MCID: GSG001
MIFTS: 58

Gas Gangrene malady

Infectious diseases, Muscle diseases categories

Aliases & Classifications for Gas Gangrene

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Summaries for Gas Gangrene

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MedlinePlus:32 Gangrene is the death of tissues in your body. it happens when a part of your body loses its blood supply. gangrene can happen on the surface of the body, such as on the skin, or inside the body, in muscles or organs. causes include serious injuries problems with blood circulation, such as atherosclerosis and peripheral arterial disease diabetes skin symptoms may include a blue or black color, pain, numbness, and sores that produce a foul-smelling discharge. if the gangrene is internal, you may run a fever and feel unwell, and the area may be swollen and painful. gangrene is a serious condition. it needs immediate attention. treatment includes surgery, antibiotics, and oxygen therapy. in severe cases an amputation may be necessary.

MalaCards based summary: Gas Gangrene, also known as gangrene, is related to myocarditis and myositis, and has symptoms including large blisters, pain in the infected area and myonecrosis. An important gene associated with Gas Gangrene is HSPG2 (heparan sulfate proteoglycan 2), and among its related pathways are Muscular Dystrophies and Dystrophin-Glycoprotein Complex and Glycerophospholipid biosynthesis. The drugs pentoxifylline and oxygen and the compounds phosphatidyl ethanol and scalaradial have been mentioned in the context of this disorder. Affiliated tissues include muscle tissue, skin and liver, and related mouse phenotypes are muscle and homeostasis/metabolism.

Disease Ontology:8 A commensal bacterial infectious disease that results in infection, located in muscle tissue, has material basis in clostridium perfringens, which produce gas that becomes trapped in the infected tissue. gas gangrene usually develops after injuries or surgery. the infection has symptom large blisters, has symptom pain in the infected area, has symptom myonecrosis, has symptom gas production, and has symptom sepsis.

Wikipedia:64 Gas gangrene (also known as clostridial myonecrosis and myonecrosis) is a bacterial infection that... more...

Related Diseases for Gas Gangrene

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Diseases related to Gas Gangrene via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 288)
idRelated DiseaseScoreTop Affiliating Genes
1myocarditis30.5DMD, TNNT2, CHKB
2myositis30.2DMD, PIK3C2A, CHKB
3acute myocardial infarction30.0PIK3C2A, TNNT2, CHKB
4pneumonia30.0PLA2G1B, HSPG2, PIK3C2A
5pancreatitis29.9INS, HSPG2, PLA2G1B, PLA2G2A
6primary hyperoxaluria29.9TNNT2, INS, PIK3C2A
7neuropathy29.7INS, PIK3C2A, DMD
8dermatomyositis29.6DMD, PIK3C2A, HSPG2, CHKB
9atherosclerosis29.6INS, HSPG2, PLA2G1B, PLA2G2A
10ischemia29.1DMD, PIK3C2A, TNNT2, HSPG2, CHKB, PLA2G1B
11myopathy29.0DMD, PIK3C2A, INS, TNNT2, CHKB, CASQ1
12fournier gangrene10.8
13panophthalmitis10.6
14necrotizing fasciitis10.5
15fasciitis10.5
16burns10.5
17hepatitis10.5
18adenocarcinoma10.5
19tetanus10.5
20cholecystitis10.4
21meckel's diverticulum10.4
22noma10.4
23purpura10.3
24leukemia10.3
25peritonitis10.3
26status asthmaticus10.3PIK3C2A
27calciphylaxis10.3
28malaria10.3
29appendicitis10.3
30meningococcemia10.3
31liver cirrhosis10.3
32neutropenia10.3
33emphysematous cholecystitis10.3
34esophagitis10.3
35osteomyelitis10.3
36vasculitis10.2
37creatine phosphokinase, elevated serum10.2CHKB, PIK3C2A
38spinocerebellar ataxia10.2TNNT2, CHKB
39polyarteritis nodosa10.2
40mastitis10.2
41abdominal wall defect10.2
42ectopic pregnancy10.2CHKB, PIK3C2A
43intermediate coronary syndrome10.2TNNT2, PIK3C2A
44thromboangiitis obliterans10.2
45antiphospholipid syndrome10.2
46acalculous cholecystitis10.2
47priapism10.2
48disseminated intravascular coagulation10.2
49membranous glomerulonephritis, antenatal10.2HSPG2, PLA2G2A
50neuroleptic malignant syndrome10.2PIK3C2A, CHKB

Graphical network of the top 20 diseases related to Gas Gangrene:



Diseases related to gas gangrene

Symptoms for Gas Gangrene

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Symptoms:

 8
  • large blisters
  • pain in the infected area
  • myonecrosis
  • gas production
  • sepsis

Drugs & Therapeutics for Gas Gangrene

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Drug clinical trials:

Search ClinicalTrials for Gas Gangrene

Search NIH Clinical Center for Gas Gangrene

Inferred drug relations via UMLS61/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Gas Gangrene cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Gas Gangrene:
Peripheral blood-derived hematopoietic stem cells for leg gangrene
Embryonic/Adult Cultured Cells Related to Gas Gangrene:
Peripheral blood-derived hematopoietic stem cells

Genetic Tests for Gas Gangrene

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Anatomical Context for Gas Gangrene

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MalaCards organs/tissues related to Gas Gangrene:

31
Skin, Liver, Colon, Uterus, Bone, Brain, Heart, Pancreas, Eye, Small intestine, Breast, Bone marrow, Spleen, Skeletal muscle, Lung, Monocytes, Appendix, Neutrophil

FMA organs/tissues related to Gas Gangrene:

14
Muscle tissue

Animal Models for Gas Gangrene or affiliated genes

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MGI Mouse Phenotypes related to Gas Gangrene:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053697.9CASQ2, DMD, INS, TNNT2, HSPG2, CHKB
2MP:00053767.2PIK3C2A, INS, TNNT2, HSPG2, CHKB, PLA2G1B
3MP:00053786.5DMD, PIK3C2A, INS, TNNT2, HSPG2, PLA2G1B

Publications for Gas Gangrene

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Articles related to Gas Gangrene:

(show top 50)    (show all 511)
idTitleAuthorsYear
1
Development of Clostridium septicum gas gangrene as an adverse effect of clindamycin-induced Clostridium difficile infection in a pediatric patient. (24590337)
2014
2
Gas gangrene in the abdominal wall: a physician's nightmare. (23684577)
2013
3
Causes of gas gangrene seen at the University of Nigeria Teaching Hospital, Enugu, Nigeria. (18453489)
2008
4
Mortality and diabetes mellitus in amputations of the lower limbs for gas gangrene: a case report. (18829608)
2008
5
Gas gangrene of the liver after a choledocho-jejunostomy. (18628626)
2008
6
Spontaneous, nontraumatic gas gangrene due to Clostridium perfringens. (16310394)
2006
7
Fulminant and fatal gas gangrene of the stomach in a healthy live liver donor. (15376309)
2004
8
Gas gangrene secondary to Clostridium perfringens in pediatric oncology patients. (15232247)
2004
9
Gas gangrene pyaemia with myocardial abscess formation--fatal outcome from a rare infection nowadays. (12909385)
2003
10
Gas gangrene following intramuscular injection of vitamin B-complex: report of a fatal case. (17657062)
2002
11
Non-clostridial gas gangrene caused by Klebsiella pneumoniae: a case report. (11525362)
2001
12
Metastatic gas gangrene of the leg due to acute emphysematous cholecystitis. (11713957)
2001
13
Small intestine perforation because of capacitive coupling as a cause of abdominal wall gas gangrene and clostridial sepsis after laparoscopic cholecystectomy. (11147921)
2000
14
Gas gangrene following intramuscular injection. (10862335)
1999
15
Structure of the key toxin in gas gangrene. (9699639)
1998
16
Aortitis due to metastatic gas gangrene. (2618068)
1989
17
Gas-gangrene following arthroscopic surgery. (2706057)
1989
18
Gas gangrene: certain diagnosis or certain death. (2598680)
1989
19
Penicillin allergy, gas gangrene and casualty treatment regime. (3193397)
1988
20
Adenocarcinoma of the colon presenting as lower extremity gas gangrene (metastatic myonecrosis). Case report. (3564828)
1986
21
Fatal nonclostridial gas gangrene in a diabetic: a case report and review of the literature. (3798149)
1986
22
Crepitation simulating gas gangrene. A case report. (3980513)
1985
23
Crepitation simulating gas gangrene. A case report. (4077916)
1985
24
Gas gangrene complicating open forearm fractures. Report of five cases. (833168)
1977
25
Hyperbaric oxygen therapy in anaerobic infections: gas gangrene. (1273078)
1976
26
Anesthetic considerations in patients with gas gangrene. (943986)
1976
27
Proceedings: Post-operative gas gangrene managed by hyperbaric oxygen. (1141310)
1975
28
Interconversion of bacterial agents causing botulism and gas gangrene. (165441)
1975
29
Gas gangrene-on the basis of 19 observations. Advantages of combining surgery with hyperbaric oxygen therapy. (4372493)
1974
30
Gas gangrene. (4353508)
1973
31
Gas gangrene of the extremities. (4683702)
1973
32
Clostridial (gas gangrene) infection in a general hospital. (4715764)
1973
33
Gas gangrene of the anterior abdominal wall. (4352173)
1973
34
The prevention of experimental Clostridium novyi and Cl. perfringens gas gangrene in high-velocity missile wounds by active immunisation. (4345766)
1972
35
Gas gangrene with tetanus. (5057281)
1972
36
Liability for gas gangrene. (5068301)
1972
37
The role of alpha-toxin of Clostridium perfringens in experimental gas gangrene in guinea pigs. (4345498)
1972
38
Gas gangrene panophthalmitis treated with hyperbaric oxygen. (5550538)
1971
39
Gas gangrene treated by hyperbaric oxygen. (5780645)
1969
40
Gas gangrene salpingo-oophoritis. (4295301)
1968
41
Activity of metronidazole against experimental tetanus and gas gangrene. (4302783)
1968
42
Perirectal gas gangrene. (5264647)
1967
43
A CASE OF GAS GANGRENE SUCCESSFULLY TREATED BY HYPERBARIC OXYGENATION. (14253542)
1965
44
VACCINATION OF MONKEYS AGAINST GAS GANGRENE CAUSED BY C1. PERFRINGENS UNDER CONDITIONS OF CHRONIC IRRADIATION. (14079336)
1963
45
ASSAY OF POTENCY OF THE PROPOSED FIFTH INTERNATIONAL STANDARD FOR GAS-GANGRENE ANTITOXIN (PERFRINGENS). (14107746)
1963
46
Gas gangrene following an intramuscular injection of concentrated liver extract. Report of case with fatal termination by fulminating Clostridium perfringens bacillus septicemia. (13872977)
1962
47
Significance of Clostridium welchii infections and their relationship to gas gangrene. (13785713)
1960
48
Experimental gas gangrene: effect of clostridial and staphylococcal toxoids on survival time. (13740508)
1960
49
Gas gangrene after the injection of adrenaline-in-oil, with a report of three cases. (13767243)
1960
50
Anasarca and leukemoid reaction complicating gas gangrene. (18909944)
1948

Variations for Gas Gangrene

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Expression for genes affiliated with Gas Gangrene

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Search GEO for disease gene expression data for Gas Gangrene.

Pathways for genes affiliated with Gas Gangrene

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Pathways related to Gas Gangrene according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8HSPG2, DMD
2
Show member pathways
8.5PLA2G2A, PLA2G1B, CHKB, PIK3C2A
3
Show member pathways
7.9PIK3C2A, INS, HSPG2, CHKB, PLA2G1B, PLA2G2A

Compounds for genes affiliated with Gas Gangrene

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Compounds related to Gas Gangrene according to GeneCards Suite gene sharing:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1phosphatidyl ethanol44 1111.0PLA2G2A, HSPG2
2scalaradial4410.0PLA2G1B, PLA2G2A
3bw755c4410.0PLA2G1B, PLA2G2A
4beta-hydroxybutyrate449.8CHKB, INS
5manoalide449.8HSPG2, PLA2G2A, PLA2G1B
6p-bromophenacyl bromide449.8PLA2G2A, HSPG2, PLA2G1B
71-oleoyl-2-acetyl-sn-glycerol449.8PLA2G1B, HSPG2, PLA2G2A
8aacocf3449.8HSPG2, PLA2G1B, PLA2G2A
9aristolochic acid44 110.8PLA2G2A, PLA2G1B, HSPG2
10quinacrine44 1110.7PLA2G1B, HSPG2, PLA2G2A
11ndga449.7PLA2G1B, PLA2G2A, HSPG2
12thallium449.7CHKB, PIK3C2A
13edelfosine44 6010.7PLA2G2A, PLA2G1B, HSPG2
14palmitate449.7INS, HSPG2, PLA2G2A
15alpha-hydroxybutyrate449.7PIK3C2A, CHKB
16glibenclamide44 28 50 6012.7INS, HSPG2, PLA2G1B
17melittin449.6PLA2G1B, PLA2G2A
18dantrolene28 44 1111.5PIK3C2A, HSPG2, CHKB
19myristic acid44 24 1111.5PLA2G2A, PLA2G1B, INS
20ptca449.5TNNT2, PIK3C2A, CHKB
21gemfibrozil28 44 1111.4INS, PIK3C2A, CHKB
22bezafibrate44 28 1111.4INS, PIK3C2A, CHKB
23uric acid44 2410.3PIK3C2A, INS, CHKB
24pge2449.3PLA2G1B, PLA2G2A, CHKB, HSPG2
25choline44 24 1111.2HSPG2, PIK3C2A, PLA2G2A, CHKB
26atorvastatin44 50 28 24 1113.1PLA2G2A, CHKB, PIK3C2A
27ascorbic acid44 2410.1PLA2G2A, CHKB, PIK3C2A, HSPG2
28prednisolone44 28 1111.1DMD, CHKB, PIK3C2A
29succinylcholine44 50 28 1112.1CHKB, PIK3C2A
30phospholipid449.1PLA2G2A, PLA2G1B, CHKB, HSPG2, DMD
31dexamethasone44 50 28 1112.0PLA2G2A, PLA2G1B, INS, CHKB, HSPG2
32epinephrine44 24 1111.0PLA2G2A, CHKB, INS, PIK3C2A
33ly294002449.0PLA2G2A, HSPG2, INS, PIK3C2A
34acetylcholine44 50 28 24 1113.0DMD, PIK3C2A, HSPG2, PLA2G2A
35thromboxane a244 249.9PIK3C2A, HSPG2, PLA2G1B, PLA2G2A
36cyclosporin a44 28 6010.9CHKB, PIK3C2A, DMD, PLA2G2A
37urea44 24 1110.9PIK3C2A, DMD, CHKB
38potassium44 24 1110.7PIK3C2A, CHKB, DMD, PLA2G1B
39glutamate448.7PIK3C2A, CHKB, HSPG2, INS, PLA2G2A
40glycogen44 249.7TNNT2, CHKB, DMD, INS, PIK3C2A
41arginine448.6PIK3C2A, PLA2G2A, CHKB, DMD, INS
42superoxide44 249.6PIK3C2A, CHKB, PLA2G1B, PLA2G2A
43atp44 289.4CHKB, HSPG2, DMD, PIK3C2A, PLA2G1B
44creatinine448.4PLA2G2A, CHKB, TNNT2, DMD, INS, PIK3C2A
45fatty acid448.3PLA2G2A, INS, TNNT2, CHKB, PLA2G1B, PIK3C2A
46lactate448.2INS, PLA2G2A, CHKB, PLA2G1B, TNNT2, PIK3C2A
47glycerol44 24 1110.2DMD, PIK3C2A, INS, CHKB, PLA2G1B, PLA2G2A
48alanine448.1TNNT2, PLA2G2A, DMD, PIK3C2A, INS, CHKB
49heparin44 28 24 1111.0PLA2G2A, PIK3C2A, TNNT2, DMD, HSPG2, CHKB
50calcium44 50 24 1110.1PLA2G1B, PIK3C2A, DMD, TNNT2, HSPG2, CHKB

GO Terms for genes affiliated with Gas Gangrene

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Biological processes related to Gas Gangrene according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumGO:00108809.9CASQ2, DMD
2regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionGO:00108819.8DMD, CASQ2
3regulation of skeletal muscle contraction by regulation of release of sequestered calcium ionGO:00148099.7CASQ1, DMD
4phosphatidylinositol acyl-chain remodelingGO:00361499.7PLA2G1B, PLA2G2A
5phosphatidylethanolamine acyl-chain remodelingGO:00361529.6PLA2G2A, PLA2G1B
6phosphatidylglycerol acyl-chain remodelingGO:00361489.5PLA2G2A, PLA2G1B
7glycerophospholipid biosynthetic processGO:00464749.5CHKB, PLA2G1B, PLA2G2A
8phosphatidylserine acyl-chain remodelingGO:00361509.3PLA2G2A, PLA2G1B
9phospholipid metabolic processGO:00066448.7PLA2G2A, PLA2G1B, CHKB, PIK3C2A
10small molecule metabolic processGO:00442818.0PIK3C2A, INS, HSPG2, CHKB, PLA2G1B, PLA2G2A

Molecular functions related to Gas Gangrene according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1phospholipase A2 activityGO:00046239.6PLA2G2A, PLA2G1B
2calcium-dependent phospholipase A2 activityGO:00474989.3PLA2G2A, PLA2G1B
3calcium ion bindingGO:00055098.3CASQ2, CASQ1, PLA2G2A, PLA2G1B, DMD

Sources for Gas Gangrene

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet