MCID: GLL020
MIFTS: 59

Gallbladder Disease malady

Gastrointestinal diseases, Nephrological diseases categories

Summaries for Gallbladder Disease

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33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Your gallbladder is a pear-shaped organ under your liver. it stores bile, a fluid made by your liver to digest fat. as your stomach and intestines digest food, your gallbladder releases bile through a tube called the common bile duct. the duct connects your gallbladder and liver to your small intestine. your gallbladder is most likely to give you trouble if something blocks the flow of bile through the bile ducts. that is usually a gallstone. gallstones form when substances in bile harden. rarely, you can also get cancer in your gallbladder. many gallbladder problems get better with removal of the gallbladder. fortunately, you can live without a gallbladder. bile has other ways of reaching your small intestine.

MalaCards: Gallbladder Disease, also known as gall bladder diseases, is related to cholecystitis and adenocarcinoma. An important gene associated with Gallbladder Disease is ABCG8 (ATP-binding cassette, sub-family G (WHITE), member 8), and among its related pathways are Scavenging by Class B Receptors and LDL-mediated lipid transport. The compounds cycloheximide and estrogen have been mentioned in the context of this disorder. Affiliated tissues include liver, small intestine and heart, and related mouse phenotypes are endocrine/exocrine gland and liver/biliary system.

Wikipedia:63 In vertebrates the gallbladder (cholecyst, gall bladder or biliary vesicle) is a small organ where bile... more...

Aliases & Classifications for Gallbladder Disease

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Nephrological diseases


Aliases & Descriptions:

gallbladder disease 8 10
gall bladder diseases 60
gallbladder diseases 33
gall bladder 44


External Ids:

Disease Ontology8 DOID:0000000
MeSH34 D005705
ICD9CM27 575.9
NCIt39 C34631
ICD1025 K82.8

Related Diseases for Gallbladder Disease

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Gallbladder Disease 1 family:

gallbladder disease Gallbladder Disease 2
Gallbladder Disease 3 Gallbladder Disease 4

Diseases related to Gallbladder Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 281)
idRelated DiseaseScoreTop Affiliating Genes
1cholecystitis30.8CCK
2adenocarcinoma30.7CCK, SOAT1, UGT1A1, GGT1
3obesity30.7CCK, SOAT1, APOA1, APOE, APOB, CRP
4acromegaly30.5CCK
5adenoma30.5GGT1
6pancreatitis30.4CCK, CRP, IL10, ABCB4, GGT1, GOT2
7peritonitis30.4CRP
8choledocholithiasis30.4GGT1, ALPL, ALPP, ALPPL2
9peptic ulcer30.3CCK
10diabetes mellitus30.2CCK, ALPPL2, ALPP, ALPL, CETP, GOT1
11sickle cell disease30.2UGT1A1
12cholangitis30.1ALPPL2, ALPP, ALPL, GOT1, GOT2, GGT1
13hepatitis a30.0GOT2, GOT1
14kawasaki disease30.0CRP
15constipation30.0CCK
16obstructive jaundice30.0GGT1, ALPP
17asthma30.0CETP, IL10
18fascioliasis30.0GGT1, GOT2, ALPP
19pneumonia30.0IL10, CRP
20hepatocellular carcinoma30.0SOAT1, UGT1A1, ABCB4, GGT1, GOT2, GOT1
21fatty liver disease30.0APOA1, APOB, GGT1, CETP, ALPP
22abdominal aortic aneurysm29.8APOE
23aortic aneurysm29.8CRP
24acute pancreatitis29.8IL10, CRP, CCK
25hepatitis29.8UGT1A1, GGT1, ALPP
26hepatitis c29.8GGT1, ABCB4, IL10, SOAT1
27vascular disease29.8APOA1, APOE, APOB, CRP, CETP
28breast cancer29.8SOAT1, UGT1A1, ABCB4, ALPL, ALPP, ALPPL2
29hypertension29.8APOA1, APOE, APOB, CRP, GGT1
30coronary artery disease29.8SOAT1, APOA1, APOE, APOB, UGT1A1, CRP
31myocardial infarction29.8APOA1, APOE, APOB, CRP, GOT2, GOT1
32cholelithiasis29.8CCK, UGT1A1, ABCG8, ABCB4, GGT1, ALPL
33cholestasis29.8ALPL, ALPP, ALPPL2, CETP, GOT1, CCK
34bladder disease11.1
35bladder carcinoma10.9
36bladder adenocarcinoma10.5
37bladder tuberculosis10.4
38gall bladder carcinoma in situ10.4
39intestinal disease10.4
40tuberculosis10.4
41liver disease10.3
42gallbladder disease 110.3
43acalculous cholecystitis10.3
44small cell carcinoma10.3
45diabetic autonomic neuropathy10.3
46autonomic neuropathy10.3
47bile duct carcinoma10.3
48diabetic neuropathy10.3
49neuropathy10.3
50gallbladder cancer10.3

Graphical network of the top 20 diseases related to Gallbladder Disease:



Diseases related to gallbladder disease

Clinical Features for Gallbladder Disease

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Drugs & Therapeutics for Gallbladder Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Gallbladder Disease

Drug clinical trials:

Search ClinicalTrials for Gallbladder Disease

Search NIH Clinical Center for Gallbladder Disease

Search CenterWatch for Gallbladder Disease

Genetic Tests for Gallbladder Disease

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Anatomical Context for Gallbladder Disease

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32MalaCards
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MalaCards organs/tissues related to Gallbladder Disease:

32
Liver, Small intestine, Heart, Breast, Colon, Testes, Spinal cord, Smooth muscle, Kidney

Animal Models for Gallbladder Disease or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Gallbladder Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.3ALPL, ABCB4, APOA1, SOAT1, CCK
2MP:00053708.8SOAT1, APOA1, APOE, APOB, IL10, ABCG8
3MP:00053858.5APOA1, APOE, APOB, CRP, IL10, ABCB4
4MP:00053767.4CCK, SOAT1, APOA1, APOE, APOB, CRP

Publications for Gallbladder Disease

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Sources:
50PubMed
See all sources

Articles related to Gallbladder Disease:

(show top 50)    (show all 488)
idTitleAuthorsYear
1
Gallbladder volume and ejection fraction in patients with BehAset's disease. (21963045)
2012
2
Oral contraceptives and risk of gallbladder disease. (21930751)
2011
3
Expression profile of cholecystokinin type-A receptor in gallbladder cancer and gallstone disease. (21813391)
2011
4
Rsf-1/HBXAP overexpression is associated with disease-specific survival of patients with gallbladder carcinoma. (21995635)
2011
5
Endoscopically obtained bile aspirate is an accurate adjunct in the diagnosis of symptomatic gallbladder disease. (21605510)
2010
6
Gallbladder dysfunction in cholesterol ester storage disease. (19644392)
2010
7
Prospective randomized trial using cost-utility analysis of early versus delayed laparoscopic cholecystectomy for acute gallbladder disease. (19672930)
2009
8
Cholecystokinin receptor A gene polymorphism in gallstone disease and gallbladder cancer. (17944886)
2008
9
Is IL-10-819C/T gene polymorphism modulating the risk of gallbladder disease in north Indian population? (19065724)
2007
10
Gallbladder disease among obese patients in Taiwan. (17546848)
2007
11
Nonalcoholic Fatty gallbladder disease: the influence of diet in lean and obese mice. (16455450)
2006
12
Spontaneous cholecystocutaneous fistula: a rare complication of gallbladder disease. (17086307)
2006
13
Gallbladder disease in cardiac transplant patients: a survey study. (15837892)
2005
14
Endoscopic stent insertion into the gallbladder for symptomatic gallbladder disease in patients with end-stage liver disease. (15672053)
2005
15
Gallbladder disease in young Congolese with sickle cell anemia: an ultrasound survey. (15088794)
2004
16
Cholesterol crystal morphology in acalculous gallbladder disease. (12642747)
2003
17
Association of diabetes, serum insulin, and C-peptide with gallbladder disease. (10655249)
2000
18
Endoscopic ultrasonography for gallbladder disease. (10206779)
1999
19
Trends in mortality from nonneoplastic gallbladder disease. (7541682)
1995
20
Drug-induced gallbladder disease. Incidence, aetiology and management. (1536697)
1992
21
Significance of wall thickness in symptomatic gallbladder disease. (1417489)
1992
22
Increased prevalence of clinical gallbladder disease in subjects with non-insulin-dependent diabetes mellitus. (2196792)
1990
23
Gallbladder disease, bile composition and bile acid absorption after partial ileal bypass. (2083935)
1990
24
Changing trends in surgery for benign gallbladder disease. (3364412)
1988
25
Intragastric bile acid concentrations are unrelated to symptoms of flatulent dyspepsia in patients with and without gallbladder disease and postcholecystectomy. (3557185)
1987
26
Gastric emptying in patients with flatulent dyspepsia, with and without gallbladder disease. (3563410)
1987
27
The role of 99mTc HIDA cholescintigraphy in the diagnosis of acute gallbladder disease: comparison with oral cholecystography and ultrasonography. (3541202)
1986
28
Chronic acalculous gallbladder disease: multiimaging evaluation with clinical-pathologic correlation. (3529895)
1986
29
Endoscopic duodenal aspiration of bile in diagnosis of gallbladder disease. (4047018)
1985
30
Infusion cholecystography in the early diagnosis of acute gallbladder disease. (6388718)
1984
31
Evidence for sphincter dysfunction in patients with gallstone associated pancreatitis: effect of ceruletide in patients undergoing cholecystectomy for gallbladder disease and gallstone associated pancreatitis. (6498460)
1984
32
Preoperative diagnosis of gallbladder disease. (7160162)
1982
33
99mTc-PIPIDA cholescintigraphy in the diagnosis of gallbladder disease. (7148887)
1982
34
The gallbladder in polycystic liver disease. (7253163)
1981
35
Ultrasonography and oral cholecystography: a comparison of their use in the diagnosis of gallbladder disease. (6774698)
1980
36
The use of ultrasonography in the diagnosis of calculous gallbladder disease. (464391)
1979
37
Clofibrate and gallbladder disease. (895770)
1977
38
Does nonopacification of the gallbladder always mean gallbladder disease. (830588)
1977
39
Development and evaluation of use of cholecystokinin in the diagnosis of acalculous gallbladder disease. (802894)
1975
40
Gallbladder disease in hyperlipoproteinaemia. (46958)
1975
41
Incidence of gallbladder disease in Canada, England, and France. (4124435)
1973
42
Umbilical hernia and gallbladder disease. (5791036)
1969
43
Biliary tract disease? Congenital absence of the gallbladder and cystic duct. (5901132)
1966
44
Progress in gallbladder and biliary tract disease. (13626913)
1959
45
Surgical therapy of gallbladder disease. (13525818)
1958
46
Gallbladder disease in young women. (13322276)
1956
47
Medical aspects of noncalculous gallbladder disease. (13268394)
1955
48
Roentgen visualization of the Rokitansky-Aschoff sinuses as an additional sign of chronic gallbladder disease. (13056187)
1953
49
On the correlation between gallbladder disease, obesity, and pregnancy. (15398132)
1949
50
The surgical treatment of gallbladder disease. (21001564)
1946

Genetic Variations for Gallbladder Disease

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Expression for genes affiliated with Gallbladder Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gallbladder Disease

Search GEO for disease gene expression data for Gallbladder Disease.

Pathways for genes affiliated with Gallbladder Disease

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Sources:
53Reactome, 29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 49PharmGKB
See all sources

Pathways related to Gallbladder Disease according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1APOA1, APOB
210.1CETP, APOB
3
Hide members
9.9ABCB4, ABCG8, APOA1
4
Hide members
9.9GOT1, GOT2
59.9GOT1, GOT2
6
Hide members
9.8APOA1, APOE, APOB
7
Hide members
9.8APOB, APOE, APOA1
89.8APOA1, APOE, APOB
99.8APOA1, APOB, CRP
109.5APOA1, APOB, ABCG8, GOT2
11
Hide members
9.5APOA1, APOE, APOB, ABCG8, CETP
129.4ALPPL2, ALPP, ALPL
13
NAD metabolism
Hide members
9.4ALPPL2, ALPP, ALPL
149.3GGT1, CRP, APOB, APOA1
15
Hide members
9.1CETP, ABCG8, APOB, APOE, APOA1, SOAT1
16
Hide members
7.8ABCG8, ABCB4, GGT1, GOT2, GOT1, CETP

Compounds for genes affiliated with Gallbladder Disease

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Sources:
44Novoseek, 24HMDB, 28IUPHAR, 11DrugBank, 49PharmGKB, 59Tocris Bioscience
See all sources

Compounds related to Gallbladder Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 133)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.2ALPP
2estrogen4410.1CETP, ABCB4
3campesterol44 2411.0APOA1, APOE, APOB
4lathosterol44 2411.0APOE, ABCG8, CETP, APOB
5cholestyramine4410.0CETP, APOE, APOB, CCK
6taurocholate4410.0APOA1, ABCB4, CCK, APOB
7gemfibrozil44 28 1111.9APOA1, CETP, APOB, APOE
8sitosterol449.9SOAT1, APOE, APOB, ABCG8
9intralipid449.9APOE, CETP, CCK, APOB, APOA1
10chenodeoxycholic acid44 28 11 2412.9APOB, CCK, CETP, ABCB4
11beta-cryptoxanthin449.8GGT1, CRP, APOE
12phosphoethanolamine449.7ALPP, CRP, ALPL
13fenofibrate44 49 1111.7APOA1, CETP, CRP, APOB
14pravastatin44 49 28 11 2413.7CETP, CRP, APOB, APOE, APOA1
157,8-dihydroneopterin44 2410.7ALPL, ALPPL2, ALPP
16probucol44 1110.7CETP, APOB, APOA1, SOAT1, APOE
17homocysteine44 2410.7CETP, APOE, CRP, APOA1, APOB
18dihydroneopterin triphosphate44 2410.7ALPL, ALPPL2, ALPP
19cholesterol ester449.6CETP, APOA1, APOB, APOE, SOAT1
20dihydroxyacetone44 2410.6ALPL, ALPP, ALPPL2
21rosuvastatin44 49 28 1112.6SOAT1, CRP, CETP, APOB, APOA1
22triacylglycerol449.6APOA1, APOE, CETP, APOB, SOAT1
23fluvastatin44 49 28 1112.6CETP, APOE, CRP, UGT1A1, APOB, APOA1
24aspirin44 49 28 2412.5APOB, APOE, CCK, CRP, CETP, APOA1
25acetaldehyde44 28 2411.5CETP, APOE, IL10, APOA1, GGT1
26sterol449.4SOAT1, APOA1, ABCG8, APOB, APOE, CETP
27lovastatin44 49 59 28 1113.4CETP, GGT1, UGT1A1, APOB, APOE, APOA1
28ezetimibe44 1110.3UGT1A1, CETP, ABCG8, SOAT1, APOB, APOA1
29ursodeoxycholic acid44 11 2411.3APOE, ALPP, CCK, GGT1, ABCB4
30phospholipid449.3ABCB4, APOE, SOAT1, APOA1, APOB, ABCG8
31betacarotene449.3IL10, CETP, APOB, CRP, GGT1, APOE
32metformin44 49 1111.2GGT1, APOA1, APOB, CRP
33vitamin a44 11 2411.2APOE, CETP, APOB, APOA1, GGT1, CRP
34guanine44 11 2411.1APOE, UGT1A1, IL10, GGT1, APOA1
35folate449.1ALPP, CRP, APOB, APOE, CCK
36vitamin b12449.0APOB, GGT1, APOA1, APOE, CRP, ALPP
37dexamethasone44 49 28 1112.0UGT1A1, GGT1, CCK, SOAT1, ALPP, ABCB4
38phosphatidylcholine449.0APOB, ABCB4, APOA1, ALPP, SOAT1, CETP
39ascorbic acid44 249.9ALPP, CETP, GGT1, APOA1, APOE, CRP
40simvastatin44 49 59 28 11 2413.8IL10, APOE, CETP, ALPP, CRP, UGT1A1
41tamoxifen44 49 28 1111.8APOE, APOB, UGT1A1, ALPP, APOA1, GGT1
42thyroxine44 249.6CETP, GGT1, IL10, UGT1A1, APOB, APOE
43cyclosporin a44 28 5910.6CCK, ALPP, CETP, ABCB4, IL10, APOE
44atorvastatin44 49 28 11 2412.5CETP, UGT1A1, APOA1, IL10, CRP, APOB
45lipid448.4CRP, ABCG8, SOAT1, ABCB4, CETP, APOB
46bezafibrate44 28 1110.3ALPP, SOAT1, CETP, GGT1, ABCB4, CRP
47aspartate448.2APOA1, APOE, UGT1A1, ALPP, ALPL, CETP
48testosterone44 59 11 2411.1ALPP, CETP, APOB, CRP, UGT1A1, APOE
49alanine448.1ALPP, UGT1A1, SOAT1, APOA1, APOE, APOB
50cholesterol44 28 11 2410.7CCK, SOAT1, APOA1, UGT1A1, APOE, APOB

GO Terms for genes affiliated with Gallbladder Disease

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Sources:
16Gene Ontology
See all sources

Cellular components related to Gallbladder Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate-density lipoprotein particleGO:03436310.0APOE, APOB
2low-density lipoprotein particleGO:03436210.0APOB, APOE
3endocytic vesicle lumenGO:07168210.0APOA1, APOE, APOB
4very-low-density lipoprotein particleGO:0343619.9APOB, APOE, APOA1
5high-density lipoprotein particleGO:0343649.9CETP, APOE, APOA1
6chylomicronGO:0426279.7APOB, APOE
7extracellular spaceGO:0056158.9ALPL, CETP, IL10, CRP, APOB, APOE
8plasma membraneGO:0058867.2APOA1, APOE, APOB, CRP, ABCG8, ABCB4

Biological processes related to Gallbladder Disease according to GeneCards/GeneDecks:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1regulation of Cdc42 protein signal transductionGO:03248910.4APOA1, APOE
2lipoprotein catabolic processGO:04215910.4APOE, APOB
3high-density lipoprotein particle assemblyGO:03438010.4APOA1, APOE
4peripheral nervous system axon regenerationGO:01401210.4APOA1, APOE
5negative regulation of cytokine secretion involved in immune responseGO:00274010.3APOA1, IL10
6high-density lipoprotein particle clearanceGO:03438410.3APOE, APOA1
7phospholipid transportGO:01591410.3CETP, ABCG8
8retinoid metabolic processGO:00152310.3APOE, APOB
9very-low-density lipoprotein particle remodelingGO:03437210.3APOE, CETP
10positive regulation of cholesterol esterificationGO:01087310.3APOA1, APOE
11cholesterol transportGO:03030110.2APOA1, APOB, CETP
12high-density lipoprotein particle remodelingGO:03437510.2APOA1, APOE, CETP
13phospholipid homeostasisGO:05509110.2APOA1, CETP
14glutamate catabolic process to 2-oxoglutarateGO:01955110.2GOT2, GOT1
15lipoprotein biosynthetic processGO:04215810.2APOA1, APOE, APOB
16glutamate catabolic process to aspartateGO:01955010.2GOT2, GOT1
17reverse cholesterol transportGO:04369110.2CETP, APOE, APOA1
18aspartate biosynthetic processGO:00653210.2GOT2, GOT1
19low-density lipoprotein particle remodelingGO:03437410.2APOE, APOB, CETP
20aspartate catabolic processGO:00653310.2GOT2, GOT1
21aspartate metabolic processGO:00653110.2GOT2, GOT1
22response to nutrientGO:00758410.2APOA1, UGT1A1, ABCG8
23receptor-mediated endocytosisGO:00689810.1CETP, APOB, APOE
24very-low-density lipoprotein particle assemblyGO:03437910.1APOB, SOAT1
25phospholipid effluxGO:03370010.0APOE, APOA1
26response to glucocorticoid stimulusGO:05138410.0ALPL, GOT1, IL10
27lipoprotein metabolic processGO:04215710.0CETP, APOB, APOE, APOA1
28negative regulation of macrophage derived foam cell differentiationGO:01074510.0CETP, CRP
29oxaloacetate metabolic processGO:00610710.0GOT2, GOT1
30response to drugGO:0424939.9APOA1, UGT1A1, IL10, ABCG8, ABCB4
31glutamate metabolic processGO:0065369.8GOT2, GOT1
32cholesterol effluxGO:0333449.7SOAT1, APOA1, APOE, APOB, ABCG8
33cholesterol metabolic processGO:0082039.7SOAT1, APOA1, APOE, APOB, CETP
34response to ethanolGO:0454719.6GOT2, CRP, APOE
35phototransduction, visible lightGO:0076039.5APOB, APOE, APOA1
36cholesterol homeostasisGO:0426329.5CETP, ABCG8, APOB, APOE, APOA1, SOAT1
37small molecule metabolic processGO:0442818.4APOA1, APOE, APOB, UGT1A1, ABCG8, ABCB4

Molecular functions related to Gallbladder Disease according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1low-density lipoprotein particle receptor bindingGO:05075010.0APOB, APOE
2phosphatidylcholine-sterol O-acyltransferase activator activityGO:0602289.9APOA1, APOE
3L-aspartate:2-oxoglutarate aminotransferase activityGO:0040699.9GOT1, GOT2
4L-phenylalanine:2-oxoglutarate aminotransferase activityGO:0801309.9GOT1, GOT2
5phospholipid transporter activityGO:0055489.8CETP, APOA1
6cholesterol transporter activityGO:0171279.6CETP, ABCG8, APOB, APOE, APOA1
7cholesterol bindingGO:0154859.6SOAT1, APOA1, CRP, CETP
8alkaline phosphatase activityGO:0040359.5ALPL, ALPP, ALPPL2

Products for genes affiliated with Gallbladder Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gallbladder Disease

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet