MCID: GNG004
MIFTS: 54

Ganglioglioma malady

Rare diseases, Neuronal diseases, Cancer diseases categories
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Summaries for Ganglioglioma

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NIH Rare Diseases:42 A ganglioglioma is a rare type of brain tumor, accounting for approximately 1% of all brain tumors.  gangliogliomas occur when a single cell in the brain starts to divide into more cells, forming a tumor.  this can occur when the cell randomly acquires changes (mutations) in genes that regulate how a cell divides.  most gangliogliomas grow slowly and are considered benign.  however, up to 10% of gangliogliomas may grow more rapidly and become malignant, meaning the tumor affects the surrounding brain tissue.    the main treatment for ganglioglioma is removal of the entire tumor during surgery.  if the entire tumor is not removed, it has the potential to recur and may require additional surgery or treatments, such as radiation therapy or chemotherapy.  unfortunately, because gangliogliomas are quite rare, there is limited information to show that radiation therapy or chemotherapy are effective treatments for this condition. last updated: 7/11/2011

MalaCards based summary: Ganglioglioma, also known as childhood ganglioglioma, is related to dysembryoplastic neuroepithelial tumor and giant cell glioblastoma. An important gene associated with Ganglioglioma is S100B (S100 calcium binding protein B), and among its related pathways are Nuclear signaling by ERBB4 and Cytoplasmic microtubules. The compounds eosin and 2,3-cyclic nucleotide have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and temporal lobe, and related mouse phenotypes are nervous system and normal.

Disease Ontology:8 A cell type benign neoplasm that has material basis in glial-type cells.

Wikipedia:65 Ganglioglioma is a tumour that arises from ganglion cells in the central nervous system. Gangliogliomas... more...

Aliases & Classifications for Ganglioglioma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 62UMLS, 57SNOMED-CT, 39NCIt, 34MeSH, 63UMLS via Orphanet
See all sources

Ganglioglioma, Aliases & Descriptions:

Name: Ganglioglioma 8 42 10 44 48 62
Childhood Ganglioglioma 8 62
Adult Ganglioglioma 8 62
 
Mixed Cell Tumors Containing Both Neural Ganglionic Cells and Neural Glial Cell Components 42
Cns Ganglioglioma 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology8 DOID:5078
NCIt39 C3788
SNOMED-CT57 89880005
MeSH34 D018303
UMLS via Orphanet63 C0206716

Related Diseases for Ganglioglioma

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Diseases related to Ganglioglioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 121)
idRelated DiseaseScoreTop Affiliating Genes
1dysembryoplastic neuroepithelial tumor31.2SYP
2giant cell glioblastoma30.7GFAP
3rhabdoid tumor30.5SYP, ACTC1
4anaplastic ependymoma30.4GFAP, S100B
5glioblastoma multiforme30.3NES, MYCN, GFAP
6meningioma30.3GFAP, SYP, S100B
7neuroblastoma30.2MYCN, SYP
8ganglioneuroblastoma30.0MYCN, SYP, S100B
9astrocytoma30.0GFAP, APOD, NES, SYP, S100B
10tuberous sclerosis30.0GFAP, NES, SYP, S100B
11oligodendroglioma29.9SYP, APOD, GFAP
12glioblastoma29.9GFAP, APOD, MYCN, NES, S100B
13ependymoma29.8S100B, SYP, NES, GFAP
14alzheimer's disease29.6GFAP, APOD, SYP, S100B
15pilocytic astrocytoma29.6GFAP, APOD, NES, SYP, S100B
16neurofibroma29.4APOD, ACTC1, SYP, S100B
17desmoplastic infantile ganglioglioma10.8
18anaplastic ganglioglioma10.7
19cerebritis10.5
20neuronitis10.5
21medulloepithelioma10.5SYP
22choroid plexus papilloma10.5GFAP
23melanotic neuroectodermal tumor10.5SYP
24histiocytosis10.5S100B
25cerebral primitive neuroectodermal tumor10.4MYCN
26pleomorphic xanthoastrocytoma10.4
27myxopapillary ependymoma10.3S100B, GFAP
28gangliocytoma10.3
29neurofibromatosis10.3
30choroid plexus carcinoma10.3GFAP, S100B
31gemistocytic astrocytoma10.3GFAP, S100B
32syringoma10.3S100B, GFAP
33subependymal giant cell astrocytoma10.3SYP, S100B
34olfactory neuroblastoma10.3SYP, S100B
35binswanger's disease10.3SYP, GFAP
36central neurocytoma10.3GFAP, SYP
37granular cell tumor10.3SYP, S100B
38chordoma10.3S100B, GFAP
39pineoblastoma10.3SYP, GFAP
40atypical teratoid rhabdoid tumor10.2
41desmoplastic infantile astrocytoma/ganglioglioma10.2
42creutzfeldt-jakob disease10.2S100B, NES
43neuroendocrine carcinoma10.2S100B, SYP
44male breast cancer10.2APOD, SYP
45desmoplastic infantile astrocytoma10.2
46nasal ganglioglioma10.2
47prion disease10.2SYP, GFAP
48papillary ependymoma10.1GFAP, SYP, S100B
49pineocytoma10.1S100B, SYP, GFAP
50spindle cell sarcoma10.1ACTC1, S100B

Graphical network of the top 20 diseases related to Ganglioglioma:



Diseases related to ganglioglioma

Symptoms for Ganglioglioma

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Drugs & Therapeutics for Ganglioglioma

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Drug clinical trials:

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Search NIH Clinical Center for Ganglioglioma

Genetic Tests for Ganglioglioma

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Anatomical Context for Ganglioglioma

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MalaCards organs/tissues related to Ganglioglioma:

32
Brain, Spinal cord, Temporal lobe, Cerebellum, Pineal, Cortex, Thalamus, Parietal lobe, Occipital lobe, Medulla oblongata

Animal Models for Ganglioglioma or affiliated genes

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MGI Mouse Phenotypes related to Ganglioglioma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.9SYP, NES, MYCN, APOD, GFAP
2MP:00028737.8S100B, SYP, ACTC1, MYCN, GFAP
3MP:00053867.7GFAP, APOD, MYCN, NES, S100B

Publications for Ganglioglioma

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Articles related to Ganglioglioma:

(show top 50)    (show all 387)
idTitleAuthorsYear
1
Greater extent of resection improves ganglioglioma recurrence-free survival in children: a volumetric analysis. (24625425)
2014
2
Ganglioglioma mimicking the cerebral abscess in advanced age: a case report. (24101283)
2013
3
Hemorrhagic ganglioglioma of the posterior fossa: case report. (24192758)
2013
4
Ganglioglioma with anaplastic transformation. (22990737)
2012
5
Anaplastic ganglioglioma: a very rare intramedullary spinal cord tumor. (22922809)
2012
6
Composite ganglioglioma/dysembryoplastic neuroepithelial tumor: a clinicopathologic study of 8 cases. (22221701)
2012
7
Strong desmin expression in a congenital desmoplastic infantile ganglioglioma mimicking pleomorphic rhadomyosarcoma: a case report including ultrastructural and cytogenetic evaluation and review of the literature. (22899016)
2012
8
Ganglioglioma of the thoracolumbar spinal cord in a patient with neurofibromatosis type 1: a case report and literature review. (22041518)
2011
9
Intraventricular ganglioglioma with bleed: a rare case report. (20644285)
2010
10
Primary malignant ganglioglioma of the dorsolumbar spine (D11-L1). (20817466)
2010
11
Ganglioglioma in the cerebellopontine angle of an adult without seizures. (19772036)
2009
12
Minimum apparent diffusion coefficient for the differential diagnosis of ganglioglioma. (19138470)
2009
13
Desmoplastic infantile ganglioglioma with a malignant course. (18352812)
2008
14
Anaplastic ganglioglioma in a middle-aged woman: a case report with a review of the literature. (17923741)
2007
15
Desmoplastic infantile ganglioglioma/astrocytoma with cerebrospinal metastasis. (17386372)
2007
16
Malignant and benign ganglioglioma: a pathological and molecular study. (17259542)
2007
17
Spinal cord ganglioglioma presenting as acute paraparesis. (15946791)
2006
18
Anaplastic ganglioglioma of the cerebellopontine angle. Case report. (16308520)
2005
19
Desmoplastic non-infantile ganglioglioma. (15875908)
2005
20
Cyanotic breath-holding spell: a life-threatening complication after radical resection of a cervicomedullary ganglioglioma. (15942280)
2005
21
Conventional MR imaging with simultaneous measurements of cerebral blood volume and vascular permeability in ganglioglioma. (15172052)
2004
22
Residents' corner. Answer to case of the month #96. Right frontal lobe ganglioglioma. (15131935)
2004
23
Desmoplastic infantile astrocytoma and ganglioglioma: a search for genomic characteristics. (12111357)
2002
24
Desmoplastic infantile ganglioglioma: a potentially malignant tumor? (12409729)
2002
25
Congenital ganglioglioma. (12003306)
2002
26
Ganglioglioma of the lateral ventricle presenting with blepharospasm - case report and review of the literature. (11386809)
2001
27
Intraventricular trigonal ganglioglioma arising from the choroid plexus. (11685629)
2001
28
Malignant transformation of a gangliocytoma/ganglioglioma into a glioblastoma multiforme: a molecular genetic analysis. Case report. (11453385)
2001
29
Intracranial ganglioglioma. (10769518)
2000
30
Tuberin expression in ganglioglioma. (10808554)
2000
31
Coexistence of a ganglioglioma and Rasmussen's encephalitis. (10461077)
1999
32
Malignant glial tumor arising from the site of a previous hamartoma/ganglioglioma: coincidence or malignant transformation? (10352415)
1999
33
Intraventricular ganglioglioma: case report. (9689626)
1998
34
Telomere associations in desmoplastic infantile ganglioglioma. (8956861)
1996
35
Image interpretation session. Ganglioglioma. (7899606)
1995
36
Anaplastic ganglioglioma: case report and review of the literature. (7984264)
1994
37
Ganglioglioma of the mastoid region: a case report. (8455853)
1993
38
Chronic neurological dysfunction attributable to a ganglioglioma. (1398525)
1992
39
Cerebral ganglioglioma with long history and unusual prominence of the mesenchymal elements. Case report. (1297930)
1992
40
Hemifacial spasm in an infant due to fourth ventricular ganglioglioma. Case report. (2045898)
1991
41
Cerebral ganglioglioma and neurofibromatosis type I. Case report and review of the literature. (1922756)
1991
42
Intracranial ganglioglioma: MR imaging. (2119137)
1990
43
Ganglioglioma containing osseous tissue and neurofibrillary tangles. (3132128)
1988
44
Ganglioglioma of the spinal cord in a calf. (3576915)
1987
45
The occurrence of catecholamine neurons in a parietal lobe ganglioglioma. (2887276)
1987
46
Unilateral hemispheric ganglioglioma with infantile spasms. (7425564)
1980
47
Cerebellar ganglioglioma. Case report. (479941)
1979
48
Cerebellar ganglioglioma in a child. (219154)
1979
49
Ganglioglioma of the cerebellum: angiographic findings. (951566)
1976
50
Intraocular ganglioglioma in a dog. (5393729)
1969

Variations for Ganglioglioma

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Expression for genes affiliated with Ganglioglioma

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Expression patterns in normal tissues for genes affiliated with Ganglioglioma

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Pathways for genes affiliated with Ganglioglioma

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Pathways related to Ganglioglioma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7S100B, GFAP
2
Show member pathways
Cytoskeleton remodeling Neurofilaments60
9.5NES, GFAP
38.7S100B, SYP, MYCN, GFAP

Compounds for genes affiliated with Ganglioglioma

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Compounds related to Ganglioglioma according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1eosin4410.0GFAP, S100B
22,3-cyclic nucleotide4410.0GFAP, S100B
3n-acetylaspartate449.9GFAP, SYP
4homovanillic acid44 2410.8MYCN, GFAP
5l-amino acid449.8SYP, S100B
6orcein449.6ACTC1, S100B
72-mercaptoethanol449.5NES, GFAP
8acth449.5SYP, GFAP, S100B
9catecholamine449.5MYCN, SYP, S100B
10streptozotocin449.5GFAP, SYP, NES
11ganglioside449.5GFAP, NES, SYP
12kainate44 2810.4SYP, GFAP, NES
13ethanol44 50 24 1112.4SYP, GFAP, S100B
14etoposide44 50 61 1112.3S100B, MYCN, SYP
15dutp449.3SYP, GFAP
16agarose449.3S100B, MYCN, APOD
17mucicarmine449.3SYP, ACTC1, S100B
18forskolin44 50 1111.2GFAP, SYP, S100B
19b 723449.2ACTC1, S100B, SYP
20dbc-amp449.1GFAP, SYP, MYCN, S100B
21potassium44 24 1111.1SYP, GFAP, S100B
22choline44 24 1111.1S100B, SYP, GFAP, NES
23gaba449.1S100B, SYP, GFAP, NES
24acetylcholine44 50 28 24 1113.1S100B, NES, GFAP, SYP
25phospholipid449.1APOD, S100B, SYP
26bromodeoxyuridine449.1GFAP, S100B, NES, MYCN
27leucine449.1GFAP, MYCN, SYP, S100B
28glutamate449.0SYP, GFAP, NES, S100B
29matrigel448.9ACTC1, NES, GFAP
30nitric oxide44 24 1110.9S100B, SYP, NES, MYCN
31s 100448.9S100B, SYP, GFAP, ACTC1
32reticulin448.9GFAP, ACTC1, SYP, S100B
33hematoxylin448.9S100B, SYP, ACTC1, GFAP
34formaldehyde44 249.8SYP, S100B, GFAP, ACTC1
35glycogen44 249.8S100B, SYP, ACTC1, GFAP
36iron44 249.7GFAP, MYCN, ACTC1, S100B
37dexamethasone44 50 28 1111.7SYP, ACTC1, S100B, GFAP
38dopamine44 28 24 1111.6SYP, S100B, MYCN, NES, GFAP
39oxygen44 249.5GFAP, S100B, NES, ACTC1
40steroid448.5S100B, SYP, APOD, ACTC1
41lipid448.5SYP, S100B, NES, APOD, GFAP
42creatinine448.2S100B, SYP, APOD, GFAP, ACTC1
43testosterone44 61 24 1111.2GFAP, S100B, ACTC1, SYP, APOD
44glucose448.1ACTC1, S100B, NES, APOD, GFAP
45vegf447.8MYCN, S100B, GFAP, NES, ACTC1, SYP
46tyrosine447.8SYP, ACTC1, MYCN, NES, S100B, GFAP
47progesterone44 28 61 24 1111.7GFAP, S100B, SYP, ACTC1, NES, APOD
48estrogen447.7S100B, SYP, GFAP, APOD, NES, ACTC1
49paraffin447.2S100B, GFAP, SYP, ACTC1, NES, MYCN
50retinoic acid44 248.2NES, ACTC1, SYP, S100B, MYCN, APOD

GO Terms for genes affiliated with Ganglioglioma

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Cellular components related to Ganglioglioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.5NES, GFAP

Biological processes related to Ganglioglioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1central nervous system developmentGO:0074179.6S100B, NES
2regulation of neuronal synaptic plasticityGO:0481689.5S100B, SYP
3long-term synaptic potentiationGO:0602919.4S100B, GFAP

Molecular functions related to Ganglioglioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cholesterol bindingGO:0154859.4SYP, APOD

Products for genes affiliated with Ganglioglioma

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Sources for Ganglioglioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet