MCID: GLL015
MIFTS: 25

Gallbladder Squamous Cell Carcinoma malady

Categories: Cancer diseases, Gastrointestinal diseases, Skin diseases

Aliases & Classifications for Gallbladder Squamous Cell Carcinoma

Aliases & Descriptions for Gallbladder Squamous Cell Carcinoma:

Name: Gallbladder Squamous Cell Carcinoma 12 14
Squamous Cell Carcinoma of the Gallbladder 12 69
Epidermoid Gallbladder Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5535
NCIt 47 C9170
UMLS 69 C0279658

Summaries for Gallbladder Squamous Cell Carcinoma

MalaCards based summary : Gallbladder Squamous Cell Carcinoma, also known as squamous cell carcinoma of the gallbladder, is related to yaws and suppression amblyopia, and has symptoms including abdominal pain An important gene associated with Gallbladder Squamous Cell Carcinoma is CD86 (CD86 Molecule), and among its related pathways/superpathways is Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Capecitabine and Fentanyl have been mentioned in the context of this disorder.

Related Diseases for Gallbladder Squamous Cell Carcinoma

Diseases related to Gallbladder Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
id Related Disease Score Top Affiliating Genes
1 yaws 10.1 CD86 CEACAM5
2 suppression amblyopia 10.1 CD86 CEACAM5
3 ovarian endometrioid cystadenofibroma 10.1 CD86 CEACAM5
4 bladder carcinoma in situ 10.1 CEACAM5 SMUG1
5 viral infectious disease 10.1 CEACAM5 SMUG1
6 prostate lymphoma 10.1 CEACAM5 SMUG1
7 sclerosing breast papilloma 10.1 CEACAM5 SMUG1
8 myotonic disease 10.1 CD86 CEACAM5
9 ocular motility disease 10.1 CEACAM5 SMUG1
10 tubular adenocarcinoma 10.1 CEACAM5 SMUG1
11 ovarian wilms' cancer 10.1 CEACAM5 SMUG1
12 brain stem cancer 10.0 CEACAM5 SMUG1
13 uterine corpus endometrial stromal sarcoma 10.0 CEACAM5 SMUG1
14 ulcer of lower limbs 10.0 CEACAM5 SMUG1
15 elephantiasis 10.0 CEACAM5 SMUG1
16 hypertropia 10.0 CEACAM5 SMUG1
17 bulbar polio 10.0 CEACAM5 SMUG1
18 skin sarcoma 10.0 CEACAM5 ERBB2
19 rectum sarcoma 10.0 CEACAM5 SMUG1
20 infiltrating angiolipoma 10.0 CEACAM5 ERBB2
21 gastrointestinal system cancer 10.0 CEACAM5 ERBB2
22 novak syndrome 9.9 ERBB2 SMUG1
23 benign shuddering attacks 9.9 CEACAM5 SMUG1
24 fallopian tube adenocarcinoma 9.9 CEACAM5 ERBB2
25 dental caries 9.9 CEACAM5 ERBB2
26 postpartum depression 9.9 ERBB2 SMUG1
27 nasal cavity disease 9.9 CEACAM5 ERBB2
28 odontotrichoungual-digital-palmar syndrome 9.9 CEACAM5 ERBB2
29 retrograde amnesia 9.9 CEACAM5 ERBB2
30 pulmonary fibrosis and/or bone marrow failure, telomere-related, 1 9.9 CEACAM5 ERBB2
31 facial dermatosis 9.8 CEACAM5 ERBB2
32 ocular melanoma 9.8 CEACAM5 ERBB2
33 basaloid squamous cell carcinoma 9.8 CD86 CEACAM5 ERBB2
34 vulva squamous cell carcinoma 9.8 CD86 CEACAM5 ERBB2
35 myotonia congenita 9.8 CD86 CEACAM5 ERBB2
36 solitary plasmacytoma of chest wall 9.8 CEACAM5 ERBB2
37 squamous cell carcinoma 9.8
38 trachea squamous cell carcinoma 9.8 CEACAM5 ERBB2 SMUG1
39 bardet-biedl syndrome 9.8 CEACAM5 ERBB2 SMUG1
40 malignant pleural solitary fibrous tumor 9.8 CEACAM5 ERBB2 SMUG1
41 proctitis 9.8 CEACAM5 ERBB2 SMUG1
42 nevoid hypermelanosis, linear and whorled 9.7 CEACAM5 ERBB2
43 pulmonary artery choriocarcinoma 9.6 CD86 CEACAM5 ERBB2 SMUG1

Graphical network of the top 20 diseases related to Gallbladder Squamous Cell Carcinoma:



Diseases related to Gallbladder Squamous Cell Carcinoma

Symptoms & Phenotypes for Gallbladder Squamous Cell Carcinoma

UMLS symptoms related to Gallbladder Squamous Cell Carcinoma:


abdominal pain

Drugs & Therapeutics for Gallbladder Squamous Cell Carcinoma

Drugs for Gallbladder Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 70)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Capecitabine Approved, Investigational Phase 3,Phase 2,Phase 1 154361-50-9 60953
2
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
3 Antimetabolites Phase 3,Phase 2,Phase 1
4 Antimetabolites, Antineoplastic Phase 3,Phase 2,Phase 1
5 Liver Extracts Phase 3,Phase 1
6 Adjuvants, Anesthesia Phase 3
7 Analgesics Phase 3
8 Analgesics, Opioid Phase 3
9 Anesthetics Phase 3
10 Anesthetics, General Phase 3
11 Anesthetics, Intravenous Phase 3
12 Central Nervous System Depressants Phase 3
13 Narcotics Phase 3
14 pancreatic polypeptide Phase 3
15 Peripheral Nervous System Agents Phase 3,Phase 1
16 Cola Nutraceutical Phase 3,Phase 1
17
Sorafenib Approved, Investigational Phase 2 284461-73-0 216239 406563
18
Gemcitabine Approved Phase 2,Phase 1 95058-81-4 60750
19
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
20
Niacin Approved, Investigational, Nutraceutical Phase 2 59-67-6 938
21
Nicotinamide Approved, Nutraceutical Phase 2 98-92-0 936
22 Micronutrients Phase 2
23 Nicotinic Acids Phase 2
24 Protein Kinase Inhibitors Phase 2,Phase 1
25 Trace Elements Phase 2
26 Vitamin B Complex Phase 2
27 Vitamins Phase 2
28 Anti-Infective Agents Phase 2,Phase 1
29 Antiviral Agents Phase 2,Phase 1
30 Immunosuppressive Agents Phase 2,Phase 1
31
Erlotinib Hydrochloride Phase 2,Phase 1 183319-69-9 176871
32 Folate Nutraceutical Phase 2
33 Vitamin B3 Nutraceutical Phase 2
34 Vitamin B9 Nutraceutical Phase 2
35
Cetuximab Approved Phase 1 205923-56-4 56842117 2333
36
Carboplatin Approved Phase 1 41575-94-4 10339178 498142 38904
37
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
38
Trastuzumab Approved, Investigational Phase 1 180288-69-1 9903
39
Irinotecan Approved, Investigational Phase 1 97682-44-5, 100286-90-6 60838
40
Cisplatin Approved Phase 1 15663-27-1 84093 441203 2767
41
Pancrelipase Approved Phase 1 53608-75-6
42
Altretamine Approved Phase 1 645-05-6 2123
43
Succinylcholine Approved Phase 1 306-40-1 5314
44
7-hydroxystaurosporine Experimental Phase 1 112953-11-4 72271
45
Camptothecin Experimental Phase 1 7689-03-4
46 Staurosporine Experimental Phase 1 62996-74-1
47
Docetaxel Approved May 1996, Investigational Phase 1 114977-28-5 148124 9877265
48 Antibodies Phase 1
49 Antibodies, Monoclonal Phase 1
50 Immunoglobulins Phase 1

Interventional clinical trials:

(show all 16)
id Name Status NCT ID Phase
1 Capecitabine or Observation After Surgery in Treating Patients With Biliary Tract Cancer Completed NCT00363584 Phase 3
2 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3
3 S0514 Sorafenib in Treating Patients With Unresectable or Metastatic Gallbladder Cancer or Cholangiocarcinoma Completed NCT00238212 Phase 2
4 S0202 Gemcitabine and Capecitabine for Unresectable Locally Advanced Metastatic Gallbladder Cancer or Cholangiocarcinoma Completed NCT00033540 Phase 2
5 Sorafenib Tosylate and Erlotinib Hydrochloride in Treating Patients With Locally Advanced, Unresectable, or Metastatic Gallbladder Cancer or Cholangiocarcinoma Completed NCT01093222 Phase 2
6 Selumetinib and Akt Inhibitor MK-2206 in Treating Patients With Refractory or Advanced Gallbladder or Bile Duct Cancer That Cannot Be Removed By Surgery Withdrawn NCT01859182 Phase 2
7 Erlotinib Hydrochloride and Cetuximab in Treating Patients With Advanced Gastrointestinal Cancer, Head and Neck Cancer, Non-Small Cell Lung Cancer, or Colorectal Cancer Completed NCT00397384 Phase 1
8 Interleukin-12 and Trastuzumab in Treating Patients With Cancer That Has High Levels of HER2/Neu Completed NCT00004074 Phase 1
9 7-Hydroxystaurosporine and Irinotecan Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors or Triple Negative Breast Cancer (Currently Accruing Only Triple-negative Breast Cancer Patients Since 6/8/2007) Completed NCT00031681 Phase 1
10 Capecitabine Combined With Cisplatin in Treating Patients With Locally Advanced or Metastatic Solid Tumors Completed NCT00010023 Phase 1
11 Thalidomide and Docetaxel in Treating Patients With Advanced Cancer Completed NCT00049296 Phase 1
12 MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma Completed NCT00020579 Phase 1
13 Gene Therapy in Treating Patients With Cancer Completed NCT00004178 Phase 1
14 RAV12 in Treating Patients With Metastatic or Recurrent Adenocarcinoma Completed NCT00101972 Phase 1
15 Recombinant EphB4-HSA Fusion Protein With Standard Chemotherapy Regimens in Treating Patients With Advanced or Metastatic Solid Tumors Recruiting NCT02495896 Phase 1
16 OX-40 Protein Expression in the Sentinel Lymph Nodes of Patients With Cancer Completed NCT00900302

Search NIH Clinical Center for Gallbladder Squamous Cell Carcinoma

Genetic Tests for Gallbladder Squamous Cell Carcinoma

Anatomical Context for Gallbladder Squamous Cell Carcinoma

Publications for Gallbladder Squamous Cell Carcinoma

Articles related to Gallbladder Squamous Cell Carcinoma:

id Title Authors Year
1
Gallbladder squamous cell carcinoma in the setting of low-dose methotrexate use. ( 19895533 )
2009

Variations for Gallbladder Squamous Cell Carcinoma

Expression for Gallbladder Squamous Cell Carcinoma

Search GEO for disease gene expression data for Gallbladder Squamous Cell Carcinoma.

Pathways for Gallbladder Squamous Cell Carcinoma

Pathways related to Gallbladder Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.69 CD86 CEACAM5

GO Terms for Gallbladder Squamous Cell Carcinoma

Cellular components related to Gallbladder Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 basolateral plasma membrane GO:0016323 8.62 CEACAM5 ERBB2

Biological processes related to Gallbladder Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol-mediated signaling GO:0048015 9.16 CD86 ERBB2
2 phosphatidylinositol phosphorylation GO:0046854 8.96 CD86 ERBB2
3 regulation of phosphatidylinositol 3-kinase signaling GO:0014066 8.62 CD86 ERBB2

Molecular functions related to Gallbladder Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 8.62 CD86 ERBB2

Sources for Gallbladder Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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