Aliases & Classifications for Gas Gangrene

MalaCards integrated aliases for Gas Gangrene:

Name: Gas Gangrene 37 12 51 41 14 69
Myonecrosis 12 69
Gas Bacillus Infection 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9159
ICD10 32 A48.0
ICD9CM 34 040.0
MeSH 41 D005738

Summaries for Gas Gangrene

Disease Ontology : 12 A commensal bacterial infectious disease that results_in infection, located in muscle tissue, has material basis in Clostridium perfringens, which produce gas that becomes trapped in the infected tissue. Gas gangrene usually develops after injuries or surgery. The infection has symptom large blisters, has symptom pain in the infected area, has symptom myonecrosis, has symptom gas production, and has symptom sepsis.

MalaCards based summary : Gas Gangrene, also known as myonecrosis, is related to toxic myocarditis and myositis, and has symptoms including large blisters, pain in the infected area and myonecrosis. An important gene associated with Gas Gangrene is HSPG2 (Heparan Sulfate Proteoglycan 2), and among its related pathways/superpathways are Dilated cardiomyopathy (DCM) and Cardiac Progenitor Differentiation. The drugs Glyburide and Imidacloprid have been mentioned in the context of this disorder. Affiliated tissues include muscle tissue, liver and colon, and related phenotypes are Negative genetic interaction between BLM-/- and BLM+/+ and cardiovascular system

Related Diseases for Gas Gangrene

Diseases related to Gas Gangrene via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Related Disease Score Top Affiliating Genes
1 toxic myocarditis 29.9 PIK3C2A TNNI3
2 myositis 29.1 DMD MYOD1 PIK3C2A
3 anthrax disease 11.2
4 streptococcal group a invasive disease 11.1
5 tick paralysis 10.4 PIK3C2A TNNI3
6 familial isolated restrictive cardiomyopathy 10.3 TNNI3 TNNT2
7 myocardial stunning 10.2 TNNI3 TNNT2
8 panophthalmitis 10.2
9 extrinsic cardiomyopathy 10.1 PIK3C2A TNNI3
10 intermediate coronary syndrome 10.1 PIK3C2A TNNI3 TNNT2
11 hepatitis 10.1
12 fasciitis 10.1
13 necrotizing fasciitis 10.1
14 creatine phosphokinase, elevated serum 10.1 DMD PIK3C2A
15 acute myocardial infarction 10.1 PIK3C2A TNNI3 TNNT2
16 chromosome xp21 deletion syndrome 10.0 DMD PIK3C2A
17 burns 10.0
18 tetanus 10.0
19 adenocarcinoma 10.0
20 hemophagocytic lymphohistiocytosis, familial, 1 10.0 MYOD1 PRF1
21 diabetes mellitus 10.0
22 cholecystitis 10.0
23 cardiomyopathy, dilated, 1d 10.0 DMD TNNT2
24 muscular dystrophy-dystroglycanopathy , type b, 6 10.0 DMD HSPG2
25 leukemia 9.9
26 peritonitis 9.9
27 familial isolated dilated cardiomyopathy 9.9 DMD TNNI3 TNNT2
28 intrinsic cardiomyopathy 9.9 DMD TNNI3 TNNT2
29 myotonia 9.8 DMD HSPG2
30 enterocolitis 9.8
31 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 9.8
32 episodic pain syndrome, familial, 1 9.8
33 autoinflammation with infantile enterocolitis 9.8
34 liver cirrhosis 9.8
35 neutropenia 9.8
36 lymphoma 9.8
37 penicillin allergy 9.8
38 thrombosis 9.8
39 osteomyelitis 9.8
40 esophagitis 9.8
41 pancreatitis 9.8
42 myocarditis 9.8
43 emphysematous cholecystitis 9.8
44 atrial standstill 1 9.8 DMD TNNI3 TNNT2
45 muscle tissue disease 9.7 DMD MYOD1 PIK3C2A
46 ovarian cancer 9.7
47 small cell cancer of the lung 9.7
48 lung cancer 9.7
49 leprosy 3 9.7
50 body mass index quantitative trait locus 11 9.7

Comorbidity relations with Gas Gangrene via Phenotypic Disease Network (PDN):


Acute Cystitis Decubitus Ulcer
Deficiency Anemia Heart Disease
Peripheral Vascular Disease

Graphical network of the top 20 diseases related to Gas Gangrene:



Diseases related to Gas Gangrene

Symptoms & Phenotypes for Gas Gangrene

Symptoms:

12
  • large blisters
  • pain in the infected area
  • myonecrosis
  • gas production
  • sepsis

UMLS symptoms related to Gas Gangrene:


torticollis, myoclonus, muscle cramp

GenomeRNAi Phenotypes related to Gas Gangrene according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Negative genetic interaction between BLM-/- and BLM+/+ GR00255-A-1 8.92 HSPG2 MYOD1 TNNI3 TNNT2

MGI Mouse Phenotypes related to Gas Gangrene:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.92 DMD HSPG2 MYOD1 NEU1 PIK3C2A PRF1
2 growth/size/body region MP:0005378 9.91 CPE DMD HSPG2 MYOD1 NEU1 PIK3C2A
3 liver/biliary system MP:0005370 9.55 DMD HSPG2 NEU1 PRF1 CPE
4 muscle MP:0005369 9.5 TNNI3 TNNT2 CPE DMD HSPG2 MYOD1
5 nervous system MP:0003631 9.23 CPE DMD HSPG2 NEU1 PIK3C2A PRF1

Drugs & Therapeutics for Gas Gangrene

Drugs for Gas Gangrene (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glyburide Approved Phase 2,Phase 1 10238-21-8 3488
2
Imidacloprid Vet_approved Phase 2,Phase 1 105827-78-9 86418
3 Hypoglycemic Agents Phase 2,Phase 1
4 Antibodies Phase 2
5 gamma-Globulins Phase 2
6 Immunoglobulins Phase 2
7 Immunoglobulins, Intravenous Phase 2
8 Rho(D) Immune Globulin Phase 2
9
Carbon monoxide Approved, Investigational Phase 1 630-08-0 281
10
Protein C Approved

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Glyburide Advantage in Malignant Edema and Stroke - Remedy Pharmaceuticals Unknown status NCT01794182 Phase 2 RP-1127 (Glyburide for Injection)
2 Glyburide Advantage in Malignant Edema and Stroke Pilot Completed NCT01268683 Phase 1, Phase 2 RP-1127 (Glyburide for injection)
3 Immunoglobulin for Necrotizing Soft Tissue Infections: a Randomised Controlled Trial Completed NCT02111161 Phase 2 IVIG (Privigen);Saline 0.9%
4 A Clinical Trial of the Clinical Effects of Hyperbaric Oxygen Therapy in Thai Autistic Children Completed NCT00670891 Phase 1
5 Modulation of Biomarkers in Patients With Flesh-eating Bacterial Infections After With Hyperbaric Oxygen Treatment Unknown status NCT02501382
6 Biomarkers in Patients With Flesh-eating Bacterial Infections Completed NCT02180906
7 Prognosis and Treatment of Necrotizing Soft Tissue Infections: A Prospective Cohort Study Recruiting NCT03147352
8 Effects of Repetitive Hyperbaric Oxygen Therapy in Patients With Acute Ischaemic Stroke Recruiting NCT03431402 Hyperbaric oxygen
9 Hyperbaric Oxygen Therapy Registry Enrolling by invitation NCT02483650

Search NIH Clinical Center for Gas Gangrene

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Gas Gangrene cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Gas Gangrene:
Peripheral blood-derived hematopoietic stem cells for leg gangrene
Embryonic/Adult Cultured Cells Related to Gas Gangrene:
Peripheral blood-derived hematopoietic stem cells

Cochrane evidence based reviews: gas gangrene

Genetic Tests for Gas Gangrene

Anatomical Context for Gas Gangrene

The Foundational Model of Anatomy Ontology organs/tissues related to Gas Gangrene:

18
Muscle Tissue

MalaCards organs/tissues related to Gas Gangrene:

38
Liver, Colon, Uterus, Eye, Pancreas, Brain, Heart

Publications for Gas Gangrene

Articles related to Gas Gangrene:

(show top 50) (show all 544)
# Title Authors Year
1
Combined therapy with gas gangrene antitoxin and recombinant human soluble thrombomodulin for Clostridium perfringens sepsis in a rat model. ( 29246581 )
2018
2
Gas gangrene of the eye: endogenous <em>Clostridium perfringens</em> endophthalmitis. ( 29385972 )
2018
3
Gas Gangrene of Different Origin Associated with Clostridium perfringens Type A in Three Patients Simultaneously Hospitalized in a Single Department of Orthopedics and Traumatology in Poland. ( 28735323 )
2017
4
Spontaneous C.A septicum gas gangrene: A literature review. ( 28780428 )
2017
5
Anal Canal Gas Gangrene in Aplastic Anaemia: Rare yet Lethal Entity - A Caveat. ( 28936381 )
2017
6
Fatal liver gas gangrene after biliary surgery. ( 28783522 )
2017
7
Effect of continuous sub-culturing on infectivity of Clostridium perfringens ATCC13124 in mouse gas gangrene model. ( 28213749 )
2017
8
Mode of action of plectasin-derived peptides against gas gangrene-associated Clostridium perfringens type A. ( 28934314 )
2017
9
Non-clostridial gas gangrene in a patient with poorly controlled type 2 diabetes mellitus on hemodialysis. ( 28871383 )
2017
10
A Recombinant Probiotic, Lactobacillus casei, Expressing the Clostridium perfringens I+-toxoid, as an Orally Vaccine Candidate Against Gas Gangrene and Necrotic Enteritis. ( 28401477 )
2017
11
A case of acute onset postoperative gas gangrene caused by Clostridium perfringens. ( 27488346 )
2016
12
Uterine Perforation with Intra-Abdominal Clostridium perfringens Gas Gangrene: A Rare and Fatal Infection. ( 27274183 )
2016
13
Blackish haematuria and gas gangrene. ( 27272762 )
2016
14
An Uncommon Cause of Gas Gangrene. ( 27713042 )
2016
15
Radiological diagnosis of gas gangrene in a fetus at term. ( 27590386 )
2016
16
Massive gas gangrene secondary to occult colon carcinoma. ( 27257452 )
2016
17
CLOSTRIDIAL PARAPROCTITIS WITH GAS GANGRENE OF FRONT-LATERAL ABDOMINAL WALLS AND NECROTIC FASCIO-MYOSITIS (CASE REPORT). ( 27770534 )
2016
18
Iatrogenic non-clostridial gas gangrene - a case report. ( 26672772 )
2016
19
Clostridial Gas Gangrene of the Abdominal Wall After Laparoscopic Cholecystectomy: A Case Report and Review. ( 27490157 )
2016
20
Clostridium septicum Gas Gangrene in Colon Cancer: Importance of Early Diagnosis. ( 26793397 )
2015
21
Novel application of vacuum sealing drainage with continuous irrigation of potassium permanganate for managing infective wounds of gas gangrene. ( 26223928 )
2015
22
Interventions for treating gas gangrene. ( 26631369 )
2015
23
A case of freeze-dried gas gangrene antitoxin for the treatment of Clostridium perfringens sepsis. ( 25748160 )
2015
24
Vertebral osteomyelitis and epidural abscess caused by gas gangrene presenting with complete paraplegia: a case report. ( 25888739 )
2015
25
Necrotizing myonecrosis secondary to hematogenous spread of gas gangrene following colonic perforation. ( 25787163 )
2015
26
Clostridium Sacroiliitis (Gas Gangrene) Following Sacroiliac Joint Injection--Case Report and Review of the Literature. ( 26218953 )
2015
27
Gas Gangrene of the Diabetic Foot. ( 27159595 )
2015
28
Clinical Features of Non-clostridial Gas Gangrene and Risk Factors for In-hospital Mortality. ( 26369267 )
2015
29
Retraction: Aeromonas species infection with severe clinical manifestation in Okinawa, Japan-association with gas gangrene. ( 26790486 )
2015
30
Retroperitoneal necrotizing fasciitis with gas gangrene, caused by perforated caecal diverticulitis. ( 25675887 )
2015
31
Hepatic gas gangrene. ( 25986279 )
2015
32
A case of nontraumatic gas gangrene in a common marmoset (Callithrix jacchus). ( 26156080 )
2015
33
Improved vacuum sealing drainage in the treatment of gas gangrene: a case report. ( 26770624 )
2015
34
Fatal retroperitoneal gas gangrene complicating colonoscopic polypectomy without bowel perforation in a healthy adult. ( 24676832 )
2014
35
Fatal spontaneous Clostridium septicum gas gangrene: a possible association with iatrogenic gastric acid suppression. ( 24878026 )
2014
36
Fatal massive infectious gas gangrene in a liver transplant recipient. ( 24415557 )
2014
37
Analysis of genetic similarities between Clostridium perfringens isolates isolated from patients with gas gangrene and from hospital environment conducted with the use of the PFGE method. ( 24791817 )
2014
38
Gas gangrene presenting with back pain. ( 24811103 )
2014
39
Images in clinical medicine: Gas gangrene of a prosthetic hip. ( 25390742 )
2014
40
Gas gangrene: need for aggressive management in delayed presentation. ( 24787142 )
2014
41
A Fatal Spontaneous Gas Gangrene due to Clostridium perfringens during Neutropenia of Allogeneic Stem Cell Transplantation: Case Report and Literature Review. ( 25298910 )
2014
42
Gas gangrene in the diabetic foot: lessons learned from a salvaged limb. ( 24720142 )
2014
43
Opioid analgesics stop the development of clostridial gas gangrene. ( 24550443 )
2014
44
Escherichia coli gas gangrene in an immunosuppressed diabetic man. ( 24842101 )
2014
45
Development of Clostridium septicum gas gangrene as an adverse effect of clindamycin-induced Clostridium difficile infection in a pediatric patient. ( 24590337 )
2014
46
Clostridium septicum gas gangrene in the orbit: a case report. ( 23203898 )
2013
47
Clostridium perfringens gas gangrene at a wrist intravenous line insertion. ( 24108766 )
2013
48
Foreign Body with Gas Gangrene in an Elderly Patient with Diabetes. ( 25009760 )
2013
49
Clostridium septicum gas gangrene in a previously healthy 8-year-old female with survival. ( 23583163 )
2013
50
Gas Gangrene Caused By Clostridium Perfringens Involving the Liver, Spleen, and Heart in a Man 20 Years After an Orthotopic Liver Transplant: A Case Report. ( 23962047 )
2013

Variations for Gas Gangrene

Expression for Gas Gangrene

Search GEO for disease gene expression data for Gas Gangrene.

Pathways for Gas Gangrene

GO Terms for Gas Gangrene

Cellular components related to Gas Gangrene according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasmic vesicle GO:0031410 9.67 CPE NEU1 PIK3C2A PRF1
2 secretory granule GO:0030141 9.5 CPE DMD PLA2G2A
3 troponin complex GO:0005861 9.26 TNNI3 TNNT2
4 cardiac myofibril GO:0097512 9.16 TNNI3 TNNT2
5 cardiac Troponin complex GO:1990584 8.96 TNNI3 TNNT2
6 myofibril GO:0030016 8.92 DMD MYOD1 TNNI3 TNNT2

Biological processes related to Gas Gangrene according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 skeletal muscle tissue development GO:0007519 9.4 DMD MYOD1
2 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.37 TNNI3 TNNT2
3 regulation of muscle contraction GO:0006937 9.32 TNNI3 TNNT2
4 negative regulation of ATPase activity GO:0032780 9.26 TNNI3 TNNT2
5 myotube cell development GO:0014904 9.16 DMD MYOD1
6 cardiac muscle contraction GO:0060048 9.13 DMD TNNI3 TNNT2
7 muscle filament sliding GO:0030049 8.8 DMD TNNI3 TNNT2

Molecular functions related to Gas Gangrene according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 troponin C binding GO:0030172 8.62 TNNI3 TNNT2

Sources for Gas Gangrene

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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