Ganglioglioma malady

NIH Rare Diseases: A ganglioglioma is a rare type of brain tumor, accounting for approximately 1% of all brain tumors.  Gangliogliomas occur when a single cell in the brain starts to divide into more cells, forming a tumor.  This can occur when the cell randomly acquires changes (mutations) in genes that regulate how a cell divides.  Most gangliogliomas grow slowly and are considered benign.  However, up to 10% of gangliogliomas may grow more rapidly and become malignant, meaning the tumor affects the surrounding brain tissue.    The main treatment for ganglioglioma is removal of the entire tumor during surgery.  If the entire tumor is not removed, it has the potential to recur and may require additional surgery or treatments, such as radiation therapy or chemotherapy.  Unfortunately, because gangliogliomas are quite rare, there is limited information to show that radiation therapy or chemotherapy are effective treatments for this condition.³⁰

MalaCards: Ganglioglioma, also known as childhood ganglioglioma, is related to anaplastic ganglioglioma and desmoplastic infantile ganglioglioma. An important gene associated with Ganglioglioma is S100B (S100 calcium binding protein B), and among its related pathways are Apoptosis and survival Role of CDK5 in neuronal death and survival and Cytoskeleton remodeling Neurofilaments. The compounds s 100 and hematoxylin have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and cerebellum, and related mouse phenotypes are reproductive system and no phenotypic analysis.

Wikipedia: Ganglioglioma is a tumour that arises from ganglion cells in the central nervous system.⁴⁴ more...

Aliases & Descriptions:

ganglioglioma 6 30 8 32 43 childhood ganglioglioma 6 43 adult ganglioglioma 6 43

mixed cell tumors containing both neural ganglionic cells and neural glial cell components 30 ganglioglioma, no icd-o subtype 6

Diseases related to ganglioglioma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 356)

id	Related Disease	Score	Top Affiliating Genes
1	anaplastic ganglioglioma	33.5	S100B, ACTC1, GFAP, NES
2	desmoplastic infantile ganglioglioma	31.9	MYCN, CP
3	gangliocytoma	30.0	TH, PVALB, SYP
4	peripheral neuroblastoma	28.7	CHGA, S100B, SYP
5	neurofibromatosis	28.4	S100B, ENO2, TSC1, TSC2
6	rhabdoid tumors	28.3	SMARCB1, ACTC1, SYP
7	neurofibroma	27.6	S100B, APOD, CALB2, ACTC1, SYP, NES
8	atypical teratoid rhabdoid tumor	27.0	TP53, SMARCB1, ACTC1, GFAP, SYP
9	pilocytic astrocytoma	27.0	S100B, APOD, TP53, GFAP, TSC1, SYP
10	ganglioneuroblastoma	26.7	MYCN, CHGA, S100B, ENO2, TP53, NTRK1
11	dysembryoplastic neuroepithelial tumor	26.2	BCL2L1, CHGA, MVP, S100B, GRIN1, MAP2
12	astrocytoma	21.2	BIRC5, BCL2L1, MVP, S100B, CDK5, CDK5R1
13	neuroblastoma	19.6	RELN, MYCN, BIRC5, BCL2L1, CHGA, MVP
14	neuronitis	17.3	RELN, MYCN, BIRC5, BCL2L1, CHGA, MVP
15	papillary ependymoma	13.8	S100B, GFAP, SYP
16	myxopapillary ependymoma	13.8	S100B, GFAP
17	gliofibroma	13.8	S100B, GFAP
18	choroid plexus papilloma	13.8	S100B, GFAP, SYP
19	cerebral neuroblastoma	13.8	ENO2, GFAP
20	chordoid glioma	13.7	S100B, GFAP, SYP
21	pineal gland cancer	13.7	ENO2, GFAP, SYP
22	tuberous sclerosis	13.7	TSC1, TSC2
23	gastric small cell carcinoma	13.7	CHGA, ENO2, SYP
24	supratentorial neoplasm	13.7	CHGA, ENO2, SYP
25	binswanger's disease	13.7	GFAP, SYP
26	malignant giant cell tumor of soft parts	13.7	S100B, ACTC1
27	askin's tumor	13.7	S100B, ENO2, NTRK1
28	dentatorubral-pallidoluysian atrophy	13.7	CALB2, GFAP, PVALB
29	ewing's family of tumors	13.7	MYCN, CHGA, GFAP, SYP
30	glomus tumor	13.7	S100B, ACTC1, SYP
31	subependymoma	13.7	TSC2, NES
32	subependymal giant cell astrocytoma	13.7	S100B, TSC1, TSC2, SYP
33	fetal alcohol syndrome	13.7	CALB2, GFAP, PVALB
34	malignant mixed mullerian tumor	13.7	S100B, ENO2, ACTC1
35	somatostatinoma	13.7	CHGA, ENO2, ACTC1
36	central neurocytoma	13.7	MAP2, GFAP, SYP, NES
37	ossifying fibroma	13.7	CALB2, ACTC1, TSC1
38	middle ear cancer	13.7	CHGA, ENO2
39	malignant peripheral nerve sheath tumor	13.6	S100B, APOD, CALB2, NES
40	horseshoe kidney	13.6	CALB2, ACTC1, TSC2, SYP
41	lymphangioleiomyomatosis	13.6	TSC1, TSC2
42	pancreatic islet cell tumors	13.6	CHGA, TSC1, TSC2
43	cerebral hemorrhage	13.6	S100B, ENO2, GFAP, SYP
44	pulmonary sclerosing hemangioma	13.6	CHGA, ENO2, ACTC1, SYP
45	alveolar rhabdomyosarcoma	13.6	MYCN, ENO2, TH
46	esthesioneuroblastoma	13.6	S100B, ENO2, NTRK1, SYP
47	ovarian sex cord tumors	13.6	ENO2, CALB2, ACTC1, SYP
48	tubular adenocarcinoma	13.6	CHGA, ENO2, ACTC1, SYP
49	olfactory neuroblastoma	13.6	S100B, NTRK1, NTRK2
50	pineocytoma	13.6	CHGA, S100B, ENO2, GFAP, SYP

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to ganglioglioma:

²²

MGI Mouse Phenotypes related to ganglioglioma:

²⁵ (show all 12)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	reproductive system phenotype	MP:0005389	8.1	PSMC4, DCX, TSC1, SMARCB1, SNCA, DAB1
2	no phenotypic analysis	MP:0003012	8.0	NSD1, DCX, SYP, SNCA, NTRK1, DAB1
3	cardiovascular system phenotype	MP:0005385	7.6	GFAP, TSC1, TSC2, TH, CP, ACTC1
4	vision/eye phenotype	MP:0005391	7.4	SMARCB1, GFAP, TH, SLC1A1, CP, NTRK2
5	integument phenotype	MP:0010771	7.3	NTRK1, SNCA, TSC1, TSC2, TH, TP53
6	normal phenotype	MP:0002873	6.8	NTRK2, GFAP, TSC2, TH, PVALB, SYP
7	homeostasis/metabolism phenotype	MP:0005376	6.5	ACTC1, GFAP, TSC1, TSC2, TH, SLC1A1
8	nervous system phenotype	MP:0003631	5.8	NES, DAB1, CALB2, CALB1, MAP2, APOD
9	cellular phenotype	MP:0005384	5.7	ACTC1, GFAP, TSC1, TSC2, PVALB, SLC1A1
10	mortality/aging	MP:0010768	5.3	SMARCB1, GFAP, TSC1, TSC2, TH, DCX
11	growth/size phenotype	MP:0005378	5.3	TSC1, GFAP, ACTC1, SMARCB1, TSC2, TH
12	behavior/neurological phenotype	MP:0005386	5.1	CP, SLITRK1, CALB1, MAP2, ENO2, APOD

Articles related to ganglioglioma:

(show all 28)

id	Title	Authors	Year	Affiliating Genes
1	Anaplastic ganglioglioma with malignant features in b oth neuronal and glial components--case report. (20339274)	Kawataki T.... Kinouchi H.	2010	NES
2	Inhibitory networks in epilepsy-associated gangliogliomas and in the perilesional epileptic cortex. (17267178)	Aronica E.... Troost D.	2007	CALB1, CALB2, SLC6A1
3	Desmoplastic infantile ganglioglioma: novel aspects in clinical presentation and genetics. (17719974)	LAPnnrot K.... HelAcn P.	2007	MYCN
4	Differential cellular gene expression in ganglioglioma. (17437409)	Samadani U.... Crino P.B.	2007	HGF, GRM5, GRM3
5	Survivin expression in ganglioglioma. (16292482)	Rousseau A.... Hauw J.J.	2006	BIRC5
6	Atypical teratoid/rhabdoid tumor evolving from an optic pathway ganglioglioma: case study. (16443951)	Allen J.C.... Biegel J.A.	2006	SMARCB1
7	Aberrant TP53 protein accumulation in the neuronal component of ganglioglioma. (15925988)	Fukushima T.... Yokoyama T.	2005	TP53
8	Case of desmoplastic infantile ganglioglioma secreting ceruloplasmin. (16417865)	Knapp J.... Maria B.L.	2005	CP
9	Ganglioglioma in a Sotos syndrome patient with an NSD1 deletion. (15455365)	Deardorff M.A.... Zackai E.H.	2004	NSD1
10	The reelin pathway components disabled-1 and p35 in gangliogliomas--a mutation and expression analysis. (15175076)	Kam R.... Becker A.J.	2004	CDK5R1, RELN, DAB1
11	Overexpression of the human major vault protein in gangliogliomas. (12919388)	Aronica E.... Troost D.	2003	MVP
12	Anaplastic ganglioglioma with sarcomatous component: an immunohistochemical study and molecular analysis of p53 tumor suppressor gene. (12030414)	Suzuki H.... Takei H.	2002	ACTC1
13	Mutational and expression analysis of the reelin pathway components CDK5 and doublecortin in gangliogliomas. (12200628)	Becker A.J.... Blumcke I.	2002	CDK5, DCX, RELN
14	Mutational analysis of TSC1 and TSC2 genes in gangliogliomas. (11437991)	Becker A.J.... Blumcke I.	2001	TSC1, TSC2
15	Tuberin expression in ganglioglioma. (10808554)	Arai Y.... Becker L.E.	2000	TSC2
16	Synaptophysin staining for ganglioglioma. (10219424)	Quinn B.	1999	SYP
17	Clinicopathological analysis of pilocytic astrocytomas and gangliogliomas in children. (10581849)	Fiks T.... Liberski P.P.	1999	GFAP
18	Bcl-2 and Bcl-X expression in gangliogliomas. (10374780)	Prayson R.A.	1999	BCL2L1
19	The significance of immunocytochemical markers, synaptophysin and neurofilaments in diagnosis of ganglioglioma. (10581850)	Wierzba-Bobrowicz T.... Bertrand E.	1999	SYP
20	Synaptophysin staining in normal brain: importance for diagnosis of ganglioglioma. (9591724)	Quinn B.	1998	SYP
21	Mixed dysembryoplastic neuroepithelial tumor and ganglioglioma. (9650758)	Hirose T.... Scheithauer B.W.	1998	SYP, CHGA
22	Rapid growth of an optic nerve ganglioglioma in a patient with neurofibromatosis 1. (8637690)	Sadun F.... Sadun A.A.	1996	ENO2, SYP
23	Ganglioglioma of the brain stem: neurological dysfunction of 16-year duration. (7671459)	Karamitopoulou E.... Wegmann W.	1995	TUBB
24	An immunohistochemical study of peripheral neuroblastoma, ganglioneuroblastoma, anaplastic ganglioglioma, schwannoma and neurofibroma in cattle. (7962722)	Omi K.... Kadota K.	1994	S100B
25	Malignant transformation in a ganglioglioma with anaplastic neuronal and astrocytic components. Report of a case with flow cytometric and cytogenetic analysis. (8194028)	Jay V.... Humphreys R.	1994	GFAP, SYP
26	Parvalbumin and calbindin D-28K immunoreactivity in c entral ganglioglioma and dysplastic gangliocytoma of the cerebellum. Report of two cases. (8416231)	Ferrer I.... ZA_jar M.J.	1993	PVALB
27	Central nervous system gangliogliomas. Part 1: Pathology. (8246054)	Miller D.C.... Epstein F.J.	1993	SYP
28	A clinicopathologic and immunomorphologic study of 13 cases of ganglioglioma. (1913457)	Diepholder H.M.... Volk B.	1991	TH, SYP, CHGA

Genes related to ganglioglioma according to GeneCards:

(show all 44)

id	Symbol	Description	Score	GeneCards Section Context
1	S100B	S100 calcium binding protein B	11.0	Publications
2	GFAP	glial fibrillary acidic protein	11.0	Publications
3	SYP	synaptophysin	11.0	Publications
4	NES	nestin	11.0	Publications
5	MYCN	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	11.0	Publications
6	PVALB	parvalbumin	11.0	Publications
7	DCX	doublecortin	11.0	Publications
8	ACTC1	actin, alpha, cardiac muscle 1	11.0	Publications
9	APOD	apolipoprotein D	11.0
10	TSC1	tuberous sclerosis 1	11.0	Publications
11	CALB2	calbindin 2	11.0	Publications
12	TSC2	tuberous sclerosis 2	11.0	Publications
13	CHGA	chromogranin A (parathyroid secretory protein 1)	11.0	Publications
14	TUBB	tubulin, beta class I	11.0	Publications
15	TH	tyrosine hydroxylase	11.0	Publications
16	ENO2	enolase 2 (gamma, neuronal)	11.0	Publications
17	NTRK1	neurotrophic tyrosine kinase, receptor, type 1	11.0
18	CP	ceruloplasmin (ferroxidase)	11.0	Publications
19	GRIN1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	11.0
20	RELN	reelin	11.0	Publications
21	MAP2	microtubule-associated protein 2	11.0
22	BCL2L1	BCL2-like 1	11.0	Publications
23	NTRK2	neurotrophic tyrosine kinase, receptor, type 2	11.0
24	SNCA	synuclein, alpha (non A4 component of amyloid precursor)	11.0
25	SLITRK3	SLIT and NTRK-like family, member 3	11.0	Expressions
26	SLITRK1	SLIT and NTRK-like family, member 1	11.0	Expressions
27	SLITRK2	SLIT and NTRK-like family, member 2	11.0	Expressions
28	SLC6A1	solute carrier family 6 (neurotransmitter transporter, GABA), member 1	11.0	Publications
29	CDK5R1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	11.0	Publications
30	CALB1	calbindin 1, 28kDa	11.0	Publications
31	NSD1	nuclear receptor binding SET domain protein 1	11.0	Publications
32	MVP	major vault protein	11.0	Publications
33	SLC1A1	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	11.0	Publications
34	CDK5	cyclin-dependent kinase 5	11.0	Publications
35	PSMC4	proteasome (prosome, macropain) 26S subunit, ATPase, 4	11.0	Publications
36	SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	11.0	Publications
37	GRM3	glutamate receptor, metabotropic 3	11.0	Publications
38	BIRC5	baculoviral IAP repeat containing 5	11.0	Publications
39	GRM5	glutamate receptor, metabotropic 5	11.0	Publications
40	HGF	hepatocyte growth factor (hepapoietin A; scatter factor)	11.0	Publications
41	LDB2	LIM domain binding 2	11.0
42	DAB1	disabled homolog 1 (Drosophila)	11.0	Publications
43	TP53	tumor protein p53	11.0	Publications
44	GLS	glutaminase	-9.3	Expressions

Pathways related to ganglioglioma according to GeneDecks:

(show all 16)

id	Pathway	Score	Top Affiliating Genes
1	Apoptosis and survival Role of CDK5 in neuronal death and survival10	10.1	NTRK1, CDK5R1, CDK5
2	Cytoskeleton remodeling Neurofilaments10	10.0	NES, GFAP, TUBB, CDK5R1, CDK5
3	Cytoskeleton remodeling_Neurofilaments41	9.9	NES, GFAP, TUBB, CDK5R1, CDK5
4	Alzheimers Disease Pathway36	9.9	CDK5, CDK5R1, NTRK1, NTRK2
5	14-3-3 Induced Intracellular Signaling36	9.8	TSC2, TSC1, SNCA, NTRK2, NTRK1
6	Glutamic acid signaling10	9.5	GRIN1, GRM3, GRM5, SLC1A1
7	Signal transduction_AKT signaling41	9.4	BCL2L1, TP53, TSC1, TSC2
8	Pathogenesis of ALS36	9.3	BCL2L1, GRIN1, TP53, SLC1A1
9	Guidance Cues and Growth Cone Motility36	9.3	NTRK2, NTRK1, DAB1, CDK5, RELN
10	Apoptosis and survival_Role of CDK5 in neuronal death and survival41	9.3	NTRK1, TP53, CDK5R1, CDK5
11	Reelin Pathway (Cajal-Retzius cells)36	9.2	RELN, CDK5, CDK5R1, DAB1
12	Glutamatergic synapse20	8.9	SLC1A1, GLS, GRM5, GRM3, GRIN1
13	JNK Pathway36	8.9	NTRK2, NTRK1, TP53, MAP2
14	Mitochondrial Apoptosis36	8.6	HGF, NTRK2, NTRK1, TP53, BCL2L1
15	Pancreatic Adenocarcinoma36	8.3	HGF, NTRK2, NTRK1, TP53, BCL2L1, BIRC5
16	Neuroscience3	7.8	MYCN, DCX, SYP, TH, GFAP, SNCA

Compounds related to ganglioglioma according to GeneDecks:

(show top 50)    (show all 151)

id	Compound	Score	Top Affiliating Genes
1	s 10032	10.2	SYP, CHGA, S100B, ENO2, ACTC1, GFAP
2	hematoxylin32	9.9	S100B, ENO2, SYP, MAP2, CHGA, GFAP
3	l-amino acid32	9.9	MAP2, S100B, SYP, CHGA, CALB1, ENO2
4	catecholamine32	9.7	SYP, SNCA, NTRK1, MYCN, CHGA, S100B
5	h2o232	9.7	CDK5, SYP, TUBB, TH, SNCA, NTRK2
6	silver32	9.6	PVALB, CALB2, GFAP, SNCA, SYP, CALB1
7	formaldehyde32 18	10.6	GFAP, CHGA, PVALB, S100B, ENO2, CALB1
8	quinolinic acid32 18	10.5	NTRK2, GLS, CALB2, CALB1, GFAP, PVALB
9	acetylcholine32 9 18 9	12.3	SNCA, CALB1, S100B, CHGA, CALB2, NTRK1
10	threonine32	9.2	CDK5, CDK5R1, NTRK1, GRM5, MAP2, TUBB
11	bromodeoxyuridine32	9.2	GFAP, CHGA, MYCN, ENO2, MAP2, NES
12	cocaine32 9 9	10.9	CDK5, GRIN1, GFAP, SNCA, TH, MAP2
13	choline32 9 18 9	11.8	SYP, NES, PVALB, TH, GFAP, SNCA
14	alanine32	8.8	SLC1A1, BIRC5, PSMC4, GFAP, S100B, NTRK1
15	dutp32	8.8	BIRC5, GFAP, NTRK1, TP53, BCL2L1, SYP
16	ethanol32 34 9 18 9	12.6	SNCA, S100B, GRM5, CALB2, NTRK2, GRIN1
17	kainate32	8.6	CALB1, MAP2, GRM5, GRM3, GRIN1, PVALB
18	adenylate32	8.5	GFAP, TH, TSC2, CP, SNCA, CHGA
19	vinblastine32 9 9	10.4	NTRK2, TP53, TUBB, MAP2, MVP, BIRC5
20	norepinephrine32 9 18 9	11.3	SLC6A1, TH, HGF, NTRK2, SNCA, MAP2
21	glycogen32 18	9.3	RELN, S100B, CDK5, CDK5R1, ENO2, MAP2
22	aspartate32	8.3	HGF, SLC1A1, PVALB, TH, GLS, NTRK2
23	lactate32	8.2	GLS, GFAP, NTRK1, ENO2, MYCN, TH
24	glutamine32	8.1	GRIN1, CDK5, ENO2, S100B, GLS, TUBB
25	potassium32 9 18 9	11.1	HGF, SLC1A1, PSMC4, CALB1, GLS, S100B
26	progesterone32 42 9 18 9	12.1	NTRK1, CALB2, BIRC5, ACTC1, NES, SYP
27	glucose32	8.0	SLC1A1, SLC6A1, NES, TSC2, PSMC4, S100B
28	etoposide32 42 9 9	10.9	CHGA, MVP, S100B, ENO2, HGF, PSMC4
29	cisplatin32 34 9 9	10.8	MYCN, BIRC5, CHGA, HGF, SYP, GFAP
30	testosterone32 9 18 9	10.8	APOD, NTRK1, NTRK2, SNCA, ACTC1, GFAP
31	cysteine32	7.8	GLS, GFAP, TH, SYP, PSMC4, SLC1A1
32	paclitaxel32 34 9 9	10.8	BCL2L1, CHGA, MVP, S100B, CDK5, BIRC5
33	dopamine32 9 18 9	10.8	CALB1, CALB2, NTRK1, NTRK2, SNCA, GFAP
34	phosphatidylinositol32	7.7	RELN, BIRC5, BCL2L1, CDK5, GRIN1, TSC2
35	nitric oxide32 9 18 9	10.6	S100B, SLC6A1, NES, PSMC4, SYP, PVALB
36	dexamethasone32 42 34 9 9	11.5	GLS, CALB1, HGF, ENO2, S100B, CHGA
37	atp32	7.3	NTRK1, GFAP, TUBB, GLS, CALB1, MAP2
38	phosphoinositide32	7.3	NTRK1, NTRK2, TSC1, PSMC4, HGF, DAB1
39	oxygen32 18	8.3	GFAP, TSC2, TH, PSMC4, CP, HGF
40	lipid32	7.3	RELN, BIRC5, PSMC4, TUBB, NTRK1, NTRK2
41	gaba32 42	8.2	GRM3, GRIN1, S100B, CHGA, RELN, GLS
42	paraffin32	6.7	MYCN, BIRC5, BCL2L1, CHGA, MVP, S100B
43	vegf32	6.6	MYCN, TSC2, TH, SYP, DCX, PSMC4
44	estrogen32	6.5	GFAP, ACTC1, NTRK2, TSC2, TH, PVALB
45	retinoic acid32 42 18	8.2	CALB1, TP53, NTRK1, NTRK2, ACTC1, GFAP
46	nmda32 42	7.2	RELN, TH, PVALB, SYP, SLC1A1, CP
47	glutamate32	6.1	NTRK1, SNCA, GFAP, TH, PVALB, SLC1A1
48	calcium32 9 18 9	8.3	DAB1, NTRK1, NTRK2, SNCA, ACTC1, PVALB
49	tyrosine32	5.3	TUBB, NES, HGF, PSMC4, SYP, SNCA
50	serine32	5.1	BCL2L1, GRM5, MAP2, GLS, TUBB, TP53

Cellular components related to ganglioglioma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	TSC1-TSC2 complex	GO:033596	10.2	TSC1, TSC2
2	cyclin-dependent protein kinase 5 holoenzyme complex	GO:016533	9.7	CDK5, CDK5R1
3	growth cone	GO:030426	9.6	TSC1, SNCA, NTRK2, CDK5R1, CDK5
4	dendrite	GO:030425	9.4	DCX, CALB1, APOD, GRIN1, CDK5R1, CDK5
5	neuronal cell body	GO:043025	9.3	NTRK2, CALB1, MAP2, APOD, CDK5R1, CDK5
6	postsynaptic density	GO:014069	9.3	NTRK2, GRM3, GRIN1, CDK5R1, CDK5
7	axon	GO:030424	9.1	CDK5, SLC6A1, PVALB, SNCA, CALB1, GRM3
8	cytoplasm	GO:005737	6.5	ACTC1, GFAP, TSC1, TSC2, TH, PVALB
9	cytosol	GO:005829	6.4	SNCA, ACTC1, GFAP, TSC1, TSC2, TH

Biological processes related to ganglioglioma according to GeneDecks:

(show all 19)

id	Name	GO ID	Score	Top Affiliating Genes
1	long-term synaptic potentiation	GO:060291	10.3	GFAP, SNCA, NTRK2
2	cellular response to organic substance	GO:071310	10.2	SYP, CALB1, MAP2
3	regulation of long-term neuronal synaptic plasticity	GO:048169	10.2	SYP, SNCA, GRIN1
4	central nervous system neuron development	GO:021954	10.1	NTRK2, MAP2, CDK5
5	dendrite morphogenesis	GO:048813	10.1	DCX, MAP2, CDK5
6	regulation of excitatory postsynaptic membrane potential	GO:060079	10.1	SNCA, GRIN1, CDK5
7	brain development	GO:007420	10.1	NES, DCX, APOD, CDK5R1, RELN
8	hippocampus development	GO:021766	10.0	TSC1, CDK5R1, CDK5, RELN
9	negative regulation of neuron apoptotic process	GO:043524	10.0	BCL2L1, GRIN1, NTRK1, NTRK2, SNCA
10	serine phosphorylation of STAT3 protein	GO:033136	10.0	CDK5R1, CDK5
11	positive regulation of protein targeting to membrane	GO:090314	10.0	CDK5, CDK5R1
12	axonogenesis	GO:007409	10.0	SLITRK1, SLITRK3, SLITRK2, MAP2, S100B
13	response to drug	GO:042493	9.8	NES, ACTC1, SNCA, ENO2, APOD, MVP
14	neuron differentiation	GO:030182	9.7	CDK5, CDK5R1, TUBB, NTRK2
15	peptidyl-threonine phosphorylation	GO:018107	9.7	CDK5, CDK5R1, MAP2
16	learning	GO:007612	9.7	NTRK2, TH, SLC6A1
17	central nervous system development	GO:007417	9.5	NES, DCX, TP53, S100B, RELN
18	neuron migration	GO:001764	9.2	RELN, CDK5, CDK5R1, DAB1, NTRK2, DCX
19	synaptic transmission	GO:007268	8.5	SLC6A1, SLC1A1, GLS, GRM5, GRM3, GRIN1

Molecular functions related to ganglioglioma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	neurotrophin binding	GO:043121	10.1	NTRK2, NTRK1
2	chaperone binding	GO:051087	9.0	BIRC5, TP53, TSC1, CP
3	calcium ion binding	GO:005509	9.0	SYP, PVALB, SNCA, CALB2, CALB1, GRIN1
4	identical protein binding	GO:042802	8.8	SNCA, TP53, S100B, BCL2L1, BIRC5, SYP