MCID: GSG001
MIFTS: 66

Gas Gangrene malady

Infectious diseases category

Summaries for Gas Gangrene

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Gangrene is the death of tissues in your body. it happens when a part of your body loses its blood supply. gangrene can happen on the surface of the body, such as on the skin, or inside the body, in muscles or organs. causes include serious injuries problems with blood circulation, such as atherosclerosis and peripheral arterial disease diabetes skin symptoms may include a blue or black color, pain, numbness, and sores that produce a foul-smelling discharge. if the gangrene is internal, you may run a fever and feel unwell, and the area may be swollen and painful. gangrene is a serious condition. it needs immediate attention. treatment includes surgery, antibiotics, and oxygen therapy. in severe cases an amputation may be necessary.

MalaCards: Gas Gangrene, also known as gangrene, is related to adenocarcinoma and leukemia, and has symptoms including sepsis, gas production and myonecrosis. An important gene associated with Gas Gangrene is HSPG2 (heparan sulfate proteoglycan 2), and among its related pathways are Muscular Dystrophies and Dystrophin-Glycoprotein Complex and Non-integrin membrane-ECM interactions. The drugs nitrofurazone and oxygen and the compounds guanidino and phosphatidyl ethanol have been mentioned in the context of this disorder. Affiliated tissues include muscle tissue, skin and liver, and related mouse phenotypes are cardiovascular system and muscle.

Disease Ontology:8 A commensal bacterial infectious disease that results in infection, located in muscle tissue, has material basis in clostridium perfringens, which produce gas that becomes trapped in the infected tissue. gas gangrene usually develops after injuries or surgery. the infection has symptom large blisters, has symptom pain in the infected area, has symptom myonecrosis, has symptom gas production, and has symptom sepsis.

Wikipedia:63 Gas gangrene (also known as \"Clostridial myonecrosis\", and \"Myonecrosis\") is a bacterial infection... more...

Aliases & Classifications for Gas Gangrene

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
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Related Diseases for Gas Gangrene

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17GeneCards, 18GeneDecks
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Diseases related to Gas Gangrene via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 265)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.6PLA2G2A, HSPG2
2leukemia30.4PLA2G2A, ITGA2B, DMD
3diabetes mellitus30.4PIK3C2A, ITGA2B, NEU1, INS
4myocarditis30.3TNNT2, TNNI3, DMD, CHKB
5antiphospholipid syndrome30.2HSPG2
6ischemia30.1HSPG2, TNNT2, DMD, PIK3C2A, CHKB, PLA2G2A
7acute pancreatitis30.1PLA2G1B, PLA2G2A
8acute myocardial infarction30.1CHKB, ITGA2B, PIK3C2A, TNNI3, TNNT2
9myocardial infarction30.0CHKB, ITGA2B, PIK3C2A, TNNI3, TNNT2
10vascular disease30.0TNNT2, TNNI3, PIK3C2A
11pneumonia30.0HSPG2, PIK3C2A, NEU1, PLA2G1B
12atherosclerosis30.0HSPG2, ITGA2B, INS, PLA2G2A, PLA2G1B
13primary hyperoxaluria30.0INS, PIK3C2A, TNNI3, TNNT2
14hypertrophic cardiomyopathy29.8TNNI3, TNNT2
15neuropathy29.8INS, PIK3C2A, DMD
16myopathy29.8CASQ2, CASQ1, TNNT2, TNNI3, DMD, PIK3C2A
17muscular dystrophy29.8CHKB, PIK3C2A, DMD
18duchenne muscular dystrophy29.8TNNT2, TNNI3, DMD, PIK3C2A, CHKB
19myositis29.6DMD, PIK3C2A, CHKB
20panophthalmitis10.5
21burns10.4
22necrotizing fasciitis10.4
23fasciitis10.4
24hepatitis10.4
25tetanus10.4
26cholecystitis10.4
27noma10.3
28meckel's diverticulum10.3
29purpura10.3
30peritonitis10.3
31calciphylaxis10.3
32appendicitis10.2
33malaria10.2
34fournier gangrene10.2
35emphysematous cholecystitis10.2
36cecum adenocarcinoma10.2
37colon adenocarcinoma10.2
38colon cancer10.2
39esophagitis10.2
40liver cirrhosis10.2
41pancreatitis10.2
42plasmodium malariae malaria10.2
43acalculous cholecystitis10.2
44disseminated intravascular coagulation10.2
45mastitis10.2
46abdominal wall defect10.2
47cryoglobulinemia10.1
48polyarteritis nodosa10.1
49plasmodium falciparum malaria10.1
50vasculitis10.1

Graphical network of the top 20 diseases related to Gas Gangrene:



Diseases related to gas gangrene

Clinical Features for Gas Gangrene

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Sources:
8Disease Ontology
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Symptoms:

8
  • sepsis
  • gas production
  • myonecrosis
  • pain in the infected area
  • large blisters

Drugs & Therapeutics for Gas Gangrene

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Gas Gangrene

Drug clinical trials:

Search ClinicalTrials for Gas Gangrene

Search NIH Clinical Center for Gas Gangrene

Search CenterWatch for Gas Gangrene

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Gas Gangrene cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Gas Gangrene:
Peripheral blood-derived hematopoietic stem cells for leg gangrene
Embryonic/Adult Cultured Cells Related to Gas Gangrene:
Peripheral blood-derived hematopoietic stem cells

Genetic Tests for Gas Gangrene

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Anatomical Context for Gas Gangrene

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Gas Gangrene:

32
Skin, Liver, Colon, Uterus, Bone, Pancreas, Brain, Heart, Eye, Small intestine, Breast, Skeletal muscle, Monocytes, Appendix, Bone marrow, Spleen, Lung

FMA organs/tissues related to Gas Gangrene:

14
Muscle tissue

Animal Models for Gas Gangrene or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Gas Gangrene:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053857.9HSPG2, CASQ2, TNNT2, TNNI3, DMD, ITGA2B
2MP:00053697.6INS, HSPG2, CASQ2, CASQ1, TNNT2, TNNI3
3MP:00053767.0HSPG2, CASQ2, TNNT2, DMD, PIK3C2A, ITGA2B
4MP:00053786.9CASQ1, TNNT2, DMD, PIK3C2A, RBM12, NEU1

Publications for Gas Gangrene

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Sources:
50PubMed
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Articles related to Gas Gangrene:

(show top 50)    (show all 502)
idTitleAuthorsYear
1
Fatal massive infectious gas gangrene in a liver transplant recipient. (24415557)
2014
2
Management of gas gangrene in Wenchuan earthquake victims. (21336729)
2011
3
Subcutaneous emphysema of the penis and scrotum mimicking gas gangrene: a rare complication of ERCP. (20970792)
2011
4
Pneumorachis caused by metastatic gas gangrene. (19004591)
2009
5
Clostridium perfringens intestinal gas gangrene in a preterm newborn. (19224438)
2009
6
Cross-complementation of Clostridium perfringens PLC and Clostridium septicum alpha-toxin mutants reveals PLC is sufficient to mediate gas gangrene. (19284973)
2009
7
Metastatic gas gangrene. (17621855)
2007
8
Gas gangrene and necrotizing fasciitis in the upper extremity. (15281401)
2004
9
Spontaneous gas gangrene in malignant lymphoma: an underreported complication? (12111788)
2002
10
Spontaneous bifocal Clostridium septicum gas gangrene. (11380147)
2001
11
Spontaneous gas gangrene due to Clostridium perfringens. (10028101)
1999
12
Nonclostridial gas gangrene due to Streptococcus anginosus in a diabetic patient. (10025866)
1999
13
Use of genetically manipulated strains of Clostridium perfringens reveals that both alpha-toxin and theta-toxin are required for vascular leukostasis to occur in experimental gas gangrene. (10456947)
1999
14
Clostridial gas gangrene of the abdominal wall after laparoscopic cholecystectomy. (9448120)
1997
15
CT of pancreatic gas gangrene. (8838895)
1996
16
An unusual presentation of gas gangrene complicated by penicillin allergy. (7848804)
1994
17
Clostridial gas gangrene associated with congenital generalized lipodystrophy: report of a case. (7780235)
1994
18
Gas gangrene from subcutaneous insulin administration. (8240568)
1993
19
Gas gangrene panophthalmitis is a rare condition that can occur following penetrating injury with retained intraocular foreign body. (1565874)
1992
20
Role of chelating agents in gas gangrene. (3563828)
1987
21
Spontaneous clostridia gas gangrene of uterus associated with endometrial malignancy. (3578439)
1987
22
Fatal nonclostridial gas gangrene in a diabetic: a case report and review of the literature. (3798149)
1986
23
Isolation of Clostridium pseudotetanicum from a patient with gas gangrene. (6630439)
1983
24
Gas gangrene and hyperbaric oxygen therapy. (6781318)
1981
25
Gas gangrene in intestinal angina. (7459601)
1981
26
Survival after major burn complicated by gas gangrene, acute renal failure, and toxic myocarditis. (435749)
1979
27
Treatment of gas gangrene. Interest of hyperbaric oxygen therapy. (920108)
1977
28
Gas gangrene infections of the small intestine, colon and rectum. (1253651)
1976
29
Proceedings: Post-operative gas gangrene managed by hyperbaric oxygen. (1141310)
1975
30
Gas gangrene. (4353508)
1973
31
Gas gangrene with tetanus. (5057281)
1972
32
Gas gangrene and hyperbaric oxygen. (5078421)
1972
33
Gas gangrene. (5124058)
1971
34
Gas gangrene panophthalmitis. (5550537)
1971
35
Combined therapy in post-operative gas gangrene. (4318554)
1970
36
Gas gangrene: acute medical emergency; the role of hyperbaric oxygen. (5487383)
1970
37
Gas gangrene treated by hyperbaric oxygen. (5780645)
1969
38
Postoperative gas gangrene. (4305848)
1969
39
Gas gangrene of abdominal wall after appendectomy. (4393541)
1969
40
The toxins responsible for the lesions of Clostridium sordelli gas gangrene. (5821846)
1969
41
Gas gangrene after amputation for peripheral vascular disease. (5662196)
1968
42
Gas gangrene of the heart in clostridial septicemia. (6047770)
1967
43
Intra-arterial hydrogen peroxide in experimental gas-gangrene. (5595574)
1967
44
Postoperative gas gangrene. (4292680)
1967
45
Gas gangrene and mixed-clostridial infections of muscle complicating deep thermal burns. (5902850)
1966
46
Experimental clostridial wounds in rabbits. I. The effect of debridement delay, tetanus immunization, and topical antibiotics on the mortality from gas gangrene. (5941140)
1966
47
GAS GANGRENE COMPLICATION; REPORT OF A FATAL CASE FOLLOWING REMOVAL OF A SHELL SPLINTER FROM THE THIGH 22 YEARS AFTER WOUNDING. (14047533)
1963
48
Experimental gas gangrene: effect of clostridial and staphylococcal toxoids on survival time. (13740508)
1960
49
The x-ray diagnosis of gas gangrene of the uterus: report of a case. (13817173)
1960
50
Antemortem radiographic demonstration of gas gangrene of the liver. (13820110)
1960

Genetic Variations for Gas Gangrene

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Expression for genes affiliated with Gas Gangrene

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gas Gangrene

Search GEO for disease gene expression data for Gas Gangrene.

Pathways for genes affiliated with Gas Gangrene

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Sources:
51QIAGEN, 53Reactome, 29KEGG, 37NCBI BioSystems Database
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Compounds for genes affiliated with Gas Gangrene

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 2BitterDB, 59Tocris Bioscience, 49PharmGKB, 24HMDB
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Compounds related to Gas Gangrene according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1guanidino4410.2CHKB, NEU1
2phosphatidyl ethanol44 1111.2PLA2G2A, HSPG2
3alpha-hydroxybutyrate4410.1PIK3C2A, CHKB
4N-Tridecanoic Acid1110.0PLA2G1B, PLA2G2A
5thallium4410.0PIK3C2A, CHKB
6bw755c4410.0PLA2G2A, PLA2G1B
7scalaradial4410.0PLA2G2A, PLA2G1B
8dantrolene44 28 1111.9CHKB, PIK3C2A, HSPG2
9manoalide449.9HSPG2, PLA2G2A, PLA2G1B
10p-bromophenacyl bromide449.9PLA2G1B, PLA2G2A, HSPG2
111-oleoyl-2-acetyl-sn-glycerol449.9HSPG2, PLA2G2A, PLA2G1B
12aacocf3449.9HSPG2, PLA2G2A, PLA2G1B
13aristolochic acid44 210.9PLA2G1B, PLA2G2A, HSPG2
14ptca449.9CHKB, PIK3C2A, TNNT2
15quinacrine44 1110.8HSPG2, PLA2G2A, PLA2G1B
16melittin449.8PLA2G1B, PLA2G2A
17ndga449.8HSPG2, PLA2G2A, PLA2G1B
18edelfosine44 5910.8PLA2G1B, PLA2G2A, HSPG2
19gemfibrozil44 28 1111.8PIK3C2A, CHKB, INS
20bezafibrate44 28 1111.7PIK3C2A, CHKB, INS
21succinylcholine44 28 1111.7CHKB, PIK3C2A
22gamma-hydroxybutyrate449.7CHKB, PIK3C2A
23glibenclamide44 28 49 5912.7HSPG2, INS, PLA2G1B
24choline44 11 2411.6PLA2G2A, CHKB, PIK3C2A, HSPG2
25beta-hydroxybutyrate449.6INS, CHKB
26uric acid44 2410.6PIK3C2A, CHKB, INS
27myristic acid44 11 2411.5PLA2G1B, PLA2G2A, INS
28palmitate449.5HSPG2, INS, PLA2G2A
29phosphatidylcholine449.5HSPG2, NEU1, PLA2G2A, PLA2G1B
30ascorbic acid44 2410.5HSPG2, PIK3C2A, CHKB, PLA2G2A
31epinephrine44 11 2411.4PIK3C2A, CHKB, INS, PLA2G2A
32phospholipid449.3HSPG2, DMD, CHKB, PLA2G2A, PLA2G1B
33ly294002449.2HSPG2, PIK3C2A, INS, PLA2G2A
34melphalan44 1110.2IL4I1, CHKB, PIK3C2A
35acetylcholine44 49 28 11 2413.2HSPG2, DMD, PIK3C2A, NEU1, PLA2G2A
36glycogen44 2410.1TNNT2, DMD, PIK3C2A, CHKB, INS
37potassium44 11 2411.0PLA2G1B, CHKB, PIK3C2A, DMD, TNNI3
38dexamethasone44 49 28 1111.9HSPG2, CHKB, INS, PLA2G2A, PLA2G1B
39fatty acid448.7TNNT2, PIK3C2A, CHKB, INS, PLA2G2A, PLA2G1B
40fibrinogen448.7PIK3C2A, ITGA2B, CHKB, INS, IL4I1
41thromboxane a244 249.5HSPG2, PIK3C2A, IL4I1, PLA2G2A, PLA2G1B
42h2o2448.5HSPG2, NEU1, CHKB, IL4I1, PLA2G2A, PLA2G1B
43glycerol44 11 2410.4PLA2G1B, DMD, PIK3C2A, NEU1, CHKB, INS
44arginine448.3DMD, PIK3C2A, CHKB, INS, IL4I1, PLA2G2A
45heparin44 28 11 2411.2HSPG2, TNNT2, DMD, PIK3C2A, NEU1, CHKB
46serine448.1HSPG2, DMD, ITGA2B, NEU1, INS, IL4I1
47alanine447.8HSPG2, TNNT2, DMD, PIK3C2A, CHKB, INS
48creatinine447.8TNNT2, TNNI3, DMD, PIK3C2A, CHKB, INS
49lactate447.7TNNT2, TNNI3, PIK3C2A, CHKB, INS, IL4I1
50calcium44 49 11 2410.1HSPG2, CASQ2, CASQ1, TNNT2, TNNI3, DMD

GO Terms for genes affiliated with Gas Gangrene

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16Gene Ontology
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Cellular components related to Gas Gangrene according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1troponin complexGO:00586110.0TNNI3, TNNT2

Biological processes related to Gas Gangrene according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of ATPase activityGO:03278010.1TNNI3, TNNT2
2regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumGO:0108809.9DMD, CASQ2
3muscle filament slidingGO:0300499.9DMD, TNNI3, TNNT2
4cardiac muscle contractionGO:0600489.8DMD, TNNI3, CASQ2
5regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionGO:0108819.8CASQ2, DMD
6phosphatidylinositol acyl-chain remodelingGO:0361499.7PLA2G2A, PLA2G1B
7regulation of skeletal muscle contraction by regulation of release of sequestered calcium ionGO:0148099.7CASQ1, DMD
8phosphatidylethanolamine acyl-chain remodelingGO:0361529.7PLA2G1B, PLA2G2A
9glycerophospholipid biosynthetic processGO:0464749.6CHKB, PLA2G2A, PLA2G1B
10phosphatidylglycerol acyl-chain remodelingGO:0361489.6PLA2G1B, PLA2G2A
11phosphatidylserine acyl-chain remodelingGO:0361509.4PLA2G1B, PLA2G2A
12phospholipid metabolic processGO:0066449.1PLA2G1B, PLA2G2A, CHKB, PIK3C2A
13small molecule metabolic processGO:0442818.3HSPG2, PIK3C2A, NEU1, CHKB, INS, PLA2G2A

Molecular functions related to Gas Gangrene according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1troponin C bindingGO:03017210.0TNNI3, TNNT2
2phospholipase A2 activityGO:0046239.7PLA2G1B, PLA2G2A
3calcium-dependent phospholipase A2 activityGO:0474989.6PLA2G1B, PLA2G2A
4calcium ion bindingGO:0055098.1CASQ2, CASQ1, DMD, PLA2G2A, PLA2G1B

Products for genes affiliated with Gas Gangrene

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gas Gangrene

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet