MCID: GST040
MIFTS: 41

Gastric Adenocarcinoma malady

Summaries for Gastric Adenocarcinoma

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Stomach cancer, or gastric cancer, refers to cancer arising from any part of the stomach. Stomach cancer... more...

MalaCards: Gastric Adenocarcinoma, also known as adenocarcinoma of stomach, is related to adenocarcinoma and squamous cell carcinoma. An important gene associated with Gastric Adenocarcinoma is MIR27A (microRNA 27a), and among its related pathways are Integrin Pathway and Cell adhesion molecules (CAMs). The compounds 5-aza-2deoxycytidine and rabeprazole have been mentioned in the context of this disorder.

Aliases & Classifications for Gastric Adenocarcinoma

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 45Novoseek, 57SNOMED-CT, 40NCIt
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Aliases & Descriptions:

gastric adenocarcinoma 8 10 61
adenocarcinoma of stomach 8
stomach adenocarcinoma 8
adenocarcinoma gastric 45


External Ids:

Disease Ontology8 DOID:3717
SNOMED-CT57 408647009
NCIt40 C4004

Related Diseases for Gastric Adenocarcinoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Gastric Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 99)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma32.1CEACAM7, SERPINB5, CLDN7, CLDN4, GAST, S100A2
2squamous cell carcinoma30.6S100A2, CLDN4, CLDN7, SERPINB5, CEACAM7
3stomach cancer29.9CEACAM7, SERPINB5, CLDN4, GAST
4gastric lymphoma10.6
5h. pylori infection10.5
6gastric signet ring cell adenocarcinoma10.5
7signet ring cell adenocarcinoma10.5
8gastric cardia adenocarcinoma10.5
9acanthosis nigricans10.4
10gastric squamous cell carcinoma10.4
11esophageal squamous cell carcinoma10.4
12adenoma10.4
13gastrointestinal stromal tumor10.3
14gastric ulcer10.3
15breast adenocarcinoma10.3
16atrophic gastritis10.2
17meckel's diverticulum10.2
18linitis plastica10.2
19gastric papillary adenocarcinoma10.2
20gastroesophageal junction adenocarcinoma10.2
21peutz-jeghers syndrome10.2
22agammaglobulinemia10.2
23peutz–jeghers syndrome10.2
24hypoxia10.2
25gastric linitis plastica10.2
26small bowel adenocarcinoma10.2
27familial adenomatous polyposis10.1
28granulomatous gastritis10.1
29lymphocytic gastritis10.1
30n syndrome10.1
31lymphoma, diffuse large cell10.1
32peritoneal carcinoma10.1
33gastric adenocarcinoma and proximal polyposis of the stomach10.1
34dyskeratosis congenita10.1
35amenorrhea10.1
36gastric tubular adenocarcinoma10.1
37neuroendocrine carcinoma10.0
38colon cancer10.0GAST, XAF1, SERPINB5, CEACAM7
39pancreatic cancer10.0GAST, CLDN4, SERPINB5, CEACAM7
40ovarian cancer10.0SERPINB5, CLDN4
41papillary carcinoma10.0S100A2, CLDN4, SERPINB5
42esophagitis10.0GAST
43breast cancer10.0S100A2, CLDN4, CLDN7, CLDN6, SERPINB5, CEACAM7
44colorectal cancer10.0CEACAM7, SERPINB5, GAST
45breast reconstruction10.0
46branch retinal artery occlusion10.0
47neurofibromatosis10.0
48membranous glomerulonephritis10.0
49membranoproliferative glomerulonephritis10.0
50gastric leiomyoma10.0

Graphical network of the top 20 diseases related to Gastric Adenocarcinoma:



Diseases related to gastric adenocarcinoma

Clinical Features for Gastric Adenocarcinoma

Drugs & Therapeutics for Gastric Adenocarcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Gastric Adenocarcinoma

Drug clinical trials:

Search ClinicalTrials for Gastric Adenocarcinoma

Search NIH Clinical Center for Gastric Adenocarcinoma

Search CenterWatch for Gastric Adenocarcinoma

Genetic Tests for Gastric Adenocarcinoma

Anatomical Context for Gastric Adenocarcinoma

Animal Models for Gastric Adenocarcinoma or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Gastric Adenocarcinoma

Sources:
51PubMed
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Articles related to Gastric Adenocarcinoma:

(show top 50)    (show all 1102)
idTitleAuthorsYear
1
Protective autophagy is involved in resistance towards MET inhibitors in human gastric adenocarcinoma cells. (23313490)
2013
2
Aberrant methylation and loss expression of RKIP is associated with tumor progression and poor prognosis in gastric cardia adenocarcinoma. (22983529)
2013
3
Immunohistochemical expression and significance of NM23 suppressor protein in primary gastric adenocarcinoma. (23725501)
2013
4
Poly(I:C) exhibits an anti-cancer effect in human gastric adenocarcinoma cells which is dependent on RLRs. (24029594)
2013
5
Genetics/genomics/proteomics of gastric adenocarcinoma. (23639639)
2013
6
ORAOV1 is a probable target within the 11q13.3 amplicon in lymph node metastases from gastric adenocarcinoma. (21993861)
2012
7
HER2 expression in gastric and gastroesophageal junction adenocarcinoma in a US population: clinicopathologic analysis with proposed approach to HER2 assessment. (21617522)
2012
8
Expression of Yes-associated protein in gastric adenocarcinoma and inhibitory effects of its knockdown on gastric cancer cell proliferation and metastasis. (23058008)
2012
9
A meta-analysis on alcohol drinking and esophageal and gastric cardia adenocarcinoma risk. (21551004)
2012
10
ERCC1 gene +262A/C polymorphism associated with risk of gastric cardiac adenocarcinoma in nonsmokers. (22374244)
2012
11
Bimonthly regimen of high-dose leucovorin, infusional 5-fluorouracil, epirubicin and cisplatin (modified ECF) as adjuvant chemotherapy in resected gastric adenocarcinoma. (22832016)
2012
12
SEOM clinical guidelines for the diagnosis and treatment of gastric adenocarcinoma. (22721798)
2012
13
Quantitative expression analysis of the apoptosis-related genes BCL2, BAX and BCL2L12 in gastric adenocarcinoma cells following treatment with the anticancer drugs cisplatin, etoposide and taxol. (22238053)
2012
14
Xanthoxyletin, a coumarin induces S phase arrest and apoptosis in human gastric adenocarcinoma SGC-7901 cells. (21875271)
2011
15
Composite adenocarcinoma and carcinoid gastric tumor in chronic atrophic gastritis and pernicious anemia. (21552452)
2011
16
Meta-analysis of D1 versus D2 gastrectomy for gastric adenocarcinoma. (21394009)
2011
17
Florid cutaneous papillomatosis and acanthosis nigricans maligna revealing gastric adenocarcinoma. (21738980)
2011
18
Smoking and COX-2 functional polymorphisms interact to increase the risk of gastric cardia adenocarcinoma in Chinese population. (21779349)
2011
19
Cryptolepine, isolated from Sida acuta, sensitizes human gastric adenocarcinoma cells to TRAIL-induced apoptosis. (20623717)
2011
20
Epidemiology of noncardia gastric adenocarcinoma in the United States. (22008896)
2011
21
Type IV Borrmann gastric adenocarcinoma: analysis of curative resection results. (21971857)
2011
22
Cellular responses to chlorin-based photosensitizer DH-II-24 under darkness in human gastric adenocarcinoma AGS cells. (21205075)
2011
23
Adjuvant bi-weekly combination of cisplatin, infusional 5-fluorouracil and folinic acid followed by concomitant chemoradiotherapy with infusional fluorouracil for high risk operated gastric and gastroesophageal junction adenocarcinoma. (21338186)
2010
24
Expression level of Pre B cell leukemia homeobox 2 correlates with poor prognosis of gastric adenocarcinoma and esophageal squamous cell carcinoma. (20126986)
2010
25
Suppression of matrix metalloproteinase-9 expression by RNA interference inhibits SGC7901 gastric adenocarcinoma cell growth and invasion in vitro and in vivo. (19680827)
2010
26
A case of intestinal-type gastric adenocarcinoma metastatic to a caecal tubulovillous polyp. (20717182)
2010
27
The prognostic significance of whole blood global and specific DNA methylation levels in gastric adenocarcinoma. (21203466)
2010
28
Significant association between EGFR-mutated lung adenocarcinoma and past illness from gastric cancer or uterine myoma: its implication in carcinogenesis. (19362747)
2009
29
Differences in the definitions used for esophageal and gastric diseases in different countries: endoscopic definition of the esophagogastric junction, the precursor of Barrett's adenocarcinoma, the definition of Barrett's esophagus, and histologic criteria for mucosal adenocarcinoma or high-grade dysplasia. (19828957)
2009
30
Correlation between aneuploidy of chromosome 17, over-expression of TP53 and TOPIIalpha, and the clinicopathological features and diagnosis of gastric adenocarcinoma]. (20021828)
2009
31
Neoplastic meningitis as the presenting manifestation of gastric adenocarcinoma. (21785656)
2009
32
Hepatic metastases of gastric adenocarcinoma showing metabolic remission on FDG-PET despite an increase in size on CT. (19707508)
2009
33
Expression and localization of ATP binding cassette (ABC) family of drug transporters in gastric hepatoid adenocarcinomas. (18439156)
2008
34
Interrelationship between MYC gene numerical aberrations and protein expression in individuals from northern Brazil with early gastric adenocarcinoma. (18262050)
2008
35
Synchronous occurrence of a primary colon adenocarcinoma and a gastric stromal tumor. A case report. (18299673)
2008
36
Papillary adenocarcinoma occurring in a gastric hyperplastic polyp observed by magnifying endoscopy and treated with endoscopic mucosal resection. (18480580)
2008
37
Lysophosphatidic acid inhibits ghrelin secretion in the human gastric adenocarcinoma AGS cell line: role of mitogenic activated protein kinase signaling pathway. (17937769)
2007
38
Superoxide dismutase in gastric adenocarcinoma: is it a clinical biomarker in the development of cancer? (17056476)
2006
39
Expression of Pdx-1 in human gastric metaplasia and gastric adenocarcinoma. (16938521)
2006
40
Correlations between serine hydroxymethyltransferase1 C1420T polymorphisms and susceptibilities to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma]. (16536979)
2006
41
Lymph node metastasis from gastric carcinoid tumors occurring concomitantly with gastric adenocarcinomas and atrophic gastritis. (16504886)
2006
42
Promoter hypermethylation of the p16 gene in pre- and post-gastrectomy plasma of patients with gastric adenocarcinoma]. (15968314)
2005
43
Expression of p53 protein and DNA flow cytometry in gastric adenocarcinoma: implications in patients treated with adjuvant etoposide, adriamycin and cisplatin. (16277093)
2005
44
Expression of nuclear factor-kappa B and target genes in gastric precancerous lesions and adenocarcinoma: association with Helicobactor pylori cagA (+) infection. (14966904)
2004
45
Effect of apoptosis on gastric adenocarcinoma cell line SGC-7901 induced by cis-9, trans-11-conjugated linoleic acid. (12439913)
2002
46
Adenocarcinoma of the upper esophagus arising in heterotopic gastric mucosa: common pathogenesis with Barrett's adenocarcinoma? (12516606)
2002
47
Prospective evaluation of the prevalence of gastric Helicobacter pylori infection in patients with GERD, Barrett's esophagus, Barrett's dysplasia, and Barrett's adenocarcinoma. (10685740)
2000
48
A phase II study of 5-fluorouracil, leucovorin, adriamycin, and cisplatin (FLAP) for metastatic gastric and gastroesophageal junction adenocarcinoma. A Penn Cancer Clinical Trial Group and Roswell Park Cancer Institute Community Oncology Research Program Trial. (9167745)
1997
49
Increased estrogen receptor and epidermal growth factor receptor gene product co-expression in surgically resected gastric adenocarcinomas. (8944060)
1996
50
Thymidylate synthase protein expression: Association with response to neoadjuvant chemotherapy and resection for locally advanced gastric and gastroesophageal adenocarcinoma. (9166454)
1995

Genetic Variations for Gastric Adenocarcinoma

Expression for genes affiliated with Gastric Adenocarcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gastric Adenocarcinoma

Search GEO for disease gene expression data for Gastric Adenocarcinoma.

Pathways for genes affiliated with Gastric Adenocarcinoma

Sources:
52QIAGEN, 30KEGG, 54Reactome
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Compounds for genes affiliated with Gastric Adenocarcinoma

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB
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Compounds related to Gastric Adenocarcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
15-aza-2deoxycytidine4510.8SERPINB5, XAF1, S100A2
2rabeprazole45 50 11 2413.4ATP4B, GAST

GO Terms for genes affiliated with Gastric Adenocarcinoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Gastric Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tight junctionGO:00592310.9CLDN6, CLDN7, CLDN4, CLDN9

Biological processes related to Gastric Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium-independent cell-cell adhesionGO:01633810.9CLDN6, CLDN7, CLDN4, CLDN9

Molecular functions related to Gastric Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:04280211.0CLDN6, CLDN7, CLDN4, CLDN9, S100A2
2structural molecule activityGO:00519810.6CLDN6, CLDN7, CLDN4, CLDN9

Products for genes affiliated with Gastric Adenocarcinoma

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Sources for Gastric Adenocarcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet