MCID: GSG001
MIFTS: 49

Gas Gangrene malady

Categories: Infectious diseases, Skin diseases

Aliases & Classifications for Gas Gangrene

Aliases & Descriptions for Gas Gangrene:

Name: Gas Gangrene 38 12 52 42 14 69
Myonecrosis 12 69
Gas Bacillus Infection 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9159
ICD10 33 A48.0
ICD9CM 35 040.0
MeSH 42 D005738
UMLS 69 C0017105

Summaries for Gas Gangrene

Disease Ontology : 12 A commensal bacterial infectious disease that results_in infection, located in muscle tissue, has material basis in Clostridium perfringens, which produce gas that becomes trapped in the infected tissue. Gas gangrene usually develops after injuries or surgery. The infection has symptom large blisters, has symptom pain in the infected area, has symptom myonecrosis, has symptom gas production, and has symptom sepsis.

MalaCards based summary : Gas Gangrene, also known as myonecrosis, is related to anthrax disease and isolated brachycephaly, and has symptoms including large blisters, pain in the infected area and myonecrosis. An important gene associated with Gas Gangrene is HSPG2 (Heparan Sulfate Proteoglycan 2), and among its related pathways/superpathways are Dilated cardiomyopathy and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Glyburide and Imidacloprid have been mentioned in the context of this disorder. Affiliated tissues include liver, colon and skin, and related phenotypes are Negative genetic interaction between BLM-/- and BLM+/+ and cardiovascular system

Wikipedia : 71 Gas gangrene (also known as clostridial myonecrosis and myonecrosis) is a bacterial infection that... more...

Related Diseases for Gas Gangrene

Diseases related to Gas Gangrene via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
id Related Disease Score Top Affiliating Genes
1 anthrax disease 11.1
2 isolated brachycephaly 10.2 TNNI3 TNNT2
3 paresthesia 10.2 DMD HSPG2
4 dermatofibrosarcoma protuberans 10.2 DMD HSPG2
5 mosaic trisomy 1 10.2 TNNI3 TNNT2
6 cardiomyopathy, familial restrictive, 3 10.1 DMD TNNT2
7 myositis fibrosa 10.1 TNNI3 TNNT2
8 retinitis pigmentosa 18 10.1 TNNI3 TNNT2
9 pervasive developmental disorder 10.1 DMD TNNI3 TNNT2
10 panophthalmitis 10.1
11 primary cutaneous gamma/delta-positive t-cell lymphoma 10.1 DMD TNNI3 TNNT2
12 fasciitis 10.0
13 necrotizing fasciitis 10.0
14 hepatitis 10.0
15 orbital margin, hypoplasia of 10.0 MB TNNI3
16 prosthetic joint infection 10.0 DMD MB
17 adenocarcinoma 9.9
18 tetanus 9.9
19 burns 9.9
20 inflammatory bowel disease 14 9.9 DMD MYOM1
21 mixed type rhabdomyosarcoma 9.9 MB MYOD1
22 lupus erythematosus 9.9 MB TNNI3 TNNT2
23 verruciform xanthoma of skin 9.9 MB MYOD1
24 intrahepatic bile duct cystadenoma 9.9 MB MYOD1
25 transitional cell carcinoma 9.9 MB MYOD1
26 ovarian cystadenoma 9.9 MB MYOD1
27 adult t-cell leukemia 9.9 MB TNNI3 TNNT2
28 bile duct rhabdomyosarcoma 9.9 MB MYOD1
29 cholecystitis 9.9
30 microscopic breast papilloma 9.9 DMD MB TNNI3
31 brain stem infarction 9.9 MB MYOD1
32 endodermal sinus tumor 9.9 MB MYOD1
33 peritonitis 9.8
34 leukemia 9.8
35 hyperandrogenism 9.8 MB TNNI3
36 childhood medulloblastoma 9.8 MB MYOD1
37 cerebral angioma 9.8 DMD MB MYOD1
38 immunodeficiency 34, mycobacteriosis, x-linked 9.8 DMD MB TNNI3 TNNT2
39 liver cirrhosis 9.7
40 neutropenia 9.7
41 lymphoma 9.7
42 myocarditis 9.7
43 penicillin allergy 9.7
44 thrombosis 9.7
45 osteomyelitis 9.7
46 pancreatitis 9.7
47 emphysematous cholecystitis 9.7
48 esophagitis 9.7
49 emery-dreifuss muscular dystrophy, dominant type 9.7 DMD MB TNNI3 TNNT2
50 pericarditis 9.6

Comorbidity relations with Gas Gangrene via Phenotypic Disease Network (PDN):


Acute Cystitis Decubitus Ulcer
Deficiency Anemia Heart Disease
Peripheral Vascular Disease

Graphical network of the top 20 diseases related to Gas Gangrene:



Diseases related to Gas Gangrene

Symptoms & Phenotypes for Gas Gangrene

Symptoms:

12
  • large blisters
  • pain in the infected area
  • myonecrosis
  • gas production
  • sepsis

UMLS symptoms related to Gas Gangrene:


muscle cramp, myoclonus, torticollis

GenomeRNAi Phenotypes related to Gas Gangrene according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Negative genetic interaction between BLM-/- and BLM+/+ GR00255-A-1 8.92 HSPG2 MYOD1 TNNI3 TNNT2

MGI Mouse Phenotypes related to Gas Gangrene:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.86 DMD HSPG2 MB MYOD1 NEU1 PRF1
2 growth/size/body region MP:0005378 9.76 CPE DMD HSPG2 MB MYOD1 NEU1
3 muscle MP:0005369 9.56 TNNT2 CPE DMD HSPG2 MB MYOD1
4 respiratory system MP:0005388 9.1 DMD HSPG2 MB MYOD1 NEU1 TNNI3

Drugs & Therapeutics for Gas Gangrene

Drugs for Gas Gangrene (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glyburide Approved Phase 2,Phase 1 10238-21-8 3488
2
Imidacloprid Phase 2,Phase 1 105827-78-9 86418
3 Hypoglycemic Agents Phase 2,Phase 1
4 Immunoglobulin G Phase 2
5 Immunoglobulins Phase 2
6 gamma-Globulins Phase 2
7 Immunoglobulins, Intravenous Phase 2
8 Rho(D) Immune Globulin Phase 2
9 Antibodies Phase 2
10
Carbon monoxide Approved Phase 1 630-08-0 281
11 Protein C

Interventional clinical trials:


id Name Status NCT ID Phase
1 Glyburide Advantage in Malignant Edema and Stroke - Remedy Pharmaceuticals Unknown status NCT01794182 Phase 2
2 Glyburide Advantage in Malignant Edema and Stroke Pilot Completed NCT01268683 Phase 1, Phase 2
3 Immunoglobulin for Necrotizing Soft Tissue Infections: a Randomised Controlled Trial Completed NCT02111161 Phase 2
4 A Clinical Trial of the Clinical Effects of Hyperbaric Oxygen Therapy in Thai Autistic Children Completed NCT00670891 Phase 1
5 Biomarkers in Patients With Flesh-eating Bacterial Infections Completed NCT02180906
6 Modulation of Biomarkers in Patients With Flesh-eating Bacterial Infections After With Hyperbaric Oxygen Treatment Recruiting NCT02501382
7 Prognosis and Treatment of Necrotizing Soft Tissue Infections: A Prospective Cohort Study Recruiting NCT03147352
8 Hyperbaric Oxygen Therapy Registry Enrolling by invitation NCT02483650

Search NIH Clinical Center for Gas Gangrene

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Gas Gangrene cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Gas Gangrene:
Peripheral blood-derived hematopoietic stem cells for leg gangrene
Embryonic/Adult Cultured Cells Related to Gas Gangrene:
Peripheral blood-derived hematopoietic stem cells

Cochrane evidence based reviews: gas gangrene

Genetic Tests for Gas Gangrene

Anatomical Context for Gas Gangrene

MalaCards organs/tissues related to Gas Gangrene:

39
Liver, Colon, Skin, Uterus, Heart, Bone, Pancreas

The Foundational Model of Anatomy Ontology organs/tissues related to Gas Gangrene:

18
Muscle Tissue

Publications for Gas Gangrene

Articles related to Gas Gangrene:

(show top 50) (show all 534)
id Title Authors Year
1
CLOSTRIDIAL PARAPROCTITIS WITH GAS GANGRENE OF FRONT-LATERAL ABDOMINAL WALLS AND NECROTIC FASCIO-MYOSITIS (CASE REPORT). ( 27770534 )
2016
2
Uterine Perforation with Intra-Abdominal Clostridium perfringens Gas Gangrene: A Rare and Fatal Infection. ( 27274183 )
2016
3
A case of acute onset postoperative gas gangrene caused by Clostridium perfringens. ( 27488346 )
2016
4
Iatrogenic non-clostridial gas gangrene - a case report. ( 26672772 )
2016
5
An Uncommon Cause of Gas Gangrene. ( 27713042 )
2016
6
Massive gas gangrene secondary to occult colon carcinoma. ( 27257452 )
2016
7
Clostridial Gas Gangrene of the Abdominal Wall After Laparoscopic Cholecystectomy: A Case Report and Review. ( 27490157 )
2016
8
Radiological diagnosis of gas gangrene in a fetus at term. ( 27590386 )
2016
9
Blackish haematuria and gas gangrene. ( 27272762 )
2016
10
Gas Gangrene of the Diabetic Foot. ( 27159595 )
2015
11
A case of nontraumatic gas gangrene in a common marmoset (Callithrix jacchus). ( 26156080 )
2015
12
Clinical Features of Non-clostridial Gas Gangrene and Risk Factors for In-hospital Mortality. ( 26369267 )
2015
13
Necrotizing myonecrosis secondary to hematogenous spread of gas gangrene following colonic perforation. ( 25787163 )
2015
14
Interventions for treating gas gangrene. ( 26631369 )
2015
15
Vertebral osteomyelitis and epidural abscess caused by gas gangrene presenting with complete paraplegia: a case report. ( 25888739 )
2015
16
Clostridium Sacroiliitis (Gas Gangrene) Following Sacroiliac Joint Injection--Case Report and Review of the Literature. ( 26218953 )
2015
17
Hepatic gas gangrene. ( 25986279 )
2015
18
Clostridium septicum Gas Gangrene in Colon Cancer: Importance of Early Diagnosis. ( 26793397 )
2015
19
Retroperitoneal necrotizing fasciitis with gas gangrene, caused by perforated caecal diverticulitis. ( 25675887 )
2015
20
Novel application of vacuum sealing drainage with continuous irrigation of potassium permanganate for managing infective wounds of gas gangrene. ( 26223928 )
2015
21
Retraction: Aeromonas species infection with severe clinical manifestation in Okinawa, Japan-association with gas gangrene. ( 26790486 )
2015
22
A case of freeze-dried gas gangrene antitoxin for the treatment of Clostridium perfringens sepsis. ( 25748160 )
2015
23
Improved vacuum sealing drainage in the treatment of gas gangrene: a case report. ( 26770624 )
2015
24
Fatal retroperitoneal gas gangrene complicating colonoscopic polypectomy without bowel perforation in a healthy adult. ( 24676832 )
2014
25
Images in clinical medicine: Gas gangrene of a prosthetic hip. ( 25390742 )
2014
26
Escherichia coli gas gangrene in an immunosuppressed diabetic man. ( 24842101 )
2014
27
Gas gangrene in the diabetic foot: lessons learned from a salvaged limb. ( 24720142 )
2014
28
Fatal spontaneous Clostridium septicum gas gangrene: a possible association with iatrogenic gastric acid suppression. ( 24878026 )
2014
29
Analysis of genetic similarities between Clostridium perfringens isolates isolated from patients with gas gangrene and from hospital environment conducted with the use of the PFGE method. ( 24791817 )
2014
30
Gas gangrene presenting with back pain. ( 24811103 )
2014
31
Opioid analgesics stop the development of clostridial gas gangrene. ( 24550443 )
2014
32
A Fatal Spontaneous Gas Gangrene due to Clostridium perfringens during Neutropenia of Allogeneic Stem Cell Transplantation: Case Report and Literature Review. ( 25298910 )
2014
33
Fatal massive infectious gas gangrene in a liver transplant recipient. ( 24415557 )
2014
34
Gas gangrene: need for aggressive management in delayed presentation. ( 24787142 )
2014
35
Development of Clostridium septicum gas gangrene as an adverse effect of clindamycin-induced Clostridium difficile infection in a pediatric patient. ( 24590337 )
2014
36
Diagnosis of Gas Gangrene: Does a Discrepancy Exist between the Published Data and Practice. ( 24345706 )
2013
37
Gas Gangrene Caused By Clostridium Perfringens Involving the Liver, Spleen, and Heart in a Man 20 Years After an Orthotopic Liver Transplant: A Case Report. ( 23962047 )
2013
38
Foudroyant Course of an Extensive Clostridium septicum Gas Gangrene in a Diabetic Patient with Occult Carcinoma of the Colon. ( 23864974 )
2013
39
Sublingual gas gangrene after dental therapy. ( 24149284 )
2013
40
Sponge-like appearance of the liver parenchyma due to fatal intrauterine gas gangrene following mechanical abortion. ( 22772802 )
2013
41
Clostridium septicum gas gangrene in the orbit: a case report. ( 23203898 )
2013
42
Comprehensive treatment for gas gangrene of the limbs in earthquakes. ( 24157141 )
2013
43
Gas gangrene in the abdominal wall: a physician's nightmare. ( 23684577 )
2013
44
Clostridial abdominal gas gangrene masquerading as a bowel perforation in an advanced-stage ovarian cancer patient. ( 23494868 )
2013
45
Clostridium perfringens gas gangrene at a wrist intravenous line insertion. ( 24108766 )
2013
46
Foreign Body with Gas Gangrene in an Elderly Patient with Diabetes. ( 25009760 )
2013
47
Clostridium septicum gas gangrene in a previously healthy 8-year-old female with survival. ( 23583163 )
2013
48
Gas gangrene in orthopaedic patients. ( 24288638 )
2013
49
Co-infection with Toxoplasma gondii and Clostridium perfringens in a postpartum woman with uterine gas gangrene: a case report. ( 22487420 )
2012
50
Gas gangrene of the abdominal wall due to late-onset enteric fistula after polyester mesh repair of an incisional hernia. ( 20922446 )
2012

Variations for Gas Gangrene

Expression for Gas Gangrene

Search GEO for disease gene expression data for Gas Gangrene.

Pathways for Gas Gangrene

Pathways related to Gas Gangrene according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.67 DMD TNNI3 TNNT2
2 11.24 HSPG2 MYOD1 TNNI3 TNNT2
3 10.78 DMD MYOM1 TNNI3 TNNT2
4 10.43 DMD HSPG2

GO Terms for Gas Gangrene

Cellular components related to Gas Gangrene according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 sarcomere GO:0030017 9.33 MYOM1 TNNI3 TNNT2
2 troponin complex GO:0005861 9.32 TNNI3 TNNT2
3 cardiac myofibril GO:0097512 9.26 TNNI3 TNNT2
4 cardiac Troponin complex GO:1990584 8.96 TNNI3 TNNT2
5 myofibril GO:0030016 8.92 DMD MYOD1 TNNI3 TNNT2

Biological processes related to Gas Gangrene according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 skeletal muscle tissue development GO:0007519 9.43 DMD MYOD1
2 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.4 TNNI3 TNNT2
3 striated muscle contraction GO:0006941 9.37 MYOM1 TNNI3
4 regulation of muscle contraction GO:0006937 9.32 TNNI3 TNNT2
5 negative regulation of ATPase activity GO:0032780 9.26 TNNI3 TNNT2
6 myotube cell development GO:0014904 9.16 DMD MYOD1
7 cardiac muscle contraction GO:0060048 9.13 DMD TNNI3 TNNT2
8 muscle filament sliding GO:0030049 8.8 DMD TNNI3 TNNT2

Molecular functions related to Gas Gangrene according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 structural constituent of muscle GO:0008307 8.96 DMD MYOM1
2 troponin C binding GO:0030172 8.62 TNNI3 TNNT2

Sources for Gas Gangrene

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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