MCID: GNG004
MIFTS: 53

Ganglioglioma malady

Rare diseases, Neuronal diseases, Cancer diseases categories

Summaries for Ganglioglioma

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44NIH Rare Diseases, 66Wikipedia, 34MalaCards
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NIH Rare Diseases:44 A ganglioglioma is a rare type of brain tumor, accounting for approximately 1% of all brain tumors.  gangliogliomas occur when a single cell in the brain starts to divide into more cells, forming a tumor.  this can occur when the cell randomly acquires changes (mutations) in genes that regulate how a cell divides.  most gangliogliomas grow slowly and are considered benign.  however, up to 10% of gangliogliomas may grow more rapidly and become malignant, meaning the tumor affects the surrounding brain tissue.    the main treatment for ganglioglioma is removal of the entire tumor during surgery.  if the entire tumor is not removed, it has the potential to recur and may require additional surgery or treatments, such as radiation therapy or chemotherapy.  unfortunately, because gangliogliomas are quite rare, there is limited information to show that radiation therapy or chemotherapy are effective treatments for this condition. last updated: 7/11/2011

MalaCards: Ganglioglioma, also known as childhood ganglioglioma, is related to dysembryoplastic neuroepithelial tumor and astrocytoma. An important gene associated with Ganglioglioma is S100B (S100 calcium binding protein B), and among its related pathways are Nuclear signaling by ERBB4 and Cytoplasmic microtubules. The compounds eosin and 2,3-cyclic nucleotide have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and temporal lobe, and related mouse phenotypes are nervous system and normal.

Wikipedia:66 Ganglioglioma is a tumour that arises from ganglion cells in the central nervous system. Gangliogliomas... more...

Aliases & Classifications for Ganglioglioma

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 50Orphanet, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH, 64UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

ganglioglioma 9 44 11 46 50 63
childhood ganglioglioma 9 63
adult ganglioglioma 9 63
mixed cell tumors containing both neural ganglionic cells and neural glial cell components 44
ganglioglioma, no icd-o subtype 9


External Ids:

Disease Ontology9 DOID:5078
NCIt41 C3788
SNOMED-CT59 89880005
MeSH36 D018303
UMLS via Orphanet64 C0206716

Related Diseases for Ganglioglioma

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18GeneCards, 19GeneDecks
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Diseases related to Ganglioglioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 119)
idRelated DiseaseScoreTop Affiliating Genes
1dysembryoplastic neuroepithelial tumor30.5SYP
2astrocytoma30.3S100B, SYP, NES, APOD, GFAP
3rhabdoid tumor30.3ACTC1, SYP
4meningioma30.1SYP, GFAP, S100B
5glioblastoma multiforme30.1NES, MYCN, GFAP
6tuberous sclerosis30.1GFAP, NES, SYP, S100B
7giant cell glioblastoma30.1GFAP
8anaplastic ependymoma30.0S100B, GFAP
9pilocytic astrocytoma30.0NES, SYP, S100B, APOD, GFAP
10neuroblastoma30.0SYP, MYCN
11ganglioneuroblastoma29.9S100B, SYP, MYCN
12oligodendroglioma29.9SYP, APOD, GFAP
13ependymoma29.9S100B, GFAP, SYP, NES
14alzheimer's disease29.8SYP, S100B, GFAP, APOD
15neurofibroma29.8S100B, APOD, SYP, ACTC1
16desmoplastic infantile ganglioglioma10.8
17anaplastic ganglioglioma10.7
18cerebritis10.5
19neuronitis10.4
20pleomorphic xanthoastrocytoma10.4
21neurofibromatosis10.3
22gangliocytoma10.3
23desmoplastic infantile astrocytoma/ganglioglioma10.2
24atypical teratoid rhabdoid tumor10.2
25nasal ganglioglioma10.2
26medulloepithelioma10.1SYP
27melanotic neuroectodermal tumor10.1SYP
28choroid plexus papilloma10.1GFAP
29histiocytosis10.1S100B
30cerebral primitive neuroectodermal tumor10.1MYCN
31myxopapillary ependymoma10.1S100B, GFAP
32cervicitis10.1
33hydrocephalus10.1
34primitive neuroectodermal tumor10.1
35desmoplastic infantile astrocytoma10.1
36choroid plexus carcinoma10.1S100B, GFAP
37gemistocytic astrocytoma10.1S100B, GFAP
38syringoma10.1GFAP, S100B
39subependymal giant cell astrocytoma10.1SYP, S100B
40olfactory neuroblastoma10.1SYP, S100B
41binswanger's disease10.1GFAP, SYP
42central neurocytoma10.1SYP, GFAP
43granular cell tumor10.1SYP, S100B
44pineoblastoma10.1SYP, GFAP
45chordoma10.1S100B, GFAP
46creutzfeldt-jakob disease10.0NES, S100B
47neuroendocrine carcinoma10.0SYP, S100B
48male breast cancer10.0SYP, APOD
49prion disease10.0GFAP, SYP
50papillary ependymoma10.0SYP, GFAP, S100B

Graphical network of the top 20 diseases related to Ganglioglioma:



Diseases related to ganglioglioma

Symptoms for Ganglioglioma

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Drugs & Therapeutics for Ganglioglioma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Ganglioglioma

Genetic Tests for Ganglioglioma

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Anatomical Context for Ganglioglioma

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34MalaCards
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MalaCards organs/tissues related to Ganglioglioma:

34
Brain, Spinal cord, Temporal lobe, Cerebellum, Pineal, Cortex, Thalamus, Occipital lobe, Parietal lobe, Medulla oblongata

Animal Models for Ganglioglioma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Ganglioglioma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.9SYP, NES, MYCN, APOD, GFAP
2MP:00028737.8S100B, SYP, ACTC1, MYCN, GFAP
3MP:00053867.7GFAP, APOD, MYCN, NES, S100B

Publications for Ganglioglioma

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53PubMed
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Articles related to Ganglioglioma:

(show top 50)    (show all 367)
idTitleAuthorsYear
1
Ganglioglioma mimicking the cerebral abscess in advanced age: a case report. (24101283)
2013
2
Hemorrhagic ganglioglioma of the posterior fossa: case report. (24192758)
2013
3
Ganglioglioma with anaplastic transformation. (22990737)
2012
4
Anaplastic ganglioglioma: a very rare intramedullary spinal cord tumor. (22922809)
2012
5
Composite ganglioglioma/dysembryoplastic neuroepithelial tumor: a clinicopathologic study of 8 cases. (22221701)
2012
6
Strong desmin expression in a congenital desmoplastic infantile ganglioglioma mimicking pleomorphic rhadomyosarcoma: a case report including ultrastructural and cytogenetic evaluation and review of the literature. (22899016)
2012
7
Ganglioglioma of the thoracolumbar spinal cord in a patient with neurofibromatosis type 1: a case report and literature review. (22041518)
2011
8
Intraventricular ganglioglioma with bleed: a rare case report. (20644285)
2010
9
Primary malignant ganglioglioma of the dorsolumbar spine (D11-L1). (20817466)
2010
10
Ganglioglioma in the cerebellopontine angle of an adult without seizures. (19772036)
2009
11
Minimum apparent diffusion coefficient for the differential diagnosis of ganglioglioma. (19138470)
2009
12
Intraventricular ganglioglioma: a short illustrated review. (19290468)
2009
13
Desmoplastic infantile ganglioglioma with a malignant course. (18352812)
2008
14
Anaplastic ganglioglioma in a middle-aged woman: a case report with a review of the literature. (17923741)
2007
15
Desmoplastic infantile ganglioglioma/astrocytoma with cerebrospinal metastasis. (17386372)
2007
16
Malignant and benign ganglioglioma: a pathological and molecular study. (17259542)
2007
17
Spinal cord ganglioglioma presenting as acute paraparesis. (15946791)
2006
18
Anaplastic ganglioglioma of the cerebellopontine angle. Case report. (16308520)
2005
19
Desmoplastic non-infantile ganglioglioma. (15875908)
2005
20
Cyanotic breath-holding spell: a life-threatening complication after radical resection of a cervicomedullary ganglioglioma. (15942280)
2005
21
Conventional MR imaging with simultaneous measurements of cerebral blood volume and vascular permeability in ganglioglioma. (15172052)
2004
22
Residents' corner. Answer to case of the month #96. Right frontal lobe ganglioglioma. (15131935)
2004
23
Desmoplastic infantile astrocytoma and ganglioglioma: a search for genomic characteristics. (12111357)
2002
24
Desmoplastic infantile ganglioglioma: a potentially malignant tumor? (12409729)
2002
25
Congenital ganglioglioma. (12003306)
2002
26
Ganglioglioma of the lateral ventricle presenting with blepharospasm - case report and review of the literature. (11386809)
2001
27
Intraventricular trigonal ganglioglioma arising from the choroid plexus. (11685629)
2001
28
Malignant transformation of a gangliocytoma/ganglioglioma into a glioblastoma multiforme: a molecular genetic analysis. Case report. (11453385)
2001
29
Intracranial ganglioglioma. (10769518)
2000
30
Tuberin expression in ganglioglioma. (10808554)
2000
31
Coexistence of a ganglioglioma and Rasmussen's encephalitis. (10461077)
1999
32
Malignant glial tumor arising from the site of a previous hamartoma/ganglioglioma: coincidence or malignant transformation? (10352415)
1999
33
Intraventricular ganglioglioma: case report. (9689626)
1998
34
Telomere associations in desmoplastic infantile ganglioglioma. (8956861)
1996
35
Image interpretation session. Ganglioglioma. (7899606)
1995
36
Anaplastic ganglioglioma: case report and review of the literature. (7984264)
1994
37
Ganglioglioma of the mastoid region: a case report. (8455853)
1993
38
Chronic neurological dysfunction attributable to a ganglioglioma. (1398525)
1992
39
Cerebral ganglioglioma with long history and unusual prominence of the mesenchymal elements. Case report. (1297930)
1992
40
Hemifacial spasm in an infant due to fourth ventricular ganglioglioma. Case report. (2045898)
1991
41
Cerebral ganglioglioma and neurofibromatosis type I. Case report and review of the literature. (1922756)
1991
42
Intracranial ganglioglioma: MR imaging. (2119137)
1990
43
Ganglioglioma containing osseous tissue and neurofibrillary tangles. (3132128)
1988
44
Ganglioglioma of the spinal cord in a calf. (3576915)
1987
45
The occurrence of catecholamine neurons in a parietal lobe ganglioglioma. (2887276)
1987
46
Unilateral hemispheric ganglioglioma with infantile spasms. (7425564)
1980
47
Cerebellar ganglioglioma. Case report. (479941)
1979
48
Cerebellar ganglioglioma in a child. (219154)
1979
49
Ganglioglioma of the cerebellum: angiographic findings. (951566)
1976
50
Intraocular ganglioglioma in a dog. (5393729)
1969

Variations for Ganglioglioma

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Expression for genes affiliated with Ganglioglioma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ganglioglioma

Search GEO for disease gene expression data for Ganglioglioma.

Pathways for genes affiliated with Ganglioglioma

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51PathCards, 56Reactome, 13EMD Millipore, 61Thomson Reuters, 5Cell Signaling Technology
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Pathways related to Ganglioglioma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7S100B, GFAP
2
Show member pathways
Cytoskeleton remodeling Neurofilaments61
9.5NES, GFAP
38.7S100B, SYP, MYCN, GFAP

Compounds for genes affiliated with Ganglioglioma

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46Novoseek, 25HMDB, 30IUPHAR, 52PharmGKB, 12DrugBank, 62Tocris Bioscience
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Compounds related to Ganglioglioma according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1eosin4610.0GFAP, S100B
22,3-cyclic nucleotide4610.0S100B, GFAP
3n-acetylaspartate469.9GFAP, SYP
4homovanillic acid46 2510.8GFAP, MYCN
5l-amino acid469.8S100B, SYP
6orcein469.6S100B, ACTC1
72-mercaptoethanol469.5NES, GFAP
8acth469.5S100B, SYP, GFAP
9streptozotocin469.5SYP, NES, GFAP
10catecholamine469.5MYCN, SYP, S100B
11ganglioside469.5GFAP, NES, SYP
12kainate46 3010.5GFAP, NES, SYP
13ethanol46 52 25 1212.4GFAP, SYP, S100B
14etoposide46 52 62 1212.3MYCN, SYP, S100B
15dutp469.3SYP, GFAP
16agarose469.3S100B, MYCN, APOD
17mucicarmine469.3S100B, SYP, ACTC1
18forskolin46 52 1211.2S100B, SYP, GFAP
19b 723469.2S100B, SYP, ACTC1
20dbc-amp469.1S100B, SYP, MYCN, GFAP
21potassium46 25 1211.1GFAP, SYP, S100B
22choline46 25 1211.1S100B, SYP, NES, GFAP
23gaba469.1GFAP, NES, SYP, S100B
24acetylcholine46 52 30 25 1213.1GFAP, NES, SYP, S100B
25phospholipid469.1APOD, SYP, S100B
26bromodeoxyuridine469.1GFAP, MYCN, NES, S100B
27leucine469.1GFAP, MYCN, SYP, S100B
28glutamate469.0S100B, SYP, NES, GFAP
29matrigel468.9ACTC1, NES, GFAP
30nitric oxide46 25 1210.9MYCN, NES, SYP, S100B
31s 100468.9S100B, SYP, ACTC1, GFAP
32reticulin468.9GFAP, ACTC1, SYP, S100B
33hematoxylin468.9GFAP, ACTC1, SYP, S100B
34formaldehyde46 259.8GFAP, ACTC1, SYP, S100B
35glycogen46 259.8S100B, SYP, ACTC1, GFAP
36iron46 259.7S100B, ACTC1, MYCN, GFAP
37dexamethasone46 52 30 1211.7GFAP, ACTC1, SYP, S100B
38dopamine46 30 25 1211.6GFAP, MYCN, NES, SYP, S100B
39oxygen46 259.5S100B, ACTC1, NES, GFAP
40steroid468.5APOD, ACTC1, SYP, S100B
41lipid468.5GFAP, APOD, NES, SYP, S100B
42creatinine468.2GFAP, APOD, ACTC1, SYP, S100B
43testosterone46 62 25 1211.2GFAP, APOD, ACTC1, SYP, S100B
44glucose468.1GFAP, APOD, NES, ACTC1, S100B
45vegf467.8GFAP, MYCN, NES, ACTC1, SYP, S100B
46tyrosine467.8GFAP, MYCN, NES, ACTC1, SYP, S100B
47progesterone46 30 62 25 1211.7GFAP, APOD, NES, ACTC1, SYP, S100B
48estrogen467.7GFAP, APOD, NES, ACTC1, SYP, S100B
49paraffin467.2S100B, GFAP, APOD, MYCN, NES, ACTC1
50retinoic acid46 258.2GFAP, APOD, MYCN, NES, ACTC1, SYP

GO Terms for genes affiliated with Ganglioglioma

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17Gene Ontology
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Cellular components related to Ganglioglioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.5NES, GFAP

Biological processes related to Ganglioglioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1central nervous system developmentGO:0074179.6S100B, NES
2regulation of neuronal synaptic plasticityGO:0481689.5S100B, SYP
3long-term synaptic potentiationGO:0602919.4S100B, GFAP

Molecular functions related to Ganglioglioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cholesterol bindingGO:0154859.4SYP, APOD

Products for genes affiliated with Ganglioglioma

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Sources for Ganglioglioma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet