MCID: GST063
MIFTS: 37

Gastric Cancer Risk After H. Pylori Infection malady

Genetic diseases, Gastrointestinal diseases, Cancer diseases, Rare diseases categories

Summaries for Gastric Cancer Risk After H. Pylori Infection

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48OMIM, 34MalaCards
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MalaCards: Gastric Cancer Risk After H. Pylori Infection, also known as hereditary malignant neoplasm, is related to hereditary diffuse gastric cancer and familial adenomatous polyposis. An important gene associated with Gastric Cancer Risk After H. Pylori Infection is IL1RN (interleukin 1 receptor antagonist), and among its related pathways are NOD-like Receptor Signaling Pathways and SIDS Susceptibility Pathways. The compounds anakinra and toxin-1 have been mentioned in the context of this disorder. Affiliated tissues include breast, and related mouse phenotypes are tumorigenesis and mortality/aging.

Description from OMIM:48 137215

Aliases & Classifications for Gastric Cancer Risk After H. Pylori Infection

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50Orphanet, 48OMIM, 63UMLS, 27ICD10 via Orphanet
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Classifications:



Characteristics (Orphanet epidemiological data):

50
familial stomach cancer:
Inheritance: Multigenic/multifactorial; Age of onset: Adulthood


Aliases & Descriptions:

gastric cancer risk after h. pylori infection 48
hereditary malignant neoplasm 63
familial stomach cancer 50
familial gastric cancer 50


External Ids:

OMIM48 137215
ICD10 via Orphanet27 C16

Related Diseases for Gastric Cancer Risk After H. Pylori Infection

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Gastric Cancer Risk After H. Pylori Infection:



Diseases related to gastric cancer risk after h. pylori infection

Symptoms for Gastric Cancer Risk After H. Pylori Infection

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48OMIM
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Symptoms by clinical synopsis from OMIM:

137215

Clinical features from OMIM:

137215

Drugs & Therapeutics for Gastric Cancer Risk After H. Pylori Infection

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Gastric Cancer Risk After H. Pylori Infection

Drug clinical trials:

Search ClinicalTrials for Gastric Cancer Risk After H. Pylori Infection

Search NIH Clinical Center for Gastric Cancer Risk After H. Pylori Infection

Search CenterWatch for Gastric Cancer Risk After H. Pylori Infection

Genetic Tests for Gastric Cancer Risk After H. Pylori Infection

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Anatomical Context for Gastric Cancer Risk After H. Pylori Infection

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34MalaCards
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MalaCards organs/tissues related to Gastric Cancer Risk After H. Pylori Infection:

34
Breast

Animal Models for Gastric Cancer Risk After H. Pylori Infection or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Gastric Cancer Risk After H. Pylori Infection:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.4CDH1, IL1B, MUTYH
2MP:00107688.0CDH1, IL1B, IL1RN, MUTYH
3MP:00053767.7MUTYH, IL1RN, IL1B, CDH1

Publications for Gastric Cancer Risk After H. Pylori Infection

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Variations for Gastric Cancer Risk After H. Pylori Infection

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65UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar), 8dbSNP
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UniProtKB/Swiss-Prot genetic disease variations for Gastric Cancer Risk After H. Pylori Infection:

65
id Symbol AA change Variation ID SNP ID
1CDH1p.Asp244GlyVAR_008712
2CDH1p.Val487AlaVAR_008713
3CDH1p.Val832MetVAR_023358rs35572355

Clinvar genetic disease variations for Gastric Cancer Risk After H. Pylori Infection:

1 (show all 19)
id Gene Name Type Significance SNP ID Assembly Location
1CDH1NM_004360.3(CDH1): c.1849G> A (p.Ala617Thr)single nucleotide variantBenign, Pathogenicrs33935154GRCh37Chr 16, 68856041: 68856041
2CDH1NM_004360.3(CDH1): c.781G> T (p.Glu261Ter)single nucleotide variantPathogenicrs121964873GRCh37Chr 16, 68844193: 68844193
3CDH1CDH1, 1-BP INS, 2382CinsertionPathogenic
4CDH1NM_004360.3(CDH1): c.2095C> T (p.Gln699Ter)single nucleotide variantPathogenicrs121964874GRCh37Chr 16, 68857460: 68857460
5CDH1CDH1, IVS1AS, A-G, -2single nucleotide variantPathogenic
6CDH1NM_004360.3(CDH1): c.59G> A (p.Trp20Ter)single nucleotide variantPathogenicrs121964875GRCh37Chr 16, 68772210: 68772210
7CDH1NM_004360.3(CDH1): c.70G> T (p.Glu24Ter)single nucleotide variantPathogenicrs121964876GRCh37Chr 16, 68772221: 68772221
8CDH1NM_004360.3(CDH1): c.1792C> T (p.Arg598Ter)single nucleotide variantPathogenicrs121964877GRCh37Chr 16, 68855984: 68855984
9CDH1CDH1, 1-BP INS, 1711GinsertionPathogenic
10CDH1CDH1, 1-BP INS, 1588CinsertionPathogenic
11CDH1NM_004360.3(CDH1): c.1901C> T (p.Ala634Val)single nucleotide variantPathogenicrs121964878GRCh37Chr 16, 68856093: 68856093
12CDH1NM_004360.3(CDH1): c.1018A> G (p.Thr340Ala)single nucleotide variantPathogenic, Uncertain significancers116093741GRCh37Chr 16, 68846047: 68846047
13CDH1NM_004360.3(CDH1): c.2494G> A (p.Val832Met)single nucleotide variantPathogenic, Uncertain significancers35572355GRCh37Chr 16, 68867247: 68867247
14CDH1nsv513771deletionPathogenic
15CDH1CDH1, 828-BP DEL/3-BP INS, EX16indelPathogenic
16CDH1NM_004360.3(CDH1): c.1565+1G> Asingle nucleotide variantPathogenicGRCh38Chr 16, 68815760: 68815760
17CDH1NM_004360.3(CDH1): c.1003C> T (p.Arg335Ter)single nucleotide variantPathogenicGRCh38Chr 16, 68811854: 68811854
18CDH1NM_004360.3(CDH1): c.2287G> T (p.Glu763Ter)single nucleotide variantPathogenicGRCh38Chr 16, 68828296: 68828296
19CDH1NM_004360.3(CDH1): c.1008G> T (p.Glu336Asp)single nucleotide variantPathogenicrs267606712GRCh37Chr 16, 68845762: 68845762

Expression for genes affiliated with Gastric Cancer Risk After H. Pylori Infection

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gastric Cancer Risk After H. Pylori Infection

Search GEO for disease gene expression data for Gastric Cancer Risk After H. Pylori Infection.

Pathways for genes affiliated with Gastric Cancer Risk After H. Pylori Infection

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51PathCards, 55R&D Systems, 61Thomson Reuters, 39NCBI BioSystems Database, 56Reactome
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Pathways related to Gastric Cancer Risk After H. Pylori Infection according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways61
Immune response IL 1 signaling pathway61
9.3IL1B, IL1RN
29.3IL1B, IL1RN
3
Show member pathways
9.3IL1B, IL1RN
4
Show member pathways
IL-1 Signaling Pathway39
IL1-mediated signaling events39
9.3IL1B, IL1RN

Compounds for genes affiliated with Gastric Cancer Risk After H. Pylori Infection

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 25HMDB, 30IUPHAR, 62Tocris Bioscience, 3BitterDB
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Compounds related to Gastric Cancer Risk After H. Pylori Infection according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idCompoundScoreTop Affiliating Genes
1anakinra46 1210.8IL1RN, IL1B
2toxin-1469.8IL1B, IL1RN
3gold sodium thiomalate469.8IL1B, IL1RN
4lansoprazole46 52 25 1212.8IL1RN, IL1B
5cuprophan469.8IL1B, IL1RN
6polysulfone469.8IL1RN, IL1B
7polymyxin b469.7IL1B, IL1RN
8leflunomide46 52 1211.7IL1B, IL1RN
9lipoteichoic acid469.7IL1B, IL1RN
10sulfasalazine30 46 52 1212.7IL1B, IL1RN
11ns 39846 6210.7IL1RN, IL1B
12alginate469.7IL1RN, IL1B
13etanercept46 52 1211.7IL1B, IL1RN
14il 10469.7IL1RN, IL1B
15l-nmma469.7IL1B, IL1RN
16infliximab46 52 1211.7IL1B, IL1RN
17peptidoglycan46 3010.7IL1B, IL1RN
18ivig469.7IL1RN, IL1B
19pentoxifylline46 1210.7IL1B, IL1RN
20ibuprofen46 30 52 25 1213.7IL1B, IL1RN
21neopterin469.7IL1RN, IL1B
22corticosterone46 62 2511.6IL1RN, IL1B
23leukotriene b446 62 2511.6IL1B, IL1RN
24chi 2469.6CDH1, IL1RN
25p00001469.5IL1RN, CDH1
26hydrocortisone46 3 62 1212.5IL1RN, IL1B
27chloroquine46 3 52 30 1213.4CDH1, IL1RN
28polyethylene glycol469.4CDH1, IL1RN
29latex469.4CDH1, IL1RN
30p003469.4IL1RN, CDH1
31sodium dodecylsulfate469.4IL1RN, CDH1
32celecoxib46 62 30 52 25 1214.4CDH1, IL1B
33p002469.3CDH1, IL1RN
34adenine46 25 1211.2CDH1, MUTYH
35troglitazone46 30 62 1212.1CDH1, IL1B
36formaldehyde46 2510.1CDH1, IL1RN
37carbohydrates469.0CDH1, IL1RN
38mg 13246 6210.0IL1B, CDH1
39tgf beta1469.0CDH1, IL1B, IL1RN
40hyaluronic acid46 2510.0CDH1, IL1B, IL1RN
41aspirin46 52 30 2512.0IL1RN, IL1B, CDH1
42methotrexate52 46 1211.0CDH1, IL1B, IL1RN
43indomethacin46 30 62 1211.9CDH1, IL1B, IL1RN
44sb 20358046 629.9IL1RN, IL1B, CDH1
45histamine46 30 2510.9CDH1, IL1B, IL1RN
46pge2468.9CDH1, IL1B, IL1RN
47dexamethasone46 52 30 1211.8CDH1, IL1B, IL1RN
48vegf468.8IL1RN, IL1B, CDH1
49herbimycin a46 629.7CDH1, IL1B
50retinoic acid46 259.7CDH1, IL1B, IL1RN

GO Terms for genes affiliated with Gastric Cancer Risk After H. Pylori Infection

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17Gene Ontology
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Biological processes related to Gastric Cancer Risk After H. Pylori Infection according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fever generationGO:0016609.3IL1B, IL1RN

Molecular functions related to Gastric Cancer Risk After H. Pylori Infection according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:0051499.0IL1B, IL1RN
2protein domain specific bindingGO:0199049.0CDH1, IL1B

Products for genes affiliated with Gastric Cancer Risk After H. Pylori Infection

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  • Antibodies
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Sources for Gastric Cancer Risk After H. Pylori Infection

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet