MCID: GNG004
MIFTS: 46

Ganglioglioma malady

Rare diseases, Neuronal diseases, Cancer diseases categories

Summaries for Ganglioglioma

About this section


NIH Rare Diseases:41 A ganglioglioma is a rare type of brain tumor, accounting for approximately 1% of all brain tumors.  gangliogliomas occur when a single cell in the brain starts to divide into more cells, forming a tumor.  this can occur when the cell randomly acquires changes (mutations) in genes that regulate how a cell divides.  most gangliogliomas grow slowly and are considered benign.  however, up to 10% of gangliogliomas may grow more rapidly and become malignant, meaning the tumor affects the surrounding brain tissue.    the main treatment for ganglioglioma is removal of the entire tumor during surgery.  if the entire tumor is not removed, it has the potential to recur and may require additional surgery or treatments, such as radiation therapy or chemotherapy.  unfortunately, because gangliogliomas are quite rare, there is limited information to show that radiation therapy or chemotherapy are effective treatments for this condition. last updated: 7/11/2011

MalaCards based summary: Ganglioglioma, also known as childhood ganglioglioma, is related to dysembryoplastic neuroepithelial tumor and giant cell glioblastoma. An important gene associated with Ganglioglioma is S100B (S100 calcium binding protein B), and among its related pathways are Nuclear signaling by ERBB4 and Cytoplasmic microtubules. The compounds eosin and 2,3-cyclic nucleotide have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and temporal lobe, and related mouse phenotypes are nervous system and normal.

Disease Ontology:9 A cell type benign neoplasm that has material basis in glial-type cells.

Wikipedia:63 Ganglioglioma is a tumour that arises from ganglion cells in the central nervous system. Gangliogliomas... more...

Aliases & Classifications for Ganglioglioma

About this section
Sources:
9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 43Novoseek, 47Orphanet, 60UMLS, 33MeSH, 55SNOMED-CT, 38NCIt, 61UMLS via Orphanet
See all sources

Ganglioglioma, Aliases & Descriptions:

Name: Ganglioglioma 9 41 11 43 47 60
Childhood Ganglioglioma 9 60
Adult Ganglioglioma 9 60
 
Mixed Cell Tumors Containing Both Neural Ganglionic Cells and Neural Glial Cell Components 41
Cns Ganglioglioma 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology9 DOID:5078
MeSH33 D018303
NCIt38 C3788
SNOMED-CT55 89880005
Orphanet47 251949
UMLS via Orphanet61 C0206716

Related Diseases for Ganglioglioma

About this section

Diseases related to Ganglioglioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 127)
idRelated DiseaseScoreTop Affiliating Genes
1dysembryoplastic neuroepithelial tumor31.1SYP
2giant cell glioblastoma30.6GFAP
3rhabdoid tumor30.5ACTC1, SYP
4anaplastic ependymoma30.4S100B, GFAP
5glioblastoma multiforme30.3NES, MYCN, GFAP
6neuroblastoma30.2SYP, MYCN
7tuberous sclerosis30.1GFAP, NES, SYP, S100B
8ganglioneuroblastoma30.0S100B, SYP, MYCN
9astrocytoma30.0S100B, SYP, NES, APOD, GFAP
10oligodendroglioma29.9SYP, APOD, GFAP
11glioblastoma29.9GFAP, S100B, NES, MYCN, APOD
12ependymoma29.8S100B, GFAP, SYP, NES
13pilocytic astrocytoma29.6NES, SYP, S100B, APOD, GFAP
14neurofibroma29.4S100B, APOD, SYP, ACTC1
15adenocarcinoma29.3SYP, MYCN, ACTC1, NES
16desmoplastic infantile ganglioglioma10.8
17anaplastic ganglioglioma10.7
18cerebritis10.5
19neuronitis10.5
20medulloepithelioma10.5SYP
21melanotic neuroectodermal tumor10.4SYP
22choroid plexus papilloma10.4GFAP
23histiocytosis10.4S100B
24cerebral primitive neuroectodermal tumor10.4MYCN
25pleomorphic xanthoastrocytoma10.4
26neurofibromatosis10.4
27myxopapillary ependymoma10.3S100B, GFAP
28gangliocytoma10.3
29choroid plexus carcinoma10.3S100B, GFAP
30gemistocytic astrocytoma10.3S100B, GFAP
31syringoma10.3GFAP, S100B
32subependymal giant cell astrocytoma10.3SYP, S100B
33olfactory neuroblastoma10.3SYP, S100B
34binswanger's disease10.3GFAP, SYP
35central neurocytoma10.3SYP, GFAP
36granular cell tumor10.3SYP, S100B
37pineoblastoma10.3SYP, GFAP
38chordoma10.3S100B, GFAP
39neurofibromatosis, type 110.2
40atypical teratoid rhabdoid tumor10.2
41nasal ganglioglioma10.2
42desmoplastic infantile astrocytoma/ganglioglioma10.2
43creutzfeldt-jakob disease10.2NES, S100B
44breast cancer10.2SYP, APOD
45desmoplastic infantile astrocytoma10.2
46brain disease10.1GFAP, SYP
47papillary ependymoma10.1SYP, GFAP, S100B
48pineocytoma10.1SYP, S100B, GFAP
49paraganglioma10.1S100B, SYP, GFAP
50spindle cell sarcoma10.1S100B, ACTC1

Graphical network of the top 20 diseases related to Ganglioglioma:



Diseases related to ganglioglioma

Symptoms for Ganglioglioma

About this section

Drugs & Therapeutics for Ganglioglioma

About this section

Drug clinical trials:

Search ClinicalTrials for Ganglioglioma

Search NIH Clinical Center for Ganglioglioma

Genetic Tests for Ganglioglioma

About this section

Anatomical Context for Ganglioglioma

About this section

MalaCards organs/tissues related to Ganglioglioma:

31
Brain, Spinal cord, Temporal lobe, Cerebellum, Pineal, Cortex, Thalamus, Colon, Myeloid, Parietal lobe, Occipital lobe, Medulla oblongata

Animal Models for Ganglioglioma or affiliated genes

About this section

MGI Mouse Phenotypes related to Ganglioglioma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.9SYP, NES, MYCN, APOD, GFAP
2MP:00028737.8S100B, SYP, ACTC1, MYCN, GFAP
3MP:00053867.7GFAP, APOD, MYCN, NES, S100B

Publications for Ganglioglioma

About this section

Articles related to Ganglioglioma:

(show top 50)    (show all 391)
idTitleAuthorsYear
1
An Unusual Case of Constitutional Mismatch Repair Deficiency Syndrome With Anaplastic Ganglioglioma, Colonic Adenocarcinoma, Osteosarcoma, Acute Myeloid Leukemia, and Signs of Neurofibromatosis Type 1: Case Report. (25850602)
2015
2
Anaplastic ganglioglioma: a report of three cases and review of the literature. (25862009)
2015
3
Response of recurrent BRAFV600E mutated ganglioglioma to Vemurafenib as single agent. (25524464)
2014
4
Ganglioglioma mimicking the cerebral abscess in advanced age: a case report. (24101283)
2013
5
Hemorrhagic ganglioglioma of the posterior fossa: case report. (24192758)
2013
6
Ganglioglioma with anaplastic transformation. (22990737)
2012
7
Anaplastic ganglioglioma: a very rare intramedullary spinal cord tumor. (22922809)
2012
8
Composite ganglioglioma/dysembryoplastic neuroepithelial tumor: a clinicopathologic study of 8 cases. (22221701)
2012
9
Strong desmin expression in a congenital desmoplastic infantile ganglioglioma mimicking pleomorphic rhadomyosarcoma: a case report including ultrastructural and cytogenetic evaluation and review of the literature. (22899016)
2012
10
Intraventricular ganglioglioma with bleed: a rare case report. (20644285)
2010
11
Primary malignant ganglioglioma of the dorsolumbar spine (D11-L1). (20817466)
2010
12
Ganglioglioma in the cerebellopontine angle of an adult without seizures. (19772036)
2009
13
Minimum apparent diffusion coefficient for the differential diagnosis of ganglioglioma. (19138470)
2009
14
Desmoplastic infantile ganglioglioma with a malignant course. (18352812)
2008
15
Anaplastic ganglioglioma in a middle-aged woman: a case report with a review of the literature. (17923741)
2007
16
Desmoplastic infantile ganglioglioma/astrocytoma with cerebrospinal metastasis. (17386372)
2007
17
Malignant and benign ganglioglioma: a pathological and molecular study. (17259542)
2007
18
Spinal cord ganglioglioma presenting as acute paraparesis. (15946791)
2006
19
Anaplastic ganglioglioma of the cerebellopontine angle. Case report. (16308520)
2005
20
Desmoplastic non-infantile ganglioglioma. (15875908)
2005
21
Cyanotic breath-holding spell: a life-threatening complication after radical resection of a cervicomedullary ganglioglioma. (15942280)
2005
22
Conventional MR imaging with simultaneous measurements of cerebral blood volume and vascular permeability in ganglioglioma. (15172052)
2004
23
Residents' corner. Answer to case of the month #96. Right frontal lobe ganglioglioma. (15131935)
2004
24
Desmoplastic infantile astrocytoma and ganglioglioma: a search for genomic characteristics. (12111357)
2002
25
Desmoplastic infantile ganglioglioma: a potentially malignant tumor? (12409729)
2002
26
Congenital ganglioglioma. (12003306)
2002
27
Ganglioglioma of the lateral ventricle presenting with blepharospasm - case report and review of the literature. (11386809)
2001
28
Intraventricular trigonal ganglioglioma arising from the choroid plexus. (11685629)
2001
29
Malignant transformation of a gangliocytoma/ganglioglioma into a glioblastoma multiforme: a molecular genetic analysis. Case report. (11453385)
2001
30
Intracranial ganglioglioma. (10769518)
2000
31
Tuberin expression in ganglioglioma. (10808554)
2000
32
Coexistence of a ganglioglioma and Rasmussen's encephalitis. (10461077)
1999
33
Intraventricular ganglioglioma: case report. (9689626)
1998
34
Telomere associations in desmoplastic infantile ganglioglioma. (8956861)
1996
35
Image interpretation session. Ganglioglioma. (7899606)
1995
36
Anaplastic ganglioglioma: case report and review of the literature. (7984264)
1994
37
Ganglioglioma of the mastoid region: a case report. (8455853)
1993
38
Chronic neurological dysfunction attributable to a ganglioglioma. (1398525)
1992
39
Cerebral ganglioglioma with long history and unusual prominence of the mesenchymal elements. Case report. (1297930)
1992
40
Hemifacial spasm in an infant due to fourth ventricular ganglioglioma. Case report. (2045898)
1991
41
Cerebral ganglioglioma and neurofibromatosis type I. Case report and review of the literature. (1922756)
1991
42
Intracranial ganglioglioma: MR imaging. (2119137)
1990
43
Ganglioglioma containing osseous tissue and neurofibrillary tangles. (3132128)
1988
44
Ganglioglioma of the spinal cord in a calf. (3576915)
1987
45
The occurrence of catecholamine neurons in a parietal lobe ganglioglioma. (2887276)
1987
46
Unilateral hemispheric ganglioglioma with infantile spasms. (7425564)
1980
47
Cerebellar ganglioglioma. Case report. (479941)
1979
48
Cerebellar ganglioglioma in a child. (219154)
1979
49
Ganglioglioma of the cerebellum: angiographic findings. (951566)
1976
50
Intraocular ganglioglioma in a dog. (5393729)
1969

Variations for Ganglioglioma

About this section

Expression for genes affiliated with Ganglioglioma

About this section
Search GEO for disease gene expression data for Ganglioglioma.

Pathways for genes affiliated with Ganglioglioma

About this section

Pathways related to Ganglioglioma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7S100B, GFAP
28.7S100B, SYP, MYCN, GFAP

Compounds for genes affiliated with Ganglioglioma

About this section

Compounds related to Ganglioglioma according to GeneCards Suite gene sharing:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1eosin4310.0GFAP, S100B
22,3-cyclic nucleotide4310.0S100B, GFAP
3n-acetylaspartate439.9GFAP, SYP
4homovanillic acid43 2410.8GFAP, MYCN
5l-amino acid439.8S100B, SYP
6orcein439.6S100B, ACTC1
72-mercaptoethanol439.5NES, GFAP
8acth439.5S100B, SYP, GFAP
9streptozotocin439.5SYP, NES, GFAP
10catecholamine439.5MYCN, SYP, S100B
11ganglioside439.5GFAP, NES, SYP
12kainate43 2810.5GFAP, NES, SYP
13ethanol43 49 24 1212.4GFAP, SYP, S100B
14etoposide43 49 59 1212.3MYCN, SYP, S100B
15dutp439.3SYP, GFAP
16agarose439.3S100B, MYCN, APOD
17mucicarmine439.3S100B, SYP, ACTC1
18forskolin43 49 1211.2S100B, SYP, GFAP
19b 723439.2S100B, SYP, ACTC1
20dbc-amp439.1S100B, SYP, MYCN, GFAP
21potassium43 24 1211.1GFAP, SYP, S100B
22choline43 24 1211.1S100B, SYP, NES, GFAP
23gaba439.1GFAP, NES, SYP, S100B
24acetylcholine43 49 28 24 1213.1GFAP, NES, SYP, S100B
25phospholipid439.1APOD, SYP, S100B
26bromodeoxyuridine439.1GFAP, MYCN, NES, S100B
27leucine439.1GFAP, MYCN, SYP, S100B
28glutamate439.0S100B, SYP, NES, GFAP
29matrigel438.9ACTC1, NES, GFAP
30nitric oxide43 24 1210.9MYCN, NES, SYP, S100B
31s 100438.9S100B, SYP, ACTC1, GFAP
32reticulin438.9GFAP, ACTC1, SYP, S100B
33hematoxylin438.9GFAP, ACTC1, SYP, S100B
34formaldehyde43 249.8GFAP, ACTC1, SYP, S100B
35glycogen43 249.8S100B, SYP, ACTC1, GFAP
36iron43 249.7S100B, ACTC1, MYCN, GFAP
37dexamethasone43 49 28 1211.7GFAP, ACTC1, SYP, S100B
38dopamine43 28 24 1211.6GFAP, MYCN, NES, SYP, S100B
39oxygen43 249.5S100B, ACTC1, NES, GFAP
40steroid438.5APOD, ACTC1, SYP, S100B
41lipid438.5GFAP, APOD, NES, SYP, S100B
42creatinine438.2GFAP, APOD, ACTC1, SYP, S100B
43testosterone43 59 24 1211.2GFAP, APOD, ACTC1, SYP, S100B
44glucose438.1GFAP, APOD, NES, ACTC1, S100B
45vegf437.8GFAP, MYCN, NES, ACTC1, SYP, S100B
46tyrosine437.8GFAP, MYCN, NES, ACTC1, SYP, S100B
47progesterone43 28 59 24 1211.7GFAP, APOD, NES, ACTC1, SYP, S100B
48estrogen437.7GFAP, APOD, NES, ACTC1, SYP, S100B
49paraffin437.2S100B, GFAP, APOD, MYCN, NES, ACTC1
50retinoic acid43 248.2GFAP, APOD, MYCN, NES, ACTC1, SYP

GO Terms for genes affiliated with Ganglioglioma

About this section

Cellular components related to Ganglioglioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00058829.5NES, GFAP

Biological processes related to Ganglioglioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1central nervous system developmentGO:00074179.6S100B, NES
2regulation of neuronal synaptic plasticityGO:00481689.5S100B, SYP
3long-term synaptic potentiationGO:00602919.4S100B, GFAP

Molecular functions related to Ganglioglioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cholesterol bindingGO:00154859.4SYP, APOD

Products for genes affiliated with Ganglioglioma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Ganglioglioma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet