MCID: GSG001
MIFTS: 53

Gas Gangrene malady

Infectious category

Summaries for Gas Gangrene

Sources:
8Disease Ontology, 34MedlinePlus, 64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:34 Gangrene is the death of tissues in your body. it happens when a part of your body loses its blood supply. gangrene can happen on the surface of the body, such as on the skin, or inside the body, in muscles or organs. causes include serious injuries problems with blood circulation, such as atherosclerosis and peripheral arterial disease diabetes skin symptoms may include a blue or black color, pain, numbness, and sores that produce a foul-smelling discharge. if the gangrene is internal, you may run a fever and feel unwell, and the area may be swollen and painful. gangrene is a serious condition. it needs immediate attention. treatment includes surgery, antibiotics, and oxygen therapy. in severe cases an amputation may be necessary.

MalaCards: Gas Gangrene, also known as gangrene, is related to adenocarcinoma and antiphospholipid syndrome, and has symptoms including large blisters, pain in the infected area and myonecrosis. An important gene associated with Gas Gangrene is HSPG2 (heparan sulfate proteoglycan 2), and among its related pathways are Muscular Dystrophies and Dystrophin-Glycoprotein Complex and Non-integrin membrane-ECM interactions. The drugs pentoxifylline and nitrofurazone and the compounds guanidino and phosphatidyl ethanol have been mentioned in the context of this disorder. Affiliated tissues include muscle tissue and skin, and related mouse phenotypes are cardiovascular system and muscle.

Disease Ontology:8 A commensal bacterial infectious disease that results in infection, located in muscle tissue, has material basis in clostridium perfringens, which produce gas that becomes trapped in the infected tissue. gas gangrene usually develops after injuries or surgery. the infection has symptom large blisters, has symptom pain in the infected area, has symptom myonecrosis, has symptom gas production, and has symptom sepsis.

Wikipedia:64 Gas gangrene (also known as \"Clostridial myonecrosis\", and \"Myonecrosis\") is a bacterial infection... more...

Aliases & Classifications for Gas Gangrene

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 31LifeMap Discovery™, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH, 25ICD10
See all sources

Related Diseases for Gas Gangrene

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Gas Gangrene via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 236)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.6PLA2G2A, HSPG2
2antiphospholipid syndrome30.2HSPG2
3acute myocardial infarction30.1CHKB, ITGA2B, PIK3C2A, TNNI3, TNNT2
4acute pancreatitis30.1PLA2G1B, PLA2G2A
5vascular disease30.1TNNT2, TNNI3, PIK3C2A
6septic shock30.1PIK3C2A, PLA2G2A, PLA2G1B
7atherosclerosis30.1HSPG2, ITGA2B, INS, PLA2G2A, PLA2G1B
8primary hyperoxaluria30.0INS, PIK3C2A, TNNI3, TNNT2
9hypertrophic cardiomyopathy29.9TNNI3, TNNT2
10duchenne muscular dystrophy29.8TNNT2, TNNI3, DMD, PIK3C2A, CHKB
11panophthalmitis10.6
12necrotizing fasciitis10.4
13tetanus10.4
14burns10.4
15noma10.4
16sepsis10.3
17calciphylaxis10.3
18meningococcemia10.3
19appendicitis10.3
20purpura fulminans10.3
21emphysematous cholecystitis10.2
22cecum adenocarcinoma10.2
23clostridium perfringens infection10.2
24acalculous cholecystitis10.2
25n syndrome10.2
26cryoglobulinemia10.2
27meckel's diverticulum10.2
28polyarteritis nodosa10.2
29plasmodium falciparum malaria10.2
30vasculitis10.2
31thrombocytosis10.1
32thromboangiitis obliterans10.1
33priapism10.1
34spotted fever10.1
35stomatitis10.1
36skeletal muscle regeneration10.1
37peripheral vascular disease10.1
38crohn's disease10.1
39paralytic ileus10.1
40leukemoid reaction10.1
41cellulitis10.1
42congenital generalized lipodystrophy10.1
43aortitis10.1
44leukostasis10.1
45toxic myocarditis10.1
46septic arthritis10.1
47acute myocarditis10.1
48arthritis10.1
49botulism10.1
50clostridium septicum infection10.1

Graphical network of the top 20 diseases related to Gas Gangrene:



Diseases related to gas gangrene

Clinical Features for Gas Gangrene

Sources:
8Disease Ontology
See all sources


Symptoms:

8 (see all 5)
  • large blisters
  • pain in the infected area
  • myonecrosis
  • gas production
  • sepsis

Drugs & Therapeutics for Gas Gangrene

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Gas Gangrene

Drug clinical trials:

Search ClinicalTrials for Gas Gangrene

Search NIH Clinical Center for Gas Gangrene

Search CenterWatch for Gas Gangrene

Inferred drug relations via UMLS61/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Gas Gangrene cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Gas Gangrene:
Peripheral blood-derived hematopoietic stem cells for leg gangrene
Embryonic/Adult Cultured Cells Related to Gas Gangrene:
Peripheral blood-derived hematopoietic stem cells

Genetic Tests for Gas Gangrene

Anatomical Context for Gas Gangrene

Sources:
33MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Gas Gangrene:

33
Skin

FMA organs/tissues related to Gas Gangrene:

14
Muscle tissue

Animal Models for Gas Gangrene or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Gas Gangrene

Sources:
51PubMed
See all sources

Articles related to Gas Gangrene:

idTitleAuthorsYear
1
Gastric gangrene due to necrotizing gastritis. (22211043)
2011
2
A case of fatal emphysematous pyelonephritis presenting as lower limb gaseous gangrene. (19881463)
2009
3
Gangrene of the stomach: a case of acute necrotizing gastritis. (626304)
1978

Genetic Variations for Gas Gangrene

Expression for genes affiliated with Gas Gangrene

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Gas Gangrene

Search GEO for disease gene expression data for Gas Gangrene.

Pathways for genes affiliated with Gas Gangrene

Sources:
52QIAGEN, 54Reactome, 30KEGG, 38NCBI BioSystems Database
See all sources

Compounds for genes affiliated with Gas Gangrene

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 2BitterDB, 60Tocris Bioscience, 50PharmGKB, 24HMDB
See all sources

Compounds related to Gas Gangrene according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1guanidino4510.2CHKB, NEU1
2phosphatidyl ethanol45 1111.2PLA2G2A, HSPG2
3alpha-hydroxybutyrate4510.1PIK3C2A, CHKB
4N-Tridecanoic Acid1110.0PLA2G1B, PLA2G2A
5thallium4510.0PIK3C2A, CHKB
6bw755c4510.0PLA2G2A, PLA2G1B
7scalaradial4510.0PLA2G2A, PLA2G1B
8dantrolene45 29 1111.9CHKB, PIK3C2A, HSPG2
9manoalide459.9HSPG2, PLA2G2A, PLA2G1B
10p-bromophenacyl bromide459.9PLA2G1B, PLA2G2A, HSPG2
111-oleoyl-2-acetyl-sn-glycerol459.9HSPG2, PLA2G2A, PLA2G1B
12aacocf3459.9HSPG2, PLA2G2A, PLA2G1B
13aristolochic acid45 210.9PLA2G1B, PLA2G2A, HSPG2
14ptca459.9CHKB, PIK3C2A, TNNT2
15quinacrine45 1110.8HSPG2, PLA2G2A, PLA2G1B
16melittin459.8PLA2G1B, PLA2G2A
17ndga459.8HSPG2, PLA2G2A, PLA2G1B
18edelfosine45 6010.8PLA2G1B, PLA2G2A, HSPG2
19gemfibrozil45 29 1111.8PIK3C2A, CHKB, INS
20bezafibrate45 29 1111.7PIK3C2A, CHKB, INS
21succinylcholine45 29 1111.7CHKB, PIK3C2A
22gamma-hydroxybutyrate459.7CHKB, PIK3C2A
23glibenclamide45 29 50 6012.7HSPG2, INS, PLA2G1B
24choline45 11 2411.6PLA2G2A, CHKB, PIK3C2A, HSPG2
25beta-hydroxybutyrate459.6INS, CHKB
26uric acid45 2410.6PIK3C2A, CHKB, INS
27myristic acid45 11 2411.5PLA2G1B, PLA2G2A, INS
28palmitate459.5HSPG2, INS, PLA2G2A
29phosphatidylcholine459.5HSPG2, NEU1, PLA2G2A, PLA2G1B
30ascorbic acid45 2410.5HSPG2, PIK3C2A, CHKB, PLA2G2A
31epinephrine45 11 2411.4PIK3C2A, CHKB, INS, PLA2G2A
32phospholipid459.3HSPG2, DMD, CHKB, PLA2G2A, PLA2G1B
33ly294002459.2HSPG2, PIK3C2A, INS, PLA2G2A
34melphalan45 1110.2IL4I1, CHKB, PIK3C2A
35acetylcholine45 50 29 11 2413.2HSPG2, DMD, PIK3C2A, NEU1, PLA2G2A
36glycogen45 2410.1TNNT2, DMD, PIK3C2A, CHKB, INS
37potassium45 11 2411.0PLA2G1B, CHKB, PIK3C2A, DMD, TNNI3
38dexamethasone45 50 29 1111.9HSPG2, CHKB, INS, PLA2G2A, PLA2G1B
39fatty acid458.7TNNT2, PIK3C2A, CHKB, INS, PLA2G2A, PLA2G1B
40fibrinogen458.7PIK3C2A, ITGA2B, CHKB, INS, IL4I1
41thromboxane a245 249.5HSPG2, PIK3C2A, IL4I1, PLA2G2A, PLA2G1B
42h2o2458.5HSPG2, NEU1, CHKB, IL4I1, PLA2G2A, PLA2G1B
43glycerol45 11 2410.4PLA2G1B, DMD, PIK3C2A, NEU1, CHKB, INS
44arginine458.3DMD, PIK3C2A, CHKB, INS, IL4I1, PLA2G2A
45heparin45 29 11 2411.2HSPG2, TNNT2, DMD, PIK3C2A, NEU1, CHKB
46serine458.1HSPG2, DMD, ITGA2B, NEU1, INS, IL4I1
47alanine457.8HSPG2, TNNT2, DMD, PIK3C2A, CHKB, INS
48creatinine457.8TNNT2, TNNI3, DMD, PIK3C2A, CHKB, INS
49lactate457.7TNNT2, TNNI3, PIK3C2A, CHKB, INS, IL4I1
50calcium45 50 11 2410.1HSPG2, CASQ2, CASQ1, TNNT2, TNNI3, DMD

GO Terms for genes affiliated with Gas Gangrene

Sources:
16Gene Ontology
See all sources

Cellular components related to Gas Gangrene according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1troponin complexGO:00586110.0TNNI3, TNNT2

Biological processes related to Gas Gangrene according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of ATPase activityGO:03278010.1TNNI3, TNNT2
2regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumGO:0108809.9DMD, CASQ2
3muscle filament slidingGO:0300499.9DMD, TNNI3, TNNT2
4cardiac muscle contractionGO:0600489.8DMD, TNNI3, CASQ2
5regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionGO:0108819.8CASQ2, DMD
6phosphatidylinositol acyl-chain remodelingGO:0361499.7PLA2G2A, PLA2G1B
7regulation of skeletal muscle contraction by regulation of release of sequestered calcium ionGO:0148099.7CASQ1, DMD
8phosphatidylethanolamine acyl-chain remodelingGO:0361529.7PLA2G1B, PLA2G2A
9glycerophospholipid biosynthetic processGO:0464749.6CHKB, PLA2G2A, PLA2G1B
10phosphatidylglycerol acyl-chain remodelingGO:0361489.6PLA2G1B, PLA2G2A
11phosphatidylserine acyl-chain remodelingGO:0361509.4PLA2G1B, PLA2G2A
12phospholipid metabolic processGO:0066449.1PLA2G1B, PLA2G2A, CHKB, PIK3C2A
13small molecule metabolic processGO:0442818.3HSPG2, PIK3C2A, NEU1, CHKB, INS, PLA2G2A

Molecular functions related to Gas Gangrene according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1troponin C bindingGO:03017210.0TNNI3, TNNT2
2phospholipase A2 activityGO:0046239.7PLA2G1B, PLA2G2A
3calcium-dependent phospholipase A2 activityGO:0474989.6PLA2G1B, PLA2G2A
4calcium ion bindingGO:0055098.1CASQ2, CASQ1, DMD, PLA2G2A, PLA2G1B

Products for genes affiliated with Gas Gangrene

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gas Gangrene

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet