MCID: GNG005
MIFTS: 47

Gangliocytoma malady

Neuronal diseases, Cancer diseases categories

Summaries for Gangliocytoma

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Gangliocytoma is a rare tumor of ganglia-type cells, which are groups of nerve cells in the brain. gangliocytomas can happen at any age but most often appear between the age of 10 and 30 years. signs and symptoms of this condition are a long history of recurring seizures and increased brain pressure. typically, these tumors do not become cancerous. treatment involves surgical removal of the tumor. radiation may be necesary if the entire tumor can not be removed.  last updated: 7/25/2012

MalaCards: Gangliocytoma, also known as ganglioneuroblastoma, is related to ganglioneuroblastoma and adenoma. An important gene associated with Gangliocytoma is SYP (synaptophysin). The compounds l-amino acid and betamethasone have been mentioned in the context of this disorder. Affiliated tissues include brain, cerebellum and pituitary, and related mouse phenotypes are no phenotypic analysis and normal.

Wikipedia:63 Ganglioglioma is a tumour that arises from ganglion cells in the central nervous system. Gangliogliomas... more...

Aliases & Classifications for Gangliocytoma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

gangliocytoma 8 42 10 48 60
ganglioneuroblastoma 42
ganglioneuroma 42


External Ids:

Disease Ontology8 DOID:2426
MeSH34 D005729
NCIt39 C6934, C3049
SNOMED-CT via Orphanet57 128919000

Related Diseases for Gangliocytoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Gangliocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 168)
idRelated DiseaseScoreTop Affiliating Genes
1ganglioneuroblastoma31.5SYP, TH
2adenoma30.8POMC, SYP
3pituitary adenoma30.7POMC, SYP
4ganglioneuroma30.6PTEN, TH, POMC, SYP
5pheochromocytoma30.4SYP, POMC, TH
6ganglioglioma30.3TH, SYP, PVALB
7adrenal adenoma30.3POMC, SYP
8neuroendocrine tumor30.0POMC, SYP
9dementia30.0TH, SYP, PVALB
10hypokalemia30.0POMC
11paraganglioma30.0SYP, TH
12cushing's syndrome30.0POMC, SYP
13neuroblastoma29.8TH, SYP
14neurofibroma29.8SYP
15adrenocortical carcinoma29.8SYP, POMC
16tuberous sclerosis29.7PTEN, SYP
17cutaneous ganglioneuroma10.4
18cerebellar disease10.4
19diarrhea10.4
20nodular ganglioneuroblastoma10.3
21acromegaly10.3
22mediastinum ganglioneuroblastoma10.3
23adrenal gland ganglioneuroblastoma10.3
24hirschsprung disease ganglioneuroblastoma10.3
25cowden disease10.3
26malignant peripheral nerve sheath tumor10.2
27peripheral nervous system ganglioneuroblastoma10.2
28mediastinitis10.2
29prolactinoma10.2
30cerebritis10.2
31syndromic diarrhea10.2
32medulloblastoma10.1
33differentiating neuroblastoma10.1
34cervicitis10.1
35choroiditis10.1
36duodenitis10.1
37astrocytoma10.1
38cerebellar medulloblastoma10.1
39neurofibromatosis10.0
40intermixed schwannian stroma-rich ganglioneuroblastoma10.0
41functional diarrhea10.0
42adrenal neuroblastoma10.0
43osteomalacia10.0
44stroma-dominant and stroma-poor composite ganglioneuroblastoma10.0
45schwannian stroma-rich and stroma-poor composite ganglioneuroblastoma10.0
46phaeochromocytoma10.0
47hypertension10.0
48turner syndrome10.0
49appendicitis10.0
50adenocarcinoma10.0

Graphical network of the top 20 diseases related to Gangliocytoma:



Diseases related to gangliocytoma

Clinical Features for Gangliocytoma

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Drugs & Therapeutics for Gangliocytoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Gangliocytoma

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Anatomical Context for Gangliocytoma

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32MalaCards
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MalaCards organs/tissues related to Gangliocytoma:

32
Brain, Cerebellum, Pituitary, Spinal cord, Pineal, Cortex, Parietal lobe, Pons, Medulla oblongata

Animal Models for Gangliocytoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Gangliocytoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.2POMC, PVALB, SYP, TH
2MP:00028738.2PTEN, TH, SYP, PVALB
3MP:00036317.3PTEN, PVALB, SYP, POMC, TH

Publications for Gangliocytoma

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50PubMed
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Articles related to Gangliocytoma:

(show top 50)    (show all 104)
idTitleAuthorsYear
1
Cushing's disease due to mixed pituitary adenoma-gangliocytoma of the posterior pituitary gland presenting with Aspergillus sp. sinus infection. (23611590)
2013
2
Lhermitte-Duclos disease (dysplastic gangliocytoma of the cerebellum) as a component of Cowden syndrome. (22499315)
2012
3
Intramedullary gangliocytoma with calcification and multiple intramedullary cysts. (22538840)
2012
4
Unusual presentation in adult medulloblastomas: imaging features mimicking cerebellar dysplastic gangliocytoma (Lhermitte-Duclos disease). (23135053)
2012
5
Assessing a dysplastic cerebellar gangliocytoma (Lhermitte-Duclos disease) with 7T MR imaging. (20191074)
2010
6
Collision tumor of anaplastic oligodendroglioma and gangliocytoma: a case report. (19856221)
2009
7
Case 144: Dysplastic cerebellar gangliocytoma (Lhermitte-Duclos disease). (19332858)
2009
8
Subfrontal gangliocytoma masquerading as olfactory groove meningioma. (19234914)
2009
9
Cerebellar gangliocytoma presenting with hemifacial spasms: clinical report, literature review and possible mechanisms. (18509586)
2008
10
Gangliocytoma associated with focal cortical dysplasia in a young-adult: a case report. (18814115)
2008
11
Gangliocytoma of the spinal cord. (17460525)
2007
12
Diffuse cerebral gangliocytoma in an adult with late-onset refractory epilepsy. (17990996)
2007
13
Dysplastic gangliocytoma of the cerebellum (Lhermitte-Duclos disease). (16934474)
2006
14
Acromegaly due to a growth hormone-releasing hormone-secreting intracranial gangliocytoma. (15887863)
2005
15
Intramedullary spinal cord gangliocytoma: case report and a review of the literature. (15739067)
2005
16
Mixed gangliocytoma--adenoma of the sella: case report. (12500383)
2002
17
Mixed pituitary gangliocytoma/adenoma (prolactinoma) with histogenetic implications. (12060349)
2002
18
Malignant transformation of a gangliocytoma/ganglioglioma into a glioblastoma multiforme: a molecular genetic analysis. Case report. (11453385)
2001
19
Mixed pituitary adenoma-gangliocytoma in a female albino rat. (11307628)
2001
20
Pituitary gangliocytoma-adenoma presenting with acromegaly: response to treatment. (11295968)
2001
21
Supratentorial gangliocytoma mimicking extra-axial tumor: a report of two cases. (11752979)
2001
22
Lhermitte-Duclos disease (Dysplastic gangliocytoma of the cerebellum). (11516554)
2001
23
Gangliocytoma of the spinal cord: a case report. (11373931)
2001
24
Prolactin-secreting gangliocytoma. (11453393)
2001
25
Mixed gangliocytoma/pituitary adenoma. (10768636)
2000
26
Malignant occipital astrocytoma in a patient with Lhermitte-Duclos disease (cerebellar dysplastic gangliocytoma). (8672269)
1996
27
Torticollis acquired in late infancy due to a cerebellar gangliocytoma. (8803690)
1996
28
Multifocal neurocytoma/gangliocytoma with extensive leptomeningeal dissemination in the brain and spinal cord. (8772791)
1996
29
Gangliocytoma of the cervicothoracic spinal cord. (7611066)
1995
30
Dysplastic gangliocytoma of the cerebellum (Lhermitte-Duclos disease) and its relation to the multiple hamartoma syndrome (Cowden disease). (7964980)
1994
31
Cerebral and cerebellar gangliocytomas: a morphological study of nine cases. (7810295)
1994
32
Cushing's disease in a child caused by a corticotropin-releasing hormone-secreting intrasellar gangliocytoma associated with an adrenocorticotropic hormone-secreting pituitary adenoma. (8264895)
1993
33
Parvalbumin and calbindin D-28K immunoreactivity in central ganglioglioma and dysplastic gangliocytoma of the cerebellum. Report of two cases. (8416231)
1993
34
Dysplastic gangliocytoma of the cerebellum (Lhermitte-Duclos disease)--a case report with review of the literature. (1473839)
1992
35
Dysplastic gangliocytoma (Lhermitte-Duclos disease): CT and MR imaging. (1408448)
1992
36
Intramedullary secretory gangliocytoma. (1767634)
1991
37
Studies with the Golgi method in central gangliogliomas and dysplastic gangliocytoma of the cerebellum (Lhermitte-Duclos disease). (1724930)
1990
38
Intrasellar gangliocytoma containing gastrin and growth hormone-releasing hormone associated with a growth hormone-secreting pituitary adenoma. (2512034)
1989
39
Neuroendocrine markers in central nervous system neuronal tumors (gangliocytoma and ganglioglioma). (2922988)
1989
40
Gangliocytoma of the cerebellum: ultrastructure and immunohistochemistry. (3362326)
1988
41
Clinical and radiological aspects of dysplastic gangliocytoma (Lhermitte-Duclos disease): a report of two cases with review of the literature. (3278250)
1988
42
Orthostatic hypotension from a cerebellar gangliocytoma (Lhermitte-Duclos disease). Case report. (3723183)
1986
43
Hypothalamic gangliocytoma. Selective appearance of neurofibrillary changes, granulovacuolar degeneration, and argentophilic bodies. (3022544)
1986
44
Cushing's disease associated with an intrasellar gangliocytoma producing corticotrophin-releasing factor. (6333843)
1984
45
A Golgi and electron microscopic study of a dysplastic gangliocytoma of the cerebellum. (474077)
1979
46
Cerebellar gangliocytoma dysplasticum in an infant. (724022)
1978
47
Dysplastic gangliocytoma (Lhermitte-Duclos disease) of the cerebellum. Case report. (903815)
1977
48
Diffuse amyelinic cerebellar gangliocytoma. Report of case verified at autopsy. (13696023)
1960
49
Neuroblastoma (malignant gangliocytoma) of the parietal lobe. (14417470)
1960
50
Gangliocytoma myelinicum diffusum of the cerebellar cortex; review of the literature and report of case. (13546803)
1958

Genetic Variations for Gangliocytoma

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Expression for genes affiliated with Gangliocytoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gangliocytoma

Search GEO for disease gene expression data for Gangliocytoma.

Pathways for genes affiliated with Gangliocytoma

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Compounds for genes affiliated with Gangliocytoma

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44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
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Compounds related to Gangliocytoma according to GeneCards/GeneDecks:

(show all 39)
idCompoundScoreTop Affiliating Genes
1l-amino acid449.9TH, SYP
2betamethasone44 1110.9POMC, SYP
3maoa449.9TH, POMC
4amphetamine44 1110.7TH, POMC
5ganciclovir44 1110.7TH, POMC
6hematoxylin449.7PTEN, SYP
7opiate449.6TH, POMC
8catecholamine449.5SYP, POMC, TH
9ether449.5PVALB, POMC
105-hydroxytryptamine449.5SYP, POMC, TH
11methamphetamine44 49 1111.5TH, PVALB
12norepinephrine44 11 2411.4TH, POMC, SYP
13tetrodotoxin44 59 2811.4PVALB, TH
14forskolin44 49 1111.4TH, POMC, SYP
15glutamine449.3SYP, POMC, TH
16silver449.2SYP, PVALB
17estradiol44 11 2411.2SYP, POMC, PTEN
18progestin449.2TH, POMC
19kainate44 2810.2PVALB, SYP, TH
20choline44 11 2411.2TH, SYP, PVALB
21nmda44 2810.1TH, SYP, PVALB
22cyclic amp44 2410.1PTEN, TH, SYP
23histamine44 28 2411.1TH, SYP, PVALB
24clozapine44 28 49 1112.1TH, POMC, PVALB
25ethanol44 49 11 2411.9PVALB, SYP, PTEN
26h2o2448.8SYP, POMC, TH, PTEN
27testosterone44 59 11 2411.8SYP, POMC, TH, PTEN
28vegf448.8SYP, POMC, TH, PTEN
29progesterone44 59 28 11 2412.8SYP, POMC, PTEN
30haloperidol44 28 2 49 1112.7PVALB, SYP, POMC, TH
31formaldehyde44 249.7TH, POMC, SYP, PVALB
32gaba448.7PVALB, SYP, POMC, TH
33acetylcholine44 49 28 11 2412.7TH, POMC, SYP, PVALB
34dopamine44 28 11 2411.7PVALB, SYP, POMC, TH
35magnesium44 11 2410.6PTEN, SYP, PVALB
36aspartate448.4PVALB, POMC, TH, PTEN
37serine448.2PVALB, SYP, POMC, PTEN
38paraffin448.1PTEN, TH, POMC, SYP, PVALB
39estrogen448.1PVALB, SYP, POMC, TH, PTEN

GO Terms for genes affiliated with Gangliocytoma

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16Gene Ontology
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Cellular components related to Gangliocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1internal side of plasma membraneGO:0098989.4PTEN, TH

Biological processes related to Gangliocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1locomotory behaviorGO:0076269.4PTEN, TH
2social behaviorGO:0351769.1PTEN, TH

Products for genes affiliated with Gangliocytoma

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Sources for Gangliocytoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet