MCID: GNG004
MIFTS: 52

Ganglioglioma malady

Categories: Rare diseases, Neuronal diseases, Cancer diseases

Aliases & Classifications for Ganglioglioma

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Sources:
10Disease Ontology, 45NIH Rare Diseases, 47Novoseek, 12DISEASES, 51Orphanet, 36MeSH, 65UMLS, 42NCIt, 59SNOMED-CT, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Ganglioglioma:

Name: Ganglioglioma 10 45 47 12 51 36 65
Childhood Ganglioglioma 10 65
Adult Ganglioglioma 10 65
 
Mixed Cell Tumors Containing Both Neural Ganglionic Cells and Neural Glial Cell Components 45
Cns Ganglioglioma 10

Classifications:



External Ids:

Disease Ontology10 DOID:5078
MeSH36 D018303
SNOMED-CT59 89880005
Orphanet51 251949
UMLS via Orphanet66 C0206716
UMLS65 C0206716, C1332202, C1332969

Summaries for Ganglioglioma

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NIH Rare Diseases:45 A ganglioglioma is a rare type of brain tumor, accounting for approximately 1% of all brain tumors.  gangliogliomas occur when a single cell in the brain starts to divide into more cells, forming a tumor.  this can occur when the cell randomly acquires changes (mutations) in genes that regulate how a cell divides.  most gangliogliomas grow slowly and are considered benign.  however, up to 10% of gangliogliomas may grow more rapidly and become malignant, meaning the tumor affects the surrounding brain tissue.    the main treatment for ganglioglioma is removal of the entire tumor during surgery.  if the entire tumor is not removed, it has the potential to recur and may require additional surgery or treatments, such as radiation therapy or chemotherapy.  unfortunately, because gangliogliomas are quite rare, there is limited information to show that radiation therapy or chemotherapy are effective treatments for this condition. last updated: 7/11/2011

MalaCards based summary: Ganglioglioma, also known as childhood ganglioglioma, is related to pilocytic astrocytoma and pleomorphic xanthoastrocytoma, and has symptoms including seizures, seizures and seizures. An important gene associated with Ganglioglioma is SYP (Synaptophysin), and among its related pathways are Thyroid cancer and FSH signaling pathway. Affiliated tissues include brain, temporal lobe and spinal cord, and related mouse phenotypes are liver/biliary system and tumorigenesis.

Disease Ontology:10 A cell type benign neoplasm that has material basis in glial-type cells.

Wikipedia:68 Ganglioglioma is a rare, slow-growing primary central nervous system (CNS) tumor which most frequently... more...

Related Diseases for Ganglioglioma

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Diseases related to Ganglioglioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 217)
idRelated DiseaseScoreTop Affiliating Genes
1pilocytic astrocytoma30.8BRAF, TP53
2pleomorphic xanthoastrocytoma30.6BRAF, GFAP, SYP
3atypical teratoid rhabdoid tumor30.2GFAP, SMARCB1
4gliosarcoma29.7GFAP, TP53, TSC2
5anaplastic ganglioglioma12.3
6desmoplastic infantile ganglioglioma12.1
7nasal ganglioglioma12.0
8desmoplastic infantile astrocytoma/ganglioglioma12.0
9malignant pineal area germ cell neoplasm10.7BRAF, SYP
10splenogonadal fusion limb defects micrognatia10.7BRAF, TP53
11herpes simplex10.7BRAF, TP53
12brain glioma10.7SYP, TP53
13chronic rhinitis10.7SYP, TP53
14fallopian tube serous papilloma10.6SYP, TP53
15myeloma10.6SYP, TP53
16fallopian tube teratoma10.6SYP, TP53
17rectum kaposi's sarcoma10.6SMARCB1, SYP
18gangliocytoma10.6
19pleomorphic carcinoma10.6SYP, TP53
20anal gland neoplasm10.6SMARCB1, SYP
21cardiovascular organ benign neoplasm10.6SYP, TP53
22vulval paget's disease10.5SMARCB1, TP53
23urinary bladder villous adenoma10.5GFAP, SYP
24adult malignant schwannoma10.5GFAP, SYP
25skin glomus tumor10.5GFAP, SYP
26anovulation10.5GFAP, SYP
27hypothalamic neoplasm10.5MAP2, SYP
28mixed glioma10.5GFAP, SYP
29familial primary hypomagnesemia with hypercalciuria and nephrocalcinosis with severe ocular involvement10.5GFAP, SYP
30mixed ductal-endocrine carcinoma10.5MAP2, SYP
31kidney rhabdoid cancer10.5SMARCB1, SYP
32bilateral hyperactive labyrinth10.5GFAP, SYP
33alveoli adenoma10.5GFAP, TP53
34pineal gland astrocytoma10.5GFAP, TP53
35ovarian mucinous cystadenofibroma10.5GFAP, TP53
36ependymoblastoma10.5GFAP, SYP
37myoblastoma10.5GFAP, SYP
38congenital disorder of glycosylation, type if10.5GFAP, TP53
39merrf syndrome10.5SMARCB1, TP53
40sympathetic neurilemmoma10.5GFAP, SYP
41lateral ventricle meningioma10.5GFAP, TP53
42behcet's syndrome arthropathy10.4GFAP, SYP
43childhood medulloblastoma10.4GFAP, SMARCB1
44birdshot chorioretinopathy10.4GFAP, SYP
45subependymal giant cell astrocytoma10.4GFAP, TP53
46eye disease10.4GFAP, TP53
47spinal cord oligodendroglioma10.4GFAP, SYP
48atypical polypoid adenomyoma10.4MAP2, SYP
49thrombophlebitis10.4GFAP, SMARCB1
50myxopapillary ependymoma10.4GFAP, TP53

Graphical network of the top 20 diseases related to Ganglioglioma:



Diseases related to ganglioglioma

Symptoms for Ganglioglioma

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UMLS symptoms related to Ganglioglioma:


seizures

Drugs & Therapeutics for Ganglioglioma

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Drugs for Ganglioglioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
DabrafenibapprovedPhase 27044462760, 44516822
Synonyms:
BRAF inhibitor GSK2118436
Dabrafenib
Dabrafenib Mesylate
 
GSK2118436
GSK2118436a
Tafinlar
dabrafenib
2Protein Kinase InhibitorsPhase 23162
3
Bevacizumabapproved, investigationalPhase 01875216974-75-3
Synonyms:
216974-75-3
Avastin
Avastin (TN)
Bevacizumab
Bevacizumab (genetical recombination)
 
Bevacizumab (genetical recombination) (JAN)
D06409
R-435
anti-VEGF monoclonal antibody
antiVEGF
bevacizumab
4
Irinotecanapproved, investigationalPhase 0104497682-44-5, 100286-90-660838
Synonyms:
(+)-Irinotecan
(4S)-4,11-DIETHYL-4-HYDROXY-3,14-DIOXO-3,4,12,14-TETRAHYDRO-1H-PYRANO[3',4':6,7]INDOLIZINO[1,2-B]QUINOLIN-9-YL 1,4'-BIPIPERIDINE-1'-CARBOXYLATE
(4S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-4,12-dihydro-1H-pyrano[3,4-f]quinolino[2,3-a]indolizin-9-yl 4-piperidylpiperidinecarboxylate
1u65
97682-44-5
AC-7469
AC1L1U0Z
AC1Q6PGI
BRD-K08547377-003-02-4
BSPBio_002346
Bio-0054
Biotecan
Biotecan (TN)
C16641
C33H38N4O6
CHEBI:105985
CHEMBL481
CID60838
CP0
Campothecin-11
Campto
Camptosar
 
Camptosar, Campto, CPT-11, Irinotecan
Camptothecin-11
D08086
DB00762
FT-0083650
HSDB 7607
IRINOTECAN HYDROCHLORIDE Trihydrate
IRINOTECAN, CPT-11
Irinotecan
Irinotecan (INN)
Irinotecan Hcl
Irinotecan Hydrochloride
Irinotecan Hydrochloride Trihydrate
Irinotecan [INN:BAN]
Irinotecan hydrochloride
Irinotecanum
Irinotecanum [INN-Latin]
LS-44589
NCI60_005051
NSC728073
S1198_Selleck
TL8006026
UNII-7673326042
irinotecan
5Topoisomerase InhibitorsPhase 04081
6topoisomerase I inhibitorsPhase 01131
7Antineoplastic Agents, PhytogenicPhase 04294
8Angiogenesis InhibitorsPhase 03688
9Angiogenesis Modulating AgentsPhase 03611

Interventional clinical trials:

idNameStatusNCT IDPhase
1Proton Radiotherapy for Pediatric Brain Tumors Requiring Partial Brain IrradiationRecruitingNCT01288235Phase 2
2Phase II Pediatric Study With Dabrafenib in HGG PatientsNot yet recruitingNCT02684058Phase 2
3Evaluation of FDOPA-PET/MRI in Pediatric Patients With CNS TumorsRecruitingNCT01999270Phase 0

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Cochrane evidence based reviews: ganglioglioma

Genetic Tests for Ganglioglioma

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Anatomical Context for Ganglioglioma

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MalaCards organs/tissues related to Ganglioglioma:

33
Brain, Temporal lobe, Spinal cord, Breast, Lung, Pineal, Prostate

Animal Models for Ganglioglioma or affiliated genes

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MGI Mouse Phenotypes related to Ganglioglioma:

38 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.8BRAF, SMARCB1, TP53, TSC1, TSC2
2MP:00020068.7BRAF, SMARCB1, TP53, TSC1, TSC2
3MP:00053808.2BRAF, NSD1, SMARCB1, TP53, TSC1, TSC2
4MP:00053678.1BRAF, CHGA, TP53, TSC1, TSC2
5MP:00053867.9BRAF, GFAP, MAP2, SYP, TP53, TSC1
6MP:00053797.8BRAF, CHGA, MAP2, TP53, TSC1, TSC2
7MP:00036317.4BRAF, GFAP, MAP2, SMARCB1, SYP, TP53
8MP:00053897.3BRAF, CHGA, MAP2, SMARCB1, TP53, TSC1
9MP:00053857.2BRAF, CHGA, GFAP, SMARCB1, TP53, TSC1
10MP:00053786.4BRAF, CHGA, GFAP, MAP2, SMARCB1, TP53
11MP:00107686.0BRAF, CHGA, GFAP, MAP2, NSD1, SMARCB1

Publications for Ganglioglioma

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Articles related to Ganglioglioma:

(show top 50)    (show all 422)
idTitleAuthorsYear
1
Ganglioglioma arising from olfactory sheath: A rare site of an uncommon tumor. (26874814)
2016
2
Growth hormone secreting pituitary adenoma with admixed gangliocytoma and ganglioglioma. (27068013)
2016
3
Successful Retreatment of a Child with a Refractory Brainstem Ganglioglioma with Vemurafenib. (26579623)
2016
4
An Unusual Case of Constitutional Mismatch Repair Deficiency Syndrome With Anaplastic Ganglioglioma, Colonic Adenocarcinoma, Osteosarcoma, Acute Myeloid Leukemia, and Signs of Neurofibromatosis Type 1: Case Report. (25850602)
2015
5
Anaplastic ganglioglioma: a report of three cases and review of the literature. (25862009)
2015
6
Non-infantile variant of desmoplastic ganglioglioma: Conventional and advanced MR imaging characteristics. (26246092)
2015
7
Response of recurrent BRAFV600E mutated ganglioglioma to Vemurafenib as single agent. (25524464)
2014
8
Ganglioglioma mimicking the cerebral abscess in advanced age: a case report. (24101283)
2013
9
Hemorrhagic ganglioglioma of the posterior fossa: case report. (24192758)
2013
10
Ganglioglioma with anaplastic transformation. (22990737)
2012
11
Anaplastic ganglioglioma: a very rare intramedullary spinal cord tumor. (22922809)
2012
12
Composite ganglioglioma/dysembryoplastic neuroepithelial tumor: a clinicopathologic study of 8 cases. (22221701)
2012
13
Intraventricular ganglioglioma with bleed: a rare case report. (20644285)
2010
14
Primary malignant ganglioglioma of the dorsolumbar spine (D11-L1). (20817466)
2010
15
Ganglioglioma in the cerebellopontine angle of an adult without seizures. (19772036)
2009
16
Desmoplastic infantile ganglioglioma with a malignant course. (18352812)
2008
17
Anaplastic ganglioglioma in a middle-aged woman: a case report with a review of the literature. (17923741)
2007
18
Desmoplastic infantile ganglioglioma/astrocytoma with cerebrospinal metastasis. (17386372)
2007
19
Malignant and benign ganglioglioma: a pathological and molecular study. (17259542)
2007
20
Spinal cord ganglioglioma presenting as acute paraparesis. (15946791)
2006
21
Anaplastic ganglioglioma of the cerebellopontine angle. Case report. (16308520)
2005
22
Desmoplastic non-infantile ganglioglioma. (15875908)
2005
23
Cyanotic breath-holding spell: a life-threatening complication after radical resection of a cervicomedullary ganglioglioma. (15942280)
2005
24
Conventional MR imaging with simultaneous measurements of cerebral blood volume and vascular permeability in ganglioglioma. (15172052)
2004
25
Residents' corner. Answer to case of the month #96. Right frontal lobe ganglioglioma. (15131935)
2004
26
Desmoplastic infantile astrocytoma and ganglioglioma: a search for genomic characteristics. (12111357)
2002
27
Desmoplastic infantile ganglioglioma: a potentially malignant tumor? (12409729)
2002
28
Congenital ganglioglioma. (12003306)
2002
29
Ganglioglioma of the lateral ventricle presenting with blepharospasm - case report and review of the literature. (11386809)
2001
30
Intraventricular trigonal ganglioglioma arising from the choroid plexus. (11685629)
2001
31
Malignant transformation of a gangliocytoma/ganglioglioma into a glioblastoma multiforme: a molecular genetic analysis. Case report. (11453385)
2001
32
Intracranial ganglioglioma. (10769518)
2000
33
Tuberin expression in ganglioglioma. (10808554)
2000
34
Coexistence of a ganglioglioma and Rasmussen's encephalitis. (10461077)
1999
35
Intraventricular ganglioglioma: case report. (9689626)
1998
36
Image interpretation session. Ganglioglioma. (7899606)
1995
37
Anaplastic ganglioglioma: case report and review of the literature. (7984264)
1994
38
Ganglioglioma of the mastoid region: a case report. (8455853)
1993
39
Chronic neurological dysfunction attributable to a ganglioglioma. (1398525)
1992
40
Cerebral ganglioglioma with long history and unusual prominence of the mesenchymal elements. Case report. (1297930)
1992
41
Hemifacial spasm in an infant due to fourth ventricular ganglioglioma. Case report. (2045898)
1991
42
Intracranial ganglioglioma: MR imaging. (2119137)
1990
43
Ganglioglioma containing osseous tissue and neurofibrillary tangles. (3132128)
1988
44
Ganglioglioma of the spinal cord in a calf. (3576915)
1987
45
The occurrence of catecholamine neurons in a parietal lobe ganglioglioma. (2887276)
1987
46
Cerebellar ganglioglioma. Case report. (479941)
1979
47
Cerebellar ganglioglioma in a child. (219154)
1979
48
Ganglioglioma of the cerebellum: angiographic findings. (951566)
1976
49
Intraocular ganglioglioma in a dog. (5393729)
1969
50

Variations for Ganglioglioma

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Expression for genes affiliated with Ganglioglioma

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Search GEO for disease gene expression data for Ganglioglioma.

Pathways for genes affiliated with Ganglioglioma

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Pathways related to Ganglioglioma according to GeneCards Suite gene sharing:

(show all 18)
idSuper pathwaysScoreTop Affiliating Genes
19.6BRAF, TP53
29.3CHGA, TSC2
39.3GFAP, MAP2, SYP
49.3TP53, TSC1, TSC2
5
Show member pathways
9.3TP53, TSC1, TSC2
6
Show member pathways
9.3TP53, TSC1, TSC2
7
Show member pathways
9.3TP53, TSC1, TSC2
8
Show member pathways
9.3TP53, TSC1, TSC2
9
Show member pathways
9.2SMARCB1, TSC1, TSC2
109.2BRAF, TSC1, TSC2
11
Show member pathways
9.1BRAF, MAP2, TP53
12
Show member pathways
8.8BRAF, TP53, TSC1, TSC2
13
Show member pathways
8.8BRAF, TP53, TSC1, TSC2
148.8BRAF, TP53, TSC1, TSC2
15
Show member pathways
8.8BRAF, TP53, TSC1, TSC2
168.8BRAF, TP53, TSC1, TSC2
178.7MAP2, TP53, TSC1, TSC2
18
Show member pathways
8.4CHGA, TP53, TSC1, TSC2

GO Terms for genes affiliated with Ganglioglioma

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Biological processes related to Ganglioglioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein localizationGO:00081049.8TP53, TSC2
2negative regulation of insulin receptor signaling pathwayGO:00466279.5TSC1, TSC2

Sources for Ganglioglioma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet