MCID: GNG004
MIFTS: 54

Ganglioglioma malady

Neuronal, Cancer categories

Summaries for Ganglioglioma

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 A ganglioglioma is a rare type of brain tumor, accounting for approximately 1% of all brain tumors.  gangliogliomas occur when a single cell in the brain starts to divide into more cells, forming a tumor.  this can occur when the cell randomly acquires changes (mutations) in genes that regulate how a cell divides.  most gangliogliomas grow slowly and are considered benign.  however, up to 10% of gangliogliomas may grow more rapidly and become malignant, meaning the tumor affects the surrounding brain tissue.    the main treatment for ganglioglioma is removal of the entire tumor during surgery.  if the entire tumor is not removed, it has the potential to recur and may require additional surgery or treatments, such as radiation therapy or chemotherapy.  unfortunately, because gangliogliomas are quite rare, there is limited information to show that radiation therapy or chemotherapy are effective treatments for this condition. last updated: 7/11/2011

MalaCards: Ganglioglioma, also known as childhood ganglioglioma, is related to gangliocytoma and neurofibromatosis. An important gene associated with Ganglioglioma is S100B (S100 calcium binding protein B), and among its related pathways are Inhibition of TSC complex formation by PKB and Development IGF-RI signaling. The compounds estrogen and glutamate have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and cortex, and related mouse phenotypes are integument and no phenotypic analysis.

Wikipedia:64 Ganglioglioma is a tumour that arises from ganglion cells in the central nervous system. Gangliogliomas... more...

Aliases & Classifications for Ganglioglioma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 35MeSH, 57SNOMED-CT, 40NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Neuronal


Aliases & Descriptions:

ganglioglioma 8 43 10 45 49 61
childhood ganglioglioma 8 61
adult ganglioglioma 8 61
mixed cell tumors containing both neural ganglionic cells and neural glial cell components 43
ganglioglioma, no icd-o subtype 8


External Ids:

Disease Ontology8 DOID:5078
MeSH35 D018303
SNOMED-CT57 89880005
NCIt40 C3788

Related Diseases for Ganglioglioma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Ganglioglioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 203)
idRelated DiseaseScoreTop Affiliating Genes
1gangliocytoma30.4SYP
2neurofibromatosis30.4TSC2, TSC1, ENO2, S100B
3astrocytoma30.4TSC2, TSC1, GFAP, NTRK1, SYP, NES
4dysembryoplastic neuroepithelial tumor30.3SYP
5rhabdoid tumor30.2ACTC1, SYP
6temporal lobe epilepsy30.2GFAP, GRIN1, PVALB
7pilocytic astrocytoma30.1TSC1, GFAP, SYP, DCX, NES, APOD
8tuberous sclerosis30.1TSC2, TSC1, GFAP, SYP, DCX, NES
9gliosarcoma29.9GFAP
10giant cell glioblastoma29.8GFAP
11status epilepticus29.8ENO2, DCX
12anaplastic ependymoma29.8GFAP, S100B
13ependymoma29.8TSC2, ENO2, GFAP, SYP, DCX, NES
14alzheimer's disease29.8CP, TSC2, TSC1, TH, GFAP, NTRK1
15desmoplastic infantile ganglioglioma10.8
16anaplastic ganglioglioma10.7
17pleomorphic xanthoastrocytoma10.4
18desmoplastic infantile astrocytoma/ganglioglioma10.3
19desmoplastic infantile astrocytoma10.2
20nasal ganglioglioma10.2
21atypical teratoid rhabdoid tumor10.2
22n syndrome10.1
23retinitis10.0DCX
24focal epilepsy10.0DCX
25phaeochromocytoma10.0CHGA
26pneumothorax10.0TSC1
27hemangioma10.0ACTC1
28medulloepithelioma10.0SYP
29perivascular epithelioid cell tumor10.0TSC2
30encephalitis10.0GFAP
31melanotic neuroectodermal tumor10.0SYP
32somatostatinoma10.0CHGA
33fetal alcohol spectrum disorder10.0PVALB
34sertoli-leydig cell tumor10.0CALB2
35dermatofibrosarcoma protuberans10.0ACTC1, S100B
36kidney rhabdoid cancer10.0TSC2
37scrapie10.0PVALB
38pancreatic islet cell tumors10.0CHGA, SYP
39hepatitis10.0CP, MYCN
40subependymoma10.0TSC2
41down syndrome10.0SNCA, S100B
42dysautonomia10.0SNCA
43multiple sclerosis10.0BCL2L1, GFAP
44myxopapillary ependymoma10.0GFAP, S100B
45papilloma10.0ACTC1, MYCN
46glomus tumor10.0ACTC1, SYP
47cerebral primitive neuroectodermal tumor10.0MYCN
48spinocerebellar ataxia type 310.0SNCA
49papillary ependymoma10.0GFAP, SYP, S100B
50malignant mesothelioma10.0BCL2L1, CALB2

Graphical network of the top 20 diseases related to Ganglioglioma:



Diseases related to ganglioglioma

Clinical Features for Ganglioglioma

Drugs & Therapeutics for Ganglioglioma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Ganglioglioma

Drug clinical trials:

Search ClinicalTrials for Ganglioglioma

Search NIH Clinical Center for Ganglioglioma

Search CenterWatch for Ganglioglioma

Genetic Tests for Ganglioglioma

Anatomical Context for Ganglioglioma

Sources:
33MalaCards
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MalaCards organs/tissues related to Ganglioglioma:

33
Spinal cord, Brain, Cortex, Cerebellum, Parietal lobe, Temporal lobe, Occipital lobe, Thalamus, Medulla oblongata, Trigeminal ganglion, Pineal

Animal Models for Ganglioglioma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Ganglioglioma

Sources:
51PubMed
See all sources

Articles related to Ganglioglioma:

(show top 50)    (show all 375)
idTitleAuthorsYear
1
Ganglioglioma of the spinal cord in neurofibromatosis type 1. (24192615)
2013
2
Intramedullary spinal cord ganglioglioma presenting as hyperhidrosis: unique symptoms and magnetic resonance imaging findings: case report. (23198806)
2013
3
Malignant progression of anaplastic supratentorial ganglioglioma into glioblastoma multiforme in a patient with turner syndrome. (21170828)
2012
4
Isocitrate dehydrogenase 1 analysis differentiates gangliogliomas from infiltrative gliomas. (21314850)
2011
5
Desmoplastic non-infantile ganglioglioma in late adulthood. (20857318)
2011
6
A multinodular ganglioglioma with ependymal differentiation. (21726508)
2011
7
Desmoplastic ganglioglioma of the spinal cord in a western European hedgehog (Erinaceus europaeus). (21088188)
2010
8
Ganglioglioma in the cerebellopontine angle of an adult without seizures. (19772036)
2009
9
Anaplastic ganglioglioma in children. (19043777)
2009
10
Desmoplastic infantile ganglioglioma with a malignant course. (18352812)
2008
11
Desmoplastic ganglioglioma with meningiomatous and myofibroblastic components presenting with epilepsy. (17961139)
2008
12
Desmoplastic infantile ganglioglioma: a report of 2 cases and a review of the literature. (18703892)
2008
13
Suprasellar ganglioglioma with unusual diffuse involvement of the entire optico-chiasmal hypothalamic pathway. (18923209)
2008
14
Ganglioglioma in the cerebellopontine angle in a child. Case report and review of the literature. (17941493)
2007
15
Spinal cord ganglioglioma presenting as acute paraparesis. (15946791)
2006
16
Ganglioglioma of conus medullaris. (16855813)
2006
17
Survivin expression in ganglioglioma. (16292482)
2006
18
Desmoplastic noninfantile ganglioglioma: report of a case. (17163789)
2006
19
Desmoplastic non-infantile ganglioglioma. (15875908)
2005
20
Case of desmoplastic infantile ganglioglioma secreting ceruloplasmin. (16417865)
2005
21
Abnormal behavior in children with temporal lobe epilepsy and ganglioglioma. (15380137)
2004
22
Pathologic quiz case: a 4-year-old boy with headache, seizures, and brain mass. Ganglioglioma. (12951988)
2003
23
Desmoplastic infantile ganglioglioma. (12750935)
2003
24
Congenital ganglioglioma. (12003306)
2002
25
Anaplastic ganglioglioma with sarcomatous component: an immunohistochemical study and molecular analysis of p53 tumor suppressor gene. (12030414)
2002
26
Ganglioglioma presenting as a meningioma: case report and review of the literature. (11950418)
2002
27
Mutational and expression analysis of the reelin pathway components CDK5 and doublecortin in gangliogliomas. (12200628)
2002
28
Intraventricular trigonal ganglioglioma arising from the choroid plexus. (11685629)
2001
29
Generalized tonic seizures associated with ganglioglioma: successful treatment with surgical resection. (11721134)
2001
30
Image interpretation session: 1999. Desmoplastic infantile ganglioglioma. (10682792)
2000
31
Respiratory control and respiratory sensation in a patient with a ganglioglioma within the dorsocaudal brain stem. (10852794)
2000
32
Desmoplastic non-infantile ganglioglioma. Case report. (11126451)
2000
33
Ultrastructural identification of protein bodies, cellular markers of human catecholamine neurons, in a temporal lobe ganglioglioma. (11206337)
2000
34
Ganglioglioma of the optic chiasm: case report and review of the literature. (11003284)
2000
35
Malignant supratentorial ganglioglioma (ganglion cell-giant cell glioblastoma): a case report and review of the literature. (10320149)
1999
36
Angiomatous pleomorphic xanthoastrocytoma as a component of ganglioglioma. (17337987)
1999
37
Recurrent anaplastic ganglioglioma: pathological characterization of tumor cells. Case report. (8847572)
1996
38
Chromosomal alterations in a case of ganglioglioma. (8548741)
1995
39
Anaplastic temporal lobe ganglioglioma. Case report. (1340924)
1992
40
Ganglioglioma in children. A review of 32 cases at the University of Florida. (1476942)
1992
41
Differentiation of a primitive neuroectodermal tumor into a benign ganglioglioma. (1460486)
1992
42
Hemifacial spasm in an infant due to fourth ventricular ganglioglioma. Case report. (2045898)
1991
43
Intracranial ganglioglioma: MR, CT, and clinical findings in 18 patients. (2105590)
1990
44
Fine needle aspiration cytology of a cerebral ganglioglioma. Report of a case. (3287820)
1988
45
Ultrasound, computed tomography and magnetic resonance of a neonatal ganglioglioma of the brain. (3534777)
1986
46
A human ganglioglioma containing paired helical filaments. (6469236)
1984
47
Ganglioglioma of the brain stem. Case report. (6693970)
1984
48
Cerebellar ganglioglioma in a child. (219154)
1979
49
A light- and electron-microscopic study of a temporal-lobe ganglioglioma. (5034853)
1972
50
Gangliogliomatous differentiation in a pineocytoma. (4101025)
1970

Genetic Variations for Ganglioglioma

Expression for genes affiliated with Ganglioglioma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Ganglioglioma

Search GEO for disease gene expression data for Ganglioglioma.

Pathways for genes affiliated with Ganglioglioma

Sources:
54Reactome, 12EMD Millipore, 53R&D Systems, 4Cell Signaling Technology
See all sources

Compounds for genes affiliated with Ganglioglioma

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 29IUPHAR, 11DrugBank, 60Tocris Bioscience
See all sources

Compounds related to Ganglioglioma according to GeneCards/GeneDecks:

(show top 50)    (show all 110)
idCompoundScoreTop Affiliating Genes
1estrogen4510.6PVALB, CALB2, GFAP
2glutamate4510.5GRIN1, GFAP, SNCA, NTRK1
3reticulin4510.4ACTC1, S100B, GFAP, SYP
4vanillylmandelic acid45 2411.4MYCN, ENO2, TH, CHGA
5s 1004510.4ENO2, ACTC1, CHGA, SYP, S100B, GFAP
6b 7234510.3CALB2, ACTC1, S100B, CHGA, SYP
7homovanillic acid45 2411.3TH, GFAP, MYCN, ENO2, CHGA
8l-amino acid4510.3S100B, ENO2, TH, SYP, CHGA
9mucicarmine4510.3ACTC1, CALB2, S100B, SYP
10glucose4510.3TSC2, SNCA, GFAP, ACTC1, TSC1
11dexamethasone45 50 29 1113.2GFAP, TH, ENO2, BCL2L1, S100B
12hematoxylin4510.2ACTC1, ENO2, S100B, GFAP, CHGA, SYP
13glycogen45 2411.2TSC2, GFAP, CHGA, TSC1, ACTC1, SNCA
14mptp4510.2SNCA, GRIN1, GFAP, TH, BCL2L1
15kainate45 2911.2SYP, GRIN1, GFAP, TH, DCX, PVALB
16bromodeoxyuridine4510.2GFAP, CHGA, DCX, ENO2, S100B, NES
17creatinine4510.1CP, ACTC1, GFAP, NTRK1, CHGA, SYP
18dbc-amp4510.1SYP, S100B, ENO2, MYCN, GFAP
19nmda45 2911.1TH, BCL2L1, GRIN1, SYP, CP, GFAP
20ganglioside4510.1NES, SYP, NTRK1, GFAP, ENO2
21silver4510.1SYP, SNCA, CHGA, ENO2, CALB2, GFAP
225-hydroxytryptamine4510.1ENO2, SYP, CHGA, GFAP, CALB2, TH
23formaldehyde45 2411.1GFAP, CHGA, ENO2, ACTC1, TH, SYP
24steroid4510.1SYP, ACTC1, CALB2, TSC2
25catecholamine4510.1ENO2, TH, MYCN, NTRK1, CHGA, SYP
26ethanol45 50 11 2413.0GRIN1, SNCA, PVALB, CALB2, SYP, GFAP
27glutamine4510.0SNCA, SYP, CP, ENO2, GRIN1, S100B
28lactate4510.0CHGA, NTRK1, MYCN, TH, ENO2, CP
29norepinephrine45 11 2411.9S100B, ENO2, SNCA, TH, CHGA, GRIN1
30iron45 2410.9ENO2, ACTC1, TH, MYCN, S100B, GFAP
31gaba459.9CHGA, PVALB, S100B, NES, SYP, CALB2
32smcc459.9CHGA, ENO2, SYP
33adenylate459.9ENO2, S100B, CHGA, NTRK1, GFAP, TH
34etoposide45 50 60 1112.9CHGA, SYP, S100B, BCL2L1, MYCN, ENO2
35progesterone45 60 29 11 2413.8CALB2, S100B, APOD, NES, ACTC1, SYP
36choline45 11 2411.8ENO2, PVALB, CALB2, S100B, SNCA, NES
37acetylcholine45 50 29 11 2413.8CALB2, SNCA, NES, SYP, CHGA, NTRK1
38matrigel459.8NTRK1, CHGA, GFAP, NES, BCL2L1, ACTC1
39cysteine459.7BCL2L1, S100B, CP, GFAP, NTRK1, TH
40dopamine45 29 11 2412.7MYCN, NTRK1, GRIN1, CHGA, NES, SNCA
41nitric oxide45 11 2411.7SYP, CHGA, MYCN, NES, SNCA, CALB2
42lipid459.6NTRK1, SYP, NES, CHGA, SNCA, GRIN1
43testosterone45 60 11 2412.5CP, TSC2, ENO2, ACTC1, TH, GFAP
44oxygen45 2410.5NES, BCL2L1, NTRK1, CP, CHGA, GFAP
45retinoic acid45 2410.5S100B, APOD, NES, SYP, GRIN1, MYCN
46serine459.4PVALB, S100B, SNCA, DCX, SYP, CHGA
47vegf459.4MYCN, GFAP, TH, ACTC1, ENO2, TSC2
48calcium45 50 11 2412.3SNCA, PVALB, CALB2, ENO2, CHGA, ACTC1
49tyrosine459.1CHGA, SYP, NES, SNCA, S100B, PVALB
50paraffin459.1SYP, NES, SNCA, APOD, S100B, CALB2

GO Terms for genes affiliated with Ganglioglioma

Sources:
16Gene Ontology
See all sources

Cellular components related to Ganglioglioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1TSC1-TSC2 complexGO:03359610.4TSC1, TSC2
2terminal boutonGO:04319510.3TH, GRIN1, SNCA
3synaptic vesicleGO:00802110.2TH, GRIN1, SNCA
4growth coneGO:03042610.1TSC2, TSC1, SNCA
5dendriteGO:03042510.1TSC2, TH, NTRK1, GRIN1, APOD
6neuronal cell bodyGO:0430259.8S100B, APOD, NTRK1, TSC2
7cytosolGO:0058299.5SNCA, DCX, GFAP, TH, ACTC1, ENO2
8cytoplasmGO:0057379.2PVALB, CALB2, S100B, SNCA, NES, GFAP

Biological processes related to Ganglioglioma according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1cellular response to manganese ionGO:07128710.5TH, GRIN1
2long-term synaptic potentiationGO:06029110.4S100B, SNCA, GFAP
3regulation of long-term neuronal synaptic plasticityGO:04816910.4GRIN1, SYP, SNCA
4cellular response to nicotineGO:07131610.4TH, NTRK1
5negative regulation of platelet-derived growth factor receptor signaling pathwayGO:01064210.4SNCA, APOD
6cerebral cortex developmentGO:02198710.3GRIN1, TH, TSC1
7negative regulation of cell sizeGO:04579210.3TSC1, TSC2
8response to ethanolGO:04547110.3ACTC1, TH, NTRK1, GRIN1
9response to nutrient levelsGO:03166710.2TH, NTRK1
10dopamine biosynthetic processGO:04241610.2SNCA, TH
11negative regulation of neuron apoptotic processGO:04352410.2BCL2L1, NTRK1, GRIN1, SNCA
12response to drugGO:0424939.9APOD, SNCA, NTRK1, ACTC1
13agingGO:0075689.8NTRK1, SNCA, APOD

Molecular functions related to Ganglioglioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ferrous iron bindingGO:00819810.2TH, SNCA
2tau protein bindingGO:04815610.0SNCA, S100B
3calcium ion bindingGO:0055099.7GRIN1, PVALB, CALB2, S100B, SNCA, SYP

Products for genes affiliated with Ganglioglioma

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Sources for Ganglioglioma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet