MCID: GST040
MIFTS: 48

Gastric Adenocarcinoma malady

Gastrointestinal diseases category

Summaries for Gastric Adenocarcinoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Stomach cancer, or gastric cancer, refers to cancer arising from any part of the stomach. Stomach cancer... more...

MalaCards: Gastric Adenocarcinoma, also known as adenocarcinoma of stomach, is related to adenocarcinoma and esophagitis. An important gene associated with Gastric Adenocarcinoma is MIR27A (microRNA 27a), and among its related pathways are Integrin Pathway and Cell adhesion molecules (CAMs). The compounds 5-aza-2deoxycytidine and rabeprazole have been mentioned in the context of this disorder. Affiliated tissues include lymph node, colon and lung.

Aliases & Classifications for Gastric Adenocarcinoma

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8Disease Ontology, 10DISEASES, 60UMLS, 44Novoseek, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

gastric adenocarcinoma 8 10 60
adenocarcinoma of stomach 8
stomach adenocarcinoma 8
adenocarcinoma gastric 44


External Ids:

Disease Ontology8 DOID:3717
SNOMED-CT56 408647009
NCIt39 C4004

Related Diseases for Gastric Adenocarcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Gastric Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 126)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma32.1CEACAM7, SERPINB5, CLDN7, CLDN4, GAST, S100A2
2esophagitis30.9GAST
3squamous cell carcinoma30.6S100A2, CLDN4, CLDN7, SERPINB5, CEACAM7
4stomach cancer29.9CEACAM7, SERPINB5, CLDN4, GAST
5gastric lymphoma10.6
6gastric diffuse adenocarcinoma10.5
7gastritis10.5
8gastric signet ring cell adenocarcinoma10.4
9signet ring cell adenocarcinoma10.4
10peritonitis10.4
11acanthosis nigricans10.4
12gastric squamous cell carcinoma10.4
13mucinous adenocarcinoma10.4
14colon adenocarcinoma10.4
15meckel's diverticulum10.3
16gastrointestinal stromal tumor10.3
17gastric cardia adenocarcinoma10.3
18gastric ulcer10.2
19adenoma10.2
20breast adenocarcinoma10.2
21hepatitis10.2
22pancreatitis10.2
23atrophic gastritis10.2
24gastric papillary adenocarcinoma10.2
25gastroesophageal junction adenocarcinoma10.2
26peutz-jeghers syndrome10.2
27agammaglobulinemia10.2
28papillary adenocarcinoma10.2
29peptic ulcer10.2
30familial adenomatous polyposis10.1
31granulomatous gastritis10.1
32lymphocytic gastritis10.1
33linitis plastica10.1
34adenocarcinoma in situ10.1
35diffuse large b-cell lymphoma10.1
36cell type cancer10.1
37choriocarcinoma10.1
38glomerulonephritis10.1
39hodgkin's lymphoma10.1
40leukemia10.1
41obesity10.1
42panniculitis10.1
43thyroiditis10.1
44gastric adenocarcinoma and proximal polyposis of the stomach10.1
45dyskeratosis congenita10.0
46amenorrhea10.0
47gastric tubular adenocarcinoma10.0
48colon cancer10.0GAST, XAF1, SERPINB5, CEACAM7
49pancreatic cancer10.0GAST, CLDN4, SERPINB5, CEACAM7
50ovarian cancer10.0SERPINB5, CLDN4

Graphical network of the top 20 diseases related to Gastric Adenocarcinoma:



Diseases related to gastric adenocarcinoma

Clinical Features for Gastric Adenocarcinoma

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Drugs & Therapeutics for Gastric Adenocarcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Gastric Adenocarcinoma

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Anatomical Context for Gastric Adenocarcinoma

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32MalaCards
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MalaCards organs/tissues related to Gastric Adenocarcinoma:

32
Lymph node, Colon, Lung, Endothelial, T cells, Liver, Breast, Cervix, B cells, Bone, Testes, Prostate, Thyroid, Pancreas, Bone marrow, Whole blood, Spleen, Nk cells, Brain, Skeletal muscle, Placenta, Uterus, Salivary gland

Animal Models for Gastric Adenocarcinoma or affiliated genes

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Publications for Gastric Adenocarcinoma

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50PubMed
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Articles related to Gastric Adenocarcinoma:

(show top 50)    (show all 1102)
idTitleAuthorsYear
1
microRNA-449a functions as a tumor-suppressor in gastric adenocarcinoma by targeting Bcl-2. (24260067)
2013
2
Goiter frequency is more strongly associated with gastric adenocarcinoma than urine iodine level. (23844325)
2013
3
Decreased expression of transcription elongation factor A-like 7 is associated with gastric adenocarcinoma prognosis. (23372750)
2013
4
Upregulation of GPR34 expression affects the progression and prognosis of human gastric adenocarcinoma by PI3K/PDK1/AKT pathway. (23836308)
2013
5
Meta-Analysis of D1 Versus D2 Gastrectomy for Gastric Adenocarcinoma: Let Us Move on to Another Era. (24368663)
2013
6
Modern oncological approaches to gastric adenocarcinoma. (23639645)
2013
7
Gastric adenocarcinoma has a unique microRNA signature not present in esophageal adenocarcinoma. (23456798)
2013
8
Expression of I^-arrestin 1 in gastric cardiac adenocarcinoma and its relation with progression. (23317236)
2012
9
Mechanism of P-glycoprotein expression in the SGC7901 human gastric adenocarcinoma cell line induced by cyclooxygenase-2. (22901225)
2012
10
Simultaneous hepatocyte paraffin-1-positive I+-fetoprotein-producing gastric adenocarcinoma and gastric mucosal-associated lymphoid tissue. (21439873)
2012
11
Divergent expression of MUC5AC, MUC6, MUC2, CD10, and CDX-2 in dysplasia and intramucosal adenocarcinomas with intestinal and foveolar morphology: is this evidence of distinct gastric and intestinal pathways to carcinogenesis in Barrett Esophagus? (22261707)
2012
12
Small bowel adenocarcinoma copy number profiles are more closely related to colorectal than to gastric cancers. (21586687)
2012
13
Chylous ascites due to signet ring cell gastric adenocarcinoma. (23238204)
2012
14
PEA3/ETV4-related transcription factors coupled with active ERK signalling are associated with poor prognosis in gastric adenocarcinoma. (21673681)
2011
15
Unfound gastric signet ring-cell adenocarcinoma after gastric biopsy. (20425670)
2010
16
Long-Term Survival of Gastric Adenocarcinoma without Therapy: Case Report. (22043363)
2010
17
Diagnostic reproducibility in gastric-type mucinous adenocarcinoma of the uterine cervix: validation of novel diagnostic criteria. (20459563)
2010
18
Genetic polymorphisms in DNA repair genes XPC, XPD, and XRCC4, and susceptibility to Helicobacter pylori infection-related gastric antrum adenocarcinoma in Guangxi population, China. (20232359)
2010
19
Synchronous gastric adenocarcinoma and pancreatic ductal adenocarcinoma. (20133238)
2010
20
Epigenetic inactivation of deleted in lung and esophageal cancer 1 gene by promoter methylation in gastric and colorectal adenocarcinoma. (21443130)
2010
21
A positive family history of esophageal/gastric cardia cancer with gastric cardia adenocarcinoma is associated with a younger age at onset and more likely with another synchronous esophageal/gastric cardia cancer in a Chinese high-risk area. (20603233)
2010
22
Expression of activated signal transducer and activator of transcription 3 predicts poor clinical outcome in gastric adenocarcinoma. (19664131)
2009
23
Nonsteroidal antiinflammatory drugs and risk of gastric adenocarcinoma: the multiethnic cohort study. (19584132)
2009
24
Increased expression of fractalkine is correlated with a better prognosis and an increased number of both CD8+ T cells and natural killer cells in gastric adenocarcinoma. (18363071)
2008
25
Preoperative growth inhibition of human gastric adenocarcinoma treated with a combination of celecoxib and octreotide. (17959037)
2007
26
Promoter methylation of several tumor suppressor genes in human gastric adenocarcinoma]. (17650424)
2007
27
Cyclin D1 overexpression in N-methyl-N'-nitro-N-nitrosoguanidine-induced rat gastric adenocarcinomas. (17855062)
2007
28
Heme oxygenase-1 gene promoter polymorphism is associated with risk of gastric adenocarcinoma and lymphovascular tumor invasion. (17520317)
2007
29
The association of XRCC2 gene polymorphism with susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma in China]. (17922422)
2007
30
Variation in expression of gastric leptin according to differentiation and growth pattern in gastric adenocarcinoma. (16434209)
2006
31
Gastric signet-ring adenocarcinoma presenting with breast metastasis. (16718828)
2006
32
Helicobacter pylori induces mono-(adenosine 5'-diphosphate)-ribosylation in human gastric adenocarcinoma. (16964392)
2006
33
The expression of hepatocyte nuclear factor-4alpha, a developmental regulator of visceral endoderm, correlates with the intestinal phenotype of gastric adenocarcinomas. (17393984)
2006
34
Adenocarcinoma in bladder diverticulum, metastatic from gastric cancer. (16117837)
2005
35
Altered profiles of nuclear matrix proteins during the differentiation of human gastric mucous adenocarcinoma MGc80-3 cells. (16094700)
2005
36
Gastric mucinous adenocarcinoma with cutaneous metastases in a dog: diagnosis by fine-needle aspiration cytology. (16167597)
2005
37
Immunohistochemical expression of bcl-2, bcl-xL, bax, p53 proteins in gastric adenoma and adenocarcinoma]. (15973073)
2005
38
Arg tyrosine kinase expression in human gastric adenocarcinoma is associated with vessel invasion. (12680214)
2003
39
Malignant potential regarding mucin phenotypes and endocrine cell differentiation in gastric adenocarcinoma. (14666728)
2003
40
A functional polymorphism in the matrix metalloproteinase-2 gene promoter (-1306C/T) is associated with risk of development but not metastasis of gastric cardia adenocarcinoma. (12873995)
2003
41
Association of the HLA-DRB1 gene locus with gastric adenocarcinoma in Japan. (12870731)
2003
42
Branch retinal artery occlusion caused by an embolus of metastatic gastric adenocarcinoma. (12215097)
2002
43
Selective gene delivery toward gastric and esophageal adenocarcinoma cells via EpCAM-targeted adenoviral vectors. (11477454)
2001
44
Gastric adenocarcinoma of Meckel's diverticulum as a cause of colonic obstruction. (10917471)
2000
45
Coexistence of acanthosis nigricans and the sign of Leser-TrAclat in a patient with gastric adenocarcinoma: a case report and literature review. (10640933)
2000
46
Prospective study of gastric outlet obstruction in unresectable periampullary adenocarcinoma. (10594205)
2000
47
Epstein-Barr virus-associated gastric adenocarcinomas among Koreans. (8607441)
1996
48
Adenocarcinoma and atypical carcinoid: morphological study of a gastric collision-type tumour in the carcinoma-carcinoid spectrum. (8562996)
1995
49
The mutational status of p53 protein in gastric and esophageal adenocarcinoma cell lines predicts sensitivity to chemotherapeutic agents. (7665247)
1995
50
Antigen expression associated with lymph node metastasis in gastric adenocarcinomas. (7866567)
1994

Genetic Variations for Gastric Adenocarcinoma

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Expression for genes affiliated with Gastric Adenocarcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gastric Adenocarcinoma

Search GEO for disease gene expression data for Gastric Adenocarcinoma.

Pathways for genes affiliated with Gastric Adenocarcinoma

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51QIAGEN, 29KEGG, 53Reactome
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Compounds for genes affiliated with Gastric Adenocarcinoma

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB
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Compounds related to Gastric Adenocarcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
15-aza-2deoxycytidine4410.8SERPINB5, XAF1, S100A2
2rabeprazole44 49 11 2413.4ATP4B, GAST

GO Terms for genes affiliated with Gastric Adenocarcinoma

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16Gene Ontology
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Cellular components related to Gastric Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tight junctionGO:00592310.9CLDN6, CLDN7, CLDN4, CLDN9

Biological processes related to Gastric Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium-independent cell-cell adhesionGO:01633810.9CLDN6, CLDN7, CLDN4, CLDN9

Molecular functions related to Gastric Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:04280211.0CLDN6, CLDN7, CLDN4, CLDN9, S100A2
2structural molecule activityGO:00519810.6CLDN6, CLDN7, CLDN4, CLDN9

Products for genes affiliated with Gastric Adenocarcinoma

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Sources for Gastric Adenocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet