MCID: GNG002
MIFTS: 47

Ganglioneuroma malady

Categories: Neuronal diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Ganglioneuroma

Aliases & Descriptions for Ganglioneuroma:

Name: Ganglioneuroma 12 56 29 52 14 69

Classifications:

Orphanet: 56  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:4817
NCIt 47 C42065
Orphanet 56 ORPHA251992
UMLS via Orphanet 70 C0017075
ICD10 via Orphanet 34 D36.1
UMLS 69 C1513025

Summaries for Ganglioneuroma

MalaCards based summary : Ganglioneuroma is related to neuroblastoma and pheochromocytoma, and has symptoms including hypertension, gastrointestinal hemorrhage and episodic abdominal pain. An important gene associated with Ganglioneuroma is SYP (Synaptophysin), and among its related pathways/superpathways are Neuroscience and Brain-Derived Neurotrophic Factor (BDNF) signaling pathway. The drugs Irinotecan and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, colon and bone, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : 71 Ganglioneuroma is a rare and benign tumor of the autonomic nerve fibers arising from neural crest... more...

Related Diseases for Ganglioneuroma

Diseases related to Ganglioneuroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 272)
id Related Disease Score Top Affiliating Genes
1 neuroblastoma 31.1 ENO2 MYCN NCAM1 NTRK1 NTRK2 SYP
2 pheochromocytoma 29.5 CHGA ENO2 NTRK1 SST SYP VIP
3 olfactory neuroblastoma 29.5 GFAP SYP
4 cutaneous ganglioneuroma 12.1
5 gangliocytoma 11.0
6 multiple endocrine neoplasia iib 10.9
7 multiple endocrine neoplasia iia 10.8
8 central hypoventilation syndrome, congenital 10.8
9 appendix adenocarcinoma 10.8
10 spinal chordoma 10.3 NCAM1 SYP
11 hypoparathyroidism-intellectual disability-dysmorphism syndrome 10.3 NCAM1 SYP
12 movement disease 10.3 NCAM1 SYP
13 ovarian germ cell teratoma 10.3 NCAM1 SYP
14 infiltrating renal pelvis transitional cell carcinoma 10.3 ENO2 SYP
15 skeletal-extraskeletal angiomatosis 10.3 ENO2 SYP
16 uterine corpus sarcoma 10.3 ENO2 NCAM1
17 cavernous hemangioma of colon 10.3 ENO2 NCAM1
18 autosomal recessive stickler syndrome 10.3 ENO2 SYP
19 gastric teratoma 10.2 ENO2 NCAM1
20 papillary tumor of the pineal region 10.2 GFAP SYP
21 pilocytic astrocytoma of cerebellum 10.2 GFAP SYP
22 children's interstitial lung disease 10.2 GFAP SYP
23 cervical benign neoplasm 10.2 GFAP SYP
24 myxopapillary ependymoma 10.2 GFAP SYP
25 epidermal appendage tumor 10.2 GFAP SYP
26 glycogen storage disease due to glycogen branching enzyme deficiency 10.2 GFAP VIP
27 clear cell meningioma 10.2 GFAP SYP
28 uterine corpus endometrial carcinoma 10.2 MYCN VIP
29 mucinous stomach adenocarcinoma 10.2 MYCN VIP
30 paternal uniparental disomy of chromosome 1 10.2 GFAP SYP
31 cerebral folate receptor alpha deficiency 10.2 GFAP SYP
32 vulvar benign neoplasm 10.2 GFAP SYP
33 adenofibroma 10.2 GFAP SYP
34 pilocytic astrocytoma 10.2 GFAP SYP
35 behcet's syndrome arthropathy 10.2 GFAP SYP
36 aneurysm of sinus of valsalva 10.2 GFAP SYP
37 male reproductive system disease 10.2 GFAP SYP
38 sternum cancer 10.2 GFAP NCAM1
39 postgastrectomy syndrome 10.2 SST SYP
40 pleomorphic xanthoastrocytoma 10.2 GFAP SYP
41 mediastinal granular cell myoblastoma 10.2 GFAP SYP
42 gall bladder carcinoma in situ 10.2 MYCN NTRK1
43 central neurocytoma 10.2 GFAP SYP
44 mast-cell sarcoma 10.2 GFAP SYP
45 wells-jankovic syndrome 10.2 SST VIP
46 hypogonadotropic hypogonadism-retinitis pigmentosa syndrome 10.2 GFAP SYP
47 myelinoclastic diffuse sclerosis 10.2 ENO2 GFAP
48 tooth agenesis, selective, 5 10.2 NCAM1 SYP VIP
49 glomus tumor 10.2 ENO2 NCAM1 SYP
50 ampullary signet ring cell adenocarcinoma 10.2 ENO2 NCAM1 SYP

Graphical network of the top 20 diseases related to Ganglioneuroma:



Diseases related to Ganglioneuroma

Symptoms & Phenotypes for Ganglioneuroma

Human phenotypes related to Ganglioneuroma:

56 32 (show all 16)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hypertension 56 32 Occasional (29-5%) HP:0000822
2 gastrointestinal hemorrhage 56 32 Very rare (<4-1%) HP:0002239
3 episodic abdominal pain 56 32 Occasional (29-5%) HP:0002574
4 colorectal polyposis 56 32 Frequent (79-30%) HP:0200063
5 hamartomatous polyposis 56 32 Occasional (29-5%) HP:0004390
6 central hypoventilation 56 32 Very rare (<4-1%) HP:0007110
7 abnormal bone structure 56 32 Very rare (<4-1%) HP:0003330
8 functional intestinal obstruction 56 32 Occasional (29-5%) HP:0005249
9 ganglioneuroma 56 32 Obligate (100%) HP:0003005
10 neoplasm of the adrenal gland 56 32 Occasional (29-5%) HP:0100631
11 abnormality of the mediastinum 56 32 Frequent (79-30%) HP:0045026
12 multiple intestinal neurofibromatosis 56 32 Frequent (79-30%) HP:0005220
13 abnormality of the orbital region 56 32 Very rare (<4-1%) HP:0000315
14 abnormality of the prostate 56 32 Very rare (<4-1%) HP:0008775
15 abnormality of the adrenal glands 56 Frequent (79-30%)
16 abnormality of the rectum 56 Very rare (<4-1%)

UMLS symptoms related to Ganglioneuroma:


seizures

MGI Mouse Phenotypes related to Ganglioneuroma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.96 NCAM1 NTRK1 NTRK2 SST SYP VIP
2 growth/size/body region MP:0005378 9.76 SST CHGA ENO2 GALP GFAP MYCN
3 nervous system MP:0003631 9.56 ENO2 GFAP MYCN NCAM1 NTRK1 NTRK2
4 normal MP:0002873 9.17 GFAP MYCN NTRK1 NTRK2 SST SYP

Drugs & Therapeutics for Ganglioneuroma

Drugs for Ganglioneuroma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Irinotecan Approved, Investigational Phase 1 97682-44-5, 100286-90-6 60838
2
Bevacizumab Approved, Investigational Phase 1 216974-75-3
3
Camptothecin Experimental Phase 1 7689-03-4
4 topoisomerase I inhibitors Phase 1
5 Topoisomerase Inhibitors Phase 1
6 Angiogenesis Inhibitors Phase 1
7 Angiogenesis Modulating Agents Phase 1
8 Antineoplastic Agents, Phytogenic Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase
1 Evaluation of FDOPA-PET/MRI in Pediatric Patients With CNS Tumors Completed NCT01999270 Phase 1
2 Prospective Study Registry of Peripheral Neuroblastic Tumours Presenting With Spinal Canal Involvement (SCI) Recruiting NCT02559804
3 International Congenital Central Hypoventilation Syndrome (CCHS) Registry Recruiting NCT03088020

Search NIH Clinical Center for Ganglioneuroma

Genetic Tests for Ganglioneuroma

Genetic tests related to Ganglioneuroma:

id Genetic test Affiliating Genes
1 Ganglioneuroma 29

Anatomical Context for Ganglioneuroma

MalaCards organs/tissues related to Ganglioneuroma:

39
Adrenal Gland, Colon, Bone, Prostate, Spinal Cord, Small Intestine, Pituitary

Publications for Ganglioneuroma

Articles related to Ganglioneuroma:

(show top 50) (show all 575)
id Title Authors Year
1
Composite paraganglioma-ganglioneuroma concomitant with adrenal metastasis of medullary thyroid carcinoma in a patient with multiple endocrine neoplasia type 2B: A case report. ( 27704704 )
2017
2
Trigeminal Ganglioneuroma: A rare cause of trigeminal neuralgia caused by cerebello-pontine angle tumor. ( 28043883 )
2016
3
Treatment and outcome of Ganglioneuroma and Ganglioneuroblastoma intermixed. ( 27465021 )
2016
4
Advanced MRI manifestations of trigeminal ganglioneuroma: a case report and literature review. ( 27576442 )
2016
5
Intermittent Fever, Progressive Weight Gain, and Personality Changes in a Five-Year-Old Girl: Unusual Paraneoplastic Syndrome due to Presacral Ganglioneuroma. ( 27413558 )
2016
6
Organ Preservation in a Case of Retroperitoneal Ganglioneuroma: A Case Report and Review of Literature. ( 27668117 )
2016
7
Extradural ganglioneuroma with T1-T2 involvement mimicking spondylodiscitis: a case report and a review of the literature. ( 27813619 )
2016
8
Tips to facilitate a preoperative diagnosis of adrenal ganglioneuroma. Report of a challenging experience and review of the literature. ( 27595615 )
2016
9
Adrenal ganglioneuroma in a pregnant woman. ( 27364185 )
2016
10
What Do We Need to Know About Colonic Polypoid Ganglioneuroma? A Case Report and A Comprehensive Review. ( 27888390 )
2016
11
Clinicopathological Features of Ganglioneuroma Originating From the Adrenal Glands. ( 27431319 )
2016
12
Retroperitoneal paravertebral ganglioneuroma: a multidisciplinary approach facilitates less radical surgery. ( 27461001 )
2016
13
Role of radiotherapy in adult ganglioneuroblastoma and ganglioneuroma. ( 27569100 )
2016
14
Ciliochoroidal ganglioneuroma in neurofibromatosis type 1: Report of a case and review of the literature. ( 26970398 )
2016
15
Spontaneous Maturation of Neuroblastoma to Ganglioneuroma: Two Case Studies. ( 27362946 )
2016
16
Ganglioneuroma of the lumbar spine presenting with scoliosis in a 7-year-old child. ( 27012649 )
2016
17
Ganglioneuroma of the pancreas in a 4-year-old girl. ( 27873762 )
2016
18
Diagnostic imaging findings of pelvic retroperitoneal ganglioneuroma in a child: a case report with the emphasis on initial ultrasound findings. ( 26962565 )
2016
19
Adrenal Collision Tumor: Coexistence of Pigmented Adrenal Cortical Oncocytoma and Ganglioneuroma. ( 28053800 )
2016
20
A case of pediatric parapharyngeal space ganglioneuroma. ( 27140023 )
2016
21
Thoracolumbar paravertebral giant ganglioneuroma and scoliosis: a case report and literature review. ( 26946494 )
2016
22
Thyroid, Renal, and Breast Carcinomas, Chondrosarcoma, Colon Adenomas, and Ganglioneuroma: A New Cancer Syndrome, FAP, or Just Coincidence. ( 27087812 )
2016
23
Malignant peripheral nerve sheath tumour arising de novo from ganglioneuroma. ( 26352113 )
2015
24
Cervical ganglioneuroma in collision with a metastatic undifferentiated carcinoma. ( 26097314 )
2015
25
Lumbar Spinal Immature Ganglioneuroma with Conus Medullaris Invasion: Case Report. ( 26461185 )
2015
26
Immature ganglioneuroma of the thoracic spine with lipomatous component: a rare cause of scoliosis. ( 26096483 )
2015
27
Solitary Colonic Ganglioneuroma: A Rare Incidental Finding of Hematochezia. ( 26075113 )
2015
28
Conus medullaris ganglioneuroma with syringomyelia radiologically mimicking ependymoma: A case report. ( 26788212 )
2015
29
Incidentally found retroperitoneal ganglioneuroma in an adult. ( 25972626 )
2015
30
Retroperitoneal ganglioneuroma revealed as an "incidentaloma" in a healthy volunteer. ( 25543149 )
2015
31
Bladder ganglioneuroma in a 5-year-old girl presenting with a urinary tract infection and hematuria: case report and review of the literature. ( 25623721 )
2015
32
Laparoscopic resection of primary adrenal ganglioneuroma: A case report and review of the literature. ( 26137033 )
2015
33
C1-2 ganglioneuroma in a patient with neurofibromatosis type-1. ( 26448250 )
2015
34
The polypoid ganglioneuroma associated with hyperplastic polyposis. ( 26712574 )
2015
35
Retroperitoneal catecholamine-producing ganglioneuroma with a birth history of monozygotic twins who both suffered from neuroblastoma during their childhoods: A case report with genome analysis. ( 26248704 )
2015
36
Ganglioneuroma arising from the L5 nerve root: A rare case report. ( 26396615 )
2015
37
Renal Ganglioneuroma Presenting as an Apparent Renal Artery Aneurysm. ( 26793512 )
2015
38
Mature ganglioneuroma of the adrenal gland as a new rare cause of visible haematuria: A case report & literature review. ( 26196309 )
2015
39
A case of colonic solitary polypoid ganglioneuroma with a feature of inverted hyperplastic polyp. ( 25846770 )
2015
40
Jugular Foramen Ganglioneuroma Presenting Radiographically as Schwannoma. ( 26485601 )
2015
41
Retroperitoneal Ganglioneuroma: Mimicking an ovarian mass in a child. ( 26150876 )
2015
42
Unsuspected Ganglioneuroma of the Choroid Diagnosed after Enucleation. ( 27171204 )
2015
43
Diverse proportion in composite pheochromocytoma-ganglioneuroma may induce varied clinical symptom: comparison of two cases. ( 26823896 )
2015
44
Cardiac ganglioneuroma in a juvenile pig. ( 26256406 )
2015
45
Coexistence of neuroblastoma and ganglioneuroma in a girl with a hemizygous deletion of chromosome 11q14.1-23.3. ( 26463893 )
2015
46
Childhood onset of acquired neuromyotonia: Association with a ganglioneuroma. ( 25619962 )
2015
47
Non-Functional Adrenal Gland Ganglioneuroma Masquerading as Chronic Calculus Cholecystitis. ( 27608876 )
2015
48
Exome Sequencing Reveals Germline SMAD9 Mutation That Reduces Phosphatase and Tensin Homolog Expression and Is Associated With Hamartomatous Polyposis and Gastrointestinal Ganglioneuromas. ( 26122142 )
2015
49
Case report: Large adrenal ganglioneuroma. ( 24709621 )
2014
50
Choroidal Ganglioneuroma and Orbital Plexiform Neurofibroma Presenting as Buphthalmos in an Infant With Neurofibromatosis Type 1. ( 25186217 )
2014

Variations for Ganglioneuroma

Expression for Ganglioneuroma

Search GEO for disease gene expression data for Ganglioneuroma.

Pathways for Ganglioneuroma

Pathways related to Ganglioneuroma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.74 ENO2 GFAP MYCN NCAM1 NTRK1 NTRK2
2 11.59 NCAM1 NTRK1 NTRK2
3 11.03 GFAP NCAM1 SYP
4
Show member pathways
10.2 NTRK1 NTRK2

GO Terms for Ganglioneuroma

Biological processes related to Ganglioneuroma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 mechanoreceptor differentiation GO:0042490 8.96 NTRK1 NTRK2
2 neurotrophin signaling pathway GO:0038179 8.62 NTRK1 NTRK2

Molecular functions related to Ganglioneuroma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.33 GALP SST VIP
2 neurotrophin binding GO:0043121 8.96 NTRK1 NTRK2
3 neurotrophin receptor activity GO:0005030 8.62 NTRK1 NTRK2

Sources for Ganglioneuroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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