MCID: GNG008
MIFTS: 44

Ganglioneuroblastoma

Categories: Neuronal diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Ganglioneuroblastoma

MalaCards integrated aliases for Ganglioneuroblastoma:

Name: Ganglioneuroblastoma 12 55 28 51 41 14 69

Characteristics:

Orphanet epidemiological data:

55
ganglioneuroblastoma
Inheritance: Not applicable; Age of onset: Childhood,Infancy;

Classifications:

Orphanet: 55  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:4163
MeSH 41 D018305
NCIt 46 C3790
Orphanet 55 ORPHA251877
UMLS via Orphanet 70 C0206718
ICD10 via Orphanet 33 C71.9
UMLS 69 C0206718

Summaries for Ganglioneuroblastoma

MalaCards based summary : Ganglioneuroblastoma is related to nodular ganglioneuroblastoma and cystic teratoma. An important gene associated with Ganglioneuroblastoma is WASF3 (WAS Protein Family Member 3), and among its related pathways/superpathways are Neuroscience and Alzheimers Disease Pathway. The drugs Isotretinoin and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include brain, adrenal gland and spinal cord, and related phenotypes are behavior/neurological and nervous system

Wikipedia : 72 Ganglioneuroblastoma is a variant of neuroblastoma that is surrounded by ganglion... more...

Related Diseases for Ganglioneuroblastoma

Diseases related to Ganglioneuroblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 180)
# Related Disease Score Top Affiliating Genes
1 nodular ganglioneuroblastoma 32.7 ENO2 MYCN NTRK2
2 cystic teratoma 29.2 ENO2 SYP
3 ganglioglioma 29.0 ENO2 SYP
4 pheochromocytoma 28.5 ENO2 NPY NTRK1 SYP VIP
5 hirschsprung disease 1 28.2 ENO2 NPY SYP VIP
6 ganglioneuroma 28.0 ENO2 GALP MYCN NTRK1 NTRK2 SYP
7 neuroblastoma 28.0 ENO2 MYCN NPY NTRK1 NTRK2 SYP
8 hirschsprung disease ganglioneuroblastoma 11.9
9 peripheral nervous system ganglioneuroblastoma 11.9
10 mediastinum ganglioneuroblastoma 11.9
11 adrenal gland ganglioneuroblastoma 11.9
12 intermixed schwannian stroma-rich ganglioneuroblastoma 11.8
13 stroma-dominant and stroma-poor composite ganglioneuroblastoma 11.8
14 schwannian stroma-rich and stroma-poor composite ganglioneuroblastoma 11.8
15 cervical neuroblastoma 10.2 MYCN VIP
16 extracranial neuroblastoma 10.2 MYCN VIP
17 leprosy 2 10.2 NPY VIP
18 intermittent explosive disorder 10.2 HTR1A NPY
19 desmoplastic infantile ganglioglioma 10.2 MYCN SYP
20 diarrhea 10.2
21 hereditary sensory neuropathy 10.1 NTRK1 NTRK2
22 binswanger's disease 10.0 SYP VIP
23 adrenal neuroblastoma 10.0 ENO2 MYCN
24 ataxia and polyneuropathy, adult-onset 10.0
25 cervicitis 10.0
26 mediastinitis 10.0
27 cerebritis 10.0
28 neuronitis 10.0
29 paraneoplastic syndromes 10.0
30 infratentorial cancer 9.9 MYCN SYP
31 somatostatinoma 9.9 ENO2 VIP
32 major depressive disorder 9.9 HTR1A NPY NTRK2
33 bone ewing's sarcoma 9.9 ENO2 MYCN
34 malignant sertoli cell tumor 9.9 ENO2 SYP
35 urinary bladder small cell neuroendocrine carcinoma 9.9 ENO2 SYP
36 pericardium cancer 9.9 ENO2 MYCN
37 sinonasal undifferentiated carcinoma 9.9 ENO2 SYP
38 auditory system cancer 9.9 ENO2 SYP
39 cutaneous ganglioneuroma 9.9 ENO2 SYP
40 sensory organ benign neoplasm 9.9 ENO2 SYP
41 middle ear adenoma 9.9 ENO2 SYP
42 gallbladder small cell carcinoma 9.9 ENO2 SYP
43 pancreatic somatostatinoma 9.9 ENO2 SYP
44 extrahepatic bile duct adenocarcinoma 9.9 ENO2 SYP
45 small cell carcinoma of the bladder 9.9 ENO2 SYP
46 papillary tumor of the pineal region 9.9 ENO2 SYP
47 orbital cancer 9.9 ENO2 SYP
48 ovarian carcinosarcoma 9.9 ENO2 SYP
49 pulmonary large cell neuroendocrine carcinoma 9.9 ENO2 SYP
50 atypical follicular adenoma 9.9 ENO2 SYP

Graphical network of the top 20 diseases related to Ganglioneuroblastoma:



Diseases related to Ganglioneuroblastoma

Symptoms & Phenotypes for Ganglioneuroblastoma

MGI Mouse Phenotypes related to Ganglioneuroblastoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.81 ENO2 GALP HTR1A MYCN NPY NTRK1
2 nervous system MP:0003631 9.5 ENO2 HTR1A MYCN NPY NTRK1 NTRK2
3 normal MP:0002873 9.1 MYCN NPY NTRK1 NTRK2 SYP VIP

Drugs & Therapeutics for Ganglioneuroblastoma

Drugs for Ganglioneuroblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 63)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Isotretinoin Approved Phase 3 4759-48-2 5282379 5538
2
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
3
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
4
Etoposide Approved Phase 3 33419-42-0 36462
5
Busulfan Approved, Investigational Phase 3 55-98-1 2478
6
Cisplatin Approved Phase 3 15663-27-1 2767 441203 84093
7
Iodine Approved, Investigational Phase 3 7553-56-2 807
8
Mechlorethamine Approved, Investigational Phase 3 51-75-2 4033
9
Melphalan Approved Phase 3 148-82-3 460612 4053
10
Topotecan Approved, Investigational Phase 3 119413-54-6, 123948-87-8 60700
11
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
12
Carboplatin Approved Phase 3 41575-94-4 10339178 38904 498142
13
Aldesleukin Approved Phase 3 110942-02-4, 85898-30-2
14
Crizotinib Approved Phase 3 877399-52-5 11626560 10366136 10366137 10366138 10366139 10366140 10366141
15 Thiotepa Approved, Investigational Phase 3 52-24-4 5453
16
Tretinoin Approved, Investigational, Nutraceutical Phase 3 302-79-4 5538
17
Vitamin A Approved, Nutraceutical, Vet_approved Phase 3 68-26-8, 11103-57-4 445354
18
Doxil Approved June 1999 Phase 3 31703
19 Alkylating Agents Phase 3,Phase 2
20 Anti-Bacterial Agents Phase 3,Phase 2
21 Antibiotics, Antitubercular Phase 3,Phase 2
22 Antineoplastic Agents, Phytogenic Phase 3,Phase 2
23 Antirheumatic Agents Phase 3
24 Etoposide phosphate Phase 3
25 Immunosuppressive Agents Phase 3,Phase 2
26 Topoisomerase Inhibitors Phase 3,Phase 2
27 3-Iodobenzylguanidine Phase 3
28 Antimitotic Agents Phase 3
29 cadexomer iodine Phase 3
30 Dermatologic Agents Phase 3
31 Radiopharmaceuticals Phase 3
32 topoisomerase I inhibitors Phase 3,Phase 2
33 Antibodies Phase 3,Phase 2
34 Antibodies, Monoclonal Phase 3,Phase 2
35 Anti-Infective Agents Phase 3,Phase 2
36 Immunoglobulins Phase 3,Phase 2
37 Analgesics Phase 3
38 Analgesics, Non-Narcotic Phase 3
39 Anti-HIV Agents Phase 3
40 Anti-Retroviral Agents Phase 3
41 Antiviral Agents Phase 3
42 Interleukin-2 Phase 3
43 Keratolytic Agents Phase 3
44 Nitrogen Mustard Compounds Phase 3
45 Peripheral Nervous System Agents Phase 3
46 Protective Agents Phase 3
47 Protein Kinase Inhibitors Phase 3
48 razoxane Phase 3
49 Retinol palmitate Phase 3
50 Vitamins Phase 3

Interventional clinical trials:

(show all 11)

# Name Status NCT ID Phase Drugs
1 European Low and Intermediate Risk Neuroblastoma Protocol Recruiting NCT01728155 Phase 3 chemotherapy
2 Response and Biology-Based Risk Factor-Guided Therapy in Treating Younger Patients With Non-high Risk Neuroblastoma Recruiting NCT02176967 Phase 3 Carboplatin;Etoposide;Cyclophosphamide;Doxorubicin Hydrochloride
3 Iobenguane I-131 or Crizotinib and Standard Therapy in Treating Younger Patients With Newly-Diagnosed High-Risk Neuroblastoma or Ganglioneuroblastoma Not yet recruiting NCT03126916 Phase 3 Busulfan;Carboplatin;Cisplatin;Crizotinib;Cyclophosphamide;Dexrazoxane Hydrochloride;Doxorubicin Hydrochloride;Etoposide Phosphate;Isotretinoin;Melphalan;Thiotepa;Topotecan Hydrochloride;Vincristine Sulfate
4 Irinotecan Hydrochloride and Temozolomide With Temsirolimus or Dinutuximab in Treating Younger Patients With Refractory or Relapsed Neuroblastoma Active, not recruiting NCT01767194 Phase 2 Irinotecan Hydrochloride;Temozolomide;Temsirolimus
5 Engineered Neuroblastoma Cellular Immunotherapy (ENCIT)-01 Recruiting NCT02311621 Phase 1
6 Molecularly-Driven Doublet Therapy for Recurrent CNS Malignant Neoplasms Recruiting NCT03434262 Phase 1 Gemcitabine;ribociclib;sonidegib;trametinib
7 Induction Therapy Including 131 I-MIBG and Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma Undergoing Stem Cell Transplant, Radiation Therapy, and Maintenance Therapy With Isotretinoin Completed NCT01175356 cyclophosphamide;topotecan hydrochloride;cisplatin;etoposide phosphate;vincristine sulfate;doxorubicin hydrochloride;busulfan;melphalan;isotretinoin
8 Biomarkers in Tumor Tissue Samples From Patients With Newly Diagnosed Neuroblastoma or Ganglioneuroblastoma Recruiting NCT00904241
9 Phase II Study of Proton Radiation Therapy for Neuroblastoma Recruiting NCT02112617
10 Prospective Study Registry of Peripheral Neuroblastic Tumours Presenting With Spinal Canal Involvement (SCI) Recruiting NCT02559804
11 International Congenital Central Hypoventilation Syndrome (CCHS) Registry Recruiting NCT03088020

Search NIH Clinical Center for Ganglioneuroblastoma

Cochrane evidence based reviews: ganglioneuroblastoma

Genetic Tests for Ganglioneuroblastoma

Genetic tests related to Ganglioneuroblastoma:

# Genetic test Affiliating Genes
1 Ganglioneuroblastoma 28

Anatomical Context for Ganglioneuroblastoma

MalaCards organs/tissues related to Ganglioneuroblastoma:

38
Brain, Adrenal Gland, Spinal Cord, Bone, Lung, Bone Marrow, Kidney

Publications for Ganglioneuroblastoma

Articles related to Ganglioneuroblastoma:

(show top 50) (show all 243)
# Title Authors Year
1
Characteristics and management of ganglioneuroma and ganglioneuroblastoma-intermixed in children and adolescents. ( 29369484 )
2018
2
Clinical and biological features of neuroblastic tumors: A comparison of neuroblastoma and ganglioneuroblastoma. ( 28465480 )
2017
3
Surgical management and outcomes of ganglioneuroma and ganglioneuroblastoma-intermixed. ( 28608056 )
2017
4
Ganglioneuroblastoma in a newborn with multiple metastases: a case report. ( 28847309 )
2017
5
Hitherto unseen survival in an ALK-positive-patient with advanced stage adult ganglioneuroblastoma treated with personalized medicine. ( 29225862 )
2017
6
Adult hippocampal ganglioneuroblastoma: Case report and literature review. ( 29390424 )
2017
7
Adrenal ganglioneuroblastoma in an adult. ( 28922691 )
2017
8
Ganglioneuroblastoma Arising in an Ovarian Dermoid Cyst: First Report in the Literature. ( 28914675 )
2017
9
A case report of the first ganglioneuroblastoma of the parotid gland of an the adult. ( 28630389 )
2017
10
Adrenal Ganglioneuroblastoma in Adults: A Case Report and Review of the Literature. ( 28713603 )
2017
11
Expression of Extracellular Signal-regulated Kinase 5 and Ankyrin Repeat Domain 1 in Composite Pheochromocytoma and Ganglioneuroblastoma Detected Incidentally in the Adult Adrenal Gland. ( 27980262 )
2016
12
A Rare Tumor in the Cervical Sympathetic Trunk: Ganglioneuroblastoma. ( 27965907 )
2016
13
Role of radiotherapy in adult ganglioneuroblastoma and ganglioneuroma. ( 27569100 )
2016
14
Ganglioneuroblastoma during pregnancy--A rare case report. ( 27132425 )
2016
15
A rare case of Ganglioneuroblastoma Encapsulated in Pheochromocytoma. ( 27526309 )
2016
16
Ganglioneuroblastoma: Unusual presentation as a pleural mass mimicking mesothelioma. ( 27051110 )
2016
17
Treatment and outcome of Ganglioneuroma and Ganglioneuroblastoma intermixed. ( 27465021 )
2016
18
Intraparenchymal Spinal Cord Ganglioneuroblastoma Originating from the Peripheral Sympathetic Nervous System in a Cat. ( 26799733 )
2016
19
A malignant transformation of a spinal epidural mass from ganglioneuroblastoma to neuroblastoma. ( 25810863 )
2015
20
Primary cervical ganglioneuroblastoma. ( 25921075 )
2015
21
Eosinophilic esophagitis as paraneoplastic syndrome in a patient with ganglioneuroblastoma. ( 25985452 )
2015
22
Ganglioneuroblastoma of Skull Base. ( 26435974 )
2015
23
Adult adrenal ganglioneuroblastoma: A rare case report. ( 25737766 )
2015
24
Adult onset of ganglioneuroblastoma of the adrenal gland: case report and review of the literature. ( 26380803 )
2015
25
Onset of adrenal ganglioneuroblastoma in an adult after delivery. ( 26448921 )
2015
26
The neuroblastoma and ganglion components of nodular ganglioneuroblastoma are genetically similar: evidence against separate clonal origins. ( 25081755 )
2014
27
Ganglioneuroblastoma of filum terminale: case report. ( 24878272 )
2014
28
Ventricular ganglioneuroblastoma in an adult and successful treatment with radiotherapy. ( 25207191 )
2014
29
Review of our experience with neuroblastoma and ganglioneuroblastoma in adults. ( 25002244 )
2014
30
Pediatric cerebral ganglioneuroblastoma. ( 25216629 )
2014
31
Primary extradural spinal ganglioneuroblastoma: a case report. ( 24831370 )
2014
32
Anti-Hu-associated brainstem encephalitis with ganglioneuroblastoma in a young adult. ( 25099509 )
2014
33
First reported case of ganglioneuroblastoma in pregnancy and a review of the literature. ( 27512439 )
2014
34
Transformation of Merkel cell carcinoma to ganglioneuroblastoma in intracranial metastasis. ( 24996688 )
2014
35
Approach to one lung ventilation during the surgical resection of an intrathoracic ganglioneuroblastoma in a three-year-old child: a case report and review of the literature. ( 24988827 )
2014
36
Giant thoracoabdominal ganglioneuroblastoma in a 17-year-old patient. ( 24887835 )
2013
37
Recurrent multiple spinal paragangliomas as a manifestation of a metastatic composite paraganglioma-ganglioneuroblastoma. ( 23532344 )
2013
38
ERBB3 is a marker of a ganglioneuroblastoma/ganglioneuroma-like expression profile in neuroblastic tumours. ( 23835063 )
2013
39
Ganglioneuroblastoma arising within a retroperitoneal mature cystic teratoma. ( 23293755 )
2012
40
High anaplastic lymphoma kinase immunohistochemical staining in neuroblastoma and ganglioneuroblastoma is an independent predictor of poor outcome. ( 22203052 )
2012
41
Primary intraspinal ganglioneuroblastoma of the thoracic spine: a rare case report. ( 23455798 )
2012
42
Incidental diagnosis of thoracic ganglioneuroblastoma in a 3-year-old female with wheezing. ( 22978059 )
2012
43
Ganglioneuroblastoma in a young child with Turner syndrome. ( 23155714 )
2012
44
Characteristics and outcome of patients with ganglioneuroblastoma, nodular subtype: a report from the INRG project. ( 22137163 )
2012
45
Ganglioneuroblastoma, intermixed with opsoclonus-myoclonus syndrome. ( 22631586 )
2012
46
Large mediastinal nodular ganglioneuroblastoma in a child from Africa. ( 23080230 )
2012
47
Cerebral ganglioneuroblastoma of adult onset: two patients and a review of the literature. ( 22510501 )
2012
48
Lytic and sclerotic (mixed) vertebral metastasis in ganglioneuroblastoma. ( 23723589 )
2012
49
Treatment of severe thoracolumbar kyphoscoliosis on the ground of ganglioneuroblastoma of the diaphragm: a case report. ( 21527857 )
2012
50
Ganglioneuroblastoma masquerading as a traumatic lumbar artery injury and hematoma. ( 22273290 )
2012

Variations for Ganglioneuroblastoma

Expression for Ganglioneuroblastoma

Search GEO for disease gene expression data for Ganglioneuroblastoma.

Pathways for Ganglioneuroblastoma

Pathways related to Ganglioneuroblastoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.76 ENO2 HTR1A MYCN NPY NTRK1 NTRK2
2 10.81 NTRK1 NTRK2
3
Show member pathways
10 NTRK1 NTRK2

GO Terms for Ganglioneuroblastoma

Biological processes related to Ganglioneuroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.67 HTR1A MYCN NTRK2 VIP
2 feeding behavior GO:0007631 9.4 NPY NTRK2
3 central nervous system neuron development GO:0021954 9.32 NPY NTRK2
4 behavior GO:0007610 9.26 HTR1A NPY
5 regulation of appetite GO:0032098 9.16 GALP NPY
6 mechanoreceptor differentiation GO:0042490 8.96 NTRK1 NTRK2
7 neurotrophin signaling pathway GO:0038179 8.62 NTRK1 NTRK2

Molecular functions related to Ganglioneuroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.33 GALP NPY VIP
2 neuropeptide hormone activity GO:0005184 9.26 NPY VIP
3 neurotrophin binding GO:0043121 8.96 NTRK1 NTRK2
4 neurotrophin receptor activity GO:0005030 8.62 NTRK1 NTRK2

Sources for Ganglioneuroblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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