MCID: GNG004
MIFTS: 60

Ganglioglioma malady

Neuronal diseases, Cancer diseases categories

Summaries for Ganglioglioma

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 A ganglioglioma is a rare type of brain tumor, accounting for approximately 1% of all brain tumors.  gangliogliomas occur when a single cell in the brain starts to divide into more cells, forming a tumor.  this can occur when the cell randomly acquires changes (mutations) in genes that regulate how a cell divides.  most gangliogliomas grow slowly and are considered benign.  however, up to 10% of gangliogliomas may grow more rapidly and become malignant, meaning the tumor affects the surrounding brain tissue.    the main treatment for ganglioglioma is removal of the entire tumor during surgery.  if the entire tumor is not removed, it has the potential to recur and may require additional surgery or treatments, such as radiation therapy or chemotherapy.  unfortunately, because gangliogliomas are quite rare, there is limited information to show that radiation therapy or chemotherapy are effective treatments for this condition. last updated: 7/11/2011

MalaCards: Ganglioglioma, also known as childhood ganglioglioma, is related to gangliocytoma and neurofibromatosis. An important gene associated with Ganglioglioma is S100B (S100 calcium binding protein B), and among its related pathways are Inhibition of TSC complex formation by PKB and Development IGF-RI signaling. The compounds estrogen and glutamate have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and temporal lobe, and related mouse phenotypes are integument and no phenotypic analysis.

Wikipedia:63 Ganglioglioma is a tumour that arises from ganglion cells in the central nervous system. Gangliogliomas... more...

Aliases & Classifications for Ganglioglioma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

ganglioglioma 8 42 10 44 48 60
childhood ganglioglioma 8 60
adult ganglioglioma 8 60
mixed cell tumors containing both neural ganglionic cells and neural glial cell components 42
ganglioglioma, no icd-o subtype 8


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Disease Ontology8 DOID:5078
MeSH34 D018303
SNOMED-CT56 89880005
NCIt39 C3788

Related Diseases for Ganglioglioma

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17GeneCards, 18GeneDecks
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Diseases related to Ganglioglioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 201)
idRelated DiseaseScoreTop Affiliating Genes
1gangliocytoma30.4SYP
2neurofibromatosis30.4TSC2, TSC1, ENO2, S100B
3astrocytoma30.4TSC2, TSC1, GFAP, NTRK1, SYP, NES
4dysembryoplastic neuroepithelial tumor30.3SYP
5temporal lobe epilepsy30.2GFAP, GRIN1, PVALB
6glioblastoma multiforme30.2BCL2L1, TSC1, GFAP, MYCN, NTRK1, NES
7hydrocephalus30.0TSC1, NES
8meningioma30.0TSC1, GFAP, SYP, S100B, CALB2
9tuberous sclerosis30.0TSC2, TSC1, GFAP, SYP, DCX, NES
10gliosarcoma29.8GFAP
11hemangioma29.8ACTC1
12encephalitis29.8GFAP
13giant cell glioblastoma29.8GFAP
14status epilepticus29.8ENO2, DCX
15neurofibroma29.8ACTC1, SYP, APOD, S100B
16oligodendroglioma29.8TSC1, GFAP, SYP, DCX, APOD
17neuroblastoma29.8ENO2, TH, MYCN, NTRK1, SYP
18neuroendocrine tumor29.8ENO2, MYCN, NTRK1, CHGA, SYP
19ganglioneuroblastoma29.8ENO2, TH, MYCN, NTRK1, SYP, S100B
20epilepsy syndrome29.8TSC2, TSC1, GFAP, GRIN1, DCX, NES
21alzheimer's disease29.8CP, TSC2, TSC1, TH, GFAP, NTRK1
22cerebritis10.4
23neuronitis10.4
24anaplastic ganglioglioma10.4
25pleomorphic xanthoastrocytoma10.3
26desmoplastic infantile ganglioglioma10.2
27atypical teratoid rhabdoid tumor10.1
28desmoplastic infantile astrocytoma/ganglioglioma10.1
29cervicitis10.0
30primitive neuroectodermal tumor10.0
31nasal ganglioglioma10.0
32retinitis10.0DCX
33focal epilepsy10.0DCX
34phaeochromocytoma10.0CHGA
35pneumothorax10.0TSC1
36medulloepithelioma10.0SYP
37perivascular epithelioid cell tumor10.0TSC2
38melanotic neuroectodermal tumor10.0SYP
39somatostatinoma10.0CHGA
40fetal alcohol spectrum disorder10.0PVALB
41rhabdoid tumor10.0ACTC1, SYP
42sertoli-leydig cell tumor10.0CALB2
43dermatofibrosarcoma protuberans10.0ACTC1, S100B
44kidney rhabdoid cancer10.0TSC2
45scrapie10.0PVALB
46pancreatic islet cell tumors10.0CHGA, SYP
47hepatitis10.0CP, MYCN
48subependymoma10.0TSC2
49down syndrome10.0SNCA, S100B
50dysautonomia10.0SNCA

Graphical network of the top 20 diseases related to Ganglioglioma:



Diseases related to ganglioglioma

Clinical Features for Ganglioglioma

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Drugs & Therapeutics for Ganglioglioma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Genetic Tests for Ganglioglioma

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Anatomical Context for Ganglioglioma

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32MalaCards
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MalaCards organs/tissues related to Ganglioglioma:

32
Brain, Spinal cord, Temporal lobe, Cerebellum, Pineal, Cortex, Thalamus, Parietal lobe, Occipital lobe, Medulla oblongata

Animal Models for Ganglioglioma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Ganglioglioma:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.9BCL2L1, TSC2, TSC1, TH, S100B
2MP:00030129.6PVALB, SNCA, DCX, SYP, GRIN1, NTRK1
3MP:00028739.6PVALB, CALB2, S100B, SYP, GRIN1, NTRK1
4MP:00053859.5SNCA, CHGA, GRIN1, MYCN, GFAP, TH
5MP:00053899.3SNCA, DCX, CHGA, GRIN1, MYCN, TSC1
6MP:00053789.3GRIN1, CHGA, DCX, NES, SNCA, NTRK1
7MP:00053849.2MYCN, GRIN1, NES, SNCA, PVALB, GFAP
8MP:00107689.1GRIN1, CHGA, DCX, NES, SNCA, APOD
9MP:00053769.1MYCN, GRIN1, CHGA, SNCA, APOD, GFAP
10MP:00053868.9CP, PVALB, CALB2, S100B, APOD, SNCA
11MP:00036318.8SYP, DCX, NES, SNCA, APOD, CALB2

Publications for Ganglioglioma

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50PubMed
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Articles related to Ganglioglioma:

(show top 50)    (show all 372)
idTitleAuthorsYear
1
Atypical teratoid/rhabdoid tumor with ganglioglioma-like differentiation: case report and review of the literature. (24034858)
2014
2
Desmoplastic infantile ganglioglioma with late presentation. A clinical, radiological and histopathological analysis*. (24355183)
2013
3
Brainstem ganglioglioma in an infant: Case report and review of literature. (23772244)
2013
4
Anaplastic ganglioglioma: a very rare intramedullary spinal cord tumor. (22922809)
2012
5
Strong desmin expression in a congenital desmoplastic infantile ganglioglioma mimicking pleomorphic rhadomyosarcoma: a case report including ultrastructural and cytogenetic evaluation and review of the literature. (22899016)
2012
6
Epilepsy due to a temporal ganglioglioma and its subsequent malignant transformation into a primitive neuroectodermal tumor. (22937479)
2012
7
Desmoplastic ganglioglioma: report of a non-infantile case. (21537571)
2011
8
Paediatric ganglioglioma of the conus medullaris. (21665480)
2011
9
Outcome and prognostic features in anaplastic ganglioglioma: analysis of cases from the SEER database. (21626070)
2011
10
Ganglioglioma associated with alterations of NBN gene. A case report. (19813148)
2009
11
A case of melanotic desmoplastic ganglioglioma. (19622111)
2009
12
Ganglioglioma associated with cerebral cortical dysplasia: an unusual case with extensive leptomeningeal involvement. (18338935)
2008
13
Malignant cerebellar ganglioglioma. (18313924)
2008
14
Ganglioglioma with lytic skull lesions: a case report. (17497058)
2007
15
Radiotherapy after subtotally resected or recurrent ganglioglioma. (17045420)
2007
16
Desmoplastic infantile ganglioglioma with calcification. (16961068)
2006
17
Postoperative radiotherapy in cranial ganglioglioma. (16314944)
2006
18
Desmoplastic infantile ganglioglioma. Morphological, immunohistochemical and genetic features. (16623795)
2006
19
Conventional MR imaging with simultaneous measurements of cerebral blood volume and vascular permeability in ganglioglioma. (15172052)
2004
20
Residents' corner. Answer to case of the month #96. Right frontal lobe ganglioglioma. (15131935)
2004
21
Desmoplastic infantile ganglioglioma: a rare tumor with an unusual presentation. (15494934)
2004
22
The reelin pathway components disabled-1 and p35 in gangliogliomas--a mutation and expression analysis. (15175076)
2004
23
Intramedullary spinal cord ganglioglioma presenting with abnormal abdominal wall movement. Case report. (15633994)
2004
24
Bitemporal ganglioglioma: surgical management of an unusual intracranial and extracranial tumor. (12794476)
2003
25
Malignant rhabdoid meningioma arising in the setting of preexisting ganglioglioma: a diagnosis supported by fluorescence in situ hybridization. Case report. (12507148)
2002
26
Postoperative radiotherapy for ganglioglioma; report of three cases and review of the literature. (12494357)
2002
27
Ganglioglioma of the lateral ventricle presenting with blepharospasm - case report and review of the literature. (11386809)
2001
28
Intracranial ganglioglioma. (10769518)
2000
29
Neuroradiology case of the day. Ganglioglioma. (10470934)
1999
30
Prognostic factors in supratentorial ganglioglioma. (10071688)
1999
31
Ganglioglioma of the trigeminal nerve: MRI. (10447568)
1999
32
MR of spinal cord ganglioglioma. (9613504)
1998
33
Ganglioglioma of the pineal region: case report and review of the literature. (9428903)
1998
34
Anaplastic ganglioglioma with dissemination to the spinal cord: a case report. (9537666)
1998
35
Coexistence of ganglioglioma and cortical dysplasia in a patient with intractable epilepsy--case report. (9362135)
1997
36
Intracranial ganglioglioma: CT and MRI findings. (9311197)
1997
37
Intracranial and spinal metastases from a ganglioglioma with unusual cytogenetic abnormalities in a patient with complex partial seizures. (9403205)
1997
38
Telomere associations in desmoplastic infantile ganglioglioma. (8956861)
1996
39
The immunohistochemistry and ultrastructure of ganglioglioma with chromosomal alterations: a case report. (8705269)
1996
40
An adult patient with cerebellar ganglioglioma. (7525889)
1994
41
Ganglioglioma of the mastoid region: a case report. (8455853)
1993
42
Central nervous system gangliogliomas. Part 1: Pathology. (8246054)
1993
43
Anaplastic ganglioglioma of the brain stem demonstrating active neurosecretory features of neoplastic neuronal cells. (1575013)
1992
44
Intracranial ganglioglioma: MR, CT, and clinical findings in 18 patients. (2106228)
1990
45
Temporal lobe ganglioglioma in refractory epilepsy: CT and MR in three cases. (2213118)
1990
46
Melanotic ganglioglioma of the pineal region. (2596271)
1989
47
Ganglioglioma: a correlative clinicopathological and radiological study of ten surgically treated cases with follow-up. (3574619)
1987
48
Unilateral hemispheric ganglioglioma with infantile spasms. (7425564)
1980
49
Ganglioglioma of the medulla oblongata. (451854)
1979
50
Posterior hypothalamic hamartomas and gangliogliomas causing precocious puberty. (13517481)
1958

Genetic Variations for Ganglioglioma

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Expression for genes affiliated with Ganglioglioma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ganglioglioma

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Pathways for genes affiliated with Ganglioglioma

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53Reactome, 12EMD Millipore, 52R&D Systems, 4Cell Signaling Technology
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Compounds for genes affiliated with Ganglioglioma

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44Novoseek, 24HMDB, 49PharmGKB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience
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Compounds related to Ganglioglioma according to GeneCards/GeneDecks:

(show top 50)    (show all 110)
idCompoundScoreTop Affiliating Genes
1estrogen4410.6PVALB, CALB2, GFAP
2glutamate4410.5GRIN1, GFAP, SNCA, NTRK1
3reticulin4410.4ACTC1, S100B, GFAP, SYP
4vanillylmandelic acid44 2411.4MYCN, ENO2, TH, CHGA
5s 1004410.4ENO2, ACTC1, CHGA, SYP, S100B, GFAP
6b 7234410.3CALB2, ACTC1, S100B, CHGA, SYP
7homovanillic acid44 2411.3TH, GFAP, MYCN, ENO2, CHGA
8l-amino acid4410.3S100B, ENO2, TH, SYP, CHGA
9mucicarmine4410.3ACTC1, CALB2, S100B, SYP
10glucose4410.3TSC2, SNCA, GFAP, ACTC1, TSC1
11dexamethasone44 49 28 1113.2GFAP, TH, ENO2, BCL2L1, S100B
12hematoxylin4410.2ACTC1, ENO2, S100B, GFAP, CHGA, SYP
13glycogen44 2411.2TSC2, GFAP, CHGA, TSC1, ACTC1, SNCA
14mptp4410.2SNCA, GRIN1, GFAP, TH, BCL2L1
15kainate44 2811.2SYP, GRIN1, GFAP, TH, DCX, PVALB
16bromodeoxyuridine4410.2GFAP, CHGA, DCX, ENO2, S100B, NES
17creatinine4410.1CP, ACTC1, GFAP, NTRK1, CHGA, SYP
18dbc-amp4410.1SYP, S100B, ENO2, MYCN, GFAP
19nmda44 2811.1TH, BCL2L1, GRIN1, SYP, CP, GFAP
20ganglioside4410.1NES, SYP, NTRK1, GFAP, ENO2
21silver4410.1SYP, SNCA, CHGA, ENO2, CALB2, GFAP
225-hydroxytryptamine4410.1ENO2, SYP, CHGA, GFAP, CALB2, TH
23formaldehyde44 2411.1GFAP, CHGA, ENO2, ACTC1, TH, SYP
24steroid4410.1SYP, ACTC1, CALB2, TSC2
25catecholamine4410.1ENO2, TH, MYCN, NTRK1, CHGA, SYP
26ethanol44 49 11 2413.0GRIN1, SNCA, PVALB, CALB2, SYP, GFAP
27glutamine4410.0SNCA, SYP, CP, ENO2, GRIN1, S100B
28lactate4410.0CHGA, NTRK1, MYCN, TH, ENO2, CP
29norepinephrine44 11 2411.9S100B, ENO2, SNCA, TH, CHGA, GRIN1
30iron44 2410.9ENO2, ACTC1, TH, MYCN, S100B, GFAP
31gaba449.9CHGA, PVALB, S100B, NES, SYP, CALB2
32smcc449.9CHGA, ENO2, SYP
33adenylate449.9ENO2, S100B, CHGA, NTRK1, GFAP, TH
34etoposide44 49 59 1112.9CHGA, SYP, S100B, BCL2L1, MYCN, ENO2
35progesterone44 59 28 11 2413.8CALB2, S100B, APOD, NES, ACTC1, SYP
36choline44 11 2411.8ENO2, PVALB, CALB2, S100B, SNCA, NES
37acetylcholine44 49 28 11 2413.8CALB2, SNCA, NES, SYP, CHGA, NTRK1
38matrigel449.8NTRK1, CHGA, GFAP, NES, BCL2L1, ACTC1
39cysteine449.7BCL2L1, S100B, CP, GFAP, NTRK1, TH
40dopamine44 28 11 2412.7MYCN, NTRK1, GRIN1, CHGA, NES, SNCA
41nitric oxide44 11 2411.7SYP, CHGA, MYCN, NES, SNCA, CALB2
42lipid449.6NTRK1, SYP, NES, CHGA, SNCA, GRIN1
43testosterone44 59 11 2412.5CP, TSC2, ENO2, ACTC1, TH, GFAP
44oxygen44 2410.5NES, BCL2L1, NTRK1, CP, CHGA, GFAP
45retinoic acid44 2410.5S100B, APOD, NES, SYP, GRIN1, MYCN
46serine449.4PVALB, S100B, SNCA, DCX, SYP, CHGA
47vegf449.4MYCN, GFAP, TH, ACTC1, ENO2, TSC2
48calcium44 49 11 2412.3SNCA, PVALB, CALB2, ENO2, CHGA, ACTC1
49tyrosine449.1CHGA, SYP, NES, SNCA, S100B, PVALB
50paraffin449.1SYP, NES, SNCA, APOD, S100B, CALB2

GO Terms for genes affiliated with Ganglioglioma

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16Gene Ontology
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Cellular components related to Ganglioglioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1TSC1-TSC2 complexGO:03359610.4TSC1, TSC2
2terminal boutonGO:04319510.3TH, GRIN1, SNCA
3synaptic vesicleGO:00802110.2TH, GRIN1, SNCA
4growth coneGO:03042610.1TSC2, TSC1, SNCA
5dendriteGO:03042510.1TSC2, TH, NTRK1, GRIN1, APOD
6neuronal cell bodyGO:0430259.8S100B, APOD, NTRK1, TSC2
7cytosolGO:0058299.5SNCA, DCX, GFAP, TH, ACTC1, ENO2
8cytoplasmGO:0057379.2PVALB, CALB2, S100B, SNCA, NES, GFAP

Biological processes related to Ganglioglioma according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1cellular response to manganese ionGO:07128710.5TH, GRIN1
2long-term synaptic potentiationGO:06029110.4S100B, SNCA, GFAP
3regulation of long-term neuronal synaptic plasticityGO:04816910.4GRIN1, SYP, SNCA
4cellular response to nicotineGO:07131610.4TH, NTRK1
5negative regulation of platelet-derived growth factor receptor signaling pathwayGO:01064210.4SNCA, APOD
6cerebral cortex developmentGO:02198710.3GRIN1, TH, TSC1
7negative regulation of cell sizeGO:04579210.3TSC1, TSC2
8response to ethanolGO:04547110.3ACTC1, TH, NTRK1, GRIN1
9response to nutrient levelsGO:03166710.2TH, NTRK1
10dopamine biosynthetic processGO:04241610.2SNCA, TH
11negative regulation of neuron apoptotic processGO:04352410.2BCL2L1, NTRK1, GRIN1, SNCA
12response to drugGO:0424939.9APOD, SNCA, NTRK1, ACTC1
13agingGO:0075689.8NTRK1, SNCA, APOD

Molecular functions related to Ganglioglioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ferrous iron bindingGO:00819810.2TH, SNCA
2tau protein bindingGO:04815610.0SNCA, S100B
3calcium ion bindingGO:0055099.7GRIN1, PVALB, CALB2, S100B, SNCA, SYP

Products for genes affiliated with Ganglioglioma

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Sources for Ganglioglioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet