MCID: GST040
MIFTS: 48

Gastric Adenocarcinoma malady

Gastrointestinal diseases category

Summaries for Gastric Adenocarcinoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Stomach cancer, or gastric cancer, refers to cancer arising from any part of the stomach. Stomach cancer... more...

MalaCards: Gastric Adenocarcinoma, also known as adenocarcinoma of stomach, is related to adenocarcinoma and esophagitis. An important gene associated with Gastric Adenocarcinoma is MIR27A (microRNA 27a), and among its related pathways are Integrin Pathway and Tight junction. The compounds 5-aza-2deoxycytidine and rabeprazole have been mentioned in the context of this disorder. Affiliated tissues include lymph node, colon and lung.

Aliases & Classifications for Gastric Adenocarcinoma

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8Disease Ontology, 10DISEASES, 60UMLS, 44Novoseek, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

gastric adenocarcinoma 8 10 60
adenocarcinoma of stomach 8
stomach adenocarcinoma 8
adenocarcinoma gastric 44


External Ids:

Disease Ontology8 DOID:3717
SNOMED-CT56 408647009
NCIt39 C4004

Related Diseases for Gastric Adenocarcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Gastric Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 126)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma32.1CEACAM7, SERPINB5, CLDN7, CLDN4, GAST, S100A2
2esophagitis30.9GAST
3squamous cell carcinoma30.6S100A2, CLDN4, CLDN7, SERPINB5, CEACAM7
4stomach cancer29.9CEACAM7, SERPINB5, CLDN4, GAST
5gastric lymphoma10.6
6gastric diffuse adenocarcinoma10.5
7gastritis10.5
8gastric signet ring cell adenocarcinoma10.4
9signet ring cell adenocarcinoma10.4
10peritonitis10.4
11acanthosis nigricans10.4
12gastric squamous cell carcinoma10.4
13mucinous adenocarcinoma10.4
14colon adenocarcinoma10.4
15meckel's diverticulum10.3
16gastrointestinal stromal tumor10.3
17gastric cardia adenocarcinoma10.3
18gastric ulcer10.2
19adenoma10.2
20breast adenocarcinoma10.2
21hepatitis10.2
22pancreatitis10.2
23atrophic gastritis10.2
24gastric papillary adenocarcinoma10.2
25gastroesophageal junction adenocarcinoma10.2
26peutz-jeghers syndrome10.2
27agammaglobulinemia10.2
28papillary adenocarcinoma10.2
29peptic ulcer10.2
30familial adenomatous polyposis10.1
31granulomatous gastritis10.1
32lymphocytic gastritis10.1
33linitis plastica10.1
34adenocarcinoma in situ10.1
35diffuse large b-cell lymphoma10.1
36cell type cancer10.1
37choriocarcinoma10.1
38glomerulonephritis10.1
39hodgkin's lymphoma10.1
40leukemia10.1
41obesity10.1
42panniculitis10.1
43thyroiditis10.1
44gastric adenocarcinoma and proximal polyposis of the stomach10.1
45dyskeratosis congenita10.0
46amenorrhea10.0
47gastric tubular adenocarcinoma10.0
48colon cancer10.0GAST, XAF1, SERPINB5, CEACAM7
49pancreatic cancer10.0GAST, CLDN4, SERPINB5, CEACAM7
50ovarian cancer10.0SERPINB5, CLDN4

Graphical network of the top 20 diseases related to Gastric Adenocarcinoma:



Diseases related to gastric adenocarcinoma

Clinical Features for Gastric Adenocarcinoma

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Drugs & Therapeutics for Gastric Adenocarcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Gastric Adenocarcinoma

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Anatomical Context for Gastric Adenocarcinoma

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32MalaCards
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MalaCards organs/tissues related to Gastric Adenocarcinoma:

32
Lymph node, Colon, Lung, Endothelial, T cells, Liver, Breast, Cervix, B cells, Testes, Bone, Prostate, Pancreas, Thyroid, Brain, Spleen, Placenta, Nk cells, Uterus, Bone marrow, Whole blood, Skeletal muscle, Salivary gland

Animal Models for Gastric Adenocarcinoma or affiliated genes

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Publications for Gastric Adenocarcinoma

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50PubMed
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Articles related to Gastric Adenocarcinoma:

(show top 50)    (show all 1102)
idTitleAuthorsYear
1
Expression of bile acid receptor TGR5 in gastric adenocarcinoma. (23238937)
2013
2
Trends in the Surgical Treatment of Gastric Adenocarcinoma. (24165900)
2013
3
Primary esophageal adenocarcinoma arising from heterotopic gastric mucosa: report of a case. (22706784)
2013
4
Gastric Adenocarcinoma in Familial Adenomatous Polyposis Can Occur Without Previous Lesions. (23677534)
2013
5
ZNRF3 acts as a tumour suppressor by the Wnt signalling pathway in human gastric adenocarcinoma. (23504200)
2013
6
Infiltrating gastric adenocarcinoma with disseminated osteoblastic metastases. (23648509)
2013
7
A meta-analysis of body mass index and esophageal and gastric cardia adenocarcinoma. (22898040)
2013
8
Increased risk of gastric adenocarcinoma after treatment of primary gastric diffuse large B-cell lymphoma. (24159918)
2013
9
Hepatic resection for hepatic metastases from gastric adenocarcinoma. (23844322)
2013
10
Significance of glutathione peroxidase 1 and caudal-related homeodomain transcription factor in human gastric adenocarcinoma. (24228025)
2013
11
Gastric adenocarcinoma associated with gastritis cystica profunda in an unoperated stomach. (22856484)
2012
12
An unusual presentation of tumor lysis syndrome in a patient with advanced gastric adenocarcinoma: case report and literature review. (22685470)
2012
13
p16 gene mutations in Barrett's esophagus in gastric metaplasia - intestinal metaplasia - dysplasia - adenocarcinoma sequence. (22440936)
2012
14
DOK2 as a marker of poor prognosis of patients with gastric adenocarcinoma after curative resection. (22130622)
2012
15
A comprehensive review of S-1 in the treatment of advanced gastric adenocarcinoma. (21675835)
2011
16
Experienced versus inexperienced confocal endoscopists in the diagnosis of gastric adenocarcinoma and intestinal metaplasia on confocal images. (21492850)
2011
17
Roles of cyclin-dependent kinase 8 and I^-catenin in the oncogenesis and progression of gastric adenocarcinoma. (21344156)
2011
18
Clinicopathologic significance of gastric adenocarcinoma with neuroendocrine features. (22324009)
2011
19
Gastric adenocarcinoma in children and adolescents. (21744476)
2011
20
Serum levels of MMP-11 correlate with clinical outcome in Chinese patients with advanced gastric adenocarcinoma. (21513571)
2011
21
Gastrointestinal stromal tumor and gastric adenocarcinoma collision tumors. (20381123)
2010
22
Race and ethnicity correlate with survival in patients with gastric adenocarcinoma. (19622590)
2010
23
EBV-infection in cardiac and non-cardiac gastric adenocarcinomas is associated with promoter methylation of p16, p14 and APC, but not hMLH1. (20978327)
2010
24
Image of the month. Use of magnifying endoscopy to identify early esophageal adenocarcinoma in ectopic gastric mucosa of the cervical esophagus. (20347051)
2010
25
Gastric collision tumor of large cell neuroendocrine carcinoma and adenocarcinoma--a case report. (19945227)
2010
26
Critical role of aquaporin-3 in the human epidermal growth factor-induced migration and proliferation in the human gastric adenocarcinoma cells. (20364107)
2010
27
Adherence to a Mediterranean diet and risk of gastric adenocarcinoma within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study. (20007304)
2010
28
Coexistent gastric primary choriocarcinoma and adenocarcinoma. (19805966)
2009
29
Osteopontin, CD44, and NFkappaB expression in gastric adenocarcinoma. (19688069)
2009
30
Effects and mechanisms of proton pump inhibitors as a novel chemosensitizer on human gastric adenocarcinoma (SGC7901) cells. (19501661)
2009
31
Expression of p-Akt and COX-2 in gastric adenocarcinomas and adenovirus mediated Akt1 and COX-2 ShRNA suppresses SGC-7901 gastric adenocarcinoma and U251 glioma cell growth in vitro and in vivo. (19925030)
2009
32
Expression and clinical significance of focal adhesion kinase in the two distinct histological types, intestinal and diffuse, of human gastric adenocarcinoma. (18987997)
2009
33
Extreme aggressiveness and lethality of gastric adenocarcinoma in the very young. (19528381)
2009
34
Polymorphisms of the DNA repair gene XPA and XPC and its correlation with gastric cardiac adenocarcinoma in a high incidence population in North China. (18645534)
2008
35
Establishment and characterization of a cisplatin-resistant cell line (IGSK-1) from a poorly differentiated gastric adenocarcinoma. (17506773)
2007
36
Effect of vasoactive intestinal peptide on gastric adenocarcinoma. (17559364)
2007
37
Garlic oil inhibits cyclin E expression in gastric adenocarcinoma cells]. (17715037)
2007
38
Relationship between cytokine gene polymorphism and development of gastric adenocarcinoma]. (17672967)
2007
39
PTPN3 and PTPN4 tyrosine phosphatase expression in human gastric adenocarcinoma. (16619586)
2006
40
HTERT mRNA partially regulates telomerase activity in gastric adenocarcinoma and adjacent normal gastric mucosa. (16047476)
2005
41
"Big IGF-II"-induced hypoglycemia secondary to gastric adenocarcinoma. (15223980)
2004
42
Expression of regenerating gene I in gastric adenocarcinomas: correlation with tumor differentiation status and patient survival. (15022278)
2004
43
Expression of telomerase activity, human telomerase RNA, and telomerase reverse transcriptase in gastric adenocarcinomas. (12861067)
2003
44
HLA-DQA1 and -DQB1 genes and Helicobacter pylori infection in Italian patients with gastric adenocarcinoma. (11972882)
2002
45
Molecular and clinical differences between adenocarcinomas of the esophagus and of the gastric cardia. (11141476)
2001
46
Synchronous gastric adenocarcinomas in a patient with Meckel's diverticulum. (11418799)
2001
47
Synchronous and metachronous primary gastric lymphoma and adenocarcinoma: a clinicopathologic study of 12 patients. (9428501)
1998
48
Immunoelectron microscopic localization of carcinoembryonic antigen in gastric adenocarcinoma cell lines. (7952150)
1994
49
Gene amplification in gastric and esophageal adenocarcinomas. (2400999)
1990
50
Cytodiagnosis of gastric carcinoma, linitis plastica type (diffuse, infiltrating, poorly differentiated adenocarcinoma). (6269340)
1981

Genetic Variations for Gastric Adenocarcinoma

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Expression for genes affiliated with Gastric Adenocarcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gastric Adenocarcinoma

Search GEO for disease gene expression data for Gastric Adenocarcinoma.

Pathways for genes affiliated with Gastric Adenocarcinoma

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51QIAGEN, 29KEGG, 53Reactome
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Compounds for genes affiliated with Gastric Adenocarcinoma

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB
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Compounds related to Gastric Adenocarcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
15-aza-2deoxycytidine4410.8SERPINB5, XAF1, S100A2
2rabeprazole44 49 11 2413.4ATP4B, GAST

GO Terms for genes affiliated with Gastric Adenocarcinoma

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16Gene Ontology
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Cellular components related to Gastric Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tight junctionGO:00592310.9CLDN6, CLDN7, CLDN4, CLDN9

Biological processes related to Gastric Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium-independent cell-cell adhesionGO:01633810.9CLDN6, CLDN7, CLDN4, CLDN9

Molecular functions related to Gastric Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:04280211.0CLDN6, CLDN7, CLDN4, CLDN9, S100A2
2structural molecule activityGO:00519810.6CLDN6, CLDN7, CLDN4, CLDN9

Products for genes affiliated with Gastric Adenocarcinoma

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Sources for Gastric Adenocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet