MCID: GNG005
MIFTS: 51

Gangliocytoma malady

Rare diseases, Neuronal diseases, Cancer diseases categories
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Summaries for Gangliocytoma

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43NIH Rare Diseases, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Gangliocytoma is a rare tumor of ganglia-type cells, which are groups of nerve cells in the brain. gangliocytomas can happen at any age but most often appear between the age of 10 and 30 years. signs and symptoms of this condition are a long history of recurring seizures and increased brain pressure. typically, these tumors do not become cancerous. treatment involves surgical removal of the tumor. radiation may be necesary if the entire tumor can not be removed.  last updated: 7/25/2012

MalaCards: Gangliocytoma, also known as ganglioneuroblastoma, is related to ganglioneuroma and pheochromocytoma. An important gene associated with Gangliocytoma is SYP (synaptophysin). The compounds betamethasone and l-amino acid have been mentioned in the context of this disorder. Affiliated tissues include brain, cerebellum and pituitary, and related mouse phenotypes are tumorigenesis and no phenotypic analysis.

Wikipedia:65 Ganglioglioma is a tumour that arises from ganglion cells in the central nervous system. Gangliogliomas... more...

Aliases & Classifications for Gangliocytoma

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 49Orphanet, 62UMLS, 40NCIt, 35MeSH, 58SNOMED-CT, 59SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

gangliocytoma 8 43 10 49 62
ganglioneuroblastoma 43
ganglioneuroma 43


External Ids:

Disease Ontology8 DOID:2426
NCIt40 C6934, C3049
MeSH35 D005729
SNOMED-CT via Orphanet59 128919000

Related Diseases for Gangliocytoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Gangliocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 162)
idRelated DiseaseScoreTop Affiliating Genes
1ganglioneuroma31.8SYP, PTEN, TH, POMC
2pheochromocytoma30.9TH, POMC, SYP
3pituitary adenoma30.8POMC, SYP
4ganglioneuroblastoma30.8TH, SYP
5paraganglioma30.7SYP, TH
6ganglioglioma30.4SYP, TH, PVALB
7hypertension30.3POMC, TH
8dementia30.2PVALB, SYP, TH
9cushing's syndrome30.1POMC, SYP
10oligodendroglioma30.0SYP, PTEN
11neuroendocrine tumor30.0POMC, SYP
12meningioma29.9PTEN, SYP
13neuroblastoma29.9TH, SYP
14adrenocortical carcinoma29.9POMC, SYP
15tuberous sclerosis29.9PTEN, SYP
16adenoma10.6
17neurofibromatosis10.5
18mediastinitis10.5
19cutaneous ganglioneuroma10.5
20cervicitis10.5
21acromegaly10.4
22diarrhea10.3
23nodular ganglioneuroblastoma10.3
24hirschsprung disease ganglioneuroblastoma10.3
25malignant peripheral nerve sheath tumor10.3
26ataxia10.3
27prolactinoma10.3
28cowden disease10.3
29cerebritis10.3
30phaeochromocytoma10.2
31peripheral nervous system ganglioneuroblastoma10.2
32mediastinum ganglioneuroblastoma10.2
33medulloblastoma10.2
34neurofibroma10.2
35pancreatitis10.2
36multiple endocrine neoplasia10.2
37adrenal gland ganglioneuroblastoma10.2
38paraneoplastic syndromes10.2
39duodenitis10.1
40choroiditis10.1
41hepatitis10.1
42leukemia10.1
43turner syndrome10.1
44astrocytoma10.1
45ependymoma10.1SYP
46adrenal carcinoma10.1POMC
47giant cell glioblastoma10.1PTEN
48intermixed schwannian stroma-rich ganglioneuroblastoma10.1
49stroma-dominant and stroma-poor composite ganglioneuroblastoma10.1
50schwannian stroma-rich and stroma-poor composite ganglioneuroblastoma10.1

Graphical network of the top 20 diseases related to Gangliocytoma:



Diseases related to gangliocytoma

Symptoms for Gangliocytoma

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Drugs & Therapeutics for Gangliocytoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Gangliocytoma

Search NIH Clinical Center for Gangliocytoma

Genetic Tests for Gangliocytoma

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Anatomical Context for Gangliocytoma

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33MalaCards
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MalaCards organs/tissues related to Gangliocytoma:

33
Brain, Cerebellum, Pituitary, Spinal cord, Pineal, Cortex, Parietal lobe, Pons, Medulla oblongata

Animal Models for Gangliocytoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Gangliocytoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6PTEN, POMC, TH
2MP:00030128.3TH, POMC, PVALB, SYP
3MP:00053868.1PVALB, POMC, PTEN, TH
4MP:00028738.0SYP, PTEN, PVALB, TH
5MP:00036317.6POMC, SYP, PTEN, TH, PVALB

Publications for Gangliocytoma

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52PubMed
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Articles related to Gangliocytoma:

(show top 50)    (show all 103)
idTitleAuthorsYear
1
Cushing's disease due to mixed pituitary adenoma-gangliocytoma of the posterior pituitary gland presenting with Aspergillus sp. sinus infection. (23611590)
2013
2
Gangliocytoma of the medulla oblongata demonstrating high tracer uptake on positron emission tomography. (21732072)
2012
3
Combined gangliocytoma and non-functioning pituitary adenoma of the pituitary gland. (22824692)
2012
4
Lhermitte-Duclos disease (dysplastic gangliocytoma of the cerebellum) as a component of Cowden syndrome. (22499315)
2012
5
Intramedullary gangliocytoma with calcification and multiple intramedullary cysts. (22538840)
2012
6
Unusual presentation in adult medulloblastomas: imaging features mimicking cerebellar dysplastic gangliocytoma (Lhermitte-Duclos disease). (23135053)
2012
7
Direct correlation between the facial nerve nucleus and hemifacial seizures associated with a gangliocytoma of the floor of the fourth ventricle: a case report. (22050334)
2011
8
Assessing a dysplastic cerebellar gangliocytoma (Lhermitte-Duclos disease) with 7T MR imaging. (20191074)
2010
9
Medulloblastoma with extensive nodularity undergoing post-therapeutic maturation to a gangliocytoma: a case report and literature review. (21389751)
2010
10
From glioblastoma to gangliocytoma: an unforeseen but welcome shift in biological behavior. (19877783)
2009
11
Cerebellar gangliocytoma presenting with hemifacial spasms: clinical report, literature review and possible mechanisms. (18509586)
2008
12
An unusual association of a sellar gangliocytoma with a prolactinoma. (17440820)
2008
13
Ectopic recurrence of dysplastic gangliocytoma of the cerebellum (Lhermitte-Duclos disease): a case report. (18095141)
2007
14
Pathologic quiz case: an unusual cause of acromegaly. Intrasellar gangliocytoma. (15737044)
2005
15
Acromegaly due to a growth hormone-releasing hormone-secreting intracranial gangliocytoma. (15887863)
2005
16
Radiology case of the month. Gait disturbance. Lhermitte-Duclos disease (dysplastic gangliocytoma of the cerebellum). (15554090)
2004
17
Lhermitte-Duclos disease (dysplastic cerebellar gangliocytoma): a malformation, hamartoma or neoplasm? (11886354)
2002
18
Malignant transformation of a gangliocytoma/ganglioglioma into a glioblastoma multiforme: a molecular genetic analysis. Case report. (11453385)
2001
19
Mixed pituitary adenoma-gangliocytoma in a female albino rat. (11307628)
2001
20
Pituitary gangliocytoma-adenoma presenting with acromegaly: response to treatment. (11295968)
2001
21
Supratentorial gangliocytoma mimicking extra-axial tumor: a report of two cases. (11752979)
2001
22
Lhermitte-Duclos disease (Dysplastic gangliocytoma of the cerebellum). (11516554)
2001
23
Gangliocytoma of the spinal cord: a case report. (11373931)
2001
24
Anaplastic gangliocytoma with eosinophilic cytoplasmic granules in a cow. (10487247)
1999
25
Lhermitte-Duclos disease (cerebellar gangliocytoma). (8969359)
1996
26
Malignant occipital astrocytoma in a patient with Lhermitte-Duclos disease (cerebellar dysplastic gangliocytoma). (8672269)
1996
27
Gangliocytoma of the cervicothoracic spinal cord. (7611066)
1995
28
The striated cerebellum: an MR imaging sign in Lhermitte-Duclos disease (dysplastic gangliocytoma). (7862965)
1995
29
Dysplastic gangliocytoma of the cerebellum (Lhermitte-Duclos disease). (7656495)
1995
30
Dysplastic gangliocytoma of the cerebellum (Lhermitte-Duclos disease) and its relation to the multiple hamartoma syndrome (Cowden disease). (7964980)
1994
31
Cerebral and cerebellar gangliocytomas: a morphological study of nine cases. (7810295)
1994
32
MRI of gangliocytoma of cerebellum and spinal cord. (8491919)
1993
33
Cushing's disease in a child caused by a corticotropin-releasing hormone-secreting intrasellar gangliocytoma associated with an adrenocorticotropic hormone-secreting pituitary adenoma. (8264895)
1993
34
Parvalbumin and calbindin D-28K immunoreactivity in central ganglioglioma and dysplastic gangliocytoma of the cerebellum. Report of two cases. (8416231)
1993
35
Intramedullary secretory gangliocytoma. (1767634)
1991
36
Mixed pituitary adenoma and gangliocytoma associated with acromegaly--case report. (1703643)
1990
37
Lhermitte-Duclos disease (dysplastic gangliocytoma of the cerebellum). Report of a case and review of the literature. (2239379)
1990
38
Gastrin in a hypothalamic gangliocytoma of an acromegalic patient. (2347089)
1990
39
Dysplastic gangliocytoma and intractable partial seizures in childhood. (2927689)
1989
40
Gangliocytoma of the cerebellum: ultrastructure and immunohistochemistry. (3362326)
1988
41
Magnetic resonance imaging in the diagnosis and treatment of Lhermitte-Duclos disease (dysplastic gangliocytoma of the cerebellum). (3185886)
1988
42
Dysplastic gangliocytoma. (3419579)
1988
43
Cerebral gangliocytoma. An ultrastructural study. (2823521)
1987
44
Computerized tomographic (CT) and magnetic resonance imaging (MRI) appearance of a cerebral gangliocytoma. (3564519)
1987
45
Orthostatic hypotension from a cerebellar gangliocytoma (Lhermitte-Duclos disease). Case report. (3723183)
1986
46
Gangliocytoma of the pineal body. A case report and review of the literature. (3872555)
1985
47
Clinical and pathological study of dysplastic gangliocytoma. Case report. (7252559)
1981
48
Gangliocytoma of third ventricle: hyperphagia, somnolence, and dementia. (6955631)
1981
49
Cerebellar gangliocytoma dysplasticum in an infant. (724022)
1978
50
Diffuse amyelinic cerebellar gangliocytoma. Report of case verified at autopsy. (13696023)
1960

Variations for Gangliocytoma

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Expression for genes affiliated with Gangliocytoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gangliocytoma

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Pathways for genes affiliated with Gangliocytoma

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Compounds for genes affiliated with Gangliocytoma

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Sources:
45Novoseek, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 24HMDB, 29IUPHAR, 3BitterDB
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Compounds related to Gangliocytoma according to GeneCards/GeneDecks:

(show all 48)
idCompoundScoreTop Affiliating Genes
1betamethasone45 1111.0SYP, POMC
2l-amino acid459.9SYP, TH
3maoa459.9TH, POMC
4amphetamine45 51 1111.8TH, POMC
5ganciclovir45 1110.8TH, POMC
6opiate459.8TH, POMC
7hematoxylin459.8PTEN, SYP
8progestin459.7POMC, TH
9corticosterone45 61 2411.6POMC, TH
10ether45 5110.6PVALB, POMC
11catecholamine459.5SYP, POMC, TH
125-hydroxytryptamine459.5TH, SYP, POMC
13cocaine45 1110.5POMC, TH
14methamphetamine45 51 1111.5TH, PVALB
15norepinephrine45 24 1111.5TH, POMC, SYP
16silver459.5PVALB, SYP
17vincristine45 51 1111.5PTEN, POMC
18forskolin45 51 1111.4TH, SYP, POMC
19glutamine459.4SYP, POMC, TH
20tetrodotoxin45 61 2911.4PVALB, TH
21estradiol45 24 1111.3SYP, PTEN, POMC
22cyclic amp45 2410.2SYP, PTEN, TH
23progesterone45 29 61 24 1113.2POMC, SYP, PTEN
24dexamethasone45 51 29 1112.2SYP, POMC, TH
25steroid459.2POMC, PTEN, SYP
26kainate45 2910.1PVALB, TH, SYP
27choline45 24 1111.1TH, SYP, PVALB
28nmda45 2910.1PVALB, SYP, TH
29clozapine45 29 51 1112.1POMC, PVALB, TH
30histamine45 29 2411.1TH, PVALB, SYP
31ethanol45 51 24 1112.0PVALB, SYP, PTEN
32h2o2458.9POMC, PTEN, TH, SYP
33testosterone45 61 24 1111.9SYP, POMC, PTEN, TH
34vegf458.9POMC, PTEN, SYP, TH
35magnesium45 24 1110.9PVALB, SYP, PTEN
36haloperidol45 51 29 3 1112.7PVALB, TH, POMC, SYP
37formaldehyde45 249.7POMC, TH, PVALB, SYP
38gaba458.7POMC, TH, PVALB, SYP
39acetylcholine45 51 29 24 1112.7TH, POMC, SYP, PVALB
40dopamine45 29 24 1111.7POMC, TH, SYP, PVALB
41glutamate458.6TH, PVALB, SYP
42nitric oxide45 24 1110.6PTEN, PVALB, SYP
43alanine458.6PTEN, TH, POMC
44serine458.5PTEN, POMC, SYP, PVALB
45aspartate458.5TH, PTEN, POMC, PVALB
46tyrosine458.4PVALB, SYP, TH, PTEN
47paraffin458.1SYP, POMC, PTEN, TH, PVALB
48estrogen458.1POMC, PTEN, TH, PVALB, SYP

GO Terms for genes affiliated with Gangliocytoma

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16Gene Ontology
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Cellular components related to Gangliocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuron projectionGO:0430059.3PTEN, TH
2cytoplasmic side of plasma membraneGO:0098989.2PTEN, TH
3cytoplasmGO:0057377.2PVALB, POMC, MPRIP, PTEN, TH

Biological processes related to Gangliocytoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1response to zinc ionGO:0100439.5PTEN, TH
2social behaviorGO:0351769.4PTEN, TH
3memoryGO:0076139.4PTEN, TH
4response to estradiolGO:0323559.3TH, PTEN
5heart developmentGO:0075079.3PTEN, TH
6locomotory behaviorGO:0076269.2PTEN, TH
7response to ethanolGO:0454719.0PTEN, TH

Products for genes affiliated with Gangliocytoma

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Sources for Gangliocytoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet