MCID: GNG005
MIFTS: 47

Gangliocytoma malady

Neuronal diseases, Cancer diseases categories

Summaries for Gangliocytoma

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Gangliocytoma is a rare tumor of ganglia-type cells, which are groups of nerve cells in the brain. gangliocytomas can happen at any age but most often appear between the age of 10 and 30 years. signs and symptoms of this condition are a long history of recurring seizures and increased brain pressure. typically, these tumors do not become cancerous. treatment involves surgical removal of the tumor. radiation may be necesary if the entire tumor can not be removed.  last updated: 7/25/2012

MalaCards: Gangliocytoma, also known as ganglioneuroblastoma, is related to ganglioneuroblastoma and adenoma. An important gene associated with Gangliocytoma is SYP (synaptophysin). The compounds l-amino acid and betamethasone have been mentioned in the context of this disorder. Affiliated tissues include brain, cerebellum and pituitary, and related mouse phenotypes are no phenotypic analysis and normal.

Wikipedia:63 Ganglioglioma is a tumour that arises from ganglion cells in the central nervous system. Gangliogliomas... more...

Aliases & Classifications for Gangliocytoma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

gangliocytoma 8 42 10 48 60
ganglioneuroblastoma 42
ganglioneuroma 42


External Ids:

Disease Ontology8 DOID:2426
MeSH34 D005729
NCIt39 C6934, C3049
SNOMED-CT via Orphanet57 128919000

Related Diseases for Gangliocytoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Gangliocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 168)
idRelated DiseaseScoreTop Affiliating Genes
1ganglioneuroblastoma31.5SYP, TH
2adenoma30.8POMC, SYP
3pituitary adenoma30.7POMC, SYP
4ganglioneuroma30.6PTEN, TH, POMC, SYP
5pheochromocytoma30.4SYP, POMC, TH
6ganglioglioma30.3TH, SYP, PVALB
7adrenal adenoma30.3POMC, SYP
8neuroendocrine tumor30.0POMC, SYP
9dementia30.0TH, SYP, PVALB
10hypokalemia30.0POMC
11paraganglioma30.0SYP, TH
12cushing's syndrome30.0POMC, SYP
13neuroblastoma29.8TH, SYP
14neurofibroma29.8SYP
15adrenocortical carcinoma29.8SYP, POMC
16tuberous sclerosis29.7PTEN, SYP
17cutaneous ganglioneuroma10.4
18cerebellar disease10.4
19diarrhea10.4
20nodular ganglioneuroblastoma10.3
21acromegaly10.3
22mediastinum ganglioneuroblastoma10.3
23adrenal gland ganglioneuroblastoma10.3
24hirschsprung disease ganglioneuroblastoma10.3
25cowden disease10.3
26malignant peripheral nerve sheath tumor10.2
27peripheral nervous system ganglioneuroblastoma10.2
28mediastinitis10.2
29prolactinoma10.2
30cerebritis10.2
31syndromic diarrhea10.2
32medulloblastoma10.1
33differentiating neuroblastoma10.1
34cervicitis10.1
35choroiditis10.1
36duodenitis10.1
37astrocytoma10.1
38cerebellar medulloblastoma10.1
39neurofibromatosis10.0
40intermixed schwannian stroma-rich ganglioneuroblastoma10.0
41functional diarrhea10.0
42adrenal neuroblastoma10.0
43osteomalacia10.0
44stroma-dominant and stroma-poor composite ganglioneuroblastoma10.0
45schwannian stroma-rich and stroma-poor composite ganglioneuroblastoma10.0
46phaeochromocytoma10.0
47hypertension10.0
48turner syndrome10.0
49appendicitis10.0
50adenocarcinoma10.0

Graphical network of the top 20 diseases related to Gangliocytoma:



Diseases related to gangliocytoma

Clinical Features for Gangliocytoma

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Drugs & Therapeutics for Gangliocytoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Gangliocytoma

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Genetic Tests for Gangliocytoma

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Anatomical Context for Gangliocytoma

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32MalaCards
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MalaCards organs/tissues related to Gangliocytoma:

32
Brain, Cerebellum, Pituitary, Spinal cord, Cortex, Parietal lobe, Pons, Medulla oblongata, Pineal

Animal Models for Gangliocytoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Gangliocytoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.2TH, POMC, SYP, PVALB
2MP:00028738.2PTEN, TH, SYP, PVALB
3MP:00036317.3PVALB, SYP, POMC, TH, PTEN

Publications for Gangliocytoma

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50PubMed
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Articles related to Gangliocytoma:

(show top 50)    (show all 104)
idTitleAuthorsYear
1
A familial frontotemporal dementia associated with C9orf72 repeat expansion and dysplastic gangliocytoma. (24080172)
2014
2
Gangliocytoma of the medulla oblongata demonstrating high tracer uptake on positron emission tomography. (21732072)
2012
3
Combined gangliocytoma and non-functioning pituitary adenoma of the pituitary gland. (22824692)
2012
4
Ossifying pituitary adenoma co-existing with astrocytoma and pituitary adenoma associated with gangliocytoma: two unusual conditions. (22274987)
2012
5
Acromegaly associated with gangliocytoma. (19789938)
2012
6
Direct correlation between the facial nerve nucleus and hemifacial seizures associated with a gangliocytoma of the floor of the fourth ventricle: a case report. (22050334)
2011
7
Assessing a dysplastic cerebellar gangliocytoma (Lhermitte-Duclos disease) with 7T MR imaging. (20191074)
2010
8
Medulloblastoma with extensive nodularity undergoing post-therapeutic maturation to a gangliocytoma: a case report and literature review. (21389751)
2010
9
Cytomorphologic spectrum of mixed pituitary adenoma-gangliocytomas: a report of two cases. (21053582)
2010
10
From glioblastoma to gangliocytoma: an unforeseen but welcome shift in biological behavior. (19877783)
2009
11
Cerebellar gangliocytoma presenting with hemifacial spasms: clinical report, literature review and possible mechanisms. (18509586)
2008
12
Combined gangliocytoma and prolactinoma of the pituitary gland. (18651251)
2008
13
Pathologic quiz case: an unusual cause of acromegaly. Intrasellar gangliocytoma. (15737044)
2005
14
Radiology case of the month. Gait disturbance. Lhermitte-Duclos disease (dysplastic gangliocytoma of the cerebellum). (15554090)
2004
15
Posterior fossa gangliocytoma with facial nerve invasion: case report. (12806511)
2003
16
Dysplastic gangliocytoma of the cerebellum: rare differential diagnosis in space occupying lesions of the posterior fossa. (12836078)
2003
17
Medulloblastoma or cerebellar dysplastic gangliocytoma (Lhermitte-Duclos disease)? (12504212)
2002
18
Mixed pituitary gangliocytoma/adenoma (prolactinoma) with histogenetic implications. (12060349)
2002
19
Malignant transformation of a gangliocytoma/ganglioglioma into a glioblastoma multiforme: a molecular genetic analysis. Case report. (11453385)
2001
20
Supratentorial gangliocytoma mimicking extra-axial tumor: a report of two cases. (11752979)
2001
21
Anaplastic gangliocytoma with eosinophilic cytoplasmic granules in a cow. (10487247)
1999
22
Gangliocytoma masquerading as a prolactinoma. Case report. (10470826)
1999
23
Gangliocytoma--magnetic resonance imaging characteristics. (9844501)
1998
24
Intrasellar mixed gangliocytoma-adenoma. (9308499)
1997
25
Intrasellar gangliocytoma resembling pituitary adenoma. (9359090)
1997
26
Lhermitte-Duclos disease (cerebellar gangliocytoma). (8969359)
1996
27
Multifocal neurocytoma/gangliocytoma with extensive leptomeningeal dissemination in the brain and spinal cord. (8772791)
1996
28
The striated cerebellum: an MR imaging sign in Lhermitte-Duclos disease (dysplastic gangliocytoma). (7862965)
1995
29
Dysplastic gangliocytoma of the cerebellum (Lhermitte-Duclos disease) and its relation to the multiple hamartoma syndrome (Cowden disease). (7964980)
1994
30
Combined sellar gangliocytoma and pituitary adenoma in acromegaly or Cushing's disease. A report of 3 cases. (7921420)
1994
31
Immunohistochemical study in two cases of dysplastic gangliocytoma of cerebellum (Lhermitte-Duclos disease). (7889336)
1994
32
MRI of gangliocytoma of cerebellum and spinal cord. (8491919)
1993
33
Holoprosencephaly, hamartomatous growth of the cerebrum, dysplastic gangliocytoma of the cerebellum, unique brain anomalies, and renal agenesis in a Brazilian infant born to a diabetic mother: a clinical and pathologic study. (8280891)
1993
34
Recurrent dysplastic cerebellar gangliocytoma (Lhermitte-Duclos disease) presenting with subarachnoid haemorrhage. (1590970)
1992
35
Dysplastic gangliocytoma of the cerebellum (Lhermitte-Duclos disease)--a case report with review of the literature. (1473839)
1992
36
Dysplastic gangliocytoma of cerebellum in a newborn. Diagnosis by ultrasonography and MRI. (1501942)
1992
37
Mixed pituitary adenoma and gangliocytoma associated with acromegaly--case report. (1703643)
1990
38
Lhermitte-Duclos disease (dysplastic gangliocytoma of the cerebellum). Report of a case and review of the literature. (2239379)
1990
39
Dysplastic gangliocytoma and intractable partial seizures in childhood. (2927689)
1989
40
Mixed gangliocytoma-adenoma: a distinct neuroendocrine tumor of the pituitary fossa. (2591950)
1989
41
Intrasellar gangliocytoma containing gastrin and growth hormone-releasing hormone associated with a growth hormone-secreting pituitary adenoma. (2512034)
1989
42
Magnetic resonance imaging in the diagnosis and treatment of Lhermitte-Duclos disease (dysplastic gangliocytoma of the cerebellum). (3185886)
1988
43
Dysplastic gangliocytoma. (3419579)
1988
44
Computerized tomographic (CT) and magnetic resonance imaging (MRI) appearance of a cerebral gangliocytoma. (3564519)
1987
45
Gangliocytoma of the pineal body. A case report and review of the literature. (3872555)
1985
46
Dysplastic gangliocytoma of cerebellum in a newborn. Case report. (6707754)
1984
47
Clinical and pathological study of dysplastic gangliocytoma. Case report. (7252559)
1981
48
Gangliocytoma of third ventricle: hyperphagia, somnolence, and dementia. (6955631)
1981
49
Dysplastic gangliocytoma of the cerebellum--an ultrastructural study. (207069)
1978
50
Gliomas of the brain stem. I. Study of a gangliocytoma of the pons penetrating into the hypothalamic region]. (13079693)
1953

Genetic Variations for Gangliocytoma

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Expression for genes affiliated with Gangliocytoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gangliocytoma

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Pathways for genes affiliated with Gangliocytoma

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Compounds for genes affiliated with Gangliocytoma

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44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
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Compounds related to Gangliocytoma according to GeneCards/GeneDecks:

(show all 39)
idCompoundScoreTop Affiliating Genes
1l-amino acid449.9TH, SYP
2betamethasone44 1110.9POMC, SYP
3maoa449.9TH, POMC
4amphetamine44 1110.7TH, POMC
5ganciclovir44 1110.7TH, POMC
6hematoxylin449.7PTEN, SYP
7opiate449.6TH, POMC
8catecholamine449.5SYP, POMC, TH
9ether449.5PVALB, POMC
105-hydroxytryptamine449.5SYP, POMC, TH
11methamphetamine44 49 1111.5TH, PVALB
12norepinephrine44 11 2411.4TH, POMC, SYP
13tetrodotoxin44 59 2811.4PVALB, TH
14forskolin44 49 1111.4TH, POMC, SYP
15glutamine449.3SYP, POMC, TH
16silver449.2SYP, PVALB
17estradiol44 11 2411.2SYP, POMC, PTEN
18progestin449.2TH, POMC
19kainate44 2810.2PVALB, SYP, TH
20choline44 11 2411.2TH, SYP, PVALB
21nmda44 2810.1TH, SYP, PVALB
22cyclic amp44 2410.1PTEN, TH, SYP
23histamine44 28 2411.1TH, SYP, PVALB
24clozapine44 28 49 1112.1TH, POMC, PVALB
25ethanol44 49 11 2411.9PVALB, SYP, PTEN
26h2o2448.8SYP, POMC, TH, PTEN
27testosterone44 59 11 2411.8SYP, POMC, TH, PTEN
28vegf448.8SYP, POMC, TH, PTEN
29progesterone44 59 28 11 2412.8SYP, POMC, PTEN
30haloperidol44 28 2 49 1112.7PVALB, SYP, POMC, TH
31formaldehyde44 249.7TH, POMC, SYP, PVALB
32gaba448.7PVALB, SYP, POMC, TH
33acetylcholine44 49 28 11 2412.7TH, POMC, SYP, PVALB
34dopamine44 28 11 2411.7PVALB, SYP, POMC, TH
35magnesium44 11 2410.6PTEN, SYP, PVALB
36aspartate448.4PVALB, POMC, TH, PTEN
37serine448.2PVALB, SYP, POMC, PTEN
38paraffin448.1PTEN, TH, POMC, SYP, PVALB
39estrogen448.1PVALB, SYP, POMC, TH, PTEN

GO Terms for genes affiliated with Gangliocytoma

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16Gene Ontology
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Cellular components related to Gangliocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1internal side of plasma membraneGO:0098989.4PTEN, TH

Biological processes related to Gangliocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1locomotory behaviorGO:0076269.4PTEN, TH
2social behaviorGO:0351769.1PTEN, TH

Products for genes affiliated with Gangliocytoma

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Sources for Gangliocytoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet