GAVE
MCID: GST020
MIFTS: 33

Gastric Antral Vascular Ectasia (GAVE) malady

Categories: Rare diseases, Cardiovascular diseases, Gastrointestinal diseases

Aliases & Classifications for Gastric Antral Vascular Ectasia

Aliases & Descriptions for Gastric Antral Vascular Ectasia:

Name: Gastric Antral Vascular Ectasia 12 50 42 14
Watermelon Stomach 12 50
Gave 50

Classifications:



External Ids:

Disease Ontology 12 DOID:2493
MeSH 42 D020252
NCIt 47 C84724
SNOMED-CT 64 412795008 43935004
UMLS 69 C0267211

Summaries for Gastric Antral Vascular Ectasia

NIH Rare Diseases : 50 watermelon stomach is a condition in which the lining of the stomach bleeds, causing it to look like the characteristic stripes of a watermelon when viewed by endoscopy. although it can develop in men and women of all ages, watermelon stomach is most commonly observed in older women (over age 70 years). signs and symptoms of watermelon stomach include blood in the stool, hematemesis (vomiting blood) and anemia. the exact cause of watermelon stomach is unknown; however, it is often diagnosed in people with other chronic (long-term) conditions such as cirrhosis (scarring of the liver and poor liver function), autoimmune disease, systemic sclerosis, and crest syndrome. treatment consists of surgery and/or medications to stop or control the bleeding. last updated: 8/2/2016

MalaCards based summary : Gastric Antral Vascular Ectasia, also known as watermelon stomach, is related to transcobalamin ii deficiency and hyperlipidemia, familial combined. An important gene associated with Gastric Antral Vascular Ectasia is SST (Somatostatin), and among its related pathways/superpathways is Salivary secretion. The drugs Proton pump inhibitors and Iron have been mentioned in the context of this disorder. Affiliated tissues include liver, myeloid and kidney, and related phenotype is Increased Nanog expression.

Wikipedia : 71 Gastric antral vascular ectasia (GAVE) is an uncommon cause of chronic gastrointestinal bleeding or iron... more...

Related Diseases for Gastric Antral Vascular Ectasia

Diseases related to Gastric Antral Vascular Ectasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
id Related Disease Score Top Affiliating Genes
1 transcobalamin ii deficiency 10.8
2 hyperlipidemia, familial combined 10.7
3 spherocytosis, type 1 10.7
4 cartilage-hair hypoplasia 10.7
5 smith-lemli-opitz syndrome 10.7
6 agammaglobulinemia 1 10.7
7 marfan syndrome 10.7
8 campomelic dysplasia 10.7
9 ichthyosis, x-linked 10.7
10 ciliary dyskinesia, primary, 1, with or without situs inversus 10.7
11 progressive external ophthalmoplegia, autosomal recessive 1 10.7
12 von willebrand disease, platelet-type 10.7
13 caudal regression syndrome 10.7
14 portal hypertension 10.5
15 secondary syphilis 10.1 ATP4A SST
16 brain edema 10.1 ATP4A SST
17 angelucci's syndrome 10.1 ATP4A SST
18 erythromelalgia 10.1 ATP4A UBTF
19 hematopoietic stem cell transplantation 10.1
20 leukemia 10.1
21 liver disease 10.1
22 mucositis 10.1
23 angiodysplasia 10.1
24 chronic gonococcal salpingitis 10.0 ATP4A CTC1
25 scleral staphyloma 10.0 ATP4A SST
26 childhood malignant hemangiopericytoma 10.0 ATP4A SST
27 paracoccidioidomycosis 9.9 ATP4A BRD4
28 childhood intracortical osteosarcoma 9.9 ATP4A SST
29 capillary hemangioma 9.9
30 hemangioma 9.9
31 proctitis 9.9
32 bacteremia 9.9
33 liver cirrhosis 9.9
34 primary biliary cirrhosis 9.9
35 duodenitis 9.9
36 myeloid leukemia 9.9
37 protein-losing enteropathy 9.9
38 chronic graft versus host disease 9.9
39 iron deficiency anemia 9.9
40 radiation proctitis 9.9
41 deficiency anemia 9.9
42 lateral sinus thrombosis 9.9 ATP4A BRD4
43 cervical alveolar soft part sarcoma 9.8 BRD4 SST
44 dengue hemorrhagic fever 9.8
45 gastritis 9.8
46 uremia 9.8
47 stomach disease 9.8
48 peritonitis 9.8
49 crest syndrome 9.8
50 lupus erythematosus 9.8

Graphical network of the top 20 diseases related to Gastric Antral Vascular Ectasia:



Diseases related to Gastric Antral Vascular Ectasia

Symptoms & Phenotypes for Gastric Antral Vascular Ectasia

GenomeRNAi Phenotypes related to Gastric Antral Vascular Ectasia according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased Nanog expression GR00371-A-2 9.4 BRD4 UBTF
2 Increased Nanog expression GR00371-A-4 9.4 UBTF BRD4
3 Increased Nanog expression GR00371-A-5 9.4 UBTF BRD4

Drugs & Therapeutics for Gastric Antral Vascular Ectasia

Drugs for Gastric Antral Vascular Ectasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Proton pump inhibitors Phase 2, Phase 3
2
Iron Approved Phase 2 7439-89-6 23925
3 Angiogenesis Inhibitors Phase 2
4 Angiogenesis Modulating Agents Phase 2
5 Anti-Bacterial Agents Phase 2
6 Anti-Infective Agents Phase 2
7 Immunosuppressive Agents Phase 2
8
Carvedilol Approved, Investigational 72956-09-3 2585
9
Simvastatin Approved 79902-63-9 54454
10 Adrenergic Agents
11 Adrenergic alpha-1 Receptor Antagonists
12 Adrenergic alpha-Antagonists
13 Adrenergic Antagonists
14 Adrenergic beta-Antagonists
15 Anticholesteremic Agents
16 Antihypertensive Agents
17 Antimetabolites
18 Hydroxymethylglutaryl-CoA Reductase Inhibitors
19 Hypolipidemic Agents
20 Lipid Regulating Agents
21 Neurotransmitter Agents
22 Vasodilator Agents

Interventional clinical trials:


id Name Status NCT ID Phase
1 Endoscopic Band Ligation Versus Argon Plasma Coagulation for the Treatment of Gastric Antral Vascular Ectasia: a Randomized Clinical Trial Completed NCT01601639 Phase 3
2 Cyrotherapy vs. APC in GAVE Completed NCT00587405 Phase 2, Phase 3
3 Long-term Effects of Thalidomide for Recurrent Gastrointestinal Bleeding Due to Vascular Malformation Completed NCT00964496 Phase 2
4 To Compare the Efficacy and Safety of Carvedilol With or Without Simvastatin in Patients With Portal Hypertension and Esophageal Varices. Recruiting NCT02465645

Search NIH Clinical Center for Gastric Antral Vascular Ectasia

Cochrane evidence based reviews: gastric antral vascular ectasia

Genetic Tests for Gastric Antral Vascular Ectasia

Anatomical Context for Gastric Antral Vascular Ectasia

MalaCards organs/tissues related to Gastric Antral Vascular Ectasia:

39
Liver, Myeloid, Kidney

Publications for Gastric Antral Vascular Ectasia

Articles related to Gastric Antral Vascular Ectasia:

(show top 50) (show all 160)
id Title Authors Year
1
Vascular-targeted photodynamic therapy of gastric antral vascular ectasia (GAVE). ( 27871022 )
2017
2
Hemorrhage from Extra-Antral Gastric Antral Vascular Ectasia in a Patient with Duodenal Heterotopic Gastric Mucosa. ( 27830096 )
2016
3
Radiofrequency ablation of gastric antral vascular ectasia of the gastric cardia. ( 27669532 )
2016
4
Gastric antral vascular ectasia. ( 27728256 )
2016
5
Gastric Antral Vascular Ectasia during the Treatment of Chronic Myelogenous Leukemia with Imatinib Mesylate. ( 26726089 )
2016
6
Endoscopic band ligation for gastric antral vascular ectasia: time for a new indication? ( 26820079 )
2016
7
Clinical Characterization of Gastric Antral Vascular Ectasia: A Potential Manifestation of the Metabolic Syndrome. ( 27476085 )
2016
8
Refractory gastric antral vascular ectasia: a new endoscopic approach. ( 26592837 )
2015
9
Portal hypertensive gastropathy and gastric antral vascular ectasia. ( 26564121 )
2015
10
Patients with Gastric Antral Vascular Ectasia (GAVE) Are at a Higher Risk of Gastrointestinal Bleeding in the Absence of Cirrhosis. ( 26807380 )
2015
11
Erythropoietin resistance in end-stage renal disease patient with gastric antral vascular ectasia. ( 26154650 )
2015
12
Gastric antral vascular ectasia: a prospective study of treatment with endoscopic band ligation. ( 25650636 )
2015
13
Portal hypertensive gastropathy and gastric antral vascular ectasia. ( 26376475 )
2015
14
Endoscopic radiofrequency ablation for APC refractory gastric antral vascular ectasia using the HALO90 system in a kidney transplant candidate. ( 25952805 )
2015
15
Gastric Antral Vascular Ectasia (GAVE): An Overlooked Diagnosis. ( 25772970 )
2015
16
Gastric Antral Vascular Ectasia in Systemic Sclerosis: Current Concepts. ( 26633973 )
2015
17
Radiofrequency ablation therapy - the grave for GAVE (gastric antral vascular ectasia)? ( 26135653 )
2015
18
Transjugular intrahepatic portosystemic shunt as bridge-to-surgery in refractory gastric antral vascular ectasia. ( 25987803 )
2015
19
Development of hyperplastic polyps following argon plasma coagulation of gastric antral vascular ectasia. ( 26283860 )
2015
20
Intravenous cyclophosphamide as a therapeutic option for severe refractory gastric antral vascular ectasia in systemic sclerosis. ( 26429218 )
2015
21
Imatinib-induced gastric antral vascular ectasia in three patients with chronic myeloid leukaemia. ( 26134364 )
2015
22
Radiofrequency ablation for treatment of refractory gastric antral vascular ectasia (with video). ( 26135652 )
2015
23
Autologous hematopoietic stem cell transplant for systemic sclerosis improves anemia from gastric antral vascular ectasia. ( 25729047 )
2015
24
Dasatinib-induced gastric antral vascular ectasia in a patient with acute lymphoblastic leukaemia. ( 25855138 )
2015
25
Erythropoietin resistance in end-stage renal disease patient with gastric antral vascular ectasia. ( 26398652 )
2015
26
Bacteremia and sepsis after radiofrequency ablation of gastric antral vascular ectasia. ( 24721631 )
2014
27
Watermelon stomach: gastric antral vascular ectasia. ( 25475404 )
2014
28
Approach to the management of portal hypertensive gastropathy and gastric antral vascular ectasia. ( 25440929 )
2014
29
Review article: the management of portal hypertensive gastropathy and gastric antral vascular ectasia in cirrhosis. ( 24889902 )
2014
30
Refractory gastric antral vascular ectasia treated by a novel through-the-scope ablation catheter. ( 24731266 )
2014
31
Microvascular architecture in a case of gastric antral vascular ectasia (watermelon stomach). ( 24594964 )
2014
32
Radiofrequency Ablation of Treatment-refractory Gastric Antral Vascular Ectasia (GAVE). ( 24743681 )
2014
33
Prevalence, Correlates and Outcomes of Gastric Antral Vascular Ectasia in Systemic Sclerosis: A EUSTAR Case-control Study. ( 24293584 )
2014
34
Treatment resistant gastric antral vascular ectasia in a patient undergoing haemodialysis. ( 24965484 )
2014
35
Gastrointestinal: radiofrequency ablation in the management of refractory gastric antral vascular ectasia. ( 24750200 )
2014
36
Imatinib-induced gastric antral vascular ectasia in a patient with chronic myeloid leukemia. ( 25356253 )
2014
37
Gastric antral vascular ectasia unresponsive to endoscopic treatment requiring antrectomy. ( 25240797 )
2014
38
Gastric antral vascular ectasia: a rare manifestation for gastrointestinal bleeding in left ventricular assist device patients-an initial report. ( 24821465 )
2014
39
Successful treatment of refractory gastric antral vascular ectasia by distal gastrectomy: A case report. ( 25320549 )
2014
40
Gastric antral vascular ectasia: the evolution of therapeutic modalities. ( 26135263 )
2014
41
Gastric Antral Vascular Ectasia. ( 26259325 )
2014
42
Radiofrequency ablation for the treatment of gastric antral vascular ectasia. ( 25111135 )
2014
43
Diagnosis and management of gastric antral vascular ectasia. ( 23330048 )
2013
44
Medical and Endoscopic Therapies for Angiodysplasia and Gastric Antral Vascular Ectasia: A Systematic Review. ( 24013107 )
2013
45
Gastric antral vascular ectasia (GAVE) in two non-cirrhotic patients involved large area of stomach: case report and literature review. ( 24478930 )
2013
46
Post-transplant gastric antral vascular ectasia after intra-venous busulfan regimen. ( 23632949 )
2013
47
Gastric antral vascular ectasia and its clinical correlates in patients with early diffuse systemic sclerosis in the SCOT trial. ( 23418384 )
2013
48
Radiofrequency ablation for refractory gastric antral vascular ectasia (with video). ( 23660565 )
2013
49
Gastric antral vascular ectasia: case report and review of the literature. ( 23262190 )
2013
50
Band ligation of gastric antral vascular ectasia is a safe and effective endoscopic treatment. ( 23808945 )
2013

Variations for Gastric Antral Vascular Ectasia

Expression for Gastric Antral Vascular Ectasia

Search GEO for disease gene expression data for Gastric Antral Vascular Ectasia.

Pathways for Gastric Antral Vascular Ectasia

Pathways related to Gastric Antral Vascular Ectasia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
10.84 ATP4A SST

GO Terms for Gastric Antral Vascular Ectasia

Biological processes related to Gastric Antral Vascular Ectasia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 response to nutrient GO:0007584 8.62 OXCT1 SST

Sources for Gastric Antral Vascular Ectasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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