MCID: GSG001
MIFTS: 49

Gas Gangrene malady

Categories: Infectious diseases, Skin diseases, Muscle diseases

Aliases & Classifications for Gas Gangrene

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Aliases & Descriptions for Gas Gangrene:

Name: Gas Gangrene 35 11 50 39 13 68
Myonecrosis 11 68
 
Gas Bacillus Infection or Gangrene 11
Gas Bacillus Infection 11

Classifications:



External Ids:

Disease Ontology11 DOID:9159
ICD1030 A48.0
ICD9CM32 040.0
MeSH39 D005738

Summaries for Gas Gangrene

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Disease Ontology:11 A commensal bacterial infectious disease that results in infection, located in muscle tissue, has material basis in Clostridium perfringens, which produce gas that becomes trapped in the infected tissue. Gas gangrene usually develops after injuries or surgery. The infection has symptom large blisters, has symptom pain in the infected area, has symptom myonecrosis, has symptom gas production, and has symptom sepsis.

MalaCards based summary: Gas Gangrene, also known as myonecrosis, is related to anthrax disease and tubular renal disease-cardiomyopathy syndrome, and has symptoms including large blisters, pain in the infected area and myonecrosis. An important gene associated with Gas Gangrene is HSPG2 (Heparan Sulfate Proteoglycan 2), and among its related pathways are Muscular Dystrophies and Dystrophin-Glycoprotein Complex and Cardiac Progenitor Differentiation. Affiliated tissues include muscle tissue, liver and colon, and related mouse phenotypes are Negative genetic interaction between BLM-/- and BLM+/+ and cardiovascular system.

Wikipedia:71 Gas gangrene (also known as clostridial myonecrosis and myonecrosis) is a bacterial infection that... more...

Related Diseases for Gas Gangrene

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Diseases related to Gas Gangrene via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 91)
idRelated DiseaseScoreTop Affiliating Genes
1anthrax disease11.1
2tubular renal disease-cardiomyopathy syndrome10.4TNNI3, TNNT2
3atrial standstill, digenic10.4TNNI3, TNNT2
4transient neonatal thrombocytopenia10.4TNNI3, TNNT2
5neuronal migration disorders10.3DMD, HSPG2
6myopathy, distal, 410.2DMD, MYOM1
7meige syndrome10.2TNNI3, TNNT2
8longitudinal vaginal septum10.1DMD, TNNI3, TNNT2
9autoimmune disease of skin and connective tissue10.1DMD, TNNI3, TNNT2
10ulcerative blepharitis10.1TNNI3, TNNT2
11panophthalmitis10.1
12central cloudy dystrophy of francois10.0MB, TNNI3
13fungal meningitis10.0MB, TNNI3
14proliferating trichilemmal cyst10.0DMD, MB
15hepatitis10.0
16fasciitis10.0
17necrotizing fasciitis10.0
18ectodermal dysplasia10.0DMD, TNNI3, TNNT2
19burns10.0
20tetanus10.0
21adenocarcinoma10.0
22fletcher factor deficiency9.9DMD, MYOD1
23malignant hypertension9.9MB, TNNI3
24cholecystitis9.9
25leukemia9.8
26peritonitis9.8
27testis sarcoma9.8MB, MYOD1
28transitional papilloma9.8MB, MYOD1
29subacute leukemia9.8MB, MYOD1
30prostate rhabdomyosarcoma9.8MB, MYOD1
31pediatric fibrosarcoma9.8MB, MYOD1
32immunodeficiency 34, mycobacteriosis, x-linked9.8DMD, MB, TNNI3
33vaginal yolk sac tumor9.8MB, MYOD1
34liver cirrhosis9.8
35neutropenia9.8
36lymphoma9.8
37penicillin allergy9.8
38osteomyelitis9.8
39esophagitis9.8
40pancreatitis9.8
41myocarditis9.8
42emphysematous cholecystitis9.8
43pulmonary plasma cell granuloma9.7MB, MYOD1
44colon carcinoma in situ9.7MB, TNNI3, TNNT2
45adult respiratory distress syndrome9.7MB, TNNI3, TNNT2
46omphalocele9.7MB, MYOD1
47orbit rhabdomyosarcoma9.7MB, MYOD1
48adult central nervous system primitive neuroectodermal neoplasm9.7MB, MYOD1
49vulvar sebaceous carcinoma9.7MB, MYOD1
50central nervous system rhabdomyosarcoma9.7MB, MYOD1

Comorbidity relations with Gas Gangrene via Phenotypic Disease Network (PDN):


Acute CystitisDecubitus Ulcer
Deficiency AnemiaHeart Disease
Peripheral Vascular Disease

Graphical network of the top 20 diseases related to Gas Gangrene:



Diseases related to gas gangrene

Symptoms & Phenotypes for Gas Gangrene

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Symptoms:

 11 (show all 5)
  • large blisters
  • pain in the infected area
  • myonecrosis
  • gas production
  • sepsis

UMLS symptoms related to Gas Gangrene:


chest wall necrosis, muscle cramp, myoclonus, torticollis

GenomeRNAi Phenotypes related to Gas Gangrene according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00255-A-19.6HSPG2, MYOD1, TNNI3, TNNT2

MGI Mouse Phenotypes related to Gas Gangrene according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.2DMD, HSPG2, MB, MYOD1, NEU1, TNNI3
2MP:00053887.7DMD, HSPG2, MB, MYOD1, NEU1, TNNI3
3MP:00053787.7CPE, DMD, HSPG2, MB, MYOD1, NEU1
4MP:00053767.6CPE, DMD, HSPG2, MB, MYOD1, NEU1
5MP:00053697.6CPE, DMD, HSPG2, MB, MYOD1, NEU1

Drugs & Therapeutics for Gas Gangrene

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Drugs for Gas Gangrene (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
GlyburideapprovedPhase 1, Phase 211110238-21-83488
Synonyms:
1-((P-(2-(5-chloro-O-Anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexylurea
1-((p-(2-(5-Chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexylurea
1-(P-(2-(5-chloro-2-Methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexylurea
1-(p-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexylurea
10238-21-8
5-Chloro-N-[4-(cyclohexylureidosulfonyl)phenethyl]-2-methoxybenzamide
5-chloro-N-(2-(4-((((Cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-methoxybenzamide
5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide
AB00051949
AC1L1G1Q
AC1Q44V7
AKOS001487495
Abbenclamide
Adiab
Apo-Glibenclamide
Azuglucon
BIDD:GT0239
BPBio1_000344
BRD-K36927236-001-06-0
BRN 2230085
BSPBio_000312
BSPBio_001351
BSPBio_003053
Bastiverit
Benclamin
Betanase
Betanese 5
Bio-0156
Bio1_000076
Bio1_000565
Bio1_001054
Bio2_000071
Bio2_000551
C07022
C23H28ClN3O5S
CAS-10238-21-8
CBiol_001790
CHEBI:5441
CHEMBL472
CID3488
CPD000058229
Calabren
Cytagon
D00336
D005905
DB01016
Daonil
Debtan
Dia-basan
Diabeta
Diabeta (TN)
Diabiphage
Dibelet
DivK1c_000481
Duraglucon
EINECS 233-570-6
EU-0100499
Euclamin
Euglucan
Euglucon
Euglucon 5
Euglucon N
Euglykon
G 0639
G0639_SIAL
G0639_SIGMA
G2539_SIAL
GBN 5
Gen-Glybe
Gewaglucon
Gilemal
Glamide
Glibadone
Gliban
Gliben
Gliben-Puren N
Glibenbeta
Glibenclamid AL
Glibenclamid Basics
Glibenclamid Fabra
Glibenclamid Genericon
Glibenclamid Heumann
Glibenclamid Riker M
Glibenclamid Riker M.
Glibenclamid-Cophar
Glibenclamid-Ratiopharm
Glibenclamida
Glibenclamida [INN-Spanish]
Glibenclamide
Glibenclamide (JP15/INN)
Glibenclamidum
Glibenclamidum [INN-Latin]
Glibenil
Glibens
Glibesyn
Glibet
Glibetic
Glibil
Gliboral
Glicem
Glidiabet
Glimel
Glimide
Glimidstata
Glisulin
Glitisol
Glubate
Gluben
Gluco-Tablimen
Glucobene
Glucohexal
Glucolon
Glucomid
Glucoremed
Glucoven
Glyben
Glybenclamide
Glybenzcyclamide
Glyburide
Glyburide (USP)
Glyburide (micronized)
Glyburide [USAN]
 
Glycolande
Glycomin
Glynase
Glynase (TN)
HB 419
HB 420
HB-419
HB-420
HB419
HB420
HMS1361D13
HMS1568P14
HMS1791D13
HMS1922L08
HMS1989D13
HMS2089L06
HMS2093P04
HMS501I03
Hemi-Daonil
Hexaglucon
Humedia
I06-0716
IDI1_000481
IDI1_033821
KBio1_000481
KBio2_000071
KBio2_000730
KBio2_002639
KBio2_003298
KBio2_005207
KBio2_005866
KBio3_000141
KBio3_000142
KBio3_002273
KBioGR_000071
KBioGR_001897
KBioSS_000071
KBioSS_000730
LS-159295
Lederglib
Libanil
Lisaglucon
Lopac-G-0639
Lopac0_000499
MLS000069721
MLS001077262
Malix
Maninil
Med-Glionil
Melix
Micronase
Micronase (TN)
Micronized glyburide
Miglucan
MolPort-000-784-850
N-(4-(2-(5-Chloro-2-methoxybenzamido)ethyl)phenylsulfonyl)-N'-cyclohexylurea
N-p-[2-(5-Chloro-2-methoxybenzamido)-ethyl]benzene-sulfonyl-N -cyclohexylurea
N-p-[2-(5-Chloro-2-methoxybenzamido)ethyl]benzenesulfonyl-N'-cyclohexylurea
NCGC00015467-01
NCGC00015467-02
NCGC00015467-06
NCGC00015467-16
NCGC00016689-01
NCGC00023447-02
NCGC00023447-04
NCGC00023447-05
NCGC00023447-06
NCGC00023447-07
NCGC00023447-08
NCGC00023447-09
NCGC00023447-10
NCGC00023447-11
NCGC00023447-12
NINDS_000481
Nadib
Neogluconin
Norglicem 5
Normoglucon
Novo-Glyburide
Oprea1_764617
Orabetic
Pira
Praeciglucon
PresTab
Prestwick0_000316
Prestwick1_000316
Prestwick2_000316
Prestwick3_000316
Prestwick_569
Probes1_000431
Probes2_000378
Prodiabet
Renabetic
S1716_Selleck
SAM002564212
SMR000058229
SPBio_001831
SPBio_002531
SPECTRUM2300229
SR-01000000196-5
STK362992
Semi-Daonil
Semi-Euglucon
Semi-Gliben-Puren N
Semi-daonil
Spectrum2_001816
Spectrum3_001327
Spectrum4_001199
Spectrum5_001631
Spectrum_000250
Sugril
Suraben
Tiabet
Tocris-0911
U 26452
U-26452
UNII-SX6K58TVWC
UPCMLD-DP006
UPCMLD-DP006:001
UR 606
Yuglucon
ZINC00537805
glibenclamide
glyburide
2ImmunoglobulinsPhase 26045
3Immunoglobulins, IntravenousPhase 2324
4Rho(D) Immune GlobulinPhase 2317
5Immunoglobulin GPhase 2265
6gamma-GlobulinsPhase 2317
7Hypoglycemic AgentsPhase 1, Phase 25733
8
ImidaclopridPhase 1, Phase 2166105827-78-986418
Synonyms:
(e)-imidacloprid
(z)-imidacloprid
1-((6-Chloro-3-pyridyl)methyl)-N-nitro-2-imidazolidinimine
1-(2-Chloro-5-pyridylmethyl)-2-(nitroimino)imidazolidine
1-[(6-Chloro-3-pyridinyl)methyl]-4,5-dihydro-N-nitro-1H-imidazol-2-amine, 9CI
Admire
Advantage
Advantage flea adulticide
Bayer brand of imidacloprid
 
Confidor
Confidor 200 SL
Confidor SL
Gaucho
Imidacloprid (old RN)
Imidacloprid [iso]
Merit
Merit (insecticide)
Premise 75
Provado
9AntibodiesPhase 26045
10
Carbon monoxideapprovedPhase 1116630-08-0281
Synonyms:
CO
 
Carbon monoxide
Carboneum oxygenisatum
carbon(II) oxide

Interventional clinical trials:

idNameStatusNCT IDPhase
1Glyburide Advantage in Malignant Edema and Stroke PilotCompletedNCT01268683Phase 1, Phase 2
2Immunoglobulin for Necrotizing Soft Tissue Infections: a Randomised Controlled TrialCompletedNCT02111161Phase 2
3Glyburide Advantage in Malignant Edema and Stroke - Remedy PharmaceuticalsActive, not recruitingNCT01794182Phase 2
4A Clinical Trial of the Clinical Effects of Hyperbaric Oxygen Therapy in Thai Autistic ChildrenCompletedNCT00670891Phase 1
5Biomarkers in Patients With Flesh-eating Bacterial InfectionsCompletedNCT02180906
6Modulation of Biomarkers in Patients With Flesh-eating Bacterial Infections After With Hyperbaric Oxygen TreatmentRecruitingNCT02501382
7Hyperbaric Oxygen Therapy RegistryEnrolling by invitationNCT02483650

Search NIH Clinical Center for Gas Gangrene

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Gas Gangrene cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Gas Gangrene:
Peripheral blood-derived hematopoietic stem cells for leg gangrene
Embryonic/Adult Cultured Cells Related to Gas Gangrene:
Peripheral blood-derived hematopoietic stem cells


Cochrane evidence based reviews: gas gangrene

Genetic Tests for Gas Gangrene

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Anatomical Context for Gas Gangrene

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MalaCards organs/tissues related to Gas Gangrene:

36
Liver, Colon, Skin, Uterus, Pancreas, Brain, Bone

FMA organs/tissues related to Gas Gangrene:

17
Muscle tissue

Publications for Gas Gangrene

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Articles related to Gas Gangrene:

(show top 50)    (show all 533)
idTitleAuthorsYear
1
Blackish haematuria and gas gangrene. (27272762)
2016
2
Clostridial Gas Gangrene of the Abdominal Wall After Laparoscopic Cholecystectomy: A Case Report and Review. (27490157)
2016
3
An Uncommon Cause of Gas Gangrene. (27713042)
2016
4
Uterine Perforation with Intra-Abdominal Clostridium perfringens Gas Gangrene: A Rare and Fatal Infection. (27274183)
2016
5
Iatrogenic non-clostridial gas gangrene - a case report. (26672772)
2016
6
Radiological diagnosis of gas gangrene in a fetus at term. (27590386)
2016
7
Massive gas gangrene secondary to occult colon carcinoma. (27257452)
2016
8
CLOSTRIDIAL PARAPROCTITIS WITH GAS GANGRENE OF FRONT-LATERAL ABDOMINAL WALLS AND NECROTIC FASCIO-MYOSITIS (CASE REPORT). (27770534)
2016
9
A case of acute onset postoperative gas gangrene caused by Clostridium perfringens. (27488346)
2016
10
Clinical Features of Non-clostridial Gas Gangrene and Risk Factors for In-hospital Mortality. (26369267)
2015
11
Clostridium Sacroiliitis (Gas Gangrene) Following Sacroiliac Joint Injection--Case Report and Review of the Literature. (26218953)
2015
12
Improved vacuum sealing drainage in the treatment of gas gangrene: a case report. (26770624)
2015
13
Retroperitoneal necrotizing fasciitis with gas gangrene, caused by perforated caecal diverticulitis. (25675887)
2015
14
Interventions for treating gas gangrene. (26631369)
2015
15
Gas Gangrene of the Diabetic Foot. (27159595)
2015
16
Vertebral osteomyelitis and epidural abscess caused by gas gangrene presenting with complete paraplegia: a case report. (25888739)
2015
17
Clostridium septicum Gas Gangrene in Colon Cancer: Importance of Early Diagnosis. (26793397)
2015
18
A case of nontraumatic gas gangrene in a common marmoset (Callithrix jacchus). (26156080)
2015
19
Retraction: Aeromonas species infection with severe clinical manifestation in Okinawa, Japan-association with gas gangrene. (26790486)
2015
20
Novel application of vacuum sealing drainage with continuous irrigation of potassium permanganate for managing infective wounds of gas gangrene. (26223928)
2015
21
Necrotizing myonecrosis secondary to hematogenous spread of gas gangrene following colonic perforation. (25787163)
2015
22
Hepatic gas gangrene. (25986279)
2015
23
A case of freeze-dried gas gangrene antitoxin for the treatment of Clostridium perfringens sepsis. (25748160)
2015
24
Development of Clostridium septicum gas gangrene as an adverse effect of clindamycin-induced Clostridium difficile infection in a pediatric patient. (24590337)
2014
25
Analysis of genetic similarities between Clostridium perfringens isolates isolated from patients with gas gangrene and from hospital environment conducted with the use of the PFGE method. (24791817)
2014
26
Escherichia coli gas gangrene in an immunosuppressed diabetic man. (24842101)
2014
27
Fatal spontaneous Clostridium septicum gas gangrene: a possible association with iatrogenic gastric acid suppression. (24878026)
2014
28
Fatal massive infectious gas gangrene in a liver transplant recipient. (24415557)
2014
29
Opioid analgesics stop the development of clostridial gas gangrene. (24550443)
2014
30
Fatal retroperitoneal gas gangrene complicating colonoscopic polypectomy without bowel perforation in a healthy adult. (24676832)
2014
31
Gas gangrene: need for aggressive management in delayed presentation. (24787142)
2014
32
Images in clinical medicine: Gas gangrene of a prosthetic hip. (25390742)
2014
33
Gas gangrene in the diabetic foot: lessons learned from a salvaged limb. (24720142)
2014
34
A Fatal Spontaneous Gas Gangrene due to Clostridium perfringens during Neutropenia of Allogeneic Stem Cell Transplantation: Case Report and Literature Review. (25298910)
2014
35
Gas gangrene presenting with back pain. (24811103)
2014
36
Gas gangrene in the abdominal wall: a physician's nightmare. (23684577)
2013
37
Gas gangrene in orthopaedic patients. (24288638)
2013
38
Gas Gangrene Caused By Clostridium Perfringens Involving the Liver, Spleen, and Heart in a Man 20 Years After an Orthotopic Liver Transplant: A Case Report. (23962047)
2013
39
Clostridium perfringens gas gangrene at a wrist intravenous line insertion. (24108766)
2013
40
Clostridial abdominal gas gangrene masquerading as a bowel perforation in an advanced-stage ovarian cancer patient. (23494868)
2013
41
Sponge-like appearance of the liver parenchyma due to fatal intrauterine gas gangrene following mechanical abortion. (22772802)
2013
42
Clostridium septicum gas gangrene in the orbit: a case report. (23203898)
2013
43
Foudroyant Course of an Extensive Clostridium septicum Gas Gangrene in a Diabetic Patient with Occult Carcinoma of the Colon. (23864974)
2013
44
Diagnosis of Gas Gangrene: Does a Discrepancy Exist between the Published Data and Practice. (24345706)
2013
45
Comprehensive treatment for gas gangrene of the limbs in earthquakes. (24157141)
2013
46
Foreign Body with Gas Gangrene in an Elderly Patient with Diabetes. (25009760)
2013
47
Clostridium septicum gas gangrene in a previously healthy 8-year-old female with survival. (23583163)
2013
48
Sublingual gas gangrene after dental therapy. (24149284)
2013
49
Sugar inhibits the production of the toxins that trigger clostridial gas gangrene. (22079896)
2012
50
The role of x-rays in the treatment of gas gangrene: a historical assessment. (23304109)
2012

Variations for Gas Gangrene

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Expression for genes affiliated with Gas Gangrene

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Search GEO for disease gene expression data for Gas Gangrene.

Pathways for genes affiliated with Gas Gangrene

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GO Terms for genes affiliated with Gas Gangrene

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Cellular components related to Gas Gangrene according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1troponin complexGO:00058619.8TNNI3, TNNT2
2sarcomereGO:00300179.4MYOM1, TNNI3, TNNT2
3myofibrilGO:00300169.3DMD, MYOD1, TNNI3, TNNT2

Biological processes related to Gas Gangrene according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of ATPase activityGO:003278010.2TNNI3, TNNT2
2regulation of muscle contractionGO:000693710.1TNNI3, TNNT2
3myotube cell developmentGO:001490410.0DMD, MYOD1
4cardiac muscle contractionGO:00600489.9DMD, TNNI3, TNNT2
5muscle filament slidingGO:00300499.9DMD, TNNI3, TNNT2
6ventricular cardiac muscle tissue morphogenesisGO:00550109.8TNNI3, TNNT2

Molecular functions related to Gas Gangrene according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1troponin C bindingGO:00301729.8TNNI3, TNNT2
2structural constituent of muscleGO:00083079.6DMD, MYOM1

Sources for Gas Gangrene

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet