MCID: GSG001
MIFTS: 53

Gas Gangrene malady

Categories: Infectious diseases, Skin diseases, Muscle diseases

Aliases & Classifications for Gas Gangrene

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Aliases & Descriptions for Gas Gangrene:

Name: Gas Gangrene 32 10 47 12 36 65
Myonecrosis 10 65
 
Gas Bacillus Infection or Gangrene 10
Gas Bacillus Infection 10

Classifications:



External Ids:

Disease Ontology10 DOID:9159
ICD1027 A48.0
ICD9CM29 040.0
MeSH36 D005738
UMLS65 C0017105, C0235957

Summaries for Gas Gangrene

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Disease Ontology:10 A commensal bacterial infectious disease that results in infection, located in muscle tissue, has material basis in Clostridium perfringens, which produce gas that becomes trapped in the infected tissue. Gas gangrene usually develops after injuries or surgery. The infection has symptom large blisters, has symptom pain in the infected area, has symptom myonecrosis, has symptom gas production, and has symptom sepsis.

MalaCards based summary: Gas Gangrene, also known as myonecrosis, is related to anthrax disease and neurofibroma of the heart, and has symptoms including large blisters, pain in the infected area and myonecrosis. An important gene associated with Gas Gangrene is HSPG2 (Heparan Sulfate Proteoglycan 2), and among its related pathways are Muscular Dystrophies and Dystrophin-Glycoprotein Complex and Antiarrhythmic Pathway, Pharmacodynamics. Affiliated tissues include muscle tissue, liver and heart, and related mouse phenotypes are cardiovascular system and muscle.

Wikipedia:68 Gas gangrene (also known as clostridial myonecrosis and myonecrosis) is a bacterial infection that... more...

Related Diseases for Gas Gangrene

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Diseases related to Gas Gangrene via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 83)
idRelated DiseaseScoreTop Affiliating Genes
1anthrax disease11.2
2neurofibroma of the heart10.4CASQ1, CASQ2
3progressive non-fluent aphasia10.3DMD, MB
4apical myocardial infarction10.2MB, TNNT2
5stormorken syndrome10.2CASQ1, CASQ2
6panophthalmitis10.2
7obesity due to prohormone convertase i deficiency10.2TNNI3, TNNT2
8neurological consequences of cytomegalovirus infection10.2DMD, HSPG2
9coronary thrombosis10.1TNNI3, TNNT2
10hepatitis10.1
11fasciitis10.1
12necrotizing fasciitis10.1
13transient retinal arterial occlusion10.1TNNI3, TNNT2
14burns10.1
15tetanus10.1
16adenocarcinoma10.1
17adrenal cortex disease10.1TNNI3, TNNT2
18peripheral artery disease10.0TNNI3, TNNT2
19cholecystitis10.0
20heart aneurysm10.0TNNI3, TNNT2
21meige syndrome10.0TNNI3, TNNT2
22infant gynecomastia10.0MB, TNNI3
23leukemia10.0
24peritonitis10.0
25withdrawal disorder9.9TNNI3, TNNT2
26liver cirrhosis9.9
27neutropenia9.9
28lymphoma9.9
29penicillin allergy9.9
30osteomyelitis9.9
31esophagitis9.9
32pancreatitis9.9
33myocarditis9.9
34emphysematous cholecystitis9.9
35transverse vaginal septum9.9DMD, TNNI3, TNNT2
36rh deficiency syndrome9.8TNNI3, TNNT2
37extrinsic cardiomyopathy9.8TNNI3, TNNT2
38specific developmental disorder9.8DMD, TNNI3, TNNT2
39drug-induced hepatitis9.7DMD, TNNI3, TNNT2
40lung cancer9.7
41breast cancer9.7
42obesity9.7
43bacteremia9.7
44leprosy9.7
45peripheral vascular disease9.7
46arthritis9.7
47atherosclerosis9.7
48crohn's disease9.7
49congenital generalized lipodystrophy9.7
50inguinal hernia9.7

Comorbidity relations with Gas Gangrene via Phenotypic Disease Network (PDN):


Peripheral Vascular DiseaseDeficiency Anemia
Heart DiseaseAcute Cystitis
Decubitus Ulcer

Graphical network of the top 20 diseases related to Gas Gangrene:



Diseases related to gas gangrene

Symptoms for Gas Gangrene

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Symptoms:

 10
  • large blisters
  • pain in the infected area
  • myonecrosis
  • gas production
  • sepsis

UMLS symptoms related to Gas Gangrene:


torticollis, myoclonus, muscle cramp, chest wall necrosis

Drugs & Therapeutics for Gas Gangrene

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Drugs for Gas Gangrene (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
GlyburideapprovedPhase 1, Phase 210710238-21-83488
Synonyms:
1-((P-(2-(5-chloro-O-Anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexylurea
1-((p-(2-(5-Chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexylurea
1-(P-(2-(5-chloro-2-Methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexylurea
1-(p-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexylurea
10238-21-8
5-Chloro-N-[4-(cyclohexylureidosulfonyl)phenethyl]-2-methoxybenzamide
5-chloro-N-(2-(4-((((Cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-methoxybenzamide
5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide
AB00051949
AC1L1G1Q
AC1Q44V7
AKOS001487495
Abbenclamide
Adiab
Apo-Glibenclamide
Azuglucon
BIDD:GT0239
BPBio1_000344
BRD-K36927236-001-06-0
BRN 2230085
BSPBio_000312
BSPBio_001351
BSPBio_003053
Bastiverit
Benclamin
Betanase
Betanese 5
Bio-0156
Bio1_000076
Bio1_000565
Bio1_001054
Bio2_000071
Bio2_000551
C07022
C23H28ClN3O5S
CAS-10238-21-8
CBiol_001790
CHEBI:5441
CHEMBL472
CID3488
CPD000058229
Calabren
Cytagon
D00336
D005905
DB01016
Daonil
Debtan
Dia-basan
Diabeta
Diabeta (TN)
Diabiphage
Dibelet
DivK1c_000481
Duraglucon
EINECS 233-570-6
EU-0100499
Euclamin
Euglucan
Euglucon
Euglucon 5
Euglucon N
Euglykon
G 0639
G0639_SIAL
G0639_SIGMA
G2539_SIAL
GBN 5
Gen-Glybe
Gewaglucon
Gilemal
Glamide
Glibadone
Gliban
Gliben
Gliben-Puren N
Glibenbeta
Glibenclamid AL
Glibenclamid Basics
Glibenclamid Fabra
Glibenclamid Genericon
Glibenclamid Heumann
Glibenclamid Riker M
Glibenclamid Riker M.
Glibenclamid-Cophar
Glibenclamid-Ratiopharm
Glibenclamida
Glibenclamida [INN-Spanish]
Glibenclamide
Glibenclamide (JP15/INN)
Glibenclamidum
Glibenclamidum [INN-Latin]
Glibenil
Glibens
Glibesyn
Glibet
Glibetic
Glibil
Gliboral
Glicem
Glidiabet
Glimel
Glimide
Glimidstata
Glisulin
Glitisol
Glubate
Gluben
Gluco-Tablimen
Glucobene
Glucohexal
Glucolon
Glucomid
Glucoremed
Glucoven
Glyben
Glybenclamide
Glybenzcyclamide
Glyburide
Glyburide (USP)
Glyburide (micronized)
Glyburide [USAN]
 
Glycolande
Glycomin
Glynase
Glynase (TN)
HB 419
HB 420
HB-419
HB-420
HB419
HB420
HMS1361D13
HMS1568P14
HMS1791D13
HMS1922L08
HMS1989D13
HMS2089L06
HMS2093P04
HMS501I03
Hemi-Daonil
Hexaglucon
Humedia
I06-0716
IDI1_000481
IDI1_033821
KBio1_000481
KBio2_000071
KBio2_000730
KBio2_002639
KBio2_003298
KBio2_005207
KBio2_005866
KBio3_000141
KBio3_000142
KBio3_002273
KBioGR_000071
KBioGR_001897
KBioSS_000071
KBioSS_000730
LS-159295
Lederglib
Libanil
Lisaglucon
Lopac-G-0639
Lopac0_000499
MLS000069721
MLS001077262
Malix
Maninil
Med-Glionil
Melix
Micronase
Micronase (TN)
Micronized glyburide
Miglucan
MolPort-000-784-850
N-(4-(2-(5-Chloro-2-methoxybenzamido)ethyl)phenylsulfonyl)-N'-cyclohexylurea
N-p-[2-(5-Chloro-2-methoxybenzamido)-ethyl]benzene-sulfonyl-N -cyclohexylurea
N-p-[2-(5-Chloro-2-methoxybenzamido)ethyl]benzenesulfonyl-N'-cyclohexylurea
NCGC00015467-01
NCGC00015467-02
NCGC00015467-06
NCGC00015467-16
NCGC00016689-01
NCGC00023447-02
NCGC00023447-04
NCGC00023447-05
NCGC00023447-06
NCGC00023447-07
NCGC00023447-08
NCGC00023447-09
NCGC00023447-10
NCGC00023447-11
NCGC00023447-12
NINDS_000481
Nadib
Neogluconin
Norglicem 5
Normoglucon
Novo-Glyburide
Oprea1_764617
Orabetic
Pira
Praeciglucon
PresTab
Prestwick0_000316
Prestwick1_000316
Prestwick2_000316
Prestwick3_000316
Prestwick_569
Probes1_000431
Probes2_000378
Prodiabet
Renabetic
S1716_Selleck
SAM002564212
SMR000058229
SPBio_001831
SPBio_002531
SPECTRUM2300229
SR-01000000196-5
STK362992
Semi-Daonil
Semi-Euglucon
Semi-Gliben-Puren N
Semi-daonil
Spectrum2_001816
Spectrum3_001327
Spectrum4_001199
Spectrum5_001631
Spectrum_000250
Sugril
Suraben
Tiabet
Tocris-0911
U 26452
U-26452
UNII-SX6K58TVWC
UPCMLD-DP006
UPCMLD-DP006:001
UR 606
Yuglucon
ZINC00537805
glibenclamide
glyburide
2
ImidaclopridPhase 1, Phase 2139105827-78-986418
Synonyms:
(e)-imidacloprid
(z)-imidacloprid
1-((6-Chloro-3-pyridyl)methyl)-N-nitro-2-imidazolidinimine
1-(2-Chloro-5-pyridylmethyl)-2-(nitroimino)imidazolidine
1-[(6-Chloro-3-pyridinyl)methyl]-4,5-dihydro-N-nitro-1H-imidazol-2-amine, 9CI
Admire
Advantage
Advantage flea adulticide
Bayer brand of imidacloprid
 
Confidor
Confidor 200 SL
Confidor SL
Gaucho
Imidacloprid (old RN)
Imidacloprid [iso]
Merit
Merit (insecticide)
Premise 75
Provado
3Hypoglycemic AgentsPhase 1, Phase 24503
4Immunologic FactorsPhase 218483
5Rho(D) Immune GlobulinPhase 2206
6Immunoglobulins, IntravenousPhase 2211
7Immunoglobulin GPhase 2146
8ImmunoglobulinsPhase 24477
9AntibodiesPhase 24477
10
Carbon monoxidePhase 1102281
Synonyms:
 
CO
Carbon monoxide

Interventional clinical trials:

idNameStatusNCT IDPhase
1Glyburide Advantage in Malignant Edema and Stroke PilotCompletedNCT01268683Phase 1, Phase 2
2Glyburide Advantage in Malignant Edema and Stroke - Remedy PharmaceuticalsActive, not recruitingNCT01794182Phase 2
3Immunoglobulin for Necrotizing Soft Tissue Infections: a Randomised Controlled TrialActive, not recruitingNCT02111161Phase 2
4A Clinical Trial of the Clinical Effects of Hyperbaric Oxygen Therapy in Thai Autistic ChildrenCompletedNCT00670891Phase 1
5Biomarkers in Patients With Flesh-eating Bacterial InfectionsCompletedNCT02180906
6Modulation of Biomarkers in Patients With Flesh-eating Bacterial Infections After With Hyperbaric Oxygen TreatmentRecruitingNCT02501382
7Hyperbaric Oxygen Therapy RegistryEnrolling by invitationNCT02483650

Search NIH Clinical Center for Gas Gangrene

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Gas Gangrene cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Gas Gangrene:
Peripheral blood-derived hematopoietic stem cells for leg gangrene
Embryonic/Adult Cultured Cells Related to Gas Gangrene:
Peripheral blood-derived hematopoietic stem cells


Cochrane evidence based reviews: gas gangrene

Genetic Tests for Gas Gangrene

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Anatomical Context for Gas Gangrene

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MalaCards organs/tissues related to Gas Gangrene:

33
Liver, Heart, Lung, Colon, Brain, Breast, Skin

FMA organs/tissues related to Gas Gangrene:

16
Muscle tissue

Animal Models for Gas Gangrene or affiliated genes

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MGI Mouse Phenotypes related to Gas Gangrene:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053857.1CASQ2, DMD, HSPG2, ITGA2B, MB, TNNI3
2MP:00053697.0CASQ1, CASQ2, CPE, DMD, HSPG2, MB
3MP:00053786.9CASQ1, CASQ2, CPE, DMD, HSPG2, MB
4MP:00053766.8CASQ2, CPE, DMD, HSPG2, ITGA2B, MB

Publications for Gas Gangrene

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Articles related to Gas Gangrene:

(show top 50)    (show all 526)
idTitleAuthorsYear
1
Clinical Features of Non-clostridial Gas Gangrene and Risk Factors for In-hospital Mortality. (26369267)
2015
2
Development of Clostridium septicum gas gangrene as an adverse effect of clindamycin-induced Clostridium difficile infection in a pediatric patient. (24590337)
2014
3
Gas gangrene in the abdominal wall: a physician's nightmare. (23684577)
2013
4
Causes of gas gangrene seen at the University of Nigeria Teaching Hospital, Enugu, Nigeria. (18453489)
2008
5
Mortality and diabetes mellitus in amputations of the lower limbs for gas gangrene: a case report. (18829608)
2008
6
Spontaneous, nontraumatic gas gangrene due to Clostridium perfringens. (16310394)
2006
7
Fulminant and fatal gas gangrene of the stomach in a healthy live liver donor. (15376309)
2004
8
Gas gangrene secondary to Clostridium perfringens in pediatric oncology patients. (15232247)
2004
9
Gas gangrene pyaemia with myocardial abscess formation--fatal outcome from a rare infection nowadays. (12909385)
2003
10
Gas gangrene following intramuscular injection of vitamin B-complex: report of a fatal case. (17657062)
2002
11
Non-clostridial gas gangrene caused by Klebsiella pneumoniae: a case report. (11525362)
2001
12
Metastatic gas gangrene of the leg due to acute emphysematous cholecystitis. (11713957)
2001
13
Small intestine perforation because of capacitive coupling as a cause of abdominal wall gas gangrene and clostridial sepsis after laparoscopic cholecystectomy. (11147921)
2000
14
Gas gangrene following intramuscular injection. (10862335)
1999
15
Structure of the key toxin in gas gangrene. (9699639)
1998
16
Role of hyperbaric oxygen therapy in the rapid control of gas gangrene infection and its toxaemia. (2097348)
1990
17
Aortitis due to metastatic gas gangrene. (2618068)
1989
18
Gas-gangrene following arthroscopic surgery. (2706057)
1989
19
Gas gangrene: certain diagnosis or certain death. (2598680)
1989
20
Penicillin allergy, gas gangrene and casualty treatment regime. (3193397)
1988
21
Adenocarcinoma of the colon presenting as lower extremity gas gangrene (metastatic myonecrosis). Case report. (3564828)
1986
22
Fatal nonclostridial gas gangrene in a diabetic: a case report and review of the literature. (3798149)
1986
23
Crepitation simulating gas gangrene. A case report. (3980513)
1985
24
Crepitation simulating gas gangrene. A case report. (4077916)
1985
25
Gas gangrene complicating open forearm fractures. Report of five cases. (833168)
1977
26
Hyperbaric oxygen therapy in anaerobic infections: gas gangrene. (1273078)
1976
27
Anesthetic considerations in patients with gas gangrene. (943986)
1976
28
Proceedings: Post-operative gas gangrene managed by hyperbaric oxygen. (1141310)
1975
29
Interconversion of bacterial agents causing botulism and gas gangrene. (165441)
1975
30
Gas gangrene-on the basis of 19 observations. Advantages of combining surgery with hyperbaric oxygen therapy. (4372493)
1974
31
Gas gangrene. (4353508)
1973
32
Gas gangrene of the extremities. (4683702)
1973
33
Clostridial (gas gangrene) infection in a general hospital. (4715764)
1973
34
Gas gangrene of the anterior abdominal wall. (4352173)
1973
35
The prevention of experimental Clostridium novyi and Cl. perfringens gas gangrene in high-velocity missile wounds by active immunisation. (4345766)
1972
36
Gas gangrene with tetanus. (5057281)
1972
37
Liability for gas gangrene. (5068301)
1972
38
The role of alpha-toxin of Clostridium perfringens in experimental gas gangrene in guinea pigs. (4345498)
1972
39
Gas gangrene panophthalmitis treated with hyperbaric oxygen. (5550538)
1971
40
Gas gangrene treated by hyperbaric oxygen. (5780645)
1969
41
Gas gangrene salpingo-oophoritis. (4295301)
1968
42
Activity of metronidazole against experimental tetanus and gas gangrene. (4302783)
1968
43
Perirectal gas gangrene. (5264647)
1967
44
A CASE OF GAS GANGRENE SUCCESSFULLY TREATED BY HYPERBARIC OXYGENATION. (14253542)
1965
45
VACCINATION OF MONKEYS AGAINST GAS GANGRENE CAUSED BY C1. PERFRINGENS UNDER CONDITIONS OF CHRONIC IRRADIATION. (14079336)
1963
46
ASSAY OF POTENCY OF THE PROPOSED FIFTH INTERNATIONAL STANDARD FOR GAS-GANGRENE ANTITOXIN (PERFRINGENS). (14107746)
1963
47
Gas gangrene following an intramuscular injection of concentrated liver extract. Report of case with fatal termination by fulminating Clostridium perfringens bacillus septicemia. (13872977)
1962
48
Significance of Clostridium welchii infections and their relationship to gas gangrene. (13785713)
1960
49
Experimental gas gangrene: effect of clostridial and staphylococcal toxoids on survival time. (13740508)
1960
50
Anasarca and leukemoid reaction complicating gas gangrene. (18909944)
1948

Variations for Gas Gangrene

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Expression for genes affiliated with Gas Gangrene

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Search GEO for disease gene expression data for Gas Gangrene.

Pathways for genes affiliated with Gas Gangrene

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GO Terms for genes affiliated with Gas Gangrene

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Biological processes related to Gas Gangrene according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1regulation of heart rateGO:00020279.8CASQ2, DMD
2regulation of skeletal muscle contraction by regulation of release of sequestered calcium ionGO:00148099.8CASQ1, DMD
3striated muscle contractionGO:00069419.7CASQ2, TNNI3
4regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionGO:00108819.5CASQ2, DMD
5cardiac muscle contractionGO:00600488.7CASQ2, DMD, TNNI3, TNNT2

Sources for Gas Gangrene

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet