MCID: GNG004
MIFTS: 49

Ganglioglioma malady

Categories: Rare diseases, Neuronal diseases, Cancer diseases

Aliases & Classifications for Ganglioglioma

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Sources:
11Disease Ontology, 13DISEASES, 38MeSH, 44NCIt, 47NIH Rare Diseases, 49Novoseek, 53Orphanet, 61SNOMED-CT, 67UMLS, 68UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Ganglioglioma:

Name: Ganglioglioma 11 47 53 49 38 13 67
Childhood Ganglioglioma 11 67
Adult Ganglioglioma 11 67
 
Mixed Cell Tumors Containing Both Neural Ganglionic Cells and Neural Glial Cell Components 47
Cns Ganglioglioma 11

Classifications:



External Ids:

Disease Ontology11 DOID:5078
MeSH38 D018303
Orphanet53 ORPHA251949
UMLS via Orphanet68 C0206716

Summaries for Ganglioglioma

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Wikipedia:70 Ganglioglioma is a rare, slow-growing primary central nervous system (CNS) tumor which most frequently... more...

MalaCards based summary: Ganglioglioma, also known as childhood ganglioglioma, is related to pleomorphic xanthoastrocytoma and pilocytic astrocytoma, and has symptoms including seizures, seizures and seizures. An important gene associated with Ganglioglioma is SYP (Synaptophysin), and among its related pathways are Thyroid cancer and p53 Pathway (RnD). Affiliated tissues include temporal lobe, brain and spinal cord, and related mouse phenotypes are normal and liver/biliary system.

Disease Ontology:11 A cell type benign neoplasm that has material basis in glial-type cells.

Related Diseases for Ganglioglioma

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Diseases related to Ganglioglioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 243)
idRelated DiseaseScoreTop Affiliating Genes
1pleomorphic xanthoastrocytoma30.6BRAF, TP53
2pilocytic astrocytoma30.5CHGA, SYP
3papillary glioneuronal tumor30.2GFAP, SYP
4anaplastic oligodendroglioma30.1GFAP, NES
5giant cell glioblastoma29.0GFAP, NES, SYP, TP53
6anaplastic ganglioglioma12.0
7desmoplastic infantile ganglioglioma12.0
8desmoplastic infantile astrocytoma/ganglioglioma11.9
9nasal ganglioglioma11.9
10gangliocytoma11.2
11grubben de cock borghgraef syndrome10.6GFAP, SYP
12bladder flat intraepithelial lesion10.6GFAP, SYP
13cauda equina neoplasm10.6GFAP, SYP
14glomus tumor10.6GFAP, SYP
15choroid disease10.6GFAP, SYP
16vitamin metabolic disorder10.6GFAP, SYP
17empty sella syndrome10.6GFAP, NES
18malignant granular cell esophageal tumor10.6GFAP, SYP
19ovary mixed epithelial carcinoma10.6CHGA, SYP
20esophagus small cell carcinoma10.6CHGA, SYP
21childhood malignant schwannoma10.5CHGA, SYP
22microglandular adenosis of breast10.5CHGA, SYP
23clear cell adenoma10.5CHGA, SYP
24cervical alveolar soft part sarcoma10.5GFAP, NES
25focal facial dermal dysplasia10.5CHGA, SYP
26punctate porokeratosis10.5CHGA, SYP
27osteoblastoma10.5CHGA, SYP
28urethra adenocarcinoma10.5CHGA, SYP
29esophagus adenocarcinoma10.5CHGA, SYP
30froelich syndrome10.5CHGA, SYP
31cutaneous mastocytosis10.5CHGA, SYP
32pancreatic serous cystic neoplasm10.5CHGA, SYP
33parachordoma10.5SYP, TSC2
34congenital structural myopathy10.5CHGA, GFAP
35pneumonia10.5CHGA, SYP
36verruciform xanthoma of skin10.5CHGA, SYP
37ovarian clear cell malignant adenofibroma10.5CHGA, SYP
38acanthoma10.5CHGA, SYP
39rectum signet ring adenocarcinoma10.4CHGA, SYP
40anaplastic oligoastrocytoma10.4S100B, SYP
41cranial nerve iii tumor10.4CHGA, SYP
42lyme disease - neurological complications10.4GFAP, S100B
43tricuspid valve stenosis10.4CHGA, SYP
44hypogonadism cardiomyopathy10.4S100B, SYP
45pineoblastoma10.4BRAF, GFAP, SYP
46chondroblastoma10.4GFAP, S100B
47buschke-ollendorff syndrome10.4TSC1, TSC2
48subacute leukemia10.4GFAP, S100B
49schwannoma of ureter10.4CHGA, SYP
50inflammatory mfh10.4S100B, SYP

Graphical network of the top 20 diseases related to Ganglioglioma:



Diseases related to ganglioglioma

Symptoms for Ganglioglioma

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UMLS symptoms related to Ganglioglioma:


seizures

Drugs & Therapeutics for Ganglioglioma

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Drugs for Ganglioglioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
DabrafenibapprovedPhase 27944462760, 44516822
Synonyms:
BRAF inhibitor GSK2118436
Dabrafenib
 
GSK2118436
GSK2118436a
Tafinlar
dabrafenib
2Protein Kinase InhibitorsPhase 23612
3
Irinotecanapproved, investigationalPhase 1108097682-44-5, 100286-90-660838
Synonyms:
(+)-Irinotecan
(4S)-4,11-DIETHYL-4-HYDROXY-3,14-DIOXO-3,4,12,14-TETRAHYDRO-1H-PYRANO[3',4':6,7]INDOLIZINO[1,2-B]QUINOLIN-9-YL 1,4'-BIPIPERIDINE-1'-CARBOXYLATE
(4S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-4,12-dihydro-1H-pyrano[3,4-f]quinolino[2,3-a]indolizin-9-yl 4-piperidylpiperidinecarboxylate
1u65
97682-44-5
AC-7469
AC1L1U0Z
AC1Q6PGI
BRD-K08547377-003-02-4
BSPBio_002346
Bio-0054
Biotecan
Biotecan (TN)
C16641
C33H38N4O6
CHEBI:105985
CHEMBL481
CID60838
CP0
Campothecin-11
Campto
Camptosar
 
Camptosar, Campto, CPT-11, Irinotecan
Camptothecin-11
D08086
DB00762
FT-0083650
HSDB 7607
IRINOTECAN HYDROCHLORIDE Trihydrate
IRINOTECAN, CPT-11
Irinotecan (INN)
Irinotecan Hcl
Irinotecan Hydrochloride
Irinotecan Hydrochloride Trihydrate
Irinotecan [INN:BAN]
Irinotecan hydrochloride
Irinotecanum
Irinotecanum [INN-Latin]
LS-44589
NCI60_005051
NSC728073
S1198_Selleck
TL8006026
UNII-7673326042
irinotecan
4
Bevacizumabapproved, investigationalPhase 11968216974-75-3
Synonyms:
216974-75-3
Avastin
Avastin (TN)
Bevacizumab
Bevacizumab (genetical recombination)
 
Bevacizumab (genetical recombination) (JAN)
D06409
R-435
anti-VEGF monoclonal antibody
antiVEGF
bevacizumab
5
CamptothecinexperimentalPhase 16997689-03-4
Synonyms:
(+)-camptothecin
(+)-camptothecine
(s)-(+)-camptothecin
 
(s)-camptothecin
20(S)-Camptothecin
21,22-Secocamptothecin-21-oic acid lactone
Camptothecine
D-camptothecin
6topoisomerase I inhibitorsPhase 11328
7Topoisomerase InhibitorsPhase 14945
8Antineoplastic Agents, PhytogenicPhase 15420
9Angiogenesis InhibitorsPhase 14143
10Angiogenesis Modulating AgentsPhase 14072

Interventional clinical trials:

idNameStatusNCT IDPhase
1Antineoplaston Therapy in Treating Children With Brain TumorsCompletedNCT00003458Phase 2
2Proton Radiotherapy for Pediatric Brain Tumors Requiring Partial Brain IrradiationRecruitingNCT01288235Phase 2
3Phase II Pediatric Study With Dabrafenib in HGG PatientsNot yet recruitingNCT02684058Phase 2
4Evaluation of FDOPA-PET/MRI in Pediatric Patients With CNS TumorsCompletedNCT01999270Phase 1

Search NIH Clinical Center for Ganglioglioma


Cochrane evidence based reviews: ganglioglioma

Genetic Tests for Ganglioglioma

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Anatomical Context for Ganglioglioma

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MalaCards organs/tissues related to Ganglioglioma:

35
Temporal lobe, Brain, Spinal cord, Cerebellum, Pineal, Cortex, Thalamus

Animal Models for Ganglioglioma or affiliated genes

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MGI Mouse Phenotypes related to Ganglioglioma:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.9BRAF, GFAP, S100B, SYP, TP53, TSC2
2MP:00053708.6BRAF, SMARCB1, TP53, TSC1, TSC2
3MP:00020068.6BRAF, SMARCB1, TP53, TSC1, TSC2
4MP:00053858.0BRAF, CHGA, GFAP, SMARCB1, TP53, TSC1
5MP:00036317.7BRAF, GFAP, MAP2, SMARCB1, SYP, TP53
6MP:00053787.6BRAF, CHGA, GFAP, MAP2, SMARCB1, TP53
7MP:00053867.3BRAF, GFAP, MAP2, S100B, SMARCB1, SYP
8MP:00053897.1BRAF, CHGA, MAP2, SMARCB1, TP53, TSC1

Publications for Ganglioglioma

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Articles related to Ganglioglioma:

(show top 50)    (show all 443)
idTitleAuthorsYear
1
Successful Retreatment of a Child with a Refractory Brainstem Ganglioglioma with Vemurafenib. (26579623)
2016
2
Desmoplastic infantile ganglioglioma with focal cortical dysplasia: A rare double pathology in an infant with history of seizures. (26991995)
2016
3
Recurrent ganglioglioma in adults treated with BRAF inhibitors. (26680369)
2016
4
Non-infantile variant of desmoplastic ganglioglioma: Conventional and advanced MR imaging characteristics. (26246092)
2015
5
Pediatric brainstem gangliogliomas show BRAF(V600E) mutation in a high percentage of cases. (24238153)
2014
6
Ganglioglioma mimicking the cerebral abscess in advanced age: a case report. (24101283)
2013
7
Hemorrhagic ganglioglioma of the posterior fossa: case report. (24192758)
2013
8
Mutant BRAF V600E protein in ganglioglioma is predominantly expressed by neuronal tumor cells. (23435618)
2013
9
BRAF(V600E) mutation is a negative prognosticator in pediatric ganglioglioma. (23609006)
2013
10
Ganglioglioma with anaplastic transformation. (22990737)
2012
11
Primary malignant ganglioglioma of the dorsolumbar spine (D11-L1). (20817466)
2010
12
A report of a desmoplastic non-infantile ganglioglioma in a 6-year-old boy with review of the literature. (19280238)
2009
13
Desmoplastic infantile ganglioglioma with a malignant course. (18352812)
2008
14
Desmoplastic ganglioglioma with meningiomatous and myofibroblastic components presenting with epilepsy. (17961139)
2008
15
Anaplastic ganglioglioma in a middle-aged woman: a case report with a review of the literature. (17923741)
2007
16
Desmoplastic infantile ganglioglioma/astrocytoma with cerebrospinal metastasis. (17386372)
2007
17
Ganglioglioma in the third ventricle: report on two cases. (17492319)
2007
18
Spinal cord ganglioglioma presenting as acute paraparesis. (15946791)
2006
19
Anaplastic ganglioglioma of the cerebellopontine angle. Case report. (16308520)
2005
20
Cyanotic breath-holding spell: a life-threatening complication after radical resection of a cervicomedullary ganglioglioma. (15942280)
2005
21
Desmoplastic infantile ganglioglioma with high proliferation index: report of a case. (16519002)
2005
22
Conventional MR imaging with simultaneous measurements of cerebral blood volume and vascular permeability in ganglioglioma. (15172052)
2004
23
Residents' corner. Answer to case of the month #96. Right frontal lobe ganglioglioma. (15131935)
2004
24
Abnormal behavior in children with temporal lobe epilepsy and ganglioglioma. (15380137)
2004
25
Desmoplastic infantile astrocytoma and ganglioglioma: a search for genomic characteristics. (12111357)
2002
26
Desmoplastic infantile ganglioglioma: a potentially malignant tumor? (12409729)
2002
27
Congenital ganglioglioma. (12003306)
2002
28
Ganglioglioma of the lateral ventricle presenting with blepharospasm - case report and review of the literature. (11386809)
2001
29
Intraventricular trigonal ganglioglioma arising from the choroid plexus. (11685629)
2001
30
Ganglioglioma in a patient with Turcot syndrome. Case report. (10616098)
2000
31
Coexistence of a ganglioglioma and Rasmussen's encephalitis. (10461077)
1999
32
Malignant glial tumor arising from the site of a previous hamartoma/ganglioglioma: coincidence or malignant transformation? (10352415)
1999
33
Synaptophysin staining for ganglioglioma. (10219424)
1999
34
Intraventricular ganglioglioma: case report. (9689626)
1998
35
MR of spinal cord ganglioglioma. (9613504)
1998
36
Synaptophysin staining in normal brain: importance for diagnosis of ganglioglioma. (9591724)
1998
37
Anaplastic ganglioglioma: case report and review of the literature. (7984264)
1994
38
An immunohistochemical study of peripheral neuroblastoma, ganglioneuroblastoma, anaplastic ganglioglioma, schwannoma and neurofibroma in cattle. (7962722)
1994
39
Chronic neurological dysfunction attributable to a ganglioglioma. (1398525)
1992
40
Hemifacial spasm in an infant due to fourth ventricular ganglioglioma. Case report. (2045898)
1991
41
Intracranial ganglioglioma: MR imaging. (2119137)
1990
42
Brain ganglioglioma with large extension to subarachnoid space. (2401916)
1990
43
Cerebellar ganglioglioma. Case report. (2092096)
1990
44
Ganglioglioma containing osseous tissue and neurofibrillary tangles. (3132128)
1988
45
Ganglioglioma, a malignant tumor? Correlation with flow deoxyribonucleic acid cytometric analysis. (3226518)
1988
46
Ganglioglioma of the spinal cord in a calf. (3576915)
1987
47
Intractable facial pain associated with a ganglioglioma of the cervicomedullary junction: report of a case. (7099412)
1982
48
Cerebellar ganglioglioma. Case report. (479941)
1979
49
Ganglioglioma of the medulla oblongata. (451854)
1979
50
Ganglioglioma of the cerebellum: angiographic findings. (951566)
1976

Variations for Ganglioglioma

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Cosmic variations for Ganglioglioma:

8
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1COSM476BRAFcentral nervous system,temporal lobe,other,gangliogliomac.1799T>Ap.V600E8
2COSM99759IDH2central nervous system,temporal lobe,other,gangliogliomac.492G>Ap.W164*8

Expression for genes affiliated with Ganglioglioma

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Search GEO for disease gene expression data for Ganglioglioma.

Pathways for genes affiliated with Ganglioglioma

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Pathways related to Ganglioglioma according to GeneCards Suite gene sharing:

(show all 13)
idSuper pathwaysScoreTop Affiliating Genes
19.5BRAF, TP53
2
Show member pathways
9.2TP53, TSC1, TSC2
3
Show member pathways
9.2TP53, TSC1, TSC2
49.2TP53, TSC1, TSC2
5
Show member pathways
9.1BRAF, MAP2, TP53
69.1GFAP, MAP2, S100B, SYP
7
Show member pathways
8.8SMARCB1, TSC1, TSC2
88.8MAP2, TP53, TSC1, TSC2
98.7BRAF, TP53, TSC1, TSC2
108.7BRAF, TP53, TSC1, TSC2
11
Show member pathways
8.7BRAF, TP53, TSC1, TSC2
12
Show member pathways
8.7BRAF, TP53, TSC1, TSC2
138.5GFAP, MAP2, NES, S100B, SYP

GO Terms for genes affiliated with Ganglioglioma

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Cellular components related to Ganglioglioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1TSC1-TSC2 complexGO:00335969.6TSC1, TSC2

Biological processes related to Ganglioglioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1regulation of neuronal synaptic plasticityGO:004816810.2S100B, SYP
2negative regulation of insulin receptor signaling pathwayGO:004662710.1TSC1, TSC2
3negative regulation of TOR signalingGO:003200710.0TSC1, TSC2
4cell cycle arrestGO:00070509.4TP53, TSC1, TSC2
5long-term synaptic potentiationGO:00602918.9BRAF, GFAP, S100B
6negative regulation of cell proliferationGO:00082858.4SMARCB1, TP53, TSC1, TSC2

Molecular functions related to Ganglioglioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1small GTPase bindingGO:003126710.3BRAF, TSC2
2protein bindingGO:00055155.5BRAF, CHGA, GFAP, MAP2, NES, S100B

Sources for Ganglioglioma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet