MCID: GNG004
MIFTS: 45

Ganglioglioma malady

Rare diseases, Neuronal diseases, Cancer diseases categories

Aliases & Classifications for Ganglioglioma

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Sources:
10Disease Ontology, 45NIH Rare Diseases, 47Novoseek, 12DISEASES, 51Orphanet, 65UMLS, 36MeSH, 42NCIt, 59SNOMED-CT, 66UMLS via Orphanet
See all sources

Aliases & Descriptions for Ganglioglioma:

Name: Ganglioglioma 10 45 47 12 51 65 36
Childhood Ganglioglioma 10 65
Adult Ganglioglioma 10 65
 
Mixed Cell Tumors Containing Both Neural Ganglionic Cells and Neural Glial Cell Components 45
Cns Ganglioglioma 10


Classifications:



External Ids:

Disease Ontology10 DOID:5078
MeSH36 D018303
NCIt42 C3788
SNOMED-CT59 89880005
Orphanet51 251949
UMLS via Orphanet66 C0206716

Summaries for Ganglioglioma

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NIH Rare Diseases:45 A ganglioglioma is a rare type of brain tumor, accounting for approximately 1% of all brain tumors.  gangliogliomas occur when a single cell in the brain starts to divide into more cells, forming a tumor.  this can occur when the cell randomly acquires changes (mutations) in genes that regulate how a cell divides.  most gangliogliomas grow slowly and are considered benign.  however, up to 10% of gangliogliomas may grow more rapidly and become malignant, meaning the tumor affects the surrounding brain tissue.    the main treatment for ganglioglioma is removal of the entire tumor during surgery.  if the entire tumor is not removed, it has the potential to recur and may require additional surgery or treatments, such as radiation therapy or chemotherapy.  unfortunately, because gangliogliomas are quite rare, there is limited information to show that radiation therapy or chemotherapy are effective treatments for this condition. last updated: 7/11/2011

MalaCards based summary: Ganglioglioma, also known as childhood ganglioglioma, is related to anaplastic ganglioglioma and headache. An important gene associated with Ganglioglioma is SYP (Synaptophysin), and among its related pathways are FSH signaling pathway and Thyroid cancer. Affiliated tissues include brain, temporal lobe and spinal cord, and related mouse phenotypes are renal/urinary system and normal.

Disease Ontology:10 A cell type benign neoplasm that has material basis in glial-type cells.

Wikipedia:68 Ganglioglioma is a rare, slow-growing primary central nervous system (CNS) tumor which most frequently... more...

Related Diseases for Ganglioglioma

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Diseases related to Ganglioglioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 256)
idRelated DiseaseScoreTop Affiliating Genes
1anaplastic ganglioglioma31.2GFAP, S100B, SYP
2headache30.4GFAP, S100B
3oligodendroglioma30.2CHGA, GFAP, SYP
4gliosarcoma29.9GFAP, SYP, TP53
5desmoplastic infantile ganglioglioma10.8
6cerebritis10.5
7neuronitis10.5
8pleomorphic xanthoastrocytoma10.4
9neurofibromatosis10.4
10astrocytoma10.4
11glioblastoma10.4
12gangliocytoma10.3
13dysembryoplastic neuroepithelial tumor10.3
14cutaneous paget's disease10.3GFAP, SYP
15desmoplastic small round cell tumor10.3GFAP, SYP
16pineal parenchymal tumor of intermediate differenciation10.3GFAP, SYP
17lung hilum cancer10.3GFAP, SYP
18hantavirus pulmonary syndrome10.3GFAP, SYP
19supine hypotensive syndrome10.3GFAP, SYP
20pineal region teratoma10.3GFAP, SYP
21vulvar inverted follicular keratosis10.3GFAP, SYP
22landau-kleffner syndrome10.3GFAP, SMARCB1
23rhabdomyosarcoma10.3GFAP, SMARCB1
24fatal infantile encephalocardiomyopathy10.3GFAP, SYP
25neurofibromatosis, type 110.3
26rhabdoid tumor10.3
27nasal ganglioglioma10.3
28desmoplastic infantile astrocytoma/ganglioglioma10.3
29anaplastic oligoastrocytoma10.3GFAP, NES
30paranoid schizophrenia10.3GFAP, SMARCB1
31endometrial stromal sarcoma10.3CHGA, SYP
32flat retinoschisis10.3CHGA, SYP
33cerebellum cancer10.3GFAP, SYP
34third-degree atrioventricular block10.3CHGA, SYP
35auditory system disease10.3CHGA, SYP
36small cell lung cancer, childhood10.3CHGA, SYP
37hemangiopericytoma10.3CHGA, SYP
38rift valley fever10.3SYP, TSC2
39peritoneum cancer10.3CHGA, SYP
40pituitary adenoma10.2GFAP, SYP
41central nervous system germinoma10.2GFAP, NES
42conjunctiva squamous cell carcinoma10.2CHGA, SYP
43pancreatic serous cystic neoplasm10.2CHGA, SYP
44mesenchymoma10.2SMARCB1, SYP
45cavernous hemangioma10.2CHGA, SYP
46non-langerhans-cell histiocytosis10.2CHGA, SYP
47multilocular cystic renal cell carcinoma10.2CHGA, SYP
48congenital adrenal hyperplasia10.2MAP2, SYP
49seminal vesicle tumor10.2MAP2, SYP
50vulvar sebaceous carcinoma10.2CHGA, SYP

Graphical network of the top 20 diseases related to Ganglioglioma:



Diseases related to ganglioglioma

Symptoms for Ganglioglioma

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Drugs & Therapeutics for Ganglioglioma

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Drugs for Ganglioglioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Irinotecanapproved, investigationalPhase 0101397682-44-5, 100286-90-660838
Synonyms:
(+)-Irinotecan
(4S)-4,11-DIETHYL-4-HYDROXY-3,14-DIOXO-3,4,12,14-TETRAHYDRO-1H-PYRANO[3',4':6,7]INDOLIZINO[1,2-B]QUINOLIN-9-YL 1,4'-BIPIPERIDINE-1'-CARBOXYLATE
(4S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-4,12-dihydro-1H-pyrano[3,4-f]quinolino[2,3-a]indolizin-9-yl 4-piperidylpiperidinecarboxylate
1u65
97682-44-5
AC-7469
AC1L1U0Z
AC1Q6PGI
BRD-K08547377-003-02-4
BSPBio_002346
Bio-0054
Biotecan
Biotecan (TN)
C16641
C33H38N4O6
CHEBI:105985
CHEMBL481
CID60838
CP0
Campothecin-11
Campto
Camptosar
 
Camptosar, Campto, CPT-11, Irinotecan
Camptothecin-11
D08086
DB00762
FT-0083650
HSDB 7607
IRINOTECAN HYDROCHLORIDE Trihydrate
IRINOTECAN, CPT-11
Irinotecan
Irinotecan (INN)
Irinotecan Hcl
Irinotecan Hydrochloride
Irinotecan Hydrochloride Trihydrate
Irinotecan [INN:BAN]
Irinotecan hydrochloride
Irinotecanum
Irinotecanum [INN-Latin]
LS-44589
NCI60_005051
NSC728073
S1198_Selleck
TL8006026
UNII-7673326042
irinotecan
2
Bevacizumabapproved, investigationalPhase 01820216974-75-3
Synonyms:
216974-75-3
Avastin
Avastin (TN)
Bevacizumab
Bevacizumab (genetical recombination)
 
Bevacizumab (genetical recombination) (JAN)
D06409
R-435
anti-VEGF monoclonal antibody
antiVEGF
bevacizumab

Interventional clinical trials:

idNameStatusNCT IDPhase
1Proton Radiotherapy for Pediatric Brain Tumors Requiring Partial Brain IrradiationRecruitingNCT01288235Phase 2
2Phase II Pediatric Study With Dabrafenib in HGG PatientsNot yet recruitingNCT02684058Phase 2
3Evaluation of FDOPA-PET/MRI in Pediatric Patients With CNS TumorsRecruitingNCT01999270Phase 0

Search NIH Clinical Center for Ganglioglioma


Cochrane evidence based reviews: Ganglioglioma

Genetic Tests for Ganglioglioma

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Anatomical Context for Ganglioglioma

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MalaCards organs/tissues related to Ganglioglioma:

33
Brain, Temporal lobe, Spinal cord, Cerebellum, Pineal, Cortex, Thalamus

Animal Models for Ganglioglioma or affiliated genes

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MGI Mouse Phenotypes related to Ganglioglioma:

38 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.3BRAF, CHGA, TP53, TSC1, TSC2
2MP:00028738.3BRAF, GFAP, S100B, SYP, TP53, TSC2
3MP:00053708.2BRAF, SMARCB1, TP53, TSC1, TSC2
4MP:00020067.9BRAF, SMARCB1, TP53, TSC1, TSC2
5MP:00053797.6BRAF, CHGA, MAP2, TP53, TSC1, TSC2
6MP:00053807.5BRAF, NES, SMARCB1, TP53, TSC1, TSC2
7MP:00053857.4BRAF, CHGA, GFAP, SMARCB1, TP53, TSC1
8MP:00053847.2BRAF, GFAP, NES, SMARCB1, TP53, TSC1
9MP:00053896.8BRAF, CHGA, MAP2, SMARCB1, TP53, TSC1
10MP:00053866.6BRAF, GFAP, MAP2, NES, S100B, TP53
11MP:00107686.4BRAF, CHGA, GFAP, MAP2, NES, SMARCB1
12MP:00053786.4BRAF, CHGA, GFAP, MAP2, NES, SMARCB1
13MP:00036316.2BRAF, GFAP, MAP2, NES, SMARCB1, SYP

Publications for Ganglioglioma

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Articles related to Ganglioglioma:

(show top 50)    (show all 399)
idTitleAuthorsYear
1
An Unusual Case of Constitutional Mismatch Repair Deficiency Syndrome With Anaplastic Ganglioglioma, Colonic Adenocarcinoma, Osteosarcoma, Acute Myeloid Leukemia, and Signs of Neurofibromatosis Type 1: Case Report. (25850602)
2015
2
Anaplastic ganglioglioma: a report of three cases and review of the literature. (25862009)
2015
3
Non-infantile variant of desmoplastic ganglioglioma: Conventional and advanced MR imaging characteristics. (26246092)
2015
4
Response of recurrent BRAFV600E mutated ganglioglioma to Vemurafenib as single agent. (25524464)
2014
5
Ganglioglioma mimicking the cerebral abscess in advanced age: a case report. (24101283)
2013
6
Hemorrhagic ganglioglioma of the posterior fossa: case report. (24192758)
2013
7
Ganglioglioma with anaplastic transformation. (22990737)
2012
8
Anaplastic ganglioglioma: a very rare intramedullary spinal cord tumor. (22922809)
2012
9
Composite ganglioglioma/dysembryoplastic neuroepithelial tumor: a clinicopathologic study of 8 cases. (22221701)
2012
10
Strong desmin expression in a congenital desmoplastic infantile ganglioglioma mimicking pleomorphic rhadomyosarcoma: a case report including ultrastructural and cytogenetic evaluation and review of the literature. (22899016)
2012
11
Intraventricular ganglioglioma with bleed: a rare case report. (20644285)
2010
12
Primary malignant ganglioglioma of the dorsolumbar spine (D11-L1). (20817466)
2010
13
Ganglioglioma in the cerebellopontine angle of an adult without seizures. (19772036)
2009
14
Minimum apparent diffusion coefficient for the differential diagnosis of ganglioglioma. (19138470)
2009
15
Desmoplastic infantile ganglioglioma with a malignant course. (18352812)
2008
16
Anaplastic ganglioglioma in a middle-aged woman: a case report with a review of the literature. (17923741)
2007
17
Desmoplastic infantile ganglioglioma/astrocytoma with cerebrospinal metastasis. (17386372)
2007
18
Malignant and benign ganglioglioma: a pathological and molecular study. (17259542)
2007
19
Spinal cord ganglioglioma presenting as acute paraparesis. (15946791)
2006
20
Anaplastic ganglioglioma of the cerebellopontine angle. Case report. (16308520)
2005
21
Desmoplastic non-infantile ganglioglioma. (15875908)
2005
22
Cyanotic breath-holding spell: a life-threatening complication after radical resection of a cervicomedullary ganglioglioma. (15942280)
2005
23
Conventional MR imaging with simultaneous measurements of cerebral blood volume and vascular permeability in ganglioglioma. (15172052)
2004
24
Residents' corner. Answer to case of the month #96. Right frontal lobe ganglioglioma. (15131935)
2004
25
Desmoplastic infantile astrocytoma and ganglioglioma: a search for genomic characteristics. (12111357)
2002
26
Desmoplastic infantile ganglioglioma: a potentially malignant tumor? (12409729)
2002
27
Congenital ganglioglioma. (12003306)
2002
28
Ganglioglioma of the lateral ventricle presenting with blepharospasm - case report and review of the literature. (11386809)
2001
29
Intraventricular trigonal ganglioglioma arising from the choroid plexus. (11685629)
2001
30
Malignant transformation of a gangliocytoma/ganglioglioma into a glioblastoma multiforme: a molecular genetic analysis. Case report. (11453385)
2001
31
Intracranial ganglioglioma. (10769518)
2000
32
Tuberin expression in ganglioglioma. (10808554)
2000
33
Coexistence of a ganglioglioma and Rasmussen's encephalitis. (10461077)
1999
34
Intraventricular ganglioglioma: case report. (9689626)
1998
35
Telomere associations in desmoplastic infantile ganglioglioma. (8956861)
1996
36
Image interpretation session. Ganglioglioma. (7899606)
1995
37
Anaplastic ganglioglioma: case report and review of the literature. (7984264)
1994
38
Ganglioglioma of the mastoid region: a case report. (8455853)
1993
39
Chronic neurological dysfunction attributable to a ganglioglioma. (1398525)
1992
40
Cerebral ganglioglioma with long history and unusual prominence of the mesenchymal elements. Case report. (1297930)
1992
41
Hemifacial spasm in an infant due to fourth ventricular ganglioglioma. Case report. (2045898)
1991
42
Cerebral ganglioglioma and neurofibromatosis type I. Case report and review of the literature. (1922756)
1991
43
Intracranial ganglioglioma: MR imaging. (2119137)
1990
44
Ganglioglioma containing osseous tissue and neurofibrillary tangles. (3132128)
1988
45
Ganglioglioma of the spinal cord in a calf. (3576915)
1987
46
The occurrence of catecholamine neurons in a parietal lobe ganglioglioma. (2887276)
1987
47
Unilateral hemispheric ganglioglioma with infantile spasms. (7425564)
1980
48
Cerebellar ganglioglioma. Case report. (479941)
1979
49
Ganglioglioma of the cerebellum: angiographic findings. (951566)
1976
50
Intraocular ganglioglioma in a dog. (5393729)
1969

Variations for Ganglioglioma

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Expression for genes affiliated with Ganglioglioma

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Search GEO for disease gene expression data for Ganglioglioma.

Pathways for genes affiliated with Ganglioglioma

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GO Terms for genes affiliated with Ganglioglioma

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Cellular components related to Ganglioglioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1TSC1-TSC2 complexGO:003359610.1TSC1, TSC2
2cell bodyGO:00442979.3BRAF, GFAP, MAP2
3protein complexGO:00432348.6MAP2, SMARCB1, TP53, TSC1

Biological processes related to Ganglioglioma according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1glucose importGO:004632310.1TSC1, TSC2
2negative regulation of insulin receptor signaling pathwayGO:004662710.1TSC1, TSC2
3negative regulation of TOR signalingGO:003200710.1TSC1, TSC2
4regulation of neuronal synaptic plasticityGO:004816810.0S100B, SYP
5cell cycle arrestGO:00070509.4TP53, TSC1, TSC2
6long-term synaptic potentiationGO:00602919.2BRAF, GFAP, S100B
7central nervous system developmentGO:00074179.0NES, S100B, TP53
8regulation of cell cycleGO:00517268.9TP53, TSC1, TSC2
9negative regulation of cell proliferationGO:00082858.7SMARCB1, TP53, TSC1, TSC2

Molecular functions related to Ganglioglioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1small GTPase bindingGO:00312679.3BRAF, TSC2

Sources for Ganglioglioma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet