MCID: GST063
MIFTS: 37

Gastric Cancer Risk After H. Pylori Infection malady

Genetic diseases, Gastrointestinal diseases, Cancer diseases, Rare diseases categories
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Summaries for Gastric Cancer Risk After H. Pylori Infection

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47OMIM, 33MalaCards
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MalaCards: Gastric Cancer Risk After H. Pylori Infection, also known as hereditary malignant neoplasm, is related to hereditary diffuse gastric cancer and familial adenomatous polyposis. An important gene associated with Gastric Cancer Risk After H. Pylori Infection is IL1RN (interleukin 1 receptor antagonist), and among its related pathways are NOD-like Receptor Signaling Pathways and SIDS Susceptibility Pathways. The compounds anakinra and toxin-1 have been mentioned in the context of this disorder. Affiliated tissues include breast, and related mouse phenotypes are tumorigenesis and mortality/aging.

Description from OMIM:47 137215

Aliases & Classifications for Gastric Cancer Risk After H. Pylori Infection

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49Orphanet, 47OMIM, 62UMLS, 26ICD10 via Orphanet
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Classifications:



Characteristics (Orphanet epidemiological data):

49
familial stomach cancer:
Inheritance: Multigenic/multifactorial; Age of onset: Adulthood


Aliases & Descriptions:

gastric cancer risk after h. pylori infection 47
hereditary malignant neoplasm 62
familial stomach cancer 49
familial gastric cancer 49


External Ids:

OMIM47 137215
ICD10 via Orphanet26 C16

Related Diseases for Gastric Cancer Risk After H. Pylori Infection

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Gastric Cancer Risk After H. Pylori Infection:



Diseases related to gastric cancer risk after h. pylori infection

Symptoms for Gastric Cancer Risk After H. Pylori Infection

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47OMIM
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Symptoms by clinical synopsis from OMIM:

137215

Clinical features from OMIM:

137215

Drugs & Therapeutics for Gastric Cancer Risk After H. Pylori Infection

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Gastric Cancer Risk After H. Pylori Infection

Search NIH Clinical Center for Gastric Cancer Risk After H. Pylori Infection

Genetic Tests for Gastric Cancer Risk After H. Pylori Infection

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Anatomical Context for Gastric Cancer Risk After H. Pylori Infection

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33MalaCards
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MalaCards organs/tissues related to Gastric Cancer Risk After H. Pylori Infection:

33
Breast

Animal Models for Gastric Cancer Risk After H. Pylori Infection or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Gastric Cancer Risk After H. Pylori Infection:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.4CDH1, IL1B, MUTYH
2MP:00107688.0CDH1, IL1B, IL1RN, MUTYH
3MP:00053767.7MUTYH, IL1RN, IL1B, CDH1

Publications for Gastric Cancer Risk After H. Pylori Infection

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Variations for Gastric Cancer Risk After H. Pylori Infection

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64UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar), 7dbSNP
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UniProtKB/Swiss-Prot genetic disease variations for Gastric Cancer Risk After H. Pylori Infection:

64
id Symbol AA change Variation ID SNP ID
1CDH1p.Asp244GlyVAR_008712
2CDH1p.Val487AlaVAR_008713
3CDH1p.Val832MetVAR_023358rs35572355

Clinvar genetic disease variations for Gastric Cancer Risk After H. Pylori Infection:

1 (show all 19)
id Gene Name Type Significance SNP ID Assembly Location
1CDH1NM_004360.3(CDH1): c.1849G> A (p.Ala617Thr)single nucleotide variantBenign, Pathogenicrs33935154GRCh37Chr 16, 68856041: 68856041
2CDH1NM_004360.3(CDH1): c.781G> T (p.Glu261Ter)single nucleotide variantPathogenicrs121964873GRCh37Chr 16, 68844193: 68844193
3CDH1CDH1, 1-BP INS, 2382CinsertionPathogenic
4CDH1NM_004360.3(CDH1): c.2095C> T (p.Gln699Ter)single nucleotide variantPathogenicrs121964874GRCh37Chr 16, 68857460: 68857460
5CDH1CDH1, IVS1AS, A-G, -2single nucleotide variantPathogenic
6CDH1NM_004360.3(CDH1): c.59G> A (p.Trp20Ter)single nucleotide variantPathogenicrs121964875GRCh37Chr 16, 68772210: 68772210
7CDH1NM_004360.3(CDH1): c.70G> T (p.Glu24Ter)single nucleotide variantPathogenicrs121964876GRCh37Chr 16, 68772221: 68772221
8CDH1NM_004360.3(CDH1): c.1792C> T (p.Arg598Ter)single nucleotide variantPathogenicrs121964877GRCh37Chr 16, 68855984: 68855984
9CDH1CDH1, 1-BP INS, 1711GinsertionPathogenic
10CDH1CDH1, 1-BP INS, 1588CinsertionPathogenic
11CDH1NM_004360.3(CDH1): c.1901C> T (p.Ala634Val)single nucleotide variantPathogenicrs121964878GRCh37Chr 16, 68856093: 68856093
12CDH1NM_004360.3(CDH1): c.1018A> G (p.Thr340Ala)single nucleotide variantPathogenic, Uncertain significancers116093741GRCh37Chr 16, 68846047: 68846047
13CDH1NM_004360.3(CDH1): c.2494G> A (p.Val832Met)single nucleotide variantPathogenic, Uncertain significancers35572355GRCh37Chr 16, 68867247: 68867247
14CDH1nsv513771deletionPathogenic
15CDH1CDH1, 828-BP DEL/3-BP INS, EX16indelPathogenic
16CDH1NM_004360.3(CDH1): c.1565+1G> Asingle nucleotide variantPathogenicGRCh38Chr 16, 68815760: 68815760
17CDH1NM_004360.3(CDH1): c.1003C> T (p.Arg335Ter)single nucleotide variantPathogenicGRCh38Chr 16, 68811854: 68811854
18CDH1NM_004360.3(CDH1): c.2287G> T (p.Glu763Ter)single nucleotide variantPathogenicGRCh38Chr 16, 68828296: 68828296
19CDH1NM_004360.3(CDH1): c.1008G> T (p.Glu336Asp)single nucleotide variantPathogenicrs267606712GRCh37Chr 16, 68845762: 68845762

Expression for genes affiliated with Gastric Cancer Risk After H. Pylori Infection

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gastric Cancer Risk After H. Pylori Infection

Search GEO for disease gene expression data for Gastric Cancer Risk After H. Pylori Infection.

Pathways for genes affiliated with Gastric Cancer Risk After H. Pylori Infection

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50PathCards, 54R&D Systems, 60Thomson Reuters, 38NCBI BioSystems Database, 55Reactome
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Pathways related to Gastric Cancer Risk After H. Pylori Infection according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.3IL1B, IL1RN
29.3IL1B, IL1RN
3
Show member pathways
9.3IL1B, IL1RN
4
Show member pathways
IL-1 Signaling Pathway38
IL1-mediated signaling events38
9.3IL1B, IL1RN

Compounds for genes affiliated with Gastric Cancer Risk After H. Pylori Infection

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45Novoseek, 11DrugBank, 51PharmGKB, 24HMDB, 29IUPHAR, 61Tocris Bioscience, 3BitterDB
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Compounds related to Gastric Cancer Risk After H. Pylori Infection according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idCompoundScoreTop Affiliating Genes
1anakinra45 1110.8IL1RN, IL1B
2toxin-1459.8IL1B, IL1RN
3gold sodium thiomalate459.8IL1B, IL1RN
4lansoprazole45 51 24 1112.8IL1RN, IL1B
5cuprophan459.8IL1B, IL1RN
6polysulfone459.8IL1RN, IL1B
7polymyxin b459.7IL1B, IL1RN
8leflunomide45 51 1111.7IL1B, IL1RN
9lipoteichoic acid459.7IL1B, IL1RN
10sulfasalazine29 45 51 1112.7IL1B, IL1RN
11ns 39845 6110.7IL1RN, IL1B
12alginate459.7IL1RN, IL1B
13etanercept45 51 1111.7IL1B, IL1RN
14il 10459.7IL1RN, IL1B
15l-nmma459.7IL1B, IL1RN
16infliximab45 51 1111.7IL1B, IL1RN
17peptidoglycan45 2910.7IL1B, IL1RN
18ivig459.7IL1RN, IL1B
19pentoxifylline45 1110.7IL1B, IL1RN
20ibuprofen45 29 51 24 1113.7IL1B, IL1RN
21neopterin459.7IL1RN, IL1B
22corticosterone45 61 2411.6IL1RN, IL1B
23leukotriene b445 61 2411.6IL1B, IL1RN
24chi 2459.6CDH1, IL1RN
25p00001459.5IL1RN, CDH1
26hydrocortisone45 3 61 1112.5IL1RN, IL1B
27chloroquine45 3 51 29 1113.4CDH1, IL1RN
28polyethylene glycol459.4CDH1, IL1RN
29latex459.4CDH1, IL1RN
30p003459.4IL1RN, CDH1
31sodium dodecylsulfate459.4IL1RN, CDH1
32celecoxib45 61 29 51 24 1114.4CDH1, IL1B
33p002459.3CDH1, IL1RN
34adenine45 24 1111.2CDH1, MUTYH
35troglitazone45 29 61 1112.1CDH1, IL1B
36formaldehyde45 2410.1CDH1, IL1RN
37carbohydrates459.0CDH1, IL1RN
38mg 13245 6110.0IL1B, CDH1
39tgf beta1459.0CDH1, IL1B, IL1RN
40hyaluronic acid45 2410.0CDH1, IL1B, IL1RN
41aspirin45 51 29 2412.0IL1RN, IL1B, CDH1
42methotrexate51 45 1111.0CDH1, IL1B, IL1RN
43indomethacin45 29 61 1111.9CDH1, IL1B, IL1RN
44sb 20358045 619.9IL1RN, IL1B, CDH1
45histamine45 29 2410.9CDH1, IL1B, IL1RN
46pge2458.9CDH1, IL1B, IL1RN
47dexamethasone45 51 29 1111.8CDH1, IL1B, IL1RN
48vegf458.8IL1RN, IL1B, CDH1
49herbimycin a45 619.7CDH1, IL1B
50retinoic acid45 249.7CDH1, IL1B, IL1RN

GO Terms for genes affiliated with Gastric Cancer Risk After H. Pylori Infection

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16Gene Ontology
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Biological processes related to Gastric Cancer Risk After H. Pylori Infection according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fever generationGO:0016609.3IL1B, IL1RN

Molecular functions related to Gastric Cancer Risk After H. Pylori Infection according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:0051499.0IL1B, IL1RN
2protein domain specific bindingGO:0199049.0CDH1, IL1B

Products for genes affiliated with Gastric Cancer Risk After H. Pylori Infection

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Sources for Gastric Cancer Risk After H. Pylori Infection

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet