MCID: GLL020
MIFTS: 64

Gallbladder Disease

Categories: Gastrointestinal diseases, Genetic diseases, Rare diseases, Liver diseases, Nephrological diseases

Aliases & Classifications for Gallbladder Disease

MalaCards integrated aliases for Gallbladder Disease:

Name: Gallbladder Disease 12 36 14
Gallbladder Diseases 40 41
Abnormality of the Gallbladder 28
Abnormal Gallbladder Function 69
Gallbladder Dysfunction 28
Gall Bladder Diseases 69
Gall Bladder 51

Classifications:



External Ids:

Disease Ontology 12 DOID:0060262
ICD10 32 K82.9 K82.8
ICD9CM 34 575.9
MeSH 41 D005705
NCIt 46 C34631
KEGG 36 H01213

Summaries for Gallbladder Disease

MedlinePlus : 40 Your gallbladder is a pear-shaped organ under your liver. It stores bile, a fluid made by your liver to digest fat. As your stomach and intestines digest food, your gallbladder releases bile through a tube called the common bile duct. The duct connects your gallbladder and liver to your small intestine. Your gallbladder is most likely to give you trouble if something blocks the flow of bile through the bile ducts. That is usually a gallstone. Gallstones form when substances in bile harden. Rarely, you can also get cancer in your gallbladder. Many gallbladder problems get better with removal of the gallbladder. Fortunately, you can live without a gallbladder. Bile has other ways of reaching your small intestine.

MalaCards based summary : Gallbladder Disease, also known as gallbladder diseases, is related to common bile duct disease and arteries, anomalies of, and has symptoms including gastrointestinal gas, nausea and vomiting and icterus. An important gene associated with Gallbladder Disease is GBD2 (Gallbladder Disease 2), and among its related pathways/superpathways are ABC transporters and Fat digestion and absorption. The drugs Ketamine and Nefopam have been mentioned in the context of this disorder. Affiliated tissues include the gallbladder, liver and lung, and related phenotypes are Decreased free cholesterol and homeostasis/metabolism

Disease Ontology : 12 A gastrointestinal system disease that is located in the gallbladder.

Wikipedia : 72 Gallbladder diseases are diseases involving the... more...

Related Diseases for Gallbladder Disease

Diseases in the Gallbladder Disease family:

Gallbladder Disease 1 Gallbladder Disease 2
Gallbladder Disease 3 Gallbladder Disease 4

Diseases related to Gallbladder Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 113)
# Related Disease Score Top Affiliating Genes
1 common bile duct disease 31.5 CCK NODAL
2 arteries, anomalies of 29.3 APOA1 APOB APOE CETP INS
3 coronary artery anomaly 29.3 APOA1 APOB APOE CETP INS
4 body mass index quantitative trait locus 11 29.1 APOA1 APOB APOE CCK CCKAR CETP
5 myocardial infarction 29.1 APOA1 APOB APOE CETP INS
6 diabetes mellitus, noninsulin-dependent 29.0 APOA1 APOB APOE CETP GCKR INS
7 cholelithiasis 29.0 ABCB4 ABCG8 APOE CCK CCKAR UGT1A1
8 gallbladder disease 1 12.3
9 gallbladder disease 4 12.2
10 gall bladder carcinoma in situ 12.1
11 gallbladder disease 2 11.9
12 gallbladder disease 3 11.9
13 fascioliasis 11.4
14 biliary dyskinesia 10.8
15 xanthoma disseminatum 10.5 APOB APOE
16 hypercholesterolemia, autosomal dominant, type b 10.4 APOB APOE
17 familial lcat deficiency 10.4 APOA1 APOE
18 defective apolipoprotein b-100 10.4 APOB APOE
19 leukodystrophy, hypomyelinating, 3 10.4 APOA1 APOB APOE
20 hypobetalipoproteinemia, familial, 1 10.4 APOA1 APOB APOE
21 hyperlipoproteinemia, type v 10.4 APOE INS
22 hyperlipoproteinemia, type iv 10.4 APOA1 APOB APOE
23 ischemic heart disease 10.4 APOA1 APOB APOE
24 fetal macrosomia 10.4 APOA1 APOB INS
25 hypolipoproteinemia 10.4 APOA1 APOB APOE
26 hepatic lipase deficiency 10.3 APOA1 APOE
27 aortic atherosclerosis 10.3 ABCG8 APOE CETP
28 hyperlipidemia, familial combined 10.3 APOA1 APOB APOE
29 cerebral atherosclerosis 10.3 APOA1 APOE
30 hypoalphalipoproteinemia, primary 10.3 APOA1 APOB CETP
31 carotid artery disease 10.3 APOA1 APOB APOE
32 sitosterolemia 10.3 ABCG8 APOB SOAT1
33 stereotypic movement disorder 10.2 CCK MECP2
34 inherited metabolic disorder 10.2 APOA1 APOB INS UGT1A1
35 homozygous familial hypercholesterolemia 10.2 ABCG8 APOB APOE SOAT1
36 disease of mental health 10.2 APOE CCK MECP2
37 arcus corneae 10.2 APOA1 APOB APOE CETP
38 hyperlipoproteinemia, type iii 10.2 APOA1 APOB APOE CETP
39 hyperalphalipoproteinemia 1 10.2 APOA1 APOB APOE CETP
40 coronary stenosis 10.2 APOA1 APOB APOE CETP
41 abetalipoproteinemia 10.2 APOA1 APOB APOE CETP
42 lecithin:cholesterol acyltransferase deficiency 10.2 APOA1 APOB APOE CETP
43 tangier disease 10.2 APOA1 APOB APOE CETP
44 arteriosclerosis 10.2 APOA1 APOB APOE INS
45 gait apraxia 10.2 APOE MECP2
46 cerebrovascular disease 10.2 APOA1 APOB APOE INS
47 body mass index quantitative trait locus 9 10.1
48 body mass index quantitative trait locus 8 10.1
49 body mass index quantitative trait locus 7 10.1
50 body mass index quantitative trait locus 12 10.1

Comorbidity relations with Gallbladder Disease via Phenotypic Disease Network (PDN):


Acute Cystitis Acute Pancreatitis
Esophagitis Heart Disease
Hypertension, Essential Intermediate Coronary Syndrome
Ischemic Heart Disease

Graphical network of the top 20 diseases related to Gallbladder Disease:



Diseases related to Gallbladder Disease

Symptoms & Phenotypes for Gallbladder Disease

UMLS symptoms related to Gallbladder Disease:


gastrointestinal gas, nausea and vomiting, icterus, heartburn, dyspepsia, diarrhea, constipation, abdominal pain

GenomeRNAi Phenotypes related to Gallbladder Disease according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 9.17 ABCG8 APOA1 APOB APOE CETP GCKR

MGI Mouse Phenotypes related to Gallbladder Disease:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.03 CFTR GCKR INS MECP2 NODAL SOAT1
2 cardiovascular system MP:0005385 10.02 ABCB4 APOA1 APOB APOE CDO1 INS
3 endocrine/exocrine gland MP:0005379 9.96 ABCB4 APOA1 APOE CCK CCKAR CDO1
4 digestive/alimentary MP:0005381 9.87 CFTR INS NODAL ABCB4 ABCG8 APOE
5 liver/biliary system MP:0005370 9.7 ABCB4 ABCG8 APOA1 APOB APOE CCKAR
6 vision/eye MP:0005391 9.23 APOB APOE CDO1 CFTR INS MECP2

Drugs & Therapeutics for Gallbladder Disease

Drugs for Gallbladder Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 366)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
2 Nefopam Approved, Investigational Phase 4 13669-70-0
3
Remifentanil Approved Phase 4 132875-61-7 60815
4
Amoxicillin Approved, Vet_approved Phase 4,Phase 3 26787-78-0 33613 2171
5
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
6
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
7
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
8
Droperidol Approved, Vet_approved Phase 4 548-73-2 3168
9
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
10
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
11
Flurbiprofen Approved, Investigational Phase 4 5104-49-4 3394
12
Ropivacaine Approved Phase 4 84057-95-4 175805 71273
13
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
14
Ibuprofen Approved Phase 4 15687-27-1 3672
15
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
16
Meperidine Approved Phase 4 57-42-1 4058
17
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
18
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 5311068 56032 68602
19
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
20
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
21
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
22
Granisetron Approved, Investigational Phase 4 109889-09-0 3510
23
Acetaminophen Approved Phase 4 103-90-2 1983
24
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
25
Ephedrine Approved Phase 4 299-42-3 9294
26
Esmolol Approved Phase 4 81147-92-4, 103598-03-4 59768
27
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
28
Morphine Approved, Investigational Phase 4 57-27-2 5288826
29
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
30
Ondansetron Approved Phase 4 99614-02-5 4595
31
Pseudoephedrine Approved Phase 4 90-82-4 7028
32
Metronidazole Approved Phase 4,Phase 1 443-48-1 4173
33
Ursodeoxycholic acid Approved, Investigational Phase 4,Phase 3 128-13-2 31401
34
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
35
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
36
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
37
Tigecycline Approved Phase 4 220620-09-7 5282044
38
Lactulose Approved Phase 4 4618-18-2 11333
39
Rifaximin Approved, Investigational Phase 4 80621-81-4 6436173
40
chenodeoxycholic acid Approved Phase 4,Phase 2 474-25-9 10133
41
Desflurane Approved Phase 4 57041-67-5 42113
42
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
43
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
44
Ampicillin Approved, Vet_approved Phase 4 69-53-4 6249
45
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
46
Tauroursodeoxycholic acid Approved, Investigational Phase 4 14605-22-2 12443252
47
Sulbactam Approved Phase 4 68373-14-8
48 Sultamicillin Approved, Investigational Phase 4 76497-13-7
49 tannic acid Approved, Nutraceutical Phase 4
50
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 54670067 5785

Interventional clinical trials:

(show top 50) (show all 422)

# Name Status NCT ID Phase Drugs
1 Endoscopic Treatment of Difficult Bile Duct Stones: Spyglass + EHL x Balloon Dilation of the Papilla Unknown status NCT02703077 Phase 4
2 Effect of Intraoperative Nefopam on Acute Pain After Remifentanil Based Anesthesia Unknown status NCT02493231 Phase 4 Nefopam;Ketamine;Saline
3 Extended Antibiotic Therapy in Postoperative of Laparoscopic Cholecystectomy in Acute Cholecystitis Unknown status NCT02057679 Phase 4 Amoxicillin clavulanic;Placebo
4 Efficacy and Safety of Floseal for the Haemostasis During Laparoscopic Cholecystectomy in Acute Cholecystitis (GLA) Unknown status NCT01126281 Phase 4
5 Closed-Loop Target Controlled Infusion in Laparoscopic Cholecystectomy Unknown status NCT02114437 Phase 4
6 Laparo-endoscopic Single Site (LESS) Cholecystectomy Versus Standard LAP-CHOLE Unknown status NCT01339325 Phase 4
7 Day-care Versus Overnight-stay Laparoscopic Cholecystectomy Randomized Controlled Trial. Unknown status NCT01052727 Phase 4
8 Optimal Multimodal Analgesia in Laparoscopic Cholecystectomy Unknown status NCT00209885 Phase 4 Gabapentin;S-ketamine;Lidocaine;Droperidol
9 Effects of Calot's Triangle Block for Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy: a Prospective, Randomized, Double-blind, Controlled, Clinical Trial Unknown status NCT02300480 Phase 4
10 Study of the Use of Humidified Warmed Gas and the Effect on Post-Operative Pain in Laparoscopic Cholecystectomies Unknown status NCT00792389 Phase 4
11 Effect IV Ibuprofen and Inflammatory Responses Completed NCT01938040 Phase 4 ibuprofen
12 A Study Comparing the Use of Deep or Standard Neuromuscular Blockade in Combination With Low or Standard Insufflation Pressures in Participants Undergoing Laparoscopic Cholecystectomy (P07982) Completed NCT01728584 Phase 4 Rocuronium;Sugammadex
13 Efficacy and Safety Profiles of Combination Sedation Propofol With Midazolam and Meperidine. Completed NCT01709422 Phase 4 Propofol;Midazolam;Meperidine
14 Cocktail Sedation Containing Propofol Versus Conventional Sedation for Endoscopic Retrograde Cholangiopancreatography (ERCP) Completed NCT01540084 Phase 4 propofol
15 Minilaparoscopic Versus Conventional Laparoscopic Cholecystectomy Completed NCT01397565 Phase 4
16 Anesthesia With Propofol, Dexmedetomidine and Lidocaine Infusions for Laparoscopic Cholecystectomy Completed NCT01833819 Phase 4 Dexmedetomidine and lidocaine;Remifentanil
17 Vitamin C Efficacy in Reducing Post Operative Pain Completed NCT01322061 Phase 4 Ascorbic Acid
18 Balloon Catheter vs. Basket Catheter for Endoscopic Bile Duct Stone Extraction Completed NCT02909595 Phase 4
19 LaGRA Trial in Laparoscopic Cholecystectomy Completed NCT03394807 Phase 4 Levobupivacaine;Placebo
20 Granisetron Effect on Hemodynamic Changes in Laparoscopic Cholecystectomy Completed NCT03180229 Phase 4 Granisetron 1 Mg/mL Intravenous Solution
21 Endovenous Lidocaine and Serum Cytokines Concentration Completed NCT02363699 Phase 4 Lidocaine;Saline solution
22 Intraoperative Lidocaine Infusion vs. Esmolol Infusion for Postoperative Analgesia in Laparoscopic Cholecystectomy Completed NCT02327923 Phase 4 Lidocaine;Esmolol;Paracetamol;Lidocaine;Propofol;Fentanyl;Vecuronium;Atropine;Ephedrine;Morphine;Ketorolac;Ondansetron;Bupivacaine;Tramadol;Neostigmine;Glycopyrrolate
23 Dual-Loop Target Controlled Infusion in Laparoscopic Cholecystectomy (DLTCI) Completed NCT02116985 Phase 4
24 Oxidative Stress in Standard Laparoscopic vs Single Port Cholecystectomy Completed NCT01211743 Phase 4
25 Multi-Port Versus Single-port Cholecystectomy Completed NCT01104727 Phase 4
26 Cholecyst- Versus Cystic Duct Cholangiography During Laparoscopic Cholecystectomy Completed NCT01103570 Phase 4
27 Levobupivacaine During Cholecystectomy Completed NCT00836316 Phase 4 levobupivacaine
28 Robotic Assisted Versus Laparoscopic Cholecystectomy - Outcome and Cost Analyses of a Case-Matched Control Study Completed NCT00562900 Phase 4
29 DGT Versus TPS in Patients With Initial PD Cannulation by Chance; Prospective Multi-center Study Completed NCT01744847 Phase 4
30 UDCA for Symptomatic Gallstone Disease Completed NCT00161083 Phase 4 ursodeoxycholic acid
31 Pain Reduction After Cholecystectomy Completed NCT01199406 Phase 4 Levobupivacaine
32 Effect of Acupuncture on Postoperative Nausea and Vomiting Completed NCT00674713 Phase 4 Ondansetron;Physiological saline solution;Ondansetron;Physiological saline solution
33 Pain Post Abdominal Laparoscopy Prevention With Arcoxia Completed NCT00565682 Phase 4 etoricoxib 120 mg
34 Biliary Metal Stent Study: Metal Stents for Management of Distal Malignant Biliary Obstruction Completed NCT00280709 Phase 4
35 Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection (cIAI) Completed NCT00230971 Phase 4 tigecycline;ceftriaxone plus metronidazole
36 Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection Completed NCT00195351 Phase 4 tigecycline;ceftriaxone sodium + metronidazole
37 The Safety/Efficacy Of Rifaximin With/Without Lactulose In Subjects With A History Of Recurrent Hepatic Encephalopathy Completed NCT01842581 Phase 4 Rifaximin;Rifaximin and Lactulose
38 The Discovery of the Double Sphincter in Gallbladder Recruiting NCT01998451 Phase 4 Tauroursodeoxycholic acid
39 Changes in Bile Acid Homeostasis and Stool Habits After Cholecystectomy Recruiting NCT03168555 Phase 4 chenodeoxycholic acid
40 Deep Versus Moderate Neuromuscular Blockade During Laparoscopic Surgery Recruiting NCT02812186 Phase 4 Rocuronium
41 Contrastive Study for Minimally Invasive Cholecystolithotomy With Gallbladder Reservation and Laparoscopic Cholecystectomy Recruiting NCT01822262 Phase 4
42 Anesthetic Agents and Acute Kidney Injury After Liver Resection Surgery Recruiting NCT02174575 Phase 4 Sevoflurane;Desflurane
43 Antibiotic Prophylaxis in Laparoscopic Cholecystectomy Suspended NCT01888822 Phase 4 Ciprofloxacin;Ampicillin-sulbactam;Placebo
44 Lithotripsy for the Treatment of Gallstones Terminated NCT00042549 Phase 4 ursodiol
45 The Role of Ursodeoxycholic Acid in Treatment of Gallstones in Hemolytic Disorders Terminated NCT02472509 Phase 4 Ursodeoxycholic Acid
46 Outcome of IV Acetaminophen Use in Laparoscopic Cholecystectomies in Patients at Risk of OSA Withdrawn NCT02056678 Phase 4 acetaminophen, IV preparation
47 Cefoperazone/Sulbactam In The Treatment Of Serious Intra-Abdominal And Hepatobiliary Infections. Withdrawn NCT00463762 Phase 4 CP-75385-02 Cefoperazone/sulbactam
48 Single Port Access (SPA) Cholecystectomy Versus Standard Laparoscopic Cholecystectomy Unknown status NCT00904865 Phase 2, Phase 3
49 Drainage is Not Necessary Procedure After Laparoscopic Cholecystectomy Due to Severe Acute Cholecystitis Unknown status NCT01625247 Phase 3
50 Effect of Saline Irrigation to DEcrease Rate Of Residual Common Bile Duct Stones Unknown status NCT01425177 Phase 3

Search NIH Clinical Center for Gallbladder Disease

Cochrane evidence based reviews: gallbladder diseases

Genetic Tests for Gallbladder Disease

Genetic tests related to Gallbladder Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Gallbladder 28
2 Gallbladder Dysfunction 28

Anatomical Context for Gallbladder Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Gallbladder Disease:

18
The Gallbladder

MalaCards organs/tissues related to Gallbladder Disease:

38
Liver, Lung, Small Intestine, Testes, T Cells, Pancreas, Breast

Publications for Gallbladder Disease

Articles related to Gallbladder Disease:

(show top 50) (show all 468)
# Title Authors Year
1
Multimodality Imaging, including Dual-Energy CT, in the Evaluation of Gallbladder Disease. ( 29320323 )
2018
2
When Does Assessment for Bile Duct Stones Need to Be Performed Prior to Cholecystectomy for Calculus Gallbladder Disease? ( 28669660 )
2017
3
Prognostic significance of promoter DNA hypermethylation of the cysteine dioxygenase 1 (CDO1) gene in primary gallbladder cancer and gallbladder disease. ( 29161283 )
2017
4
Predictors of bile tree pathology in patients presenting with gallbladder disease. ( 28520575 )
2017
5
Feline biliary tree and gallbladder disease: Aetiology, diagnosis and treatment ( 28438089 )
2017
6
Predictors of incidental gallbladder cancer in patients undergoing cholecystectomy for benign gallbladder disease: Results from a population-based gallstone surgery registry. ( 28400123 )
2017
7
Surgical approach to gallbladder disease in rural Guatemala. ( 28985869 )
2017
8
Association between dietary intake and postlaparoscopic cholecystectomic symptoms in patients with gallbladder disease. ( 29117670 )
2017
9
Sex and ethnic/racial-specific risk factors for gallbladder disease. ( 29221432 )
2017
10
Robot-assisted single-site compared with laparoscopic single-incision cholecystectomy for benign gallbladder disease: protocol for a randomized controlled trial. ( 28183345 )
2017
11
Physical Activity and the Risk of Gallbladder Disease: A Systematic Review and Meta-Analysis of Cohort Studies. ( 26901710 )
2016
12
A cross-sectional study of cardiorespiratory fitness and gallbladder disease. ( 27955793 )
2016
13
A Prospective Study of the Conservative Management of Asymptomatic Preoperative and Postoperative Gallbladder Disease in Bariatric Surgery. ( 27324135 )
2016
14
Tobacco smoking and the risk of gallbladder disease. ( 26898907 )
2016
15
Management of gallbladder disease after sleeve gastrectomy in a selected Lebanese population. ( 27178610 )
2016
16
A case report of symptomatic gallbladder disease in the setting of peritoneal carcinomatosis originating from invasive lobular carcinoma of the breast. ( 27180323 )
2016
17
Surgical options for gallbladder disease. ( 27062758 )
2016
18
Contrast-enhanced ultrasound in gallbladder disease: a pictorial review. ( 27056746 )
2016
19
Gallbladder disease in children. ( 27521713 )
2016
20
Diabetes mellitus and the risk of gallbladder disease: A systematic review and meta-analysis of prospective studies. ( 26684168 )
2016
21
Vegetable protein intake is associated with lower gallbladder disease risk: Findings from the Women's Health Initiative prospective cohort. ( 27009631 )
2016
22
MUC Expression in Gallbladder Epithelial Tissues in Cholesterol-Associated Gallbladder Disease. ( 27563024 )
2016
23
The increasing incidence of gallbladder disease in children: A 20year perspective. ( 26951963 )
2016
24
Functional gallbladder disease: Operative trends and short-term outcomes. ( 27129932 )
2016
25
Is transpapillary gallbladder stenting better than percutaneous cholecystostomy for the treatment of symptomatic gallbladder disease in decompensated cirrhotic patients? ( 25647724 )
2015
26
Body mass index, abdominal fatness and the risk of gallbladder disease. ( 26374741 )
2015
27
Polypoid lesions of the gallbladder: disease spectrum with pathologic correlation. ( 25763724 )
2015
28
Dietary patterns and risk of gallbladder disease: a hospital-based case-control study in adult women. ( 25995720 )
2015
29
Lipids, obesity and gallbladder disease in women: insights from genetic studies using the cardiovascular gene-centric 50K SNP array. ( 25920552 )
2015
30
Novel Use of Long, Large-Caliber, Fenestrated Stents for Endoscopic Transpapillary Gallbladder Stenting for Therapy of Symptomatic Gallbladder Disease. ( 26233546 )
2015
31
Transvaginal cholecystectomy vs conventional laparoscopic cholecystectomy for gallbladder disease: A meta-analysis. ( 25954114 )
2015
32
Implications of radiologic-pathologic correlation for gallbladder disease in children and young adults with sickle cell disease. ( 26109240 )
2015
33
Emergency Management of Gallbladder Disease: Are Acute Surgical Units the New Gold Standard? ( 26296834 )
2015
34
Interventional Approaches to Gallbladder Disease. ( 26200981 )
2015
35
Polypoid Lesions of the Gallbladder: Disease Spectrum with Pathologic Correlationa89Erratum. ( 26172366 )
2015
36
Polypoid lesions of the gallbladder: disease spectrum with pathologic correlation-erratum. ( 25969942 )
2015
37
Pain Provocation and Low Gallbladder Ejection Fraction with CCK Cholescintigraphy Are Not Predictive of Chronic Acalculous Gallbladder Disease Symptom Relief After Cholecystectomy. ( 24852884 )
2014
38
Gallbladder disease and cholecystectomies, active component, U.S. Armed Forces, 2004-2013. ( 24978472 )
2014
39
Prevalence, clinical investigation, and management of gallbladder disease in Rett syndrome. ( 24528171 )
2014
40
Different expression of S100A8 in malignant and benign gallbladder diseases. ( 22806545 )
2013
41
Ursodeoxycholic acid therapy in gallbladder disease, a story not yet completed. ( 23964136 )
2013
42
Surgery for acute gallbladder disease in Sweden 1989-2006--a register study. ( 23356689 )
2013
43
Etiology and incidence of pediatric gallbladder disease. ( 24074432 )
2013
44
Gallbladder disease. ( 23826592 )
2013
45
Surgical management of gallbladder disease in the very elderly: are we operating them at the right time? ( 23169310 )
2013
46
Predictors of incidental gallbladder cancer in patients undergoing cholecystectomy for benign gallbladder disease. ( 22886779 )
2013
47
Gallbladder disease in an elderly patient. ( 23842824 )
2013
48
Single-incision versus conventional laparoscopic cholecystectomy in patients with uncomplicated gallbladder disease: a meta-analysis. ( 23238374 )
2012
49
Epidemiology of gallbladder disease: cholelithiasis and cancer. ( 22570746 )
2012
50
Contrast-enhanced ultrasonography in the diagnosis of gallbladder disease. ( 21940376 )
2012

Variations for Gallbladder Disease

Expression for Gallbladder Disease

Search GEO for disease gene expression data for Gallbladder Disease.

Pathways for Gallbladder Disease

Pathways related to Gallbladder Disease according to KEGG:

36
# Name Kegg Source Accession
1 ABC transporters hsa02010
2 Fat digestion and absorption hsa04975
3 Bile secretion hsa04976

Pathways related to Gallbladder Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.19 APOE GCKR INS UGT1A1
2
Show member pathways
11.97 ABCG8 APOA1 APOB APOE CETP SOAT1
3
Show member pathways
11.96 APOA1 APOB APOE INS
4
Show member pathways
11.56 APOA1 APOB APOE
5 11.28 ABCB4 ABCG8 CFTR
6
Show member pathways
11.17 ABCG8 APOA1 APOB APOE CETP SOAT1
7
Show member pathways
10.98 ABCG8 APOA1 APOB
8 10.71 APOA1 CFTR

GO Terms for Gallbladder Disease

Cellular components related to Gallbladder Disease according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.78 APOA1 APOB APOE INS
2 early endosome GO:0005769 9.76 APOA1 APOB APOE CFTR
3 high-density lipoprotein particle GO:0034364 9.54 APOA1 APOE CETP
4 very-low-density lipoprotein particle GO:0034361 9.5 APOA1 APOB APOE
5 endosome lumen GO:0031904 9.49 APOB INS
6 endocytic vesicle lumen GO:0071682 9.43 APOA1 APOB APOE
7 discoidal high-density lipoprotein particle GO:0034365 9.4 APOA1 APOE
8 low-density lipoprotein particle GO:0034362 9.33 APOA1 APOB APOE
9 chylomicron GO:0042627 9.13 APOA1 APOB APOE
10 intermediate-density lipoprotein particle GO:0034363 8.8 APOA1 APOB APOE
11 extracellular space GO:0005615 10.03 APOA1 APOB APOE CCK CETP INS

Biological processes related to Gallbladder Disease according to GeneCards Suite gene sharing:

(show all 42)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.99 ABCB4 ABCG8 APOA1 UGT1A1
2 cellular protein metabolic process GO:0044267 9.96 APOA1 APOB APOE INS
3 lipid transport GO:0006869 9.88 ABCB4 APOA1 APOB APOE CETP
4 response to organic substance GO:0010033 9.86 ABCB4 APOB UGT1A1
5 response to nutrient GO:0007584 9.84 ABCG8 APOA1 CCKAR UGT1A1
6 retinoid metabolic process GO:0001523 9.8 APOA1 APOB APOE
7 phospholipid transport GO:0015914 9.77 ABCG8 APOA1 CETP
8 cholesterol metabolic process GO:0008203 9.77 APOA1 APOB APOE CETP SOAT1
9 lipid homeostasis GO:0055088 9.74 ABCB4 APOE CETP
10 triglyceride catabolic process GO:0019433 9.73 APOA1 APOB APOE
11 lipoprotein metabolic process GO:0042157 9.72 APOA1 APOB APOE
12 reverse cholesterol transport GO:0043691 9.7 APOA1 APOE CETP
13 high-density lipoprotein particle remodeling GO:0034375 9.69 APOA1 APOE CETP
14 positive regulation of nitric-oxide synthase activity GO:0051000 9.68 APOE INS
15 high-density lipoprotein particle assembly GO:0034380 9.68 APOA1 APOE
16 response to glucagon GO:0033762 9.68 ABCB4 CDO1
17 fatty acid homeostasis GO:0055089 9.67 APOE INS
18 phospholipid efflux GO:0033700 9.67 APOA1 APOE
19 phosphatidylcholine metabolic process GO:0046470 9.67 CETP MECP2
20 low-density lipoprotein particle remodeling GO:0034374 9.67 APOB APOE CETP
21 positive regulation of lipid biosynthetic process GO:0046889 9.66 APOE INS
22 very-low-density lipoprotein particle assembly GO:0034379 9.66 APOB SOAT1
23 phospholipid homeostasis GO:0055091 9.65 APOA1 CETP
24 positive regulation of cholesterol esterification GO:0010873 9.65 APOA1 APOE
25 high-density lipoprotein particle clearance GO:0034384 9.64 APOA1 APOE
26 chylomicron remnant clearance GO:0034382 9.64 APOB APOE
27 neuron projection regeneration GO:0031102 9.63 APOA1 APOE
28 chylomicron assembly GO:0034378 9.63 APOA1 APOB APOE
29 steroid metabolic process GO:0008202 9.63 APOA1 APOB APOE CETP SOAT1 UGT1A1
30 regulation of Cdc42 protein signal transduction GO:0032489 9.62 APOA1 APOE
31 very-low-density lipoprotein particle remodeling GO:0034372 9.62 APOE CETP
32 triglyceride homeostasis GO:0070328 9.62 APOA1 APOE CETP GCKR
33 very-low-density lipoprotein particle clearance GO:0034447 9.61 APOB APOE
34 glucocorticoid metabolic process GO:0008211 9.61 APOA1 MECP2
35 chylomicron remodeling GO:0034371 9.61 APOA1 APOB APOE
36 positive regulation of dendritic spine maintenance GO:1902952 9.59 APOE INS
37 lipoprotein catabolic process GO:0042159 9.58 APOB APOE
38 lipoprotein biosynthetic process GO:0042158 9.58 APOA1 APOB APOE
39 cholesterol transport GO:0030301 9.56 APOA1 APOB CETP CFTR
40 cholesterol homeostasis GO:0042632 9.43 ABCG8 APOA1 APOB APOE CETP SOAT1
41 cholesterol efflux GO:0033344 9.02 ABCG8 APOA1 APOB APOE SOAT1
42 lipid metabolic process GO:0006629 10.05 ABCB4 APOA1 APOB APOE CETP SOAT1

Molecular functions related to Gallbladder Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipid binding GO:0008289 9.76 APOA1 APOB APOE CETP
2 hormone activity GO:0005179 9.65 CCK INS MLN
3 phospholipid binding GO:0005543 9.61 APOA1 APOB APOE
4 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.5 ABCB4 ABCG8 CFTR
5 cholesterol binding GO:0015485 9.46 APOA1 APOE CETP SOAT1
6 phospholipid transporter activity GO:0005548 9.43 ABCB4 APOA1 CETP
7 lipoprotein particle binding GO:0071813 9.4 APOA1 APOE
8 phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 9.37 APOA1 APOE
9 lipid transporter activity GO:0005319 9.26 APOA1 APOB APOE CETP
10 cholesterol transporter activity GO:0017127 9.02 ABCG8 APOA1 APOB APOE CETP

Sources for Gallbladder Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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