MCID: GSG001
MIFTS: 67

Gas Gangrene malady

Infectious diseases, Muscle diseases categories

Summaries for Gas Gangrene

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Sources:
9Disease Ontology, 35MedlinePlus, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Gangrene is the death of tissues in your body. it happens when a part of your body loses its blood supply. gangrene can happen on the surface of the body, such as on the skin, or inside the body, in muscles or organs. causes include serious injuries problems with blood circulation, such as atherosclerosis and peripheral arterial disease diabetes skin symptoms may include a blue or black color, pain, numbness, and sores that produce a foul-smelling discharge. if the gangrene is internal, you may run a fever and feel unwell, and the area may be swollen and painful. gangrene is a serious condition. it needs immediate attention. treatment includes surgery, antibiotics, and oxygen therapy. in severe cases an amputation may be necessary.

MalaCards: Gas Gangrene, also known as gangrene, is related to myocarditis and pancreatitis, and has symptoms including sepsis, gas production and myonecrosis. An important gene associated with Gas Gangrene is HSPG2 (heparan sulfate proteoglycan 2), and among its related pathways are Muscular Dystrophies and Dystrophin-Glycoprotein Complex and Glycerophospholipid biosynthesis. The drugs nitrofurazone and oxygen and the compounds phosphatidyl ethanol and scalaradial have been mentioned in the context of this disorder. Affiliated tissues include muscle tissue, skin and liver, and related mouse phenotypes are muscle and homeostasis/metabolism.

Disease Ontology:9 A commensal bacterial infectious disease that results in infection, located in muscle tissue, has material basis in clostridium perfringens, which produce gas that becomes trapped in the infected tissue. gas gangrene usually develops after injuries or surgery. the infection has symptom large blisters, has symptom pain in the infected area, has symptom myonecrosis, has symptom gas production, and has symptom sepsis.

Wikipedia:66 Gas gangrene (also known as \"Clostridial myonecrosis\", and \"Myonecrosis\") is a bacterial infection... more...

Aliases & Classifications for Gas Gangrene

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 32LifeMap Discoveryā„¢, 63UMLS, 35MedlinePlus, 59SNOMED-CT, 28ICD9CM, 36MeSH, 26ICD10
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Related Diseases for Gas Gangrene

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Gas Gangrene:



Diseases related to gas gangrene

Symptoms for Gas Gangrene

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9Disease Ontology
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Symptoms:

9
  • sepsis
  • gas production
  • myonecrosis
  • pain in the infected area
  • large blisters

Drugs & Therapeutics for Gas Gangrene

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discoveryā„¢, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Gas Gangrene

Drug clinical trials:

Search ClinicalTrials for Gas Gangrene

Search NIH Clinical Center for Gas Gangrene

Search CenterWatch for Gas Gangrene

Inferred drug relations via UMLS63/NDF-RT42:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Gas Gangrene cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Gas Gangrene:
Peripheral blood-derived hematopoietic stem cells for leg gangrene
Embryonic/Adult Cultured Cells Related to Gas Gangrene:
Peripheral blood-derived hematopoietic stem cells

Genetic Tests for Gas Gangrene

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Anatomical Context for Gas Gangrene

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Sources:
34MalaCards, 15FMA
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MalaCards organs/tissues related to Gas Gangrene:

34
Skin, Liver, Colon, Uterus, Heart, Bone, Brain, Pancreas, Breast, Small intestine, Eye, Monocytes, Skeletal muscle, Bone marrow, Appendix, Lung, Spleen

FMA organs/tissues related to Gas Gangrene:

15
Muscle tissue

Animal Models for Gas Gangrene or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Gas Gangrene:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053697.9DMD, INS, TNNT2, HSPG2, CHKB, CASQ1
2MP:00053767.2CASQ2, DMD, PIK3C2A, INS, TNNT2, CHKB
3MP:00053786.5RBM12, CASQ1, PLA2G1B, DMD, HSPG2, TNNT2

Publications for Gas Gangrene

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53PubMed
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Articles related to Gas Gangrene:

(show top 50)    (show all 494)
idTitleAuthorsYear
1
Gas gangrene in the abdominal wall: a physician's nightmare. (23684577)
2013
2
Causes of gas gangrene seen at the University of Nigeria Teaching Hospital, Enugu, Nigeria. (18453489)
2008
3
Mortality and diabetes mellitus in amputations of the lower limbs for gas gangrene: a case report. (18829608)
2008
4
Gas gangrene of the liver after a choledocho-jejunostomy. (18628626)
2008
5
Spontaneous, nontraumatic gas gangrene due to Clostridium perfringens. (16310394)
2006
6
Fulminant and fatal gas gangrene of the stomach in a healthy live liver donor. (15376309)
2004
7
Gas gangrene secondary to Clostridium perfringens in pediatric oncology patients. (15232247)
2004
8
Gas gangrene pyaemia with myocardial abscess formation--fatal outcome from a rare infection nowadays. (12909385)
2003
9
Gas gangrene following intramuscular injection of vitamin B-complex: report of a fatal case. (17657062)
2002
10
Non-clostridial gas gangrene caused by Klebsiella pneumoniae: a case report. (11525362)
2001
11
Metastatic gas gangrene of the leg due to acute emphysematous cholecystitis. (11713957)
2001
12
Small intestine perforation because of capacitive coupling as a cause of abdominal wall gas gangrene and clostridial sepsis after laparoscopic cholecystectomy. (11147921)
2000
13
Gas gangrene following intramuscular injection. (10862335)
1999
14
Structure of the key toxin in gas gangrene. (9699639)
1998
15
Role of hyperbaric oxygen therapy in the rapid control of gas gangrene infection and its toxaemia. (2097348)
1990
16
Aortitis due to metastatic gas gangrene. (2618068)
1989
17
Gas-gangrene following arthroscopic surgery. (2706057)
1989
18
Gas gangrene: certain diagnosis or certain death. (2598680)
1989
19
Penicillin allergy, gas gangrene and casualty treatment regime. (3193397)
1988
20
Adenocarcinoma of the colon presenting as lower extremity gas gangrene (metastatic myonecrosis). Case report. (3564828)
1986
21
Fatal nonclostridial gas gangrene in a diabetic: a case report and review of the literature. (3798149)
1986
22
Crepitation simulating gas gangrene. A case report. (3980513)
1985
23
Crepitation simulating gas gangrene. A case report. (4077916)
1985
24
Gas gangrene complicating open forearm fractures. Report of five cases. (833168)
1977
25
Hyperbaric oxygen therapy in anaerobic infections: gas gangrene. (1273078)
1976
26
Anesthetic considerations in patients with gas gangrene. (943986)
1976
27
Proceedings: Post-operative gas gangrene managed by hyperbaric oxygen. (1141310)
1975
28
Interconversion of bacterial agents causing botulism and gas gangrene. (165441)
1975
29
Gas gangrene-on the basis of 19 observations. Advantages of combining surgery with hyperbaric oxygen therapy. (4372493)
1974
30
Gas gangrene. (4353508)
1973
31
Gas gangrene of the extremities. (4683702)
1973
32
Clostridial (gas gangrene) infection in a general hospital. (4715764)
1973
33
Gas gangrene of the anterior abdominal wall. (4352173)
1973
34
The prevention of experimental Clostridium novyi and Cl. perfringens gas gangrene in high-velocity missile wounds by active immunisation. (4345766)
1972
35
Gas gangrene with tetanus. (5057281)
1972
36
Liability for gas gangrene. (5068301)
1972
37
The role of alpha-toxin of Clostridium perfringens in experimental gas gangrene in guinea pigs. (4345498)
1972
38
Gas gangrene panophthalmitis treated with hyperbaric oxygen. (5550538)
1971
39
Gas gangrene treated by hyperbaric oxygen. (5780645)
1969
40
Gas gangrene salpingo-oophoritis. (4295301)
1968
41
Activity of metronidazole against experimental tetanus and gas gangrene. (4302783)
1968
42
Perirectal gas gangrene. (5264647)
1967
43
A CASE OF GAS GANGRENE SUCCESSFULLY TREATED BY HYPERBARIC OXYGENATION. (14253542)
1965
44
VACCINATION OF MONKEYS AGAINST GAS GANGRENE CAUSED BY C1. PERFRINGENS UNDER CONDITIONS OF CHRONIC IRRADIATION. (14079336)
1963
45
ASSAY OF POTENCY OF THE PROPOSED FIFTH INTERNATIONAL STANDARD FOR GAS-GANGRENE ANTITOXIN (PERFRINGENS). (14107746)
1963
46
Gas gangrene following an intramuscular injection of concentrated liver extract. Report of case with fatal termination by fulminating Clostridium perfringens bacillus septicemia. (13872977)
1962
47
Significance of Clostridium welchii infections and their relationship to gas gangrene. (13785713)
1960
48
Experimental gas gangrene: effect of clostridial and staphylococcal toxoids on survival time. (13740508)
1960
49
Gas gangrene after the injection of adrenaline-in-oil, with a report of three cases. (13767243)
1960
50
Anasarca and leukemoid reaction complicating gas gangrene. (18909944)
1948

Variations for Gas Gangrene

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Expression for genes affiliated with Gas Gangrene

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gas Gangrene

Search GEO for disease gene expression data for Gas Gangrene.

Pathways for genes affiliated with Gas Gangrene

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Sources:
51PathCards, 54QIAGEN, 56Reactome, 39NCBI BioSystems Database, 31KEGG
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Pathways related to Gas Gangrene according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8DMD, HSPG2
2
Show member pathways
8.5PLA2G2A, PLA2G1B, CHKB, PIK3C2A
3
Show member pathways
7.9INS, HSPG2, CHKB, PLA2G1B, PLA2G2A, PIK3C2A

Compounds for genes affiliated with Gas Gangrene

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Sources:
46Novoseek, 12DrugBank, 3BitterDB, 62Tocris Bioscience, 30IUPHAR, 52PharmGKB, 25HMDB
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Compounds related to Gas Gangrene according to GeneCards/GeneDecks:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1phosphatidyl ethanol46 1211.0PLA2G2A, HSPG2
2scalaradial4610.0PLA2G1B, PLA2G2A
3bw755c4610.0PLA2G1B, PLA2G2A
4beta-hydroxybutyrate469.8CHKB, INS
5manoalide469.8HSPG2, PLA2G2A, PLA2G1B
6p-bromophenacyl bromide469.8PLA2G2A, HSPG2, PLA2G1B
71-oleoyl-2-acetyl-sn-glycerol469.8PLA2G1B, HSPG2, PLA2G2A
8aacocf3469.8HSPG2, PLA2G1B, PLA2G2A
9aristolochic acid46 310.8PLA2G2A, PLA2G1B, HSPG2
10quinacrine46 1210.7PLA2G1B, HSPG2, PLA2G2A
11ndga469.7PLA2G1B, PLA2G2A, HSPG2
12thallium469.7CHKB, PIK3C2A
13edelfosine46 6210.7PLA2G2A, PLA2G1B, HSPG2
14palmitate469.7INS, HSPG2, PLA2G2A
15alpha-hydroxybutyrate469.7PIK3C2A, CHKB
16glibenclamide46 30 52 6212.7INS, HSPG2, PLA2G1B
17melittin469.6PLA2G1B, PLA2G2A
18dantrolene30 46 1211.5PIK3C2A, HSPG2, CHKB
19myristic acid46 25 1211.5PLA2G2A, PLA2G1B, INS
20ptca469.5TNNT2, PIK3C2A, CHKB
21gemfibrozil30 46 1211.4INS, PIK3C2A, CHKB
22bezafibrate46 30 1211.4INS, PIK3C2A, CHKB
23uric acid46 2510.3PIK3C2A, INS, CHKB
24pge2469.3PLA2G1B, PLA2G2A, CHKB, HSPG2
25choline46 25 1211.2HSPG2, PIK3C2A, PLA2G2A, CHKB
26atorvastatin46 52 30 25 1213.1PLA2G2A, CHKB, PIK3C2A
27ascorbic acid46 2510.1PLA2G2A, CHKB, PIK3C2A, HSPG2
28prednisolone46 30 1211.1DMD, CHKB, PIK3C2A
29succinylcholine46 52 30 1212.1CHKB, PIK3C2A
30phospholipid469.1PLA2G2A, PLA2G1B, CHKB, HSPG2, DMD
31dexamethasone46 52 30 1212.0PLA2G2A, PLA2G1B, INS, CHKB, HSPG2
32epinephrine46 25 1211.0PLA2G2A, CHKB, INS, PIK3C2A
33ly294002469.0PLA2G2A, HSPG2, INS, PIK3C2A
34acetylcholine46 52 30 25 1213.0DMD, PIK3C2A, HSPG2, PLA2G2A
35thromboxane a246 259.9PIK3C2A, HSPG2, PLA2G1B, PLA2G2A
36cyclosporin a46 30 6210.9CHKB, PIK3C2A, DMD, PLA2G2A
37urea46 25 1210.9PIK3C2A, DMD, CHKB
38potassium46 25 1210.7PIK3C2A, CHKB, DMD, PLA2G1B
39glutamate468.7PIK3C2A, CHKB, HSPG2, INS, PLA2G2A
40glycogen46 259.7TNNT2, CHKB, DMD, INS, PIK3C2A
41arginine468.6PIK3C2A, PLA2G2A, CHKB, DMD, INS
42superoxide46 259.6PIK3C2A, CHKB, PLA2G1B, PLA2G2A
43atp46 309.4CHKB, HSPG2, DMD, PIK3C2A, PLA2G1B
44creatinine468.4PLA2G2A, CHKB, TNNT2, DMD, INS, PIK3C2A
45fatty acid468.3PLA2G2A, INS, TNNT2, CHKB, PLA2G1B, PIK3C2A
46lactate468.2INS, PLA2G2A, CHKB, PLA2G1B, TNNT2, PIK3C2A
47glycerol46 25 1210.2DMD, PIK3C2A, INS, CHKB, PLA2G1B, PLA2G2A
48alanine468.1TNNT2, PLA2G2A, DMD, PIK3C2A, INS, CHKB
49heparin46 30 25 1211.0PLA2G2A, PIK3C2A, TNNT2, DMD, HSPG2, CHKB
50calcium46 52 25 1210.1PLA2G1B, PIK3C2A, DMD, TNNT2, HSPG2, CHKB

GO Terms for genes affiliated with Gas Gangrene

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17Gene Ontology
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Biological processes related to Gas Gangrene according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumGO:0108809.9CASQ2, DMD
2regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionGO:0108819.8CASQ2, DMD
3regulation of skeletal muscle contraction by regulation of release of sequestered calcium ionGO:0148099.7DMD, CASQ1
4phosphatidylinositol acyl-chain remodelingGO:0361499.7PLA2G1B, PLA2G2A
5phosphatidylethanolamine acyl-chain remodelingGO:0361529.6PLA2G1B, PLA2G2A
6phosphatidylglycerol acyl-chain remodelingGO:0361489.5PLA2G2A, PLA2G1B
7glycerophospholipid biosynthetic processGO:0464749.5PLA2G2A, PLA2G1B, CHKB
8phosphatidylserine acyl-chain remodelingGO:0361509.3PLA2G1B, PLA2G2A
9phospholipid metabolic processGO:0066448.7PLA2G2A, PLA2G1B, CHKB, PIK3C2A
10small molecule metabolic processGO:0442818.0PLA2G1B, CHKB, HSPG2, INS, PIK3C2A, PLA2G2A

Molecular functions related to Gas Gangrene according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phospholipase A2 activityGO:0046239.6PLA2G2A, PLA2G1B
2calcium-dependent phospholipase A2 activityGO:0474989.3PLA2G2A, PLA2G1B
3calcium ion bindingGO:0055098.3CASQ2, CASQ1, PLA2G2A, PLA2G1B, DMD

Products for genes affiliated with Gas Gangrene

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gas Gangrene

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet