MCID: GSG001
MIFTS: 58

Gas Gangrene malady

Infectious diseases, Muscle diseases categories

Aliases & Classifications for Gas Gangrene

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Gas Gangrene, Aliases & Descriptions:

Name: Gas Gangrene 30 9 11 43 60
Gangrene 9 43 32 60
Gas Bacillus Infection 9
Clostridium Infections 60
 
Clostridium Infection 9
Muscle Necrosis 60
Myonecrosis 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Muscle diseases


External Ids:

Disease Ontology9 DOID:9159
ICD9CM27 040.0
MeSH33 D005738
ICD1025 R02, A48.0

Summaries for Gas Gangrene

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MedlinePlus:32 Gangrene is the death of tissues in your body. it happens when a part of your body loses its blood supply. gangrene can happen on the surface of the body, such as on the skin, or inside the body, in muscles or organs. causes include serious injuries problems with blood circulation, such as atherosclerosis and peripheral arterial disease diabetes skin symptoms may include a blue or black color, pain, numbness, and sores that produce a foul-smelling discharge. if the gangrene is internal, you may run a fever and feel unwell, and the area may be swollen and painful. gangrene is a serious condition. it needs immediate attention. treatment includes surgery, antibiotics, and oxygen therapy. in severe cases an amputation may be necessary.

MalaCards based summary: Gas Gangrene, also known as gangrene, is related to myocarditis and myositis, and has symptoms including large blisters, pain in the infected area and myonecrosis. An important gene associated with Gas Gangrene is HSPG2 (heparan sulfate proteoglycan 2), and among its related pathways are Muscular Dystrophies and Dystrophin-Glycoprotein Complex and Glycerophospholipid biosynthesis. The drugs pentoxifylline and oxygen and the compounds phosphatidyl ethanol and scalaradial have been mentioned in the context of this disorder. Affiliated tissues include muscle tissue, skin and liver, and related mouse phenotypes are muscle and homeostasis/metabolism.

Disease Ontology:9 A commensal bacterial infectious disease that results in infection, located in muscle tissue, has material basis in clostridium perfringens, which produce gas that becomes trapped in the infected tissue. gas gangrene usually develops after injuries or surgery. the infection has symptom large blisters, has symptom pain in the infected area, has symptom myonecrosis, has symptom gas production, and has symptom sepsis.

Wikipedia:63 Gas gangrene (also known as clostridial myonecrosis and myonecrosis) is a bacterial infection that... more...

Related Diseases for Gas Gangrene

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Diseases related to Gas Gangrene via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 288)
idRelated DiseaseScoreTop Affiliating Genes
1myocarditis30.5DMD, TNNT2, CHKB
2myositis30.2DMD, PIK3C2A, CHKB
3acute myocardial infarction30.0PIK3C2A, TNNT2, CHKB
4pneumonia30.0PLA2G1B, HSPG2, PIK3C2A
5pancreatitis29.9INS, HSPG2, PLA2G1B, PLA2G2A
6primary hyperoxaluria29.9TNNT2, INS, PIK3C2A
7neuropathy29.7INS, PIK3C2A, DMD
8dermatomyositis29.6DMD, PIK3C2A, HSPG2, CHKB
9atherosclerosis29.6INS, HSPG2, PLA2G1B, PLA2G2A
10ischemia29.1DMD, PIK3C2A, TNNT2, HSPG2, CHKB, PLA2G1B
11myopathy29.0DMD, PIK3C2A, INS, TNNT2, CHKB, CASQ1
12fournier gangrene10.8
13panophthalmitis10.6
14necrotizing fasciitis10.5
15fasciitis10.5
16burns10.5
17hepatitis10.5
18adenocarcinoma10.5
19tetanus10.5
20cholecystitis10.4
21meckel's diverticulum10.4
22noma10.4
23purpura10.3
24leukemia10.3
25peritonitis10.3
26status asthmaticus10.3PIK3C2A
27calciphylaxis10.3
28malaria10.3
29appendicitis10.3
30meningococcemia10.3
31liver cirrhosis10.3
32neutropenia10.3
33emphysematous cholecystitis10.3
34esophagitis10.3
35osteomyelitis10.3
36vasculitis10.2
37creatine phosphokinase, elevated serum10.2CHKB, PIK3C2A
38spinocerebellar ataxia10.2TNNT2, CHKB
39polyarteritis nodosa10.2
40mastitis10.2
41abdominal wall defect10.2
42ectopic pregnancy10.2CHKB, PIK3C2A
43intermediate coronary syndrome10.2TNNT2, PIK3C2A
44thromboangiitis obliterans10.2
45antiphospholipid syndrome10.2
46acalculous cholecystitis10.2
47priapism10.2
48disseminated intravascular coagulation10.2
49membranous glomerulonephritis, antenatal10.2HSPG2, PLA2G2A
50neuroleptic malignant syndrome10.2PIK3C2A, CHKB

Graphical network of the top 20 diseases related to Gas Gangrene:



Diseases related to gas gangrene

Symptoms for Gas Gangrene

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Symptoms:

 9
  • large blisters
  • pain in the infected area
  • myonecrosis
  • gas production
  • sepsis

Drugs & Therapeutics for Gas Gangrene

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Drug clinical trials:

Search ClinicalTrials for Gas Gangrene

Search NIH Clinical Center for Gas Gangrene

Inferred drug relations via UMLS60/NDF-RT39:

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Gas Gangrene cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Gas Gangrene:
Peripheral blood-derived hematopoietic stem cells for leg gangrene
Embryonic/Adult Cultured Cells Related to Gas Gangrene:
Peripheral blood-derived hematopoietic stem cells

Genetic Tests for Gas Gangrene

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Anatomical Context for Gas Gangrene

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MalaCards organs/tissues related to Gas Gangrene:

31
Skin, Liver, Colon, Uterus, Bone, Brain, Heart, Pancreas, Eye, Small intestine, Breast, Bone marrow, Spleen, Skeletal muscle, Lung, Monocytes, Appendix, Neutrophil

FMA organs/tissues related to Gas Gangrene:

14
Muscle tissue

Animal Models for Gas Gangrene or affiliated genes

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MGI Mouse Phenotypes related to Gas Gangrene:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053697.9DMD, INS, TNNT2, HSPG2, CHKB, CASQ1
2MP:00053767.2CASQ2, DMD, PIK3C2A, INS, TNNT2, CHKB
3MP:00053786.5RBM12, CASQ1, PLA2G1B, DMD, HSPG2, TNNT2

Publications for Gas Gangrene

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Articles related to Gas Gangrene:

(show top 50)    (show all 511)
idTitleAuthorsYear
1
Development of Clostridium septicum gas gangrene as an adverse effect of clindamycin-induced Clostridium difficile infection in a pediatric patient. (24590337)
2014
2
Gas gangrene in the abdominal wall: a physician's nightmare. (23684577)
2013
3
Causes of gas gangrene seen at the University of Nigeria Teaching Hospital, Enugu, Nigeria. (18453489)
2008
4
Mortality and diabetes mellitus in amputations of the lower limbs for gas gangrene: a case report. (18829608)
2008
5
Gas gangrene of the liver after a choledocho-jejunostomy. (18628626)
2008
6
Spontaneous, nontraumatic gas gangrene due to Clostridium perfringens. (16310394)
2006
7
Fulminant and fatal gas gangrene of the stomach in a healthy live liver donor. (15376309)
2004
8
Gas gangrene secondary to Clostridium perfringens in pediatric oncology patients. (15232247)
2004
9
Gas gangrene pyaemia with myocardial abscess formation--fatal outcome from a rare infection nowadays. (12909385)
2003
10
Gas gangrene following intramuscular injection of vitamin B-complex: report of a fatal case. (17657062)
2002
11
Non-clostridial gas gangrene caused by Klebsiella pneumoniae: a case report. (11525362)
2001
12
Metastatic gas gangrene of the leg due to acute emphysematous cholecystitis. (11713957)
2001
13
Small intestine perforation because of capacitive coupling as a cause of abdominal wall gas gangrene and clostridial sepsis after laparoscopic cholecystectomy. (11147921)
2000
14
Gas gangrene following intramuscular injection. (10862335)
1999
15
Structure of the key toxin in gas gangrene. (9699639)
1998
16
Aortitis due to metastatic gas gangrene. (2618068)
1989
17
Gas-gangrene following arthroscopic surgery. (2706057)
1989
18
Gas gangrene: certain diagnosis or certain death. (2598680)
1989
19
Penicillin allergy, gas gangrene and casualty treatment regime. (3193397)
1988
20
Adenocarcinoma of the colon presenting as lower extremity gas gangrene (metastatic myonecrosis). Case report. (3564828)
1986
21
Fatal nonclostridial gas gangrene in a diabetic: a case report and review of the literature. (3798149)
1986
22
Crepitation simulating gas gangrene. A case report. (3980513)
1985
23
Crepitation simulating gas gangrene. A case report. (4077916)
1985
24
Gas gangrene complicating open forearm fractures. Report of five cases. (833168)
1977
25
Hyperbaric oxygen therapy in anaerobic infections: gas gangrene. (1273078)
1976
26
Anesthetic considerations in patients with gas gangrene. (943986)
1976
27
Proceedings: Post-operative gas gangrene managed by hyperbaric oxygen. (1141310)
1975
28
Interconversion of bacterial agents causing botulism and gas gangrene. (165441)
1975
29
Gas gangrene-on the basis of 19 observations. Advantages of combining surgery with hyperbaric oxygen therapy. (4372493)
1974
30
Gas gangrene. (4353508)
1973
31
Gas gangrene of the extremities. (4683702)
1973
32
Clostridial (gas gangrene) infection in a general hospital. (4715764)
1973
33
Gas gangrene of the anterior abdominal wall. (4352173)
1973
34
The prevention of experimental Clostridium novyi and Cl. perfringens gas gangrene in high-velocity missile wounds by active immunisation. (4345766)
1972
35
Gas gangrene with tetanus. (5057281)
1972
36
Liability for gas gangrene. (5068301)
1972
37
The role of alpha-toxin of Clostridium perfringens in experimental gas gangrene in guinea pigs. (4345498)
1972
38
Gas gangrene panophthalmitis treated with hyperbaric oxygen. (5550538)
1971
39
Gas gangrene treated by hyperbaric oxygen. (5780645)
1969
40
Gas gangrene salpingo-oophoritis. (4295301)
1968
41
Activity of metronidazole against experimental tetanus and gas gangrene. (4302783)
1968
42
Perirectal gas gangrene. (5264647)
1967
43
A CASE OF GAS GANGRENE SUCCESSFULLY TREATED BY HYPERBARIC OXYGENATION. (14253542)
1965
44
VACCINATION OF MONKEYS AGAINST GAS GANGRENE CAUSED BY C1. PERFRINGENS UNDER CONDITIONS OF CHRONIC IRRADIATION. (14079336)
1963
45
ASSAY OF POTENCY OF THE PROPOSED FIFTH INTERNATIONAL STANDARD FOR GAS-GANGRENE ANTITOXIN (PERFRINGENS). (14107746)
1963
46
Gas gangrene following an intramuscular injection of concentrated liver extract. Report of case with fatal termination by fulminating Clostridium perfringens bacillus septicemia. (13872977)
1962
47
Significance of Clostridium welchii infections and their relationship to gas gangrene. (13785713)
1960
48
Experimental gas gangrene: effect of clostridial and staphylococcal toxoids on survival time. (13740508)
1960
49
Gas gangrene after the injection of adrenaline-in-oil, with a report of three cases. (13767243)
1960
50
Anasarca and leukemoid reaction complicating gas gangrene. (18909944)
1948

Variations for Gas Gangrene

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Expression for genes affiliated with Gas Gangrene

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Search GEO for disease gene expression data for Gas Gangrene.

Pathways for genes affiliated with Gas Gangrene

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Pathways related to Gas Gangrene according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8HSPG2, DMD
2
Show member pathways
8.5PLA2G2A, PLA2G1B, CHKB, PIK3C2A
3
Show member pathways
7.9PIK3C2A, INS, HSPG2, CHKB, PLA2G1B, PLA2G2A

Compounds for genes affiliated with Gas Gangrene

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Compounds related to Gas Gangrene according to GeneCards Suite gene sharing:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1phosphatidyl ethanol43 1211.0PLA2G2A, HSPG2
2scalaradial4310.0PLA2G1B, PLA2G2A
3bw755c4310.0PLA2G1B, PLA2G2A
4manoalide439.8PLA2G2A, PLA2G1B, HSPG2
5p-bromophenacyl bromide439.8PLA2G2A, PLA2G1B, HSPG2
61-oleoyl-2-acetyl-sn-glycerol439.8HSPG2, PLA2G1B, PLA2G2A
7aacocf3439.8PLA2G2A, PLA2G1B, HSPG2
8aristolochic acid43 210.8HSPG2, PLA2G1B, PLA2G2A
9quinacrine43 1210.7HSPG2, PLA2G1B, PLA2G2A
10ndga439.7HSPG2, PLA2G1B, PLA2G2A
11edelfosine43 5910.7PLA2G2A, PLA2G1B, HSPG2
12thallium439.7PIK3C2A, CHKB
13palmitate439.7PLA2G2A, HSPG2, INS
14alpha-hydroxybutyrate439.7PIK3C2A, CHKB
15glibenclamide43 28 49 5912.7PLA2G1B, HSPG2, INS
16melittin439.6PLA2G2A, PLA2G1B
17dantrolene28 43 1211.5CHKB, HSPG2, PIK3C2A
18myristic acid43 24 1211.5PLA2G2A, PLA2G1B, INS
19ptca439.5CHKB, TNNT2, PIK3C2A
20gemfibrozil28 43 1211.4CHKB, INS, PIK3C2A
21bezafibrate43 28 1211.4PIK3C2A, INS, CHKB
22gamma-hydroxybutyrate439.4CHKB, PIK3C2A
23uric acid43 2410.3PIK3C2A, INS, CHKB
24pge2439.3HSPG2, CHKB, PLA2G1B, PLA2G2A
25atorvastatin43 49 28 24 1213.2PIK3C2A, CHKB, PLA2G2A
26choline43 24 1211.2PIK3C2A, HSPG2, CHKB, PLA2G2A
27ascorbic acid43 2410.1PIK3C2A, HSPG2, CHKB, PLA2G2A
28prednisolone43 28 1211.1DMD, PIK3C2A, CHKB
29succinylcholine43 49 28 1212.1CHKB, PIK3C2A
30phospholipid439.1DMD, HSPG2, CHKB, PLA2G1B, PLA2G2A
31dexamethasone43 49 28 1212.0INS, HSPG2, CHKB, PLA2G1B, PLA2G2A
32epinephrine43 24 1211.0PIK3C2A, INS, CHKB, PLA2G2A
33ly294002439.0PLA2G2A, HSPG2, INS, PIK3C2A
34acetylcholine43 49 28 24 1213.0DMD, PIK3C2A, HSPG2, PLA2G2A
35thromboxane a243 249.9PIK3C2A, HSPG2, PLA2G1B, PLA2G2A
36cyclosporin a43 28 5910.9DMD, PIK3C2A, CHKB, PLA2G2A
37urea43 24 1210.9DMD, PIK3C2A, CHKB
38potassium43 24 1210.7PLA2G1B, CHKB, PIK3C2A, DMD
39glutamate438.7PIK3C2A, INS, HSPG2, CHKB, PLA2G2A
40glycogen43 249.7DMD, PIK3C2A, INS, TNNT2, CHKB
41arginine438.6DMD, PIK3C2A, INS, CHKB, PLA2G2A
42superoxide43 249.6PIK3C2A, CHKB, PLA2G1B, PLA2G2A
43atp43 289.4DMD, PIK3C2A, HSPG2, CHKB, PLA2G1B
44creatinine438.4DMD, PIK3C2A, INS, TNNT2, CHKB, PLA2G2A
45fatty acid438.3PIK3C2A, INS, TNNT2, CHKB, PLA2G1B, PLA2G2A
46lactate438.2PIK3C2A, INS, TNNT2, CHKB, PLA2G1B, PLA2G2A
47glycerol43 24 1210.2PLA2G2A, PLA2G1B, CHKB, INS, PIK3C2A, DMD
48alanine438.1DMD, PIK3C2A, INS, TNNT2, HSPG2, CHKB
49heparin43 28 24 1211.0DMD, PIK3C2A, TNNT2, HSPG2, CHKB, PLA2G1B
50calcium43 49 24 1210.1DMD, PIK3C2A, TNNT2, HSPG2, CHKB, PLA2G1B

GO Terms for genes affiliated with Gas Gangrene

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Biological processes related to Gas Gangrene according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumGO:00108809.9CASQ2, DMD
2regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionGO:00108819.8DMD, CASQ2
3regulation of skeletal muscle contraction by regulation of release of sequestered calcium ionGO:00148099.7CASQ1, DMD
4phosphatidylinositol acyl-chain remodelingGO:00361499.7PLA2G1B, PLA2G2A
5phosphatidylethanolamine acyl-chain remodelingGO:00361529.6PLA2G2A, PLA2G1B
6phosphatidylglycerol acyl-chain remodelingGO:00361489.5PLA2G2A, PLA2G1B
7glycerophospholipid biosynthetic processGO:00464749.5CHKB, PLA2G1B, PLA2G2A
8phosphatidylserine acyl-chain remodelingGO:00361509.3PLA2G2A, PLA2G1B
9phospholipid metabolic processGO:00066448.7PLA2G2A, PLA2G1B, CHKB, PIK3C2A
10small molecule metabolic processGO:00442818.0PIK3C2A, INS, HSPG2, CHKB, PLA2G1B, PLA2G2A

Molecular functions related to Gas Gangrene according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1phospholipase A2 activityGO:00046239.6PLA2G2A, PLA2G1B
2calcium-dependent phospholipase A2 activityGO:00474989.3PLA2G2A, PLA2G1B
3calcium ion bindingGO:00055098.3CASQ2, CASQ1, PLA2G2A, PLA2G1B, DMD

Products for genes affiliated with Gas Gangrene

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Sources for Gas Gangrene

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet