MCID: GNG008
MIFTS: 46

Ganglioneuroblastoma malady

Neuronal diseases, Cancer diseases, Rare diseases categories

Summaries for Ganglioneuroblastoma

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Wikipedia:65 Ganglioneuroblastoma is a variant of neuroblastoma that is surrounded by ganglion cells. more...

MalaCards based summary: Ganglioneuroblastoma is related to neuroblastoma and ganglioneuroma. An important gene associated with Ganglioneuroblastoma is MYCN (v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog), and among its related pathways is Neuroscience. The compounds vanillylmandelic acid and pentylenetetrazol have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone and brain, and related mouse phenotypes are behavior/neurological and normal.

Aliases & Classifications for Ganglioneuroblastoma

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Sources:
10Disease Ontology, 12DISEASES, 45Novoseek, 49Orphanet, 62UMLS, 40NCIt, 35MeSH, 57SNOMED-CT, 63UMLS via Orphanet
See all sources

Ganglioneuroblastoma, Aliases & Descriptions:

Name: Ganglioneuroblastoma 10 12 45 49 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

49
ganglioneuroblastoma:
Inheritance: Not applicable; Age of onset: Childhood,Infancy


External Ids:

Disease Ontology10 DOID:4163
NCIt40 C3790
MeSH35 D018305
SNOMED-CT57 69515008
Orphanet49 251877
UMLS via Orphanet63 C0206718

Related Diseases for Ganglioneuroblastoma

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Diseases related to Ganglioneuroblastoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 97)
idRelated DiseaseScoreTop Affiliating Genes
1neuroblastoma31.0MYCN, VIP, SYP
2ganglioneuroma30.6VIP, MYCN, SYP, S100B, NPY
3pheochromocytoma30.5VIP, MYCN, SYP, NPY
4paraganglioma30.1S100B, SYP
5cushing's syndrome30.1NPY, SYP
6ganglioglioma29.9S100B, SYP
7neurofibroma29.9SYP, S100B
8adrenocortical carcinoma29.9SYP, VIP
9diarrhea10.4
10nodular ganglioneuroblastoma10.4
11hirschsprung disease ganglioneuroblastoma10.3
12peripheral nervous system ganglioneuroblastoma10.3
13mediastinum ganglioneuroblastoma10.3
14mediastinitis10.3
15ataxia10.3
16neuronitis10.2
17cerebritis10.2
18adrenal gland ganglioneuroblastoma10.2
19cervicitis10.2
20paraneoplastic syndromes10.2
21wilms tumor10.1
22intermixed schwannian stroma-rich ganglioneuroblastoma10.1
23stroma-dominant and stroma-poor composite ganglioneuroblastoma10.1
24schwannian stroma-rich and stroma-poor composite ganglioneuroblastoma10.1
25neurofibromatosis10.1
26gangliocytoma10.1
27osteomalacia10.1
28hypokalemia10.1
29phaeochromocytoma10.1
30turner syndrome10.1
31myoclonus10.1
32cerebral primitive neuroectodermal tumor10.1MYCN
33papilloma10.0MYCN
34hirschsprung disease 110.0VIP
35dysembryoplastic neuroepithelial tumor10.0SYP
36glomus tumor10.0SYP
37sarcoma, synovial10.0S100B, MYCN
38ewing sarcoma10.0NPY, MYCN
39sex cord-gonadal stromal tumor10.0S100B, NPY
40peripheral primitive neuroectodermal tumor10.0S100B, MYCN
41rhinitis10.0NPY, VIP
42papillary ependymoma10.0SYP, S100B
43olfactory neuroblastoma10.0SYP, S100B
44subependymal giant cell astrocytoma10.0S100B, SYP
45choroid plexus papilloma10.0S100B, SYP
46rhabdomyosarcoma10.0S100B, MYCN
47pineocytoma10.0S100B, SYP
48granular cell tumor10.0S100B, SYP
49hemangioblastoma10.0SYP, S100B
50pilocytic astrocytoma10.0S100B, SYP

Graphical network of the top 20 diseases related to Ganglioneuroblastoma:



Diseases related to ganglioneuroblastoma

Symptoms for Ganglioneuroblastoma

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Drugs & Therapeutics for Ganglioneuroblastoma

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Drug clinical trials:

Search ClinicalTrials for Ganglioneuroblastoma

Search NIH Clinical Center for Ganglioneuroblastoma

Genetic Tests for Ganglioneuroblastoma

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Anatomical Context for Ganglioneuroblastoma

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MalaCards organs/tissues related to Ganglioneuroblastoma:

33
Spinal cord, Bone, Brain, Adrenal gland, Bone marrow, Cerebellum, Kidney, Lung, Lymph node, Thymus, Colon, Myeloid, Pineal, Pituitary

Animal Models for Ganglioneuroblastoma or affiliated genes

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MGI Mouse Phenotypes related to Ganglioneuroblastoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.6NPY, S100B, MYCN, VIP
2MP:00028737.4NPY, S100B, SYP, MYCN, VIP

Publications for Ganglioneuroblastoma

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Articles related to Ganglioneuroblastoma:

(show top 50)    (show all 213)
idTitleAuthorsYear
1
Adult adrenal ganglioneuroblastoma: A rare case report. (25737766)
2015
2
Pediatric cerebral ganglioneuroblastoma. (25216629)
2014
3
Ventricular ganglioneuroblastoma in an adult and successful treatment with radiotherapy. (25207191)
2014
4
The neuroblastoma and ganglion components of nodular ganglioneuroblastoma are genetically similar: evidence against separate clonal origins. (25081755)
2014
5
Giant thoracoabdominal ganglioneuroblastoma in a 17-year-old patient. (24887835)
2013
6
Cerebral ganglioneuroblastoma of adult onset: two patients and a review of the literature. (22510501)
2012
7
Ganglioneuroblastoma: Case report and review of the literature. (23396255)
2011
8
Simultaneous tumors: acute myeloid leukemia infiltrating mediastinal ganglioneuroblastoma. (20973101)
2011
9
Ganglioneuroblastoma of the conus: a rare and aggressive tumor. (21150078)
2010
10
The low-affinity neurotrophin receptor, p75, is upregulated in ganglioneuroblastoma/ganglioneuroma and reduces tumorigenicity of neuroblastoma cells in vivo. (19142969)
2009
11
Nodular ganglioneuroblastoma in adults. (19680497)
2009
12
Genome analysis and gene expression profiling of neuroblastoma and ganglioneuroblastoma reveal differences between neuroblastic and Schwannian stromal cells. (16178058)
2005
13
Canine ganglioneuroblastoma in the oral mucosa. (15003480)
2004
14
Adult-type ganglioneuroblastoma in the adrenal gland treated by a laparoscopic resection: report of a case. (14513331)
2003
15
Shoulder pain in a child: a case presentation of ganglioneuroblastoma. (10754787)
2000
16
Primary pulmonary ganglioneuroblastoma: a clinicopathologic and immunohistochemical study of two cases. (9845734)
1998
17
Simultaneous adrenocortical carcinoma and ganglioneuroblastoma in a child with Turner syndrome and germline p53 mutation. (9598730)
1998
18
Ganglioneuroblastoma and ganglioneuroma in association with neurofibromatosis type I: report of three cases. (9701489)
1998
19
Adult ganglioneuroblastoma of the anterior mediastinum. (9505266)
1997
20
Cerebellin and cerebellin mRNA in the human brain, adrenal glands and the tumour tissues of adrenal tumour, ganglioneuroblastoma and neuroblastoma. (9246935)
1997
21
Central hypoventilation syndrome associated with ganglioneuroblastoma. (8555134)
1995
22
An immunohistochemical study of peripheral neuroblastoma, ganglioneuroblastoma, anaplastic ganglioglioma, schwannoma and neurofibroma in cattle. (7962722)
1994
23
Pathologic quiz case 1. Cervical ganglioneuroblastoma. (8318213)
1993
24
N-myc gene amplification/expression in localized stroma-rich neuroblastoma (ganglioneuroblastoma). (8454274)
1993
25
Isolation of chromosome-specific DNA sequences from an Alu polymerase chain reaction library to define the breakpoint in a patient with a constitutional translocation t(1;13) (q22;q12) and ganglioneuroblastoma. (1630820)
1992
26
An adrenaline-secreting ganglioneuroblastoma with elevated urinary HMMA but normal metanephrine excretion. (1489167)
1992
27
Neuropeptide Y as a plasma marker for phaeochromocytoma, ganglioneuroblastoma and neuroblastoma. (1327637)
1992
28
Intestinal ganglioneuroblastoma in a 22-week fetus. (1409156)
1992
29
Ganglioneuroblastoma and urticaria by physical agents. (2368174)
1990
30
Identification of 5-HT1A recognition sites in human ganglioneuroblastoma. (2575526)
1989
31
Bilateral adrenal ganglioneuroblastoma with neuromelanin. Clinical and pathologic observations. (3277701)
1988
32
False positive bone scan secondary to sympathectomy following resection of a ganglioneuroblastoma or affect of unilateral sympathectomy of bone scan in the pediatric patient. (3352830)
1988
33
Primary small bowel ganglioneuroblastoma and Friedreich's ataxia. (3585899)
1987
34
Cervical ganglioneuroblastoma. (3572236)
1987
35
Malignant pheochromocytoma with ganglioneuroblastoma elements in a patient with von Recklinghausen's disease. (3922614)
1985
36
The isolation and sequence analysis of vasoactive intestinal peptide from a ganglioneuroblastoma. (6092409)
1984
37
The role of surgery, radio- and chemotherapy in the treatment of neuroblastoma and ganglioneuroblastoma. (6878720)
1983
38
Extraosseous localization of 99mTc-MDP in ganglioneuroblastoma. (6214400)
1982
39
Primary pulmonary ganglioneuroblastoma in an adult: maturation, involution and the immune response. (7275023)
1981
40
Case report. Computer assisted tomographic evaluation of a ganglioneuroblastoma in an adult. (422782)
1979
41
Histopathological study of an imperfect type ganglioneuroblastoma. (462578)
1979
42
Intractable diarrhea in a boy with vasoactive intestinal peptide-producing ganglioneuroblastoma. (854377)
1977
43
Pigmented ganglioneuroblastoma: relation of melanin and lipofuscin to schwannomas and other tumors of neural crest origin. (180265)
1976
44
Bilateral adrenal ganglioneuroblastoma in a premature calf. (962741)
1976
45
Retroperitoneal ganglioneuroblastoma: a kaleidoscope of neuronal degeneration. A light and electron microscopic study. (173810)
1976
46
Ganglioneuroblastoma associated with malignant mesenchymoma. (1182658)
1975
47
Metastatic ganglioneuroblastoma: report of case and review of the literature. (4600171)
1974
48
Metastatic ganglioneuroblastoma. Ultrastructural, histochemical, and virological studies in a case. (5343392)
1969
49
Ganglioneuroblastoma: angiographic-histologic correlation. (5769305)
1969
50
Multiple tumors of the sympathetic nervous system: Report of a case showing a distinct ganglioneuroma, a neuroblastoma and a cystic calcifying ganglioneuroblastoma. (19970419)
1938

Variations for Ganglioneuroblastoma

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Expression for genes affiliated with Ganglioneuroblastoma

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Search GEO for disease gene expression data for Ganglioneuroblastoma.

Pathways for genes affiliated with Ganglioneuroblastoma

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Pathways related to Ganglioneuroblastoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
18.3NPY, S100B, SYP, MYCN

Compounds for genes affiliated with Ganglioneuroblastoma

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Compounds related to Ganglioneuroblastoma according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1vanillylmandelic acid45 2610.9MYCN, VIP
2pentylenetetrazol459.9NPY, S100B
3arginine vasotocin459.8VIP, NPY
4secretoneurin459.8VIP, NPY
5helospectin459.8VIP, NPY
6methoxamine45 30 1311.8NPY, VIP
7pacap 38459.8NPY, VIP
8guanethidine45 1310.8VIP, NPY
9alpha msh459.8NPY, VIP
10phentolamine45 30 1311.7VIP, NPY
11oxyntomodulin45 6110.7VIP, NPY
12trifluoroethanol45 1310.7NPY, VIP
13phosphoramidon45 1310.6VIP, NPY
14s 100459.6S100B, SYP
15reticulin459.5SYP, S100B
16mucicarmine459.5S100B, SYP
17pertussis459.4VIP, NPY
18l-amino acid459.4S100B, SYP
19sodium nitroprusside459.4VIP, S100B, NPY
20b 723459.4SYP, S100B
216-hydroxydopamine459.1NPY, VIP
22etoposide45 51 61 1312.1S100B, SYP, MYCN
23formaldehyde45 2610.0NPY, S100B, SYP
24streptozotocin459.0NPY, SYP
25haloperidol45 51 30 3 1313.0VIP, SYP, NPY
265-hydroxytryptamine459.0VIP, SYP, NPY
27lactate459.0NPY, S100B, MYCN, VIP
28histamine45 30 2610.8VIP, SYP, NPY
29potassium45 26 1310.8S100B, SYP, VIP
30gtp45 309.7S100B, SYP, VIP
31dbc-amp458.7VIP, MYCN, SYP, S100B
32paraffin458.7NPY, S100B, SYP, MYCN
33creatinine458.7NPY, S100B, SYP
34vegf458.6VIP, MYCN, SYP, S100B
35choline45 26 1310.6NPY, S100B, SYP, VIP
36acth458.6VIP, SYP, S100B, NPY
37gaba458.6NPY, S100B, SYP, VIP
38norepinephrine45 26 1310.6NPY, S100B, SYP, VIP
39acetylcholine45 51 30 26 1312.6VIP, SYP, S100B, NPY
40forskolin45 51 1310.6VIP, SYP, S100B, NPY
41glutamine458.6VIP, SYP, S100B, NPY
42cyclic amp45 269.6NPY, S100B, SYP, VIP
43retinoic acid45 269.5MYCN, SYP, S100B, NPY
44testosterone45 61 26 1311.5VIP, SYP, S100B, NPY
45glutamate458.5VIP, SYP, S100B, NPY
46estrogen458.4VIP, SYP, S100B, NPY
47catecholamine458.2NPY, S100B, SYP, MYCN, VIP
48dopamine45 30 26 1311.2VIP, MYCN, SYP, S100B, NPY
49nitric oxide45 26 1310.2VIP, MYCN, SYP, S100B, NPY
50tyrosine458.1VIP, MYCN, SYP, S100B, NPY

GO Terms for genes affiliated with Ganglioneuroblastoma

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Biological processes related to Ganglioneuroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of cell shapeGO:00083609.4S100B, WASF3
2learning or memoryGO:00076119.2S100B, VIP
3regulation of neuronal synaptic plasticityGO:00481689.1S100B, SYP

Molecular functions related to Ganglioneuroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:00051849.4NPY, VIP

Products for genes affiliated with Ganglioneuroblastoma

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Sources for Ganglioneuroblastoma

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet