MCID: GLL015
MIFTS: 27

Gallbladder Squamous Cell Carcinoma

Categories: Cancer diseases, Skin diseases, Gastrointestinal diseases

Aliases & Classifications for Gallbladder Squamous Cell Carcinoma

MalaCards integrated aliases for Gallbladder Squamous Cell Carcinoma:

Name: Gallbladder Squamous Cell Carcinoma 12 14
Squamous Cell Carcinoma of the Gallbladder 12 69
Epidermoid Gallbladder Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5535
NCIt 46 C9170
UMLS 69 C0279658

Summaries for Gallbladder Squamous Cell Carcinoma

MalaCards based summary : Gallbladder Squamous Cell Carcinoma, also known as squamous cell carcinoma of the gallbladder, is related to epididymis cancer and epididymis adenocarcinoma, and has symptoms including abdominal pain An important gene associated with Gallbladder Squamous Cell Carcinoma is CD86 (CD86 Molecule), and among its related pathways/superpathways is Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Capecitabine and Antimetabolites have been mentioned in the context of this disorder. Affiliated tissues include liver and lymph node.

Related Diseases for Gallbladder Squamous Cell Carcinoma

Diseases related to Gallbladder Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 epididymis cancer 10.1 CD86 CEACAM5
2 epididymis adenocarcinoma 10.1 CD86 CEACAM5
3 lymphohistiocytoid mesothelioma 10.1 CD86 CEACAM5
4 liver lymphoma 10.0 CEACAM5 SMUG1
5 splenic tuberculosis 10.0 CEACAM5 SMUG1
6 malignant spiradenoma 10.0 CEACAM5 SMUG1
7 malignant epithelial mesothelioma 10.0 CD86 CEACAM5
8 prostate squamous cell carcinoma 10.0 CEACAM5 SMUG1
9 tolosa-hunt syndrome 10.0 CEACAM5 SMUG1
10 gastric signet ring cell adenocarcinoma 10.0 CEACAM5 SMUG1
11 eccrine adenocarcinoma 10.0 CEACAM5 SMUG1
12 femoral neuropathy 10.0 CEACAM5 SMUG1
13 descending colon cancer 10.0 CEACAM5 SMUG1
14 pericardial tuberculosis 10.0 CEACAM5 SMUG1
15 tuberculous peritonitis 10.0 CEACAM5 SMUG1
16 tracheal cancer 10.0 CEACAM5 SMUG1
17 xanthogranulomatous cholecystitis 9.9 CEACAM5 SMUG1
18 rectal neoplasm 9.9 CEACAM5 SMUG1
19 intracystic papillary adenoma 9.9 CEACAM5 ERBB2
20 endocrine gland cancer 9.8 CEACAM5 SMUG1
21 squamous cell carcinoma 9.8
22 breast metaplastic carcinoma 9.8 CEACAM5 ERBB2
23 papillary adenocarcinoma 9.8 CEACAM5 ERBB2
24 malignant ovarian surface epithelial-stromal neoplasm 9.8 CEACAM5 ERBB2
25 ovary epithelial cancer 9.7 CEACAM5 ERBB2
26 mucoepidermoid carcinoma 9.7 CEACAM5 ERBB2
27 gallbladder cancer 9.6 CEACAM5 ERBB2
28 reproductive organ cancer 9.6 ERBB2 SMUG1
29 cholangiocarcinoma 9.6 CEACAM5 ERBB2
30 gastric adenocarcinoma 9.5 CEACAM5 ERBB2
31 vulval paget's disease 9.5 CD86 CEACAM5 ERBB2
32 vulva adenocarcinoma 9.5 CD86 CEACAM5 ERBB2
33 breast squamous cell carcinoma 9.5 CD86 CEACAM5 ERBB2
34 ovarian cancer 1 9.5 CD86 CEACAM5 ERBB2
35 female reproductive organ cancer 9.4 CEACAM5 ERBB2 SMUG1
36 gastrointestinal system cancer 9.4 CEACAM5 ERBB2 SMUG1
37 cell type cancer 9.4 CEACAM5 ERBB2 SMUG1
38 lung cancer susceptibility 3 9.4 CEACAM5 ERBB2

Graphical network of the top 20 diseases related to Gallbladder Squamous Cell Carcinoma:



Diseases related to Gallbladder Squamous Cell Carcinoma

Symptoms & Phenotypes for Gallbladder Squamous Cell Carcinoma

UMLS symptoms related to Gallbladder Squamous Cell Carcinoma:


abdominal pain

Drugs & Therapeutics for Gallbladder Squamous Cell Carcinoma

Drugs for Gallbladder Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Capecitabine Approved, Investigational Phase 3,Phase 2 154361-50-9 60953
2 Antimetabolites Phase 3,Phase 2
3 Antimetabolites, Antineoplastic Phase 3,Phase 2
4 Liver Extracts Phase 3
5
Gemcitabine Approved Phase 2 95058-81-4 60750
6
Sorafenib Approved, Investigational Phase 2 284461-73-0 216239 406563
7
Niacin Approved, Investigational, Nutraceutical Phase 2 59-67-6 938
8
Nicotinamide Approved, Investigational, Nutraceutical Phase 2 98-92-0 936
9
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
10 Micronutrients Phase 2
11 Trace Elements Phase 2
12 Nicotinic Acids Phase 2
13 Vitamin B Complex Phase 2
14 Vitamins Phase 2
15 Anti-Infective Agents Phase 2
16 Immunosuppressive Agents Phase 2
17 Protein Kinase Inhibitors Phase 2
18 Antiviral Agents Phase 2
19 Folate Nutraceutical Phase 2
20 Vitamin B3 Nutraceutical Phase 2
21 Vitamin B9 Nutraceutical Phase 2
22
Ethanol Approved 64-17-5 702
23
Dimenhydrinate Approved 523-87-5 441281
24
Hydrogen peroxide Approved, Vet_approved 7722-84-1 784
25 Pharmaceutical Solutions
26 Immunoglobulins
27 Antibodies

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Capecitabine or Observation After Surgery in Treating Patients With Biliary Tract Cancer Completed NCT00363584 Phase 3 capecitabine
2 S0514 Sorafenib in Treating Patients With Unresectable or Metastatic Gallbladder Cancer or Cholangiocarcinoma Completed NCT00238212 Phase 2 sorafenib tosylate
3 S0202 Gemcitabine and Capecitabine for Unresectable Locally Advanced Metastatic Gallbladder Cancer or Cholangiocarcinoma Completed NCT00033540 Phase 2 capecitabine;gemcitabine hydrochloride
4 OX-40 Protein Expression in the Sentinel Lymph Nodes of Patients With Cancer Completed NCT00900302

Search NIH Clinical Center for Gallbladder Squamous Cell Carcinoma

Genetic Tests for Gallbladder Squamous Cell Carcinoma

Anatomical Context for Gallbladder Squamous Cell Carcinoma

MalaCards organs/tissues related to Gallbladder Squamous Cell Carcinoma:

38
Liver, Lymph Node

Publications for Gallbladder Squamous Cell Carcinoma

Articles related to Gallbladder Squamous Cell Carcinoma:

# Title Authors Year
1
Gallbladder squamous cell carcinoma in the setting of low-dose methotrexate use. ( 19895533 )
2009

Variations for Gallbladder Squamous Cell Carcinoma

Expression for Gallbladder Squamous Cell Carcinoma

Search GEO for disease gene expression data for Gallbladder Squamous Cell Carcinoma.

Pathways for Gallbladder Squamous Cell Carcinoma

Pathways related to Gallbladder Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.69 CD86 CEACAM5

GO Terms for Gallbladder Squamous Cell Carcinoma

Cellular components related to Gallbladder Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 basolateral plasma membrane GO:0016323 8.62 CEACAM5 ERBB2

Biological processes related to Gallbladder Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein kinase B signaling GO:0051897 8.96 CD86 ERBB2
2 phosphatidylinositol phosphorylation GO:0046854 8.62 CD86 ERBB2

Molecular functions related to Gallbladder Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 8.62 CD86 ERBB2

Sources for Gallbladder Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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