MCID: GLL020
MIFTS: 52

Gallbladder Disease malady

Gastrointestinal category

Summaries for Gallbladder Disease

Sources:
34MedlinePlus, 64Wikipedia, 33MalaCards
See all sources

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MedlinePlus:34 Your gallbladder is a pear-shaped organ under your liver. it stores bile, a fluid made by your liver to digest fat. as your stomach and intestines digest food, your gallbladder releases bile through a tube called the common bile duct. the duct connects your gallbladder and liver to your small intestine. your gallbladder is most likely to give you trouble if something blocks the flow of bile through the bile ducts. that is usually a gallstone. gallstones form when substances in bile harden. rarely, you can also get cancer in your gallbladder. many gallbladder problems get better with removal of the gallbladder. fortunately, you can live without a gallbladder. bile has other ways of reaching your small intestine.

MalaCards: Gallbladder Disease, also known as gall bladder diseases, is related to adenocarcinoma and adenoma. An important gene associated with Gallbladder Disease is ABCG8 (ATP-binding cassette, sub-family G (WHITE), member 8), and among its related pathways are Scavenging by Class B Receptors and LDL-mediated lipid transport. The compounds cycloheximide and estrogen have been mentioned in the context of this disorder. Related mouse phenotypes are endocrine/exocrine gland and liver/biliary system.

Wikipedia:64 In vertebrates the gallbladder (cholecyst, gall bladder or biliary vesicle) is a small organ where bile... more...

Aliases & Classifications for Gallbladder Disease

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal


Aliases & Descriptions:

gallbladder disease 8 10
gall bladder diseases 61
gallbladder diseases 34
gall bladder 45


External Ids:

Disease Ontology8 DOID:0000000
MeSH35 D005705
ICD9CM27 575.9
NCIt40 C34631
ICD1025 K82.8

Related Diseases for Gallbladder Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Gallbladder Disease family:

gallbladder disease 1 gallbladder disease 2
gallbladder disease 3 gallbladder disease 4

Diseases related to Gallbladder Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 270)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.7CCK, SOAT1, UGT1A1, GGT1
2adenoma30.6GGT1
3acromegaly30.5CCK
4choledocholithiasis30.4GGT1, ALPL, ALPP, ALPPL2
5sickle cell disease30.2UGT1A1
6thromboembolism30.2APOA1
7kawasaki disease30.1CRP
8obstructive jaundice30.1GGT1, ALPP
9asthma30.1CETP, IL10
10fascioliasis30.1GGT1, GOT2, ALPP
11fatty liver disease30.1APOA1, APOB, GGT1, CETP, ALPP
12insulin resistance30.1SOAT1, APOA1, APOB, CRP, GGT1, CETP
13abdominal aortic aneurysm29.9APOE
14aortic aneurysm29.9CRP
15pancreatitis, chronic29.9UGT1A1, APOB, CCK
16acute pancreatitis29.9IL10, CRP, CCK
17vascular disease29.8APOA1, APOE, APOB, CRP, CETP
18coronary artery disease,29.8SOAT1, APOA1, APOE, APOB, UGT1A1, CRP
19cholelithiasis29.8CCK, UGT1A1, ABCG8, ABCB4, GGT1, ALPL
20bladder disease11.1
21bladder carcinoma10.9
22gallbladder disease 110.5
23bladder adenocarcinoma10.5
24myxozoa10.5
25gallbladder disease 210.4
26bladder tuberculosis10.4
27n syndrome10.4
28tuberculosis10.4
29acalculous cholecystitis10.3
30small cell carcinoma10.3
31diabetic autonomic neuropathy10.3
32autonomic neuropathy10.3
33bile duct carcinoma10.3
34gastric outlet obstruction10.3
35cystic fibrosis10.3
36nutrition disease10.3
37lip disease10.3
38neuroendocrine carcinoma10.2
39bladder lymphoma10.2
40choledochal cyst10.2
41xanthogranulomatous cholecystitis10.2
42emphysematous cholecystitis10.2
43intestinal atresia10.2
44gall bladder carcinoma in situ10.2
45typhoid fever10.2
46adenosquamous carcinoma10.2
47papillary adenoma10.2
48bladder diverticulum10.2
49autonomic dysfunction10.2
50bacteremia10.2

Graphical network of the top 20 diseases related to Gallbladder Disease:



Diseases related to gallbladder disease

Clinical Features for Gallbladder Disease

Drugs & Therapeutics for Gallbladder Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Gallbladder Disease

Drug clinical trials:

Search ClinicalTrials for Gallbladder Disease

Search NIH Clinical Center for Gallbladder Disease

Search CenterWatch for Gallbladder Disease

Genetic Tests for Gallbladder Disease

Anatomical Context for Gallbladder Disease

Animal Models for Gallbladder Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Gallbladder Disease

Sources:
51PubMed
See all sources

Articles related to Gallbladder Disease:

(show top 50)    (show all 489)
idTitleAuthorsYear
1
Etiology and incidence of pediatric gallbladder disease. (24074432)
2013
2
Incidental gallbladder cancer diagnosed during or after laparoscopic cholecystectomy in members of the Turkish population with gallstone disease. (22234759)
2011
3
APOE and FABP2 Polymorphisms and History of Myocardial Infarction, Stroke, Diabetes, and Gallbladder Disease. (21941641)
2011
4
Clinico-pathological spectrum of gallbladder disease in children. (20491704)
2010
5
Laparoscopic cholecystectomy for gallbladder disease in patients with severe cardiovascular disease. (19440650)
2009
6
Usefulness of lavage cytology during endoscopic transpapillary catheterization into the gallbladder in the cytological diagnosis of gallbladder disease. (19191298)
2009
7
Cholecystectomy for gallbladder disease in elderly aged 80 years and over. (19579587)
2009
8
Gallbladder disease in patients with primary sclerosing cholangitis. (18626441)
2008
9
Fatty liver disease: predictors of nonalcoholic steatohepatitis and gallbladder disease in morbid obesity. (18459024)
2008
10
Gallbladder disease in patients with primary sclerosing cholangitis. (18222013)
2008
11
Gallbladder disease: imaging and treatment. (19005095)
2008
12
SSAT patient care guidelines. Treatment of gallstone and gallbladder disease. (18062077)
2007
13
Comparison of artificial neural networks with logistic regression in prediction of gallbladder disease among obese patients. (17317348)
2007
14
Gallbladder and biliary tract disease in the intensive care unit. (12610852)
2003
15
Histological analysis of gallbladder diseases in relation to opisthorchiasis in endemic areas of Thailand. (14611879)
2003
16
Progress in understanding acalculous gallbladder disease. (11159899)
2001
17
Diagnostic accuracy of 99Tcm-HIDA with cholecystokinin and gallbladder ejection fraction in acalculous gallbladder disease. (11403177)
2001
18
Genetic admixture and gallbladder disease in Mexican Americans. (9696151)
1998
19
Endosonography/bile drainage combination for difficult-to-diagnose gallbladder disease. (9916588)
1998
20
Treatment of gallstone and gallbladder disease using cholecystectomy. The Society for Surgery of the Alimentary Tract Patient Care Committee. (9935327)
1998
21
Prevalence of gallbladder disease and associated clinical variables in a low income population of Mexico City. (8696071)
1996
22
Comparison of preoperative serum CA19-9 levels with results of diagnostic imaging modalities in patients undergoing laparotomy for suspected pancreatic or gallbladder disease. (7846013)
1994
23
Bacteriological studies of bile from the gallbladder in patients with carcinoma of the gallbladder, cholelithiasis, common bile duct stones and no gallstones disease. (7948355)
1994
24
Familial acalculous gallbladder disease. (8434290)
1993
25
Cholecystokinin-enhanced cholescintigraphy in the diagnosis of gallbladder disease. (8360976)
1993
26
Liver and gallbladder disease before and after very-low-calorie diets. (1615889)
1992
27
Factors associated with clinical gallbladder disease in a Canadian Indian population. (2354572)
1990
28
Diabetes, gallbladder disease, obesity, and hypertension among Hispanics in New Mexico. (3195569)
1988
29
Comparison of ultrasonography and oral cholecystography in the diagnosis of gallbladder disease. (6577295)
1983
30
A new look at the multifactoral etiology of gallbladder disease in children. (6859671)
1983
31
A 30-year review of the management of gallbladder disease at a children's hospital. (6614661)
1983
32
Gallbladder disease: current trends and treatments. (6906106)
1980
33
The diagnosis of acute gallbladder disease by technetium-99m-labelled HIDA hepatobiliary scanning. (7427041)
1980
34
Prevalence of gallbladder disease in hyperlipoproteinemia. (222561)
1979
35
Acute gallbladder disease. (718075)
1978
36
Detection of occult gallbladder disease by duodenal drainage. (596531)
1977
37
Gallbladder disease as a side effect of drugs influencing lipid metabolism. Experience in the Coronary Drug Project. (323705)
1977
38
The occurrence and treatment of gallbladder disease in Ontario. (5026536)
1972
39
Peptic ulcers and gallbladder disease. (5420394)
1970
40
Incidence of gallbladder disease after vagotomy. (5798388)
1969
41
Gallbladder disease and sex hormones. A statistical study. (5929095)
1966
42
MORBIDITY AND MORTALITY FROM GALLBLADDER DISEASE. (14048001)
1963
43
Surgery for gallbladder disease in Ohio. A survey of 3,085 operations. (14005516)
1961
44
Functional disturbances of the stomach and duodenum in gallbladder disease. (13544876)
1958
45
Acute gallbladder disease; experience with 103 consecutive cases. (13472465)
1957
46
Gallbladder disease in the aged. (13331768)
1956
47
Gallbladder disease in adolescents and young adults. (13129026)
1954
48
Gallbladder disease-chronic relapsing pancreatitis-diabetes mellitus. (13068496)
1953
49
The Medical Management of Gallbladder Disease. (20892965)
1940
50
FURTHER EVIDENCE THAT PANCREATIC JUICE REFLUX MAY BE ETIOLOGIC FACTOR IN GALLBLADDER DISEASE. (17857315)
1939

Genetic Variations for Gallbladder Disease

Expression for genes affiliated with Gallbladder Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Gallbladder Disease

Search GEO for disease gene expression data for Gallbladder Disease.

Pathways for genes affiliated with Gallbladder Disease

Sources:
54Reactome, 30KEGG, 38NCBI BioSystems Database, 12EMD Millipore, 50PharmGKB
See all sources

Pathways related to Gallbladder Disease according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1APOA1, APOB
210.1CETP, APOB
3
Hide members
9.9ABCB4, ABCG8, APOA1
4
Hide members
9.9GOT1, GOT2
59.9GOT1, GOT2
6
Hide members
9.8APOA1, APOE, APOB
7
Hide members
9.8APOB, APOE, APOA1
89.8APOA1, APOE, APOB
99.8APOA1, APOB, CRP
109.5APOA1, APOB, ABCG8, GOT2
11
Hide members
9.5APOA1, APOE, APOB, ABCG8, CETP
129.4ALPPL2, ALPP, ALPL
13
NAD metabolism
Hide members
9.4ALPPL2, ALPP, ALPL
149.3GGT1, CRP, APOB, APOA1
15
Hide members
9.1CETP, ABCG8, APOB, APOE, APOA1, SOAT1
16
Hide members
7.8ABCG8, ABCB4, GGT1, GOT2, GOT1, CETP

Compounds for genes affiliated with Gallbladder Disease

Sources:
45Novoseek, 24HMDB, 29IUPHAR, 11DrugBank, 50PharmGKB, 60Tocris Bioscience
See all sources

Compounds related to Gallbladder Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 133)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.2ALPP
2estrogen4510.1CETP, ABCB4
3campesterol45 2411.0APOA1, APOE, APOB
4lathosterol45 2411.0APOE, ABCG8, CETP, APOB
5cholestyramine4510.0CETP, APOE, APOB, CCK
6taurocholate4510.0APOA1, ABCB4, CCK, APOB
7gemfibrozil45 29 1111.9APOA1, CETP, APOB, APOE
8sitosterol459.9SOAT1, APOE, APOB, ABCG8
9intralipid459.9APOE, CETP, CCK, APOB, APOA1
10chenodeoxycholic acid45 29 11 2412.9APOB, CCK, CETP, ABCB4
11beta-cryptoxanthin459.8GGT1, CRP, APOE
12phosphoethanolamine459.7ALPP, CRP, ALPL
13fenofibrate45 50 1111.7APOA1, CETP, CRP, APOB
14pravastatin45 50 29 11 2413.7CETP, CRP, APOB, APOE, APOA1
157,8-dihydroneopterin45 2410.7ALPL, ALPPL2, ALPP
16probucol45 1110.7CETP, APOB, APOA1, SOAT1, APOE
17homocysteine45 2410.7CETP, APOE, CRP, APOA1, APOB
18dihydroneopterin triphosphate45 2410.7ALPL, ALPPL2, ALPP
19cholesterol ester459.6CETP, APOA1, APOB, APOE, SOAT1
20dihydroxyacetone45 2410.6ALPL, ALPP, ALPPL2
21rosuvastatin45 50 29 1112.6SOAT1, CRP, CETP, APOB, APOA1
22triacylglycerol459.6APOA1, APOE, CETP, APOB, SOAT1
23fluvastatin45 50 29 1112.6CETP, APOE, CRP, UGT1A1, APOB, APOA1
24aspirin45 50 29 2412.5APOB, APOE, CCK, CRP, CETP, APOA1
25acetaldehyde45 29 2411.5CETP, APOE, IL10, APOA1, GGT1
26sterol459.4SOAT1, APOA1, ABCG8, APOB, APOE, CETP
27lovastatin45 50 60 29 1113.4CETP, GGT1, UGT1A1, APOB, APOE, APOA1
28ezetimibe45 1110.3UGT1A1, CETP, ABCG8, SOAT1, APOB, APOA1
29ursodeoxycholic acid45 11 2411.3APOE, ALPP, CCK, GGT1, ABCB4
30phospholipid459.3ABCB4, APOE, SOAT1, APOA1, APOB, ABCG8
31betacarotene459.3IL10, CETP, APOB, CRP, GGT1, APOE
32metformin45 50 1111.2GGT1, APOA1, APOB, CRP
33vitamin a45 11 2411.2APOE, CETP, APOB, APOA1, GGT1, CRP
34guanine45 11 2411.1APOE, UGT1A1, IL10, GGT1, APOA1
35folate459.1ALPP, CRP, APOB, APOE, CCK
36vitamin b12459.0APOB, GGT1, APOA1, APOE, CRP, ALPP
37dexamethasone45 50 29 1112.0UGT1A1, GGT1, CCK, SOAT1, ALPP, ABCB4
38phosphatidylcholine459.0APOB, ABCB4, APOA1, ALPP, SOAT1, CETP
39ascorbic acid45 249.9ALPP, CETP, GGT1, APOA1, APOE, CRP
40simvastatin45 50 60 29 11 2413.8IL10, APOE, CETP, ALPP, CRP, UGT1A1
41tamoxifen45 50 29 1111.8APOE, APOB, UGT1A1, ALPP, APOA1, GGT1
42thyroxine45 249.6CETP, GGT1, IL10, UGT1A1, APOB, APOE
43cyclosporin a45 29 6010.6CCK, ALPP, CETP, ABCB4, IL10, APOE
44atorvastatin45 50 29 11 2412.5CETP, UGT1A1, APOA1, IL10, CRP, APOB
45lipid458.4CRP, ABCG8, SOAT1, ABCB4, CETP, APOB
46bezafibrate45 29 1110.3ALPP, SOAT1, CETP, GGT1, ABCB4, CRP
47aspartate458.2APOA1, APOE, UGT1A1, ALPP, ALPL, CETP
48testosterone45 60 11 2411.1ALPP, CETP, APOB, CRP, UGT1A1, APOE
49alanine458.1ALPP, UGT1A1, SOAT1, APOA1, APOE, APOB
50cholesterol45 29 11 2410.7CCK, SOAT1, APOA1, UGT1A1, APOE, APOB

GO Terms for genes affiliated with Gallbladder Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Gallbladder Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate-density lipoprotein particleGO:03436310.0APOE, APOB
2low-density lipoprotein particleGO:03436210.0APOB, APOE
3endocytic vesicle lumenGO:07168210.0APOA1, APOE, APOB
4very-low-density lipoprotein particleGO:0343619.9APOB, APOE, APOA1
5high-density lipoprotein particleGO:0343649.9CETP, APOE, APOA1
6chylomicronGO:0426279.7APOB, APOE
7extracellular spaceGO:0056158.9ALPL, CETP, IL10, CRP, APOB, APOE
8plasma membraneGO:0058867.2APOA1, APOE, APOB, CRP, ABCG8, ABCB4

Biological processes related to Gallbladder Disease according to GeneCards/GeneDecks:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1regulation of Cdc42 protein signal transductionGO:03248910.4APOA1, APOE
2lipoprotein catabolic processGO:04215910.4APOE, APOB
3high-density lipoprotein particle assemblyGO:03438010.4APOA1, APOE
4peripheral nervous system axon regenerationGO:01401210.4APOA1, APOE
5negative regulation of cytokine secretion involved in immune responseGO:00274010.3APOA1, IL10
6high-density lipoprotein particle clearanceGO:03438410.3APOE, APOA1
7phospholipid transportGO:01591410.3CETP, ABCG8
8retinoid metabolic processGO:00152310.3APOE, APOB
9very-low-density lipoprotein particle remodelingGO:03437210.3APOE, CETP
10positive regulation of cholesterol esterificationGO:01087310.3APOA1, APOE
11cholesterol transportGO:03030110.2APOA1, APOB, CETP
12high-density lipoprotein particle remodelingGO:03437510.2APOA1, APOE, CETP
13phospholipid homeostasisGO:05509110.2APOA1, CETP
14glutamate catabolic process to 2-oxoglutarateGO:01955110.2GOT2, GOT1
15lipoprotein biosynthetic processGO:04215810.2APOA1, APOE, APOB
16glutamate catabolic process to aspartateGO:01955010.2GOT2, GOT1
17reverse cholesterol transportGO:04369110.2CETP, APOE, APOA1
18aspartate biosynthetic processGO:00653210.2GOT2, GOT1
19low-density lipoprotein particle remodelingGO:03437410.2APOE, APOB, CETP
20aspartate catabolic processGO:00653310.2GOT2, GOT1
21aspartate metabolic processGO:00653110.2GOT2, GOT1
22response to nutrientGO:00758410.2APOA1, UGT1A1, ABCG8
23receptor-mediated endocytosisGO:00689810.1CETP, APOB, APOE
24very-low-density lipoprotein particle assemblyGO:03437910.1APOB, SOAT1
25phospholipid effluxGO:03370010.0APOE, APOA1
26response to glucocorticoid stimulusGO:05138410.0ALPL, GOT1, IL10
27lipoprotein metabolic processGO:04215710.0CETP, APOB, APOE, APOA1
28negative regulation of macrophage derived foam cell differentiationGO:01074510.0CETP, CRP
29oxaloacetate metabolic processGO:00610710.0GOT2, GOT1
30response to drugGO:0424939.9APOA1, UGT1A1, IL10, ABCG8, ABCB4
31glutamate metabolic processGO:0065369.8GOT2, GOT1
32cholesterol effluxGO:0333449.7SOAT1, APOA1, APOE, APOB, ABCG8
33cholesterol metabolic processGO:0082039.7SOAT1, APOA1, APOE, APOB, CETP
34response to ethanolGO:0454719.6GOT2, CRP, APOE
35phototransduction, visible lightGO:0076039.5APOB, APOE, APOA1
36cholesterol homeostasisGO:0426329.5CETP, ABCG8, APOB, APOE, APOA1, SOAT1
37small molecule metabolic processGO:0442818.4APOA1, APOE, APOB, UGT1A1, ABCG8, ABCB4

Molecular functions related to Gallbladder Disease according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1low-density lipoprotein particle receptor bindingGO:05075010.0APOB, APOE
2phosphatidylcholine-sterol O-acyltransferase activator activityGO:0602289.9APOA1, APOE
3L-aspartate:2-oxoglutarate aminotransferase activityGO:0040699.9GOT1, GOT2
4L-phenylalanine:2-oxoglutarate aminotransferase activityGO:0801309.9GOT1, GOT2
5phospholipid transporter activityGO:0055489.8CETP, APOA1
6cholesterol transporter activityGO:0171279.6CETP, ABCG8, APOB, APOE, APOA1
7cholesterol bindingGO:0154859.6SOAT1, APOA1, CRP, CETP
8alkaline phosphatase activityGO:0040359.5ALPL, ALPP, ALPPL2

Products for genes affiliated with Gallbladder Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gallbladder Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet