MCID: GNG008
MIFTS: 46

Ganglioneuroblastoma malady

Neuronal diseases, Cancer diseases, Rare diseases categories
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Summaries for Ganglioneuroblastoma

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65Wikipedia, 33MalaCards
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Wikipedia:65 Ganglioneuroblastoma is a variant of neuroblastoma that is surrounded by ganglion cells. more...

MalaCards: Ganglioneuroblastoma is related to neuroblastoma and ganglioneuroma. An important gene associated with Ganglioneuroblastoma is MYCN (v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog), and among its related pathways is Neuroscience. The compounds vanillylmandelic acid and pentylenetetrazol have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, adrenal gland and brain, and related mouse phenotypes are behavior/neurological and normal.

Aliases & Classifications for Ganglioneuroblastoma

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8Disease Ontology, 10DISEASES, 45Novoseek, 49Orphanet, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH, 63UMLS via Orphanet, 59SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

49
ganglioneuroblastoma:
Inheritance: Sporadic; Age of onset: Childhood


Aliases & Descriptions:

ganglioneuroblastoma 8 10 45 49 62


External Ids:

Disease Ontology8 DOID:4163
NCIt40 C3790
MeSH35 D018305
SNOMED-CT58 69515008
UMLS via Orphanet63 C0206718
SNOMED-CT via Orphanet59 69515008

Related Diseases for Ganglioneuroblastoma

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17GeneCards, 18GeneDecks
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Diseases related to Ganglioneuroblastoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 97)
idRelated DiseaseScoreTop Affiliating Genes
1neuroblastoma31.0MYCN, VIP, SYP
2ganglioneuroma30.5VIP, MYCN, SYP, S100B, NPY
3pheochromocytoma30.4VIP, MYCN, SYP, NPY
4paraganglioma30.1S100B, SYP
5cushing's syndrome30.1NPY, SYP
6ganglioglioma29.9S100B, SYP
7neurofibroma29.9SYP, S100B
8adrenocortical carcinoma29.9SYP, VIP
9diarrhea10.4
10nodular ganglioneuroblastoma10.3
11hirschsprung disease ganglioneuroblastoma10.3
12mediastinitis10.3
13ataxia10.3
14peripheral nervous system ganglioneuroblastoma10.2
15neuronitis10.2
16mediastinum ganglioneuroblastoma10.2
17adrenal gland ganglioneuroblastoma10.2
18cerebritis10.2
19cervicitis10.2
20paraneoplastic syndromes10.2
21cerebral primitive neuroectodermal tumor10.1MYCN
22papilloma10.1MYCN
23hirschsprung's disease10.1VIP
24neurofibromatosis10.1
25intermixed schwannian stroma-rich ganglioneuroblastoma10.1
26stroma-dominant and stroma-poor composite ganglioneuroblastoma10.1
27schwannian stroma-rich and stroma-poor composite ganglioneuroblastoma10.1
28hypokalemia10.1
29phaeochromocytoma10.1
30hypertension10.1
31turner syndrome10.1
32wilms tumor10.1
33myoclonus10.1
34dysembryoplastic neuroepithelial tumor10.1SYP
35glomus tumor10.1SYP
36synovial sarcoma10.1S100B, MYCN
37neuroepithelioma10.1NPY, MYCN
38sex cord-gonadal stromal tumor10.0S100B, NPY
39peripheral primitive neuroectodermal tumor10.0S100B, MYCN
40rhinitis10.0NPY, VIP
41papillary ependymoma10.0SYP, S100B
42olfactory neuroblastoma10.0SYP, S100B
43subependymal giant cell astrocytoma10.0S100B, SYP
44choroid plexus papilloma10.0S100B, SYP
45rhabdomyosarcoma10.0S100B, MYCN
46pineocytoma10.0S100B, SYP
47granular cell tumor10.0S100B, SYP
48hemangioblastoma10.0SYP, S100B
49pilocytic astrocytoma10.0S100B, SYP
50pancreatic islet cell tumors10.0VIP, SYP

Graphical network of the top 20 diseases related to Ganglioneuroblastoma:



Diseases related to ganglioneuroblastoma

Symptoms for Ganglioneuroblastoma

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Drugs & Therapeutics for Ganglioneuroblastoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Ganglioneuroblastoma

Search NIH Clinical Center for Ganglioneuroblastoma

Genetic Tests for Ganglioneuroblastoma

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Anatomical Context for Ganglioneuroblastoma

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33MalaCards
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MalaCards organs/tissues related to Ganglioneuroblastoma:

33
Spinal cord, Adrenal gland, Brain, Bone, Bone marrow, Pituitary, Pineal, Myeloid, Colon, Thymus, Lymph node, Lung, Kidney, Cerebellum

Animal Models for Ganglioneuroblastoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Ganglioneuroblastoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.6NPY, S100B, MYCN, VIP
2MP:00028737.4NPY, S100B, SYP, MYCN, VIP

Publications for Ganglioneuroblastoma

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52PubMed
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Articles related to Ganglioneuroblastoma:

(show top 50)    (show all 203)
idTitleAuthorsYear
1
Cerebral ganglioneuroblastoma of adult onset: two patients and a review of the literature. (22510501)
2012
2
Ganglioneuroblastoma: Case report and review of the literature. (23396255)
2011
3
Simultaneous tumors: acute myeloid leukemia infiltrating mediastinal ganglioneuroblastoma. (20973101)
2011
4
Ganglioneuroblastoma of the conus: a rare and aggressive tumor. (21150078)
2010
5
The low-affinity neurotrophin receptor, p75, is upregulated in ganglioneuroblastoma/ganglioneuroma and reduces tumorigenicity of neuroblastoma cells in vivo. (19142969)
2009
6
Nodular ganglioneuroblastoma in adults. (19680497)
2009
7
Genome analysis and gene expression profiling of neuroblastoma and ganglioneuroblastoma reveal differences between neuroblastic and Schwannian stromal cells. (16178058)
2005
8
Canine ganglioneuroblastoma in the oral mucosa. (15003480)
2004
9
Adult-type ganglioneuroblastoma in the adrenal gland treated by a laparoscopic resection: report of a case. (14513331)
2003
10
Expression of melanin-concentrating hormone receptor messenger ribonucleic acid in tumor tissues of pheochromocytoma, ganglioneuroblastoma, and neuroblastoma. (11232026)
2001
11
Shoulder pain in a child: a case presentation of ganglioneuroblastoma. (10754787)
2000
12
Primary pulmonary ganglioneuroblastoma: a clinicopathologic and immunohistochemical study of two cases. (9845734)
1998
13
Simultaneous adrenocortical carcinoma and ganglioneuroblastoma in a child with Turner syndrome and germline p53 mutation. (9598730)
1998
14
Ganglioneuroblastoma and ganglioneuroma in association with neurofibromatosis type I: report of three cases. (9701489)
1998
15
Adult ganglioneuroblastoma of the anterior mediastinum. (9505266)
1997
16
Cerebellin and cerebellin mRNA in the human brain, adrenal glands and the tumour tissues of adrenal tumour, ganglioneuroblastoma and neuroblastoma. (9246935)
1997
17
Pelvic ganglioneuroblastoma totally excised using posterior sagittal and abdominal approach. (24057564)
1996
18
Central hypoventilation syndrome associated with ganglioneuroblastoma. (8555134)
1995
19
An immunohistochemical study of peripheral neuroblastoma, ganglioneuroblastoma, anaplastic ganglioglioma, schwannoma and neurofibroma in cattle. (7962722)
1994
20
Thoracic ganglioneuroblastoma in a dog. (7863591)
1994
21
Pathologic quiz case 1. Cervical ganglioneuroblastoma. (8318213)
1993
22
N-myc gene amplification/expression in localized stroma-rich neuroblastoma (ganglioneuroblastoma). (8454274)
1993
23
Isolation of chromosome-specific DNA sequences from an Alu polymerase chain reaction library to define the breakpoint in a patient with a constitutional translocation t(1;13) (q22;q12) and ganglioneuroblastoma. (1630820)
1992
24
An adrenaline-secreting ganglioneuroblastoma with elevated urinary HMMA but normal metanephrine excretion. (1489167)
1992
25
Neuropeptide Y as a plasma marker for phaeochromocytoma, ganglioneuroblastoma and neuroblastoma. (1327637)
1992
26
Intestinal ganglioneuroblastoma in a 22-week fetus. (1409156)
1992
27
Ganglioneuroblastoma and urticaria by physical agents. (2368174)
1990
28
Identification of 5-HT1A recognition sites in human ganglioneuroblastoma. (2575526)
1989
29
Bilateral adrenal ganglioneuroblastoma with neuromelanin. Clinical and pathologic observations. (3277701)
1988
30
False positive bone scan secondary to sympathectomy following resection of a ganglioneuroblastoma or affect of unilateral sympathectomy of bone scan in the pediatric patient. (3352830)
1988
31
Lumbar dumbbell ganglioneuroblastoma: a light and electron microscopic study of neuronal degeneration. (3251147)
1988
32
Primary small bowel ganglioneuroblastoma and Friedreich's ataxia. (3585899)
1987
33
Cervical ganglioneuroblastoma. (3572236)
1987
34
Malignant pheochromocytoma with ganglioneuroblastoma elements in a patient with von Recklinghausen's disease. (3922614)
1985
35
The isolation and sequence analysis of vasoactive intestinal peptide from a ganglioneuroblastoma. (6092409)
1984
36
The role of surgery, radio- and chemotherapy in the treatment of neuroblastoma and ganglioneuroblastoma. (6878720)
1983
37
Extraosseous localization of 99mTc-MDP in ganglioneuroblastoma. (6214400)
1982
38
Primary pulmonary ganglioneuroblastoma in an adult: maturation, involution and the immune response. (7275023)
1981
39
Intrathoracic ganglioneuroblastoma. (7421294)
1980
40
Case report. Computer assisted tomographic evaluation of a ganglioneuroblastoma in an adult. (422782)
1979
41
Histopathological study of an imperfect type ganglioneuroblastoma. (462578)
1979
42
Intractable diarrhea in a boy with vasoactive intestinal peptide-producing ganglioneuroblastoma. (854377)
1977
43
Pigmented ganglioneuroblastoma: relation of melanin and lipofuscin to schwannomas and other tumors of neural crest origin. (180265)
1976
44
Bilateral adrenal ganglioneuroblastoma in a premature calf. (962741)
1976
45
Retroperitoneal ganglioneuroblastoma: a kaleidoscope of neuronal degeneration. A light and electron microscopic study. (173810)
1976
46
Ganglioneuroblastoma associated with malignant mesenchymoma. (1182658)
1975
47
Metastatic ganglioneuroblastoma: report of case and review of the literature. (4600171)
1974
48
Metastatic ganglioneuroblastoma. Ultrastructural, histochemical, and virological studies in a case. (5343392)
1969
49
Ganglioneuroblastoma: angiographic-histologic correlation. (5769305)
1969
50
Multiple tumors of the sympathetic nervous system: Report of a case showing a distinct ganglioneuroma, a neuroblastoma and a cystic calcifying ganglioneuroblastoma. (19970419)
1938

Variations for Ganglioneuroblastoma

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Expression for genes affiliated with Ganglioneuroblastoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ganglioneuroblastoma

Search GEO for disease gene expression data for Ganglioneuroblastoma.

Pathways for genes affiliated with Ganglioneuroblastoma

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50PathCards, 5Cell Signaling Technology
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Pathways related to Ganglioneuroblastoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
18.3NPY, S100B, SYP, MYCN

Compounds for genes affiliated with Ganglioneuroblastoma

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Sources:
45Novoseek, 24HMDB, 29IUPHAR, 11DrugBank, 61Tocris Bioscience, 51PharmGKB, 3BitterDB
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Compounds related to Ganglioneuroblastoma according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1vanillylmandelic acid45 2410.9VIP, MYCN
2pentylenetetrazol459.9S100B, NPY
3secretoneurin459.8NPY, VIP
4helospectin459.8VIP, NPY
5arginine vasotocin459.8NPY, VIP
6methoxamine45 29 1111.8NPY, VIP
7pacap 38459.8VIP, NPY
8guanethidine45 1110.8NPY, VIP
9alpha msh459.8VIP, NPY
10phentolamine45 29 1111.7VIP, NPY
11oxyntomodulin45 6110.7VIP, NPY
12trifluoroethanol45 1110.7NPY, VIP
13phosphoramidon45 1110.6NPY, VIP
14s 100459.6SYP, S100B
15reticulin459.5S100B, SYP
16mucicarmine459.5S100B, SYP
17pertussis459.4NPY, VIP
18l-amino acid459.4SYP, S100B
19sodium nitroprusside459.4NPY, S100B, VIP
20b 723459.4SYP, S100B
216-hydroxydopamine459.1VIP, NPY
22etoposide45 51 61 1112.1SYP, S100B, MYCN
23formaldehyde45 2410.0SYP, S100B, NPY
24streptozotocin459.0NPY, SYP
25haloperidol45 51 29 3 1113.0VIP, NPY, SYP
265-hydroxytryptamine459.0NPY, SYP, VIP
27lactate459.0NPY, S100B, MYCN, VIP
28histamine45 29 2410.8NPY, VIP, SYP
29potassium45 24 1110.8VIP, S100B, SYP
30gtp45 299.7S100B, VIP, SYP
31dbc-amp458.7SYP, S100B, VIP, MYCN
32paraffin458.7S100B, NPY, MYCN, SYP
33creatinine458.7NPY, S100B, SYP
34vegf458.6SYP, S100B, VIP, MYCN
35choline45 24 1110.6VIP, NPY, S100B, SYP
36acth458.6NPY, S100B, SYP, VIP
37gaba458.6NPY, SYP, VIP, S100B
38norepinephrine45 24 1110.6S100B, SYP, VIP, NPY
39acetylcholine45 51 29 24 1112.6VIP, NPY, SYP, S100B
40forskolin45 51 1110.6S100B, SYP, NPY, VIP
41glutamine458.6S100B, NPY, VIP, SYP
42cyclic amp45 249.6S100B, SYP, VIP, NPY
43retinoic acid45 249.5NPY, MYCN, SYP, S100B
44testosterone45 61 24 1111.5SYP, NPY, S100B, VIP
45glutamate458.5SYP, VIP, S100B, NPY
46estrogen458.4NPY, VIP, SYP, S100B
47catecholamine458.2SYP, VIP, S100B, MYCN, NPY
48dopamine45 29 24 1111.2NPY, S100B, SYP, MYCN, VIP
49nitric oxide45 24 1110.2S100B, SYP, NPY, VIP, MYCN
50tyrosine458.1MYCN, NPY, S100B, SYP, VIP

GO Terms for genes affiliated with Ganglioneuroblastoma

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16Gene Ontology
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Biological processes related to Ganglioneuroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of cell shapeGO:0083609.4S100B, WASF3
2learning or memoryGO:0076119.2S100B, VIP
3regulation of neuronal synaptic plasticityGO:0481689.1S100B, SYP

Molecular functions related to Ganglioneuroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.4NPY, VIP

Products for genes affiliated with Ganglioneuroblastoma

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  • Antibodies
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Sources for Ganglioneuroblastoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet