MCID: GLL020
MIFTS: 59

Gallbladder Disease malady

Gastrointestinal diseases, Nephrological diseases categories

Summaries for Gallbladder Disease

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33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Your gallbladder is a pear-shaped organ under your liver. it stores bile, a fluid made by your liver to digest fat. as your stomach and intestines digest food, your gallbladder releases bile through a tube called the common bile duct. the duct connects your gallbladder and liver to your small intestine. your gallbladder is most likely to give you trouble if something blocks the flow of bile through the bile ducts. that is usually a gallstone. gallstones form when substances in bile harden. rarely, you can also get cancer in your gallbladder. many gallbladder problems get better with removal of the gallbladder. fortunately, you can live without a gallbladder. bile has other ways of reaching your small intestine.

MalaCards: Gallbladder Disease, also known as gall bladder diseases, is related to cholecystitis and adenocarcinoma. An important gene associated with Gallbladder Disease is ABCG8 (ATP-binding cassette, sub-family G (WHITE), member 8), and among its related pathways are Scavenging by Class B Receptors and LDL-mediated lipid transport. The compounds cycloheximide and estrogen have been mentioned in the context of this disorder. Affiliated tissues include liver, small intestine and heart, and related mouse phenotypes are endocrine/exocrine gland and liver/biliary system.

Wikipedia:63 In vertebrates the gallbladder (cholecyst, gall bladder or biliary vesicle) is a small organ where bile... more...

Aliases & Classifications for Gallbladder Disease

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Nephrological diseases


Aliases & Descriptions:

gallbladder disease 8 10
gall bladder diseases 60
gallbladder diseases 33
gall bladder 44


External Ids:

Disease Ontology8 DOID:0000000
MeSH34 D005705
ICD9CM27 575.9
NCIt39 C34631
ICD1025 K82.8

Related Diseases for Gallbladder Disease

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Gallbladder Disease 1 family:

gallbladder disease Gallbladder Disease 2
Gallbladder Disease 3 Gallbladder Disease 4

Diseases related to Gallbladder Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 281)
idRelated DiseaseScoreTop Affiliating Genes
1cholecystitis30.8CCK
2adenocarcinoma30.7CCK, SOAT1, UGT1A1, GGT1
3obesity30.7CCK, SOAT1, APOA1, APOE, APOB, CRP
4acromegaly30.5CCK
5adenoma30.5GGT1
6pancreatitis30.4CCK, CRP, IL10, ABCB4, GGT1, GOT2
7peritonitis30.4CRP
8choledocholithiasis30.4GGT1, ALPL, ALPP, ALPPL2
9peptic ulcer30.3CCK
10diabetes mellitus30.2CCK, ALPPL2, ALPP, ALPL, CETP, GOT1
11sickle cell disease30.2UGT1A1
12cholangitis30.1ALPPL2, ALPP, ALPL, GOT1, GOT2, GGT1
13hepatitis a30.0GOT2, GOT1
14kawasaki disease30.0CRP
15constipation30.0CCK
16obstructive jaundice30.0GGT1, ALPP
17asthma30.0CETP, IL10
18fascioliasis30.0GGT1, GOT2, ALPP
19pneumonia30.0IL10, CRP
20hepatocellular carcinoma30.0SOAT1, UGT1A1, ABCB4, GGT1, GOT2, GOT1
21fatty liver disease30.0APOA1, APOB, GGT1, CETP, ALPP
22abdominal aortic aneurysm29.8APOE
23aortic aneurysm29.8CRP
24acute pancreatitis29.8IL10, CRP, CCK
25hepatitis29.8UGT1A1, GGT1, ALPP
26hepatitis c29.8GGT1, ABCB4, IL10, SOAT1
27vascular disease29.8APOA1, APOE, APOB, CRP, CETP
28breast cancer29.8SOAT1, UGT1A1, ABCB4, ALPL, ALPP, ALPPL2
29hypertension29.8APOA1, APOE, APOB, CRP, GGT1
30coronary artery disease29.8SOAT1, APOA1, APOE, APOB, UGT1A1, CRP
31myocardial infarction29.8APOA1, APOE, APOB, CRP, GOT2, GOT1
32cholelithiasis29.8CCK, UGT1A1, ABCG8, ABCB4, GGT1, ALPL
33cholestasis29.8ALPL, ALPP, ALPPL2, CETP, GOT1, CCK
34bladder disease11.1
35bladder carcinoma10.9
36bladder adenocarcinoma10.5
37bladder tuberculosis10.4
38gall bladder carcinoma in situ10.4
39intestinal disease10.4
40tuberculosis10.4
41liver disease10.3
42gallbladder disease 110.3
43acalculous cholecystitis10.3
44small cell carcinoma10.3
45diabetic autonomic neuropathy10.3
46autonomic neuropathy10.3
47bile duct carcinoma10.3
48diabetic neuropathy10.3
49neuropathy10.3
50gallbladder cancer10.3

Graphical network of the top 20 diseases related to Gallbladder Disease:



Diseases related to gallbladder disease

Clinical Features for Gallbladder Disease

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Drugs & Therapeutics for Gallbladder Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Gallbladder Disease

Drug clinical trials:

Search ClinicalTrials for Gallbladder Disease

Search NIH Clinical Center for Gallbladder Disease

Search CenterWatch for Gallbladder Disease

Genetic Tests for Gallbladder Disease

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Anatomical Context for Gallbladder Disease

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32MalaCards
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MalaCards organs/tissues related to Gallbladder Disease:

32
Liver, Small intestine, Heart, Breast, Testes, Colon, Spinal cord, Kidney, Smooth muscle

Animal Models for Gallbladder Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Gallbladder Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.3ABCB4, CCK, SOAT1, APOA1, ALPL
2MP:00053708.8SOAT1, ABCB4, APOA1, ABCG8, IL10, APOB
3MP:00053858.5ABCB4, IL10, CRP, APOB, APOE, APOA1
4MP:00053767.4APOB, APOE, APOA1, SOAT1, CCK, CRP

Publications for Gallbladder Disease

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Sources:
50PubMed
See all sources

Articles related to Gallbladder Disease:

(show top 50)    (show all 488)
idTitleAuthorsYear
1
Helicobacter pylori in gallbladder mucosa in patients with gallbladder disease. (22350820)
2012
2
Multiple complicated gallbladder disease. (21451808)
2011
3
Clinical, ultrasonographic, and laboratory findings associated with gallbladder disease and rupture in dogs: 45 cases (1997-2007). (19210257)
2009
4
Expression and regulation of megalin in gallbladder mucosa associated with cholesterol gallstone disease]. (19595142)
2009
5
Independent effects of cardiorespiratory fitness, vigorous physical activity, and body mass index on clinical gallbladder disease risk. (18637096)
2008
6
Slow acetylator genotype of N-acetyl transferase2 (NAT2) is associated with increased susceptibility to gallbladder cancer: the cancer risk not modulated by gallstone disease. (17224641)
2007
7
Bacteriuria in patients with gallbladder and biliary tract diseases. (16295397)
2004
8
Gallbladder motility in obesity, diabetes mellitus and coeliac disease. (12974503)
2003
9
The relationship between gallbladder disease and smoking and drinking habits in middle-aged Japanese. (12108680)
2002
10
Contrast-enhanced power Doppler US: is it useful in the differentiation of gallbladder disease? (12213365)
2002
11
Gallbladder muscle dysfunction in patients with chronic acalculous disease. (11159891)
2001
12
An audit of biliary scintigraphy in a district general hospital (1993-1998) with special reference to the investigation of acalculous gallbladder disease. (11065156)
2000
13
Apolipoprotein E genotype and the risk of gallbladder disease in pregnancy. (10613722)
2000
14
Effectiveness of cholecystokinin-stimulated cholescintigraphy in the diagnosis and treatment of acalculous gallbladder disease. (9290518)
1997
15
Gallbladder sensitivity to CCK in duodenal ulcer disease, highly selective and truncal vagotomy. (8714233)
1996
16
The integrity of the cholecystokinin receptor gene in gallbladder disease and obesity. (7489984)
1995
17
Hyperbilirubinemia without common bile duct abnormalities and hyperamylasemia without pancreatitis in patients with gallbladder disease. (7519418)
1994
18
Is gallbladder ejection fraction a reliable predictor of acalculous gall bladder disease? (8321495)
1993
19
Clinical gallbladder disease in NIDDM subjects. Relationship to duration of diabetes and severity of glycemia. (8404432)
1993
20
A case-control study of smoking and gallbladder disease: importance of examining time relations. (1420518)
1992
21
Importance of family history in adolescent gallbladder disease. (1736634)
1992
22
Gallbladder Disease in the Morbidly Obese Patient. (10715661)
1991
23
Gallbladder sensitivity to cholecystokinin in coeliac disease. Correlation of gallbladder contraction with plasma cholecystokinin-like immunoreactivity during infusion of cerulein. (1763298)
1991
24
Central adiposity and gallbladder disease in Mexican Americans. (2916552)
1989
25
Fatty meal provocation monitored by ultrasonography. A method to diagnose ambiguous gallbladder disease. (2965904)
1988
26
FM sonography in gallbladder disease: efficacy and comparison with conventional sonography. (3152400)
1988
27
Individual admixture estimates: disease associations and individual risk of diabetes and gallbladder disease among Mexican-Americans in Starr County, Texas. (3766713)
1986
28
Treatment and prognosis of symptomatic gallbladder disease in patients with cystic fibrosis. (3003321)
1986
29
Socioeconomic status and the prevalence of clinical gallbladder disease. (3877735)
1985
30
Chronic acalculous gallbladder disease: a clinical enigma. (6702210)
1984
31
Gallbladder disease: risk factor for colorectal carcinoma? (6699393)
1984
32
Gallbladder disease in patients on long-term parenteral nutrition. (6401182)
1983
33
The gallbladder in polycystic liver disease. (7054544)
1982
34
Biliary colic and functional gallbladder disease. (7103715)
1982
35
Gallbladder disease and hyperlipoproteinemia. (7389534)
1980
36
Prevalence of clinical gallbladder disease in Mexican-American, Anglo, and black women. (7367932)
1980
37
Real-time ultrasonography. Diagnostic technique of choice in calculous gallbladder disease. (7366693)
1980
38
Ultrasound in the investigation of gallbladder disease. (633551)
1978
39
Surgery for gallbladder disease in the elderly. (324871)
1977
40
Proceedings: Cholecystokinin cholecystography in acalculous gallbladder disease. (4815925)
1974
41
Surgically confirmed gallbladder disease, venous thromboembolism, and breast tumors in relation to postmenopausal estrogen therapy. A report from the Boston Collaborative Drug Surveillance Program, Boston University Medical Center. (4357161)
1974
42
Epidemiology of gallbladder disease in an Appalachian community. (4690207)
1973
43
Gallbladder disease and cholecystectomy: experience with 1500 patients managed in a community hospital. (5774450)
1969
44
Gallbladder disease in infants and children. (4967064)
1968
45
Symptoms of gallbladder disease with a negative cholecystogram. (14023962)
1963
46
Bacteriological investigation of the biliary system and liver in biliary tract disease correlated to clinical data and microstructure of the gallbladder and liver. (13660715)
1959
47
The roentgen diagnosis of gallbladder and biliary tract disease without cholecystography. (13197625)
1954
48
The surgery of gallbladder disease. (14952737)
1952
49
Surgical aspects of gallbladder disease. (20276305)
1946
50
Gallbladder Disease and the X-Ray. (20322645)
1942

Genetic Variations for Gallbladder Disease

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Expression for genes affiliated with Gallbladder Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Gallbladder Disease

Search GEO for disease gene expression data for Gallbladder Disease.

Pathways for genes affiliated with Gallbladder Disease

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Sources:
53Reactome, 29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 49PharmGKB
See all sources

Pathways related to Gallbladder Disease according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1APOA1, APOB
210.1CETP, APOB
3
Hide members
9.9ABCB4, ABCG8, APOA1
4
Hide members
9.9GOT1, GOT2
59.9GOT1, GOT2
6
Hide members
9.8APOA1, APOE, APOB
7
Hide members
9.8APOB, APOE, APOA1
89.8APOA1, APOE, APOB
99.8APOA1, APOB, CRP
109.5APOA1, APOB, ABCG8, GOT2
11
Hide members
9.5APOA1, APOE, APOB, ABCG8, CETP
129.4ALPPL2, ALPP, ALPL
13
NAD metabolism
Hide members
9.4ALPPL2, ALPP, ALPL
149.3GGT1, CRP, APOB, APOA1
15
Hide members
9.1CETP, ABCG8, APOB, APOE, APOA1, SOAT1
16
Hide members
7.8ABCG8, ABCB4, GGT1, GOT2, GOT1, CETP

Compounds for genes affiliated with Gallbladder Disease

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Sources:
44Novoseek, 24HMDB, 28IUPHAR, 11DrugBank, 49PharmGKB, 59Tocris Bioscience
See all sources

Compounds related to Gallbladder Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 133)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.2ALPP
2estrogen4410.1CETP, ABCB4
3campesterol44 2411.0APOA1, APOE, APOB
4lathosterol44 2411.0APOE, ABCG8, CETP, APOB
5cholestyramine4410.0CETP, APOE, APOB, CCK
6taurocholate4410.0APOA1, ABCB4, CCK, APOB
7gemfibrozil44 28 1111.9APOA1, CETP, APOB, APOE
8sitosterol449.9SOAT1, APOE, APOB, ABCG8
9intralipid449.9APOE, CETP, CCK, APOB, APOA1
10chenodeoxycholic acid44 28 11 2412.9APOB, CCK, CETP, ABCB4
11beta-cryptoxanthin449.8GGT1, CRP, APOE
12phosphoethanolamine449.7ALPP, CRP, ALPL
13fenofibrate44 49 1111.7APOA1, CETP, CRP, APOB
14pravastatin44 49 28 11 2413.7CETP, CRP, APOB, APOE, APOA1
157,8-dihydroneopterin44 2410.7ALPL, ALPPL2, ALPP
16probucol44 1110.7CETP, APOB, APOA1, SOAT1, APOE
17homocysteine44 2410.7CETP, APOE, CRP, APOA1, APOB
18dihydroneopterin triphosphate44 2410.7ALPL, ALPPL2, ALPP
19cholesterol ester449.6CETP, APOA1, APOB, APOE, SOAT1
20dihydroxyacetone44 2410.6ALPL, ALPP, ALPPL2
21rosuvastatin44 49 28 1112.6SOAT1, CRP, CETP, APOB, APOA1
22triacylglycerol449.6APOA1, APOE, CETP, APOB, SOAT1
23fluvastatin44 49 28 1112.6CETP, APOE, CRP, UGT1A1, APOB, APOA1
24aspirin44 49 28 2412.5APOB, APOE, CCK, CRP, CETP, APOA1
25acetaldehyde44 28 2411.5CETP, APOE, IL10, APOA1, GGT1
26sterol449.4SOAT1, APOA1, ABCG8, APOB, APOE, CETP
27lovastatin44 49 59 28 1113.4CETP, GGT1, UGT1A1, APOB, APOE, APOA1
28ezetimibe44 1110.3UGT1A1, CETP, ABCG8, SOAT1, APOB, APOA1
29ursodeoxycholic acid44 11 2411.3APOE, ALPP, CCK, GGT1, ABCB4
30phospholipid449.3ABCB4, APOE, SOAT1, APOA1, APOB, ABCG8
31betacarotene449.3IL10, CETP, APOB, CRP, GGT1, APOE
32metformin44 49 1111.2GGT1, APOA1, APOB, CRP
33vitamin a44 11 2411.2APOE, CETP, APOB, APOA1, GGT1, CRP
34guanine44 11 2411.1APOE, UGT1A1, IL10, GGT1, APOA1
35folate449.1ALPP, CRP, APOB, APOE, CCK
36vitamin b12449.0APOB, GGT1, APOA1, APOE, CRP, ALPP
37dexamethasone44 49 28 1112.0UGT1A1, GGT1, CCK, SOAT1, ALPP, ABCB4
38phosphatidylcholine449.0APOB, ABCB4, APOA1, ALPP, SOAT1, CETP
39ascorbic acid44 249.9ALPP, CETP, GGT1, APOA1, APOE, CRP
40simvastatin44 49 59 28 11 2413.8IL10, APOE, CETP, ALPP, CRP, UGT1A1
41tamoxifen44 49 28 1111.8APOE, APOB, UGT1A1, ALPP, APOA1, GGT1
42thyroxine44 249.6CETP, GGT1, IL10, UGT1A1, APOB, APOE
43cyclosporin a44 28 5910.6CCK, ALPP, CETP, ABCB4, IL10, APOE
44atorvastatin44 49 28 11 2412.5CETP, UGT1A1, APOA1, IL10, CRP, APOB
45lipid448.4CRP, ABCG8, SOAT1, ABCB4, CETP, APOB
46bezafibrate44 28 1110.3ALPP, SOAT1, CETP, GGT1, ABCB4, CRP
47aspartate448.2APOA1, APOE, UGT1A1, ALPP, ALPL, CETP
48testosterone44 59 11 2411.1ALPP, CETP, APOB, CRP, UGT1A1, APOE
49alanine448.1ALPP, UGT1A1, SOAT1, APOA1, APOE, APOB
50cholesterol44 28 11 2410.7CCK, SOAT1, APOA1, UGT1A1, APOE, APOB

GO Terms for genes affiliated with Gallbladder Disease

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Sources:
16Gene Ontology
See all sources

Cellular components related to Gallbladder Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate-density lipoprotein particleGO:03436310.0APOE, APOB
2low-density lipoprotein particleGO:03436210.0APOB, APOE
3endocytic vesicle lumenGO:07168210.0APOA1, APOE, APOB
4very-low-density lipoprotein particleGO:0343619.9APOB, APOE, APOA1
5high-density lipoprotein particleGO:0343649.9CETP, APOE, APOA1
6chylomicronGO:0426279.7APOB, APOE
7extracellular spaceGO:0056158.9ALPL, CETP, IL10, CRP, APOB, APOE
8plasma membraneGO:0058867.2APOA1, APOE, APOB, CRP, ABCG8, ABCB4

Biological processes related to Gallbladder Disease according to GeneCards/GeneDecks:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1regulation of Cdc42 protein signal transductionGO:03248910.4APOA1, APOE
2lipoprotein catabolic processGO:04215910.4APOE, APOB
3high-density lipoprotein particle assemblyGO:03438010.4APOA1, APOE
4peripheral nervous system axon regenerationGO:01401210.4APOA1, APOE
5negative regulation of cytokine secretion involved in immune responseGO:00274010.3APOA1, IL10
6high-density lipoprotein particle clearanceGO:03438410.3APOE, APOA1
7phospholipid transportGO:01591410.3CETP, ABCG8
8retinoid metabolic processGO:00152310.3APOE, APOB
9very-low-density lipoprotein particle remodelingGO:03437210.3APOE, CETP
10positive regulation of cholesterol esterificationGO:01087310.3APOA1, APOE
11cholesterol transportGO:03030110.2APOA1, APOB, CETP
12high-density lipoprotein particle remodelingGO:03437510.2APOA1, APOE, CETP
13phospholipid homeostasisGO:05509110.2APOA1, CETP
14glutamate catabolic process to 2-oxoglutarateGO:01955110.2GOT2, GOT1
15lipoprotein biosynthetic processGO:04215810.2APOA1, APOE, APOB
16glutamate catabolic process to aspartateGO:01955010.2GOT2, GOT1
17reverse cholesterol transportGO:04369110.2CETP, APOE, APOA1
18aspartate biosynthetic processGO:00653210.2GOT2, GOT1
19low-density lipoprotein particle remodelingGO:03437410.2APOE, APOB, CETP
20aspartate catabolic processGO:00653310.2GOT2, GOT1
21aspartate metabolic processGO:00653110.2GOT2, GOT1
22response to nutrientGO:00758410.2APOA1, UGT1A1, ABCG8
23receptor-mediated endocytosisGO:00689810.1CETP, APOB, APOE
24very-low-density lipoprotein particle assemblyGO:03437910.1APOB, SOAT1
25phospholipid effluxGO:03370010.0APOE, APOA1
26response to glucocorticoid stimulusGO:05138410.0ALPL, GOT1, IL10
27lipoprotein metabolic processGO:04215710.0CETP, APOB, APOE, APOA1
28negative regulation of macrophage derived foam cell differentiationGO:01074510.0CETP, CRP
29oxaloacetate metabolic processGO:00610710.0GOT2, GOT1
30response to drugGO:0424939.9APOA1, UGT1A1, IL10, ABCG8, ABCB4
31glutamate metabolic processGO:0065369.8GOT2, GOT1
32cholesterol effluxGO:0333449.7SOAT1, APOA1, APOE, APOB, ABCG8
33cholesterol metabolic processGO:0082039.7SOAT1, APOA1, APOE, APOB, CETP
34response to ethanolGO:0454719.6GOT2, CRP, APOE
35phototransduction, visible lightGO:0076039.5APOB, APOE, APOA1
36cholesterol homeostasisGO:0426329.5CETP, ABCG8, APOB, APOE, APOA1, SOAT1
37small molecule metabolic processGO:0442818.4APOA1, APOE, APOB, UGT1A1, ABCG8, ABCB4

Molecular functions related to Gallbladder Disease according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1low-density lipoprotein particle receptor bindingGO:05075010.0APOB, APOE
2phosphatidylcholine-sterol O-acyltransferase activator activityGO:0602289.9APOA1, APOE
3L-aspartate:2-oxoglutarate aminotransferase activityGO:0040699.9GOT1, GOT2
4L-phenylalanine:2-oxoglutarate aminotransferase activityGO:0801309.9GOT1, GOT2
5phospholipid transporter activityGO:0055489.8CETP, APOA1
6cholesterol transporter activityGO:0171279.6CETP, ABCG8, APOB, APOE, APOA1
7cholesterol bindingGO:0154859.6SOAT1, APOA1, CRP, CETP
8alkaline phosphatase activityGO:0040359.5ALPL, ALPP, ALPPL2

Products for genes affiliated with Gallbladder Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gallbladder Disease

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet