MCID: GSG001
MIFTS: 46

Gas Gangrene

Categories: Infectious diseases, Skin diseases

Aliases & Classifications for Gas Gangrene

MalaCards integrated aliases for Gas Gangrene:

Name: Gas Gangrene 38 12 52 42 14 69
Myonecrosis 12 69
Gas Bacillus Infection 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9159
ICD10 33 A48.0
ICD9CM 35 040.0
MeSH 42 D005738
UMLS 69 C0017105

Summaries for Gas Gangrene

Disease Ontology : 12 A commensal bacterial infectious disease that results_in infection, located in muscle tissue, has material basis in Clostridium perfringens, which produce gas that becomes trapped in the infected tissue. Gas gangrene usually develops after injuries or surgery. The infection has symptom large blisters, has symptom pain in the infected area, has symptom myonecrosis, has symptom gas production, and has symptom sepsis.

MalaCards based summary : Gas Gangrene, also known as myonecrosis, is related to adenocarcinoma and arteriovenous malformation, and has symptoms including muscle cramp, myoclonus and torticollis. An important gene associated with Gas Gangrene is HSPG2 (Heparan Sulfate Proteoglycan 2), and among its related pathways/superpathways are Striated Muscle Contraction and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Glyburide and Imidacloprid have been mentioned in the context of this disorder. Affiliated tissues include liver, colon and skin, and related phenotypes are Negative genetic interaction between BLM-/- and BLM+/+ and cardiovascular system

Wikipedia : 72 Gas gangrene (also known as clostridial myonecrosis and myonecrosis) is a bacterial infection that... more...

Related Diseases for Gas Gangrene

Diseases related to Gas Gangrene via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 113)
id Related Disease Score Top Affiliating Genes
1 adenocarcinoma 30.6 MB PIK3C2A
2 arteriovenous malformation 10.7 PIK3C2A TNNI3
3 global developmental delay-osteopenia-ectodermal defect syndrome 10.6 TNNI3 TNNT2
4 ophthalmia neonatorum 10.6 PIK3C2A TNNI3
5 pyrimidine metabolic disorder 10.6 PIK3C2A TNNI3
6 female breast upper-outer quadrant cancer 10.6 TNNI3 TNNT2
7 ostertagiasis 10.5 PIK3C2A TNNI3
8 visual snow syndrome 10.5 MB PIK3C2A
9 endometrial type cervical adenomyoma 10.5 MB PIK3C2A
10 velocardiofacial syndrome 10.5 MB PIK3C2A
11 parkinsonism with spasticity, x-linked 10.5 DMD PIK3C2A
12 inferior myocardial infarction 10.4 MB PIK3C2A
13 dermatofibrosarcoma protuberans 10.4 DMD HSPG2
14 hereditary choroidal atrophy 10.4 MB PIK3C2A
15 brachial plexus neuropathy 10.4 MB PIK3C2A
16 moved to 122000 10.4 MB TNNI3
17 rete ovarii adenoma 10.4 MB PIK3C2A
18 cardiomyopathy, dilated, 1d 10.4 DMD TNNT2
19 chorea gravidarum 10.4 MB PIK3C2A
20 plantar fasciitis 10.4 MB PIK3C2A
21 hyperandrogenism 10.4 MB TNNI3
22 lyme disease 10.3 DMD PIK3C2A
23 malignant hypertension 10.3 MB TNNI3
24 microphthalmia, isolated, with coloboma 7 10.3 MB PIK3C2A
25 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 10.3 MB PIK3C2A
26 properdin deficiency 10.2 DMD MB
27 polysyndactyly trigonocephaly agenesis of corpus callosum 10.2 MB PIK3C2A
28 mitochondrial dna depletion syndrome 12 10.2 MB PIK3C2A
29 oropharynx cancer 10.1 MB PIK3C2A
30 hemorrhagic disease due to alpha-1-antitrypsin pittsburgh mutation 10.1 DMD TNNI3 TNNT2
31 autoimmune disease of skin and connective tissue 10.1 DMD TNNI3 TNNT2
32 panophthalmitis 10.1
33 phosphoserine aminotransferase deficiency 10.0 MYOD1 PRF1
34 acute liver failure 10.0 MB PIK3C2A
35 hepatitis 10.0
36 fasciitis 10.0
37 necrotizing fasciitis 10.0
38 myopathy, distal, tateyama type 10.0 DMD MB PIK3C2A
39 nevus cavernosus 10.0 DMD HSPG2
40 bile duct sarcoma 10.0 MB MYOD1
41 spleen cancer 10.0 MB MYOD1
42 burns 9.9
43 tetanus 9.9
44 transitional cell carcinoma 9.9 MB MYOD1
45 mucinous ovarian cystadenoma 9.9 MB MYOD1
46 lung superior sulcus carcinoma 9.9 DMD MB TNNI3
47 embryonal extrahepatic bile duct rhabdomyosarcoma 9.9 MB MYOD1
48 lateral medullary syndrome 9.9 MB MYOD1
49 endodermal sinus tumor 9.9 MB MYOD1
50 cholecystitis 9.9

Comorbidity relations with Gas Gangrene via Phenotypic Disease Network (PDN):


Acute Cystitis Decubitus Ulcer
Deficiency Anemia Heart Disease
Peripheral Vascular Disease

Graphical network of the top 20 diseases related to Gas Gangrene:



Diseases related to Gas Gangrene

Symptoms & Phenotypes for Gas Gangrene

UMLS symptoms related to Gas Gangrene:


muscle cramp, myoclonus, torticollis

GenomeRNAi Phenotypes related to Gas Gangrene according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Negative genetic interaction between BLM-/- and BLM+/+ GR00255-A-1 8.92 HSPG2 MYOD1 TNNI3 TNNT2

MGI Mouse Phenotypes related to Gas Gangrene:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.06 DMD HSPG2 MB MYOD1 NEU1 PIK3C2A
2 growth/size/body region MP:0005378 10.02 CPE DMD HSPG2 MB MYOD1 NEU1
3 homeostasis/metabolism MP:0005376 9.97 MB MYOD1 NEU1 PIK3C2A PRF1 TNNT2
4 mortality/aging MP:0010768 9.81 DMD HSPG2 MB MYOD1 NEU1 PIK3C2A
5 liver/biliary system MP:0005370 9.56 DMD HSPG2 NEU1 PRF1
6 muscle MP:0005369 9.56 TNNI3 TNNT2 CPE DMD HSPG2 MB
7 respiratory system MP:0005388 9.1 DMD HSPG2 MB MYOD1 NEU1 TNNI3

Drugs & Therapeutics for Gas Gangrene

Drugs for Gas Gangrene (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glyburide Approved Phase 2,Phase 1 10238-21-8 3488
2
Imidacloprid Vet_approved Phase 2,Phase 1 105827-78-9 86418
3 Hypoglycemic Agents Phase 2,Phase 1
4 Antibodies Phase 2
5 gamma-Globulins Phase 2
6 Immunoglobulins Phase 2
7 Immunoglobulins, Intravenous Phase 2
8 Rho(D) Immune Globulin Phase 2
9
Carbon monoxide Approved Phase 1 630-08-0 281
10
Protein C Approved

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Glyburide Advantage in Malignant Edema and Stroke - Remedy Pharmaceuticals Unknown status NCT01794182 Phase 2 RP-1127 (Glyburide for Injection)
2 Glyburide Advantage in Malignant Edema and Stroke Pilot Completed NCT01268683 Phase 1, Phase 2 RP-1127 (Glyburide for injection)
3 Immunoglobulin for Necrotizing Soft Tissue Infections: a Randomised Controlled Trial Completed NCT02111161 Phase 2 IVIG (Privigen);Saline 0.9%
4 A Clinical Trial of the Clinical Effects of Hyperbaric Oxygen Therapy in Thai Autistic Children Completed NCT00670891 Phase 1
5 Modulation of Biomarkers in Patients With Flesh-eating Bacterial Infections After With Hyperbaric Oxygen Treatment Unknown status NCT02501382
6 Biomarkers in Patients With Flesh-eating Bacterial Infections Completed NCT02180906
7 Prognosis and Treatment of Necrotizing Soft Tissue Infections: A Prospective Cohort Study Recruiting NCT03147352
8 Hyperbaric Oxygen Therapy Registry Enrolling by invitation NCT02483650

Search NIH Clinical Center for Gas Gangrene

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Gas Gangrene cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Gas Gangrene:
Peripheral blood-derived hematopoietic stem cells for leg gangrene
Embryonic/Adult Cultured Cells Related to Gas Gangrene:
Peripheral blood-derived hematopoietic stem cells

Cochrane evidence based reviews: gas gangrene

Genetic Tests for Gas Gangrene

Anatomical Context for Gas Gangrene

MalaCards organs/tissues related to Gas Gangrene:

39
Liver, Colon, Skin, Uterus, Pancreas, Bone, Heart

Publications for Gas Gangrene

Articles related to Gas Gangrene:

(show top 50) (show all 542)
id Title Authors Year
1
Spontaneous C.A septicum gas gangrene: A literature review. ( 28780428 )
2017
2
Mode of action of plectasin-derived peptides against gas gangrene-associated Clostridium perfringens type A. ( 28934314 )
2017
3
Effect of continuous sub-culturing on infectivity of Clostridium perfringens ATCC13124 in mouse gas gangrene model. ( 28213749 )
2017
4
Anal Canal Gas Gangrene in Aplastic Anaemia: Rare yet Lethal Entity - A Caveat. ( 28936381 )
2017
5
Non-clostridial gas gangrene in a patient with poorly controlled type 2 diabetes mellitus on hemodialysis. ( 28871383 )
2017
6
Fatal liver gas gangrene after biliary surgery. ( 28783522 )
2017
7
Gas Gangrene of Different Origin Associated with Clostridium perfringens Type A in Three Patients Simultaneously Hospitalized in a Single Department of Orthopedics and Traumatology in Poland. ( 28735323 )
2017
8
A Recombinant Probiotic, Lactobacillus casei, Expressing the Clostridium perfringens I+-toxoid, as an Orally Vaccine Candidate Against Gas Gangrene and Necrotic Enteritis. ( 28401477 )
2017
9
Blackish haematuria and gas gangrene. ( 27272762 )
2016
10
CLOSTRIDIAL PARAPROCTITIS WITH GAS GANGRENE OF FRONT-LATERAL ABDOMINAL WALLS AND NECROTIC FASCIO-MYOSITIS (CASE REPORT). ( 27770534 )
2016
11
Iatrogenic non-clostridial gas gangrene - a case report. ( 26672772 )
2016
12
An Uncommon Cause of Gas Gangrene. ( 27713042 )
2016
13
Clostridial Gas Gangrene of the Abdominal Wall After Laparoscopic Cholecystectomy: A Case Report and Review. ( 27490157 )
2016
14
Radiological diagnosis of gas gangrene in a fetus at term. ( 27590386 )
2016
15
Uterine Perforation with Intra-Abdominal Clostridium perfringens Gas Gangrene: A Rare and Fatal Infection. ( 27274183 )
2016
16
Massive gas gangrene secondary to occult colon carcinoma. ( 27257452 )
2016
17
A case of acute onset postoperative gas gangrene caused by Clostridium perfringens. ( 27488346 )
2016
18
Retroperitoneal necrotizing fasciitis with gas gangrene, caused by perforated caecal diverticulitis. ( 25675887 )
2015
19
Vertebral osteomyelitis and epidural abscess caused by gas gangrene presenting with complete paraplegia: a case report. ( 25888739 )
2015
20
Gas Gangrene of the Diabetic Foot. ( 27159595 )
2015
21
Clinical Features of Non-clostridial Gas Gangrene and Risk Factors for In-hospital Mortality. ( 26369267 )
2015
22
Necrotizing myonecrosis secondary to hematogenous spread of gas gangrene following colonic perforation. ( 25787163 )
2015
23
Novel application of vacuum sealing drainage with continuous irrigation of potassium permanganate for managing infective wounds of gas gangrene. ( 26223928 )
2015
24
Clostridium septicum Gas Gangrene in Colon Cancer: Importance of Early Diagnosis. ( 26793397 )
2015
25
Improved vacuum sealing drainage in the treatment of gas gangrene: a case report. ( 26770624 )
2015
26
Hepatic gas gangrene. ( 25986279 )
2015
27
Retraction: Aeromonas species infection with severe clinical manifestation in Okinawa, Japan-association with gas gangrene. ( 26790486 )
2015
28
A case of freeze-dried gas gangrene antitoxin for the treatment of Clostridium perfringens sepsis. ( 25748160 )
2015
29
Clostridium Sacroiliitis (Gas Gangrene) Following Sacroiliac Joint Injection--Case Report and Review of the Literature. ( 26218953 )
2015
30
Interventions for treating gas gangrene. ( 26631369 )
2015
31
A case of nontraumatic gas gangrene in a common marmoset (Callithrix jacchus). ( 26156080 )
2015
32
Fatal massive infectious gas gangrene in a liver transplant recipient. ( 24415557 )
2014
33
Fatal retroperitoneal gas gangrene complicating colonoscopic polypectomy without bowel perforation in a healthy adult. ( 24676832 )
2014
34
Development of Clostridium septicum gas gangrene as an adverse effect of clindamycin-induced Clostridium difficile infection in a pediatric patient. ( 24590337 )
2014
35
Images in clinical medicine: Gas gangrene of a prosthetic hip. ( 25390742 )
2014
36
Gas gangrene presenting with back pain. ( 24811103 )
2014
37
A Fatal Spontaneous Gas Gangrene due to Clostridium perfringens during Neutropenia of Allogeneic Stem Cell Transplantation: Case Report and Literature Review. ( 25298910 )
2014
38
Opioid analgesics stop the development of clostridial gas gangrene. ( 24550443 )
2014
39
Analysis of genetic similarities between Clostridium perfringens isolates isolated from patients with gas gangrene and from hospital environment conducted with the use of the PFGE method. ( 24791817 )
2014
40
Gas gangrene in the diabetic foot: lessons learned from a salvaged limb. ( 24720142 )
2014
41
Gas gangrene: need for aggressive management in delayed presentation. ( 24787142 )
2014
42
Escherichia coli gas gangrene in an immunosuppressed diabetic man. ( 24842101 )
2014
43
Fatal spontaneous Clostridium septicum gas gangrene: a possible association with iatrogenic gastric acid suppression. ( 24878026 )
2014
44
Clostridium perfringens gas gangrene at a wrist intravenous line insertion. ( 24108766 )
2013
45
Sublingual gas gangrene after dental therapy. ( 24149284 )
2013
46
Foreign Body with Gas Gangrene in an Elderly Patient with Diabetes. ( 25009760 )
2013
47
Gas Gangrene Caused By Clostridium Perfringens Involving the Liver, Spleen, and Heart in a Man 20 Years After an Orthotopic Liver Transplant: A Case Report. ( 23962047 )
2013
48
Foudroyant Course of an Extensive Clostridium septicum Gas Gangrene in a Diabetic Patient with Occult Carcinoma of the Colon. ( 23864974 )
2013
49
Sponge-like appearance of the liver parenchyma due to fatal intrauterine gas gangrene following mechanical abortion. ( 22772802 )
2013
50
Gas gangrene in orthopaedic patients. ( 24288638 )
2013

Variations for Gas Gangrene

Expression for Gas Gangrene

Search GEO for disease gene expression data for Gas Gangrene.

Pathways for Gas Gangrene

Pathways related to Gas Gangrene according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.99 DMD TNNI3 TNNT2
2 10.91 HSPG2 MYOD1 TNNI3 TNNT2
3 10.43 DMD HSPG2

GO Terms for Gas Gangrene

Cellular components related to Gas Gangrene according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytoplasmic vesicle GO:0031410 9.54 CPE NEU1 PIK3C2A
2 secretory granule GO:0030141 9.32 CPE PLA2G2A
3 troponin complex GO:0005861 9.26 TNNI3 TNNT2
4 cardiac myofibril GO:0097512 9.16 TNNI3 TNNT2
5 cardiac Troponin complex GO:1990584 8.96 TNNI3 TNNT2
6 myofibril GO:0030016 8.92 DMD MYOD1 TNNI3 TNNT2

Biological processes related to Gas Gangrene according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.37 TNNI3 TNNT2
2 regulation of muscle contraction GO:0006937 9.32 TNNI3 TNNT2
3 negative regulation of ATPase activity GO:0032780 9.26 TNNI3 TNNT2
4 myotube cell development GO:0014904 9.16 DMD MYOD1
5 cardiac muscle contraction GO:0060048 9.13 DMD TNNI3 TNNT2
6 muscle filament sliding GO:0030049 8.8 DMD TNNI3 TNNT2

Molecular functions related to Gas Gangrene according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 troponin C binding GO:0030172 8.62 TNNI3 TNNT2

Sources for Gas Gangrene

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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