MCID: GNG005
MIFTS: 36

Gangliocytoma malady

Categories: Rare diseases, Neuronal diseases, Cancer diseases

Aliases & Classifications for Gangliocytoma

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Aliases & Descriptions for Gangliocytoma:

Name: Gangliocytoma 10 45 12 51
 
Ganglioneuroma 36 65

Classifications:



External Ids:

Disease Ontology10 DOID:2426
MeSH36 D005729
NCIt42 C3049, C6934
Orphanet51 251937
UMLS65 C0017075

Summaries for Gangliocytoma

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NIH Rare Diseases:45 Gangliocytoma is a rare type of central nervous system (cns) tumor made up of mature neurons. gangliocytomas may occur in all age groups but most often occur in people between the ages of 10 and 30. the most common site is the temporal lobe of the brain, but they can arise anywhere in the cns including the cerebellum, brainstem, floor of the third ventricle, and spinal cord. they are among the most frequent tumors associated with epilepsy. signs and symptoms may depend on the tumor's location and may include seizures (most commonly); increased brain pressure; endocrine disorders; and focal symptoms. gangliocytomas are generally slow-growing and usually do not become malignant. treatment involves surgical removal of the tumor.click here to view a separate page about dysplastic gangliocytoma of the cerebellum (also called lhermitte-duclose disease). last updated: 5/11/2015

MalaCards based summary: Gangliocytoma, also known as ganglioneuroma, is related to hypoplastic left heart syndrome and ganglioneuroma. An important gene associated with Gangliocytoma is C9orf72 (Chromosome 9 Open Reading Frame 72), and among its related pathways is Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include temporal lobe, brain and spinal cord, and related mouse phenotypes are cellular and normal.

Wikipedia:68 Ganglioglioma is a rare, slow-growing primary central nervous system (CNS) tumor which most frequently... more...

Related Diseases for Gangliocytoma

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Graphical network of the top 20 diseases related to Gangliocytoma:



Diseases related to gangliocytoma

Symptoms for Gangliocytoma

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Drugs & Therapeutics for Gangliocytoma

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Drugs for Gangliocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Irinotecanapproved, investigationalPhase 0104497682-44-5, 100286-90-660838
Synonyms:
(+)-Irinotecan
(4S)-4,11-DIETHYL-4-HYDROXY-3,14-DIOXO-3,4,12,14-TETRAHYDRO-1H-PYRANO[3',4':6,7]INDOLIZINO[1,2-B]QUINOLIN-9-YL 1,4'-BIPIPERIDINE-1'-CARBOXYLATE
(4S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-4,12-dihydro-1H-pyrano[3,4-f]quinolino[2,3-a]indolizin-9-yl 4-piperidylpiperidinecarboxylate
1u65
97682-44-5
AC-7469
AC1L1U0Z
AC1Q6PGI
BRD-K08547377-003-02-4
BSPBio_002346
Bio-0054
Biotecan
Biotecan (TN)
C16641
C33H38N4O6
CHEBI:105985
CHEMBL481
CID60838
CP0
Campothecin-11
Campto
Camptosar
 
Camptosar, Campto, CPT-11, Irinotecan
Camptothecin-11
D08086
DB00762
FT-0083650
HSDB 7607
IRINOTECAN HYDROCHLORIDE Trihydrate
IRINOTECAN, CPT-11
Irinotecan
Irinotecan (INN)
Irinotecan Hcl
Irinotecan Hydrochloride
Irinotecan Hydrochloride Trihydrate
Irinotecan [INN:BAN]
Irinotecan hydrochloride
Irinotecanum
Irinotecanum [INN-Latin]
LS-44589
NCI60_005051
NSC728073
S1198_Selleck
TL8006026
UNII-7673326042
irinotecan
2
Bevacizumabapproved, investigationalPhase 01875216974-75-3
Synonyms:
216974-75-3
Avastin
Avastin (TN)
Bevacizumab
Bevacizumab (genetical recombination)
 
Bevacizumab (genetical recombination) (JAN)
D06409
R-435
anti-VEGF monoclonal antibody
antiVEGF
bevacizumab
3Topoisomerase InhibitorsPhase 04081
4topoisomerase I inhibitorsPhase 01131
5Angiogenesis Modulating AgentsPhase 03611
6Angiogenesis InhibitorsPhase 03688
7Antineoplastic Agents, PhytogenicPhase 04294

Interventional clinical trials:

idNameStatusNCT IDPhase
1Evaluation of FDOPA-PET/MRI in Pediatric Patients With CNS TumorsRecruitingNCT01999270Phase 0
2Prospective Study Registry of Peripheral Neuroblastic Tumours Presenting With Spinal Canal Involvement (SCI)RecruitingNCT02559804

Search NIH Clinical Center for Gangliocytoma


Cochrane evidence based reviews: ganglioneuroma

Genetic Tests for Gangliocytoma

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Anatomical Context for Gangliocytoma

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MalaCards organs/tissues related to Gangliocytoma:

33
Temporal lobe, Brain, Spinal cord, Cerebellum, Lung, Breast, Bone

Animal Models for Gangliocytoma or affiliated genes

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MGI Mouse Phenotypes related to Gangliocytoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053847.7C9orf72, CRH, GFAP, PTEN, TH
2MP:00028737.7CRH, GFAP, PTEN, SYP, TH
3MP:00053867.0C9orf72, CRH, GFAP, PTEN, SYP, TH
4MP:00036316.8C9orf72, CRH, GFAP, PTEN, SYP, TH

Publications for Gangliocytoma

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Articles related to Gangliocytoma:

(show top 50)    (show all 110)
idTitleAuthorsYear
1
Cutaneous Rosai-Dorfman Disease in a Patient with Human Immunodeficiency Virus. (26990470)
2016
2
MMP-2 inhibits PCSK9-induced degradation of the LDL receptor in Hepa1-c1c7 cells. (25613181)
2015
3
Diagnosis and management of a rare case of fetal mediastinal teratoma without non-immunological hydrops. (26472582)
2015
4
Phase 2 BOLD extension study efficacy results for siponimod (BAF312) in patients with relapsing-remitting multiple sclerosis. (25891595)
2014
5
The staining patterns of 53BP1 nuclear foci and 53BP1 mRNA level are associated with cervical cancer progression and metastasis. (24681733)
2014
6
Reprogramming human umbilical cord mesenchymal stromal cells to islet-like cells with the use of in vitro-synthesized pancreatic-duodenal homebox 1 messenger RNA. (25287601)
2014
7
Clinical evidence of field cancerization in patients with oral cavity cancer in a betel quid chewing area. (24882501)
2014
8
Patterns of physical growth and dental development in Jordanian children and adolescents with thalassemia major. (23485604)
2013
9
Metastasis of renal cell carcinoma to the duodenal papilla. (24122316)
2013
10
Palliative management for patients with subacute obstruction and stage IV unresectable rectosigmoid cancer: colostomy versus endoscopic stenting: final results of a prospective randomized trial. (22575396)
2012
11
Myositis ossificans traumatica of the temporalis muscle: a case report and diagnostic considerations. (21938392)
2012
12
Anti-phospholipid antibodies contribute to arteriosclerosis in patients with systemic lupus erythematosus through induction of tissue factor expression and cytokine production from peripheral blood mononuclear cells. (22196362)
2012
13
The binding affinity and molecular basis of the structure-binding relationship between urinary Tamm-Horsfall glycoprotein and tumor necrosis factor-I+. (23060289)
2012
14
Differentially co-expressed interacting protein pairs discriminate samples under distinct stages of HIV type 1 infection. (22784566)
2011
15
Neisseria meningitidis Opc invasin binds to the sulphated tyrosines of activated vitronectin to attach to and invade human brain endothelial cells. (20502634)
2010
16
The relationship of amelogenesis imperfecta and nephrocalcinosis syndrome. (19680205)
2009
17
Identification of essential residues of human alpha-L-fucosidase and tests of its mechanism. (19072333)
2009
18
Medium-dose ultraviolet (UV) A1 vs. narrowband UVB phototherapy in atopic eczema: a randomized crossover study. (19120333)
2009
19
Effects of methylphenidate on quality of life in children with both developmental coordination disorder and ADHD. (18352997)
2008
20
ALOX5AP variants are associated with in-stent restenosis after percutaneous coronary intervention. (18374923)
2008
21
The expression and role of glucose transporter-1 in infantile hemangioma]. (17554865)
2007
22
Ulceroglandular tularemia in a nonendemic area. (17396737)
2007
23
The clinical spectrum of acute graft-versus-host disease. (16412786)
2006
24
Inhibitors of TACE and Caspase-1 as anti-inflammatory drugs. (16378499)
2005
25
Early onset, non-progressive, mild cerebellar ataxia co-segregating with a familial balanced translocation t(8;20)(p22;q13). (14985396)
2004
26
Serotonin transporter gene promoter (5-HTTLPR) and intron 2 (VNTR) polymorphisms in Croatian suicide victims. (14573315)
2003
27
Complete remission of minimal change nephrotic syndrome with type 2 diabetes mellitus treated by microemulsion formulation of cyclosporin and fluvastatin]. (11974950)
2002
28
Dopamine increases glial cell line-derived neurotrophic factor in human fetal astrocytes. (11180511)
2001
29
Cystadenoma of the liver without mesenchymal stroma in a female following hormonal therapy for acne. (18332923)
2001
30
Single amino acid substitutions in conserved extracellular domains of E-cadherin differ in their functional consequences. (11846558)
2001
31
Insulin-like 3/relaxin-like factor gene mutations are associated with cryptorchidism. (11095425)
2000
32
Interference of proteins involved in the cytoplasmic sequestration of p53 with human papillomavirus E6-mediated degradation. (10029413)
1999
33
An outbreak of West Nile fever among migrants in Kisangani, Democratic Republic of Congo. (10674664)
1999
34
Content and distribution of noncollagenous matrix proteins in bone and cementum: relationship to speed of formation and collagen packing density. (10441531)
1999
35
Isolation and characterization of rat sperm tail outer dense fibres and comparison with rabbit and human spermatozoa using a polyclonal antiserum. (10615260)
1999
36
CD30 expression identifies a functional alloreactive human T-lymphocyte subset. (9603174)
1998
37
The spatial dynamics of prion disease. (9881479)
1998
38
The small heat shock protein hsp27 increases invasiveness but decreases motility of breast cancer cells. (9702938)
1997
39
Pombe Cdc5-related protein. A putative human transcription factor implicated in mitogen-activated signaling. (9038199)
1997
40
The role of EKLF in human beta-globin gene competition. (8918890)
1996
41
Midcervical central cord syndrome: numb and clumsy hands due to midline cervical disc protrusion at the C3-4 intervertebral level. (7745411)
1995
42
Effects of type I-interferons on human thyroid epithelial cells derived from normal and tumour tissue. (7824050)
1994
43
Oedema in patients with Addison's disease on replacement therapy: glucocorticoid excess and mineralocorticoid deficiency? (7922296)
1994
44
Intrahepatic cholestasis of pregnancy, worsening after dexamethasone. (7980318)
1994
45
Trichotillomania. (8306645)
1993
46
Corneal disease. (1658655)
1991
47
Regional distribution of pyridoxal-5'-phosphate in developing and mature brains and its depletion in pyridoxine deficiency. (24272326)
1977
48
Premenstrual tension resembling relapse into depression or psychosis. (18747642)
1976
49
Growth pattern in a boy with thyroxine-binding globulin deficiency. (4623427)
1972
50
A simple diagnostic method in uro-genital trichomoniasis. (5655997)
1968

Variations for Gangliocytoma

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Cosmic variations for Gangliocytoma:

7 (show top 50)    (show all 65)
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
1COSM476BRAFcentral nervous system,brain,other,ganglioglioma3
2COSM476BRAFcentral nervous system,brain,other,ganglioglioma3
3COSM476BRAFcentral nervous system,brain,other,ganglioglioma3
4COSM476BRAFcentral nervous system,brainstem,other,ganglioglioma3
5COSM476BRAFcentral nervous system,brain,other,ganglioglioma3
6COSM476BRAFcentral nervous system,brainstem,other,ganglioglioma3
7COSM476BRAFcentral nervous system,brain,other,ganglioglioma3
8COSM476BRAFcentral nervous system,brain,other,ganglioglioma3
9COSM476BRAFcentral nervous system,brain,other,ganglioglioma3
10COSM476BRAFcentral nervous system,brain,other,ganglioglioma3
11COSM476BRAFcentral nervous system,brainstem,other,ganglioglioma3
12COSM476BRAFcentral nervous system,brain,other,ganglioglioma3
13COSM476BRAFcentral nervous system,brain,other,ganglioglioma3
14COSM476BRAFcentral nervous system,brainstem,other,ganglioglioma3
15COSM476BRAFcentral nervous system,brain,other,ganglioglioma3
16COSM476BRAFcentral nervous system,brainstem,other,ganglioglioma3
17COSM476BRAFcentral nervous system,brain,other,ganglioglioma3
18COSM476BRAFcentral nervous system,brainstem,other,ganglioglioma3
19COSM476BRAFcentral nervous system,brain,other,ganglioglioma3
20COSM476BRAFcentral nervous system,brain,other,ganglioglioma3
21COSM476BRAFcentral nervous system,brainstem,other,ganglioglioma3
22COSM476BRAFcentral nervous system,brainstem,other,ganglioglioma3
23COSM476BRAFcentral nervous system,brain,other,ganglioglioma3
24COSM476BRAFcentral nervous system,brain,other,ganglioglioma3
25COSM476BRAFcentral nervous system,brain,other,ganglioglioma3
26COSM476BRAFcentral nervous system,brain,other,ganglioglioma3
27COSM476BRAFcentral nervous system,brain,other,ganglioglioma3
28COSM476BRAFcentral nervous system,brainstem,other,ganglioglioma3
29COSM476BRAFcentral nervous system,brainstem,other,ganglioglioma3
30COSM476BRAFcentral nervous system,brainstem,other,ganglioglioma3
31COSM476BRAFcentral nervous system,brain,other,ganglioglioma3
32COSM476BRAFcentral nervous system,brain,other,ganglioglioma3
33COSM476BRAFcentral nervous system,brain,other,ganglioglioma3
34COSM476BRAFcentral nervous system,brainstem,other,ganglioglioma3
35COSM476BRAFcentral nervous system,brain,other,ganglioglioma3
36COSM476BRAFcentral nervous system,brain,other,ganglioglioma3
37COSM476BRAFcentral nervous system,brain,other,ganglioglioma3
38COSM476BRAFcentral nervous system,temporal lobe,other,ganglioglioma3
39COSM476BRAFcentral nervous system,brainstem,other,ganglioglioma3
40COSM476BRAFcentral nervous system,temporal lobe,other,ganglioglioma3
41COSM476BRAFcentral nervous system,brain,other,ganglioglioma3
42COSM476BRAFcentral nervous system,temporal lobe,other,ganglioglioma3
43COSM476BRAFcentral nervous system,brain,other,ganglioglioma3
44COSM476BRAFcentral nervous system,brain,other,ganglioglioma3
45COSM476BRAFcentral nervous system,brain,other,ganglioglioma3
46COSM476BRAFcentral nervous system,brain,other,ganglioglioma3
47COSM476BRAFcentral nervous system,brainstem,other,ganglioglioma3
48COSM476BRAFcentral nervous system,brain,other,ganglioglioma3
49COSM476BRAFcentral nervous system,brain,other,ganglioglioma3
50COSM476BRAFcentral nervous system,brainstem,other,ganglioglioma3

Expression for genes affiliated with Gangliocytoma

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Search GEO for disease gene expression data for Gangliocytoma.

Pathways for genes affiliated with Gangliocytoma

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Pathways related to Gangliocytoma according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
18.5GFAP, SYP, TH

GO Terms for genes affiliated with Gangliocytoma

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Biological processes related to Gangliocytoma according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1response to zinc ionGO:00100439.8PTEN, TH
2response to etherGO:00454729.7CRH, TH
3response to corticosteroneGO:00514129.7CRH, TH
4response to ethanolGO:00454719.7CRH, PTEN
5response to immobilization stressGO:00359029.6CRH, TH
6response to organic cyclic compoundGO:00140709.5PTEN, TH
7synaptic transmission, dopaminergicGO:00019639.4CRH, TH
8memoryGO:00076139.4PTEN, TH
9long-term synaptic potentiationGO:00602919.2CRH, PTEN
10response to drugGO:00424939.0CRH, PTEN, TH

Sources for Gangliocytoma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet