MCID: GNG008
MIFTS: 53

Ganglioneuroblastoma malady

Neuronal diseases, Cancer diseases categories

Summaries for Ganglioneuroblastoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Ganglioneuroblastoma is a variant of neuroblastoma that is surrounded by ganglion cells. more...

MalaCards: Ganglioneuroblastoma is related to neuroblastoma and ganglioneuroma. An important gene associated with Ganglioneuroblastoma is MYCN (v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog), and among its related pathways are Neuroscience and Signaling by GPCR. The compounds glutamate and creatinine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, adrenal gland and bone, and related mouse phenotypes are respiratory system and muscle.

Aliases & Classifications for Ganglioneuroblastoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
ganglioneuroblastoma:
Inheritance: Sporadic; Age of onset: Childhood


Aliases & Descriptions:

ganglioneuroblastoma 8 10 44 48 60


External Ids:

Disease Ontology8 DOID:4163
NCIt39 C3790
SNOMED-CT56 69515008
MeSH34 D018305
SNOMED-CT via Orphanet57 69515008

Related Diseases for Ganglioneuroblastoma

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17GeneCards, 18GeneDecks
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Diseases related to Ganglioneuroblastoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 185)
idRelated DiseaseScoreTop Affiliating Genes
1neuroblastoma30.9VIP, SYP, NTRK1, MYCN, TH, ENO2
2ganglioneuroma30.6MYCN, NTRK1, CHGA, SYP, CD44, NPY
3diarrhea30.5TOP1, CHGA, VIP
4pheochromocytoma30.4NPY, VIP, ADM, ENO2, TH, HCRT
5hypokalemia30.0VIP
6adrenal neuroblastoma30.0MYCN
7hypertension30.0NPY, TH, ADM
8phaeochromocytoma30.0NPY, CHGA, ADM
9cushing's syndrome30.0NPY, SYP, CHGA
10paraganglioma30.0ENO2, SYP, S100B, TH, CHGA
11hepatitis29.8MYCN
12constipation29.8VIP
13gangliocytoma29.8SYP
14neurofibroma29.8S100B, SYP
15adrenocortical carcinoma29.8CHGA, VIP, SYP, ADM
16vipoma29.8VIP, CHGA
17adenoma29.8ENO2, SYP, CHGA, NTRK1, CD44
18ganglioglioma29.8NTRK1, TH, CHGA, SYP, S100B, ENO2
19leukemia29.8NTRK1, CD44, ABCB1, MYCN, DLL1, TOP1
20nodular ganglioneuroblastoma10.3
21mediastinum ganglioneuroblastoma10.3
22adrenal gland ganglioneuroblastoma10.3
23hirschsprung disease ganglioneuroblastoma10.3
24peripheral nervous system ganglioneuroblastoma10.2
25mediastinitis10.2
26syndromic diarrhea10.2
27neuronitis10.2
28cerebritis10.1
29differentiating neuroblastoma10.1
30cervicitis10.1
31neurofibromatosis10.0
32intermixed schwannian stroma-rich ganglioneuroblastoma10.0
33functional diarrhea10.0
34osteomalacia10.0
35stroma-dominant and stroma-poor composite ganglioneuroblastoma10.0
36schwannian stroma-rich and stroma-poor composite ganglioneuroblastoma10.0
37turner syndrome10.0
38rhabdoid tumor10.0SYP
39von hippel-lindau disease10.0NPY
40dysembryoplastic neuroepithelial tumor10.0SYP
41thymoma10.0NTRK1
42alcohol dependence10.0NPY
43primary hyperoxaluria10.0CD44
44oligodendroglioma10.0SYP
45cerebral primitive neuroectodermal tumor10.0MYCN
46papilloma10.0MYCN
47epulis10.0ENO2
48tuberous sclerosis10.0S100B, SYP
49leishmaniasis10.0TOP1
50leiomyosarcoma10.0ENO2, S100B

Graphical network of the top 20 diseases related to Ganglioneuroblastoma:



Diseases related to ganglioneuroblastoma

Clinical Features for Ganglioneuroblastoma

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Drugs & Therapeutics for Ganglioneuroblastoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Ganglioneuroblastoma

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Anatomical Context for Ganglioneuroblastoma

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32MalaCards
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MalaCards organs/tissues related to Ganglioneuroblastoma:

32
Spinal cord, Adrenal gland, Bone, Brain, Bone marrow, Cerebellum, Kidney, Pineal, Myeloid, Lung, Colon, Thymus, Lymph node, Pituitary

Animal Models for Ganglioneuroblastoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Ganglioneuroblastoma:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053889.3VIP, MYCN, HCRT, CD44, TH, ENO2
2MP:00053699.2NTRK1, MYCN, HCRT, DLL1, DLK1
3MP:00053679.2CHGA, MYCN, CD44, DLL1, ADM, NPY
4MP:00053709.0NPY, MYCN, CD44, DLK1, ABCB1, TH
5MP:00028738.7SYP, NPY, S100B, VIP, NTRK1, CBLN3
6MP:00053768.5GALP, NPY, HTR1A, VIP, MYCN, HCRT
7MP:00053858.2VIP, HTR1A, CHGA, MYCN, HCRT, CD44
8MP:00036318.0CBLN3, NTRK1, SYP, NPY, HTR1A, MYCN
9MP:00053788.0NPY, GALP, CHGA, NTRK1, MYCN, HCRT
10MP:00107687.9NTRK1, CHGA, TOP1, HTR1A, VIP, MYCN
11MP:00053867.5ADM, VIP, S100B, HTR1A, NPY, GALP

Publications for Ganglioneuroblastoma

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50PubMed
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Articles related to Ganglioneuroblastoma:

(show top 50)    (show all 207)
idTitleAuthorsYear
1
Ganglioneuroblastoma in a young child with Turner syndrome. (23155714)
2012
2
Characteristics and outcome of patients with ganglioneuroblastoma, nodular subtype: a report from the INRG project. (22137163)
2012
3
Simultaneous tumors: acute myeloid leukemia infiltrating mediastinal ganglioneuroblastoma. (20973101)
2011
4
Diffusion-weighted MRI for differentiation of neuroblastoma and ganglioneuroblastoma/ganglioneuroma. (20462716)
2011
5
A composite pheochromocytoma/ganglioneuroblastoma of the adrenal gland. (20162688)
2010
6
Life-threatening complications of an extremely rare tumor of the kidney: adult-type primary renal ganglioneuroblastoma. (17713319)
2007
7
Metastatic ganglioneuroblastoma in head and neck diagnosed by fine needle aspiration: a case report. (17536548)
2007
8
A rare ganglioneuroblastoma secreting dopamine and the value of its measurement in diagnosis and prognosis. (16390613)
2006
9
Adult-type ganglioneuroblastoma in the adrenal gland treated by a laparoscopic resection: report of a case. (14513331)
2003
10
Revision of the International Neuroblastoma Pathology Classification: confirmation of favorable and unfavorable prognostic subsets in ganglioneuroblastoma, nodular. (14601099)
2003
11
Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: radiologic-pathologic correlation. (12110723)
2002
12
WAVE3, an actin-polymerization gene, is truncated and inactivated as a result of a constitutional t(1;13)(q21;q12) chromosome translocation in a patient with ganglioneuroblastoma. (12185600)
2002
13
Adrenal ganglioneuroblastoma in pregnant woman: diagnosis with three-dimensional ultrasound. (12522620)
2002
14
Expression of melanin-concentrating hormone receptor messenger ribonucleic acid in tumor tissues of pheochromocytoma, ganglioneuroblastoma, and neuroblastoma. (11232026)
2001
15
Ganglioneuroblastoma of the cauda equina. (10912210)
2000
16
Pineal ganglioneuroblastoma in an adult. (10619501)
1999
17
Synchronous occurrence of Wilms tumor and ganglioneuroblastoma in a child with neurofibromatosis. (9402494)
1997
18
Ganglioneuroblastoma of the thymus: an adult case with the syndrome of inappropriate secretion of antidiuretic hormone. (8621190)
1996
19
Ganglioneuroblastoma of the spinal cord. (7611061)
1995
20
An immunohistochemical study of peripheral neuroblastoma, ganglioneuroblastoma, anaplastic ganglioglioma, schwannoma and neurofibroma in cattle. (7962722)
1994
21
Thoracic ganglioneuroblastoma in a dog. (7863591)
1994
22
Olfactory ganglioneuroblastoma in a dog: a light, ultrastructural, and immunohistochemical study. (8203095)
1994
23
Pathologic quiz case 1. Cervical ganglioneuroblastoma. (8318213)
1993
24
Adrenocorticotropic hormone-secreting ganglioneuroblastoma associated with opsomyoclonic encephalopathy: a case report with immunohistochemical study. (8413006)
1993
25
Pigmented ganglioneuroblastoma: a tumour cell 'storage disease'? (8354492)
1993
26
An adrenaline-secreting ganglioneuroblastoma with elevated urinary HMMA but normal metanephrine excretion. (1489167)
1992
27
Posterior mediastinal masses in children: ganglioneuroblastoma. (1543100)
1992
28
Hormone-producing ganglioneuroblastoma simulating intestinal pseudoobstruction. (2308033)
1990
29
Primary renal ganglioneuroblastoma in an adult. (2099436)
1990
30
Identification of 5-HT1A recognition sites in human ganglioneuroblastoma. (2575526)
1989
31
Bilateral adrenal ganglioneuroblastoma with neuromelanin. Clinical and pathologic observations. (3277701)
1988
32
Lumbar dumbbell ganglioneuroblastoma: a light and electron microscopic study of neuronal degeneration. (3251147)
1988
33
Multifocal ganglioneuroblastoma coexistent with total colonic aganglionosis. (3351729)
1988
34
A disseminated ganglioneuroblastoma in a 31-year-old woman. (3587461)
1987
35
Expression of neurofilament triplet proteins in human neural tumors. An immunohistochemical study of paraganglioma, ganglioneuroma, ganglioneuroblastoma, and neuroblastoma. (3079958)
1986
36
Primary small bowel ganglioneuroblastoma and Friedreich's ataxia. (3783549)
1986
37
Incidental ganglioneuroblastoma. (3952916)
1986
38
Case report 263: neuroblastoma (or poorly differentiated ganglioneuroblastoma) arising from the left tenth rib and probably involving the left ninth rib. (6701552)
1984
39
Extraosseous localization of 99mTc-MDP in ganglioneuroblastoma. (6214400)
1982
40
Case report. Computer assisted tomographic evaluation of a ganglioneuroblastoma in an adult. (422782)
1979
41
Ganglioneuroblastoma: a case report. (500172)
1979
42
Asymptomatic thoracic ganglioneuroblastoma with spinal cord compression. (616802)
1977
43
Pigmented ganglioneuroblastoma: relation of melanin and lipofuscin to schwannomas and other tumors of neural crest origin. (180265)
1976
44
Biochemical differentiation of a murine ganglioneuroblastoma in tissue culture. (4616838)
1974
45
The catecholamines in tumor and urine from patients with neuroblastoma, ganglioneuroblastoma and pheochromocytoma. (5655562)
1968
46
Cystathioninuria in patients with neuroblastoma or ganglioneuroblastoma. Its correlation to vanilmandelic acid excretion and its value in diagnosis and therapy. (5212308)
1968
47
Ganglioneuroblastoma of the cerebellum. Case report. (5643919)
1968
48
THE ULTRASTRUCTURE OF GANGLIONEUROBLASTOMA. OBSERVATIONS ON NEOPLASTIC GANGLION CELLS. (14262322)
1965
49
Catecholamines and diarrhea in ganglioneuroblastoma. (13984152)
1962
50
Multiple tumors of the sympathetic nervous system: Report of a case showing a distinct ganglioneuroma, a neuroblastoma and a cystic calcifying ganglioneuroblastoma. (19970419)
1938

Genetic Variations for Ganglioneuroblastoma

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Expression for genes affiliated with Ganglioneuroblastoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ganglioneuroblastoma

Search GEO for disease gene expression data for Ganglioneuroblastoma.

Pathways for genes affiliated with Ganglioneuroblastoma

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4Cell Signaling Technology, 53Reactome
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Pathways related to Ganglioneuroblastoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
18.9ENO2, S100B, HTR1A, NPY, SYP, NTRK1
2
Hide members
8.5S100B, HTR1A, NPY, NTRK1, HCRT, DLL1

Compounds for genes affiliated with Ganglioneuroblastoma

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44Novoseek, 59Tocris Bioscience, 24HMDB, 49PharmGKB, 11DrugBank, 28IUPHAR, 2BitterDB
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Compounds related to Ganglioneuroblastoma according to GeneCards/GeneDecks:

(show top 50)    (show all 152)
idCompoundScoreTop Affiliating Genes
1glutamate4410.2NPY, HCRT, NTRK1
2creatinine4410.0SYP, NPY, NTRK1, CHGA
3s 100449.9S100B, CHGA, SYP, ENO2
4oxyntomodulin44 5910.9HCRT, CHGA, NPY, VIP
5galp449.9NPY, HCRT, GALP
6homovanillic acid44 2410.8CHGA, MYCN, ENO2, TH
7vanillylmandelic acid44 2410.8CHGA, MYCN, VIP, TH, ENO2
8smcc449.8ENO2, CHGA, SYP
9forskolin44 49 1111.8NPY, ADM, ENO2, TH, GALP
10l-amino acid449.8S100B, TH, CHGA, ENO2, SYP
11tetrodotoxin44 59 2811.7TH, ENO2, HCRT, NPY, VIP
12mibg449.7ENO2, ADM, VIP, TH, CHGA
13etoposide44 49 59 1112.7TOP1, CHGA, CD44, ABCB1, MYCN, S100B
14dbc-amp449.7ADM, VIP, SYP, ENO2, MYCN, S100B
15dexamethasone44 49 28 1112.7ENO2, TH, ABCB1, S100B, VIP, HCRT
16sodium nitroprusside449.6ADM, VIP, S100B, NPY, TH
17propranolol44 28 49 11 2413.6VIP, HTR1A, CHGA, ABCB1, ADM
18carbachol44 28 1111.5VIP, TH, NPY, CHGA, HCRT, ADM
19choline44 11 2411.5NPY, S100B, VIP, SYP, NTRK1, TH
20carboplatin44 49 1111.5TOP1, ENO2, ABCB1, CHGA, CD44
21gnrh449.4GALP, CHGA, VIP, TH, CD44, NTRK1
22histamine44 28 2411.3HCRT, VIP, NPY, SYP, TH, ADM
23p003449.3CHGA, CD44, ADM, NTRK1, S100B
24glutamine449.3VIP, S100B, NPY, TOP1, TH, ENO2
25corticosterone44 59 2411.3NPY, VIP, CBLN3, HCRT, HTR1A, TH
26guanine44 11 2411.3VIP, HTR1A, CHGA, TOP1, SYP, ENO2
27potassium44 11 2411.2SYP, NTRK1, ENO2, VIP, ADM, S100B
28haloperidol44 28 2 49 1113.2SYP, HCRT, ABCB1, TH, NPY, HTR1A
29formaldehyde44 2410.2NPY, CD44, CHGA, SYP, TOP1, S100B
30gaba449.2HCRT, CHGA, NPY, VIP, TH, ENO2
31glucose449.2HCRT, GALP, ADM, DLK1, NPY, CD44
325-hydroxytryptamine449.1VIP, HTR1A, SYP, CHGA, HCRT, TH
33acetylcholine44 49 28 11 2413.1ADM, CHGA, SYP, ENO2, TH, HCRT
34dopamine44 28 11 2412.0MYCN, HCRT, ENO2, TH, CHGA, NPY
35progesterone44 59 28 11 2413.0SYP, NTRK1, CD44, CHGA, ENO2, ABCB1
36alanine448.9NTRK1, NPY, TH, HCRT, CD44, ADM
37acth448.9HCRT, CHGA, ADM, SYP, NPY, HTR1A
38epinephrine44 11 2410.9VIP, NPY, CHGA, CBLN3, ABCB1, CD44
39paraffin448.9S100B, CHGA, SYP, ADM, ENO2, TH
40lactate448.9ADM, ENO2, TH, CD44, VIP, MYCN
41vegf448.8S100B, SYP, ADM, ENO2, TH, CD44
42retinoic acid44 249.8ENO2, NPY, S100B, CHGA, NTRK1, MYCN
43cisplatin44 49 59 1111.7ABCB1, ENO2, TOP1, SYP, CHGA, MYCN
44nitric oxide44 11 2410.6HCRT, NPY, ADM, S100B, VIP, MYCN
45cyclic amp44 249.6NPY, DLK1, CD44, HCRT, NTRK1, CHGA
46adenylate448.5VIP, NPY, CHGA, NTRK1, HCRT, CD44
47norepinephrine44 11 2410.4ENO2, ADM, VIP, S100B, HTR1A, NPY
48testosterone44 59 11 2411.4CD44, VIP, S100B, NPY, NTRK1, CHGA
49catecholamine448.4CHGA, NTRK1, MYCN, HCRT, TH, ENO2
50tyrosine448.1VIP, CHGA, SYP, NPY, S100B, ADM

GO Terms for genes affiliated with Ganglioneuroblastoma

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16Gene Ontology
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Cellular components related to Ganglioneuroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmic vesicleGO:0314109.9TH, DLL1, NTRK1
2perikaryonGO:0432049.7ENO2, TH, TOP1
3extracellular regionGO:0055768.5VIP, S100B, NPY, GALP, CHGA, HCRT

Biological processes related to Ganglioneuroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular response to nicotineGO:07131610.1TH, NTRK1
2response to nutrient levelsGO:03166710.1TH, NTRK1
3learning or memoryGO:00761110.0NTRK1, S100B, VIP
4negative regulation of potassium ion transportGO:04326710.0VIP, HCRT
5neuropeptide signaling pathwayGO:0072189.6HCRT, GALP, NPY

Molecular functions related to Ganglioneuroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.8ADM, GALP, VIP

Products for genes affiliated with Ganglioneuroblastoma

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  • Antibodies
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Sources for Ganglioneuroblastoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet