MCID: GNG005
MIFTS: 51

Gangliocytoma malady

Rare diseases, Neuronal diseases, Cancer diseases categories

Summaries for Gangliocytoma

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44NIH Rare Diseases, 66Wikipedia, 34MalaCards
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NIH Rare Diseases:44 Gangliocytoma is aĀ rare tumor of ganglia-type cells, which are groups of nerve cells in the brain. gangliocytomas can happen at any age but most often appear between the age of 10 and 30 years. signs and symptoms of this condition are a long history of recurring seizures and increased brain pressure. typically, these tumors do not become cancerous. treatment involvesĀ surgical removal of the tumor. radiation may be necesary if the entire tumorĀ can not be removed.Ā  last updated: 7/25/2012

MalaCards: Gangliocytoma, also known as ganglioneuroblastoma, is related to ganglioneuroma and pheochromocytoma. An important gene associated with Gangliocytoma is SYP (synaptophysin). The compounds betamethasone and l-amino acid have been mentioned in the context of this disorder. Affiliated tissues include brain, cerebellum and pituitary, and related mouse phenotypes are tumorigenesis and no phenotypic analysis.

Wikipedia:66 Ganglioglioma is a tumour that arises from ganglion cells in the central nervous system. Gangliogliomas... more...

Aliases & Classifications for Gangliocytoma

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 50Orphanet, 63UMLS, 41NCIt, 36MeSH, 59SNOMED-CT, 60SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

gangliocytoma 9 44 11 50 63
ganglioneuroblastoma 44
ganglioneuroma 44


External Ids:

Disease Ontology9 DOID:2426
NCIt41 C6934, C3049
MeSH36 D005729
SNOMED-CT via Orphanet60 128919000

Related Diseases for Gangliocytoma

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Gangliocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 162)
idRelated DiseaseScoreTop Affiliating Genes
1ganglioneuroma31.8SYP, PTEN, TH, POMC
2pheochromocytoma30.9TH, POMC, SYP
3pituitary adenoma30.8POMC, SYP
4ganglioneuroblastoma30.8TH, SYP
5paraganglioma30.7SYP, TH
6ganglioglioma30.4SYP, TH, PVALB
7hypertension30.3POMC, TH
8dementia30.2PVALB, SYP, TH
9cushing's syndrome30.1POMC, SYP
10oligodendroglioma30.0SYP, PTEN
11neuroendocrine tumor30.0POMC, SYP
12meningioma29.9PTEN, SYP
13neuroblastoma29.9TH, SYP
14adrenocortical carcinoma29.9POMC, SYP
15tuberous sclerosis29.9PTEN, SYP
16adenoma10.6
17neurofibromatosis10.5
18mediastinitis10.5
19cutaneous ganglioneuroma10.5
20cervicitis10.5
21acromegaly10.4
22diarrhea10.3
23nodular ganglioneuroblastoma10.3
24hirschsprung disease ganglioneuroblastoma10.3
25malignant peripheral nerve sheath tumor10.3
26ataxia10.3
27prolactinoma10.3
28cowden disease10.3
29cerebritis10.3
30phaeochromocytoma10.2
31peripheral nervous system ganglioneuroblastoma10.2
32mediastinum ganglioneuroblastoma10.2
33medulloblastoma10.2
34neurofibroma10.2
35pancreatitis10.2
36multiple endocrine neoplasia10.2
37adrenal gland ganglioneuroblastoma10.2
38paraneoplastic syndromes10.2
39duodenitis10.1
40choroiditis10.1
41hepatitis10.1
42leukemia10.1
43turner syndrome10.1
44astrocytoma10.1
45ependymoma10.1SYP
46adrenal carcinoma10.1POMC
47giant cell glioblastoma10.1PTEN
48intermixed schwannian stroma-rich ganglioneuroblastoma10.1
49stroma-dominant and stroma-poor composite ganglioneuroblastoma10.1
50schwannian stroma-rich and stroma-poor composite ganglioneuroblastoma10.1

Graphical network of the top 20 diseases related to Gangliocytoma:



Diseases related to gangliocytoma

Symptoms for Gangliocytoma

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Drugs & Therapeutics for Gangliocytoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Gangliocytoma

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Genetic Tests for Gangliocytoma

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Anatomical Context for Gangliocytoma

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34MalaCards
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MalaCards organs/tissues related to Gangliocytoma:

34
Brain, Cerebellum, Pituitary, Spinal cord, Pineal, Cortex, Parietal lobe, Pons, Medulla oblongata

Animal Models for Gangliocytoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Gangliocytoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6PTEN, POMC, TH
2MP:00030128.3TH, POMC, PVALB, SYP
3MP:00053868.1PVALB, POMC, PTEN, TH
4MP:00028738.0SYP, PTEN, PVALB, TH
5MP:00036317.6POMC, SYP, PTEN, TH, PVALB

Publications for Gangliocytoma

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Sources:
53PubMed
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Articles related to Gangliocytoma:

(show top 50)    (show all 103)
idTitleAuthorsYear
1
Cushing's disease due to mixed pituitary adenoma-gangliocytoma of the posterior pituitary gland presenting with Aspergillus sp. sinus infection. (23611590)
2013
2
Gangliocytoma of the medulla oblongata demonstrating high tracer uptake on positron emission tomography. (21732072)
2012
3
Combined gangliocytoma and non-functioning pituitary adenoma of the pituitary gland. (22824692)
2012
4
Lhermitte-Duclos disease (dysplastic gangliocytoma of the cerebellum) as a component of Cowden syndrome. (22499315)
2012
5
Intramedullary gangliocytoma with calcification and multiple intramedullary cysts. (22538840)
2012
6
Unusual presentation in adult medulloblastomas: imaging features mimicking cerebellar dysplastic gangliocytoma (Lhermitte-Duclos disease). (23135053)
2012
7
Direct correlation between the facial nerve nucleus and hemifacial seizures associated with a gangliocytoma of the floor of the fourth ventricle: a case report. (22050334)
2011
8
Assessing a dysplastic cerebellar gangliocytoma (Lhermitte-Duclos disease) with 7T MR imaging. (20191074)
2010
9
Medulloblastoma with extensive nodularity undergoing post-therapeutic maturation to a gangliocytoma: a case report and literature review. (21389751)
2010
10
From glioblastoma to gangliocytoma: an unforeseen but welcome shift in biological behavior. (19877783)
2009
11
Cerebellar gangliocytoma presenting with hemifacial spasms: clinical report, literature review and possible mechanisms. (18509586)
2008
12
An unusual association of a sellar gangliocytoma with a prolactinoma. (17440820)
2008
13
Ectopic recurrence of dysplastic gangliocytoma of the cerebellum (Lhermitte-Duclos disease): a case report. (18095141)
2007
14
Pathologic quiz case: an unusual cause of acromegaly. Intrasellar gangliocytoma. (15737044)
2005
15
Acromegaly due to a growth hormone-releasing hormone-secreting intracranial gangliocytoma. (15887863)
2005
16
Radiology case of the month. Gait disturbance. Lhermitte-Duclos disease (dysplastic gangliocytoma of the cerebellum). (15554090)
2004
17
Lhermitte-Duclos disease (dysplastic cerebellar gangliocytoma): a malformation, hamartoma or neoplasm? (11886354)
2002
18
Malignant transformation of a gangliocytoma/ganglioglioma into a glioblastoma multiforme: a molecular genetic analysis. Case report. (11453385)
2001
19
Mixed pituitary adenoma-gangliocytoma in a female albino rat. (11307628)
2001
20
Pituitary gangliocytoma-adenoma presenting with acromegaly: response to treatment. (11295968)
2001
21
Supratentorial gangliocytoma mimicking extra-axial tumor: a report of two cases. (11752979)
2001
22
Lhermitte-Duclos disease (Dysplastic gangliocytoma of the cerebellum). (11516554)
2001
23
Gangliocytoma of the spinal cord: a case report. (11373931)
2001
24
Anaplastic gangliocytoma with eosinophilic cytoplasmic granules in a cow. (10487247)
1999
25
Lhermitte-Duclos disease (cerebellar gangliocytoma). (8969359)
1996
26
Malignant occipital astrocytoma in a patient with Lhermitte-Duclos disease (cerebellar dysplastic gangliocytoma). (8672269)
1996
27
Gangliocytoma of the cervicothoracic spinal cord. (7611066)
1995
28
The striated cerebellum: an MR imaging sign in Lhermitte-Duclos disease (dysplastic gangliocytoma). (7862965)
1995
29
Dysplastic gangliocytoma of the cerebellum (Lhermitte-Duclos disease). (7656495)
1995
30
Dysplastic gangliocytoma of the cerebellum (Lhermitte-Duclos disease) and its relation to the multiple hamartoma syndrome (Cowden disease). (7964980)
1994
31
Cerebral and cerebellar gangliocytomas: a morphological study of nine cases. (7810295)
1994
32
MRI of gangliocytoma of cerebellum and spinal cord. (8491919)
1993
33
Cushing's disease in a child caused by a corticotropin-releasing hormone-secreting intrasellar gangliocytoma associated with an adrenocorticotropic hormone-secreting pituitary adenoma. (8264895)
1993
34
Parvalbumin and calbindin D-28K immunoreactivity in central ganglioglioma and dysplastic gangliocytoma of the cerebellum. Report of two cases. (8416231)
1993
35
Intramedullary secretory gangliocytoma. (1767634)
1991
36
Mixed pituitary adenoma and gangliocytoma associated with acromegaly--case report. (1703643)
1990
37
Lhermitte-Duclos disease (dysplastic gangliocytoma of the cerebellum). Report of a case and review of the literature. (2239379)
1990
38
Gastrin in a hypothalamic gangliocytoma of an acromegalic patient. (2347089)
1990
39
Dysplastic gangliocytoma and intractable partial seizures in childhood. (2927689)
1989
40
Gangliocytoma of the cerebellum: ultrastructure and immunohistochemistry. (3362326)
1988
41
Magnetic resonance imaging in the diagnosis and treatment of Lhermitte-Duclos disease (dysplastic gangliocytoma of the cerebellum). (3185886)
1988
42
Dysplastic gangliocytoma. (3419579)
1988
43
Cerebral gangliocytoma. An ultrastructural study. (2823521)
1987
44
Computerized tomographic (CT) and magnetic resonance imaging (MRI) appearance of a cerebral gangliocytoma. (3564519)
1987
45
Orthostatic hypotension from a cerebellar gangliocytoma (Lhermitte-Duclos disease). Case report. (3723183)
1986
46
Gangliocytoma of the pineal body. A case report and review of the literature. (3872555)
1985
47
Clinical and pathological study of dysplastic gangliocytoma. Case report. (7252559)
1981
48
Gangliocytoma of third ventricle: hyperphagia, somnolence, and dementia. (6955631)
1981
49
Cerebellar gangliocytoma dysplasticum in an infant. (724022)
1978
50
Diffuse amyelinic cerebellar gangliocytoma. Report of case verified at autopsy. (13696023)
1960

Variations for Gangliocytoma

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Expression for genes affiliated with Gangliocytoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gangliocytoma

Search GEO for disease gene expression data for Gangliocytoma.

Pathways for genes affiliated with Gangliocytoma

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Compounds for genes affiliated with Gangliocytoma

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 62Tocris Bioscience, 25HMDB, 30IUPHAR, 3BitterDB
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Compounds related to Gangliocytoma according to GeneCards/GeneDecks:

(show all 48)
idCompoundScoreTop Affiliating Genes
1betamethasone46 1211.0SYP, POMC
2l-amino acid469.9SYP, TH
3maoa469.9TH, POMC
4amphetamine46 52 1211.8TH, POMC
5ganciclovir46 1210.8TH, POMC
6opiate469.8TH, POMC
7hematoxylin469.8PTEN, SYP
8progestin469.7POMC, TH
9corticosterone46 62 2511.6POMC, TH
10ether46 5210.6PVALB, POMC
11catecholamine469.5SYP, POMC, TH
125-hydroxytryptamine469.5TH, SYP, POMC
13cocaine46 1210.5POMC, TH
14methamphetamine46 52 1211.5TH, PVALB
15norepinephrine46 25 1211.5TH, POMC, SYP
16silver469.5PVALB, SYP
17vincristine46 52 1211.5PTEN, POMC
18forskolin46 52 1211.4TH, SYP, POMC
19glutamine469.4SYP, POMC, TH
20tetrodotoxin46 62 3011.4PVALB, TH
21estradiol46 25 1211.3SYP, PTEN, POMC
22cyclic amp46 2510.2SYP, PTEN, TH
23progesterone46 30 62 25 1213.2POMC, SYP, PTEN
24dexamethasone46 52 30 1212.2SYP, POMC, TH
25steroid469.2POMC, PTEN, SYP
26kainate46 3010.1PVALB, TH, SYP
27choline46 25 1211.1TH, SYP, PVALB
28nmda46 3010.1PVALB, SYP, TH
29clozapine46 30 52 1212.1POMC, PVALB, TH
30histamine46 30 2511.1TH, PVALB, SYP
31ethanol46 52 25 1212.0PVALB, SYP, PTEN
32h2o2468.9POMC, PTEN, TH, SYP
33testosterone46 62 25 1211.9SYP, POMC, PTEN, TH
34vegf468.9POMC, PTEN, SYP, TH
35magnesium46 25 1210.9PVALB, SYP, PTEN
36haloperidol46 52 30 3 1212.7PVALB, TH, POMC, SYP
37formaldehyde46 259.7POMC, TH, PVALB, SYP
38gaba468.7POMC, TH, PVALB, SYP
39acetylcholine46 52 30 25 1212.7TH, POMC, SYP, PVALB
40dopamine46 30 25 1211.7POMC, TH, SYP, PVALB
41glutamate468.6TH, PVALB, SYP
42nitric oxide46 25 1210.6PTEN, PVALB, SYP
43alanine468.6PTEN, TH, POMC
44serine468.5PTEN, POMC, SYP, PVALB
45aspartate468.5TH, PTEN, POMC, PVALB
46tyrosine468.4PVALB, SYP, TH, PTEN
47paraffin468.1SYP, POMC, PTEN, TH, PVALB
48estrogen468.1POMC, PTEN, TH, PVALB, SYP

GO Terms for genes affiliated with Gangliocytoma

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17Gene Ontology
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Cellular components related to Gangliocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuron projectionGO:0430059.3PTEN, TH
2cytoplasmic side of plasma membraneGO:0098989.2PTEN, TH
3cytoplasmGO:0057377.2PVALB, POMC, MPRIP, PTEN, TH

Biological processes related to Gangliocytoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1response to zinc ionGO:0100439.5PTEN, TH
2social behaviorGO:0351769.4PTEN, TH
3memoryGO:0076139.4PTEN, TH
4response to estradiolGO:0323559.3TH, PTEN
5heart developmentGO:0075079.3PTEN, TH
6locomotory behaviorGO:0076269.2PTEN, TH
7response to ethanolGO:0454719.0PTEN, TH

Products for genes affiliated with Gangliocytoma

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Sources for Gangliocytoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet