MCID: GSG001
MIFTS: 67

Gas Gangrene malady

Infectious diseases, Muscle diseases categories

Summaries for Gas Gangrene

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MedlinePlus:33 Gangrene is the death of tissues in your body. it happens when a part of your body loses its blood supply. gangrene can happen on the surface of the body, such as on the skin, or inside the body, in muscles or organs. causes include serious injuries problems with blood circulation, such as atherosclerosis and peripheral arterial disease diabetes skin symptoms may include a blue or black color, pain, numbness, and sores that produce a foul-smelling discharge. if the gangrene is internal, you may run a fever and feel unwell, and the area may be swollen and painful. gangrene is a serious condition. it needs immediate attention. treatment includes surgery, antibiotics, and oxygen therapy. in severe cases an amputation may be necessary.

MalaCards based summary: Gas Gangrene, also known as gangrene, is related to myocarditis and septic shock, and has symptoms including large blisters, pain in the infected area and myonecrosis. An important gene associated with Gas Gangrene is HSPG2 (heparan sulfate proteoglycan 2), and among its related pathways are Muscular Dystrophies and Dystrophin-Glycoprotein Complex and Glycerophospholipid biosynthesis. The drugs pentoxifylline and nitrofurazone and the compounds phosphatidyl ethanol and scalaradial have been mentioned in the context of this disorder. Affiliated tissues include muscle tissue, skin and liver, and related mouse phenotypes are muscle and homeostasis/metabolism.

Disease Ontology:9 A commensal bacterial infectious disease that results in infection, located in muscle tissue, has material basis in clostridium perfringens, which produce gas that becomes trapped in the infected tissue. gas gangrene usually develops after injuries or surgery. the infection has symptom large blisters, has symptom pain in the infected area, has symptom myonecrosis, has symptom gas production, and has symptom sepsis.

Wikipedia:64 Gas gangrene (also known as clostridial myonecrosis and myonecrosis) is a bacterial infection that... more...

Aliases & Classifications for Gas Gangrene

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Gas Gangrene, Aliases & Descriptions:

Name: Gas Gangrene 31 9 11 44 61
Gangrene 9 44 33 61
Gas Bacillus Infection 9 61
Clostridium Infections 61
 
Clostridium Infection 9
Muscle Necrosis 61
Myonecrosis 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Muscle diseases


External Ids:

Disease Ontology9 DOID:9159
ICD9CM28 040.0
MeSH34 D005738
ICD1026 R02, A48.0

Related Diseases for Gas Gangrene

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Diseases related to Gas Gangrene via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 275)
idRelated DiseaseScoreTop Affiliating Genes
1myocarditis30.3DMD, CHKB, TNNT2
2septic shock30.0PLA2G2A, PIK3C2A, PLA2G1B
3pneumonia30.0HSPG2, PLA2G1B, PIK3C2A
4acute myocardial infarction30.0TNNT2, CHKB, PIK3C2A
5myositis30.0CHKB, PIK3C2A, DMD
6pancreatitis29.9PLA2G2A, HSPG2, INS, PLA2G1B
7primary hyperoxaluria29.9TNNT2, PIK3C2A, INS
8neuropathy29.7DMD, INS, PIK3C2A
9atherosclerosis29.6PLA2G2A, PLA2G1B, HSPG2, INS
10ischemia29.1PLA2G1B, PLA2G2A, HSPG2, TNNT2, PIK3C2A, DMD
11myopathy28.8CHKB, CASQ1, CASQ2, INS, PIK3C2A, TNNT2
12fournier gangrene10.7
13panophthalmitis10.6
14burns10.5
15hepatitis10.5
16necrotizing fasciitis10.5
17fasciitis10.5
18tetanus10.5
19noma10.4
20adenocarcinoma10.4
21cholecystitis10.4
22meckel's diverticulum10.4
23purpura10.4
24diabetes mellitus10.3
25leukemia10.3
26peritonitis10.3
27sepsis10.3
28status asthmaticus10.3PIK3C2A
29calciphylaxis10.3
30meningococcemia10.3
31malaria10.3
32appendicitis10.3
33liver cirrhosis10.3
34neutropenia10.3
35emphysematous cholecystitis10.3
36colon cancer10.3
37esophagitis10.3
38vasculitis10.3
39creatine phosphokinase, elevated serum10.3PIK3C2A, CHKB
40disseminated intravascular coagulation10.2
41mastitis10.2
42abdominal wall defect10.2
43ectopic pregnancy10.2PIK3C2A, CHKB
44intermediate coronary syndrome10.2PIK3C2A, TNNT2
45antiphospholipid syndrome10.2
46cryoglobulinemia10.2
47acalculous cholecystitis10.2
48priapism10.2
49polyarteritis nodosa10.2
50membranous glomerulonephritis10.2HSPG2, PLA2G2A

Graphical network of the top 20 diseases related to Gas Gangrene:



Diseases related to gas gangrene

Symptoms for Gas Gangrene

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Symptoms:

 9
  • large blisters
  • pain in the infected area
  • myonecrosis
  • gas production
  • sepsis

Drugs & Therapeutics for Gas Gangrene

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Drug clinical trials:

Search ClinicalTrials for Gas Gangrene

Search NIH Clinical Center for Gas Gangrene

Inferred drug relations via UMLS61/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Gas Gangrene cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Gas Gangrene:
Peripheral blood-derived hematopoietic stem cells for leg gangrene
Embryonic/Adult Cultured Cells Related to Gas Gangrene:
Peripheral blood-derived hematopoietic stem cells

Genetic Tests for Gas Gangrene

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Anatomical Context for Gas Gangrene

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MalaCards organs/tissues related to Gas Gangrene:

32
Skin, Liver, Colon, Uterus, Bone, Brain, Heart, Eye, Small intestine, Pancreas, Breast, Bone marrow, Spleen, Skeletal muscle, Lung, Monocytes, Appendix, Neutrophil

FMA organs/tissues related to Gas Gangrene:

15
Muscle tissue

Animal Models for Gas Gangrene or affiliated genes

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MGI Mouse Phenotypes related to Gas Gangrene:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053697.9DMD, INS, TNNT2, HSPG2, CHKB, CASQ1
2MP:00053767.2CASQ2, DMD, PIK3C2A, INS, TNNT2, CHKB
3MP:00053786.5RBM12, CASQ1, PLA2G1B, DMD, HSPG2, TNNT2

Publications for Gas Gangrene

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Articles related to Gas Gangrene:

(show top 50)    (show all 502)
idTitleAuthorsYear
1
Development of Clostridium septicum gas gangrene as an adverse effect of clindamycin-induced Clostridium difficile infection in a pediatric patient. (24590337)
2014
2
Gas gangrene in the abdominal wall: a physician's nightmare. (23684577)
2013
3
Causes of gas gangrene seen at the University of Nigeria Teaching Hospital, Enugu, Nigeria. (18453489)
2008
4
Mortality and diabetes mellitus in amputations of the lower limbs for gas gangrene: a case report. (18829608)
2008
5
Gas gangrene of the liver after a choledocho-jejunostomy. (18628626)
2008
6
Spontaneous, nontraumatic gas gangrene due to Clostridium perfringens. (16310394)
2006
7
Fulminant and fatal gas gangrene of the stomach in a healthy live liver donor. (15376309)
2004
8
Gas gangrene secondary to Clostridium perfringens in pediatric oncology patients. (15232247)
2004
9
Gas gangrene pyaemia with myocardial abscess formation--fatal outcome from a rare infection nowadays. (12909385)
2003
10
Gas gangrene following intramuscular injection of vitamin B-complex: report of a fatal case. (17657062)
2002
11
Non-clostridial gas gangrene caused by Klebsiella pneumoniae: a case report. (11525362)
2001
12
Metastatic gas gangrene of the leg due to acute emphysematous cholecystitis. (11713957)
2001
13
Small intestine perforation because of capacitive coupling as a cause of abdominal wall gas gangrene and clostridial sepsis after laparoscopic cholecystectomy. (11147921)
2000
14
Gas gangrene following intramuscular injection. (10862335)
1999
15
Structure of the key toxin in gas gangrene. (9699639)
1998
16
Role of hyperbaric oxygen therapy in the rapid control of gas gangrene infection and its toxaemia. (2097348)
1990
17
Aortitis due to metastatic gas gangrene. (2618068)
1989
18
Gas-gangrene following arthroscopic surgery. (2706057)
1989
19
Gas gangrene: certain diagnosis or certain death. (2598680)
1989
20
Penicillin allergy, gas gangrene and casualty treatment regime. (3193397)
1988
21
Adenocarcinoma of the colon presenting as lower extremity gas gangrene (metastatic myonecrosis). Case report. (3564828)
1986
22
Fatal nonclostridial gas gangrene in a diabetic: a case report and review of the literature. (3798149)
1986
23
Crepitation simulating gas gangrene. A case report. (3980513)
1985
24
Crepitation simulating gas gangrene. A case report. (4077916)
1985
25
Gas gangrene complicating open forearm fractures. Report of five cases. (833168)
1977
26
Hyperbaric oxygen therapy in anaerobic infections: gas gangrene. (1273078)
1976
27
Anesthetic considerations in patients with gas gangrene. (943986)
1976
28
Proceedings: Post-operative gas gangrene managed by hyperbaric oxygen. (1141310)
1975
29
Interconversion of bacterial agents causing botulism and gas gangrene. (165441)
1975
30
Gas gangrene-on the basis of 19 observations. Advantages of combining surgery with hyperbaric oxygen therapy. (4372493)
1974
31
Gas gangrene. (4353508)
1973
32
Gas gangrene of the extremities. (4683702)
1973
33
Clostridial (gas gangrene) infection in a general hospital. (4715764)
1973
34
Gas gangrene of the anterior abdominal wall. (4352173)
1973
35
The prevention of experimental Clostridium novyi and Cl. perfringens gas gangrene in high-velocity missile wounds by active immunisation. (4345766)
1972
36
Gas gangrene with tetanus. (5057281)
1972
37
Liability for gas gangrene. (5068301)
1972
38
The role of alpha-toxin of Clostridium perfringens in experimental gas gangrene in guinea pigs. (4345498)
1972
39
Gas gangrene panophthalmitis treated with hyperbaric oxygen. (5550538)
1971
40
Gas gangrene treated by hyperbaric oxygen. (5780645)
1969
41
Gas gangrene salpingo-oophoritis. (4295301)
1968
42
Activity of metronidazole against experimental tetanus and gas gangrene. (4302783)
1968
43
Perirectal gas gangrene. (5264647)
1967
44
VACCINATION OF MONKEYS AGAINST GAS GANGRENE CAUSED BY C1. PERFRINGENS UNDER CONDITIONS OF CHRONIC IRRADIATION. (14079336)
1963
45
ASSAY OF POTENCY OF THE PROPOSED FIFTH INTERNATIONAL STANDARD FOR GAS-GANGRENE ANTITOXIN (PERFRINGENS). (14107746)
1963
46
Gas gangrene following an intramuscular injection of concentrated liver extract. Report of case with fatal termination by fulminating Clostridium perfringens bacillus septicemia. (13872977)
1962
47
Significance of Clostridium welchii infections and their relationship to gas gangrene. (13785713)
1960
48
Experimental gas gangrene: effect of clostridial and staphylococcal toxoids on survival time. (13740508)
1960
49
Gas gangrene after the injection of adrenaline-in-oil, with a report of three cases. (13767243)
1960
50
Anasarca and leukemoid reaction complicating gas gangrene. (18909944)
1948

Variations for Gas Gangrene

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Expression for genes affiliated with Gas Gangrene

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Expression patterns in normal tissues for genes affiliated with Gas Gangrene

Search GEO for disease gene expression data for Gas Gangrene.

Pathways for genes affiliated with Gas Gangrene

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Pathways related to Gas Gangrene according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8HSPG2, DMD
2
Show member pathways
8.5PLA2G2A, PLA2G1B, CHKB, PIK3C2A
3
Show member pathways
7.9PIK3C2A, INS, HSPG2, CHKB, PLA2G1B, PLA2G2A

Compounds for genes affiliated with Gas Gangrene

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Compounds related to Gas Gangrene according to GeneCards/GeneDecks:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1phosphatidyl ethanol44 1211.0PLA2G2A, HSPG2
2scalaradial4410.0PLA2G1B, PLA2G2A
3bw755c4410.0PLA2G1B, PLA2G2A
4beta-hydroxybutyrate449.8CHKB, INS
5manoalide449.8HSPG2, PLA2G2A, PLA2G1B
6p-bromophenacyl bromide449.8PLA2G2A, HSPG2, PLA2G1B
71-oleoyl-2-acetyl-sn-glycerol449.8PLA2G1B, HSPG2, PLA2G2A
8aacocf3449.8HSPG2, PLA2G1B, PLA2G2A
9aristolochic acid44 310.8PLA2G2A, PLA2G1B, HSPG2
10quinacrine44 1210.7PLA2G1B, HSPG2, PLA2G2A
11ndga449.7PLA2G1B, PLA2G2A, HSPG2
12thallium449.7CHKB, PIK3C2A
13edelfosine44 6010.7PLA2G2A, PLA2G1B, HSPG2
14palmitate449.7INS, HSPG2, PLA2G2A
15alpha-hydroxybutyrate449.7PIK3C2A, CHKB
16glibenclamide44 29 50 6012.7INS, HSPG2, PLA2G1B
17melittin449.6PLA2G1B, PLA2G2A
18dantrolene29 44 1211.5PIK3C2A, HSPG2, CHKB
19myristic acid44 25 1211.5PLA2G2A, PLA2G1B, INS
20ptca449.5TNNT2, PIK3C2A, CHKB
21gemfibrozil29 44 1211.4INS, PIK3C2A, CHKB
22bezafibrate44 29 1211.4INS, PIK3C2A, CHKB
23uric acid44 2510.3PIK3C2A, INS, CHKB
24pge2449.3PLA2G1B, PLA2G2A, CHKB, HSPG2
25choline44 25 1211.2HSPG2, PIK3C2A, PLA2G2A, CHKB
26atorvastatin44 50 29 25 1213.1PLA2G2A, CHKB, PIK3C2A
27ascorbic acid44 2510.1PLA2G2A, CHKB, PIK3C2A, HSPG2
28prednisolone44 29 1211.1DMD, CHKB, PIK3C2A
29succinylcholine44 50 29 1212.1CHKB, PIK3C2A
30phospholipid449.1PLA2G2A, PLA2G1B, CHKB, HSPG2, DMD
31dexamethasone44 50 29 1212.0PLA2G2A, PLA2G1B, INS, CHKB, HSPG2
32epinephrine44 25 1211.0PLA2G2A, CHKB, INS, PIK3C2A
33ly294002449.0PLA2G2A, HSPG2, INS, PIK3C2A
34acetylcholine44 50 29 25 1213.0DMD, PIK3C2A, HSPG2, PLA2G2A
35thromboxane a244 259.9PIK3C2A, HSPG2, PLA2G1B, PLA2G2A
36cyclosporin a44 29 6010.9CHKB, PIK3C2A, DMD, PLA2G2A
37urea44 25 1210.9PIK3C2A, DMD, CHKB
38potassium44 25 1210.7PIK3C2A, CHKB, DMD, PLA2G1B
39glutamate448.7PIK3C2A, CHKB, HSPG2, INS, PLA2G2A
40glycogen44 259.7TNNT2, CHKB, DMD, INS, PIK3C2A
41arginine448.6PIK3C2A, PLA2G2A, CHKB, DMD, INS
42superoxide44 259.6PIK3C2A, CHKB, PLA2G1B, PLA2G2A
43atp44 299.4CHKB, HSPG2, DMD, PIK3C2A, PLA2G1B
44creatinine448.4PLA2G2A, CHKB, TNNT2, DMD, INS, PIK3C2A
45fatty acid448.3PLA2G2A, INS, TNNT2, CHKB, PLA2G1B, PIK3C2A
46lactate448.2INS, PLA2G2A, CHKB, PLA2G1B, TNNT2, PIK3C2A
47glycerol44 25 1210.2DMD, PIK3C2A, INS, CHKB, PLA2G1B, PLA2G2A
48alanine448.1TNNT2, PLA2G2A, DMD, PIK3C2A, INS, CHKB
49heparin44 29 25 1211.0PLA2G2A, PIK3C2A, TNNT2, DMD, HSPG2, CHKB
50calcium44 50 25 1210.1PLA2G1B, PIK3C2A, DMD, TNNT2, HSPG2, CHKB

GO Terms for genes affiliated with Gas Gangrene

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Biological processes related to Gas Gangrene according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumGO:0108809.9CASQ2, DMD
2regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionGO:0108819.8DMD, CASQ2
3regulation of skeletal muscle contraction by regulation of release of sequestered calcium ionGO:0148099.7CASQ1, DMD
4phosphatidylinositol acyl-chain remodelingGO:0361499.7PLA2G1B, PLA2G2A
5phosphatidylethanolamine acyl-chain remodelingGO:0361529.6PLA2G2A, PLA2G1B
6phosphatidylglycerol acyl-chain remodelingGO:0361489.5PLA2G2A, PLA2G1B
7glycerophospholipid biosynthetic processGO:0464749.5CHKB, PLA2G1B, PLA2G2A
8phosphatidylserine acyl-chain remodelingGO:0361509.3PLA2G2A, PLA2G1B
9phospholipid metabolic processGO:0066448.7PLA2G2A, PLA2G1B, CHKB, PIK3C2A
10small molecule metabolic processGO:0442818.0PIK3C2A, INS, HSPG2, CHKB, PLA2G1B, PLA2G2A

Molecular functions related to Gas Gangrene according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phospholipase A2 activityGO:0046239.6PLA2G2A, PLA2G1B
2calcium-dependent phospholipase A2 activityGO:0474989.3PLA2G2A, PLA2G1B
3calcium ion bindingGO:0055098.3CASQ2, CASQ1, PLA2G2A, PLA2G1B, DMD

Products for genes affiliated with Gas Gangrene

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Sources for Gas Gangrene

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet