MCID: GNG004
MIFTS: 60

Ganglioglioma malady

Neuronal diseases, Cancer diseases categories

Summaries for Ganglioglioma

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 A ganglioglioma is a rare type of brain tumor, accounting for approximately 1% of all brain tumors.  gangliogliomas occur when a single cell in the brain starts to divide into more cells, forming a tumor.  this can occur when the cell randomly acquires changes (mutations) in genes that regulate how a cell divides.  most gangliogliomas grow slowly and are considered benign.  however, up to 10% of gangliogliomas may grow more rapidly and become malignant, meaning the tumor affects the surrounding brain tissue.    the main treatment for ganglioglioma is removal of the entire tumor during surgery.  if the entire tumor is not removed, it has the potential to recur and may require additional surgery or treatments, such as radiation therapy or chemotherapy.  unfortunately, because gangliogliomas are quite rare, there is limited information to show that radiation therapy or chemotherapy are effective treatments for this condition. last updated: 7/11/2011

MalaCards: Ganglioglioma, also known as childhood ganglioglioma, is related to gangliocytoma and neurofibromatosis. An important gene associated with Ganglioglioma is S100B (S100 calcium binding protein B), and among its related pathways are Inhibition of TSC complex formation by PKB and Development IGF-RI signaling. The compounds estrogen and glutamate have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and temporal lobe, and related mouse phenotypes are integument and no phenotypic analysis.

Wikipedia:63 Ganglioglioma is a tumour that arises from ganglion cells in the central nervous system. Gangliogliomas... more...

Aliases & Classifications for Ganglioglioma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

ganglioglioma 8 42 10 44 48 60
childhood ganglioglioma 8 60
adult ganglioglioma 8 60
mixed cell tumors containing both neural ganglionic cells and neural glial cell components 42
ganglioglioma, no icd-o subtype 8


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Disease Ontology8 DOID:5078
MeSH34 D018303
SNOMED-CT56 89880005
NCIt39 C3788

Related Diseases for Ganglioglioma

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17GeneCards, 18GeneDecks
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Diseases related to Ganglioglioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 201)
idRelated DiseaseScoreTop Affiliating Genes
1gangliocytoma30.4SYP
2neurofibromatosis30.4TSC2, TSC1, ENO2, S100B
3astrocytoma30.4TSC2, TSC1, GFAP, NTRK1, SYP, NES
4dysembryoplastic neuroepithelial tumor30.3SYP
5temporal lobe epilepsy30.2GFAP, GRIN1, PVALB
6glioblastoma multiforme30.2BCL2L1, TSC1, GFAP, MYCN, NTRK1, NES
7hydrocephalus30.0TSC1, NES
8meningioma30.0TSC1, GFAP, SYP, S100B, CALB2
9tuberous sclerosis30.0TSC2, TSC1, GFAP, SYP, DCX, NES
10gliosarcoma29.8GFAP
11hemangioma29.8ACTC1
12encephalitis29.8GFAP
13giant cell glioblastoma29.8GFAP
14status epilepticus29.8ENO2, DCX
15neurofibroma29.8ACTC1, SYP, APOD, S100B
16oligodendroglioma29.8TSC1, GFAP, SYP, DCX, APOD
17neuroblastoma29.8ENO2, TH, MYCN, NTRK1, SYP
18neuroendocrine tumor29.8ENO2, MYCN, NTRK1, CHGA, SYP
19ganglioneuroblastoma29.8ENO2, TH, MYCN, NTRK1, SYP, S100B
20epilepsy syndrome29.8TSC2, TSC1, GFAP, GRIN1, DCX, NES
21alzheimer's disease29.8CP, TSC2, TSC1, TH, GFAP, NTRK1
22cerebritis10.4
23neuronitis10.4
24anaplastic ganglioglioma10.4
25pleomorphic xanthoastrocytoma10.3
26desmoplastic infantile ganglioglioma10.2
27atypical teratoid rhabdoid tumor10.1
28desmoplastic infantile astrocytoma/ganglioglioma10.1
29cervicitis10.0
30primitive neuroectodermal tumor10.0
31nasal ganglioglioma10.0
32retinitis10.0DCX
33focal epilepsy10.0DCX
34phaeochromocytoma10.0CHGA
35pneumothorax10.0TSC1
36medulloepithelioma10.0SYP
37perivascular epithelioid cell tumor10.0TSC2
38melanotic neuroectodermal tumor10.0SYP
39somatostatinoma10.0CHGA
40fetal alcohol spectrum disorder10.0PVALB
41rhabdoid tumor10.0ACTC1, SYP
42sertoli-leydig cell tumor10.0CALB2
43dermatofibrosarcoma protuberans10.0ACTC1, S100B
44kidney rhabdoid cancer10.0TSC2
45scrapie10.0PVALB
46pancreatic islet cell tumors10.0CHGA, SYP
47hepatitis10.0CP, MYCN
48subependymoma10.0TSC2
49down syndrome10.0SNCA, S100B
50dysautonomia10.0SNCA

Graphical network of the top 20 diseases related to Ganglioglioma:



Diseases related to ganglioglioma

Clinical Features for Ganglioglioma

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Drugs & Therapeutics for Ganglioglioma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Ganglioglioma

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Anatomical Context for Ganglioglioma

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32MalaCards
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MalaCards organs/tissues related to Ganglioglioma:

32
Brain, Spinal cord, Temporal lobe, Cerebellum, Pineal, Cortex, Thalamus, Parietal lobe, Occipital lobe, Medulla oblongata

Animal Models for Ganglioglioma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Ganglioglioma:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.9BCL2L1, TSC2, TSC1, TH, S100B
2MP:00030129.6PVALB, SNCA, DCX, SYP, GRIN1, NTRK1
3MP:00028739.6PVALB, CALB2, S100B, SYP, GRIN1, NTRK1
4MP:00053859.5SNCA, CHGA, GRIN1, MYCN, GFAP, TH
5MP:00053899.3SNCA, DCX, CHGA, GRIN1, MYCN, TSC1
6MP:00053789.3GRIN1, CHGA, DCX, NES, SNCA, NTRK1
7MP:00053849.2MYCN, GRIN1, NES, SNCA, PVALB, GFAP
8MP:00107689.1GRIN1, CHGA, DCX, NES, SNCA, APOD
9MP:00053769.1MYCN, GRIN1, CHGA, SNCA, APOD, GFAP
10MP:00053868.9CP, PVALB, CALB2, S100B, APOD, SNCA
11MP:00036318.8SYP, DCX, NES, SNCA, APOD, CALB2

Publications for Ganglioglioma

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50PubMed
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Articles related to Ganglioglioma:

(show top 50)    (show all 372)
idTitleAuthorsYear
1
Ganglioglioma mimicking the cerebral abscess in advanced age: a case report. (24101283)
2013
2
BRAF(V600E) mutation is a negative prognosticator in pediatric ganglioglioma. (23609006)
2013
3
Occult pigmented ganglioglioma in an adult male with chronic posttraumatic epilepsy. (23254137)
2013
4
Bilateral ganglioglioma of the trigeminal nerve in an 83-year-old man. (23889676)
2013
5
Multimodal magnetic resonance imaging and 18F-L-dihydroxyphenylalanine positron emission tomography in early characterization of pseudoresponse and nonenhancing tumor progression in a pediatric patient with malignant transformation of ganglioglioma treated with bevacizumab. (23169514)
2013
6
Composite ganglioglioma/dysembryoplastic neuroepithelial tumor: a clinicopathologic study of 8 cases. (22221701)
2012
7
Long-term outcomes for low-grade intracranial ganglioglioma: 30-year experience from the Mayo Clinic. (22957524)
2012
8
Anaplastic ganglioglioma of the brainstem in an adult. (24028985)
2012
9
Atypical teratoid/rhabdoid tumor arising in a ganglioglioma: genetic characterization. (22082607)
2011
10
Ganglioglioma of the right lateral ventricle approached with neuronavigation and intraoperative DTI. Case report and literature review. (21993894)
2011
11
Malignant ganglioglioma: case report and review of literature. (20524041)
2011
12
Long-term follow-up of a non-infantile desmoplastic ganglioglioma. (20024887)
2010
13
Desmoplastic infantile and non-infantile ganglioglioma. Review of the literature. (21246390)
2010
14
Anaplastic Posterior Fossa Ganglioglioma in a Child: Case Report and Short Review of the Literature. (20496310)
2010
15
Floating-Harbor syndrome and intramedullary spinal cord ganglioglioma: case report and observations from the literature. (19764022)
2009
16
Desmoplastic non-infantile ganglioglioma: a low-grade tumor, report of two patients. (20139515)
2009
17
Intracranial ganglioglioma: clinicopathological and MRI findings in 16 patients. (18068794)
2008
18
Intraventricular ganglioglioma. (18829326)
2008
19
Ganglioglioma in the third ventricle: report on two cases. (17492319)
2007
20
Atypical teratoid/rhabdoid tumor evolving from an optic pathway ganglioglioma: case study. (16443951)
2006
21
Primary spinal anaplastic ganglioglioma. (17047418)
2006
22
Cyanotic breath-holding spell: a life-threatening complication after radical resection of a cervicomedullary ganglioglioma. (15942280)
2005
23
Overexpression of the human major vault protein in gangliogliomas. (12919388)
2003
24
Desmoplastic infantile astrocytoma and ganglioglioma: a search for genomic characteristics. (12111357)
2002
25
Genome-wide survey for chromosomal imbalances in ganglioglioma using comparative genomic hybridization. (11996800)
2002
26
Malignant transformation of a gangliocytoma/ganglioglioma into a glioblastoma multiforme: a molecular genetic analysis. Case report. (11453385)
2001
27
Tuberin expression in ganglioglioma. (10808554)
2000
28
Synaptophysin staining for ganglioglioma. (10219424)
1999
29
The significance of immunocytochemical markers, synaptophysin and neurofilaments in diagnosis of ganglioglioma. (10581850)
1999
30
Ganglioglioma and intractable epilepsy: clinical and neurophysiologic features and predictors of outcome after surgery. (9578050)
1998
31
Ganglioglioma of the neurohypophysis with secretion of vasopressin. (9831310)
1998
32
Congenital ganglioglioma: report of a case with an unusual imaging appearance. (9285737)
1997
33
Composite pleomorphic xanthoastrocytoma and ganglioglioma: report of four cases and review of the literature. (9236832)
1997
34
A novel splice site associated polymorphism in the tuberous sclerosis 2 (TSC2) gene may predispose to the development of sporadic gangliogliomas. (9210877)
1997
35
Central nervous system ganglioglioma. A clinicopathologic study. (8979472)
1996
36
Proliferative potential and malignant transformation of ganglioglioma: immunohistochemical studies by MIB-1 and p53 staining. (8867695)
1995
37
Desmoplastic infantile ganglioglioma--case report. (7692325)
1993
38
Chronic neurological dysfunction attributable to a ganglioglioma. (1398525)
1992
39
MRI features of spinal ganglioglioma. (1913309)
1991
40
Desmoplastic infantile ganglioglioma: CT and MR features. (1763751)
1991
41
Neuroendocrine markers in central nervous system neuronal tumors (gangliocytoma and ganglioglioma). (2922988)
1989
42
Ganglioglioma, a malignant tumor? Correlation with flow deoxyribonucleic acid cytometric analysis. (3226518)
1988
43
Congenital quadrantanopia with occipital lobe ganglioglioma. (3194068)
1988
44
Ganglioglioma of the spinal cord in a calf. (3576915)
1987
45
Intracerebral ganglioglioma. (3723174)
1986
46
Conus ganglioglioma in a 2 1/2-year-old boy. Case report. (3964847)
1985
47
Intracranial ganglioglioma: report of case. (6643148)
1983
48
Intractable facial pain associated with a ganglioglioma of the cervicomedullary junction: report of a case. (7099412)
1982
49
Microcystic ganglioglioma treated by partial removal and radiation therapy. (7093889)
1982
50
Ganglioglioma of the cerebellum: angiographic findings. (951566)
1976

Genetic Variations for Ganglioglioma

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Expression for genes affiliated with Ganglioglioma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ganglioglioma

Search GEO for disease gene expression data for Ganglioglioma.

Pathways for genes affiliated with Ganglioglioma

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53Reactome, 12EMD Millipore, 52R&D Systems, 4Cell Signaling Technology
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Compounds for genes affiliated with Ganglioglioma

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44Novoseek, 24HMDB, 49PharmGKB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience
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Compounds related to Ganglioglioma according to GeneCards/GeneDecks:

(show top 50)    (show all 110)
idCompoundScoreTop Affiliating Genes
1estrogen4410.6PVALB, CALB2, GFAP
2glutamate4410.5GRIN1, GFAP, SNCA, NTRK1
3reticulin4410.4ACTC1, S100B, GFAP, SYP
4vanillylmandelic acid44 2411.4MYCN, ENO2, TH, CHGA
5s 1004410.4ENO2, ACTC1, CHGA, SYP, S100B, GFAP
6b 7234410.3CALB2, ACTC1, S100B, CHGA, SYP
7homovanillic acid44 2411.3TH, GFAP, MYCN, ENO2, CHGA
8l-amino acid4410.3S100B, ENO2, TH, SYP, CHGA
9mucicarmine4410.3ACTC1, CALB2, S100B, SYP
10glucose4410.3TSC2, SNCA, GFAP, ACTC1, TSC1
11dexamethasone44 49 28 1113.2GFAP, TH, ENO2, BCL2L1, S100B
12hematoxylin4410.2ACTC1, ENO2, S100B, GFAP, CHGA, SYP
13glycogen44 2411.2TSC2, GFAP, CHGA, TSC1, ACTC1, SNCA
14mptp4410.2SNCA, GRIN1, GFAP, TH, BCL2L1
15kainate44 2811.2SYP, GRIN1, GFAP, TH, DCX, PVALB
16bromodeoxyuridine4410.2GFAP, CHGA, DCX, ENO2, S100B, NES
17creatinine4410.1CP, ACTC1, GFAP, NTRK1, CHGA, SYP
18dbc-amp4410.1SYP, S100B, ENO2, MYCN, GFAP
19nmda44 2811.1TH, BCL2L1, GRIN1, SYP, CP, GFAP
20ganglioside4410.1NES, SYP, NTRK1, GFAP, ENO2
21silver4410.1SYP, SNCA, CHGA, ENO2, CALB2, GFAP
225-hydroxytryptamine4410.1ENO2, SYP, CHGA, GFAP, CALB2, TH
23formaldehyde44 2411.1GFAP, CHGA, ENO2, ACTC1, TH, SYP
24steroid4410.1SYP, ACTC1, CALB2, TSC2
25catecholamine4410.1ENO2, TH, MYCN, NTRK1, CHGA, SYP
26ethanol44 49 11 2413.0GRIN1, SNCA, PVALB, CALB2, SYP, GFAP
27glutamine4410.0SNCA, SYP, CP, ENO2, GRIN1, S100B
28lactate4410.0CHGA, NTRK1, MYCN, TH, ENO2, CP
29norepinephrine44 11 2411.9S100B, ENO2, SNCA, TH, CHGA, GRIN1
30iron44 2410.9ENO2, ACTC1, TH, MYCN, S100B, GFAP
31gaba449.9CHGA, PVALB, S100B, NES, SYP, CALB2
32smcc449.9CHGA, ENO2, SYP
33adenylate449.9ENO2, S100B, CHGA, NTRK1, GFAP, TH
34etoposide44 49 59 1112.9CHGA, SYP, S100B, BCL2L1, MYCN, ENO2
35progesterone44 59 28 11 2413.8CALB2, S100B, APOD, NES, ACTC1, SYP
36choline44 11 2411.8ENO2, PVALB, CALB2, S100B, SNCA, NES
37acetylcholine44 49 28 11 2413.8CALB2, SNCA, NES, SYP, CHGA, NTRK1
38matrigel449.8NTRK1, CHGA, GFAP, NES, BCL2L1, ACTC1
39cysteine449.7BCL2L1, S100B, CP, GFAP, NTRK1, TH
40dopamine44 28 11 2412.7MYCN, NTRK1, GRIN1, CHGA, NES, SNCA
41nitric oxide44 11 2411.7SYP, CHGA, MYCN, NES, SNCA, CALB2
42lipid449.6NTRK1, SYP, NES, CHGA, SNCA, GRIN1
43testosterone44 59 11 2412.5CP, TSC2, ENO2, ACTC1, TH, GFAP
44oxygen44 2410.5NES, BCL2L1, NTRK1, CP, CHGA, GFAP
45retinoic acid44 2410.5S100B, APOD, NES, SYP, GRIN1, MYCN
46serine449.4PVALB, S100B, SNCA, DCX, SYP, CHGA
47vegf449.4MYCN, GFAP, TH, ACTC1, ENO2, TSC2
48calcium44 49 11 2412.3SNCA, PVALB, CALB2, ENO2, CHGA, ACTC1
49tyrosine449.1CHGA, SYP, NES, SNCA, S100B, PVALB
50paraffin449.1SYP, NES, SNCA, APOD, S100B, CALB2

GO Terms for genes affiliated with Ganglioglioma

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16Gene Ontology
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Cellular components related to Ganglioglioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1TSC1-TSC2 complexGO:03359610.4TSC1, TSC2
2terminal boutonGO:04319510.3TH, GRIN1, SNCA
3synaptic vesicleGO:00802110.2TH, GRIN1, SNCA
4growth coneGO:03042610.1TSC2, TSC1, SNCA
5dendriteGO:03042510.1TSC2, TH, NTRK1, GRIN1, APOD
6neuronal cell bodyGO:0430259.8S100B, APOD, NTRK1, TSC2
7cytosolGO:0058299.5SNCA, DCX, GFAP, TH, ACTC1, ENO2
8cytoplasmGO:0057379.2PVALB, CALB2, S100B, SNCA, NES, GFAP

Biological processes related to Ganglioglioma according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1cellular response to manganese ionGO:07128710.5TH, GRIN1
2long-term synaptic potentiationGO:06029110.4S100B, SNCA, GFAP
3regulation of long-term neuronal synaptic plasticityGO:04816910.4GRIN1, SYP, SNCA
4cellular response to nicotineGO:07131610.4TH, NTRK1
5negative regulation of platelet-derived growth factor receptor signaling pathwayGO:01064210.4SNCA, APOD
6cerebral cortex developmentGO:02198710.3GRIN1, TH, TSC1
7negative regulation of cell sizeGO:04579210.3TSC1, TSC2
8response to ethanolGO:04547110.3ACTC1, TH, NTRK1, GRIN1
9response to nutrient levelsGO:03166710.2TH, NTRK1
10dopamine biosynthetic processGO:04241610.2SNCA, TH
11negative regulation of neuron apoptotic processGO:04352410.2BCL2L1, NTRK1, GRIN1, SNCA
12response to drugGO:0424939.9APOD, SNCA, NTRK1, ACTC1
13agingGO:0075689.8NTRK1, SNCA, APOD

Molecular functions related to Ganglioglioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ferrous iron bindingGO:00819810.2TH, SNCA
2tau protein bindingGO:04815610.0SNCA, S100B
3calcium ion bindingGO:0055099.7GRIN1, PVALB, CALB2, S100B, SNCA, SYP

Products for genes affiliated with Ganglioglioma

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Sources for Ganglioglioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet