MCID: GSG001
MIFTS: 49

Gas Gangrene malady

Categories: Infectious diseases, Skin diseases, Muscle diseases

Aliases & Classifications for Gas Gangrene

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Aliases & Descriptions for Gas Gangrene:

Name: Gas Gangrene 33 11 13 48 37 66
Myonecrosis 11 66
 
Gas Bacillus Infection or Gangrene 11
Gas Bacillus Infection 11

Classifications:



External Ids:

Disease Ontology11 DOID:9159
ICD1028 A48.0
ICD9CM30 040.0
MeSH37 D005738

Summaries for Gas Gangrene

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Disease Ontology:11 A commensal bacterial infectious disease that results in infection, located in muscle tissue, has material basis in clostridium perfringens, which produce gas that becomes trapped in the infected tissue. gas gangrene usually develops after injuries or surgery. the infection has symptom large blisters, has symptom pain in the infected area, has symptom myonecrosis, has symptom gas production, and has symptom sepsis.

MalaCards based summary: Gas Gangrene, also known as myonecrosis, is related to anthrax disease and tubular renal disease-cardiomyopathy syndrome, and has symptoms including large blisters, pain in the infected area and myonecrosis. An important gene associated with Gas Gangrene is HSPG2 (Heparan Sulfate Proteoglycan 2), and among its related pathways are Muscular Dystrophies and Dystrophin-Glycoprotein Complex and Cardiac Progenitor Differentiation. Affiliated tissues include muscle tissue, liver and colon, and related mouse phenotypes are respiratory system and cardiovascular system.

Wikipedia:69 Gas gangrene (also known as clostridial myonecrosis and myonecrosis) is a bacterial infection that... more...

Related Diseases for Gas Gangrene

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Diseases related to Gas Gangrene via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 92)
idRelated DiseaseScoreTop Affiliating Genes
1anthrax disease11.2
2tubular renal disease-cardiomyopathy syndrome10.5TNNI3, TNNT2
3atrial standstill, digenic10.5TNNI3, TNNT2
4transient neonatal thrombocytopenia10.4TNNI3, TNNT2
5neuronal migration disorders10.4DMD, HSPG2
6myopathy, distal, 410.3DMD, MYOM1
7meige syndrome10.2TNNI3, TNNT2
8longitudinal vaginal septum10.2DMD, TNNI3, TNNT2
9autoimmune disease of skin and connective tissue10.2DMD, TNNI3, TNNT2
10panophthalmitis10.2
11ulcerative blepharitis10.1TNNI3, TNNT2
12hepatitis10.1
13fasciitis10.1
14necrotizing fasciitis10.1
15fletcher factor deficiency10.1DMD, MYOD1
16proliferating trichilemmal cyst10.1DMD, MB
17burns10.1
18tetanus10.1
19adenocarcinoma10.1
20central cloudy dystrophy of francois10.0MB, TNNI3
21ectodermal dysplasia10.0DMD, TNNI3, TNNT2
22cholecystitis10.0
23fungal meningitis10.0MB, TNNI3
24leukemia10.0
25peritonitis10.0
26malignant hypertension9.9MB, TNNI3
27testis sarcoma9.9MB, MYOD1
28transitional papilloma9.9MB, MYOD1
29subacute leukemia9.9MB, MYOD1
30prostate rhabdomyosarcoma9.9MB, MYOD1
31pediatric fibrosarcoma9.9MB, MYOD1
32liver cirrhosis9.9
33neutropenia9.9
34lymphoma9.9
35penicillin allergy9.9
36osteomyelitis9.9
37esophagitis9.9
38pancreatitis9.9
39myocarditis9.9
40emphysematous cholecystitis9.9
41vaginal yolk sac tumor9.9MB, MYOD1
42pulmonary plasma cell granuloma9.8MB, MYOD1
43omphalocele9.8MB, MYOD1
44orbit rhabdomyosarcoma9.8MB, MYOD1
45adult central nervous system primitive neuroectodermal neoplasm9.8MB, MYOD1
46vulvar sebaceous carcinoma9.8MB, MYOD1
47immunodeficiency 34, mycobacteriosis, x-linked9.8DMD, MB, TNNI3
48central nervous system rhabdomyosarcoma9.8MB, MYOD1
49colon carcinoma in situ9.7MB, TNNI3, TNNT2
50lung cancer9.7

Comorbidity relations with Gas Gangrene via Phenotypic Disease Network (PDN):


Peripheral Vascular DiseaseDeficiency Anemia
Heart DiseaseAcute Cystitis
Decubitus Ulcer

Graphical network of the top 20 diseases related to Gas Gangrene:



Diseases related to gas gangrene

Symptoms for Gas Gangrene

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Symptoms:

 11
  • large blisters
  • pain in the infected area
  • myonecrosis
  • gas production
  • sepsis

UMLS symptoms related to Gas Gangrene:


chest wall necrosis, muscle cramp, myoclonus, torticollis

Drugs & Therapeutics for Gas Gangrene

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Drugs for Gas Gangrene (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
GlyburidePhase 1, Phase 211010238-21-83488
Synonyms:
1-((P-(2-(5-chloro-O-Anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexylurea
1-((p-(2-(5-Chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexylurea
1-(P-(2-(5-chloro-2-Methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexylurea
1-(p-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexylurea
10238-21-8
5-Chloro-N-[4-(cyclohexylureidosulfonyl)phenethyl]-2-methoxybenzamide
5-chloro-N-(2-(4-((((Cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-methoxybenzamide
5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide
AB00051949
AC1L1G1Q
AC1Q44V7
AKOS001487495
Abbenclamide
Adiab
Apo-Glibenclamide
Azuglucon
BIDD:GT0239
BPBio1_000344
BRD-K36927236-001-06-0
BRN 2230085
BSPBio_000312
BSPBio_001351
BSPBio_003053
Bastiverit
Benclamin
Betanase
Betanese 5
Bio-0156
Bio1_000076
Bio1_000565
Bio1_001054
Bio2_000071
Bio2_000551
C07022
C23H28ClN3O5S
CAS-10238-21-8
CBiol_001790
CHEBI:5441
CHEMBL472
CID3488
CPD000058229
Calabren
Cytagon
D00336
D005905
DB01016
Daonil
Debtan
Dia-basan
Diabeta
Diabeta (TN)
Diabiphage
Dibelet
DivK1c_000481
Duraglucon
EINECS 233-570-6
EU-0100499
Euclamin
Euglucan
Euglucon
Euglucon 5
Euglucon N
Euglykon
G 0639
G0639_SIAL
G0639_SIGMA
G2539_SIAL
GBN 5
Gen-Glybe
Gewaglucon
Gilemal
Glamide
Glibadone
Gliban
Gliben
Gliben-Puren N
Glibenbeta
Glibenclamid AL
Glibenclamid Basics
Glibenclamid Fabra
Glibenclamid Genericon
Glibenclamid Heumann
Glibenclamid Riker M
Glibenclamid Riker M.
Glibenclamid-Cophar
Glibenclamid-Ratiopharm
Glibenclamida
Glibenclamida [INN-Spanish]
Glibenclamide
Glibenclamide (JP15/INN)
Glibenclamidum
Glibenclamidum [INN-Latin]
Glibenil
Glibens
Glibesyn
Glibet
Glibetic
Glibil
Gliboral
Glicem
Glidiabet
Glimel
Glimide
Glimidstata
Glisulin
Glitisol
Glubate
Gluben
Gluco-Tablimen
Glucobene
Glucohexal
Glucolon
Glucomid
Glucoremed
Glucoven
Glyben
Glybenclamide
Glybenzcyclamide
Glyburide
Glyburide (USP)
Glyburide (micronized)
Glyburide [USAN]
 
Glycolande
Glycomin
Glynase
Glynase (TN)
HB 419
HB 420
HB-419
HB-420
HB419
HB420
HMS1361D13
HMS1568P14
HMS1791D13
HMS1922L08
HMS1989D13
HMS2089L06
HMS2093P04
HMS501I03
Hemi-Daonil
Hexaglucon
Humedia
I06-0716
IDI1_000481
IDI1_033821
KBio1_000481
KBio2_000071
KBio2_000730
KBio2_002639
KBio2_003298
KBio2_005207
KBio2_005866
KBio3_000141
KBio3_000142
KBio3_002273
KBioGR_000071
KBioGR_001897
KBioSS_000071
KBioSS_000730
LS-159295
Lederglib
Libanil
Lisaglucon
Lopac-G-0639
Lopac0_000499
MLS000069721
MLS001077262
Malix
Maninil
Med-Glionil
Melix
Micronase
Micronase (TN)
Micronized glyburide
Miglucan
MolPort-000-784-850
N-(4-(2-(5-Chloro-2-methoxybenzamido)ethyl)phenylsulfonyl)-N'-cyclohexylurea
N-p-[2-(5-Chloro-2-methoxybenzamido)-ethyl]benzene-sulfonyl-N -cyclohexylurea
N-p-[2-(5-Chloro-2-methoxybenzamido)ethyl]benzenesulfonyl-N'-cyclohexylurea
NCGC00015467-01
NCGC00015467-02
NCGC00015467-06
NCGC00015467-16
NCGC00016689-01
NCGC00023447-02
NCGC00023447-04
NCGC00023447-05
NCGC00023447-06
NCGC00023447-07
NCGC00023447-08
NCGC00023447-09
NCGC00023447-10
NCGC00023447-11
NCGC00023447-12
NINDS_000481
Nadib
Neogluconin
Norglicem 5
Normoglucon
Novo-Glyburide
Oprea1_764617
Orabetic
Pira
Praeciglucon
PresTab
Prestwick0_000316
Prestwick1_000316
Prestwick2_000316
Prestwick3_000316
Prestwick_569
Probes1_000431
Probes2_000378
Prodiabet
Renabetic
S1716_Selleck
SAM002564212
SMR000058229
SPBio_001831
SPBio_002531
SPECTRUM2300229
SR-01000000196-5
STK362992
Semi-Daonil
Semi-Euglucon
Semi-Gliben-Puren N
Semi-daonil
Spectrum2_001816
Spectrum3_001327
Spectrum4_001199
Spectrum5_001631
Spectrum_000250
Sugril
Suraben
Tiabet
Tocris-0911
U 26452
U-26452
UNII-SX6K58TVWC
UPCMLD-DP006
UPCMLD-DP006:001
UR 606
Yuglucon
ZINC00537805
glibenclamide
glyburide
2
imidaclopridPhase 1, Phase 2154105827-78-986418
Synonyms:
(e)-imidacloprid
(z)-imidacloprid
1-((6-Chloro-3-pyridyl)methyl)-N-nitro-2-imidazolidinimine
1-(2-Chloro-5-pyridylmethyl)-2-(nitroimino)imidazolidine
1-[(6-Chloro-3-pyridinyl)methyl]-4,5-dihydro-N-nitro-1H-imidazol-2-amine, 9CI
Admire
Advantage
Advantage flea adulticide
Bayer brand of imidacloprid
 
Confidor
Confidor 200 SL
Confidor SL
Gaucho
Imidacloprid (old RN)
Imidacloprid [iso]
Merit
Merit (insecticide)
Premise 75
Provado
3
Carbon monoxidePhase 1108630-08-0281
Synonyms:
CO
 
Carbon monoxide
Carboneum oxygenisatum
carbon(II) oxide

Interventional clinical trials:

idNameStatusNCT IDPhase
1Immunoglobulin for Necrotizing Soft Tissue Infections: a Randomised Controlled TrialCompletedNCT02111161Phase 2
2Glyburide Advantage in Malignant Edema and Stroke PilotCompletedNCT01268683Phase 1, Phase 2
3Glyburide Advantage in Malignant Edema and Stroke - Remedy PharmaceuticalsActive, not recruitingNCT01794182Phase 2
4A Clinical Trial of the Clinical Effects of Hyperbaric Oxygen Therapy in Thai Autistic ChildrenCompletedNCT00670891Phase 1
5Biomarkers in Patients With Flesh-eating Bacterial InfectionsCompletedNCT02180906
6Modulation of Biomarkers in Patients With Flesh-eating Bacterial Infections After With Hyperbaric Oxygen TreatmentRecruitingNCT02501382
7Hyperbaric Oxygen Therapy RegistryEnrolling by invitationNCT02483650

Search NIH Clinical Center for Gas Gangrene

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Gas Gangrene cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Gas Gangrene:
Peripheral blood-derived hematopoietic stem cells for leg gangrene
Embryonic/Adult Cultured Cells Related to Gas Gangrene:
Peripheral blood-derived hematopoietic stem cells


Cochrane evidence based reviews: gas gangrene

Genetic Tests for Gas Gangrene

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Anatomical Context for Gas Gangrene

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MalaCards organs/tissues related to Gas Gangrene:

34
Liver, Colon, Skin, Uterus, Pancreas, Heart, Bone

FMA organs/tissues related to Gas Gangrene:

17
Muscle tissue

Animal Models for Gas Gangrene or affiliated genes

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MGI Mouse Phenotypes related to Gas Gangrene:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053887.8DMD, HSPG2, MB, MYOD1, NEU1, TNNI3
2MP:00053857.1DMD, HSPG2, MB, MYOD1, NEU1, TNNI3
3MP:00053697.0CPE, DMD, HSPG2, MB, MYOD1, NEU1
4MP:00053766.8CPE, DMD, HSPG2, MB, MYOD1, NEU1
5MP:00053786.5CPE, DMD, HSPG2, MB, MYOD1, NEU1

Publications for Gas Gangrene

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Articles related to Gas Gangrene:

(show top 50)    (show all 532)
idTitleAuthorsYear
1
Blackish haematuria and gas gangrene. (27272762)
2016
2
Clinical Features of Non-clostridial Gas Gangrene and Risk Factors for In-hospital Mortality. (26369267)
2015
3
Development of Clostridium septicum gas gangrene as an adverse effect of clindamycin-induced Clostridium difficile infection in a pediatric patient. (24590337)
2014
4
Analysis of genetic similarities between Clostridium perfringens isolates isolated from patients with gas gangrene and from hospital environment conducted with the use of the PFGE method. (24791817)
2014
5
Gas gangrene in the abdominal wall: a physician's nightmare. (23684577)
2013
6
Causes of gas gangrene seen at the University of Nigeria Teaching Hospital, Enugu, Nigeria. (18453489)
2008
7
Gas gangrene of the liver after a choledocho-jejunostomy. (18628626)
2008
8
Pathology of fatal traumatic and nontraumatic clostridial gas gangrene: a histopathological, immunohistochemical, and ultrastructural study of six autopsy cases. (17370083)
2008
9
The role of neutrophils and monocytic cells in controlling the initiation of Clostridium perfringens gas gangrene. (17428305)
2007
10
Spontaneous, nontraumatic gas gangrene due to Clostridium perfringens. (16310394)
2006
11
Metastatic breast cancer causing gas gangrene. (16716864)
2006
12
Fulminant and fatal gas gangrene of the stomach in a healthy live liver donor. (15376309)
2004
13
Gas gangrene pyaemia with myocardial abscess formation--fatal outcome from a rare infection nowadays. (12909385)
2003
14
Veno-atrial bypass for the operative treatment of septic gas gangrene secondary to delayed hepatic artery thrombosis. (12780569)
2003
15
Stress proteins of Clostridium perfringens type A immunoreact with antiserum from rabbits infected with gas gangrene. (12910385)
2003
16
Gas gangrene following intramuscular injection of vitamin B-complex: report of a fatal case. (17657062)
2002
17
Non-clostridial gas gangrene caused by Klebsiella pneumoniae: a case report. (11525362)
2001
18
Small intestine perforation because of capacitive coupling as a cause of abdominal wall gas gangrene and clostridial sepsis after laparoscopic cholecystectomy. (11147921)
2000
19
Gas gangrene following intramuscular injection. (10862335)
1999
20
Structure of the key toxin in gas gangrene. (9699639)
1998
21
The place of hyperbaric oxygen in the treatment of gas gangrene. (7613711)
1995
22
Gas gangrene from subcutaneous insulin administration. (8240568)
1993
23
Hepatic artery thrombosis resulting in gas gangrene of the transplanted liver. (1557692)
1992
24
Role of hyperbaric oxygen therapy in the rapid control of gas gangrene infection and its toxaemia. (2097348)
1990
25
Gas-gangrene following arthroscopic surgery. (2706057)
1989
26
Gas gangrene: certain diagnosis or certain death. (2598680)
1989
27
Penicillin allergy, gas gangrene and casualty treatment regime. (3193397)
1988
28
Comparison of single and combination antimicrobial agents for prevention of experimental gas gangrene caused by Clostridium perfringens. (2882732)
1987
29
Adenocarcinoma of the colon presenting as lower extremity gas gangrene (metastatic myonecrosis). Case report. (3564828)
1986
30
Survival after major burn complicated by gas gangrene, acute renal failure, and toxic myocarditis. (435749)
1979
31
Gas gangrene complicating open forearm fractures. Report of five cases. (833168)
1977
32
Gas gangrene complicating limb trauma. (1255823)
1976
33
Proceedings: Post-operative gas gangrene managed by hyperbaric oxygen. (1141310)
1975
34
Gas gangrene of the scrotum. (4823970)
1974
35
Clostridial (gas gangrene) infection in a general hospital. (4715764)
1973
36
The prevention of experimental Clostridium novyi and Cl. perfringens gas gangrene in high-velocity missile wounds by active immunisation. (4345766)
1972
37
Liability for gas gangrene. (5068301)
1972
38
Anaerobic streptococcal infections simulating gas gangrene. (5008911)
1972
39
Gas gangrene panophthalmitis treated with hyperbaric oxygen. (5550538)
1971
40
Gas gangrene treated by hyperbaric oxygen. (5780645)
1969
41
Gas gangrene complicating fracture of the tibia. (5820269)
1969
42
Gas gangrene salpingo-oophoritis. (4295301)
1968
43
Activity of metronidazole against experimental tetanus and gas gangrene. (4302783)
1968
44
Perirectal gas gangrene. (5264647)
1967
45
Gas gangrene of the heart in clostridial septicemia. (6047770)
1967
46
A CASE OF GAS GANGRENE SUCCESSFULLY TREATED BY HYPERBARIC OXYGENATION. (14253542)
1965
47
CLOSTRIDIAL GAS GANGRENE AND SEPTICEMIA IN MALIGNANT DISEASE. (14308223)
1965
48
Significance of Clostridium welchii infections and their relationship to gas gangrene. (13785713)
1960
49
Gas gangrene without visible portal of entry. (13844509)
1960
50
Anasarca and leukemoid reaction complicating gas gangrene. (18909944)
1948

Variations for Gas Gangrene

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Expression for genes affiliated with Gas Gangrene

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Search GEO for disease gene expression data for Gas Gangrene.

Pathways for genes affiliated with Gas Gangrene

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GO Terms for genes affiliated with Gas Gangrene

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Cellular components related to Gas Gangrene according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1troponin complexGO:000586110.0TNNI3, TNNT2
2myofibrilGO:00300168.9DMD, MYOD1, TNNI3, TNNT2
3sarcomereGO:00300178.9MYOM1, TNNI3, TNNT2

Biological processes related to Gas Gangrene according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1regulation of muscle contractionGO:000693710.0TNNI3, TNNT2
2negative regulation of ATPase activityGO:00327809.9TNNI3, TNNT2
3ventricular cardiac muscle tissue morphogenesisGO:00550109.9TNNI3, TNNT2
4myotube cell developmentGO:00149049.7DMD, MYOD1
5muscle filament slidingGO:00300499.4DMD, TNNI3, TNNT2
6cardiac muscle contractionGO:00600489.2DMD, TNNI3, TNNT2

Molecular functions related to Gas Gangrene according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1troponin C bindingGO:00301729.9TNNI3, TNNT2
2structural constituent of muscleGO:00083079.7DMD, MYOM1

Sources for Gas Gangrene

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet