MCID: GNG008
MIFTS: 47

Ganglioneuroblastoma malady

Neuronal diseases, Cancer diseases, Rare diseases categories
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Summaries for Ganglioneuroblastoma

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Wikipedia:65 Ganglioneuroblastoma is a variant of neuroblastoma that is surrounded by ganglion cells. more...

MalaCards based summary: Ganglioneuroblastoma is related to neuroblastoma and paraganglioma. An important gene associated with Ganglioneuroblastoma is MYCN (v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog), and among its related pathways is Neuroscience. The compounds vanillylmandelic acid and pentylenetetrazol have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, adrenal gland and bone, and related mouse phenotypes are behavior/neurological and normal.

Aliases & Classifications for Ganglioneuroblastoma

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 62UMLS, 34MeSH, 39NCIt, 57SNOMED-CT, 63UMLS via Orphanet
See all sources

Ganglioneuroblastoma, Aliases & Descriptions:

Name: Ganglioneuroblastoma 8 10 44 48 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
ganglioneuroblastoma:
Inheritance: Sporadic; Age of onset: Childhood


External Ids:

Disease Ontology8 DOID:4163
MeSH34 D018305
SNOMED-CT57 69515008
NCIt39 C3790
UMLS via Orphanet63 C0206718

Related Diseases for Ganglioneuroblastoma

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Diseases related to Ganglioneuroblastoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 98)
idRelated DiseaseScoreTop Affiliating Genes
1neuroblastoma30.9SYP, MYCN, VIP
2paraganglioma30.2SYP, S100B
3cushing's syndrome30.1SYP, NPY
4pheochromocytoma30.1VIP, MYCN, SYP, NPY
5ganglioglioma30.0S100B, SYP
6neurofibroma30.0S100B, SYP
7ganglioneuroma30.0VIP, MYCN, SYP, S100B, NPY
8adrenocortical carcinoma29.9SYP, VIP
9cerebral primitive neuroectodermal tumor10.5MYCN
10diarrhea10.4
11hirschsprung's disease10.4VIP
12papilloma10.4MYCN
13nodular ganglioneuroblastoma10.3
14hirschsprung disease ganglioneuroblastoma10.3
15peripheral nervous system ganglioneuroblastoma10.3
16mediastinum ganglioneuroblastoma10.3
17mediastinitis10.3
18ataxia10.3
19dysembryoplastic neuroepithelial tumor10.3SYP
20synovial sarcoma10.2S100B, MYCN
21neuronitis10.2
22cerebritis10.2
23neuroepithelioma10.2NPY, MYCN
24sex cord-gonadal stromal tumor10.2NPY, S100B
25peripheral primitive neuroectodermal tumor10.2S100B, MYCN
26adrenal gland ganglioneuroblastoma10.2
27cervicitis10.2
28paraneoplastic syndromes10.2
29rhinitis10.1NPY, VIP
30papillary ependymoma10.1S100B, SYP
31subependymal giant cell astrocytoma10.1SYP, S100B
32olfactory neuroblastoma10.1SYP, S100B
33choroid plexus papilloma10.1S100B, SYP
34rhabdomyosarcoma10.1S100B, MYCN
35pineocytoma10.1S100B, SYP
36granular cell tumor10.1SYP, S100B
37hypertension10.1
38wilms tumor10.1
39stroma-dominant and stroma-poor composite ganglioneuroblastoma10.1
40schwannian stroma-rich and stroma-poor composite ganglioneuroblastoma10.1
41gangliocytoma10.1
42intermixed schwannian stroma-rich ganglioneuroblastoma10.1
43hypokalemia10.1
44neurofibromatosis10.1
45phaeochromocytoma10.1
46osteomalacia10.1
47turner syndrome10.1
48myoclonus10.1
49hemangioblastoma10.1SYP, S100B
50pilocytic astrocytoma10.1SYP, S100B

Graphical network of the top 20 diseases related to Ganglioneuroblastoma:



Diseases related to ganglioneuroblastoma

Symptoms for Ganglioneuroblastoma

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Drugs & Therapeutics for Ganglioneuroblastoma

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Drug clinical trials:

Search ClinicalTrials for Ganglioneuroblastoma

Search NIH Clinical Center for Ganglioneuroblastoma

Genetic Tests for Ganglioneuroblastoma

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Anatomical Context for Ganglioneuroblastoma

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MalaCards organs/tissues related to Ganglioneuroblastoma:

32
Spinal cord, Adrenal gland, Bone, Brain, Bone marrow, Cerebellum, Kidney, Lung, Lymph node, Thymus, Colon, Myeloid, Pineal, Pituitary

Animal Models for Ganglioneuroblastoma or affiliated genes

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MGI Mouse Phenotypes related to Ganglioneuroblastoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.6NPY, S100B, MYCN, VIP
2MP:00028737.4NPY, S100B, SYP, MYCN, VIP

Publications for Ganglioneuroblastoma

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Articles related to Ganglioneuroblastoma:

(show top 50)    (show all 217)
idTitleAuthorsYear
1
Pediatric cerebral ganglioneuroblastoma. (25216629)
2014
2
Ventricular ganglioneuroblastoma in an adult and successful treatment with radiotherapy. (25207191)
2014
3
The neuroblastoma and ganglion components of nodular ganglioneuroblastoma are genetically similar: evidence against separate clonal origins. (25081755)
2014
4
Giant thoracoabdominal ganglioneuroblastoma in a 17-year-old patient. (24887835)
2013
5
Cerebral ganglioneuroblastoma of adult onset: two patients and a review of the literature. (22510501)
2012
6
Ganglioneuroblastoma: Case report and review of the literature. (23396255)
2011
7
Simultaneous tumors: acute myeloid leukemia infiltrating mediastinal ganglioneuroblastoma. (20973101)
2011
8
Ganglioneuroblastoma of the conus: a rare and aggressive tumor. (21150078)
2010
9
The low-affinity neurotrophin receptor, p75, is upregulated in ganglioneuroblastoma/ganglioneuroma and reduces tumorigenicity of neuroblastoma cells in vivo. (19142969)
2009
10
Nodular ganglioneuroblastoma in adults. (19680497)
2009
11
Genome analysis and gene expression profiling of neuroblastoma and ganglioneuroblastoma reveal differences between neuroblastic and Schwannian stromal cells. (16178058)
2005
12
Canine ganglioneuroblastoma in the oral mucosa. (15003480)
2004
13
Adult-type ganglioneuroblastoma in the adrenal gland treated by a laparoscopic resection: report of a case. (14513331)
2003
14
Shoulder pain in a child: a case presentation of ganglioneuroblastoma. (10754787)
2000
15
Primary pulmonary ganglioneuroblastoma: a clinicopathologic and immunohistochemical study of two cases. (9845734)
1998
16
Simultaneous adrenocortical carcinoma and ganglioneuroblastoma in a child with Turner syndrome and germline p53 mutation. (9598730)
1998
17
Ganglioneuroblastoma and ganglioneuroma in association with neurofibromatosis type I: report of three cases. (9701489)
1998
18
Adult ganglioneuroblastoma of the anterior mediastinum. (9505266)
1997
19
Cerebellin and cerebellin mRNA in the human brain, adrenal glands and the tumour tissues of adrenal tumour, ganglioneuroblastoma and neuroblastoma. (9246935)
1997
20
Central hypoventilation syndrome associated with ganglioneuroblastoma. (8555134)
1995
21
An immunohistochemical study of peripheral neuroblastoma, ganglioneuroblastoma, anaplastic ganglioglioma, schwannoma and neurofibroma in cattle. (7962722)
1994
22
Pathologic quiz case 1. Cervical ganglioneuroblastoma. (8318213)
1993
23
N-myc gene amplification/expression in localized stroma-rich neuroblastoma (ganglioneuroblastoma). (8454274)
1993
24
Isolation of chromosome-specific DNA sequences from an Alu polymerase chain reaction library to define the breakpoint in a patient with a constitutional translocation t(1;13) (q22;q12) and ganglioneuroblastoma. (1630820)
1992
25
An adrenaline-secreting ganglioneuroblastoma with elevated urinary HMMA but normal metanephrine excretion. (1489167)
1992
26
Neuropeptide Y as a plasma marker for phaeochromocytoma, ganglioneuroblastoma and neuroblastoma. (1327637)
1992
27
Intestinal ganglioneuroblastoma in a 22-week fetus. (1409156)
1992
28
Ganglioneuroblastoma and urticaria by physical agents. (2368174)
1990
29
Identification of 5-HT1A recognition sites in human ganglioneuroblastoma. (2575526)
1989
30
Bilateral adrenal ganglioneuroblastoma with neuromelanin. Clinical and pathologic observations. (3277701)
1988
31
False positive bone scan secondary to sympathectomy following resection of a ganglioneuroblastoma or affect of unilateral sympathectomy of bone scan in the pediatric patient. (3352830)
1988
32
Primary small bowel ganglioneuroblastoma and Friedreich's ataxia. (3585899)
1987
33
Cervical ganglioneuroblastoma. (3572236)
1987
34
Malignant pheochromocytoma with ganglioneuroblastoma elements in a patient with von Recklinghausen's disease. (3922614)
1985
35
The isolation and sequence analysis of vasoactive intestinal peptide from a ganglioneuroblastoma. (6092409)
1984
36
The role of surgery, radio- and chemotherapy in the treatment of neuroblastoma and ganglioneuroblastoma. (6878720)
1983
37
Extraosseous localization of 99mTc-MDP in ganglioneuroblastoma. (6214400)
1982
38
Primary pulmonary ganglioneuroblastoma in an adult: maturation, involution and the immune response. (7275023)
1981
39
Intrathoracic ganglioneuroblastoma. (7421294)
1980
40
Case report. Computer assisted tomographic evaluation of a ganglioneuroblastoma in an adult. (422782)
1979
41
Histopathological study of an imperfect type ganglioneuroblastoma. (462578)
1979
42
Intractable diarrhea in a boy with vasoactive intestinal peptide-producing ganglioneuroblastoma. (854377)
1977
43
Pigmented ganglioneuroblastoma: relation of melanin and lipofuscin to schwannomas and other tumors of neural crest origin. (180265)
1976
44
Bilateral adrenal ganglioneuroblastoma in a premature calf. (962741)
1976
45
Retroperitoneal ganglioneuroblastoma: a kaleidoscope of neuronal degeneration. A light and electron microscopic study. (173810)
1976
46
Ganglioneuroblastoma associated with malignant mesenchymoma. (1182658)
1975
47
Metastatic ganglioneuroblastoma: report of case and review of the literature. (4600171)
1974
48
Metastatic ganglioneuroblastoma. Ultrastructural, histochemical, and virological studies in a case. (5343392)
1969
49
Ganglioneuroblastoma: angiographic-histologic correlation. (5769305)
1969
50
Multiple tumors of the sympathetic nervous system: Report of a case showing a distinct ganglioneuroma, a neuroblastoma and a cystic calcifying ganglioneuroblastoma. (19970419)
1938

Variations for Ganglioneuroblastoma

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Expression for genes affiliated with Ganglioneuroblastoma

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Expression patterns in normal tissues for genes affiliated with Ganglioneuroblastoma

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Pathways for genes affiliated with Ganglioneuroblastoma

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Pathways related to Ganglioneuroblastoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
18.3NPY, S100B, SYP, MYCN

Compounds for genes affiliated with Ganglioneuroblastoma

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Compounds related to Ganglioneuroblastoma according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1vanillylmandelic acid44 2410.9MYCN, VIP
2pentylenetetrazol449.9NPY, S100B
3arginine vasotocin449.8VIP, NPY
4secretoneurin449.8VIP, NPY
5helospectin449.8VIP, NPY
6methoxamine44 28 1111.8NPY, VIP
7pacap 38449.8NPY, VIP
8guanethidine44 1110.8VIP, NPY
9alpha msh449.8NPY, VIP
10phentolamine44 28 1111.7VIP, NPY
11oxyntomodulin44 6110.7VIP, NPY
12trifluoroethanol44 1110.7NPY, VIP
13phosphoramidon44 1110.6VIP, NPY
14s 100449.6S100B, SYP
15reticulin449.5SYP, S100B
16mucicarmine449.5S100B, SYP
17pertussis449.4VIP, NPY
18l-amino acid449.4S100B, SYP
19sodium nitroprusside449.4VIP, S100B, NPY
20b 723449.4SYP, S100B
216-hydroxydopamine449.1NPY, VIP
22etoposide44 50 61 1112.1S100B, SYP, MYCN
23formaldehyde44 2410.0NPY, S100B, SYP
24streptozotocin449.0NPY, SYP
25haloperidol44 50 28 2 1113.0VIP, SYP, NPY
265-hydroxytryptamine449.0VIP, SYP, NPY
27lactate449.0NPY, S100B, MYCN, VIP
28histamine44 28 2410.8VIP, SYP, NPY
29potassium44 24 1110.8S100B, SYP, VIP
30gtp44 289.7S100B, SYP, VIP
31dbc-amp448.7VIP, MYCN, SYP, S100B
32paraffin448.7NPY, S100B, SYP, MYCN
33creatinine448.7NPY, S100B, SYP
34vegf448.6VIP, MYCN, SYP, S100B
35choline44 24 1110.6NPY, S100B, SYP, VIP
36acth448.6VIP, SYP, S100B, NPY
37gaba448.6NPY, S100B, SYP, VIP
38norepinephrine44 24 1110.6NPY, S100B, SYP, VIP
39acetylcholine44 50 28 24 1112.6VIP, SYP, S100B, NPY
40forskolin44 50 1110.6VIP, SYP, S100B, NPY
41glutamine448.6VIP, SYP, S100B, NPY
42cyclic amp44 249.6NPY, S100B, SYP, VIP
43retinoic acid44 249.5MYCN, SYP, S100B, NPY
44testosterone44 61 24 1111.5VIP, SYP, S100B, NPY
45glutamate448.5VIP, SYP, S100B, NPY
46estrogen448.4VIP, SYP, S100B, NPY
47catecholamine448.2NPY, S100B, SYP, MYCN, VIP
48dopamine44 28 24 1111.2VIP, MYCN, SYP, S100B, NPY
49nitric oxide44 24 1110.2VIP, MYCN, SYP, S100B, NPY
50tyrosine448.1VIP, MYCN, SYP, S100B, NPY

GO Terms for genes affiliated with Ganglioneuroblastoma

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Biological processes related to Ganglioneuroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of cell shapeGO:0083609.4S100B, WASF3
2learning or memoryGO:0076119.2S100B, VIP
3regulation of neuronal synaptic plasticityGO:0481689.1S100B, SYP

Molecular functions related to Ganglioneuroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.4NPY, VIP

Products for genes affiliated with Ganglioneuroblastoma

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  • Antibodies
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Sources for Ganglioneuroblastoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet