GAVE
MCID: GST020
MIFTS: 36

Gastric Antral Vascular Ectasia (GAVE) malady

Gastrointestinal, Cardiovascular categories

Summaries for Gastric Antral Vascular Ectasia

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Watermelon stomach is a condition in which the lining of the stomach bleeds, causing it to look like the characteristic stripes of a watermelon when viewed by endoscopy. symptoms of watermelon stomach may include sudden, unexplained bleeding, chronic bleeding, and anemia. other symptoms may include vomiting of blood and dark stools that contain blood.click here to view a diagram of the stomach. last updated: 11/7/2011

MalaCards: Gastric Antral Vascular Ectasia, also known as watermelon stomach, is related to gastric outlet obstruction and portal hypertension. An important gene associated with Gastric Antral Vascular Ectasia is SST (somatostatin), and among its related pathways are Gastric acid secretion and Ion channel transport. The compounds bromocriptine and octreotide have been mentioned in the context of this disorder. Affiliated tissues include small intestine and liver, and related mouse phenotype homeostasis/metabolism.

Wikipedia:64 Gastric antral vascular ectasia (GAVE) is an uncommon cause of chronic gastrointestinal bleeding or iron... more...

Aliases & Classifications for Gastric Antral Vascular Ectasia

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 57SNOMED-CT, 61UMLS, 35MeSH, 40NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal, Cardiovascular


Aliases & Descriptions:

gastric antral vascular ectasia 8 43 10
watermelon stomach 8 43
gave 43


External Ids:

Disease Ontology8 DOID:2493
MeSH35 D020252
SNOMED-CT57 43935004, 412795008
NCIt40 C84724

Related Diseases for Gastric Antral Vascular Ectasia

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Gastric Antral Vascular Ectasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 58)
idRelated DiseaseScoreTop Affiliating Genes
1gastric outlet obstruction30.5ATP12A, ATP4A
2portal hypertension10.7
3vascular disease10.7
4angiodysplasia10.5
5deficiency anemia10.4
6graft versus host disease10.4
7gastric hemangioma10.4
8proctitis10.4
9primary biliary cirrhosis10.4
10gastric ulcer10.4
11iron deficiency anemia10.4
12protein-losing enteropathy10.4
13chronic graft versus host disease10.4
14cutaneous sclerosis10.4
15image syndrome10.4
16radiation proctitis10.4
17hematopoietic stem cell transplantation10.4
18dengue hemorrhagic fever10.2
19systemic lupus erythematosus10.2
20stomach disease10.2
21uremia10.2
22hemorrhagic fever10.2
23generalized essential telangiectasia10.2
24transcobalamin ii deficiency10.1
25glucagonoma10.0SST
26dyskinesia of esophagus10.0ATP12A, ATP4A
27dyspepsia10.0ATP4A, ATP12A
28osteopetrosis10.0ATP12A, ATP4A
29irritable bowel syndrome10.0ATP4A, ATP12A
30bile reflux10.0ATP4A, ATP12A
31hiatus hernia10.0ATP12A, ATP4A
32duodenitis10.0ATP4A, ATP12A
33achalasia10.0ATP12A, ATP4A
34gastroesophageal reflux disease10.0ATP4A, ATP12A
35esophagitis10.0ATP4A, ATP12A
36paraganglioma10.0SST
37esophageal cancer10.0ATP12A, ATP4A
38congenital heart defect10.0ATP4A, ATP12A
39proliferative diabetic retinopathy10.0SST
40gastrinoma10.0SST, ATP4A, ATP12A
41peptic ulcer10.0SST, ATP4A, ATP12A
42diarrhea10.0SST, ATP4A, ATP12A
43gastritis10.0ATP12A, ATP4A, SST
44smith-lemli-opitz syndrome10.0
45marfan syndrome10.0
46x-linked ichthyosis10.0
47cartilage-hair hypoplasia10.0
48congenital hypothyroidism10.0
49hereditary spherocytosis10.0
50sick sinus syndrome10.0

Graphical network of the top 20 diseases related to Gastric Antral Vascular Ectasia:



Diseases related to gastric antral vascular ectasia

Clinical Features for Gastric Antral Vascular Ectasia

Drugs & Therapeutics for Gastric Antral Vascular Ectasia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Gastric Antral Vascular Ectasia

Search CenterWatch for Gastric Antral Vascular Ectasia

Genetic Tests for Gastric Antral Vascular Ectasia

Anatomical Context for Gastric Antral Vascular Ectasia

Sources:
33MalaCards
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MalaCards organs/tissues related to Gastric Antral Vascular Ectasia:

33
Small intestine, Liver

Animal Models for Gastric Antral Vascular Ectasia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Gastric Antral Vascular Ectasia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.6ELOVL2, EPO, SST, ATP4A, ATP12A

Publications for Gastric Antral Vascular Ectasia

Sources:
51PubMed
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Articles related to Gastric Antral Vascular Ectasia:

(show top 50)    (show all 118)
idTitleAuthorsYear
1
Prevalence, Correlates and Outcomes of Gastric Antral Vascular Ectasia in Systemic Sclerosis: A EUSTAR Case-control Study. (24293584)
2014
2
Diagnosis and management of gastric antral vascular ectasia. (23330048)
2013
3
Massive gastric antral vascular ectasia successfully treated by endoscopic band ligation as the initial therapy. (23515642)
2013
4
Gastric antral vascular ectasia: case report and review of the literature. (23262190)
2013
5
Radiofrequency ablation for refractory gastric antral vascular ectasia (with video). (23660565)
2013
6
Band ligation of gastric antral vascular ectasia is a safe and effective endoscopic treatment. (23808945)
2013
7
Post-transplant gastric antral vascular ectasia after intra-venous busulfan regimen. (23632949)
2013
8
Medical and Endoscopic Therapies for Angiodysplasia and Gastric Antral Vascular Ectasia: A Systematic Review. (24013107)
2013
9
Endoscopic band ligation versus argon plasma coagulation for gastric antral vascular ectasia associated with liver diseases. (22725108)
2012
10
Comparison of argon plasma coagulation in management of upper gastrointestinal angiodysplasia and gastric antral vascular ectasia hemorrhage. (22681987)
2012
11
The management of portal hypertensive gastropathy and gastric antral vascular ectasia. (21095166)
2011
12
Gastric antral vascular ectasia in systemic sclerosis. (22121374)
2011
13
Gastric antral vascular ectasia unmasked by alprostadil for digital ulceration in scleroderma. (21459962)
2011
14
Computed virtual chromoendoscopy - enhanced videocapsule endoscopy is of potential benefit in gastric antral vascular ectasia syndrome refractory to endoscopic treatment. (21961101)
2011
15
Clinical images: Gastric antral vascular ectasia in systemic sclerosis. (20039398)
2010
16
A novel endoscopic ablation of gastric antral vascular ectasia. (21160630)
2010
17
Anti-RNA polymerase III antibodies as a risk marker for early gastric antral vascular ectasia (GAVE) in systemic sclerosis. (20595295)
2010
18
CD61, CD31, and CD34 improve diagnostic accuracy in gastric antral vascular ectasia and portal hypertensive gastropathy: An immunohistochemical and digital morphometric study. (20351488)
2010
19
Improvement of severe systemic sclerosis-associated gastric antral vascular ectasia following immunosuppressive treatment with intravenous cyclophosphamide. (19605670)
2009
20
Argon photocoagulation in the treatment of gastric antral vascular ectasia and radiation proctitis. (20011731)
2009
21
Snare coagulation for gastric antral vascular ectasia ablation. (19410054)
2009
22
Gastric antral vascular ectasia (GAVE) associated with systemic sclerosis. (18612935)
2008
23
Gastric antral vascular ectasia--an unusual cause of gastric outlet obstruction: report of a case. (17522771)
2007
24
Efficacy of argon plasma coagulation for gastric antral vascular ectasia associated with chronic liver disease. (15967712)
2005
25
Gastric antral vascular ectasia in 2-yr-old girl undergoing unrelated cord blood stem cell transplantation. (16269052)
2005
26
Review article: current therapeutic options for gastric antral vascular ectasia. (12869075)
2003
27
Clinical features and treatment of hematopoietic stem cell transplantation-associated gastric antral vascular ectasia. (12900779)
2003
28
Gastric antral vascular ectasia (watermelon stomach) in a patient with SjAPgren's syndrome. (12734912)
2003
29
Gastric antral vascular ectasia in systemic sclerosis: complete resolution with methylprednisolone and cyclophosphamide. (11454645)
2001
30
Clinical comparisons between two subsets of gastric antral vascular ectasia. (11375585)
2001
31
Gastric antral vascular ectasia and its relation with portal hypertension. (10733318)
2000
32
Endoscopic YAG laser treatment of watermelon stomach (gastric antral vascular ectasia) in patients with systemic sclerosis. (11072602)
2000
33
Treatment of chronic bleeding from gastric antral vascular ectasia (GAVE) with estrogen-progesterone in cirrhotic patients: an open pilot study. (10520843)
1999
34
Gastric antral vascular ectasia in cirrhotic patients: absence of relation with portal hypertension. (10205216)
1999
35
Disappearance of gastric antral vascular ectasia after percutaneous transhepatic obliteration. (10228788)
1999
36
Tranexamic acid for severe bleeding gastric antral vascular ectasia in cirrhosis. (9659175)
1998
37
Gastric antral vascular ectasia with portal hypertension: treatment with TIPSS. (9399773)
1997
38
Bleeding from gastric antral vascular ectasia in marrow transplant patients. (8885337)
1996
39
Gastric antral vascular ectasia (watermelon stomach) in patients with systemic sclerosis. (8849390)
1996
40
Gastric antral vascular ectasia causing severe anemia. (8887039)
1996
41
Clinical and histological features of gastric antral vascular ectasia: successful treatment with endoscopic laser therapy. (8742925)
1996
42
A case of gastric antral vascular ectasia--increase of neuroendocrine cells in the antrum. (7647906)
1995
43
Antral motility in patients with cirrhosis with or without gastric antral vascular ectasia. (7489933)
1995
44
Endoscopic laser treatment of diffuse gastric antral vascular ectasia. (8174981)
1994
45
Successful treatment of two patients with gastric antral vascular ectasia 'watermelon stomach' using endoscopic Nd-YAG laser therapy. (1953533)
1991
46
Gastric antral vascular ectasia associated with gastric carcinoma. (2039004)
1991
47
Endoscopic biopsy is diagnostic in gastric antral vascular ectasia. The "watermelon stomach". (2721320)
1989
48
Neuroendocrine cell proliferations in gastric antral vascular ectasia. (2785944)
1989
49
Gastric antral vascular ectasia and primary biliary cirrhosis. (3265915)
1988
50
Diffuse gastric antral vascular ectasia: cause of chronic gastrointestinal blood loss. (3500039)
1987

Genetic Variations for Gastric Antral Vascular Ectasia

Expression for genes affiliated with Gastric Antral Vascular Ectasia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Gastric Antral Vascular Ectasia

Search GEO for disease gene expression data for Gastric Antral Vascular Ectasia.

Pathways for genes affiliated with Gastric Antral Vascular Ectasia

Sources:
30KEGG, 54Reactome
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Pathways related to Gastric Antral Vascular Ectasia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4SST, ATP4A
2
Hide members
9.0ATP4A, ATP12A

Compounds for genes affiliated with Gastric Antral Vascular Ectasia

Sources:
29IUPHAR, 45Novoseek, 11DrugBank, 60Tocris Bioscience, 50PharmGKB, 2BitterDB, 24HMDB
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Compounds related to Gastric Antral Vascular Ectasia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1bromocriptine29 45 1111.7SST, EPO
2octreotide45 60 29 1112.6EPO, SST
3caffeine45 50 29 2 11 2414.6EPO, SST
4omeprazole45 29 50 11 2413.6SST, ATP4A
5carboplatin45 50 1111.5EPO, SST
6ouabain45 1110.3EPO, ATP12A
7hydrocortisone45 2 60 1112.3EPO, SST
8pantoprazole45 50 11 2411.8SST, ATP4A, ATP12A

GO Terms for genes affiliated with Gastric Antral Vascular Ectasia

Sources:
16Gene Ontology
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Biological processes related to Gastric Antral Vascular Ectasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ion transmembrane transportGO:0342209.0ATP4A, ATP12A
2ATP biosynthetic processGO:0067548.7ATP4A, ATP12A

Molecular functions related to Gastric Antral Vascular Ectasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.6EPO, SST
2hydrogen:potassium-exchanging ATPase activityGO:0089008.7ATP4A, ATP12A

Products for genes affiliated with Gastric Antral Vascular Ectasia

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  • Proteins
  • Lysates
  • Antibodies

Sources for Gastric Antral Vascular Ectasia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet