIM, MUC1, CGB5, CD99, CDKN1B, TP53
41	thymic carcinoma	31.2	KIT, VIM, VEGFC, BCL2, MUC1, CEACAM5
42	cervix carcinoma	31.2	MYC, CDKN2A, CD44, MKI67, ERBB2, TP53
43	lymphoepithelioma-like carcinoma	31.1	VIM, BCL2, MUC1, CDH1, TP53, EGFR
44	trichoepithelioma	31.0	VIM, BCL2, CD34, CDH1, MKI67, KRT8
45	bile duct carcinoma	30.8	KIT, VEGFC, MYC, BCL2, MUC1, MUC2
46	hypercalcemia	30.7	VIM, FGF2, CCND1, TNF, SRC, EGF
47	colorectal adenoma and carcinoma	30.7	PCNA, VEGFA, BCL2, MUC1, MUC2, BAX
48	small cell carcinoma	30.6	KIT, PCNA, RB1, VIM, VEGFA, BCL2
49	gastritis	30.6	CD34, CDX2, MLH1, MGMT, TERT, NOS2
50	renal clear cell carcinoma	30.6	VIM, VEGFA, BIRC5, KDR, BCL2, MUC1

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 carmustine, diethylstilbestrol, diethylstilbestrol diphosphate, nilutamide

MalaCards organs/tissues related to gallbladder carcinoma:

²²

FMA organs/tissues related to gallbladder carcinoma:

¹¹

MGI Mouse Phenotypes related to gallbladder carcinoma:

²⁵ (show all 26)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.4	CKS2, CDKN1B, CDX2, AFP, ADAM17, KRAS
2	craniofacial phenotype	MP:0005382	9.9	HDAC1, DNMT3B, IGF1R, MIB1, L1CAM, KIT
3	liver/biliary system phenotype	MP:0005370	9.6	DNMT3B, HIF1A, EGFR, PLG, TP53, VEGFA
4	no phenotypic analysis	MP:0003012	8.4	HRAS, CASP6, EZH2, F2R, TP53, PTGS2
5	hematopoietic system phenotype	MP:0005397	8.3	BCL2, CLIC1, BRAF, PCNA, KIT, EPCAM
6	normal phenotype	MP:0002873	8.2	PML, TGFBR2, HIF1A, KRAS, SMAD4, TERT
7	renal/urinary system phenotype	MP:0005367	8.1	SMAD4, PLG, SKP2, KRAS, EGFR, HIF1A
8	adipose tissue phenotype	MP:0005375	7.9	EGFR, NOS2, PTGS2, TNFRSF1A, TNF, TP53
9	embryogenesis phenotype	MP:0005380	7.7	EPCAM, HDAC1, ADAM17, NME1, DNMT3B, EGFR
10	behavior/neurological phenotype	MP:0005386	7.4	HRAS, CASP6, IGF2, IGF1R, TNFRSF1A, SRC
11	limbs/digits/tail phenotype	MP:0005371	7.1	F2R, ERBB2, TNFRSF1A, SRC, CTNNA1, CTNNB1
12	pigmentation phenotype	MP:0001186	7.1	TP53, SRC, CTNNB1, RHO, KRAS, EGFR
13	immune system phenotype	MP:0005387	6.9	EGFR, KRAS, KRT8, PLG, SMAD4, SRC
14	nervous system phenotype	MP:0003631	6.9	CASP7, BAX, RAF1, MYC, BRAF, RB1
15	mortality/aging	MP:0010768	6.9	HDAC9, SMAD4, CTNNA1, TNFRSF1A, TPI1, TP53
16	integument phenotype	MP:0010771	6.2	ERBB2, CD34, CDKN1B, MSH2, L1CAM, MUC1
17	reproductive system phenotype	MP:0005389	6.0	CCND1, L1CAM, CKS2, CKS1B, VEGFA, CD24
18	digestive/alimentary phenotype	MP:0005381	5.9	SMAD4, MMP9, MMP14, CDH1, CD44, CDX2
19	skeleton phenotype	MP:0005390	4.9	THBS1, CASP3, IGF2, IGF1R, CCND1, FAS
20	growth/size phenotype	MP:0005378	4.9	EPCAM, HGF, HDAC9, HDAC1, ADAM17, NME1
21	muscle phenotype	MP:0005369	4.6	EGFR, KRAS, NOS2, SMAD4, CTNNB1, PTGS2
22	tumorigenesis	MP:0002006	3.4	AFP, SMAD4, CTNNB1, CTNNA1, SRC, PTGS2
23	vision/eye phenotype	MP:0005391	2.6	NOS2, CCND1, ANGPT2, FAS, FASLG, FGF2
24	cardiovascular system phenotype	MP:0005385	2.2	HGF, HDAC9, HDAC1, ADAM17, DNMT3B, TGFBR2
25	cellular phenotype	MP:0005384	2.0	CTNNA1, IGF2, IGF1R, CCNB2, CCND1, CCNA2
26	homeostasis/metabolism phenotype	MP:0005376	1.9	MMP2, MUC5AC, MUC1, BCL2, KDR, CLIC1

Articles related to gallbladder carcinoma:

(show top 50)    (show all 119)

id	Title	Authors	Year	Affiliating Genes
1	Correlation between MMP1-PAR1 axis and clinical outco me of primary gallbladder carcinoma. (21835828)	Du X.... Li J.	2011	MMP1, F2R
2	Cyclooxygenase-2, p53 and glucose transporter-1 as pr edictors of malignancy in the development of gallbladder carcinomas. (20846124)	Legan M.	2010	TP53, PTGS2, SLC2A1
3	Expression of LAPTM4B in gallbladder carcinoma cells: the role in invasive potential. (20583413)	Zhou L.... Rui J.A.	2010	LAPTM4B
4	Expressions of VEGF-C and VEGF-D and their correlati on with lymphangiogenesis and angiogenesis in gallbladder carcinoma (20450586)	Jiang L.... Wang X.X.	2010	VEGFC, FIGF
5	Histone deacetylase inhibitor (SAHA) and repression o f EZH2 synergistically inhibit proliferation of gallbladder carcinoma. (19860841)	Yamaguchi J.... Nakanuma Y.	2010	CDH1, HDAC9, EZH2
6	Expression of p16 protein in gallbladder carcinoma an d its precancerous conditions. (20422865)	Choi H.J.... Choi J.H.	2010	CDKN2A
7	Human gallbladder carcinoma: Role of neurotrophins, M IB-1, CD34 and CA15-3. (20353905)	Artico M.... Fumagalli L.	2010	CD34, MUC1, MIB1
8	Reduced expression of Raf-1 kinase inhibitory protein is a significant prognostic marker in patients with gallbladder carcinoma. (20688353)	Kim H.S.... Kim Y.W.	2010	RAF1
9	Prediction of prognosis in gallbladder carcinoma by CD147 and MMP-2 immunohistochemistry. (18665467)	Wu W.... Ruan J.	2009	MMP2, BSG
10	Identification of metastasis-associated proteins invo lved in gallbladder carcinoma metastasis by proteomic analysis and functional e xploration of chloride intracellular channel 1. (19299076)	Wang J.W.... Liu Y.B.	2009	VIM, TPI1, GLUD1
11	Interaction among Rb/p16, Rb/E2F1 and HDAC1 proteins in gallbladder carcinoma. (20037816)	Wang X.... Xu L.	2009	RB1, HDAC1
12	Expression of cyclooxygenase-2, glucose transporter-1 and angiogenesis in gallbladder carcinomas and their impact on prognosis. (19606394)	Legan M.... Marolt V.F.	2009	SLC2A1
13	Heparanase expression in gallbladder carcinoma and its correlation to prognosis. (17524042)	Wu W.... Wang Y.	2008	HPSE
14	Expression of matrix metalloproteinases in gallbladder carcinoma and their significance in carcinogenesis. (18227728)	Karadag N.... Kirimlioglu V.	2008	MMP2, MMP9, MMP14
15	Role of tumor angiogenesis in gallbladder carcinoma: with special reference to thymidine phosphorylase. (18946757)	Harino Y.... Shimada M.	2008	TYMP
16	Inhibitory effect of norcantharidin on the growth of human gallbladder carcinoma GBC-SD cells in vitro. (17287171)	Fan Y.Z.... Chen C.Q.	2007	CCND1, BAX, BIRC5
17	Significance of PML and p53 protein as molecular prognostic markers of gallbladder carcinomas. (18158568)	Chang H.J.... Kim W.H.	2007	CDH1, RB1, TP53
18	Hypoxia inducible factors 1alpha and 2alpha are associated with VEGF expression and angiogenesis in gallbladder carcinomas. (16900513)	Giatromanolaki A.... Koukourakis M.I.	2006	VEGFA, HIF1A, TYMP
19	Somatic mutations of epidermal growth factor receptor in bile duct and gallbladder carcinoma. (16551849)	Leone F.... Aglietta M.	2006	EGFR
20	Immunohistochemically demonstrated lymph node micrometastasis and prognosis in patients with gallbladder carcinoma. (16794394)	Sasaki E.... Nimura Y.	2006	KRT8
21	Arsenic trioxide induces gallbladder carcinoma cell a poptosis via downregulation of Bcl-2. (16904648)	Ai Z.... Qin X.	2006	BCL2
22	Cyclooxygenase-2 promotes angiogenesis by increasing vascular endothelial growth factor and predicts prognosis in gallbladder carcinoma. (15968728)	Zhi Y.H.... Guo R.X.	2005	VEGFA, PTGS2
23	Association of cyclin D1, p16 and retinoblastoma protein expressions with prognosis and metastasis of gallbladder carcinoma. (15655836)	Ma H.B.... Li Y.	2005	RB1, CCND1, CDKN2A
24	Effect of norcantharidin on proliferation and invasion of human gallbladder carcinoma GBC-SD cells. (15832413)	Fan Y.Z.... Chen C.Q.	2005	MMP2, PCNA
25	TP53 abnormalities are frequent and early events in the sequential pathogenesis of gallbladder carcinoma. (16177659)	Moreno M.... Miquel J.F.	2005	TP53
26	The effect of o6-methylguanine-DNA methyltransferase (MGMT) and mismatch repair gene (hMLH1) status on the sensitivity to alkylating agent 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nit rosourea(ACNU) in gallbladder carcinoma cells. (16309194)	Sato K.... Miyazaki K.	2005	MLH1, MGMT
27	Analysis of KIT (CD117) expression in gallbladder carcinomas by tissue microarray. (15336730)	Langner C.... Kornprat P.	2004	KIT
28	Genomic determination of CR1 CD35 density polymorphism on erythrocytes of patients with gallbladder carcinoma. (15526369)	Jiao X.Y.... Shi J.S.	2004	CR1
29	Clinicopathological significance of sialyl Lex expression in human gallbladder carcinoma. (15138547)	Kashiwagi H.... Makuuchi H.	2004	SELE
30	Aberrant promoter hypermethylation of multiple genes in gallbladder carcinoma and chronic cholecystitis. (15447999)	Takahashi T.... Wistuba I.I.	2004	CDH13, TNFRSF10D, PRDM2
31	The in vitro effect of norcantharidin on proliferation and invasion of human gallbladder carcinoma GBC-SD cells and its mechanism (15312360)	Fan Y.Z.... Chen C.Q.	2004	PCNA
32	Mutational analysis of BRAF in gallbladder carcinomas in association with K-ras and p53 mutations and microsatellite instability. (15221372)	Saetta A.A.... Patsouris E.	2004	TP53, BRAF
33	Gallbladder carcinoma: the role of p53 protein overexpression and Ki-67 antigen expression as prognostic markers. (18333072)	Hidalgo Grau L.A.... SuA+ol Sala J.	2004	MKI67
34	Microsatellite instability and p53 expression in gallbladder carcinomas. (12766614)	Sessa F.... Capella C.	2003	TP53, MLH1
35	Significance of expression of epidermal growth factor (EGF) and its receptor (EGFR) in chronic cholecystitis and gallbladder carcinoma (12654182)	Zhou Y.M.... Zeng F.	2003	EGFR, EGF, PCNA
36	A case of gallbladder carcinoma diagnosed preoperatively by the detection of human telomerase reverse transcriptase mRNA in endoscopically obtained gallbladder bile. (12561014)	Uchida N.... Kuriyama S.	2003	TERT
37	Vascular endothelial growth factor (VEGF) expression in operable gallbladder carcinomas. (14624781)	Giatromanolaki A.... Sivridis E.	2003	TYMP
38	Fragile histidine triad gene abnormalities in the pathogenesis of gallbladder carcinoma. (12057912)	Wistuba I.I.... Gazdar A.F.	2002	FHIT
39	CD44 variant overexpression in gallbladder carcinoma associated with tumor dedifferentiation. (11180088)	Yanagisawa N.... Okayasu I.	2001	CD44
40	Gallbladder carcinomas: an immunoprognostic evaluation of P53, Bcl-2, CEA and alpha-fetoprotein. (10758414)	Kanthan R.... Kanthan S.C.	2000	CEACAM3
41	Cyclin D1 overexpression is a critical event in gallbladder carcinogenesis and independently predicts decreased survival for patients with gallbladder carcinoma. (11106243)	Hui A.M.... Makuuchi M.	2000	CCND1
42	Apoptosis in gallbladder carcinomas and dysplasias, its relation to the expression of caspases 3, 6 and 8 and apoptosis regulating proteins bcl-2, mcl-1 and bax. (10668195)	Turunen N.... Soini Y.	2000	BCL2, CASP3, BAX
43	Immunohistochemical detection of lymph node micrometastases from gallbladder carcinoma using monoclonal anticytokeratin antibody. (10193935)	Yokoyama N.... Hatakeyama K.	1999	KRT8
44	Increasing serum levels of alpha-fetoprotein in a patient with relapsing gallbladder carcinoma. (8928700)	Cocquyt V.... Van Belle S.	1996	AFP
45	p53 protein overexpression in gallbladder carcinoma and its precursor lesions: an immunohistochemical study. (8617479)	Wistuba I.I.... Albores-Saavedra J.	1996	TP53
46	The expression and significance of proliferating cell nuclear antigen/cyclin in cholangiocarcinoma and gallbladder carcinoma (8565737)	Yang Z.... Li Y.	1995	PCNA
47	The expressions of proliferating cell nuclear antigen (PCNA) in primary gallbladder carcinoma and its significance (7656696)	Qing D.... Zhang X.	1995	PCNA
48	Gallbladder carcinoma: expression of the c-myc and ras-p-21 oncogene products (7732224)	Roa I.... de Aretxabala X.	1994	MYC
49	Proliferating cell nuclear antigen in gallbladder carcinoma. (8104857)	Roa I.... De-Aretxabala X.	1993	PCNA
50	Gallbladder carcinoma producing human chorionic gonadotropin. (2220737)	Fukuda T.... Ohnishi Y.	1990	CGB5

Genes related to gallbladder carcinoma according to GeneCards:

(show top 50)    (show all 128)

id	Symbol	Description	Score	GeneCards Section Context
1	CR1	complement component (3b/4b) receptor 1 (Knops blood group)	11.1	Summaries, Publications
2	EBAG9	estrogen receptor binding site associated, antigen, 9	11.0	Publications
3	NMT1	N-myristoyltransferase 1	11.0	Publications
4	MUC2	mucin 2, oligomeric mucus/gel-forming	11.0	Publications
5	CDX2	caudal type homeobox 2	11.0	Publications
6	TYMP	thymidine phosphorylase	11.0	Publications
7	NME1	NME/NM23 nucleoside diphosphate kinase 1	11.0	Publications
8	TFF1	trefoil factor 1	11.0	Publications
9	KRT8	keratin 8	11.0	Publications
10	IFI27	interferon, alpha-inducible protein 27	11.0	Publications
11	PCNA	proliferating cell nuclear antigen	11.0	Publications
12	MUC5AC	mucin 5AC, oligomeric mucus/gel-forming	11.0
13	THBS1	thrombospondin 1	11.0	Publications
14	CEACAM5	carcinoembryonic antigen-related cell adhesion molecule 5	11.0	Publications
15	TIMP2	TIMP metallopeptidase inhibitor 2	11.0	Publications
16	CEACAM3	carcinoembryonic antigen-related cell adhesion molecule 3	11.0	Publications
17	CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	11.0	Publications
18	KRT7	keratin 7	11.0
19	CDH1	cadherin 1, type 1, E-cadherin (epithelial)	11.0	Publications
20	RB1	retinoblastoma 1	11.0	Publications
21	SMAD4	SMAD family member 4	11.0	Publications
22	CDK1	cyclin-dependent kinase 1	11.0	Publications
23	CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	11.0	Publications
24	TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	11.0	Publications
25	MKI67	antigen identified by monoclonal antibody Ki-67	11.0	Publications
26	MGMT	O-6-methylguanine-DNA methyltransferase	11.0	Publications
27	BAX	BCL2-associated X protein	11.0	Publications
28	MLH1	mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)	11.0	Publications
29	TERT	telomerase reverse transcriptase	11.0	Publications
30	FHIT	fragile histidine triad	11.0	Publications
31	CKS2	CDC28 protein kinase regulatory subunit 2	11.0	Publications
32	ZMYND10	zinc finger, MYND-type containing 10	11.0	Publications
33	CD24	CD24 molecule	11.0	Publications
34	CLIC1	chloride intracellular channel 1	11.0	Publications
35	CKS1B	CDC28 protein kinase regulatory subunit 1B	11.0	Publications
36	PSME3	proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)	11.0	Publications
37	UBE2C	ubiquitin-conjugating enzyme E2C	11.0	Publications
38	BOK	BCL2-related ovarian killer	11.0	Publications
39	CD99	CD99 molecule	11.0	Publications
40	GBAS	glioblastoma amplified sequence	11.0
41	FIGF	c-fos induced growth factor (vascular endothelial growth factor D)	11.0	Publications
42	EPCAM	epithelial cell adhesion molecule	11.0	Publications
43	CD83	CD83 molecule	11.0	Publications
44	CCNB2	cyclin B2	11.0	Publications
45	TPI1	triosephosphate isomerase 1	11.0	Publications
46	ANXA3	annexin A3	11.0	Publications
47	LAPTM4B	lysosomal protein transmembrane 4 beta	11.0	Publications
48	CASP6	caspase 6, apoptosis-related cysteine peptidase	11.0	Publications
49	SKP2	S-phase kinase-associated protein 2, E3 ubiquitin protein ligase	11.0	Publications
50	HPSE	heparanase	11.0	Publications

Pathways related to gallbladder carcinoma according to GeneDecks:

(show top 50)    (show all 243)

id	Pathway	Score	Top Affiliating Genes
1	Colorectal cancer20	10.6	TGFBR2, BRAF, MSH2
2	Cell cycle20	9.7	CCND1, CCNA2, CCNB2, PCNA, SMAD4, CDK1
3	p53 Signaling36	9.7	BAX, PML, HIF1A, BCL2, CASP3, CASP6
4	Chronic myeloid leukemia20	9.6	BRAF, KRAS, SMAD4, TP53, HRAS, CCND1
5	Non-small cell lung cancer20	9.5	KRAS, EGF, RB1, ERBB2, HRAS, FHIT
6	Akt Signaling36	9.3	KIT, TNFRSF1A, HGF, TNFRSF10D, VEGFC, RAF1
7	Cell adhesion_ECM remodeling41	9.2	PLG, CD44, TIMP2, MMP1, EGFR, EZR
8	Cell adhesion ECM remodeling10	9.2	MMP2, PLG, TIMP2, EGFR, CD44, MMP1
9	Glioblastoma Multiforme36	9.1	RB1, BRAF, RAF1, CDKN1B, MGMT, IGF1R
10	Glioma20	9.0	KRAS, CCND1, CDKN2A, RAF1, EGFR, EGF
11	JNK Pathway36	9.0	TNFRSF10D, TNFRSF1A, EGF, KDR, RAF1, KIT
12	Angiogenesis3	8.9	MMP9, TIMP2, VEGFC, MMP2, TYMP, KDR
13	Apoptosis and Autophagy3	8.9	CFLAR, TYMP, FASLG, CASP3, CASP7, FAS
14	Breast Cancer Regulation by Stathmin136	8.8	EGF, IGF1R, RAF1, CCNB2, FGF2, EGFR
15	Endometrial cancer20	8.8	CTNNB1, KRAS, EGF, EGFR, CTNNA1, TP53
16	ERK5 Signaling36	8.7	IGF2, KIT, VEGFC, MYC, KDR, FLT1
17	Apoptosis20	8.6	FAS, CASP3, CASP6, TP53, TNF, BAX
18	Telomerase Components in Cell Signaling36	8.6	HGF, KDR, FLT1, FIGF, FGF2, IGF1R
19	Melanoma20	8.6	CDKN2A, CDH1, FGF2, CCND1, HRAS, KRAS
20	Prostate cancer20	8.6	RB1, BRAF, RAF1, BCL2, CDKN1B, CCND1
21	TGF-Beta Pathway36	8.6	ANGPT2, IGF2, TNFRSF10D, TNFRSF1A, EGF, EGFR
22	Apoptosis and survival Caspase cascade10	8.6	TNF, CASP6, CASP3, CASP7, IGF1R, FAS
23	Apoptosis Signaling Pathways37	8.6	TNFRSF1A, BIRC5, BCL2, BAX, FAS, CASP7
24	PPAR Pathway36	8.4	KIT, RAF1, TIMP2, IGF1R, EGFR, VEGFC
25	Rho Family GTPases36	8.1	VIM, KIT, ERBB2, TIMP2, HGF, VEGFC
26	14-3-3 Induced Intracellular Signaling36	8.1	TNFRSF1A, SRC, VEGFC, RAF1, FLT1, FIGF
27	Bladder cancer20	8.0	CDH1, MMP1, MMP2, MMP9, FIGF, CCND1
28	Focal adhesion20	8.0	RAF1, VEGFC, BRAF, BCL2, HRAS, FLT1
29	eIF2 Pathway36	7.9	HRAS, EGF, EGFR, TIMP2, HGF, IGF2
30	Apoptotic Pathways in Synovial Fibroblasts36	7.9	TIMP2, HGF, EGFR, EGF, KIT, VEGFC
31	MAPK Family Pathway36	7.8	FGF2, BAX, HRAS, IGF2, ANGPT2, FIGF
32	p53 Mediated Apoptosis36	7.8	FGF2, IGF1R, IGF2, CASP3, CASP6, TP53
33	DHA Signaling36	7.8	IGF1R, FGF2, FIGF, FLT1, BAX, BCL2
34	Nanog in Mammalian ESC Pluripotency36	7.8	EGF, CTNNB1, ERBB2, HRAS, EGFR, TIMP2
35	P2Y Receptor Signaling36	7.8	KIT, RAF1, KDR, FLT1, FIGF, FGF2
36	Endothelin-1 Signaling Pathway36	7.7	CASP7, KIT, BRAF, MYC, RAF1, FLT1
37	ERK Signaling36	7.6	IGF2, HRAS, IGF1R, KIT, MYC, BRAF
38	Mitochondrial Apoptosis36	7.6	KDR, BCL2, BAX, CDKN2A, FLT1, FIGF
39	PAK Pathway36	7.4	FGF2, IGF2, IGF1R, FIGF, FLT1, BAX
40	JAK-STAT Pathway36	7.3	ERBB2, TNFRSF10D, TNFRSF1A, EGF, EGFR, TIMP2
41	Antioxidant Action of Vitamin-C36	7.3	EGF, TNF, KDR, KIT, TNFRSF10D, TNFRSF1A
42	Molecular Mechanisms of Cancer36	7.1	RB1, CASP3, CASP6, HRAS, TP53, CTNNA1
43	ILK Signaling36	6.9	TIMP2, HIF1A, EGFR, EGF, KIT, VIM
44	Cellular Apoptosis Pathway36	6.9	KIT, VEGFC, KDR, BCL2, BAX, CFLAR
45	Colorectal Cancer Metastasis36	6.8	MMP14, MMP2, MMP9, MLH1, CCND1, CASP3
46	Estrogen Pathway36	6.7	KIT, EGFR, TIMP2, HDAC1, HDAC9, HGF
47	p38 Signaling36	6.0	KIT, VEGFC, KDR, BCL2, SRC, EGF
48	MAPK Signaling36	6.0	IGF2, IGF1R, VEGFC, FIGF, FLT1, BCL2
49	Pancreatic Adenocarcinoma36	5.9	KDR, BCL2, CDKN1B, CDKN2A, MMP1, MMP2
50	Pathways in cancer20	5.3	CTNNA1, VEGFC, MYC, BIRC5, BCL2, CKS1B

Compounds related to gallbladder carcinoma according to GeneDecks:

(show top 50)    (show all 440)

id	Compound	Score	Top Affiliating Genes
1	dmso32	10.5	VIM, MUC5AC, CGB5, INTS2, F2R, TNFRSF1A
2	nicotine32 34 9 9	13.5	RB1, BIRC5, GPT
3	roscovitine32	10.4	PCNA, VIM, BIRC5, CDK1, MCL1, CCNA2
4	p00332	10.2	KIT, RB1, CEACAM5, CDKN1B, CD44, CDH1
5	glucose32	10.0	KIT, BRAF, VEGFC, CFLAR, MKI67, MGMT
6	sp 60012532 42	11.0	MMP1, CASP3, TP53
7	crcs32	9.5	RB1, BRAF, BIRC5, MUC1, MUC2, CEACAM5
8	ns 39832 42	10.2	PCNA, CDKN1B, MMP1, FGF2, TNF, TNFRSF1A
9	mitomycin c32	9.1	PCNA, RB1, BIRC5, CEACAM5, MGMT, FGF2
10	formaldehyde32 18	9.9	KIT, PCNA, RB1, SELE, VIM, MUC1
11	cholesterol32 9 18 9	11.9	RB1, SELE, BSG, BIRC5, MUC1, MUC2
12	bromodeoxyuridine32	8.9	PCNA, RB1, VIM, MYC, CDKN1B, CD44
13	retinoid32	8.9	VIM, MYC, BCL2, MUC5AC, BAX, CDH1
14	mifepristone32 42 9 9	11.8	BIRC5, MUC1, BAX, CGB5, MMP1, MKI67
15	camptothecin32 42 9 9	11.8	PCNA, RB1, MYC, BIRC5, KDR, BCL2
16	proline32	8.8	VIM, BSG, MUC2, MUC5AC, MSH2, CDK1
17	calcitriol32 42 9 18 9	12.6	RB1, MYC, CDKN1B, CD83, CD44, CDH1
18	nitric oxide32 9 18 9	11.6	KIT, RB1, SELE, VEGFC, BIRC5, KDR
19	agarose32	8.6	KIT, MYC, BCL2, MUC1, MUC2, BAX
20	p00232	8.5	KIT, RB1, BRAF, BIRC5, CFLAR, CEACAM5
21	oxaliplatin32 34 9 9	11.4	VEGFA, BIRC5, CFLAR, CEACAM5, CDK1, MLH1
22	hyaluronic acid32 18	9.4	VIM, MYC, MUC1, CEACAM5, CD44, CDH1
23	adpribose32	8.2	PCNA, RB1, BIRC5, BCL2, BAX, CDK1
24	creatinine32	8.2	PCNA, SELE, VIM, MUC1, CGB5, CEACAM3
25	troglitazone32 42 9 9	11.1	RB1, SELE, BIRC5, BCL2, BAX, CFLAR
26	phosphotyrosine32	8.1	KIT, RAF1, KDR, MUC5AC, CDK1, CDH1
27	thymidylate32	8.1	PCNA, RB1, VIM, VEGFA, BIRC5, BCL2
28	cytochalasin d32 42	9.0	SELE, VIM, RAF1, CGB5, CD44, CDH1
29	aspirin32 34 18	9.9	PCNA, SELE, RAF1, BIRC5, CGB5, CDH1
30	lactacystin32	7.7	SELE, MYC, RAF1, BIRC5, BCL2, CDKN1B
31	mg 13232 42	8.6	PCNA, MYC, BIRC5, KDR, BAX, CFLAR
32	pdtc32	7.6	SELE, RAF1, BIRC5, BCL2, CFLAR, MMP1
33	calcium32 9 18 9	10.6	KIT, RB1, BRAF, VEGFC, BIRC5, MUC1
34	estrogen32	7.6	PCNA, BSG, VEGFC, RAF1, KDR, MUC2
35	geldanamycin32 9 9	9.5	BRAF, VEGFA, RAF1, BIRC5, KDR, CFLAR
36	trastuzumab32 34 9 9	10.3	KIT, VEGFC, RAF1, BIRC5, KDR, MUC1
37	n acetylcysteine32	7.1	PCNA, SELE, RAF1, BIRC5, KDR, MUC5AC
38	bortezomib32 9 9	9.1	VEGFA, MYC, BIRC5, KDR, BCL2, BAX
39	progesterone32 42 9 18 9	11.0	KIT, PCNA, RB1, BSG, BRAF, VEGFC
40	arsenite32 18	8.0	PCNA, VEGFA, MYC, BIRC5, BCL2, BAX
41	lipid32	6.7	RB1, SELE, VIM, BSG, BRAF, VEGFC
42	docetaxel32 34 9 9	9.5	KIT, VEGFA, MYC, RAF1, BIRC5, KDR
43	thymidine32 18	7.2	KIT, PCNA, RB1, VEGFC, BOK, MYC
44	wortmannin32 42	7.1	VIM, BRAF, RAF1, BIRC5, KDR, BCL2
45	imatinib32 34 9 9	9.0	KIT, BRAF, VEGFA, MYC, RAF1, BIRC5
46	butyrate32	5.9	PCNA, RB1, VIM, MYC, RAF1, BIRC5
47	gemcitabine32 34 9 9	8.9	PCNA, VEGFA, MYC, BIRC5, KDR, BCL2
48	tamoxifen32 34 9 9	8.7	PCNA, SELE, VIM, VEGFA, MYC, RAF1
49	retinoic acid32 42 18	6.5	KIT, RB1, BRAF, VEGFC, BOK, MYC
50	genistein32 9 18 9	6.3	PCNA, RB1, SELE, VIM, VEGFA, MYC

Cellular components related to gallbladder carcinoma according to GeneDecks:

(show all 16)

id	Name	GO ID	Score	Top Affiliating Genes
1	platelet alpha granule lumen	GO:031093	9.9	HGF, THBS1, EGF, PLG, FIGF, VEGFC
2	basolateral plasma membrane	GO:016323	9.5	SLC2A1, EGFR, ERBB2, EZR, CD44, CEACAM5
3	cell surface	GO:009986	9.4	EPCAM, ADAM17, TIMP2, CR1, TNFRSF1A, TNF
4	external side of plasma membrane	GO:009897	9.2	TGFBR2, THBS1, TNF, FAS, FASLG, CD44
5	nucleoplasm	GO:005654	9.0	PCNA, HNRNPK, TP53, TERT, SMAD4, RSF1
6	membrane raft	GO:045121	8.9	ADAM17, EGFR, KRAS, TNFRSF1A, TNF, FAS
7	membrane	GO:016020	8.9	CCND1, IGF1R, CTNNB1, EGFR, SLC2A1, GBAS
8	integral to plasma membrane	GO:005887	8.7	FASLG, IGF1R, F2R, TNF, TNFRSF1A, CR1
9	caveola	GO:005901	8.6	SLC2A1, TGFBR2, SRC, PTGS2, F2R, FASLG
10	perinuclear region of cytoplasm	GO:048471	8.6	ERBB2, CTNNB1, NOS2, EGFR, NME1, HRAS
11	extracellular region	GO:005576	7.3	TNFRSF1A, HPSE, F2R, IGF2, TMEFF2, PLG
12	cytosol	GO:005829	7.0	CTNNB1, CTNNA1, SRC, TPI1, TP53, HRAS
13	extracellular space	GO:005615	6.6	PLG, TNFRSF1A, TNF, IGF2, EGF, EGFR
14	plasma membrane	GO:005886	4.7	CTNNB1, CTNNA1, SRC, TNFRSF1A, TNF, ERBB2
15	cytoplasm	GO:005737	4.3	HRAS, HNRNPK, TP53, TERT, PTGS2, GLUD1
16	nucleus	GO:005634	4.3	ERBB2, TP53, TPI1, TNFRSF1A, PTGS2, HNRNPK

Biological processes related to gallbladder carcinoma according to GeneDecks:

(show top 50)    (show all 98)

id	Name	GO ID	Score	Top Affiliating Genes
1	activation of MAPKK activity	GO:000186	10.7	RAF1, F2R
2	G1 phase of mitotic cell cycle	GO:000080	10.5	CKS1B, RB1, SKP2, CCND1, CDKN2A, CDKN1B
3	S phase of mitotic cell cycle	GO:000084	10.5	CCND1, EZH2, SKP2, PSME3, CDKN1B, CKS1B
4	organ regeneration	GO:031100	10.5	AFP, CDK1, MKI67, ANGPT2, ANXA3, CCND1
5	G1/S transition of mitotic cell cycle	GO:000082	10.4	SKP2, CKS1B, PCNA, RB1, CDK1, CDKN1B
6	mitotic cell cycle	GO:000278	10.3	HDAC1, CDKN2A, CDKN1B, PCNA, RB1, BIRC5
7	extracellular matrix disassembly	GO:022617	10.3	MMP14, MMP2, MMP9, PLG, MMP1, TIMP2
8	response to gamma radiation	GO:010332	10.1	CASP6, TP53, PML, BCL2, MYC, BAX
9	phosphatidylinositol-mediated signaling	GO:048015	10.1	CKS2, CDKN1B, IGF1R, ERBB2, TOP2A, PCNA
10	vascular endothelial growth factor receptor signaling pathway	GO:048010	10.0	KDR, FLT1, VEGFA, FIGF, VEGFC
11	cell cycle arrest	GO:007050	10.0	PML, MYC, MSH2, CDKN1B, CDKN2A, HRAS
12	activation of pro-apoptotic gene products	GO:008633	10.0	FAS, NMT1, IFI27, FASLG, BAX, BCL2
13	negative regulation of neuron apoptotic process	GO:043524	9.8	BAX, BRAF, BCL2, F2R, HIF1A, MSH2
14	cell proliferation	GO:008283	9.8	RAF1, BOK, SKP2, PCNA, CKS1B, CKS2
15	positive regulation of gene expression	GO:010628	9.7	DNMT3B, KRAS, CD44, CDK1, CD34, VEGFA
16	platelet degranulation	GO:002576	9.7	HGF, THBS1, EGF, PLG, VEGFC, VEGFA
17	release of cytochrome c from mitochondria	GO:001836	9.7	BCL2, BAX, CASP3, MYC, CASP7, TP53
18	neuron apoptotic process	GO:051402	9.7	CASP3, FAS, BAX, BCL2, RB1, TP53
19	negative regulation of cell growth	GO:030308	9.7	PML, SMAD4, FGF2, TP53, CDKN2A, CDKN1B
20	induction of apoptosis by intracellular signals	GO:008629	9.6	CASP3, BAX, CASP7, HRAS, TP53, NMT1
21	positive regulation of neuron apoptotic process	GO:043525	9.6	BAX, CASP7, CASP3, CASP6, FASLG, TNF
22	response to cytokine stimulus	GO:034097	9.5	PTGS2, CASP6, MCL1, CTNNB1, PML, BCL2
23	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	9.5	CDKN1B, IFI27, BAX, CDKN2A, FASLG, FAS
24	leukocyte migration	GO:050900	9.5	BSG, L1CAM, KRAS, SRC, HRAS, ANGPT2
25	positive regulation of peptidyl-serine phosphorylation	GO:033138	9.4	TNF, CD44, BCL2, RAF1, BRAF, VEGFA
26	virus-host interaction	GO:019048	9.4	RB1, KDR, PML, BAX, HDAC1, KRT7
27	response to lipopolysaccharide	GO:032496	9.4	F2R, FASLG, TNFRSF1A, SELE, PTGS2, ADAM17
28	positive regulation of epithelial cell proliferation	GO:050679	9.3	VEGFC, MYC, HRAS, ERBB2, EGFR, NME1
29	positive regulation of angiogenesis	GO:045766	9.3	THBS1, MMP9, ANGPT2, FGF2, FLT1, ANXA3
30	MAPK cascade	GO:000165	9.2	RAF1, EGFR, KRAS, TNF, HRAS, CDK1
31	induction of apoptosis	GO:006917	9.2	CDKN1B, TNF, PML, CASP6, CASP3, FAS
32	Ras protein signal transduction	GO:007265	9.1	CCNA2, HRAS, TP53, SRC, KRAS, FGF2
33	induction of apoptosis by extracellular signals	GO:008624	9.1	IFI27, TNFRSF1A, TNF, CASP3, CFLAR, FASLG
34	platelet activation	GO:030168	9.1	F2R, RAF1, PLG, EGF, THBS1, HGF
35	positive regulation of protein phosphorylation	GO:001934	9.1	CCND1, IGF2, HRAS, VEGFA, KRAS, ERBB2
36	negative regulation of transcription, DNA-dependent	GO:045892	8.9	CDKN2A, FGF2, EZH2, CDKN1B, BIRC5, RB1
37	epidermal growth factor receptor signaling pathway	GO:007173	8.8	CDK1, HRAS, ERBB2, SRC, KRAS, EGF
38	positive regulation of cell migration	GO:030335	8.8	KDR, CDH13, MMP14, FLT1, IGF1R, F2R
39	fibroblast growth factor receptor signaling pathway	GO:008543	8.8	SRC, HRAS, CDK1, CDKN1B, BRAF, RAF1
40	positive regulation of MAP kinase activity	GO:043406	8.8	KRAS, EGF, EGFR, CD24, ERBB2, TNF
41	anti-apoptosis	GO:006916	8.8	TNF, HDAC1, MUC1, CDK1, CFLAR, FAS
42	nerve growth factor receptor signaling pathway	GO:048011	8.7	SRC, HDAC1, BRAF, RAF1, CDKN1B, CDK1
43	positive regulation of transcription, DNA-dependent	GO:045893	8.5	HDAC1, RB1, MYC, CDKN2A, CDH1, FGF2
44	response to drug	GO:042493	8.5	DNMT3B, TNF, NME1, ADAM17, PTGS2, CTNNB1
45	response to hypoxia	GO:001666	8.3	ANGPT2, BCL2, CD24, MMP9, RAF1, VEGFA
46	negative regulation of cell proliferation	GO:008285	8.2	TNF, CTNNB1, SMAD4, PLG, TIMP2, PML
47	blood coagulation	GO:007596	8.2	NOS2, BSG, L1CAM, KRAS, EGF, THBS1
48	negative regulation of apoptotic process	GO:043066	7.8	CD44, IGF1R, CASP3, TP53, VEGFA, EGFR
49	apoptotic process	GO:006915	7.7	VIM, BIRC5, RAF1, EBAG9, BOK, BCL2
50	positive regulation of cell proliferation	GO:008284	7.6	HRAS, KIT, VEGFA, VEGFC, MYC, KRAS

Molecular functions related to gallbladder carcinoma according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	BH3 domain binding	GO:051434	10.4	BCL2, BAX, MCL1
2	chemoattractant activity	GO:042056	9.8	FGF2, FIGF, VEGFC, VEGFA
3	protein phosphatase binding	GO:019903	9.7	EGFR, CTNNB1, ERBB2, CDH1, CDKN1B
4	receptor signaling protein tyrosine kinase activity	GO:004716	9.6	EGFR, ERBB2, KDR, KIT
5	transmembrane receptor protein tyrosine kinase activity	GO:004714	9.4	EGFR, ERBB2, FLT1, KDR, KIT
6	growth factor activity	GO:008083	9.3	HGF, TFF1, TYMP, EGF, IGF2, FGF2
7	protein kinase binding	GO:019901	9.3	HIF1A, TP53, CCNB2, CCND1, CCNA2, CDKN2A
8	protease binding	GO:002020	9.3	KIT, BCL2, TP53, TNF, TNFRSF1A
9	transcription factor binding	GO:008134	9.3	HDAC9, HDAC1, HIF1A, CTNNB1, TP53, CD34
10	enzyme binding	GO:019899	9.2	HDAC1, TOP2A, HIF1A, EGFR, CTNNB1, PTGS2
11	protein homodimerization activity	GO:042803	8.8	PML, TOP2A, NOS2, SMAD4, PTGS2, TERT
12	protein tyrosine kinase activity	GO:004713	8.4	EGFR, SRC, ERBB2, IGF1R, KDR, KIT
13	protein heterodimerization activity	GO:046982	8.3	ERBB2, TP53, EGFR, HIF1A, TOP2A, PML
14	identical protein binding	GO:042802	7.9	ERBB2, TP53, TNF, SMAD4, SKP2, EGFR
15	protein binding	GO:005515	1.1	CCND1, ERBB2, TP53, TNF, TNFRSF1A, TERT