MCID: GNG002
MIFTS: 48

Ganglioneuroma

Categories: Neuronal diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Ganglioneuroma

MalaCards integrated aliases for Ganglioneuroma:

Name: Ganglioneuroma 12 56 29 52 14 69

Classifications:

Orphanet: 56  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:4817
NCIt 47 C42065
Orphanet 56 ORPHA251992
UMLS via Orphanet 70 C0017075
ICD10 via Orphanet 34 D36.1
UMLS 69 C1513025

Summaries for Ganglioneuroma

MalaCards based summary : Ganglioneuroma is related to myoblastoma and neuroblastoma, and has symptoms including multiple intestinal neurofibromatosis, abnormality of the mediastinum and colorectal polyposis. An important gene associated with Ganglioneuroma is SYP (Synaptophysin), and among its related pathways/superpathways are Neuroscience and Brain-Derived Neurotrophic Factor (BDNF) signaling pathway. The drugs Bevacizumab and Irinotecan have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, colon and bone, and related phenotypes are Increased cell viability after pRB stimulation and behavior/neurological

Wikipedia : 72 Ganglioneuroma is a rare and benign tumor of the autonomic nerve fibers arising from neural crest... more...

Related Diseases for Ganglioneuroma

Diseases related to Ganglioneuroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 295)
id Related Disease Score Top Affiliating Genes
1 myoblastoma 29.9 ENO2 SYP
2 neuroblastoma 29.6 ENO2 MYCN NCAM1 NTRK1 NTRK2 SYP
3 pheochromocytoma 28.4 CHGA ENO2 NTRK1 RET SYP VIP
4 olfactory neuroblastoma 28.3 CHGA ENO2 NCAM1 SYP
5 cutaneous ganglioneuroma 12.0
6 multiple endocrine neoplasia iib 11.0
7 gangliocytoma 10.8
8 multiple endocrine neoplasia iia 10.8
9 central hypoventilation syndrome, congenital 10.8
10 appendix adenocarcinoma 10.8
11 2q31.1 microdeletion syndrome 10.7 ENO2 SYP
12 paranasal sinus cancer 10.7 ENO2 SYP
13 situs inversus totalis with cystic dysplasia of kidneys and pancreas 10.7 ENO2 SYP
14 bronchus adenoma 10.7 ENO2 SYP
15 pemphigus foliaceus 10.7 ENO2 SYP
16 skin papilloma 10.6 ENO2 SYP
17 hair disease 10.6 ENO2 SYP
18 hypogonadotropic hypogonadism-frontoparietal alopecia syndrome 10.6 GFAP SYP
19 thymus large cell carcinoma 10.6 ENO2 SYP
20 dystonia 10.6 GFAP SYP
21 mature teratoma 10.6 ENO2 SYP
22 chilaiditi syndrome 10.6 GFAP SYP
23 todd's paralysis 10.6 GFAP VIP
24 proliferative type fibrocystic change of breast 10.6 ENO2 SYP
25 cerebellar astrocytoma 10.6 GFAP SYP
26 epidermal appendage tumor 10.6 GFAP SYP
27 olfactory neural tumor 10.6 ENO2 SYP
28 hypogonadotropic hypogonadism-retinitis pigmentosa syndrome 10.6 GFAP SYP
29 sensory organ benign neoplasm 10.6 ENO2 SYP
30 adenofibroma 10.6 GFAP SYP
31 pleural empyema 10.6 GFAP SYP
32 anaplastic oligodendroglioma 10.6 GFAP SYP
33 spondyloepimetaphyseal dysplasia, isidor type 10.6 ENO2 SYP
34 alpha chain disease 10.6 ENO2 SYP
35 space motion sickness 10.6 GFAP SYP
36 papillary glioneuronal tumor 10.6 GFAP SYP
37 central neurocytoma 10.6 GFAP SYP
38 glomangioma 10.5 ENO2 SYP
39 neuritis 10.5 NCAM1 SYP
40 extracutaneous mastocytoma 10.5 ENO2 SYP
41 familial schizencephaly, shh-related 10.5 NTRK1 RET
42 migraine with aura 10.5 ENO2 SYP
43 meningitis and encephalitis 10.5 ENO2 GFAP
44 pneumothorax 10.5 GFAP SYP
45 adult oligodendroglioma 10.5 GFAP SYP
46 hypersensitivity reaction type iii disease 10.5 ENO2 SYP
47 intellectual disability-polydactyly-uncombable hair syndrome 10.5 ENO2 GFAP
48 sm-ahnmd 10.5 NCAM1 SYP
49 nodular medulloblastoma 10.5 ENO2 GFAP
50 malignant teratoma 10.5 NCAM1 SYP

Graphical network of the top 20 diseases related to Ganglioneuroma:



Diseases related to Ganglioneuroma

Symptoms & Phenotypes for Ganglioneuroma

Human phenotypes related to Ganglioneuroma:

56 32 (show all 16)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 ganglioneuroma 56 32 obligate (100%) Obligate (100%) HP:0003005
2 multiple intestinal neurofibromatosis 56 32 frequent (33%) Frequent (79-30%) HP:0005220
3 abnormality of the mediastinum 56 32 frequent (33%) Frequent (79-30%) HP:0045026
4 colorectal polyposis 56 32 frequent (33%) Frequent (79-30%) HP:0200063
5 hypertension 56 32 occasional (7.5%) Occasional (29-5%) HP:0000822
6 episodic abdominal pain 56 32 occasional (7.5%) Occasional (29-5%) HP:0002574
7 hamartomatous polyposis 56 32 occasional (7.5%) Occasional (29-5%) HP:0004390
8 functional intestinal obstruction 56 32 occasional (7.5%) Occasional (29-5%) HP:0005249
9 neoplasm of the adrenal gland 56 32 occasional (7.5%) Occasional (29-5%) HP:0100631
10 abnormality of the orbital region 56 32 very rare (1%) Very rare (<4-1%) HP:0000315
11 gastrointestinal hemorrhage 56 32 very rare (1%) Very rare (<4-1%) HP:0002239
12 abnormal bone structure 56 32 very rare (1%) Very rare (<4-1%) HP:0003330
13 central hypoventilation 56 32 very rare (1%) Very rare (<4-1%) HP:0007110
14 abnormality of the prostate 56 32 very rare (1%) Very rare (<4-1%) HP:0008775
15 abnormality of the adrenal glands 56 Frequent (79-30%)
16 abnormality of the rectum 56 Very rare (<4-1%)

UMLS symptoms related to Ganglioneuroma:


seizures

GenomeRNAi Phenotypes related to Ganglioneuroma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell viability after pRB stimulation GR00230-A-1 8.8 NTRK1 NTRK2 RET

MGI Mouse Phenotypes related to Ganglioneuroma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.96 ENO2 GALP GFAP MYCN NCAM1 NTRK1
2 growth/size/body region MP:0005378 9.76 CHGA ENO2 GALP GFAP MYCN NTRK1
3 nervous system MP:0003631 9.56 RET SYP ENO2 GFAP MYCN NCAM1
4 normal MP:0002873 9.17 GFAP MYCN NTRK1 NTRK2 RET SYP

Drugs & Therapeutics for Ganglioneuroma

Drugs for Ganglioneuroma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 1 216974-75-3
2
Irinotecan Approved, Investigational Phase 1 97682-44-5, 100286-90-6 60838
3
Camptothecin Experimental Phase 1 7689-03-4
4 Angiogenesis Inhibitors Phase 1
5 Angiogenesis Modulating Agents Phase 1
6 Antineoplastic Agents, Phytogenic Phase 1
7 topoisomerase I inhibitors Phase 1
8 Topoisomerase Inhibitors Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Evaluation of FDOPA-PET/MRI in Pediatric Patients With CNS Tumors Completed NCT01999270 Phase 1 Irinotecan;Bevacizumab
2 Prospective Study Registry of Peripheral Neuroblastic Tumours Presenting With Spinal Canal Involvement (SCI) Recruiting NCT02559804
3 International Congenital Central Hypoventilation Syndrome (CCHS) Registry Recruiting NCT03088020

Search NIH Clinical Center for Ganglioneuroma

Genetic Tests for Ganglioneuroma

Genetic tests related to Ganglioneuroma:

id Genetic test Affiliating Genes
1 Ganglioneuroma 29

Anatomical Context for Ganglioneuroma

MalaCards organs/tissues related to Ganglioneuroma:

39
Adrenal Gland, Colon, Bone, Prostate, Spinal Cord, Pituitary, Skin

Publications for Ganglioneuroma

Articles related to Ganglioneuroma:

(show top 50) (show all 595)
id Title Authors Year
1
Ganglioneuroma of the retropharyngeal space in a patient with glottic cancer. ( 28882936 )
2017
2
De Novo Tumors of Teratoma: Ganglioneuroma Arising From a Mature Cystic Teratoma of the Ovary. ( 28700440 )
2017
3
Case report: Robot-assisted laparoscopic excision of giant ganglioneuroma of the adrenal gland. ( 28748502 )
2017
4
Giant Ganglioneuroma in a 5-Year Child. ( 28302232 )
2017
5
Harlequin Syndrome Following Resection of Mediastinal Ganglioneuroma. ( 28382275 )
2017
6
Uveal Ganglioneuroma due to Germline PTEN Mutation (Cowden Syndrome) Presenting as Unilateral Infantile Glaucoma. ( 28868283 )
2017
7
Robotic assisted laparoscopic excision of a retroperitoneal Ganglioneuroma. ( 28537695 )
2017
8
Excision of a Presacral Ganglioneuroma in a Young Man. ( 28738920 )
2017
9
A Case Report of Giant Adrenal Ganglioneuroma. ( 28443238 )
2017
10
Adrenal ganglioneuroma: The Padua Endocrine Surgery Unit experience. ( 28506406 )
2017
11
Composite Pheochromocytoma/Paraganglioma-Ganglioneuroma: A Clinicopathologic Study of Eight Cases with Analysis of Succinate Dehydrogenase. ( 28752484 )
2017
12
Ganglioneuroma of the External Auditory Canal and Middle Ear. ( 28875046 )
2017
13
Retroperitoneal Ganglioneuroma Mimicking a Kidney Tumor. Case Report. ( 28607627 )
2017
14
Surgical management and outcomes of ganglioneuroma and ganglioneuroblastoma-intermixed. ( 28608056 )
2017
15
Appendiceal ganglioneuroma in neurofibromatosis type 2. ( 28578246 )
2017
16
Trigeminal Ganglioneuroma in the Middle-posterior Cranial Fossa: a Case Report. ( 28693694 )
2017
17
Intrathoracic ganglioneuroma presenting as an endobronchial mass. ( 28879079 )
2017
18
Giant Ganglioneuroma of Thoracic Spine: A Case Report and Review of Literature. ( 28490166 )
2017
19
Bilateral pheochromocytoma with ganglioneuroma component associated with multiple neuroendocrine neoplasia type 2A: a case report. ( 28760150 )
2017
20
Images in Endocrine Pathology: Unique Composite Adrenal Adenomatoid Tumor, Ganglioneuroma, Myelolipoma, and Cortical Nodular Hyperplasia. ( 28382483 )
2017
21
Composite paraganglioma-ganglioneuroma concomitant with adrenal metastasis of medullary thyroid carcinoma in a patient with multiple endocrine neoplasia type 2B: A case report. ( 27704704 )
2017
22
Ganglioneuroma of the pancreas in a 4-year-old girl. ( 27873762 )
2016
23
Organ Preservation in a Case of Retroperitoneal Ganglioneuroma: A Case Report and Review of Literature. ( 27668117 )
2016
24
Thoracolumbar paravertebral giant ganglioneuroma and scoliosis: a case report and literature review. ( 26946494 )
2016
25
Treatment and outcome of Ganglioneuroma and Ganglioneuroblastoma intermixed. ( 27465021 )
2016
26
Role of radiotherapy in adult ganglioneuroblastoma and ganglioneuroma. ( 27569100 )
2016
27
Adrenal Collision Tumor: Coexistence of Pigmented Adrenal Cortical Oncocytoma and Ganglioneuroma. ( 28053800 )
2016
28
Retroperitoneal paravertebral ganglioneuroma: a multidisciplinary approach facilitates less radical surgery. ( 27461001 )
2016
29
A case of pediatric parapharyngeal space ganglioneuroma. ( 27140023 )
2016
30
Ciliochoroidal ganglioneuroma in neurofibromatosis type 1: Report of a case and review of the literature. ( 26970398 )
2016
31
Thyroid, Renal, and Breast Carcinomas, Chondrosarcoma, Colon Adenomas, and Ganglioneuroma: A New Cancer Syndrome, FAP, or Just Coincidence. ( 27087812 )
2016
32
Spontaneous Maturation of Neuroblastoma to Ganglioneuroma: Two Case Studies. ( 27362946 )
2016
33
Adrenal ganglioneuroma in a pregnant woman. ( 27364185 )
2016
34
Clinicopathological Features of Ganglioneuroma Originating From the Adrenal Glands. ( 27431319 )
2016
35
Extradural ganglioneuroma with T1-T2 involvement mimicking spondylodiscitis: a case report and a review of the literature. ( 27813619 )
2016
36
What Do We Need to Know About Colonic Polypoid Ganglioneuroma? A Case Report and A Comprehensive Review. ( 27888390 )
2016
37
Intermittent Fever, Progressive Weight Gain, and Personality Changes in a Five-Year-Old Girl: Unusual Paraneoplastic Syndrome due to Presacral Ganglioneuroma. ( 27413558 )
2016
38
Ganglioneuroma of the lumbar spine presenting with scoliosis in a 7-year-old child. ( 27012649 )
2016
39
Tips to facilitate a preoperative diagnosis of adrenal ganglioneuroma. Report of a challenging experience and review of the literature. ( 27595615 )
2016
40
Diagnostic imaging findings of pelvic retroperitoneal ganglioneuroma in a child: a case report with the emphasis on initial ultrasound findings. ( 26962565 )
2016
41
Trigeminal Ganglioneuroma: A rare cause of trigeminal neuralgia caused by cerebello-pontine angle tumor. ( 28043883 )
2016
42
Advanced MRI manifestations of trigeminal ganglioneuroma: a case report and literature review. ( 27576442 )
2016
43
A case of colonic solitary polypoid ganglioneuroma with a feature of inverted hyperplastic polyp. ( 25846770 )
2015
44
Laparoscopic resection of primary adrenal ganglioneuroma: A case report and review of the literature. ( 26137033 )
2015
45
Cervical ganglioneuroma in collision with a metastatic undifferentiated carcinoma. ( 26097314 )
2015
46
Lumbar Spinal Immature Ganglioneuroma with Conus Medullaris Invasion: Case Report. ( 26461185 )
2015
47
Conus medullaris ganglioneuroma with syringomyelia radiologically mimicking ependymoma: A case report. ( 26788212 )
2015
48
Retroperitoneal catecholamine-producing ganglioneuroma with a birth history of monozygotic twins who both suffered from neuroblastoma during their childhoods: A case report with genome analysis. ( 26248704 )
2015
49
Solitary Colonic Ganglioneuroma: A Rare Incidental Finding of Hematochezia. ( 26075113 )
2015
50
Incidentally found retroperitoneal ganglioneuroma in an adult. ( 25972626 )
2015

Variations for Ganglioneuroma

Expression for Ganglioneuroma

Search GEO for disease gene expression data for Ganglioneuroma.

Pathways for Ganglioneuroma

Pathways related to Ganglioneuroma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.79 ENO2 GFAP MYCN NCAM1 NTRK1 NTRK2
2 11.66 NCAM1 NTRK1 NTRK2
3 11.59 NTRK1 NTRK2 RET
4 11.03 GFAP NCAM1 SYP
5
Show member pathways
10.2 NTRK1 NTRK2

GO Terms for Ganglioneuroma

Cellular components related to Ganglioneuroma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 8.8 NTRK1 NTRK2 RET

Biological processes related to Ganglioneuroma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 axon guidance GO:0007411 9.58 NCAM1 NTRK1 RET
2 peptidyl-tyrosine phosphorylation GO:0018108 9.54 NTRK1 NTRK2 RET
3 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.43 NTRK1 NTRK2 RET
4 positive regulation of neuron projection development GO:0010976 9.33 NTRK1 NTRK2 RET
5 innervation GO:0060384 9.32 NTRK1 RET
6 mechanoreceptor differentiation GO:0042490 8.96 NTRK1 NTRK2
7 neurotrophin signaling pathway GO:0038179 8.62 NTRK1 NTRK2

Molecular functions related to Ganglioneuroma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.5 NTRK1 NTRK2 RET
2 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.33 NTRK1 NTRK2 RET
3 kinase binding GO:0019900 8.96 NTRK1
4 neurotrophin binding GO:0043121 8.96 NTRK1 NTRK2
5 neurotrophin receptor activity GO:0005030 8.62 NTRK1 NTRK2

Sources for Ganglioneuroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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