MCID: GNG004
MIFTS: 43

Ganglioglioma malady

Categories: Rare diseases, Neuronal diseases, Cancer diseases

Aliases & Classifications for Ganglioglioma

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Sources:
10Disease Ontology, 45NIH Rare Diseases, 47Novoseek, 12DISEASES, 51Orphanet, 36MeSH, 65UMLS, 42NCIt, 59SNOMED-CT, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Ganglioglioma:

Name: Ganglioglioma 10 45 47 12 51 36 65
Childhood Ganglioglioma 10 65
Adult Ganglioglioma 10 65
 
Mixed Cell Tumors Containing Both Neural Ganglionic Cells and Neural Glial Cell Components 45
Cns Ganglioglioma 10

Classifications:



External Ids:

Disease Ontology10 DOID:5078
MeSH36 D018303
SNOMED-CT59 89880005
Orphanet51 251949
UMLS via Orphanet66 C0206716
UMLS65 C0206716, C1332202, C1332969

Summaries for Ganglioglioma

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NIH Rare Diseases:45 A ganglioglioma is a rare type of brain tumor, accounting for approximately 1% of all brain tumors.  gangliogliomas occur when a single cell in the brain starts to divide into more cells, forming a tumor.  this can occur when the cell randomly acquires changes (mutations) in genes that regulate how a cell divides.  most gangliogliomas grow slowly and are considered benign.  however, up to 10% of gangliogliomas may grow more rapidly and become malignant, meaning the tumor affects the surrounding brain tissue.    the main treatment for ganglioglioma is removal of the entire tumor during surgery.  if the entire tumor is not removed, it has the potential to recur and may require additional surgery or treatments, such as radiation therapy or chemotherapy.  unfortunately, because gangliogliomas are quite rare, there is limited information to show that radiation therapy or chemotherapy are effective treatments for this condition. last updated: 7/11/2011

MalaCards based summary: Ganglioglioma, also known as childhood ganglioglioma, is related to myeloma and substance abuse. An important gene associated with Ganglioglioma is SYP (Synaptophysin), and among its related pathways are Thyroid cancer and FSH signaling pathway. Affiliated tissues include brain, temporal lobe and bone, and related mouse phenotypes are liver/biliary system and tumorigenesis.

Disease Ontology:10 A cell type benign neoplasm that has material basis in glial-type cells.

Wikipedia:68 Ganglioglioma is a rare, slow-growing primary central nervous system (CNS) tumor which most frequently... more...

Related Diseases for Ganglioglioma

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Diseases related to Ganglioglioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 425)
idRelated DiseaseScoreTop Affiliating Genes
1myeloma30.4SYP, TP53
2substance abuse30.1GFAP, TP53
3anterior spinal artery syndrome29.9GFAP, TP53
4anaplastic ganglioglioma12.5
5desmoplastic infantile ganglioglioma12.3
6nasal ganglioglioma12.3
7desmoplastic infantile astrocytoma/ganglioglioma12.3
8malignant pineal area germ cell neoplasm10.5BRAF, SYP
9pilocytic astrocytoma10.5BRAF, TP53
10splenogonadal fusion limb defects micrognatia10.4BRAF, TP53
11herpes simplex10.4BRAF, TP53
12brain glioma10.4SYP, TP53
13chronic rhinitis10.4SYP, TP53
14fallopian tube serous papilloma10.4SYP, TP53
15fallopian tube teratoma10.4SYP, TP53
16rectum kaposi's sarcoma10.4SMARCB1, SYP
17pleomorphic carcinoma10.4SYP, TP53
18anal gland neoplasm10.4SMARCB1, SYP
19cardiovascular organ benign neoplasm10.4SYP, TP53
20vulval paget's disease10.4SMARCB1, TP53
21gangliocytoma10.4
22urinary bladder villous adenoma10.4GFAP, SYP
23adult malignant schwannoma10.3GFAP, SYP
24skin glomus tumor10.3GFAP, SYP
25anovulation10.3GFAP, SYP
26hypothalamic neoplasm10.3MAP2, SYP
27mixed glioma10.3GFAP, SYP
28familial primary hypomagnesemia with hypercalciuria and nephrocalcinosis with severe ocular involvement10.3GFAP, SYP
29mixed ductal-endocrine carcinoma10.3MAP2, SYP
30kidney rhabdoid cancer10.3SMARCB1, SYP
31bilateral hyperactive labyrinth10.3GFAP, SYP
32alveoli adenoma10.3GFAP, TP53
33pineal gland astrocytoma10.3GFAP, TP53
34ovarian mucinous cystadenofibroma10.3GFAP, TP53
35ependymoblastoma10.3GFAP, SYP
36myoblastoma10.3GFAP, SYP
37congenital disorder of glycosylation, type if10.3GFAP, TP53
38merrf syndrome10.3SMARCB1, TP53
39sympathetic neurilemmoma10.3GFAP, SYP
40lateral ventricle meningioma10.3GFAP, TP53
41behcet's syndrome arthropathy10.3GFAP, SYP
42childhood medulloblastoma10.3GFAP, SMARCB1
43birdshot chorioretinopathy10.3GFAP, SYP
44subependymal giant cell astrocytoma10.3GFAP, TP53
45eye disease10.3GFAP, TP53
46lung cancer10.3
47spinal cord oligodendroglioma10.3GFAP, SYP
48atypical polypoid adenomyoma10.3MAP2, SYP
49thrombophlebitis10.3GFAP, SMARCB1
50myxopapillary ependymoma10.3GFAP, TP53

Graphical network of the top 20 diseases related to Ganglioglioma:



Diseases related to ganglioglioma

Symptoms for Ganglioglioma

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Drugs & Therapeutics for Ganglioglioma

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Drugs for Ganglioglioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
DabrafenibapprovedPhase 27044462760, 44516822
Synonyms:
BRAF inhibitor GSK2118436
Dabrafenib
Dabrafenib Mesylate
 
GSK2118436
GSK2118436a
Tafinlar
dabrafenib
2Protein Kinase InhibitorsPhase 23162
3
Bevacizumabapproved, investigationalPhase 01875216974-75-3
Synonyms:
216974-75-3
Avastin
Avastin (TN)
Bevacizumab
Bevacizumab (genetical recombination)
 
Bevacizumab (genetical recombination) (JAN)
D06409
R-435
anti-VEGF monoclonal antibody
antiVEGF
bevacizumab
4
Irinotecanapproved, investigationalPhase 0104497682-44-5, 100286-90-660838
Synonyms:
(+)-Irinotecan
(4S)-4,11-DIETHYL-4-HYDROXY-3,14-DIOXO-3,4,12,14-TETRAHYDRO-1H-PYRANO[3',4':6,7]INDOLIZINO[1,2-B]QUINOLIN-9-YL 1,4'-BIPIPERIDINE-1'-CARBOXYLATE
(4S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-4,12-dihydro-1H-pyrano[3,4-f]quinolino[2,3-a]indolizin-9-yl 4-piperidylpiperidinecarboxylate
1u65
97682-44-5
AC-7469
AC1L1U0Z
AC1Q6PGI
BRD-K08547377-003-02-4
BSPBio_002346
Bio-0054
Biotecan
Biotecan (TN)
C16641
C33H38N4O6
CHEBI:105985
CHEMBL481
CID60838
CP0
Campothecin-11
Campto
Camptosar
 
Camptosar, Campto, CPT-11, Irinotecan
Camptothecin-11
D08086
DB00762
FT-0083650
HSDB 7607
IRINOTECAN HYDROCHLORIDE Trihydrate
IRINOTECAN, CPT-11
Irinotecan
Irinotecan (INN)
Irinotecan Hcl
Irinotecan Hydrochloride
Irinotecan Hydrochloride Trihydrate
Irinotecan [INN:BAN]
Irinotecan hydrochloride
Irinotecanum
Irinotecanum [INN-Latin]
LS-44589
NCI60_005051
NSC728073
S1198_Selleck
TL8006026
UNII-7673326042
irinotecan
5Topoisomerase InhibitorsPhase 04081
6topoisomerase I inhibitorsPhase 01131
7Antineoplastic Agents, PhytogenicPhase 04294
8Angiogenesis InhibitorsPhase 03688
9Angiogenesis Modulating AgentsPhase 03611

Interventional clinical trials:

idNameStatusNCT IDPhase
1Proton Radiotherapy for Pediatric Brain Tumors Requiring Partial Brain IrradiationRecruitingNCT01288235Phase 2
2Phase II Pediatric Study With Dabrafenib in HGG PatientsNot yet recruitingNCT02684058Phase 2
3Evaluation of FDOPA-PET/MRI in Pediatric Patients With CNS TumorsRecruitingNCT01999270Phase 0

Search NIH Clinical Center for Ganglioglioma


Cochrane evidence based reviews: ganglioglioma

Genetic Tests for Ganglioglioma

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Anatomical Context for Ganglioglioma

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MalaCards organs/tissues related to Ganglioglioma:

33
Brain, Temporal lobe, Bone, Breast, Endothelial, Prostate, Liver

Animal Models for Ganglioglioma or affiliated genes

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MGI Mouse Phenotypes related to Ganglioglioma:

38 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.8BRAF, SMARCB1, TP53, TSC1, TSC2
2MP:00020068.7BRAF, SMARCB1, TP53, TSC1, TSC2
3MP:00053808.2BRAF, NSD1, SMARCB1, TP53, TSC1, TSC2
4MP:00053678.1BRAF, CHGA, TP53, TSC1, TSC2
5MP:00053867.9BRAF, GFAP, MAP2, SYP, TP53, TSC1
6MP:00053797.8BRAF, CHGA, MAP2, TP53, TSC1, TSC2
7MP:00036317.4BRAF, GFAP, MAP2, SMARCB1, SYP, TP53
8MP:00053897.3BRAF, CHGA, MAP2, SMARCB1, TP53, TSC1
9MP:00053857.2BRAF, CHGA, GFAP, SMARCB1, TP53, TSC1
10MP:00053786.4BRAF, CHGA, GFAP, MAP2, SMARCB1, TP53
11MP:00107686.0BRAF, CHGA, GFAP, MAP2, NSD1, SMARCB1

Publications for Ganglioglioma

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Articles related to Ganglioglioma:

(show top 50)    (show all 408)
idTitleAuthorsYear
1
Histopathological diagnosis of epithelial crateriform tumors: Keratoacanthoma and other epithelial crateriform tumors. (27076258)
2016
2
Expression of macrophage migration inhibitory factor and CD74 in the inner ear and middle ear in lipopolysaccharide-induced otitis media. (27181906)
2016
3
Efficacy and safety of domestic leuprorelin in girls with idiopathic central precocious puberty: a multicenter, randomized, parallel, controlled trial. (25963350)
2015
4
Crystallization and preliminary X-ray crystallographic analysis of the complex between the N-D1 domain of VCP from Homo sapiens and the N domain of OTU1 from Saccharomyces cerevisiae. (25084388)
2014
5
Intragenic integration in DLC1 sustains factor VIII expression in primary human cells without insertional oncogenicity. (24553346)
2014
6
Median neuropathy at the wrist as an early manifestation of diabetic neuropathy. (25422772)
2014
7
Malignant peripheral nerve sheath tumor as a cause of chronic cardiac insufficiency in cattle. (23369465)
2013
8
Hdac6 regulates Tip60-p400 function in stem cells. (24302573)
2013
9
Leiomyoma of the vulva. (23404606)
2013
10
HLA-B*13:01 and the dapsone hypersensitivity syndrome. (24152261)
2013
11
Human cytosolic sialidase NEU2-low general tissue expression but involvement in PC-3 prostate cancer cell survival. (23068092)
2012
12
Computer-assisted image analysis of temporal retinal vessel width and tortuosity in retinopathy of prematurity for the assessment of disease severity and treatment outcome. (21907122)
2011
13
Mediastinal mature cystic teratoma perforating into the lung. (20876619)
2010
14
Hepatic angiomyolipoma and intramural small intestinal schwannoma: a coincidence or a relationship? (19282295)
2010
15
HIPK2 and cancer cell resistance to therapy. (19086839)
2008
16
WSU-WM and BCWM.1 should not be assumed to represent WaldenstrAPm macroglobulinemia cell lines. (18650470)
2008
17
CD14 genetics in sarcoidosis patients; who's in control? (18496988)
2007
18
Longitudinal mitral annular early diastolic velocities in differentiating effusive constrictive pericarditis from restrictive cardiomyopathy: a case with extreme and straddling variations in regional velocities. (19122257)
2007
19
Activation of extracellular signal-regulated kinase 5 reduces cardiac apoptosis and dysfunction via inhibition of a phosphodiesterase 3A/inducible cAMP early repressor feedback loop. (17272811)
2007
20
Intraoperative monitoring of hearing during cerebellopontine angle tumor surgery using transtympanic electrocochleography. (17529854)
2007
21
Toll-like receptor in salivary glands from patients with SjAPgren's syndrome: functional analysis by human salivary gland cell line. (17407216)
2007
22
NK026680, a novel compound suppressive of dendritic cell function, ameliorates mortality in acute lethal graft-versus-host reaction in mice. (16299543)
2006
23
Iron restriction negatively affects bone in female rats and mineralization of hFOB osteoblast cells. (16565433)
2006
24
Azoospermia: virtual reality or possible to quantify? (16598028)
2006
25
Association of footwear with patellofemoral pain syndrome in runners. (16526832)
2006
26
Theoretical proposal: allele dosage of MAP2K4/MKK4 could rationalize frequent 17p loss in diverse human cancers. (16721048)
2006
27
Congenital hemihypertrophy with hemihypertrichosis. (16043924)
2005
28
Epidermolysis bullosa acquisita in childhood. (12692360)
2003
29
Biogenesis and nuclear export of ribosomal subunits in higher eukaryotes depend on the CRM1 export pathway. (12724356)
2003
30
Does water-perfused catheter overdiagnose anismus compared to balloon probe? (12523590)
2002
31
The novel helicase homologue DDX32 is down-regulated in acute lymphoblastic leukemia. (12163057)
2002
32
Soft-tissue chondroma in the thumb. (12409791)
2002
33
Detection of B lymphoma cells undergoing apoptosis by Annexin-V assay. (12894879)
2002
34
Gene therapy for hypertension: sense and antisense strategies. (11727501)
2001
35
Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome. (10934466)
2000
36
A cutaneous case of giant cell angiofibroma occurring with dermatofibrosarcoma protuberans and showing bimodal CD34+ fibroblastic and FXIIIa+ histiocytic immunophenotype. (9696292)
1998
37
Neuroendocrine tumor imaging: can 18F-fluorodeoxyglucose positron emission tomography detect tumors with poor prognosis and aggressive behavior? (9597933)
1998
38
The aetiology of Raynaud's phenomenon. (9794259)
1998
39
Recombinant human TSH receptor expressed in E. coli. (9247724)
1997
40
Oxymetric and spectrophotometric study of the ascorbate oxidase activity shown by frog epidermis tyrosinase. (8811840)
1996
41
Evaluation and comparison of two new prostate carcinoma markers. Free-prostate specific antigen and prostate specific membrane antigen. (8756376)
1996
42
Total splenic infarction in acute pancreatitis. (8930045)
1996
43
Effect of low-dose heparin on urinary albumin excretion in insulin-dependent diabetes mellitus. (7853952)
1995
44
Receptor mediation of the stimulus properties of cholecystokinin. (8029299)
1994
45
Effects of type I-interferons on human thyroid epithelial cells derived from normal and tumour tissue. (7824050)
1994
46
Structure and expression of fibulin-2, a novel extracellular matrix protein with multiple EGF-like repeats and consensus motifs for calcium binding. (8245130)
1993
47
Treatment of keloids and hypertrophic scars with an argon laser. (3959718)
1986
48
Progeria: report of a case with post-mortem findings. (13165959)
1954
49
Mumps meningoencephalitis with and without parotitis. (18147966)
1949
50

Variations for Ganglioglioma

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Cosmic variations for Ganglioglioma:

7 (show top 50)    (show all 267)
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
1COSM28746IDH1central nervous system,brain,other,neoplasm3
2COSM28746IDH1central nervous system,brain,other,neoplasm3
3COSM28746IDH1central nervous system,brain,other,neoplasm3
4COSM28746IDH1central nervous system,brain,other,neoplasm3
5COSM28746IDH1central nervous system,brain,other,ganglioglioma3
6COSM28746IDH1central nervous system,brain,other,neoplasm3
7COSM28746IDH1central nervous system,brain,other,neoplasm3
8COSM28746IDH1central nervous system,brain,other,neoplasm3
9COSM28746IDH1central nervous system,brain,other,neoplasm3
10COSM28746IDH1central nervous system,brain,other,neoplasm3
11COSM28746IDH1central nervous system,brain,other,neoplasm3
12COSM28746IDH1central nervous system,brain,other,neoplasm3
13COSM28746IDH1central nervous system,brain,other,neoplasm3
14COSM28746IDH1central nervous system,brain,other,neoplasm3
15COSM28746IDH1central nervous system,brain,other,neoplasm3
16COSM28746IDH1central nervous system,brain,other,neoplasm3
17COSM28746IDH1central nervous system,brain,other,neoplasm3
18COSM28746IDH1central nervous system,brain,other,neoplasm3
19COSM28746IDH1central nervous system,brain,other,neoplasm3
20COSM28746IDH1central nervous system,brain,other,neoplasm3
21COSM28746IDH1central nervous system,brain,other,neoplasm3
22COSM28746IDH1central nervous system,brain,other,neoplasm3
23COSM28746IDH1central nervous system,brain,other,neoplasm3
24COSM28746IDH1central nervous system,brain,other,neoplasm3
25COSM28746IDH1central nervous system,brain,other,neoplasm3
26COSM28746IDH1central nervous system,brain,other,neoplasm3
27COSM28746IDH1central nervous system,brain,other,neoplasm3
28COSM28746IDH1central nervous system,brain,other,neoplasm3
29COSM28746IDH1central nervous system,brain,other,neoplasm3
30COSM28746IDH1central nervous system,brain,other,neoplasm3
31COSM28746IDH1central nervous system,brain,other,neoplasm3
32COSM28746IDH1central nervous system,brain,other,neoplasm3
33COSM28746IDH1central nervous system,brain,other,neoplasm3
34COSM28746IDH1central nervous system,brain,other,neoplasm3
35COSM28746IDH1central nervous system,brain,other,neoplasm3
36COSM28746IDH1central nervous system,brain,other,neoplasm3
37COSM28746IDH1central nervous system,brain,other,neoplasm3
38COSM28746IDH1central nervous system,brain,other,neoplasm3
39COSM28746IDH1central nervous system,brain,other,neoplasm3
40COSM28746IDH1central nervous system,brain,other,neoplasm3
41COSM28746IDH1central nervous system,brain,other,neoplasm3
42COSM28746IDH1central nervous system,brain,other,neoplasm3
43COSM28746IDH1central nervous system,brain,other,neoplasm3
44COSM28746IDH1central nervous system,brain,other,neoplasm3
45COSM28746IDH1central nervous system,brain,other,neoplasm3
46COSM28746IDH1central nervous system,brain,other,neoplasm3
47COSM28746IDH1central nervous system,brain,other,neoplasm3
48COSM28746IDH1central nervous system,brain,other,neoplasm3
49COSM28746IDH1central nervous system,brain,other,neoplasm3
50COSM28746IDH1central nervous system,brain,other,neoplasm3

Expression for genes affiliated with Ganglioglioma

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Search GEO for disease gene expression data for Ganglioglioma.

Pathways for genes affiliated with Ganglioglioma

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Pathways related to Ganglioglioma according to GeneCards Suite gene sharing:

(show all 18)
idSuper pathwaysScoreTop Affiliating Genes
19.6BRAF, TP53
29.3CHGA, TSC2
39.3GFAP, MAP2, SYP
49.3TP53, TSC1, TSC2
5
Show member pathways
9.3TP53, TSC1, TSC2
6
Show member pathways
9.3TP53, TSC1, TSC2
7
Show member pathways
9.3TP53, TSC1, TSC2
8
Show member pathways
9.3TP53, TSC1, TSC2
9
Show member pathways
9.2SMARCB1, TSC1, TSC2
109.2BRAF, TSC1, TSC2
11
Show member pathways
9.1BRAF, MAP2, TP53
12
Show member pathways
8.8BRAF, TP53, TSC1, TSC2
13
Show member pathways
8.8BRAF, TP53, TSC1, TSC2
148.8BRAF, TP53, TSC1, TSC2
15
Show member pathways
8.8BRAF, TP53, TSC1, TSC2
168.8BRAF, TP53, TSC1, TSC2
178.7MAP2, TP53, TSC1, TSC2
18
Show member pathways
8.4CHGA, TP53, TSC1, TSC2

GO Terms for genes affiliated with Ganglioglioma

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Biological processes related to Ganglioglioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein localizationGO:00081049.8TP53, TSC2
2negative regulation of insulin receptor signaling pathwayGO:00466279.5TSC1, TSC2

Sources for Ganglioglioma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet