MCID: GNG008
MIFTS: 40

Ganglioneuroblastoma malady

Categories: Neuronal diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Ganglioneuroblastoma

Aliases & Descriptions for Ganglioneuroblastoma:

Name: Ganglioneuroblastoma 12 56 29 52 42 14 69

Characteristics:

Orphanet epidemiological data:

56
ganglioneuroblastoma
Inheritance: Not applicable; Age of onset: Childhood,Infancy;

Classifications:

Orphanet: 56  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:4163
MeSH 42 D018305
NCIt 47 C3790
Orphanet 56 ORPHA251877
UMLS via Orphanet 70 C0206718
UMLS 69 C0206718

Summaries for Ganglioneuroblastoma

MalaCards based summary : Ganglioneuroblastoma is related to pheochromocytoma and neuroblastoma. An important gene associated with Ganglioneuroblastoma is WASF3 (WAS Protein Family Member 3), and among its related pathways/superpathways are Neuroscience and Alzheimers Disease Pathway. The drugs Isotretinoin and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, adrenal gland and bone, and related phenotype is behavior/neurological.

Wikipedia : 71 Ganglioneuroblastoma is a variant of neuroblastoma that is surrounded by ganglion... more...

Related Diseases for Ganglioneuroblastoma

Diseases related to Ganglioneuroblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 135)
id Related Disease Score Top Affiliating Genes
1 pheochromocytoma 29.5 ENO2 NTRK1 SYP VIP
2 neuroblastoma 29.5 ENO2 MYCN NTRK1 NTRK2 SYP VIP
3 nodular ganglioneuroblastoma 11.9
4 hirschsprung disease ganglioneuroblastoma 11.8
5 peripheral nervous system ganglioneuroblastoma 11.8
6 mediastinum ganglioneuroblastoma 11.8
7 adrenal gland ganglioneuroblastoma 11.8
8 intermixed schwannian stroma-rich ganglioneuroblastoma 11.7
9 stroma-dominant and stroma-poor composite ganglioneuroblastoma 11.7
10 schwannian stroma-rich and stroma-poor composite ganglioneuroblastoma 11.7
11 auriculocondylar syndrome 1 10.2 NTRK1 NTRK2
12 walker-warburg syndrome 10.2 NTRK1 NTRK2
13 gall bladder carcinoma in situ 10.2 MYCN NTRK1
14 ganglioneuroma 10.2
15 peripheral osteosarcoma 10.1 ENO2 MYCN
16 uterine corpus endometrial carcinoma 10.1 MYCN VIP
17 mucinous stomach adenocarcinoma 10.1 MYCN VIP
18 barre-lieou syndrome 10.1 NTRK2 SYP
19 spinal stenosis 10.1 ENO2 VIP
20 hyperandrogenism 10.1 ENO2 MYCN
21 diarrhea 10.1
22 pancreatic agenesis 10.0 NTRK2 SYP
23 lipid-rich carcinoma 10.0 ENO2 VIP
24 diabetes hypogonadism deafness mental retardation 10.0 MYCN SYP
25 infiltrating renal pelvis transitional cell carcinoma 10.0 ENO2 SYP
26 thymus small cell carcinoma 10.0 ENO2 SYP
27 skeletal-extraskeletal angiomatosis 10.0 ENO2 SYP
28 urinary tract obstruction 10.0 ENO2 MYCN NTRK2
29 prolactin producing pituitary tumor 10.0 ENO2 SYP
30 glomus tumor 10.0 ENO2 SYP
31 pemphigus foliaceus 10.0 ENO2 SYP
32 spasmodic dysphonia 10.0 ENO2 SYP
33 autosomal recessive stickler syndrome 10.0 ENO2 SYP
34 ampullary signet ring cell adenocarcinoma 10.0 ENO2 SYP
35 nephrogenic adenoma of urinary bladder 10.0 ENO2 SYP
36 perineural angioma 10.0 ENO2 SYP
37 blood group incompatibility 10.0 ENO2 SYP
38 gliofibroma 10.0 ENO2 SYP
39 rectum leiomyoma 10.0 ENO2 SYP
40 superior vena cava syndrome 10.0 ENO2 SYP
41 pineoblastoma 10.0 MYCN SYP
42 fragile x-associated tremor/ataxia syndrome 10.0 ENO2 SYP
43 gallbladder pleomorphic giant cell adenocarcinoma 10.0 ENO2 SYP
44 adult epithelioid sarcoma 10.0 ENO2 SYP
45 piussan lenaerts mathieu syndrome 10.0 ENO2 SYP
46 thymoma 10.0 ENO2 SYP
47 anal squamous cell carcinoma 10.0 ENO2 SYP
48 uterine corpus myxoid leiomyosarcoma 10.0 ENO2 SYP
49 thoracic benign neoplasm 10.0 ENO2 SYP
50 microsporidiosis 10.0 ENO2 SYP

Graphical network of the top 20 diseases related to Ganglioneuroblastoma:



Diseases related to Ganglioneuroblastoma

Symptoms & Phenotypes for Ganglioneuroblastoma

MGI Mouse Phenotypes related to Ganglioneuroblastoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.23 ENO2 GALP HTR1A MYCN NTRK1 NTRK2

Drugs & Therapeutics for Ganglioneuroblastoma

Drugs for Ganglioneuroblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 68)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Isotretinoin Approved Phase 3 4759-48-2 5538 5282379
2
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
3
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
4
Etoposide Approved Phase 3 33419-42-0 36462
5
Busulfan Approved, Investigational Phase 3 55-98-1 2478
6
Cisplatin Approved Phase 3 15663-27-1 84093 441203 2767
7
Mechlorethamine Approved Phase 3 51-75-2 4033
8
Melphalan Approved Phase 3 148-82-3 4053 460612
9
Topotecan Approved, Investigational Phase 3 119413-54-6, 123948-87-8 60700
10
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
11
Carboplatin Approved Phase 3 41575-94-4 10339178 498142 38904
12
Aldesleukin Approved Phase 3 85898-30-2, 110942-02-4
13
Crizotinib Approved Phase 3 877399-52-5 11626560 10366136 10366137 10366138 10366139 10366140 10366141
14
Succinylcholine Approved Phase 3 306-40-1 5314
15
Thiotepa Approved Phase 3 52-24-4 5453
16
Tretinoin Approved, Investigational, Nutraceutical Phase 3 302-79-4 5538
17
Vitamin A Approved, Nutraceutical, Vet_approved Phase 3 11103-57-4, 68-26-8 445354
18
Doxil Approved June 1999 Phase 3 31703
19 Alkylating Agents Phase 3,Phase 2
20 Anti-Bacterial Agents Phase 3,Phase 2
21 Antibiotics, Antitubercular Phase 3,Phase 2
22 Antineoplastic Agents, Alkylating Phase 3,Phase 2
23 Antineoplastic Agents, Phytogenic Phase 3,Phase 2
24 Antirheumatic Agents Phase 3
25 Etoposide phosphate Phase 3
26 Immunosuppressive Agents Phase 3,Phase 2
27 Topoisomerase Inhibitors Phase 3,Phase 2
28 3-Iodobenzylguanidine Phase 3
29 Antimitotic Agents Phase 3
30 cadexomer iodine Phase 3
31 Dermatologic Agents Phase 3
32
Iodine Phase 3 7553-56-2 807
33 Radiopharmaceuticals Phase 3
34 topoisomerase I inhibitors Phase 3,Phase 2
35 Analgesics Phase 3
36 Analgesics, Non-Narcotic Phase 3
37 Antibodies Phase 3,Phase 2
38 Antibodies, Monoclonal Phase 3,Phase 2
39 Anti-HIV Agents Phase 3
40 Anti-Infective Agents Phase 3,Phase 2
41 Anti-Retroviral Agents Phase 3
42 Antiviral Agents Phase 3
43 Immunoglobulins Phase 3,Phase 2
44 Interleukin-2 Phase 3
45 Keratolytic Agents Phase 3
46 Neuromuscular Agents Phase 3
47 Neuromuscular Blocking Agents Phase 3
48 Neuromuscular Depolarizing Agents Phase 3
49 Nitrogen Mustard Compounds Phase 3
50 Peripheral Nervous System Agents Phase 3

Interventional clinical trials:


id Name Status NCT ID Phase
1 European Low and Intermediate Risk Neuroblastoma Protocol Recruiting NCT01728155 Phase 3
2 Response and Biology-Based Risk Factor-Guided Therapy in Treating Younger Patients With Non-high Risk Neuroblastoma Recruiting NCT02176967 Phase 3
3 Iobenguane I-131 or Crizotinib and Standard Therapy in Treating Younger Patients With Newly-Diagnosed High-Risk Neuroblastoma or Ganglioneuroblastoma Not yet recruiting NCT03126916 Phase 3
4 Irinotecan Hydrochloride and Temozolomide With Temsirolimus or Dinutuximab in Treating Younger Patients With Refractory or Relapsed Neuroblastoma Suspended NCT01767194 Phase 2
5 Engineered Neuroblastoma Cellular Immunotherapy (ENCIT)-01 Recruiting NCT02311621 Phase 1
6 Induction Therapy Including 131 I-MIBG and Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma Undergoing Stem Cell Transplant, Radiation Therapy, and Maintenance Therapy With Isotretinoin Completed NCT01175356
7 Biomarkers in Tumor Tissue Samples From Patients With Newly Diagnosed Neuroblastoma or Ganglioneuroblastoma Recruiting NCT00904241
8 Phase II Study of Proton Radiation Therapy for Neuroblastoma Recruiting NCT02112617
9 Prospective Study Registry of Peripheral Neuroblastic Tumours Presenting With Spinal Canal Involvement (SCI) Recruiting NCT02559804
10 International Congenital Central Hypoventilation Syndrome (CCHS) Registry Recruiting NCT03088020

Search NIH Clinical Center for Ganglioneuroblastoma

Cochrane evidence based reviews: ganglioneuroblastoma

Genetic Tests for Ganglioneuroblastoma

Genetic tests related to Ganglioneuroblastoma:

id Genetic test Affiliating Genes
1 Ganglioneuroblastoma 29

Anatomical Context for Ganglioneuroblastoma

MalaCards organs/tissues related to Ganglioneuroblastoma:

39
Spinal Cord, Adrenal Gland, Bone, Brain, Lung, Kidney, Bone Marrow

Publications for Ganglioneuroblastoma

Articles related to Ganglioneuroblastoma:

(show top 50) (show all 233)
id Title Authors Year
1
Treatment and outcome of Ganglioneuroma and Ganglioneuroblastoma intermixed. ( 27465021 )
2016
2
Ganglioneuroblastoma: Unusual presentation as a pleural mass mimicking mesothelioma. ( 27051110 )
2016
3
A rare case of Ganglioneuroblastoma Encapsulated in Pheochromocytoma. ( 27526309 )
2016
4
Expression of Extracellular Signal-regulated Kinase 5 and Ankyrin Repeat Domain 1 in Composite Pheochromocytoma and Ganglioneuroblastoma Detected Incidentally in the Adult Adrenal Gland. ( 27980262 )
2016
5
Ganglioneuroblastoma during pregnancy--A rare case report. ( 27132425 )
2016
6
Intraparenchymal Spinal Cord Ganglioneuroblastoma Originating from the Peripheral Sympathetic Nervous System in a Cat. ( 26799733 )
2016
7
Role of radiotherapy in adult ganglioneuroblastoma and ganglioneuroma. ( 27569100 )
2016
8
A Rare Tumor in the Cervical Sympathetic Trunk: Ganglioneuroblastoma. ( 27965907 )
2016
9
Primary cervical ganglioneuroblastoma. ( 25921075 )
2015
10
Eosinophilic esophagitis as paraneoplastic syndrome in a patient with ganglioneuroblastoma. ( 25985452 )
2015
11
Adult adrenal ganglioneuroblastoma: A rare case report. ( 25737766 )
2015
12
Ganglioneuroblastoma of Skull Base. ( 26435974 )
2015
13
Adult onset of ganglioneuroblastoma of the adrenal gland: case report and review of the literature. ( 26380803 )
2015
14
A malignant transformation of a spinal epidural mass from ganglioneuroblastoma to neuroblastoma. ( 25810863 )
2015
15
Onset of adrenal ganglioneuroblastoma in an adult after delivery. ( 26448921 )
2015
16
The neuroblastoma and ganglion components of nodular ganglioneuroblastoma are genetically similar: evidence against separate clonal origins. ( 25081755 )
2014
17
First reported case of ganglioneuroblastoma in pregnancy and a review of the literature. ( 27512439 )
2014
18
Review of our experience with neuroblastoma and ganglioneuroblastoma in adults. ( 25002244 )
2014
19
Anti-Hu-associated brainstem encephalitis with ganglioneuroblastoma in a young adult. ( 25099509 )
2014
20
Approach to one lung ventilation during the surgical resection of an intrathoracic ganglioneuroblastoma in a three-year-old child: a case report and review of the literature. ( 24988827 )
2014
21
Pediatric cerebral ganglioneuroblastoma. ( 25216629 )
2014
22
Primary extradural spinal ganglioneuroblastoma: a case report. ( 24831370 )
2014
23
Ventricular ganglioneuroblastoma in an adult and successful treatment with radiotherapy. ( 25207191 )
2014
24
Transformation of Merkel cell carcinoma to ganglioneuroblastoma in intracranial metastasis. ( 24996688 )
2014
25
Ganglioneuroblastoma of filum terminale: case report. ( 24878272 )
2014
26
ERBB3 is a marker of a ganglioneuroblastoma/ganglioneuroma-like expression profile in neuroblastic tumours. ( 23835063 )
2013
27
Recurrent multiple spinal paragangliomas as a manifestation of a metastatic composite paraganglioma-ganglioneuroblastoma. ( 23532344 )
2013
28
Giant thoracoabdominal ganglioneuroblastoma in a 17-year-old patient. ( 24887835 )
2013
29
Cerebral ganglioneuroblastoma of adult onset: two patients and a review of the literature. ( 22510501 )
2012
30
High anaplastic lymphoma kinase immunohistochemical staining in neuroblastoma and ganglioneuroblastoma is an independent predictor of poor outcome. ( 22203052 )
2012
31
Ganglioneuroblastoma in a young child with Turner syndrome. ( 23155714 )
2012
32
Ganglioneuroblastoma arising within a retroperitoneal mature cystic teratoma. ( 23293755 )
2012
33
Characteristics and outcome of patients with ganglioneuroblastoma, nodular subtype: a report from the INRG project. ( 22137163 )
2012
34
Treatment of severe thoracolumbar kyphoscoliosis on the ground of ganglioneuroblastoma of the diaphragm: a case report. ( 21527857 )
2012
35
Ganglioneuroblastoma, intermixed with opsoclonus-myoclonus syndrome. ( 22631586 )
2012
36
Lytic and sclerotic (mixed) vertebral metastasis in ganglioneuroblastoma. ( 23723589 )
2012
37
Incidental diagnosis of thoracic ganglioneuroblastoma in a 3-year-old female with wheezing. ( 22978059 )
2012
38
Primary intraspinal ganglioneuroblastoma of the thoracic spine: a rare case report. ( 23455798 )
2012
39
A cervicothoracic intramedullary ganglioneuroblastoma presenting with acute quadriparesis. ( 22824708 )
2012
40
Ganglioneuroblastoma of the thoracic spinal cord: a very rare case report. ( 22696937 )
2012
41
Ganglioneuroblastoma masquerading as a traumatic lumbar artery injury and hematoma. ( 22273290 )
2012
42
Large mediastinal nodular ganglioneuroblastoma in a child from Africa. ( 23080230 )
2012
43
Simultaneous tumors: acute myeloid leukemia infiltrating mediastinal ganglioneuroblastoma. ( 20973101 )
2011
44
Ganglioneuroblastoma presenting as a subcutaneous lump diagnosed by fine needle aspiration. ( 21934238 )
2011
45
Mediastinal ganglioneuroblastoma-secreting vasoactive intestinal peptide causing secretory diarrhoea. ( 21684485 )
2011
46
Ganglioneuroblastoma infiltrating the bone marrow in an adult. ( 21496002 )
2011
47
Coexisting of Wilms tumor and ganglioneuroblastoma in a child. ( 21615245 )
2011
48
Ganglioneuroblastoma: Case report and review of the literature. ( 23396255 )
2011
49
Diffusion-weighted MRI for differentiation of neuroblastoma and ganglioneuroblastoma/ganglioneuroma. ( 20462716 )
2011
50
Primary holocord ganglioneuroblastoma: case report. ( 21740125 )
2011

Variations for Ganglioneuroblastoma

Expression for Ganglioneuroblastoma

Search GEO for disease gene expression data for Ganglioneuroblastoma.

Pathways for Ganglioneuroblastoma

Pathways related to Ganglioneuroblastoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.68 ENO2 HTR1A MYCN NTRK1 NTRK2 SYP
2 10.81 NTRK1 NTRK2
3
Show member pathways
10 NTRK1 NTRK2

GO Terms for Ganglioneuroblastoma

Biological processes related to Ganglioneuroblastoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.46 HTR1A MYCN NTRK2 VIP
2 mechanoreceptor differentiation GO:0042490 8.96 NTRK1 NTRK2
3 neurotrophin signaling pathway GO:0038179 8.62 NTRK1 NTRK2

Molecular functions related to Ganglioneuroblastoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.16 NTRK1 NTRK2
2 neurotrophin binding GO:0043121 8.96 NTRK1 NTRK2
3 neurotrophin receptor activity GO:0005030 8.62 NTRK1 NTRK2

Sources for Ganglioneuroblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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