Gastric Cancer malady

Wikipedia: Stomach cancer, or gastric cancer, refers to cancer arising from any part of the stomach. Stomach cancer...⁴⁴ more...

MalaCards: Gastric Cancer, also known as malignant neoplasm of stomach, is related to carcinoma and prostatitis. An important gene associated with Gastric Cancer is CAPN9 (calpain 9), and among its related pathways are Rho Family GTPases and MAPK Signaling. The compounds serine and estrogen have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and liver, and related mouse phenotypes are homeostasis/metabolism and cellular.

OMIM: 137215

gastric cancer 7 33 32 malignant neoplasm of stomach 43

Diseases related to gastric cancer by text searches and GeneDecks gene sharing:

(show top 50)    (show all 867)

id	Related Disease	Score	Top Affiliating Genes
1	carcinoma	261.7	ZNF148, PIK3CB, PIK3CA, PIK3R1, PIAS1, PIK3CG
2	prostatitis	212.3	PIK3CB, PIK3CA, PIK3R1, PIAS1, PIK3CG, PIN1
3	adenocarcinoma	198.6	ZNF148, PIK3CB, PIK3CA, PIK3R1, PIK3CG, PIN1
4	pancreatitis	197.2	ZNF148, PIK3CB, PIK3CA, PIK3R1, PIK3CG, PIN1
5	leukemia	193.6	PIK3CB, PIK3CA, PIK3R1, PIAS1, PIK3CG, PIN1
6	hepatocellular carcinoma	175.5	ZNF148, PIK3CB, PIK3CA, PIK3R1, PIK3CG, PIN1
7	esophagitis	170.3	PIK3CB, PIK3CA, PIK3CG, PIN1, PIM1, LRP1B
8	melanoma	167.5	PIK3CB, PIK3CA, PIK3R1, PIK3CG, PIM1, KLF5
9	colon cancer	161.6	PIK3CB, PIK3CA, PIK3R1, PIAS1, PIK3CG, KLF4
10	thyroiditis	153.1	PIK3CB, PIK3CA, PIK3R1, PIK3CG, PIN1, LRP1B
11	breast carcinoma	148.3	PIK3CA, PIK3R1, PIK3CG, NDC80, NCOA3, RECK
12	cervicitis	146.9	PIK3CA, PIP5KL1, PIK3CG, PIN1, RFC1, PDCD4
13	hypoxia	132.6	PIK3CB, PIK3CA, PIK3R1, PIP5KL1, PIK3CG, PIM1
14	adenoma	129.4	PIK3CA, KLF4, NCOA3, PDCD4, RECK, REG1A
15	fibrosis	113.4	PIK3CA, PIK3CG, PIN1, KLF6, NCOA3, RECK
16	neuronitis	111.7	ZNF148, PIK3CB, PIK3CA, PIK3R1, PIK3CG, PIN1
17	esophageal squamous cell carcinoma	107.9	PIK3CA, PIN1, PIM1, LRP1B, NCOA3, RECK
18	peritonitis	93.9	REG1A, REG4, RELA, KIT, VWF, VTN
19	esophageal cancer	92.4	PIK3CB, PIK3CA, PIK3CG, KLF4, KLF5, PDCD4
20	retinoblastoma	81.6	PIK3CB, PIK3CA, PIK3R1, PIK3CG, KLF6, NDC80
21	neuroblastoma	76.3	PIK3CB, PIK3CA, PIK3R1, PIK3CG, PIN1, KLF4
22	arthritis	75.9	PIK3CG, PIN1, KLF12, KLF5, RFC1, RECK
23	sarcoma	75.7	PIK3CB, PIK3CA, PIK3R1, PIK3CG, NCOA3, RECK
24	polyposis	75.4	PIK3CG, PIN1, KLF4, KLF6, RELA, KIF2C
25	ovarian carcinoma	75.2	PIK3CA, PIP5KL1, PIK3CG, NCOA3, PDCD4, RECK
26	gonococcal synovitis	73.9	PIK3CB, PIK3CA, PIK3R1, PIK3CG, KLF4, RECK
27	myeloid leukemia	73.2	PIK3CB, PIK3CA, PIK3R1, PIK3CG, PIN1, PIM1
28	cervical cancer	72.4	PIK3CA, PIP5KL1, PIK3CG, PIN1, RFC1, RELA
29	rheumatoid arthritis	71.3	PIK3CG, PIN1, KLF12, KLF5, RFC1, RECK
30	lung carcinoma	70.8	PIK3CA, PIK3CG, KLF4, RELA, KIT, VWF
31	colon carcinoma	70.7	PIK3CB, PIK3CA, PIK3R1, PIAS1, PIK3CG, KLF4
32	anemia	70.6	PIM1, RELA, KIT, VWF, PCNA, RB1
33	liver cancer	68.7	PIK3CG, PIN1, REG1A, RELN, KIAA1524, SFRP2
34	myeloma	68.2	PIK3CA, PIK3R1, PIK3CG, RECK, RELA, KIT
35	alzheimer's disease	67.8	PIK3CB, PIK3CA, PIK3R1, PIP5KL1, PIK3CG, PIN1
36	gastritis	67.0	KIT, PCNA, SELE, SERPINA1, VEGFA, VCAM1
37	lung adenocarcinoma	64.7	PIK3CA, PIK3CG, KLF6, RCVRN, RB1, SETD2
38	lymphocytic leukemia	62.2	PIK3CA, PIK3CG, RECK, RELA, REV3L, KIT
39	duodenitis	61.9	PIK3CG, KIT, PCNA, GCG, BRAF, RARB
40	stomach carcinoma	61.8	KLF6, REV3L, KISS1, PCNA, BUB1, RB1
41	oral squamous cell carcinoma	61.7	PIK3CA, PIN1, PIM1, LRP1B, PDCD4, RECK
42	herpes simplex	61.5	PIK3CA, PIK3CG, RECK, REV3L, PCNA, SERPINE1
43	cholesterol	61.3	ZNF664, PIK3CB, PIK3CA, PIK3R1, PIAS1, PIK3CG
44	ataxia	60.6	PIK3CA, PIK3R1, PIK3CG, PIN1, VWF, RCVRN
45	cerebritis	60.3	PIK3R1, PIK3CG, KLF4, KLF6, REG1A, RELA
46	osteosarcoma	60.1	PIK3CB, PIK3CA, PIK3CG, RFC1, RECK, RELA
47	astrocytoma	60.1	PIK3CA, PIK3R1, PIK3CG, KLF6, RECK, RELA
48	atherosclerosis	58.9	PIK3CG, KLF4, KLF5, RECK, REG1A, RETN
49	retinitis	58.8	PIK3CA, PIK3CG, PIM1, KLF6, REV3L, KIT
50	endometrial cancer	58.8	PIK3CB, PIK3CA, PIK3R1, PIK3CG, NDC80, NCOA3

Clinical features from OMIM: 137215

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to gastric cancer:

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MGI Mouse Phenotypes related to gastric cancer:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism phenotype	MP:0005376	85.9	ZNF148, PIK3CB, PIK3CA, PIK3R1, PIK3CG, KLF4
2	cellular phenotype	MP:0005384	85.9	ZNF148, PIK3CB, PIK3CA, PIK3R1, PIK3CG, PIN1
3	growth/size phenotype	MP:0005378	71.2	ZNF148, PIK3CB, PIK3CA, PIK3R1, PIAS1, PIK3CG
4	nervous system phenotype	MP:0003631	54.0	ZNF148, LRRC3B, RECK, RELA, RELN, REV3L
5	tumorigenesis	MP:0002006	50.9	PIK3CB, PIK3CA, PIK3R1, PINX1, KLF4, NCOA3
6	digestive/alimentary phenotype	MP:0005381	46.5	ZNF148, KLF4, KLF5, NCOA3, RELN, RETNLB
7	behavior/neurological phenotype	MP:0005386	46.2	PIK3CA, KLF4, NCOA3, RELN, KIT, KISS1R
8	hematopoietic system phenotype	MP:0005397	44.5	PINX1, PIM1, KLF6, REV3L, KIT, KISS1R
9	normal phenotype	MP:0002873	44.4	ZNF148, PIK3R1, LRP1B, KLF4, KLF5, PDCD6
10	integument phenotype	MP:0010771	43.5	ZNF148, PIK3CG, PIN1, PINX1, KLF4, KLF6
11	muscle phenotype	MP:0005369	43.3	PIK3CA, PIK3R1, PIK3CG, KLF5, NCOA3, RELA
12	reproductive system phenotype	MP:0005389	42.8	ZNF148, PIK3CA, KLF4, KLF6, NCOA3, PDCD4
13	embryogenesis phenotype	MP:0005380	42.6	ZNF148, PIK3CB, PIK3CA, PINX1, KLF5, KLF6
14	skeleton phenotype	MP:0005390	38.6	PIK3CG, RECK, RELA, KIT, SFRP1, BUB1B
15	vision/eye phenotype	MP:0005391	37.9	PIK3CA, PIN1, RELA, RELN, KIT, RCVRN
16	renal/urinary system phenotype	MP:0005367	31.1	NCOA3, PDCD4, KIT, KISS1, KISS1R, RBPJ
17	no phenotypic analysis	MP:0003012	28.5	PIK3R1, SFRP1, SFRP2, PCNA, BUB1, RB1
18	limbs/digits/tail phenotype	MP:0005371	27.3	RECK, RELA, KIT, SFRP1, SFRP2, SFRP5
19	endocrine/exocrine gland phenotype	MP:0005379	26.7	ZNF148, KLF4, KLF5, PDCD4, REG1A, KISS1
20	craniofacial phenotype	MP:0005382	25.0	KLF4, NCOA3, REV3L, KIT, PCGF2, LPAR1
21	adipose tissue phenotype	MP:0005375	24.0	PIK3CA, PIK3R1, NCOA3, RETN, SFRP1, BUB1B
22	respiratory system phenotype	MP:0005388	18.8	KLF5, RBPJ, SELL, SELP, BRCA1, LPAR2
23	pigmentation phenotype	MP:0001186	17.7	KIT, RB1, RBPJ, BRAF, BRCA1, LMX1A
24	other phenotype	MP:0005395	17.6	RECK, BUB1, SERPINH1, VASP, RARG, RARA
25	immune system phenotype	MP:0005387	INF	ZNF148, PIAS1, KLF5, NCOA3, PDCD4, RETNLB
26	liver/biliary system phenotype	MP:0005370	INF	KLF6, NCOA3, RECK, RETN, KIT, BUB1
27	hearing/vestibular/ear phenotype	MP:0005377	INF	NCOA3, KIT, RB1, LMX1A, VANGL1, MYC
28	cardiovascular system phenotype	MP:0005385	INF	ZNF148, PIK3CB, PIK3CA, PIK3R1, PIK3CG, PINX1
29	mortality/aging	MP:0010768	INF	ZNF148, PIK3CB, PIK3CA, PIAS1, PINX1, KLF4

Articles related to gastric cancer:

(show top 50)    (show all 3354)

id	Title	Authors	Year	Affiliating Genes
1	MicroRNA-125a-5p is an independent prognostic factor in gastric cancer and inhibits the proliferation of human gastric cancer cells in combination with trastuzumab. (21220473)	Nishida N.... Mori M.	2011	MIR125A
2	The hOGG1 gene 5'-UTR variant c.-53G>C contributes to the risk of gastric cancer but not colorectal cancer in the Chinese populat ion: the functional variation of hOGG1 for gastric cancer risk. (21822670)	Liu X.... Wang Y.	2011	OGG1
3	Polymorphisms of interleukin-10 promoter are not asso ciated with prognosis of advanced gastric cancer. (21455338)	Liu J.... Wang Z.H.	2011	IL10
4	Association of a MYCL1 single nucleotide polymorphism , rs3134613, with susceptibility to diffuse-type gastric cancer and with differ entiation of gastric cancer in a southeast Chinese population. (20874233)	Chen S.Q.... Lin J.Y.	2010	MYCL1
5	Mechanistic study of nimesulide on enhancing gammade ltaT cell-mediated killing of gastric cancer cells (20230693)	Liu J.Q.... Zhang J.	2010	GZMB, KLRK1
6	MTHFR polymorphisms in gastric cancer and in first-de gree relatives of patients with gastric cancer. (20237899)	De Re V.... Toffoli G.	2010	MTHFR
7	EpCAM is overexpressed in gastric cancer and its down regulation suppresses proliferation of gastric cancer. (19294417)	Wenqi D.... Daiming F.	2009	EPCAM
8	Adipocytokine levels in gastric cancer patients: resi stin and visfatin as biomarkers of gastric cancer. (19430715)	Nakajima T.E.... Shimada Y.	2009	LEP, ADIPOQ, RETN
9	Epigenetic inactivation of protein kinase D1 in gastric cancer and its role in gastric cancer cell migration and invasion. (18283041)	Kim M.... Kim Y.S.	2008	PKD1, PRKD1
10	Bile acid induces expression of COX-2 through the homeodomain transcription factor CDX1 and orphan nuclear receptor SHP in human gastric cancer cells. (18775915)	Park M.J.... Cheong J.	2008	PTGS2, NR0B2, CDX1
11	Expression of phosphatase of regenerating liver-3 in gastric cancer, its relationship with prognosis, and its role in gastric cancer cell proliferation (19087692)	Cai S.R.... Zhan W.H.	2008	PTP4A3
12	Human macrophage metalloelastase expression in gastric cancer and its relationship with gastric cancer prognosis. (17987796)	Zhang H.... Xu G.	2007	MMP12
13	Gastric cancer susceptibility is not linked to pro-and anti-inflammatory cytokine gene polymorphisms in whites: a Nationwide Multicenter Study in Spain. (17640324)	Garcia-Gonzalez M.A.... Zaballa M.	2007	TGFB1, TNF, IL1B
14	Epidermal growth factor receptor antibody plus recombinant human endostatin in treatment of hepatic metastases after remnant gastric cancer resection. (18023113)	Sun L.... Wu H.	2007	EGFR, EGF
15	VEGF-C and VEGF-A synergistically enhance lymph node metastasis of gastric cancer. (17409493)	Kondo K.... Konno H.	2007	VEGFA, VEGFC
16	Early-onset gastric cancers have a different molecular expression profile than conventional gastric cancers. (16474375)	Milne A.N.... Offerhaus G.J.	2006	PTGS2, TFF1, ELAVL1
17	Effects of inhibition of cyclooxygenase-2 by RNA interference on proliferation and apoptosis of human gastric cancer cells: an experimental study with human gastric cancer cells and mice (16677508)	Wang B.H.... Hou X.H.	2006	PTGS1
18	A p53 genetic polymorphism of gastric cancer: difference between early gastric cancer and advanced gastric cancer. (17072987)	Yi S.Y.... Lee W.J.	2006	TP53
19	Skeletal muscle apoptosis is not increased in gastric cancer patients with mild-moderate weight loss. (16697691)	Bossola M.... Doglietto G.B.	2006	CASP1, CASP3
20	Expression of survivin in gastric cancer and its relationship with tumor angiogenesis. (16894308)	Lee G.H.... Kim S.J.	2006	VEGFA, BIRC5
21	Systematic search for gastric cancer-specific genes based on SAGE data: melanoma inhibitory activity and matrix metalloproteinase-10 are novel prognostic factors in patients with gastric cancer. (16331256)	Aung P.P.... Yasui W.	2006	MMP10, MIA, HORMAD1
22	High frequency occurrence of 1-OPRD variant of PRNP gene in gastric cancer cell lines and Chinese population with gastric cancer. (16914329)	Liang J.... Fan D.	2006	PRNP
23	Growth effect of gastrin on gastric cancer and its clinical implications for gastric cancer surgery. (16012719)	Lee H.K.... Yang H.K.	2005	CCKBR, GAST
24	Identification of gastric cancer-related genes using a cDNA microarray containing novel expressed sequence tags expressed in gastric cancer cells. (15701830)	Kim J.M.... Kim N.S.	2005	CDC20, PRMT5
25	G1P3, an interferon inducible gene 6-16, is expressed in gastric cancers and inhibits mitochondrial-mediated apoptosis in gastric cancer cell line TMK-1 cell. (15685448)	Tahara E. Jr.... Tahara E.	2005	PSEN2, CIB1, IFI6
26	IGFBP-2 mRNA expression in gastric cancer tissues and its roles in proliferation, differentiation and peritoneal metastasis of gastric cancer (15807262)	He T.... Qian K.	2005	IGFBP2
27	Cytokine gene polymorphisms in gastric cancer patients from two Italian areas at high and low cancer prevalence. (15927855)	Perri F.... Andriulli A.	2005	TNF, IL1B, IL1RN
28	Demethylation of the synuclein gamma gene CpG island in primary gastric cancers and gastric cancer cell lines. (15073123)	Yanagawa N.... Motoyama T.	2004	SNCG
29	Identification of novel genes associated with the response to 5-FU treatment in gastric cancer cell lines using a cDNA microarray. (15331170)	Park J.S.... Kim N.S.	2004	UMPS
30	Depleted dopamine in gastric cancer tissues: dopamine treatment retards growth of gastric cancer by inhibiting angiogenesis. (15240521)	Chakroborty D.... Basu S.	2004	KDR
31	Mutational analysis of BRAF and K-ras in gastric cancers: absence of BRAF mutations in gastric cancers. (14513361)	Kim I.J.... Park J.G.	2003	BRAF, KRAS
32	Micrometastases in sentinel nodes of gastric cancer. (12915877)	Ajisaka H.... Miwa K.	2003	KRT18
33	Expression of CD40 in gastric cancer and its effect on the apoptosis of gastric cancer cells (14634346)	Kim S.W.... Park D.H.	2003	ANXA5
34	Hypermethylation of the TSLC1 gene promoter in primary gastric cancers and gastric cancer cell lines. (12716461)	Honda T.... Murakami Y.	2002	CADM1
35	Inhibition of activator protein-1 on the growth of gastric cancer by octreotide (12478891)	Wang C.H.... Tang C.W.	2002	FOS, JUN, SST
36	E-cadherin gene variants in gastric cancer families whose probands are diagnosed with diffuse gastric cancer. (12216071)	Yabuta T.... Yokota J.	2002	CDH1, CTNNB1
37	Reduced PTEN expression in gastric cancer and in the gastric mucosa of gastric cancer relatives. (11953696)	Fei G.... Malfertheiner P.	2002	PTEN, PTPN3
38	Screening E-cadherin in gastric cancer families reveals germline mutations only in hereditary diffuse gastric cancer kindred. (11968083)	Oliveira C.... Caldas C.	2002	CDH1
39	Incidence of gastric cancer and breast cancer in CDH1 (E-cadherin) mutation carriers from hereditary diffuse gastric cancer families. (11729114)	Pharoah P.D.... Caldas C.	2001	CDH1
40	Gastric cancer and human leukocyte antigen: distinct DQ and DR alleles are associated with development of gastric cancer and infection by Helicobacter pylori. (11289148)	Magnusson PKE .... Gyllensten U.B.	2001	HLA-DQA1, HLA-DRB1
41	Clinical implications of immunoreactivity of thymidylate synthase and dihydropyrimidine dehydrogenase in gastric cancer treated with oral fluoropyrimidine (S-1). Study Group of S-1 for Gastric Cancer. (10995874)	Miyamoto S.... Fukushima M.	2000	TYMS, DPYD
42	Expression of transforming growth factor beta-1 in gastric cancer and in the gastric mucosa of first-degree relatives of patients with gastric cancer. (10839293)	Ebert M.P.... Malfertheiner P.	2000	TGFB1
43	Expression of heat shock protein 90 beta in human gastric cancer tissue and SGC7901/VCR of MDR-type gastric cancer cell line. (11721455)	Liu X.... Fan D.	1999	HSP90AB1
44	Participation of c-met in the progression of human gastric cancers: anti-c-met oligonucleotides inhibit proliferation or invasiveness of gastric cancer cells. (8988842)	Kaji M.... Yamamoto H.	1996	MET
45	Expression of oncoproteins and the amount of eosinophilic and lymphocytic infiltrates can be used as prognostic factors in gastric cancer. Dutch Gastric Cancer Group (DGCG). (8956793)	Songun I.... van Krieken J.H.	1996	RB1
46	Relationship between peritoneal collagen type IV concentrations and the presence of disseminated metastases in gastric cancer. (7611868)	Korenaga D.... Sugimachi K.	1995	CEACAM5
47	Serum-soluble interleukin-2 receptor concentrations in patients with gastric cancer. (7525035)	Murakami S.... Hashimoto T.	1994	IL2RA, CEACAM5
48	The prognostic significance of proliferating cell nuclear antigen in clinical gastric cancer. (8099452)	Mori M.... Steele G.D.	1993	PCNA
49	p53 gene mutations in human gastric cancer: wild-type p53 but not mutant p53 suppresses growth of human gastric cancer cells. (1322785)	Matozaki T.... Nagao M.	1992	TP53
50	p53 gene mutations in gastric cancer metastases and in gastric cancer cell lines derived from metastases. (1933850)	Yamada Y.... Terada M.	1991	TP53

Genes related to gastric cancer according to GeneCards:

(show top 50)    (show all 1416)

id	Symbol	Description	Score	GeneCards Section Context
1	CAPN9	calpain 9	11.1	Publications, Functions, Summaries
2	GKN2	gastrokine 2	11.0	Publications, Aliases & Descriptions
3	CASP10	caspase 10, apoptosis-related cysteine peptidase	11.0	Publications, Summaries
4	FAM72D	family with sequence similarity 72, member D	11.0	Aliases & Descriptions, Functions
5	KCMF1	potassium channel modulatory factor 1	11.0	Publications, Aliases & Descriptions, Functions
6	IL1RN	interleukin 1 receptor antagonist	11.0	Publications, Summaries
7	GKN1	gastrokine 1	11.0	Publications, Expressions, Summaries
8	CTSE	cathepsin E	11.0	Publications, Summaries
9	WNT9A	wingless-type MMTV integration site family, member 9A	11.0	Summaries
10	IQGAP1	IQ motif containing GTPase activating protein 1	11.0	Publications, Summaries
11	TGFBR1	transforming growth factor, beta receptor 1	11.0	Publications, Summaries
12	WNT3	wingless-type MMTV integration site family, member 3	11.0	Summaries
13	TACC1	transforming, acidic coiled-coil containing protein 1	11.0	Expressions, Publications, Aliases & Descriptions
14	CLDN23	claudin 23	11.0	Publications, Summaries
15	CAPN8	calpain 8	11.0	Summaries
16	CAPNS2	calpain, small subunit 2	11.0	Summaries
17	PGC	progastricsin (pepsinogen C)	11.0	Publications, Summaries
18	CAPN12	calpain 12	11.0	Summaries
19	FUCA2	fucosidase, alpha-L- 2, plasma	11.0	Publications, Summaries
20	CAPN11	calpain 11	11.0	Summaries
21	CAPN14	calpain 14	11.0	Summaries
22	CAPN6	calpain 6	11.0	Summaries
23	CAPN7	calpain 7	11.0	Summaries
24	CAPNS1	calpain, small subunit 1	11.0	Summaries
25	PRKD2	protein kinase D2	11.0	Publications, Summaries
26	CAPN1	calpain 1, (mu/I) large subunit	11.0	Publications, Summaries
27	CAPN10	calpain 10	11.0	Summaries
28	CAPN13	calpain 13	11.0	Summaries
29	CAPN2	calpain 2, (m/II) large subunit	11.0	Summaries
30	CAPN3	calpain 3, (p94)	11.0	Summaries
31	CAPN5	calpain 5	11.0	Summaries
32	RRP7A	ribosomal RNA processing 7 homolog A (S. cerevisiae)	11.0	Publications, Aliases & Descriptions
33	NUCB2	nucleobindin 2	11.0	Publications, Aliases & Descriptions
34	SERF2	small EDRK-rich factor 2	11.0	Aliases & Descriptions
35	CAPRIN2	caprin family member 2	11.0	Aliases & Descriptions
36	EMCN	endomucin	11.0	Publications, Aliases & Descriptions
37	NAA15	N(alpha)-acetyltransferase 15, NatA auxiliary subunit	11.0	Expressions, Publications, Aliases & Descriptions
38	PPHLN1	periphilin 1	11.0	Publications, Aliases & Descriptions
39	TROVE2	TROVE domain family, member 2	11.0	Aliases & Descriptions
40	CDH1	cadherin 1, type 1, E-cadherin (epithelial)	11.0	Publications
41	VEZT	vezatin, adherens junctions transmembrane protein	11.0	Summaries
42	ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	11.0	Publications, Functions
43	CEACAM5	carcinoembryonic antigen-related cell adhesion molecule 5	11.0	Publications
44	TYMP	thymidine phosphorylase	11.0	Publications
45	MUTYH	mutY homolog (E. coli)	11.0	Publications
46	IRF1	interferon regulatory factor 1	11.0	Publications
47	CDH3	cadherin 3, type 1, P-cadherin (placental)	11.0	Publications
48	DPYD	dihydropyrimidine dehydrogenase	11.0	Publications
49	APC	adenomatous polyposis coli	11.0	Publications
50	FGFR2	fibroblast growth factor receptor 2	11.0	Publications

Pathways related to gastric cancer according to GeneDecks:

(show top 50)    (show all 281)

id	Pathway	Score	Top Affiliating Genes
1	Rho Family GTPases36	28.2	PIK3R1, KIT, SEMA5A, VIM, VEGFC, BMP2
2	MAPK Signaling36	26.6	PIK3R1, KIT, SEMA5A, BRAF, VEGFC, VCL
3	MAPK Family Pathway36	24.5	PIK3R1, SEMA5A, BRAF, VEGFC, BMP2, BMP4
4	Estrogen Pathway36	21.9	PIK3R1, NCOA3, KIT, SEMA5A, BRAF, BRCA1
5	STAT3 Pathway36	21.0	PIM1, BRAF, MYC, BMP2, BMP4, BMP6
6	Mitochondrial Apoptosis36	20.7	PIK3R1, KIT, SEMA5A, VEGFC, BMP2, BMP4
7	Renin-Angiotensin Pathway36	20.4	PIK3R1, KIT, SEMA5A, VEGFC, VCAM1, BMP2
8	Activation of cAMP-Dependent PKA36	20.3	GCG, SEMA5A, VEGFC, VASP, BMP2, BMP4
9	JNK Pathway36	20.2	PIK3R1, KIT, SEMA5A, BMP2, BMP4, BMP6
10	eNOS Signaling36	19.9	PIK3R1, KIT, SEMA5A, BMP2, BMP6, BMP7
11	14-3-3 Induced Intracellular Signaling36	19.4	PIK3R1, SEMA5A, VEGFC, BMP2, BMP4, BMP7
12	Activation of PKC through GPCR36	19.2	PIK3R1, KIT, SEMA5A, VEGFC, BMP2, BMP4
13	MAPK signaling pathway20	19.1	RELA, BRAF, MYC, RAF1, RAC1, PAK1
14	NF-KappaB (p50-p65) Pathway36	18.9	PIK3R1, RELA, BTRC, SEMA5A, VEGFC, BMP2
15	Rap1 Pathway36	18.8	SEMA5A, BRAF, VEGFC, BMP2, BMP4, BMP6
16	WNT Signaling36	18.2	BTRC, VIM, MYC, RAC1, BIRC5, CLDN1
17	mTOR Pathway36	18.2	PIK3R1, SEMA5A, VEGFC, BMP2, BMP4, BMP6
18	Hepatitis C20	17.8	PIK3CB, PIK3CA, PIK3R1, PIAS1, PIK3CG, RELA
19	Signaling Involved in Cardiac Hypertrophy36	17.2	PIK3R1, BRAF, RAF1, RAC1, JUN, JAK2
20	TGF-beta Signaling Pathways37	17.0	PIK3CB, PIK3R1, PIK3CG, RELA, BRAF, MYC
21	Toxoplasmosis20	17.0	PIK3CB, PIK3CA, PIK3R1, PIK3CG, RELA, BIRC2
22	Chagas disease (American trypanosomiasis)20	17.0	PIK3CB, PIK3CA, PIK3R1, PIK3CG, RELA, SERPINE1
23	Small cell lung cancer20	16.5	PIK3CB, PIK3CA, PIK3R1, PIAS1, PIK3CG, RELA
24	Development_VEGF signaling via VEGFR2 - generic cascades41	16.0	PIK3CB, PIK3CA, PIK3R1, RELA, VEGFA, VCL
25	14-3-3 Induced Apoptosis36	16.0	PIK3R1, BID, BCL2, YWHAB, BAD, JUN
26	Presenilin-Mediated Signaling36	16.0	BTRC, BCL2, BCL2L1, UBD, UBC, AXIN1
27	Neurotrophin signaling pathway20	15.6	PIK3CB, PIK3CA, PIK3CG, RELA, BRAF, RAF1
28	Cell adhesion ECM remodeling10	15.6	VTN, SERPINE2, SERPINE1, VCAN, LAMB3, LAMC2
29	Cell adhesion_ECM remodeling41	15.5	VTN, SERPINE2, SERPINE1, VCAN, LAMB3, LAMC2
30	Selected targets of Oct-3/410	15.3	KLF4, BRCA1, VEGFC, BMI1, BMP4, RARA
31	Development IGF-RI signaling10	15.2	PIK3CB, PIK3CA, PIK3R1, RELA, MYC, RAF1
32	Apoptosis and survival_Role of CDK5 in neuronal death and survival41	15.2	PIK3CB, PIK3CA, PIK3R1, RAF1, BCL2, BAD
33	Apoptosis through Death Receptors36	15.1	BID, BIRC2, BIRC3, BCL2, BAX, CFLAR
34	Development_HGF signaling pathway41	14.9	PIK3CB, PIK3CA, PIK3R1, RAF1, RAC1, SDC1
35	Non-small cell lung cancer20	14.6	PIK3CB, PIK3CA, PIK3R1, PIK3CG, RB1, BRAF
36	Apoptosis and survival FAS signaling cascades10	14.6	BID, BIRC2, PARP1, BCL2, BCL2L11, BAX
37	Adhesion3	14.3	VCL, CLDN1, MTDH, CEACAM5, CEACAM1, JUP
38	Apoptotic Pathways Triggered By HIV136	14.3	BID, BIRC2, BIRC3, BCL2, BCL2L1, BAK1
39	ErbB Family Pathway36	14.3	PIK3R1, BRAF, RAF1, PAK1, PAK4, JUN
40	RAR-Gamma-RXR-Alpha Degradation36	14.2	BMP2, BMP4, BMP7, RARG, UBD, UBC
41	Amoebiasis20	14.2	PIK3CB, PIK3CA, PIK3R1, RELA, SERPINB2, VCL
42	Cell cycle ESR1 regulation of G1/S transition10	13.9	NCOA3, BTRC, RB1, RBX1, MYC, JUN
43	Development VEGF signaling via VEGFR2 - generic cascades10	13.7	PIK3CB, PIK3CA, PIK3R1, RELA, VEGFA, RAF1
44	Cell cycle_ESR1 regulation of G1/S transition41	13.3	NCOA3, BTRC, RB1, RBX1, MYC, UBC
45	Development VEGF signaling and activation10	13.3	PIK3CB, PIK3CA, PIK3R1, RELA, SELE, VCAM1
46	VEGF Signaling Pathway34	13.3	VEGFA, VEGFC, RAF1, KDR, ITGAV, FLT1
47	ErbB2-ErbB3 Heterodimers36	13.2	PIK3R1, RAF1, BAD, ITPR1, ITPR3, FOXO3
48	Adipocytokines & Insulin Signaling37	12.8	PIK3CB, PIK3R1, PIK3CG, RETN, BRAF, LEP
49	Apoptosis and survival_Anti-apoptotic action of membrane-bound ESR141	12.0	PIK3CB, PIK3R1, BAD, MAPK3, MAP3K5, MAP2K1
50	EGFR Inhibitor Pathway, Pharmacodynamics34	11.2	HRAS, PLCG2, KRAS, STAT5A

Compounds related to gastric cancer according to GeneDecks:

(show top 50)    (show all 475)

id	Compound	Score	Top Affiliating Genes
1	serine32	77.1	PIK3CB, PIK3CA, PIK3R1, PIAS1, PIK3CG, PIN1
2	estrogen32	53.1	PIK3CB, PIK3R1, PIAS1, KLF5, KLF6, NCOA3
3	actinomycin d32	37.7	PIK3CA, PIK3CG, RETN, KIT, RB1, SELE
4	5fluorouracil32	32.6	PIK3CA, PIK3CG, KIT, PCNA, GCG, RB1
5	lactate32	32.5	PIK3CA, RECK, KIT, VWF, VTN, PCNA
6	arginine32	31.5	PIK3CA, PIAS1, RFC1, NCOA3, RECK, VWF
7	etoposide32 42 9 9	34.2	PIK3CB, PIK3CA, PIK3R1, PIK3CG, RECK, PCNA
8	5-aza-2deoxycytidine32	27.7	SFRP1, PCNA, SERPINB5, VIM, BRCA1, VHL
9	ly29400232	26.4	PIK3CB, PIK3CA, PIK3R1, PIK3CG, RETN, VTN
10	herbimycin a32 42	23.8	PIK3CG, VTN, SELE, SELL, VCAM1, MYC
11	nmda32 42	20.6	PIK3CA, RELN, KISS1R, VIM, BLZF1, BCL2L1
12	ag 147832	19.4	PIK3CA, PIK3CG, SERPINE1, RAF1, MUC5AC, BAK1
13	geldanamycin32 9 9	20.8	PIK3R1, PIK3CG, PIM1, SETD2, BRAF, VEGFA
14	phorbol32	18.7	SELL, SERPINB2, MYC, RAF1, RAC1, CHGA
15	phospholipid32	18.5	PIK3CB, PIK3R1, PIP5KL1, VWF, RCVRN, SERPINA1
16	carboplatin32 34 9 9	20.9	RB1, BRCA1, VEGFA, BID, PARP1, BDKRB2
17	suramin32 9 9	19.8	RECK, PCNA, VEGFA, BMP6, RAF1, KDR
18	daunorubicin32 9 9	19.5	RELA, MYC, RAF1, BIRC5, BCL2, BCL2L1
19	gold32	17.3	RECK, KIT, SERPINA3, BRAF, BRCA1, VCL
20	heparan sulfate32 18	18.3	VTN, SERPINF2, SERPINE1, VIM, BSG, VCAN
21	glycerol32 9 18 9	20.0	VWF, PCNA, GCG, BRCA1, LPAR1, LEP
22	calpeptin32 42	17.8	BID, PARP1, BAX, CDC25C, ITGAL, ANXA5
23	p00332	16.6	RETN, KIT, RB1, SERPINA1, SERPINE1, BRCA1
24	manganese superoxide32	16.4	SERPINB2, VCAM1, BCL2L1, XRCC1, ATM, CD14
25	mifepristone32 42 9 9	19.1	BIRC5, BCL2L1, LGALS4, MUC1, BAX, LBR
26	sialic acid32	15.5	RECK, SELL, SERPINF2, SERPINA3, CLU, LGALS1
27	copper32 18	16.5	SERPINA1, BLZF1, LGALS1, MT2A, MT1G, MT-CO2
28	rottlerin32 42	16.4	PIK3R1, PIK3CG, VCAM1, RAC1, PARP1, XIAP
29	phosphatidylcholine32	15.4	PIK3CB, SELE, VIM, VCAM1, RAF1, RAC1
30	tunicamycin32	15.2	PIK3CG, RECK, CLU, MUC2, CD44, GTDC2
31	thyroxine32 18	15.7	RETN, VWF, PCNA, SERPINF2, SERPINA3, BGLAP
32	salicylic acid32	14.5	PIK3CG, SERPINA1, MYC, BCL2L1, XDH, CD40
33	pentoxifylline32 9 9	16.5	SELL, SELP, VCAM1, BMP2, BMP6, LBR
34	p0000132	14.4	SERPINE1, BRAF, VEGFC, BIRC5, MTHFR, S100A8
35	choline32 9 18 9	17.2	PIP5KL1, VIM, RAF1, LEPR, CHKA, CHRNA7
36	sulindac sulfide32	14.2	PCNA, BMP6, BCL2, BCL2L1, BAX, JUN
37	theophylline32 9 18 9	17.1	SELL, SELP, MYC, RAF1, CHGA, XDH
38	radicicol32 42 9 9	16.9	PIK3CG, VEGFA, RAF1, JUN, AR, GSN
39	octreotide32 42 9 9	16.9	GCG, VEGFA, CHGA, MPO, MME, MMP2
40	phenethyl isothiocyanate32	13.8	MYC, BID, PARP1, BCL2, BCL2L1, BAX
41	gsno32	13.7	SELP, SETD2, XDH, JUN, CDKN3, FN1
42	pkcs32	13.6	PIK3CB, PIK3R1, PIK3CG, RAF1, FOS, GRP
43	s-nitroso-n-acetylpenicillamine32	13.4	PARP1, XDH, FN1, IL1B, IL8, ANXA5
44	n-formylmethionyl-leucylphenylalanine32	13.4	PIK3CG, VTN, SELL, SELP, LCN2, MST1
45	p00532	13.2	SERPINB5, BRCA1, BIRC5, S100A8, MKI67, MC1R
46	etanercept32 9 9	15.2	LEP, MMP1, MMP12, MMP3, FCGR2A, FCGR3A
47	3,3-diindolylmethane32	12.8	VEGFA, BIRC5, PARP1, BAX, CFLAR, CDK6
48	warfarin32 34 9 18 9	16.4	VWF, SELP, NAT2, BGLAP, MTHFR, AXL
49	apocynin32	12.3	SELE, SETD2, VCAM1, RAC1, XDH, MPO
50	okt332	11.6	SELE, VCAM1, BMP6, LBR, CD40LG, IL10

Cellular components related to gastric cancer according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	cytoplasm	GO:005737	67.1	PIP5KL1, PIK3CG, PIN1, PINX1, PIM1, KLF6
2	plasma membrane	GO:005886	53.7	PIK3R1, PIK3CG, PIM1, RECK, KIT, KIAA1524
3	extracellular region	GO:005576	38.0	REG1A, REG4, RETN, RETNLB, KISS1, VWCE
4	extracellular space	GO:005615	33.3	RELN, KIT, VTN, SFRP1, SFRP2, SFRP5
5	nucleoplasm	GO:005654	32.9	PIAS1, PIN1, RFC1, NCOA3, RELA, PCNA
6	integral to plasma membrane	GO:005887	29.7	SELL, SELP, LPAR1, LPAR2, LPAR3, CLDN4
7	cell surface	GO:009986	20.8	KISS1R, SFRP1, VEGFA, LPAR1, LPAR2, VCAM1
8	perinuclear region of cytoplasm	GO:048471	19.9	BUB1B, SELE, RAD51, CLU, YWHAB, BAG1
9	proteinaceous extracellular matrix	GO:005578	17.0	RELN, VWF, SFRP1, SERPINA1, VEGFA, VCAN
10	basolateral plasma membrane	GO:016323	15.9	CHRM3, CEACAM5, ATP7A, CD44, CDH17, CD46
11	external side of plasma membrane	GO:009897	15.6	KIT, VWF, SELL, SELP, VCAM1, KDR
12	platelet alpha granule lumen	GO:031093	12.5	VWF, SERPINF2, SERPINA1, SERPINE1, VEGFA, VEGFC
13	nucleus	GO:005634	INF	ZNF160, ZNF664, ZNF148, PIK3CB, PIAS1, PIN1
14	cytosol	GO:005829	INF	PIK3CB, PIK3CA, PIK3R1, PIK3CG, NDC80, PDCD4

Biological processes related to gastric cancer according to GeneDecks:

(show top 50)    (show all 77)

id	Name	GO ID	Score	Top Affiliating Genes
1	apoptotic process	GO:006915	31.7	PIM1, PDCD4, SFRP5, BUB1, BUB1B, VIM
2	signal transduction	GO:007165	31.4	PIK3CB, KIT, SFRP5, RCVRN, GCG, BTRC
3	positive regulation of transcription from RNA polymerase II promoter	GO:045944	28.3	ZNF148, KLF12, KLF4, KLF6, NCOA3, RELA
4	positive regulation of transcription, DNA-dependent	GO:045893	26.4	PIAS1, KLF4, KLF5, KLF6, NCOA3, RELA
5	negative regulation of cell proliferation	GO:008285	25.5	PINX1, KLF4, KISS1R, SFRP1, SFRP2, SFRP5
6	negative regulation of transcription from RNA polymerase II promoter	GO:000122	24.3	ZNF148, KLF12, KLF4, PCGF2, RBPJ, VHL
7	positive regulation of cell proliferation	GO:008284	24.1	KLF5, REG1A, KIT, SFRP1, SFRP2, VEGFA
8	negative regulation of apoptotic process	GO:043066	23.9	PIK3CG, PIM1, RELA, SFRP1, PCGF2, GCG
9	blood coagulation	GO:007596	22.9	PIK3CB, PIK3CA, PIK3R1, PIK3CG, KIF2C, VWF
10	proteolysis	GO:006508	22.8	RELN, VHL, CMA1, SCRN1, UBD, LCN1
11	response to drug	GO:042493	22.5	SFRP1, SFRP2, VEGFC, MYC, BGLAP, BDKRB2
12	cell proliferation	GO:008283	21.8	PIM1, RETNLB, KIF2C, PCNA, BUB1, BUB1B
13	negative regulation of transcription, DNA-dependent	GO:045892	20.8	ZNF148, KLF4, PDCD4, RELA, SFRP1, SFRP2
14	virus-host interaction	GO:019048	19.9	PIK3R1, RELA, BUB1, BTRC, RB1, RBX1
15	anti-apoptosis	GO:006916	19.7	PIK3CA, RELA, SERPINB2, VIMP, BRAF, VHL
16	positive regulation of apoptotic process	GO:043065	19.7	SFRP1, SFRP2, LPAR1, BMP2, BMP4, RARG
17	inflammatory response	GO:006954	19.4	PIK3CG, RELA, KIT, SELE, SELP, SERPINA3
18	innate immune response	GO:045087	19.3	PIK3CG, PIN1, RELA, CLU, BCL2, BCL2L1
19	protein phosphorylation	GO:006468	18.8	PIM1, BRAF, RARA, RAF1, LIMK1, BIRC5
20	cell-cell signaling	GO:007267	18.2	SFRP2, SEMA5A, BMP2, S100A9, CEACAM6, MLN
21	induction of apoptosis	GO:006917	17.5	NAIF1, BOK, BNIP3, USP7, BIK, BCL2L11
22	platelet activation	GO:030168	16.6	PIK3CB, PIK3CA, PIK3R1, PIK3CG, VWF, SELP
23	response to organic cyclic compound	GO:014070	16.4	SFRP1, BTG2, SELP, SERPINA1, BMP4, UGT1A1
24	epidermal growth factor receptor signaling pathway	GO:007173	16.4	PIK3CA, PIK3R1, RAF1, YWHAB, UBC, BAD
25	heart development	GO:007507	16.2	PCNA, VCAM1, VCAN, BMP2, RAF1, ATM
26	protein autophosphorylation	GO:046777	16.0	PIM1, KIT, PAK1, KDR, CHEK2, MTOR
27	fibroblast growth factor receptor signaling pathway	GO:008543	16.0	PIK3CA, PIK3R1, BRAF, RAF1, YWHAB, UBC
28	positive regulation of cell migration	GO:030335	15.9	VEGFA, BMP2, KDR, S1PR1, JAK2, ITGAV
29	response to estradiol stimulus	GO:032355	15.9	SERPINA1, BMP4, RARA, BID, AURKA, MMP9
30	cell surface receptor signaling pathway	GO:007166	15.8	BSG, BIRC2, BIRC3, BDKRB2, LEPR, BAG1
31	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	15.8	PDCD6, BOK, MYC, BCL2L10, BCL2L11, BAD
32	positive regulation of ERK1 and ERK2 cascade	GO:070374	15.7	GCG, SERPINF2, BRAF, BMP2, BMP4, KDR
33	cytokine-mediated signaling pathway	GO:019221	15.7	PIAS1, PIN1, KLF6, RELA, KIT, VCAM1
34	positive regulation of angiogenesis	GO:045766	15.7	SFRP2, SERPINE1, VEGFA, KDR, CHI3L1, CHRNA7
35	negative regulation of cell growth	GO:030308	15.6	SFRP1, SFRP2, RB1, SERPINE2, BCL2, BCL6
36	positive regulation of protein phosphorylation	GO:001934	15.6	PIN1, VEGFA, BMP2, BMP4, MTOR, AXIN1
37	response to ethanol	GO:045471	15.2	BGLAP, BCL2, BAK1, S100A8, S100A9, FYN
38	aging	GO:007568	15.2	VCAM1, BAK1, JUN, GSN, IL1B, FAS
39	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	15.1	RELA, LPAR1, BIRC2, BIRC3, LGALS1, UBD
40	response to lipopolysaccharide	GO:032496	15.1	SELE, SELP, SERPINA1, UGT1A1, S100A8, S100A9
41	leukocyte migration	GO:050900	14.7	PIK3CB, PIK3CA, PIK3R1, SELL, SELP, BSG
42	activation of MAPK activity	GO:000187	14.6	PIK3CB, KIT, LPAR1, LPAR2, LPAR3, CHRNA7
43	positive regulation of endothelial cell proliferation	GO:001938	14.3	VEGFA, BMP2, BMP4, BMP6, KDR, MTOR
44	cellular response to hypoxia	GO:071456	13.5	SFRP1, RBX1, VHL, VEGFA, BNIP3, BMP7
45	positive regulation of protein kinase B signaling cascade	GO:051897	13.4	PIK3CG, CHI3L1, MTDH, MTOR, AXL, MST1R
46	platelet degranulation	GO:002576	13.4	VWF, SELP, SERPINF2, SERPINA1, SERPINE1, VEGFA
47	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	13.3	RELN, VTN, VEGFA, MTOR, JAK2, CD44
48	positive regulation of MAPK cascade	GO:043410	12.7	KIT, LPAR1, LPAR2, LPAR3, KDR, LEP
49	positive regulation of NF-kappaB transcription factor activity	GO:051092	12.6	RELA, CLU, UBC, MTDH, CD40, IRAK1
50	small molecule metabolic process	GO:044281	INF	PIK3CB, PIK3CA, PIK3R1, PIK3CG, NCOA3, GCG

Molecular functions related to gastric cancer according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	100.0	ZNF148, PIK3CB, PIK3CA, PIK3R1, PIAS1, PIK3CG
2	ATP binding	GO:005524	32.5	PIK3CB, PIK3CA, PIP5KL1, PIK3CG, PIM1, RFC1
3	protein homodimerization activity	GO:042803	24.5	PDCD6, KIT, VWF, SERPINF2, VEGFA, BNIP3
4	identical protein binding	GO:042802	20.0	RELA, SFRP1, PCNA, VIM, BNIP3, RAD51
5	protein heterodimerization activity	GO:046982	19.8	BRAF, VEGFA, BOK, BNIP3, MYC, BMP2
6	protein kinase binding	GO:019901	18.8	RELA, VIM, PAK1, BCL2L1, CHEK2, BAD
7	transcription factor binding	GO:008134	18.4	PIM1, RELA, RB1, VHL, MYC, RARA
8	enzyme binding	GO:019899	18.0	PIAS1, VIMP, BRCA1, VHL, RARA, RAC1
9	growth factor activity	GO:008083	17.5	REG1A, VEGFA, VEGFC, BMP2, BMP4, BMP6
10	receptor binding	GO:005102	17.2	GCG, SERPINE2, SERPINE1, BMP2, RARA, KCNA5
11	transcription regulatory region DNA binding	GO:044212	16.7	KLF4, RELA, BRCA1, ZFHX3, CIITA, YAP1
12	protein kinase activity	GO:004672	16.0	PIK3CG, BUB1, BUB1B, BRAF, RAF1, LIMK1
13	cytokine activity	GO:005125	15.7	VEGFA, BMP2, BMP4, BMP6, BMP7, SCGB3A1
14	ubiquitin protein ligase binding	GO:031625	15.5	RELA, RB1, RBX1, BRCA1, USP7, BLZF1