MCID: GNG008
MIFTS: 40

Ganglioneuroblastoma malady

Neuronal diseases, Cancer diseases, Rare diseases categories

Aliases & Classifications for Ganglioneuroblastoma

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 47Orphanet, 60UMLS, 38NCIt, 33MeSH, 55SNOMED-CT, 61UMLS via Orphanet
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Ganglioneuroblastoma, Aliases & Descriptions:

Name: Ganglioneuroblastoma 9 11 43 47 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

47
ganglioneuroblastoma:
Inheritance: Not applicable; Age of onset: Childhood,Infancy


External Ids:

Disease Ontology9 DOID:4163
NCIt38 C3790
MeSH33 D018305
SNOMED-CT55 69515008
Orphanet47 251877
UMLS via Orphanet61 C0206718

Summaries for Ganglioneuroblastoma

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Wikipedia:63 Ganglioneuroblastoma is a variant of neuroblastoma that is surrounded by ganglion cells. more...

MalaCards based summary: Ganglioneuroblastoma is related to neuroblastoma and paraganglioma. An important gene associated with Ganglioneuroblastoma is MYCN (v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog), and among its related pathways is Neuroscience. The compounds vanillylmandelic acid and pentylenetetrazol have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone and brain, and related mouse phenotypes are behavior/neurological and normal.

Related Diseases for Ganglioneuroblastoma

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Diseases related to Ganglioneuroblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 96)
idRelated DiseaseScoreTop Affiliating Genes
1neuroblastoma30.9SYP, MYCN, VIP
2paraganglioma30.2SYP, S100B
3cushing's syndrome30.1SYP, NPY
4ganglioglioma30.0S100B, SYP
5pheochromocytoma30.0VIP, MYCN, SYP, NPY
6neurofibroma30.0S100B, SYP
7adrenocortical carcinoma29.9SYP, VIP
8ganglioneuroma29.9VIP, MYCN, SYP, S100B, NPY
9cerebral primitive neuroectodermal tumor10.5MYCN
10diarrhea10.4
11hirschsprung disease 110.4VIP
12papilloma10.4MYCN
13nodular ganglioneuroblastoma10.4
14hirschsprung disease ganglioneuroblastoma10.4
15peripheral nervous system ganglioneuroblastoma10.3
16mediastinum ganglioneuroblastoma10.3
17mediastinitis10.3
18ataxia10.3
19dysembryoplastic neuroepithelial tumor10.3SYP
20glomus tumor10.3SYP
21neuronitis10.2
22adrenal gland ganglioneuroblastoma10.2
23cerebritis10.2
24sarcoma, synovial10.2S100B, MYCN
25sex cord-gonadal stromal tumor10.2NPY, S100B
26ewing sarcoma10.2S100B, MYCN
27intermixed schwannian stroma-rich ganglioneuroblastoma10.2
28stroma-dominant and stroma-poor composite ganglioneuroblastoma10.2
29schwannian stroma-rich and stroma-poor composite ganglioneuroblastoma10.2
30cervicitis10.2
31paraneoplastic syndromes10.2
32rhinitis10.1NPY, VIP
33papillary ependymoma10.1S100B, SYP
34subependymal giant cell astrocytoma10.1SYP, S100B
35olfactory neuroblastoma10.1SYP, S100B
36choroid plexus papilloma10.1S100B, SYP
37rhabdomyosarcoma10.1S100B, MYCN
38neuroblastoma 210.1
39wilms tumor10.1
40neurofibromatosis10.1
41gangliocytoma10.1
42osteomalacia10.1
43hypokalemia10.1
44phaeochromocytoma10.1
45turner syndrome10.1
46myoclonus10.1
47pineocytoma10.1S100B, SYP
48granular cell tumor10.1SYP, S100B
49hemangioblastoma10.1SYP, S100B
50pilocytic astrocytoma10.1SYP, S100B

Graphical network of the top 20 diseases related to Ganglioneuroblastoma:



Diseases related to ganglioneuroblastoma

Symptoms for Ganglioneuroblastoma

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Drugs & Therapeutics for Ganglioneuroblastoma

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Drug clinical trials:

Search ClinicalTrials for Ganglioneuroblastoma

Search NIH Clinical Center for Ganglioneuroblastoma

Genetic Tests for Ganglioneuroblastoma

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Anatomical Context for Ganglioneuroblastoma

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MalaCards organs/tissues related to Ganglioneuroblastoma:

31
Spinal cord, Bone, Brain, Adrenal gland, Bone marrow, Cerebellum, Kidney, Lung, Lymph node, Thymus, Colon, Myeloid, Pineal, Pituitary

Animal Models for Ganglioneuroblastoma or affiliated genes

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MGI Mouse Phenotypes related to Ganglioneuroblastoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.6NPY, S100B, MYCN, VIP
2MP:00028737.4NPY, S100B, SYP, MYCN, VIP

Publications for Ganglioneuroblastoma

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Articles related to Ganglioneuroblastoma:

(show top 50)    (show all 213)
idTitleAuthorsYear
1
Adult adrenal ganglioneuroblastoma: A rare case report. (25737766)
2015
2
Pediatric cerebral ganglioneuroblastoma. (25216629)
2014
3
Ventricular ganglioneuroblastoma in an adult and successful treatment with radiotherapy. (25207191)
2014
4
The neuroblastoma and ganglion components of nodular ganglioneuroblastoma are genetically similar: evidence against separate clonal origins. (25081755)
2014
5
Giant thoracoabdominal ganglioneuroblastoma in a 17-year-old patient. (24887835)
2013
6
Cerebral ganglioneuroblastoma of adult onset: two patients and a review of the literature. (22510501)
2012
7
Ganglioneuroblastoma: Case report and review of the literature. (23396255)
2011
8
Simultaneous tumors: acute myeloid leukemia infiltrating mediastinal ganglioneuroblastoma. (20973101)
2011
9
Ganglioneuroblastoma of the conus: a rare and aggressive tumor. (21150078)
2010
10
The low-affinity neurotrophin receptor, p75, is upregulated in ganglioneuroblastoma/ganglioneuroma and reduces tumorigenicity of neuroblastoma cells in vivo. (19142969)
2009
11
Nodular ganglioneuroblastoma in adults. (19680497)
2009
12
Genome analysis and gene expression profiling of neuroblastoma and ganglioneuroblastoma reveal differences between neuroblastic and Schwannian stromal cells. (16178058)
2005
13
Canine ganglioneuroblastoma in the oral mucosa. (15003480)
2004
14
Adult-type ganglioneuroblastoma in the adrenal gland treated by a laparoscopic resection: report of a case. (14513331)
2003
15
Shoulder pain in a child: a case presentation of ganglioneuroblastoma. (10754787)
2000
16
Primary pulmonary ganglioneuroblastoma: a clinicopathologic and immunohistochemical study of two cases. (9845734)
1998
17
Simultaneous adrenocortical carcinoma and ganglioneuroblastoma in a child with Turner syndrome and germline p53 mutation. (9598730)
1998
18
Ganglioneuroblastoma and ganglioneuroma in association with neurofibromatosis type I: report of three cases. (9701489)
1998
19
Adult ganglioneuroblastoma of the anterior mediastinum. (9505266)
1997
20
Cerebellin and cerebellin mRNA in the human brain, adrenal glands and the tumour tissues of adrenal tumour, ganglioneuroblastoma and neuroblastoma. (9246935)
1997
21
Central hypoventilation syndrome associated with ganglioneuroblastoma. (8555134)
1995
22
An immunohistochemical study of peripheral neuroblastoma, ganglioneuroblastoma, anaplastic ganglioglioma, schwannoma and neurofibroma in cattle. (7962722)
1994
23
Pathologic quiz case 1. Cervical ganglioneuroblastoma. (8318213)
1993
24
N-myc gene amplification/expression in localized stroma-rich neuroblastoma (ganglioneuroblastoma). (8454274)
1993
25
Isolation of chromosome-specific DNA sequences from an Alu polymerase chain reaction library to define the breakpoint in a patient with a constitutional translocation t(1;13) (q22;q12) and ganglioneuroblastoma. (1630820)
1992
26
An adrenaline-secreting ganglioneuroblastoma with elevated urinary HMMA but normal metanephrine excretion. (1489167)
1992
27
Neuropeptide Y as a plasma marker for phaeochromocytoma, ganglioneuroblastoma and neuroblastoma. (1327637)
1992
28
Intestinal ganglioneuroblastoma in a 22-week fetus. (1409156)
1992
29
Ganglioneuroblastoma and urticaria by physical agents. (2368174)
1990
30
Identification of 5-HT1A recognition sites in human ganglioneuroblastoma. (2575526)
1989
31
Bilateral adrenal ganglioneuroblastoma with neuromelanin. Clinical and pathologic observations. (3277701)
1988
32
False positive bone scan secondary to sympathectomy following resection of a ganglioneuroblastoma or affect of unilateral sympathectomy of bone scan in the pediatric patient. (3352830)
1988
33
Primary small bowel ganglioneuroblastoma and Friedreich's ataxia. (3585899)
1987
34
Cervical ganglioneuroblastoma. (3572236)
1987
35
Malignant pheochromocytoma with ganglioneuroblastoma elements in a patient with von Recklinghausen's disease. (3922614)
1985
36
The isolation and sequence analysis of vasoactive intestinal peptide from a ganglioneuroblastoma. (6092409)
1984
37
The role of surgery, radio- and chemotherapy in the treatment of neuroblastoma and ganglioneuroblastoma. (6878720)
1983
38
Extraosseous localization of 99mTc-MDP in ganglioneuroblastoma. (6214400)
1982
39
Primary pulmonary ganglioneuroblastoma in an adult: maturation, involution and the immune response. (7275023)
1981
40
Case report. Computer assisted tomographic evaluation of a ganglioneuroblastoma in an adult. (422782)
1979
41
Histopathological study of an imperfect type ganglioneuroblastoma. (462578)
1979
42
Intractable diarrhea in a boy with vasoactive intestinal peptide-producing ganglioneuroblastoma. (854377)
1977
43
Pigmented ganglioneuroblastoma: relation of melanin and lipofuscin to schwannomas and other tumors of neural crest origin. (180265)
1976
44
Bilateral adrenal ganglioneuroblastoma in a premature calf. (962741)
1976
45
Retroperitoneal ganglioneuroblastoma: a kaleidoscope of neuronal degeneration. A light and electron microscopic study. (173810)
1976
46
Ganglioneuroblastoma associated with malignant mesenchymoma. (1182658)
1975
47
Metastatic ganglioneuroblastoma: report of case and review of the literature. (4600171)
1974
48
Metastatic ganglioneuroblastoma. Ultrastructural, histochemical, and virological studies in a case. (5343392)
1969
49
Ganglioneuroblastoma: angiographic-histologic correlation. (5769305)
1969
50
Multiple tumors of the sympathetic nervous system: Report of a case showing a distinct ganglioneuroma, a neuroblastoma and a cystic calcifying ganglioneuroblastoma. (19970419)
1938

Variations for Ganglioneuroblastoma

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Expression for genes affiliated with Ganglioneuroblastoma

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Search GEO for disease gene expression data for Ganglioneuroblastoma.

Pathways for genes affiliated with Ganglioneuroblastoma

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Pathways related to Ganglioneuroblastoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
18.3NPY, S100B, SYP, MYCN

Compounds for genes affiliated with Ganglioneuroblastoma

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Compounds related to Ganglioneuroblastoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1vanillylmandelic acid43 2410.9MYCN, VIP
2pentylenetetrazol439.9NPY, S100B
3arginine vasotocin439.8VIP, NPY
4secretoneurin439.8VIP, NPY
5helospectin439.8VIP, NPY
6methoxamine43 28 1211.8NPY, VIP
7pacap 38439.8NPY, VIP
8guanethidine43 1210.8VIP, NPY
9alpha msh439.8NPY, VIP
10phentolamine43 28 1211.7VIP, NPY
11oxyntomodulin43 5910.7VIP, NPY
12trifluoroethanol43 1210.7NPY, VIP
13phosphoramidon43 1210.6VIP, NPY
14s 100439.6S100B, SYP
15reticulin439.5SYP, S100B
16mucicarmine439.5S100B, SYP
17pertussis439.4VIP, NPY
18l-amino acid439.4S100B, SYP
19sodium nitroprusside439.4VIP, S100B, NPY
20b 723439.4SYP, S100B
216-hydroxydopamine439.1NPY, VIP
22etoposide43 49 59 1212.1S100B, SYP, MYCN
23formaldehyde43 2410.0NPY, S100B, SYP
24streptozotocin439.0NPY, SYP
25haloperidol43 49 28 2 1213.0VIP, SYP, NPY
265-hydroxytryptamine439.0VIP, SYP, NPY
27lactate439.0NPY, S100B, MYCN, VIP
28histamine43 28 2410.8VIP, SYP, NPY
29potassium43 24 1210.8S100B, SYP, VIP
30gtp43 289.7S100B, SYP, VIP
31dbc-amp438.7VIP, MYCN, SYP, S100B
32paraffin438.7NPY, S100B, SYP, MYCN
33creatinine438.7NPY, S100B, SYP
34vegf438.6VIP, MYCN, SYP, S100B
35choline43 24 1210.6NPY, S100B, SYP, VIP
36acth438.6VIP, SYP, S100B, NPY
37gaba438.6NPY, S100B, SYP, VIP
38norepinephrine43 24 1210.6NPY, S100B, SYP, VIP
39acetylcholine43 49 28 24 1212.6VIP, SYP, S100B, NPY
40forskolin43 49 1210.6VIP, SYP, S100B, NPY
41glutamine438.6VIP, SYP, S100B, NPY
42cyclic amp43 249.6NPY, S100B, SYP, VIP
43retinoic acid43 249.5MYCN, SYP, S100B, NPY
44testosterone43 59 24 1211.5VIP, SYP, S100B, NPY
45glutamate438.5VIP, SYP, S100B, NPY
46estrogen438.4VIP, SYP, S100B, NPY
47catecholamine438.2NPY, S100B, SYP, MYCN, VIP
48dopamine43 28 24 1211.2VIP, MYCN, SYP, S100B, NPY
49nitric oxide43 24 1210.2VIP, MYCN, SYP, S100B, NPY
50tyrosine438.1VIP, MYCN, SYP, S100B, NPY

GO Terms for genes affiliated with Ganglioneuroblastoma

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Biological processes related to Ganglioneuroblastoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1regulation of cell shapeGO:00083609.4S100B, WASF3
2learning or memoryGO:00076119.2S100B, VIP
3regulation of neuronal synaptic plasticityGO:00481689.1S100B, SYP

Molecular functions related to Ganglioneuroblastoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:00051849.4NPY, VIP

Products for genes affiliated with Ganglioneuroblastoma

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Sources for Ganglioneuroblastoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet