GAVE
MCID: GST020
MIFTS: 38

Gastric Antral Vascular Ectasia (GAVE) malady

Gastrointestinal diseases, Cardiovascular diseases categories

Summaries for Gastric Antral Vascular Ectasia

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Sources:
42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Watermelon stomach is a condition in which the lining of the stomach bleeds, causing it to look like the characteristic stripes of a watermelon when viewed by endoscopy. symptoms of watermelon stomach may include sudden, unexplained bleeding, chronic bleeding, and anemia. other symptoms may include vomiting of blood and dark stools that contain blood.click here to view a diagram of the stomach. last updated: 11/7/2011

MalaCards: Gastric Antral Vascular Ectasia, also known as watermelon stomach, is related to gastritis and portal hypertension. An important gene associated with Gastric Antral Vascular Ectasia is SST (somatostatin), and among its related pathways are Gastric acid secretion and Ion channel transport. The compounds bromocriptine and octreotide have been mentioned in the context of this disorder. Affiliated tissues include liver, and related mouse phenotype homeostasis/metabolism.

Wikipedia:63 Gastric antral vascular ectasia (GAVE) is an uncommon cause of chronic gastrointestinal bleeding or iron... more...

Aliases & Classifications for Gastric Antral Vascular Ectasia

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 56SNOMED-CT, 60UMLS, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Cardiovascular diseases


Aliases & Descriptions:

gastric antral vascular ectasia 8 42 10
watermelon stomach 8 42
gave 42


External Ids:

Disease Ontology8 DOID:2493
MeSH34 D020252
SNOMED-CT56 43935004, 412795008
NCIt39 C84724

Related Diseases for Gastric Antral Vascular Ectasia

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Gastric Antral Vascular Ectasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
1gastritis30.2ATP4A, ATP12A, SST
2portal hypertension10.8
3hypertension10.8
4vascular disease10.6
5angiodysplasia10.5
6liver disease10.5
7deficiency anemia10.3
8graft versus host disease10.3
9gastric hemangioma10.3
10proctitis10.3
11primary biliary cirrhosis10.3
12gastric ulcer10.3
13iron deficiency anemia10.3
14protein-losing enteropathy10.3
15capillary hemangioma10.3
16hemangioma10.3
17liver cirrhosis10.3
18scleroderma10.3
19image syndrome10.3
20dengue hemorrhagic fever10.2
21systemic lupus erythematosus10.2
22lupus erythematosus10.2
23peritonitis10.2
24stomach disease10.2
25uremia10.2
26transcobalamin ii deficiency10.1
27glucagonoma10.0SST
28dyskinesia of esophagus10.0ATP12A, ATP4A
29dyspepsia10.0ATP12A, ATP4A
30osteopetrosis10.0ATP4A, ATP12A
31gastric outlet obstruction10.0ATP4A, ATP12A
32irritable bowel syndrome10.0ATP4A, ATP12A
33bile reflux10.0ATP12A, ATP4A
34hiatus hernia10.0ATP12A, ATP4A
35duodenitis10.0ATP4A, ATP12A
36achalasia10.0ATP12A, ATP4A
37gastroesophageal reflux disease10.0ATP12A, ATP4A
38esophagitis10.0ATP4A, ATP12A
39paraganglioma10.0SST
40esophageal cancer10.0ATP4A, ATP12A
41congenital heart defect10.0ATP4A, ATP12A
42proliferative diabetic retinopathy10.0SST
43gastrinoma10.0SST, ATP4A, ATP12A
44peptic ulcer10.0ATP12A, ATP4A, SST
45diarrhea10.0ATP4A, ATP12A, SST
46smith-lemli-opitz syndrome9.9
47marfan syndrome9.9
48x-linked ichthyosis9.9
49cartilage-hair hypoplasia9.9
50congenital hypothyroidism9.9

Graphical network of the top 20 diseases related to Gastric Antral Vascular Ectasia:



Diseases related to gastric antral vascular ectasia

Clinical Features for Gastric Antral Vascular Ectasia

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Drugs & Therapeutics for Gastric Antral Vascular Ectasia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Gastric Antral Vascular Ectasia

Search CenterWatch for Gastric Antral Vascular Ectasia

Genetic Tests for Gastric Antral Vascular Ectasia

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Anatomical Context for Gastric Antral Vascular Ectasia

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32MalaCards
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MalaCards organs/tissues related to Gastric Antral Vascular Ectasia:

32
Liver

Animal Models for Gastric Antral Vascular Ectasia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Gastric Antral Vascular Ectasia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.6ELOVL2, EPO, SST, ATP4A, ATP12A

Publications for Gastric Antral Vascular Ectasia

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50PubMed
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Articles related to Gastric Antral Vascular Ectasia:

(show top 50)    (show all 118)
idTitleAuthorsYear
1
Prevalence, Correlates and Outcomes of Gastric Antral Vascular Ectasia in Systemic Sclerosis: A EUSTAR Case-control Study. (24293584)
2014
2
Diagnosis and management of gastric antral vascular ectasia. (23330048)
2013
3
Massive gastric antral vascular ectasia successfully treated by endoscopic band ligation as the initial therapy. (23515642)
2013
4
Gastric antral vascular ectasia: case report and review of the literature. (23262190)
2013
5
Radiofrequency ablation for refractory gastric antral vascular ectasia (with video). (23660565)
2013
6
Band ligation of gastric antral vascular ectasia is a safe and effective endoscopic treatment. (23808945)
2013
7
Detection of active bleeding from gastric antral vascular ectasia by capsule endoscopy. (23515703)
2013
8
Simultaneous occurrence of gastric antral vascular ectasia and protein-losing enteropathy in chronic graft-versus-host disease. (23378184)
2013
9
Capillary hemangioma of the esophagus in a patient with systemic sclerosis and gastric antral vascular ectasia. (22817793)
2012
10
The management of portal hypertensive gastropathy and gastric antral vascular ectasia. (21095166)
2011
11
Long-term effect of argon plasma coagulation (APC) in the treatment of gastric antral vascular ectasia (GAVE). (21429455)
2011
12
Gastric antral vascular ectasia unmasked by alprostadil for digital ulceration in scleroderma. (21459962)
2011
13
Clinical images: Gastric antral vascular ectasia in systemic sclerosis. (20039398)
2010
14
Anti-RNA polymerase III antibodies as a risk marker for early gastric antral vascular ectasia (GAVE) in systemic sclerosis. (20595295)
2010
15
An unusual cause of upper GI bleeding: gastric antral vascular ectasia. (21090029)
2010
16
CD61, CD31, and CD34 improve diagnostic accuracy in gastric antral vascular ectasia and portal hypertensive gastropathy: An immunohistochemical and digital morphometric study. (20351488)
2010
17
Gastric antral vascular ectasia in systemic sclerosis: demographics and disease predictors. (20080908)
2010
18
Endoscopic argon plasma coagulation for the treatment of gastric antral vascular ectasia-related bleeding in patients with liver cirrhosis. (19329853)
2009
19
Gastric antral vascular ectasia (watermelon stomach)-an enigmatic and often-overlooked cause of gastrointestinal bleeding in the elderly. (20740102)
2009
20
Snare coagulation for gastric antral vascular ectasia ablation. (19410054)
2009
21
Gastric antral vascular ectasia (GAVE) associated with systemic sclerosis. (18612935)
2008
22
Treatment of gastric antral vascular ectasia (watermelon stomach) with endoscopic band ligation. (18533150)
2008
23
Gastric antral vascular ectasia successfully controlled by argon plasma coagulation. (17767344)
2007
24
Treatment of gastropathy and gastric antral vascular ectasia in patients with portal hypertension. (18221609)
2007
25
Efficacy of neodymium:YAG laser therapy for gastric antral vascular ectasia (GAVE) following hematopoietic cell transplant. (16284614)
2006
26
Treatment of chronic transfusion-dependent gastric antral vascular ectasia (watermelon stomach) with thalidomide. (16538122)
2006
27
Gastric antral vascular ectasia (watermelon stomach) in patients with ESRD. (16731286)
2006
28
Does capsule endoscopy recognise gastric antral vascular ectasia more frequently than conventional endoscopy? (17205150)
2006
29
Efficacy of argon plasma coagulation for gastric antral vascular ectasia associated with chronic liver disease. (15967712)
2005
30
Gastric antral vascular ectasia in 2-yr-old girl undergoing unrelated cord blood stem cell transplantation. (16269052)
2005
31
Gastric antral vascular ectasia (GAVE) syndrome. (15839460)
2004
32
Review article: current therapeutic options for gastric antral vascular ectasia. (12869075)
2003
33
Gastric antral vascular ectasia (watermelon stomach) in a patient with SjAPgren's syndrome. (12734912)
2003
34
Cure of gastric antral vascular ectasia by liver transplantation despite persistent portal hypertension: a clue for pathogenesis. (12149766)
2002
35
Gastric antral vascular ectasia in systemic sclerosis: complete resolution with methylprednisolone and cyclophosphamide. (11454645)
2001
36
Gastric antral vascular ectasia in cirrhotic patients: absence of relation with portal hypertension. (10205216)
1999
37
Disappearance of gastric antral vascular ectasia after percutaneous transhepatic obliteration. (10228788)
1999
38
Histopathologic changes are not specific for diagnosis of gastric antral vascular ectasia (GAVE) syndrome: a review of the pathogenesis and a comparative image analysis morphometric study of GAVE syndrome and gastric hyperplastic polyps. (9576573)
1998
39
More on gastric antral vascular ectasia (watermelon stomach) in uremic patients. (8914187)
1996
40
Clinical and histological features of gastric antral vascular ectasia: successful treatment with endoscopic laser therapy. (8742925)
1996
41
A case of gastric antral vascular ectasia--increase of neuroendocrine cells in the antrum. (7647906)
1995
42
Gastric antral vascular ectasia: a case report of a 10 year follow-up with special consideration of histopathological aspects. (8197812)
1994
43
Endoscopic laser treatment of diffuse gastric antral vascular ectasia. (8174981)
1994
44
Endoscopic laser therapy in a case of gastric antral vascular ectasia (watermelon stomach). (8322479)
1993
45
Two cases of gastric antral vascular ectasia--response to medical treatment. (1765249)
1991
46
Successful treatment of two patients with gastric antral vascular ectasia 'watermelon stomach' using endoscopic Nd-YAG laser therapy. (1953533)
1991
47
Gastric antral vascular ectasia associated with gastric carcinoma. (2039004)
1991
48
Gastric antral vascular ectasia (watermelon stomach)--therapeutic options. (2235802)
1990
49
Endoscopic biopsy is diagnostic in gastric antral vascular ectasia. The "watermelon stomach". (2721320)
1989
50
Gastric antral vascular ectasia: the watermelon stomach. (6332757)
1984

Genetic Variations for Gastric Antral Vascular Ectasia

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Expression for genes affiliated with Gastric Antral Vascular Ectasia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gastric Antral Vascular Ectasia

Search GEO for disease gene expression data for Gastric Antral Vascular Ectasia.

Pathways for genes affiliated with Gastric Antral Vascular Ectasia

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29KEGG, 53Reactome
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Pathways related to Gastric Antral Vascular Ectasia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4SST, ATP4A
2
Hide members
9.0ATP4A, ATP12A

Compounds for genes affiliated with Gastric Antral Vascular Ectasia

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Sources:
28IUPHAR, 44Novoseek, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 2BitterDB, 24HMDB
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Compounds related to Gastric Antral Vascular Ectasia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1bromocriptine28 44 1111.7SST, EPO
2octreotide44 59 28 1112.6EPO, SST
3caffeine44 49 28 2 11 2414.6EPO, SST
4omeprazole44 28 49 11 2413.6SST, ATP4A
5carboplatin44 49 1111.5EPO, SST
6ouabain44 1110.3EPO, ATP12A
7hydrocortisone44 2 59 1112.3EPO, SST
8pantoprazole44 49 11 2411.8SST, ATP4A, ATP12A

GO Terms for genes affiliated with Gastric Antral Vascular Ectasia

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16Gene Ontology
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Biological processes related to Gastric Antral Vascular Ectasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ion transmembrane transportGO:0342209.0ATP4A, ATP12A
2ATP biosynthetic processGO:0067548.7ATP4A, ATP12A

Molecular functions related to Gastric Antral Vascular Ectasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.6EPO, SST
2hydrogen:potassium-exchanging ATPase activityGO:0089008.7ATP4A, ATP12A

Products for genes affiliated with Gastric Antral Vascular Ectasia

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Sources for Gastric Antral Vascular Ectasia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet