MCID: GNG008
MIFTS: 53

Ganglioneuroblastoma malady

Neuronal diseases, Cancer diseases categories

Summaries for Ganglioneuroblastoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Ganglioneuroblastoma is a variant of neuroblastoma that is surrounded by ganglion cells. more...

MalaCards: Ganglioneuroblastoma is related to neuroblastoma and ganglioneuroma. An important gene associated with Ganglioneuroblastoma is MYCN (v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog), and among its related pathways are Neuroscience and Signaling by GPCR. The compounds glutamate and creatinine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, adrenal gland and bone, and related mouse phenotypes are respiratory system and muscle.

Aliases & Classifications for Ganglioneuroblastoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
ganglioneuroblastoma:
Inheritance: Sporadic; Age of onset: Childhood


Aliases & Descriptions:

ganglioneuroblastoma 8 10 44 48 60


External Ids:

Disease Ontology8 DOID:4163
NCIt39 C3790
SNOMED-CT56 69515008
MeSH34 D018305
SNOMED-CT via Orphanet57 69515008

Related Diseases for Ganglioneuroblastoma

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17GeneCards, 18GeneDecks
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Diseases related to Ganglioneuroblastoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 185)
idRelated DiseaseScoreTop Affiliating Genes
1neuroblastoma30.9VIP, SYP, NTRK1, MYCN, TH, ENO2
2ganglioneuroma30.6MYCN, NTRK1, CHGA, SYP, CD44, NPY
3diarrhea30.5TOP1, CHGA, VIP
4pheochromocytoma30.4NPY, VIP, ADM, ENO2, TH, HCRT
5hypokalemia30.0VIP
6adrenal neuroblastoma30.0MYCN
7hypertension30.0NPY, TH, ADM
8phaeochromocytoma30.0NPY, CHGA, ADM
9cushing's syndrome30.0NPY, SYP, CHGA
10paraganglioma30.0ENO2, SYP, S100B, TH, CHGA
11hepatitis29.8MYCN
12constipation29.8VIP
13gangliocytoma29.8SYP
14neurofibroma29.8S100B, SYP
15adrenocortical carcinoma29.8CHGA, VIP, SYP, ADM
16vipoma29.8VIP, CHGA
17adenoma29.8ENO2, SYP, CHGA, NTRK1, CD44
18ganglioglioma29.8NTRK1, TH, CHGA, SYP, S100B, ENO2
19leukemia29.8NTRK1, CD44, ABCB1, MYCN, DLL1, TOP1
20nodular ganglioneuroblastoma10.3
21mediastinum ganglioneuroblastoma10.3
22adrenal gland ganglioneuroblastoma10.3
23hirschsprung disease ganglioneuroblastoma10.3
24peripheral nervous system ganglioneuroblastoma10.2
25mediastinitis10.2
26syndromic diarrhea10.2
27neuronitis10.2
28cerebritis10.1
29differentiating neuroblastoma10.1
30cervicitis10.1
31neurofibromatosis10.0
32intermixed schwannian stroma-rich ganglioneuroblastoma10.0
33functional diarrhea10.0
34osteomalacia10.0
35stroma-dominant and stroma-poor composite ganglioneuroblastoma10.0
36schwannian stroma-rich and stroma-poor composite ganglioneuroblastoma10.0
37turner syndrome10.0
38rhabdoid tumor10.0SYP
39von hippel-lindau disease10.0NPY
40dysembryoplastic neuroepithelial tumor10.0SYP
41thymoma10.0NTRK1
42alcohol dependence10.0NPY
43primary hyperoxaluria10.0CD44
44oligodendroglioma10.0SYP
45cerebral primitive neuroectodermal tumor10.0MYCN
46papilloma10.0MYCN
47epulis10.0ENO2
48tuberous sclerosis10.0S100B, SYP
49leishmaniasis10.0TOP1
50leiomyosarcoma10.0ENO2, S100B

Graphical network of the top 20 diseases related to Ganglioneuroblastoma:



Diseases related to ganglioneuroblastoma

Clinical Features for Ganglioneuroblastoma

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Drugs & Therapeutics for Ganglioneuroblastoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Ganglioneuroblastoma

Drug clinical trials:

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Search NIH Clinical Center for Ganglioneuroblastoma

Search CenterWatch for Ganglioneuroblastoma

Genetic Tests for Ganglioneuroblastoma

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Anatomical Context for Ganglioneuroblastoma

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32MalaCards
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MalaCards organs/tissues related to Ganglioneuroblastoma:

32
Spinal cord, Adrenal gland, Bone, Brain, Kidney, Bone marrow, Cerebellum, Colon, Pituitary, Myeloid, Thymus, Lung, Lymph node, Pineal

Animal Models for Ganglioneuroblastoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Ganglioneuroblastoma:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053889.3VIP, MYCN, HCRT, CD44, TH, ENO2
2MP:00053699.2NTRK1, MYCN, HCRT, DLL1, DLK1
3MP:00053679.2CHGA, MYCN, CD44, DLL1, ADM, NPY
4MP:00053709.0NPY, MYCN, CD44, DLK1, ABCB1, TH
5MP:00028738.7SYP, NPY, S100B, VIP, NTRK1, CBLN3
6MP:00053768.5GALP, NPY, HTR1A, VIP, MYCN, HCRT
7MP:00053858.2VIP, HTR1A, CHGA, MYCN, HCRT, CD44
8MP:00036318.0CBLN3, NTRK1, SYP, NPY, HTR1A, MYCN
9MP:00053788.0NPY, GALP, CHGA, NTRK1, MYCN, HCRT
10MP:00107687.9NTRK1, CHGA, TOP1, HTR1A, VIP, MYCN
11MP:00053867.5ADM, VIP, S100B, HTR1A, NPY, GALP

Publications for Ganglioneuroblastoma

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50PubMed
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Articles related to Ganglioneuroblastoma:

(show top 50)    (show all 207)
idTitleAuthorsYear
1
Recurrent multiple spinal paragangliomas as a manifestation of a metastatic composite paraganglioma-ganglioneuroblastoma. (23532344)
2013
2
Ganglioneuroblastoma masquerading as a traumatic lumbar artery injury and hematoma. (22273290)
2012
3
High anaplastic lymphoma kinase immunohistochemical staining in neuroblastoma and ganglioneuroblastoma is an independent predictor of poor outcome. (22203052)
2012
4
Ganglioneuroblastoma, intermixed with opsoclonus-myoclonus syndrome. (22631586)
2012
5
Primary intraspinal ganglioneuroblastoma of the thoracic spine: a rare case report. (23455798)
2012
6
Ganglioneuroblastoma: Case report and review of the literature. (23396255)
2011
7
Ganglioneuroblastoma of the posterior mediastinum: a case report. (21781292)
2011
8
The low-affinity neurotrophin receptor, p75, is upregulated in ganglioneuroblastoma/ganglioneuroma and reduces tumorigenicity of neuroblastoma cells in vivo. (19142969)
2009
9
Ganglioneuroblastoma-associated vitamin D deficiency rickets. (19564745)
2009
10
Parapharyngeal malignant peripheral nerve sheath tumour in conjunction with ganglioneuroblastoma involving the mandible. (19566891)
2009
11
Expression of brain-derived neurotrophic factor and tropomyosin-related kinase-B in a bovine jejunal nodular ganglioneuroblastoma. (18487493)
2008
12
Ganglioneuroblastoma in a cat: a rare neoplasm treated with electrochemotherapy. (17910926)
2008
13
Growth hormone deficiency after localized ganglioneuroblastoma: A case report. (17006271)
2006
14
Extradural spinal cord and intraabdominal ganglioneuroblastoma. (16515125)
2005
15
Canine ganglioneuroblastoma in the oral mucosa. (15003480)
2004
16
Ondine's curse associated with Hirschsprung disease and ganglioneuroblastoma. (11753172)
2002
17
Intestinal pseudoobstruction as a paraneoplastic syndrome in ganglioneuroblastoma. (12548500)
2002
18
Simultaneous adrenocortical carcinoma and ganglioneuroblastoma in a child with Turner syndrome and germline p53 mutation. (9598730)
1998
19
Ganglioneuroblastoma and ganglioneuroma in association with neurofibromatosis type I: report of three cases. (9701489)
1998
20
Adult ganglioneuroblastoma of the anterior mediastinum. (9505266)
1997
21
Cerebellin and cerebellin mRNA in the human brain, adrenal glands and the tumour tissues of adrenal tumour, ganglioneuroblastoma and neuroblastoma. (9246935)
1997
22
Conventional versus modified morphologic criteria for ganglioneuroblastoma. A review of cases from the Pediatric Oncology Group. (9140292)
1996
23
Ganglioneuroblastoma masquerading as chronic vomiting. (7729106)
1995
24
Cytopathology of neuroblastoma, ganglioneuroblastoma and ganglioneuroma. (8648154)
1995
25
Magnetic resonance imaging of neuroblastoma, ganglioneuroblastoma, and ganglioneuroma. (8592928)
1995
26
Neurocristopathy in mother (ganglioneuroblastoma) and daughter (aganglionosis): incidental or causal? (7811432)
1994
27
Association of ganglioneuroblastoma with horse-shoe kidney. (7808041)
1994
28
Constructing a physical map around a constitutional t(1;13)(q22;q12) breakpoint in a patient with a ganglioneuroblastoma. (7972239)
1994
29
Spinal ganglioneuroblastoma--complete response to chemotherapy alone. (8255850)
1993
30
Pituitary adenylate cyclase activating polypeptide (PACAP)-like immunoreactivity in ganglioneuroblastoma and neuroblastoma. (8278630)
1993
31
Intestinal ganglioneuroblastoma in a 22-week fetus. (1409156)
1992
32
Scoliosis associated with ganglioneuroblastoma: a case report with 17-year follow-up. (1571610)
1992
33
Ganglioneuroblastoma with disseminated bone marrow infiltration in an adult. (1295633)
1992
34
A case of cerebral composite ganglioneuroblastoma: an immunohistochemical and ultrastructural study. (2360422)
1990
35
Association of ganglioneuroblastoma with syringomyelia. Case report. (2543525)
1989
36
False positive bone scan secondary to sympathectomy following resection of a ganglioneuroblastoma or affect of unilateral sympathectomy of bone scan in the pediatric patient. (3352830)
1988
37
Cervical ganglioneuroblastoma. (3572236)
1987
38
Histopathologic prognostic factors in neuroblastic tumors: definition of subtypes of ganglioneuroblastoma and an age-linked classification of neuroblastomas. (6589432)
1984
39
Primary ganglioneuroblastoma of the anterior mediastinum in a 61-year-old woman. (6662513)
1983
40
Ganglioneuroblastoma containing several kinds of neuronal peptides with watery diarrhea syndrome. (6291317)
1982
41
A subdural metastasis of an adrenal ganglioneuroblastoma. Presenting clinically as an intracranial lesion in an 11-year-old boy. (639422)
1978
42
Maturation and anaplasia in neuronal tumors of the peripheral nervous system; with observations on the glial-like tissues in the ganglioneuroblastoma. (69684)
1977
43
Ganglioneuroblastoma in an adult human albino. (5124989)
1971
44
Chronic diarrhea with ganglioneuroblastoma. (5564986)
1971
45
Metastatic ganglioneuroblastoma. Ultrastructural, histochemical, and virological studies in a case. (5343392)
1969
46
Ganglioneuroblastoma: angiographic-histologic correlation. (5769305)
1969
47
Chronic diarrhea in an adult with hypokalemic nephropathy and osteomalacia due to functioning ganglioneuroblastoma. (6021377)
1967
48
GANGLIONEUROBLASTOMA. STUDIES OF PATHOLOGIC CHANGES AND CONTENT OF CATECHOLAMINE. (14202147)
1964
49
Ganglioneuroblastoma. A case involving the superior cervical ganglion. (13738460)
1961
50
Ganglioneuroblastoma associated with chronic diarrhea and increased excretion of catecholamines: preliminary report. (13834658)
1959

Genetic Variations for Ganglioneuroblastoma

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Expression for genes affiliated with Ganglioneuroblastoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ganglioneuroblastoma

Search GEO for disease gene expression data for Ganglioneuroblastoma.

Pathways for genes affiliated with Ganglioneuroblastoma

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4Cell Signaling Technology, 53Reactome
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Pathways related to Ganglioneuroblastoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
18.9ENO2, S100B, HTR1A, NPY, SYP, NTRK1
2
Hide members
8.5S100B, HTR1A, NPY, NTRK1, HCRT, DLL1

Compounds for genes affiliated with Ganglioneuroblastoma

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44Novoseek, 59Tocris Bioscience, 24HMDB, 49PharmGKB, 11DrugBank, 28IUPHAR, 2BitterDB
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Compounds related to Ganglioneuroblastoma according to GeneCards/GeneDecks:

(show top 50)    (show all 152)
idCompoundScoreTop Affiliating Genes
1glutamate4410.2NPY, HCRT, NTRK1
2creatinine4410.0SYP, NPY, NTRK1, CHGA
3s 100449.9S100B, CHGA, SYP, ENO2
4oxyntomodulin44 5910.9HCRT, CHGA, NPY, VIP
5galp449.9NPY, HCRT, GALP
6homovanillic acid44 2410.8CHGA, MYCN, ENO2, TH
7vanillylmandelic acid44 2410.8CHGA, MYCN, VIP, TH, ENO2
8smcc449.8ENO2, CHGA, SYP
9forskolin44 49 1111.8NPY, ADM, ENO2, TH, GALP
10l-amino acid449.8S100B, TH, CHGA, ENO2, SYP
11tetrodotoxin44 59 2811.7TH, ENO2, HCRT, NPY, VIP
12mibg449.7ENO2, ADM, VIP, TH, CHGA
13etoposide44 49 59 1112.7TOP1, CHGA, CD44, ABCB1, MYCN, S100B
14dbc-amp449.7ADM, VIP, SYP, ENO2, MYCN, S100B
15dexamethasone44 49 28 1112.7ENO2, TH, ABCB1, S100B, VIP, HCRT
16sodium nitroprusside449.6ADM, VIP, S100B, NPY, TH
17propranolol44 28 49 11 2413.6VIP, HTR1A, CHGA, ABCB1, ADM
18carbachol44 28 1111.5VIP, TH, NPY, CHGA, HCRT, ADM
19choline44 11 2411.5NPY, S100B, VIP, SYP, NTRK1, TH
20carboplatin44 49 1111.5TOP1, ENO2, ABCB1, CHGA, CD44
21gnrh449.4GALP, CHGA, VIP, TH, CD44, NTRK1
22histamine44 28 2411.3HCRT, VIP, NPY, SYP, TH, ADM
23p003449.3CHGA, CD44, ADM, NTRK1, S100B
24glutamine449.3VIP, S100B, NPY, TOP1, TH, ENO2
25corticosterone44 59 2411.3NPY, VIP, CBLN3, HCRT, HTR1A, TH
26guanine44 11 2411.3VIP, HTR1A, CHGA, TOP1, SYP, ENO2
27potassium44 11 2411.2SYP, NTRK1, ENO2, VIP, ADM, S100B
28haloperidol44 28 2 49 1113.2SYP, HCRT, ABCB1, TH, NPY, HTR1A
29formaldehyde44 2410.2NPY, CD44, CHGA, SYP, TOP1, S100B
30gaba449.2HCRT, CHGA, NPY, VIP, TH, ENO2
31glucose449.2HCRT, GALP, ADM, DLK1, NPY, CD44
325-hydroxytryptamine449.1VIP, HTR1A, SYP, CHGA, HCRT, TH
33acetylcholine44 49 28 11 2413.1ADM, CHGA, SYP, ENO2, TH, HCRT
34dopamine44 28 11 2412.0MYCN, HCRT, ENO2, TH, CHGA, NPY
35progesterone44 59 28 11 2413.0SYP, NTRK1, CD44, CHGA, ENO2, ABCB1
36alanine448.9NTRK1, NPY, TH, HCRT, CD44, ADM
37acth448.9HCRT, CHGA, ADM, SYP, NPY, HTR1A
38epinephrine44 11 2410.9VIP, NPY, CHGA, CBLN3, ABCB1, CD44
39paraffin448.9S100B, CHGA, SYP, ADM, ENO2, TH
40lactate448.9ADM, ENO2, TH, CD44, VIP, MYCN
41vegf448.8S100B, SYP, ADM, ENO2, TH, CD44
42retinoic acid44 249.8ENO2, NPY, S100B, CHGA, NTRK1, MYCN
43cisplatin44 49 59 1111.7ABCB1, ENO2, TOP1, SYP, CHGA, MYCN
44nitric oxide44 11 2410.6HCRT, NPY, ADM, S100B, VIP, MYCN
45cyclic amp44 249.6NPY, DLK1, CD44, HCRT, NTRK1, CHGA
46adenylate448.5VIP, NPY, CHGA, NTRK1, HCRT, CD44
47norepinephrine44 11 2410.4ENO2, ADM, VIP, S100B, HTR1A, NPY
48testosterone44 59 11 2411.4CD44, VIP, S100B, NPY, NTRK1, CHGA
49catecholamine448.4CHGA, NTRK1, MYCN, HCRT, TH, ENO2
50tyrosine448.1VIP, CHGA, SYP, NPY, S100B, ADM

GO Terms for genes affiliated with Ganglioneuroblastoma

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16Gene Ontology
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Cellular components related to Ganglioneuroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmic vesicleGO:0314109.9TH, DLL1, NTRK1
2perikaryonGO:0432049.7TOP1, TH, ENO2
3extracellular regionGO:0055768.5VIP, S100B, NPY, GALP, CHGA, HCRT

Biological processes related to Ganglioneuroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular response to nicotineGO:07131610.1TH, NTRK1
2response to nutrient levelsGO:03166710.1TH, NTRK1
3learning or memoryGO:00761110.0NTRK1, S100B, VIP
4negative regulation of potassium ion transportGO:04326710.0VIP, HCRT
5neuropeptide signaling pathwayGO:0072189.6HCRT, GALP, NPY

Molecular functions related to Ganglioneuroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.8ADM, GALP, VIP

Products for genes affiliated with Ganglioneuroblastoma

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  • Antibodies
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Sources for Ganglioneuroblastoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet