MCID: GSG001
MIFTS: 66

Gas Gangrene malady

Infectious diseases category

Summaries for Gas Gangrene

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Gangrene is the death of tissues in your body. it happens when a part of your body loses its blood supply. gangrene can happen on the surface of the body, such as on the skin, or inside the body, in muscles or organs. causes include serious injuries problems with blood circulation, such as atherosclerosis and peripheral arterial disease diabetes skin symptoms may include a blue or black color, pain, numbness, and sores that produce a foul-smelling discharge. if the gangrene is internal, you may run a fever and feel unwell, and the area may be swollen and painful. gangrene is a serious condition. it needs immediate attention. treatment includes surgery, antibiotics, and oxygen therapy. in severe cases an amputation may be necessary.

MalaCards: Gas Gangrene, also known as gangrene, is related to adenocarcinoma and leukemia, and has symptoms including pain in the infected area, myonecrosis and gas production. An important gene associated with Gas Gangrene is HSPG2 (heparan sulfate proteoglycan 2), and among its related pathways are Muscular Dystrophies and Dystrophin-Glycoprotein Complex and Non-integrin membrane-ECM interactions. The drugs nitrofurazone and oxygen and the compounds guanidino and phosphatidyl ethanol have been mentioned in the context of this disorder. Affiliated tissues include muscle tissue, skin and liver, and related mouse phenotypes are cardiovascular system and muscle.

Disease Ontology:8 A commensal bacterial infectious disease that results in infection, located in muscle tissue, has material basis in clostridium perfringens, which produce gas that becomes trapped in the infected tissue. gas gangrene usually develops after injuries or surgery. the infection has symptom large blisters, has symptom pain in the infected area, has symptom myonecrosis, has symptom gas production, and has symptom sepsis.

Wikipedia:63 Gas gangrene (also known as \"Clostridial myonecrosis\", and \"Myonecrosis\") is a bacterial infection... more...

Aliases & Classifications for Gas Gangrene

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 33MedlinePlus, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
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Related Diseases for Gas Gangrene

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Gas Gangrene via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 265)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.6PLA2G2A, HSPG2
2leukemia30.4PLA2G2A, ITGA2B, DMD
3diabetes mellitus30.4PIK3C2A, ITGA2B, NEU1, INS
4myocarditis30.3TNNT2, TNNI3, DMD, CHKB
5antiphospholipid syndrome30.2HSPG2
6ischemia30.1HSPG2, TNNT2, DMD, PIK3C2A, CHKB, PLA2G2A
7acute pancreatitis30.1PLA2G1B, PLA2G2A
8acute myocardial infarction30.1CHKB, ITGA2B, PIK3C2A, TNNI3, TNNT2
9myocardial infarction30.0CHKB, ITGA2B, PIK3C2A, TNNI3, TNNT2
10vascular disease30.0TNNT2, TNNI3, PIK3C2A
11pneumonia30.0HSPG2, PIK3C2A, NEU1, PLA2G1B
12atherosclerosis30.0HSPG2, ITGA2B, INS, PLA2G2A, PLA2G1B
13primary hyperoxaluria30.0INS, PIK3C2A, TNNI3, TNNT2
14hypertrophic cardiomyopathy29.8TNNI3, TNNT2
15neuropathy29.8INS, PIK3C2A, DMD
16myopathy29.8CASQ2, CASQ1, TNNT2, TNNI3, DMD, PIK3C2A
17muscular dystrophy29.8CHKB, PIK3C2A, DMD
18duchenne muscular dystrophy29.8TNNT2, TNNI3, DMD, PIK3C2A, CHKB
19myositis29.6DMD, PIK3C2A, CHKB
20panophthalmitis10.5
21burns10.4
22necrotizing fasciitis10.4
23fasciitis10.4
24hepatitis10.4
25tetanus10.4
26cholecystitis10.4
27noma10.3
28meckel's diverticulum10.3
29purpura10.3
30peritonitis10.3
31calciphylaxis10.3
32appendicitis10.2
33malaria10.2
34fournier gangrene10.2
35emphysematous cholecystitis10.2
36cecum adenocarcinoma10.2
37colon adenocarcinoma10.2
38colon cancer10.2
39esophagitis10.2
40liver cirrhosis10.2
41pancreatitis10.2
42plasmodium malariae malaria10.2
43acalculous cholecystitis10.2
44disseminated intravascular coagulation10.2
45mastitis10.2
46abdominal wall defect10.2
47cryoglobulinemia10.1
48polyarteritis nodosa10.1
49plasmodium falciparum malaria10.1
50vasculitis10.1

Graphical network of the top 20 diseases related to Gas Gangrene:



Diseases related to gas gangrene

Clinical Features for Gas Gangrene

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Sources:
8Disease Ontology
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Symptoms:

8
  • pain in the infected area
  • myonecrosis
  • gas production
  • sepsis
  • large blisters

Drugs & Therapeutics for Gas Gangrene

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Gas Gangrene

Drug clinical trials:

Search ClinicalTrials for Gas Gangrene

Search NIH Clinical Center for Gas Gangrene

Search CenterWatch for Gas Gangrene

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Gas Gangrene cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Gas Gangrene:
Peripheral blood-derived hematopoietic stem cells for leg gangrene
Embryonic/Adult Cultured Cells Related to Gas Gangrene:
Peripheral blood-derived hematopoietic stem cells

Genetic Tests for Gas Gangrene

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Anatomical Context for Gas Gangrene

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Gas Gangrene:

32
Skin, Liver, Colon, Uterus, Heart, Brain, Pancreas, Bone, Eye, Small intestine, Breast, Monocytes, Lung, Skeletal muscle, Appendix, Spleen, Bone marrow

FMA organs/tissues related to Gas Gangrene:

14
Muscle tissue

Animal Models for Gas Gangrene or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Gas Gangrene:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053857.9HSPG2, CASQ2, TNNT2, TNNI3, DMD, ITGA2B
2MP:00053697.6INS, HSPG2, CASQ2, CASQ1, TNNT2, TNNI3
3MP:00053767.0HSPG2, CASQ2, TNNT2, DMD, PIK3C2A, ITGA2B
4MP:00053786.9CASQ1, TNNT2, DMD, PIK3C2A, RBM12, NEU1

Publications for Gas Gangrene

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Sources:
50PubMed
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Articles related to Gas Gangrene:

(show top 50)    (show all 502)
idTitleAuthorsYear
1
Sugar inhibits the production of the toxins that trigger clostridial gas gangrene. (22079896)
2012
2
A case of gas gangrene in an immunosuppressed Crohn's patient. (21987630)
2011
3
Fulminant endogenous gas gangrene: role of ultrasonography in the emergency setting. (20579573)
2010
4
Gas gangrene of the liver after a choledocho-jejunostomy. (18628626)
2008
5
Gas gangrene spreading to the bone marrow. (16929090)
2006
6
Spontaneous Clostridium septicum septic arthritis of the shoulder and gas gangrene. a case report. (15805220)
2005
7
Clostridium septicum bacteremia without gas gangrene as a late consequence of a contaminated wound. (15684803)
2004
8
Veno-atrial bypass for the operative treatment of septic gas gangrene secondary to delayed hepatic artery thrombosis. (12780569)
2003
9
Stress proteins of Clostridium perfringens type A immunoreact with antiserum from rabbits infected with gas gangrene. (12910385)
2003
10
Role of Clostridium perfringens phospholipase C in the pathogenesis of gas gangrene. (15019495)
2003
11
Pleural gas gangrene secondary to esophageal injury by an ingested fish bone. (11993201)
2002
12
Diagnosis and management of clostridium perfringens sepsis and uterine gas gangrene. (11773832)
2002
13
Small intestine perforation because of capacitive coupling as a cause of abdominal wall gas gangrene and clostridial sepsis after laparoscopic cholecystectomy. (11147921)
2000
14
Non-traumatic gas gangrene in the abdomen: report of six autopsy cases. (10832675)
2000
15
Clostridial gas gangrene. II. Phospholipase C-induced activation of platelet gpIIbIIIa mediates vascular occlusion and myonecrosis in Clostridium perfringens gas gangrene. (10950775)
2000
16
Gas gangrene in a patient with severe haemophilia A. (10583535)
1999
17
Gas gangrene following intramuscular injection of vitamin B-complex. (9805861)
1998
18
Gas gangrene secondary to subcutaneous insulin injection. (8630171)
1996
19
Gas gangrene: an unusual cause of graft failure in an orthotopic pediatric liver transplant. (1491933)
1992
20
Gas gangrene and congenital agranulocytosis. (2195460)
1990
21
Gas gangrene: certain diagnosis or certain death. (2598680)
1989
22
Penicillin allergy, gas gangrene and casualty treatment regime. (3193397)
1988
23
Clostridial gas gangrene: a review of 48 consecutive cases. (2907224)
1988
24
Early diagnosis of clostridial gas gangrene using sialidase antibodies. (2898309)
1988
25
Gas gangrene. (3135024)
1988
26
Hyperbaric oxygen therapy for gas gangrene casualties in the Lebanon War, 1982. (6735705)
1984
27
Gas gangrene of the omental bursa following acute pancreatitis. (6740250)
1984
28
Nonclostridial gas gangrene: late infection after hip pinning. (6337410)
1983
29
Radiology case of the month no. 33: gas gangrene. (697596)
1978
30
Gas gangrene and related infection: classification, clinical features and aetiology, management and mortality. A report of 88 cases. (196711)
1977
31
Anesthetic considerations in patients with gas gangrene. (943986)
1976
32
Letter: The management of gas gangrene. (1128413)
1975
33
Clostridial (gas gangrene) infection in a general hospital. (4715764)
1973
34
Hyperbaric oxygen in the management of clostridial myonecrosis (gas gangrene). (4749823)
1973
35
Gas gangrene. (4715768)
1973
36
The prevention of experimental Clostridium novyi and Cl. perfringens gas gangrene in high-velocity missile wounds by active immunisation. (4345766)
1972
37
Gas gangrene and hyperbaric oxygen. (5077903)
1972
38
Gas gangrene and hyperbaric oxygen. (4637524)
1972
39
Gas gangrene cholecystitis. (5798209)
1969
40
Gas gangrene in abdominal surgery. (4296734)
1968
41
Effects of chelates in chemotherapy of experimental gas-gangrene toxemia. (4972912)
1968
42
Experimental gas gangrene with food-poisoning Clostridium perfringens type A. (4298928)
1968
43
Gas gangrene following an adrenaline-in-oil injection into the left thigh with survival. (4290503)
1967
44
Gas gangrene of the high-velocity missile wound. (6016749)
1967
45
Hyperbaric oxygen used in the treatment of gas gangrene. (6081093)
1967
46
On the anaerobic streptococcus isolated from a case of gas gangrene. (5297254)
1966
47
CLOSTRIDIAL GAS GANGRENE AND SEPTICEMIA IN MALIGNANT DISEASE. (14308223)
1965
48
The diagnosis and treatment of gas gangrene. (13973838)
1963
49
Experimental gas gangrene: the effect of antiserum on the growth of Clostridium welchii type A. (13874612)
1962
50
Gas gangrene: recent cases. (13742166)
1961

Genetic Variations for Gas Gangrene

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Expression for genes affiliated with Gas Gangrene

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gas Gangrene

Search GEO for disease gene expression data for Gas Gangrene.

Pathways for genes affiliated with Gas Gangrene

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Sources:
51QIAGEN, 53Reactome, 29KEGG, 37NCBI BioSystems Database
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Compounds for genes affiliated with Gas Gangrene

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 2BitterDB, 59Tocris Bioscience, 49PharmGKB, 24HMDB
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Compounds related to Gas Gangrene according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1guanidino4410.2NEU1, CHKB
2phosphatidyl ethanol44 1111.2HSPG2, PLA2G2A
3alpha-hydroxybutyrate4410.1PIK3C2A, CHKB
4N-Tridecanoic Acid1110.0PLA2G2A, PLA2G1B
5thallium4410.0PIK3C2A, CHKB
6scalaradial4410.0PLA2G1B, PLA2G2A
7bw755c4410.0PLA2G1B, PLA2G2A
8dantrolene44 28 1111.9CHKB, PIK3C2A, HSPG2
9beta-hydroxybutyrate449.9INS, CHKB
10manoalide449.9HSPG2, PLA2G1B, PLA2G2A
11p-bromophenacyl bromide449.9PLA2G2A, PLA2G1B, HSPG2
121-oleoyl-2-acetyl-sn-glycerol449.9HSPG2, PLA2G1B, PLA2G2A
13aacocf3449.9PLA2G2A, HSPG2, PLA2G1B
14aristolochic acid44 210.9PLA2G1B, PLA2G2A, HSPG2
15ptca449.9PIK3C2A, CHKB, TNNT2
16quinacrine44 1110.8PLA2G1B, HSPG2, PLA2G2A
17melittin449.8PLA2G1B, PLA2G2A
18ndga449.8PLA2G1B, PLA2G2A, HSPG2
19edelfosine44 5910.8HSPG2, PLA2G1B, PLA2G2A
20gemfibrozil44 28 1111.8PIK3C2A, CHKB, INS
21bezafibrate44 28 1111.7PIK3C2A, CHKB, INS
22succinylcholine44 28 1111.7PIK3C2A, CHKB
23glibenclamide44 28 49 5912.7HSPG2, PLA2G1B, INS
24choline44 11 2411.6CHKB, PIK3C2A, HSPG2, PLA2G2A
25uric acid44 2410.6CHKB, PIK3C2A, INS
26myristic acid44 11 2411.5INS, PLA2G2A, PLA2G1B
27palmitate449.5PLA2G2A, HSPG2, INS
28phosphatidylcholine449.5HSPG2, NEU1, PLA2G2A, PLA2G1B
29ascorbic acid44 2410.5PLA2G2A, PIK3C2A, CHKB, HSPG2
30gamma-hydroxybutyrate449.4PIK3C2A, CHKB
31epinephrine44 11 2411.4PIK3C2A, CHKB, INS, PLA2G2A
32phospholipid449.3PLA2G2A, DMD, PLA2G1B, HSPG2, CHKB
33ly294002449.2HSPG2, PIK3C2A, INS, PLA2G2A
34melphalan44 1110.2CHKB, PIK3C2A, IL4I1
35acetylcholine44 49 28 11 2413.2HSPG2, PIK3C2A, DMD, PLA2G2A, NEU1
36glycogen44 2410.1DMD, TNNT2, CHKB, INS, PIK3C2A
37potassium44 11 2411.0DMD, TNNI3, CHKB, PIK3C2A, PLA2G1B
38dexamethasone44 49 28 1111.9HSPG2, PLA2G1B, PLA2G2A, CHKB, INS
39fatty acid448.7CHKB, PLA2G1B, PLA2G2A, INS, TNNT2, PIK3C2A
40fibrinogen448.7INS, CHKB, ITGA2B, IL4I1, PIK3C2A
41thromboxane a244 249.5IL4I1, PLA2G2A, PLA2G1B, HSPG2, PIK3C2A
42h2o2448.5HSPG2, CHKB, IL4I1, PLA2G2A, PLA2G1B, NEU1
43glycerol44 11 2410.4DMD, NEU1, CHKB, INS, PLA2G2A, PLA2G1B
44arginine448.3PIK3C2A, CHKB, INS, PLA2G2A, DMD, IL4I1
45heparin44 28 11 2411.2PIK3C2A, DMD, TNNT2, HSPG2, PLA2G1B, NEU1
46serine448.1HSPG2, IL4I1, NEU1, DMD, INS, ITGA2B
47alanine447.8INS, PLA2G2A, HSPG2, TNNT2, DMD, PIK3C2A
48creatinine447.8PLA2G2A, TNNI3, IL4I1, INS, CHKB, PIK3C2A
49lactate447.7TNNT2, TNNI3, PIK3C2A, CHKB, INS, IL4I1
50calcium44 49 11 2410.1PLA2G1B, PLA2G2A, CHKB, PIK3C2A, DMD, TNNI3

GO Terms for genes affiliated with Gas Gangrene

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16Gene Ontology
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Cellular components related to Gas Gangrene according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1troponin complexGO:00586110.0TNNI3, TNNT2

Biological processes related to Gas Gangrene according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of ATPase activityGO:03278010.1TNNI3, TNNT2
2regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumGO:0108809.9DMD, CASQ2
3muscle filament slidingGO:0300499.9DMD, TNNI3, TNNT2
4cardiac muscle contractionGO:0600489.8DMD, TNNI3, CASQ2
5regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionGO:0108819.8CASQ2, DMD
6phosphatidylinositol acyl-chain remodelingGO:0361499.7PLA2G2A, PLA2G1B
7regulation of skeletal muscle contraction by regulation of release of sequestered calcium ionGO:0148099.7CASQ1, DMD
8phosphatidylethanolamine acyl-chain remodelingGO:0361529.7PLA2G1B, PLA2G2A
9glycerophospholipid biosynthetic processGO:0464749.6CHKB, PLA2G2A, PLA2G1B
10phosphatidylglycerol acyl-chain remodelingGO:0361489.6PLA2G1B, PLA2G2A
11phosphatidylserine acyl-chain remodelingGO:0361509.4PLA2G1B, PLA2G2A
12phospholipid metabolic processGO:0066449.1PLA2G1B, PLA2G2A, CHKB, PIK3C2A
13small molecule metabolic processGO:0442818.3HSPG2, PIK3C2A, NEU1, CHKB, INS, PLA2G2A

Molecular functions related to Gas Gangrene according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1troponin C bindingGO:03017210.0TNNI3, TNNT2
2phospholipase A2 activityGO:0046239.7PLA2G1B, PLA2G2A
3calcium-dependent phospholipase A2 activityGO:0474989.6PLA2G1B, PLA2G2A
4calcium ion bindingGO:0055098.1CASQ2, CASQ1, DMD, PLA2G2A, PLA2G1B

Products for genes affiliated with Gas Gangrene

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gas Gangrene

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet