MCID: GSG001
MIFTS: 49

Gas Gangrene malady

Categories: Infectious diseases, Skin diseases

Aliases & Classifications for Gas Gangrene

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Aliases & Descriptions for Gas Gangrene:

Name: Gas Gangrene 35 11 50 39 13 68
Myonecrosis 11 68
 
Gas Bacillus Infection 11

Classifications:



External Ids:

Disease Ontology11 DOID:9159
ICD1030 A48.0
ICD9CM32 040.0
MeSH39 D005738

Summaries for Gas Gangrene

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Disease Ontology:11 A commensal bacterial infectious disease that results in infection, located in muscle tissue, has material basis in Clostridium perfringens, which produce gas that becomes trapped in the infected tissue. Gas gangrene usually develops after injuries or surgery. The infection has symptom large blisters, has symptom pain in the infected area, has symptom myonecrosis, has symptom gas production, and has symptom sepsis.

MalaCards based summary: Gas Gangrene, also known as myonecrosis, is related to anthrax disease and isolated brachycephaly, and has symptoms including muscle cramp, myoclonus and torticollis. An important gene associated with Gas Gangrene is HSPG2 (Heparan Sulfate Proteoglycan 2), and among its related pathways are Muscular Dystrophies and Dystrophin-Glycoprotein Complex and Dilated cardiomyopathy. Affiliated tissues include muscle tissue, liver and colon, and related mouse phenotypes are Negative genetic interaction between BLM-/- and BLM+/+ and cardiovascular system.

Wikipedia:71 Gas gangrene (also known as clostridial myonecrosis and myonecrosis) is a bacterial infection that... more...

Related Diseases for Gas Gangrene

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Diseases related to Gas Gangrene via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 86)
idRelated DiseaseScoreTop Affiliating Genes
1anthrax disease11.1
2isolated brachycephaly10.2TNNI3, TNNT2
3paresthesia10.2DMD, HSPG2
4dermatofibrosarcoma protuberans10.2DMD, HSPG2
5mosaic trisomy 110.2TNNI3, TNNT2
6cardiomyopathy, familial restrictive, 310.1DMD, TNNT2
7myositis fibrosa10.1TNNI3, TNNT2
8retinitis pigmentosa 1810.1TNNI3, TNNT2
9pervasive developmental disorder10.1DMD, TNNI3, TNNT2
10panophthalmitis10.1
11primary cutaneous gamma/delta-positive t-cell lymphoma10.1DMD, TNNI3, TNNT2
12hepatitis10.0
13fasciitis10.0
14necrotizing fasciitis10.0
15orbital margin, hypoplasia of10.0MB, TNNI3
16prosthetic joint infection10.0DMD, MB
17burns9.9
18tetanus9.9
19adenocarcinoma9.9
20inflammatory bowel disease 149.9DMD, MYOM1
21mixed type rhabdomyosarcoma9.9MB, MYOD1
22lupus erythematosus9.9MB, TNNI3, TNNT2
23verruciform xanthoma of skin9.9MB, MYOD1
24intrahepatic bile duct cystadenoma9.9MB, MYOD1
25transitional cell carcinoma9.9MB, MYOD1
26ovarian cystadenoma9.9MB, MYOD1
27adult t-cell leukemia9.9MB, TNNI3, TNNT2
28bile duct rhabdomyosarcoma9.9MB, MYOD1
29cholecystitis9.9
30microscopic breast papilloma9.9DMD, MB, TNNI3
31brain stem infarction9.9MB, MYOD1
32endodermal sinus tumor9.9MB, MYOD1
33leukemia9.8
34peritonitis9.8
35hyperandrogenism9.8MB, TNNI3
36childhood medulloblastoma9.8MB, MYOD1
37cerebral angioma9.8DMD, MB, MYOD1
38immunodeficiency 34, mycobacteriosis, x-linked9.8DMD, MB, TNNI3, TNNT2
39liver cirrhosis9.7
40neutropenia9.7
41lymphoma9.7
42penicillin allergy9.7
43thrombosis9.7
44osteomyelitis9.7
45esophagitis9.7
46pancreatitis9.7
47myocarditis9.7
48emphysematous cholecystitis9.7
49emery-dreifuss muscular dystrophy, dominant type9.7DMD, MB, TNNI3, TNNT2
50lung cancer9.6

Comorbidity relations with Gas Gangrene via Phenotypic Disease Network (PDN):


Peripheral Vascular DiseaseDeficiency Anemia
Heart DiseaseAcute Cystitis
Decubitus Ulcer

Graphical network of the top 20 diseases related to Gas Gangrene:



Diseases related to gas gangrene

Symptoms & Phenotypes for Gas Gangrene

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Symptoms:

 11 (show all 5)
  • large blisters
  • pain in the infected area
  • myonecrosis
  • gas production
  • sepsis

UMLS symptoms related to Gas Gangrene:


muscle cramp, myoclonus, torticollis

GenomeRNAi Phenotypes related to Gas Gangrene according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00255-A-19.7HSPG2, MYOD1, TNNI3, TNNT2

MGI Mouse Phenotypes related to Gas Gangrene according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053857.8DMD, HSPG2, MB, MYOD1, NEU1, PRF1
2MP:00053887.7DMD, HSPG2, MB, MYOD1, NEU1, TNNI3
3MP:00053697.7CPE, DMD, HSPG2, MB, MYOD1, NEU1
4MP:00053787.6CPE, DMD, HSPG2, MB, MYOD1, NEU1

Drugs & Therapeutics for Gas Gangrene

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Drugs for Gas Gangrene (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
GlyburideapprovedPhase 2, Phase 111410238-21-83488
Synonyms:
1-((p-(2-(5-Chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexylurea
1-((p-(2-(5-chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexylurea
1-(p-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexylurea
1-(p-(2-(5-chloro-2-methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexylurea
10238-21-8
5-Chloro-N-[4-(cyclohexylureidosulfonyl)phenethyl]-2-methoxybenzamide
5-chloro-N-(2-(4-((((cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-methoxybenzamide
5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide
AB00051949
AC1L1G1Q
AC1Q44V7
AKOS001487495
Abbenclamide
Adiab
Apo-Glibenclamide
Azuglucon
BIDD:GT0239
BPBio1_000344
BRD-K36927236-001-06-0
BRN 2230085
BSPBio_000312
BSPBio_001351
BSPBio_003053
Bastiverit
Benclamin
Betanase
Betanese 5
Bio-0156
Bio1_000076
Bio1_000565
Bio1_001054
Bio2_000071
Bio2_000551
C07022
C23H28ClN3O5S
CAS-10238-21-8
CBiol_001790
CHEBI:5441
CHEMBL472
CID3488
CPD000058229
Calabren
Cytagon
D00336
D005905
DB01016
Daonil
Debtan
Dia-basan
Diabeta
Diabeta (TN)
Diabiphage
Dibelet
DivK1c_000481
Duraglucon
EINECS 233-570-6
EU-0100499
Euclamin
Euglucan
Euglucon
Euglucon 5
Euglucon N
Euglykon
G 0639
G0639_SIAL
G0639_SIGMA
G2539_SIAL
GBN 5
Gen-Glybe
Gewaglucon
Gilemal
Glamide
Glibadone
Gliban
Gliben
Gliben-Puren N
Glibenbeta
Glibenclamid AL
Glibenclamid Basics
Glibenclamid Fabra
Glibenclamid Genericon
Glibenclamid Heumann
Glibenclamid Riker M
Glibenclamid Riker M.
Glibenclamid-Cophar
Glibenclamid-Ratiopharm
Glibenclamida
Glibenclamida [INN-Spanish]
Glibenclamide
Glibenclamide (JP15/INN)
Glibenclamidum
Glibenclamidum [INN-Latin]
Glibenil
Glibens
Glibesyn
Glibet
Glibetic
Glibil
Gliboral
Glicem
Glidiabet
Glimel
Glimide
Glimidstata
Glisulin
Glitisol
Glubate
Gluben
Gluco-Tablimen
Glucobene
Glucohexal
Glucolon
Glucomid
Glucoremed
Glucoven
Glyben
Glybenclamide
Glybenzcyclamide
Glyburide
Glyburide (USP)
Glyburide (micronized)
Glyburide [USAN]
 
Glycolande
Glycomin
Glynase
Glynase (TN)
HB 419
HB 420
HB-419
HB-420
HB419
HB420
HMS1361D13
HMS1568P14
HMS1791D13
HMS1922L08
HMS1989D13
HMS2089L06
HMS2093P04
HMS501I03
Hemi-Daonil
Hexaglucon
Humedia
I06-0716
IDI1_000481
IDI1_033821
KBio1_000481
KBio2_000071
KBio2_000730
KBio2_002639
KBio2_003298
KBio2_005207
KBio2_005866
KBio3_000141
KBio3_000142
KBio3_002273
KBioGR_000071
KBioGR_001897
KBioSS_000071
KBioSS_000730
LS-159295
Lederglib
Libanil
Lisaglucon
Lopac-G-0639
Lopac0_000499
MLS000069721
MLS001077262
Malix
Maninil
Med-Glionil
Melix
Micronase
Micronase (TN)
Micronized glyburide
Miglucan
MolPort-000-784-850
N-(4-(2-(5-Chloro-2-methoxybenzamido)ethyl)phenylsulfonyl)-N'-cyclohexylurea
N-p-[2-(5-Chloro-2-methoxybenzamido)-ethyl]benzene-sulfonyl-N -cyclohexylurea
N-p-[2-(5-Chloro-2-methoxybenzamido)ethyl]benzenesulfonyl-N'-cyclohexylurea
NCGC00015467-01
NCGC00015467-02
NCGC00015467-06
NCGC00015467-16
NCGC00016689-01
NCGC00023447-02
NCGC00023447-04
NCGC00023447-05
NCGC00023447-06
NCGC00023447-07
NCGC00023447-08
NCGC00023447-09
NCGC00023447-10
NCGC00023447-11
NCGC00023447-12
NINDS_000481
Nadib
Neogluconin
Norglicem 5
Normoglucon
Novo-Glyburide
Oprea1_764617
Orabetic
Pira
Praeciglucon
PresTab
Prestwick0_000316
Prestwick1_000316
Prestwick2_000316
Prestwick3_000316
Prestwick_569
Probes1_000431
Probes2_000378
Prodiabet
Renabetic
S1716_Selleck
SAM002564212
SMR000058229
SPBio_001831
SPBio_002531
SPECTRUM2300229
SR-01000000196-5
STK362992
Semi-Daonil
Semi-Euglucon
Semi-Gliben-Puren N
Semi-daonil
Spectrum2_001816
Spectrum3_001327
Spectrum4_001199
Spectrum5_001631
Spectrum_000250
Sugril
Suraben
Tiabet
Tocris-0911
U 26452
U-26452
UNII-SX6K58TVWC
UPCMLD-DP006
UPCMLD-DP006:001
UR 606
Yuglucon
ZINC00537805
glibenclamide
glyburide
2
ImidaclopridPhase 2, Phase 1187105827-78-986418
Synonyms:
(e)-imidacloprid
(z)-imidacloprid
1-((6-Chloro-3-pyridyl)methyl)-N-nitro-2-imidazolidinimine
1-(2-Chloro-5-pyridylmethyl)-2-(nitroimino)imidazolidine
1-[(6-Chloro-3-pyridinyl)methyl]-4,5-dihydro-N-nitro-1H-imidazol-2-amine, 9CI
Admire
Advantage
Advantage flea adulticide
Bayer brand of imidacloprid
 
Confidor
Confidor 200 SL
Confidor SL
Gaucho
Imidacloprid (old RN)
Imidacloprid [iso]
Merit
Merit (insecticide)
Premise 75
Provado
3Hypoglycemic AgentsPhase 2, Phase 15896
4Immunoglobulins, IntravenousPhase 2333
5Rho(D) Immune GlobulinPhase 2326
6ImmunoglobulinsPhase 26394
7Immunoglobulin GPhase 2275
8gamma-GlobulinsPhase 2326
9AntibodiesPhase 26394
10
Carbon monoxideapprovedPhase 1124630-08-0281
Synonyms:
CO
 
Carbon monoxide
Carboneum oxygenisatum
carbon(II) oxide
11Protein C118

Interventional clinical trials:

idNameStatusNCT IDPhase
1Glyburide Advantage in Malignant Edema and Stroke - Remedy PharmaceuticalsUnknown statusNCT01794182Phase 2
2Glyburide Advantage in Malignant Edema and Stroke PilotCompletedNCT01268683Phase 1, Phase 2
3Immunoglobulin for Necrotizing Soft Tissue Infections: a Randomised Controlled TrialCompletedNCT02111161Phase 2
4A Clinical Trial of the Clinical Effects of Hyperbaric Oxygen Therapy in Thai Autistic ChildrenCompletedNCT00670891Phase 1
5Biomarkers in Patients With Flesh-eating Bacterial InfectionsCompletedNCT02180906
6Modulation of Biomarkers in Patients With Flesh-eating Bacterial Infections After With Hyperbaric Oxygen TreatmentRecruitingNCT02501382
7Prognosis and Treatment of Necrotizing Soft Tissue Infections: A Prospective Cohort StudyRecruitingNCT03147352
8Hyperbaric Oxygen Therapy RegistryEnrolling by invitationNCT02483650

Search NIH Clinical Center for Gas Gangrene

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Gas Gangrene cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Gas Gangrene:
Peripheral blood-derived hematopoietic stem cells for leg gangrene
Embryonic/Adult Cultured Cells Related to Gas Gangrene:
Peripheral blood-derived hematopoietic stem cells


Cochrane evidence based reviews: gas gangrene

Genetic Tests for Gas Gangrene

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Anatomical Context for Gas Gangrene

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MalaCards organs/tissues related to Gas Gangrene:

36
Liver, Colon, Skin, Uterus, Pancreas, Heart, Bone

FMA organs/tissues related to Gas Gangrene:

17
Muscle tissue

Publications for Gas Gangrene

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Articles related to Gas Gangrene:

(show top 50)    (show all 534)
idTitleAuthorsYear
1
CLOSTRIDIAL PARAPROCTITIS WITH GAS GANGRENE OF FRONT-LATERAL ABDOMINAL WALLS AND NECROTIC FASCIO-MYOSITIS (CASE REPORT). (27770534)
2016
2
Uterine Perforation with Intra-Abdominal Clostridium perfringens Gas Gangrene: A Rare and Fatal Infection. (27274183)
2016
3
A case of acute onset postoperative gas gangrene caused by Clostridium perfringens. (27488346)
2016
4
Iatrogenic non-clostridial gas gangrene - a case report. (26672772)
2016
5
An Uncommon Cause of Gas Gangrene. (27713042)
2016
6
Massive gas gangrene secondary to occult colon carcinoma. (27257452)
2016
7
Clostridial Gas Gangrene of the Abdominal Wall After Laparoscopic Cholecystectomy: A Case Report and Review. (27490157)
2016
8
Radiological diagnosis of gas gangrene in a fetus at term. (27590386)
2016
9
Blackish haematuria and gas gangrene. (27272762)
2016
10
Gas Gangrene of the Diabetic Foot. (27159595)
2015
11
A case of nontraumatic gas gangrene in a common marmoset (Callithrix jacchus). (26156080)
2015
12
Clinical Features of Non-clostridial Gas Gangrene and Risk Factors for In-hospital Mortality. (26369267)
2015
13
Necrotizing myonecrosis secondary to hematogenous spread of gas gangrene following colonic perforation. (25787163)
2015
14
Interventions for treating gas gangrene. (26631369)
2015
15
Vertebral osteomyelitis and epidural abscess caused by gas gangrene presenting with complete paraplegia: a case report. (25888739)
2015
16
Clostridium Sacroiliitis (Gas Gangrene) Following Sacroiliac Joint Injection--Case Report and Review of the Literature. (26218953)
2015
17
Hepatic gas gangrene. (25986279)
2015
18
Clostridium septicum Gas Gangrene in Colon Cancer: Importance of Early Diagnosis. (26793397)
2015
19
Retroperitoneal necrotizing fasciitis with gas gangrene, caused by perforated caecal diverticulitis. (25675887)
2015
20
Novel application of vacuum sealing drainage with continuous irrigation of potassium permanganate for managing infective wounds of gas gangrene. (26223928)
2015
21
Retraction: Aeromonas species infection with severe clinical manifestation in Okinawa, Japan-association with gas gangrene. (26790486)
2015
22
A case of freeze-dried gas gangrene antitoxin for the treatment of Clostridium perfringens sepsis. (25748160)
2015
23
Improved vacuum sealing drainage in the treatment of gas gangrene: a case report. (26770624)
2015
24
Fatal retroperitoneal gas gangrene complicating colonoscopic polypectomy without bowel perforation in a healthy adult. (24676832)
2014
25
Images in clinical medicine: Gas gangrene of a prosthetic hip. (25390742)
2014
26
Escherichia coli gas gangrene in an immunosuppressed diabetic man. (24842101)
2014
27
Gas gangrene in the diabetic foot: lessons learned from a salvaged limb. (24720142)
2014
28
Fatal spontaneous Clostridium septicum gas gangrene: a possible association with iatrogenic gastric acid suppression. (24878026)
2014
29
Analysis of genetic similarities between Clostridium perfringens isolates isolated from patients with gas gangrene and from hospital environment conducted with the use of the PFGE method. (24791817)
2014
30
Gas gangrene presenting with back pain. (24811103)
2014
31
Opioid analgesics stop the development of clostridial gas gangrene. (24550443)
2014
32
A Fatal Spontaneous Gas Gangrene due to Clostridium perfringens during Neutropenia of Allogeneic Stem Cell Transplantation: Case Report and Literature Review. (25298910)
2014
33
Fatal massive infectious gas gangrene in a liver transplant recipient. (24415557)
2014
34
Gas gangrene: need for aggressive management in delayed presentation. (24787142)
2014
35
Development of Clostridium septicum gas gangrene as an adverse effect of clindamycin-induced Clostridium difficile infection in a pediatric patient. (24590337)
2014
36
Diagnosis of Gas Gangrene: Does a Discrepancy Exist between the Published Data and Practice. (24345706)
2013
37
Gas Gangrene Caused By Clostridium Perfringens Involving the Liver, Spleen, and Heart in a Man 20 Years After an Orthotopic Liver Transplant: A Case Report. (23962047)
2013
38
Foudroyant Course of an Extensive Clostridium septicum Gas Gangrene in a Diabetic Patient with Occult Carcinoma of the Colon. (23864974)
2013
39
Sublingual gas gangrene after dental therapy. (24149284)
2013
40
Sponge-like appearance of the liver parenchyma due to fatal intrauterine gas gangrene following mechanical abortion. (22772802)
2013
41
Clostridium septicum gas gangrene in the orbit: a case report. (23203898)
2013
42
Comprehensive treatment for gas gangrene of the limbs in earthquakes. (24157141)
2013
43
Gas gangrene in the abdominal wall: a physician's nightmare. (23684577)
2013
44
Clostridial abdominal gas gangrene masquerading as a bowel perforation in an advanced-stage ovarian cancer patient. (23494868)
2013
45
Clostridium perfringens gas gangrene at a wrist intravenous line insertion. (24108766)
2013
46
Foreign Body with Gas Gangrene in an Elderly Patient with Diabetes. (25009760)
2013
47
Clostridium septicum gas gangrene in a previously healthy 8-year-old female with survival. (23583163)
2013
48
Gas gangrene in orthopaedic patients. (24288638)
2013
49
Co-infection with Toxoplasma gondii and Clostridium perfringens in a postpartum woman with uterine gas gangrene: a case report. (22487420)
2012
50
Gas gangrene of the abdominal wall due to late-onset enteric fistula after polyester mesh repair of an incisional hernia. (20922446)
2012

Variations for Gas Gangrene

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Expression for genes affiliated with Gas Gangrene

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Search GEO for disease gene expression data for Gas Gangrene.

Pathways for genes affiliated with Gas Gangrene

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GO Terms for genes affiliated with Gas Gangrene

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Cellular components related to Gas Gangrene according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cardiac myofibrilGO:009751210.4TNNI3, TNNT2
2cardiac Troponin complexGO:199058410.4TNNI3, TNNT2
3troponin complexGO:00058619.8TNNI3, TNNT2
4sarcomereGO:00300179.5MYOM1, TNNI3, TNNT2
5myofibrilGO:00300169.2DMD, MYOD1, TNNI3, TNNT2

Biological processes related to Gas Gangrene according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of ATPase activityGO:003278010.4TNNI3, TNNT2
2regulation of muscle contractionGO:000693710.4TNNI3, TNNT2
3striated muscle contractionGO:000694110.0MYOM1, TNNI3
4cardiac muscle contractionGO:00600489.9DMD, TNNI3, TNNT2
5myotube cell developmentGO:00149049.9DMD, MYOD1
6muscle filament slidingGO:00300499.9DMD, TNNI3, TNNT2
7skeletal muscle tissue developmentGO:00075199.9DMD, MYOD1
8ventricular cardiac muscle tissue morphogenesisGO:00550109.8TNNI3, TNNT2

Molecular functions related to Gas Gangrene according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1troponin C bindingGO:00301729.8TNNI3, TNNT2
2structural constituent of muscleGO:00083079.5DMD, MYOM1

Sources for Gas Gangrene

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet