MCID: GST063
MIFTS: 36

Gastric Cancer Risk After H. Pylori Infection malady

Gastrointestinal diseases, Cancer diseases, Genetic diseases categories

Summaries for Gastric Cancer Risk After H. Pylori Infection

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46OMIM, 32MalaCards
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MalaCards: Gastric Cancer Risk After H. Pylori Infection, also known as hereditary malignant neoplasm, is related to hereditary diffuse gastric cancer and colorectal cancer. An important gene associated with Gastric Cancer Risk After H. Pylori Infection is IL1RN (interleukin 1 receptor antagonist), and among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Immune response Bacterial infections in normal airways. The compounds pge2 and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include breast, and related mouse phenotype tumorigenesis.

Description from OMIM:46 137215

Aliases & Classifications for Gastric Cancer Risk After H. Pylori Infection

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48Orphanet, 46OMIM, 60UMLS, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Genetic diseases
Anatomical: Gastrointestinal diseases


Characteristics (Orphanet epidemiological data):

48
familial stomach cancer:
Inheritance: Multigenic/multifactorial; Age of onset: Adulthood


Aliases & Descriptions:

gastric cancer risk after h. pylori infection 46
hereditary malignant neoplasm 60
familial stomach cancer 48
familial gastric cancer 48


External Ids:

OMIM46 137215
ICD10 via Orphanet26 C16

Related Diseases for Gastric Cancer Risk After H. Pylori Infection

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17GeneCards, 18GeneDecks
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Diseases related to Gastric Cancer Risk After H. Pylori Infection via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1hereditary diffuse gastric cancer30.0CDH1
2colorectal cancer30.0CDH1, MUTYH
3stomach cancer, familial10.2
4li-fraumeni syndrome10.2
5familial colorectal cancer10.0
6familial prostate cancer10.0
7familial adenomatous polyposis10.0
8juvenile polyposis syndrome10.0
9breast cancer10.0
10chordoma10.0
11dengue shock syndrome10.0IL1RN
12polymyalgia rheumatica10.0IL1RN
13silicosis10.0IL1RN
14pneumonia10.0IL1B
15degenerative disc disease10.0IL1B
16bacterial vaginosis10.0IL1B
17gingivitis10.0IL1B
18duodenal ulcer10.0IL1RN
19pleurisy10.0IL1B
20endometriosis10.0IL1B
21periodontitis10.0IL1B
22alopecia areata10.0IL1RN
23peritonitis10.0IL1B
24bronchopulmonary dysplasia10.0IL1RN
25mastitis10.0IL1B
26psoriasis10.0IL1B
27pemphigus vulgaris10.0CDH1
28gastrointestinal system disease10.0CDH1
29esophageal cancer10.0CDH1
30galactosemia10.0IL1B
31melanoma10.0CDH1
32adenocarcinoma10.0CDH1
33lung cancer10.0CDH1
34familial mediterranean fever10.0IL1B
35prostate cancer10.0CDH1
36respiratory failure10.0IL1B
37otitis media10.0IL1B
38chronic infantile neurological cutaneous articular syndrome10.0IL1B, IL1RN
39gastritis10.0IL1RN, IL1B
40cerebral malaria10.0IL1RN, IL1B
41pancreatitis10.0IL1B
42adult respiratory distress syndrome10.0IL1RN, IL1B
43newborn respiratory distress syndrome10.0IL1B, IL1RN
44toxic shock syndrome10.0IL1B, IL1RN
45chorioamnionitis10.0IL1RN, IL1B
46idiopathic pulmonary fibrosis10.0IL1B, IL1RN
47periodontal disease10.0IL1B, IL1RN
48inflammatory bowel disease10.0IL1RN, IL1B
49septic shock10.0IL1B, IL1RN
50adenoma10.0MUTYH, CDH1

Graphical network of the top 20 diseases related to Gastric Cancer Risk After H. Pylori Infection:



Diseases related to gastric cancer risk after h. pylori infection

Clinical Features for Gastric Cancer Risk After H. Pylori Infection

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46OMIM
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Clinical features from OMIM:

137215

Clinical synopsis from OMIM:

137215

Drugs & Therapeutics for Gastric Cancer Risk After H. Pylori Infection

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Gastric Cancer Risk After H. Pylori Infection

Search NIH Clinical Center for Gastric Cancer Risk After H. Pylori Infection

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Genetic Tests for Gastric Cancer Risk After H. Pylori Infection

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Anatomical Context for Gastric Cancer Risk After H. Pylori Infection

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32MalaCards
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MalaCards organs/tissues related to Gastric Cancer Risk After H. Pylori Infection:

32
Breast

Animal Models for Gastric Cancer Risk After H. Pylori Infection or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Gastric Cancer Risk After H. Pylori Infection:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5IL1B, CDH1, MUTYH

Publications for Gastric Cancer Risk After H. Pylori Infection

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Genetic Variations for Gastric Cancer Risk After H. Pylori Infection

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Gastric Cancer Risk After H. Pylori Infection:

62
id Symbol AA change Variation ID SNP ID
1CDH1p.Asp244GlyVAR_008712
2CDH1p.Val487AlaVAR_008713
3CDH1p.Val832MetVAR_023358rs35572355

Expression for genes affiliated with Gastric Cancer Risk After H. Pylori Infection

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gastric Cancer Risk After H. Pylori Infection

Search GEO for disease gene expression data for Gastric Cancer Risk After H. Pylori Infection.

Pathways for genes affiliated with Gastric Cancer Risk After H. Pylori Infection

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53Reactome, 37NCBI BioSystems Database
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Pathways related to Gastric Cancer Risk After H. Pylori Infection according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.3IL1B, IL1RN
2
Immune response Bacterial infections in normal airways
Hide members
9.3IL1B, IL1RN
3
Hide members
9.3IL1B, IL1RN

Compounds for genes affiliated with Gastric Cancer Risk After H. Pylori Infection

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Gastric Cancer Risk After H. Pylori Infection according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1pge24410.0CDH1
2dexamethasone44 49 28 1112.9CDH1
3anakinra44 1110.8IL1B, IL1RN
4toxin-1449.7IL1B, IL1RN
5gold sodium thiomalate449.7IL1RN, IL1B
6polysulfone449.7IL1RN, IL1B
7polymyxin b449.7IL1B, IL1RN
8leflunomide49 44 1111.7IL1B, IL1RN
9sulfasalazine44 28 49 1112.7IL1B, IL1RN
10lipoteichoic acid449.7IL1B, IL1RN
11alginate449.7IL1B, IL1RN
12ns 39844 5910.7IL1RN, IL1B
13etanercept44 49 1111.7IL1B, IL1RN
14il 10449.7IL1B, IL1RN
15infliximab44 49 1111.7IL1RN, IL1B
16l-nmma449.7IL1RN, IL1B
17peptidoglycan44 2810.6IL1RN, IL1B
18ivig449.6IL1RN, IL1B
19pentoxifylline44 1110.6IL1RN, IL1B
20ibuprofen44 28 49 11 2413.6IL1RN, IL1B
21neopterin449.6IL1B, IL1RN
22chi 2449.5CDH1, IL1RN
23p00001449.5CDH1, IL1RN
24corticosterone44 59 2411.5IL1B, IL1RN
25leukotriene b444 59 2411.4IL1B, IL1RN
26chloroquine44 2 49 28 1113.4CDH1, IL1RN
27polyethylene glycol449.3CDH1, IL1RN
28celecoxib44 59 28 49 11 2414.3IL1B, CDH1
29latex449.2CDH1, IL1RN
30sodium dodecylsulfate449.1CDH1, IL1RN
31p003449.0CDH1, IL1RN
32troglitazone44 28 59 1112.0IL1B, CDH1
33tgf beta1448.9IL1B, IL1RN, CDH1
34hyaluronic acid44 249.9CDH1, IL1RN, IL1B
35aspirin44 49 28 2411.9CDH1, IL1RN, IL1B
36methotrexate44 49 1110.9CDH1, IL1RN, IL1B
37sb 20358044 599.9IL1RN, CDH1, IL1B
38histamine44 28 2410.9CDH1, IL1RN, IL1B
39p002448.8IL1RN, CDH1
40vegf448.7CDH1, IL1RN, IL1B

GO Terms for genes affiliated with Gastric Cancer Risk After H. Pylori Infection

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16Gene Ontology
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Molecular functions related to Gastric Cancer Risk After H. Pylori Infection according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:0051499.3IL1B, IL1RN

Products for genes affiliated with Gastric Cancer Risk After H. Pylori Infection

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  • Antibodies
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Sources for Gastric Cancer Risk After H. Pylori Infection

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet