MCID: GST063
MIFTS: 26

Gastric Cancer Risk After H. Pylori Infection malady

Gastrointestinal, Cancer, Genetic categories

Summaries for Gastric Cancer Risk After H. Pylori Infection

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47OMIM, 33MalaCards
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MalaCards: Gastric Cancer Risk After H. Pylori Infection, also known as hereditary malignant neoplasm, is related to hereditary diffuse gastric cancer and adenoma. An important gene associated with Gastric Cancer Risk After H. Pylori Infection is IL1RN (interleukin 1 receptor antagonist), and among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Immune response Bacterial infections in normal airways. The compounds pge2 and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include breast, and related mouse phenotype tumorigenesis.

Description from OMIM:47 137215

Aliases & Classifications for Gastric Cancer Risk After H. Pylori Infection

Sources:
47OMIM, 49Orphanet, 61UMLS, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer, Genetic
Anatomical: Gastrointestinal


Characteristics (Orphanet epidemiological data):

49
familial stomach cancer:
Inheritance: Multigenic/multifactorial; Age of onset: Adulthood


Aliases & Descriptions:

gastric cancer risk after h. pylori infection 47
hereditary malignant neoplasm 61
familial stomach cancer 49
familial gastric cancer 49


External Ids:

OMIM47 137215
ICD10 via Orphanet26 C16

Related Diseases for Gastric Cancer Risk After H. Pylori Infection

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17GeneCards, 18GeneDecks
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Diseases related to Gastric Cancer Risk After H. Pylori Infection via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 59)
idRelated DiseaseScoreTop Affiliating Genes
1hereditary diffuse gastric cancer30.0CDH1
2adenoma30.0MUTYH, CDH1
3colorectal cancer30.0CDH1, MUTYH
4diffuse gastric cancer10.3
5stomach cancer, familial10.2
6familial prostate cancer10.1
7familial adenomatous polyposis10.1
8juvenile polyposis syndrome10.1
9attenuated familial adenomatous polyposis10.1
10familial breast cancer10.1
11familial colorectal cancer10.1
12mass syndrome10.1
13breast cancer, lobular10.1
14dengue shock syndrome10.0IL1RN
15polymyalgia rheumatica10.0IL1RN
16silicosis10.0IL1RN
17pneumonia10.0IL1B
18degenerative disc disease10.0IL1B
19bacterial vaginosis10.0IL1B
20gingivitis10.0IL1B
21duodenal ulcer10.0IL1RN
22pleurisy10.0IL1B
23endometriosis10.0IL1B
24periodontitis10.0IL1B
25alopecia areata10.0IL1RN
26peritonitis10.0IL1B
27bronchopulmonary dysplasia10.0IL1RN
28mastitis10.0IL1B
29psoriasis10.0IL1B
30pemphigus vulgaris10.0CDH1
31gastrointestinal system disease10.0CDH1
32esophageal cancer10.0CDH1
33galactosemia10.0IL1B
34melanoma10.0CDH1
35adenocarcinoma10.0CDH1
36lung cancer10.0CDH1
37familial mediterranean fever10.0IL1B
38prostate cancer10.0CDH1
39respiratory failure10.0IL1B
40otitis media10.0IL1B
41chronic infantile neurological cutaneous articular syndrome10.0IL1B, IL1RN
42gastritis10.0IL1RN, IL1B
43cerebral malaria10.0IL1RN, IL1B
44pancreatitis10.0IL1B
45adult respiratory distress syndrome10.0IL1RN, IL1B
46newborn respiratory distress syndrome10.0IL1B, IL1RN
47toxic shock syndrome10.0IL1B, IL1RN
48chorioamnionitis10.0IL1RN, IL1B
49idiopathic pulmonary fibrosis10.0IL1B, IL1RN
50periodontal disease10.0IL1B, IL1RN

Graphical network of the top 20 diseases related to Gastric Cancer Risk After H. Pylori Infection:



Diseases related to gastric cancer risk after h. pylori infection

Clinical Features for Gastric Cancer Risk After H. Pylori Infection

Sources:
47OMIM
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Clinical features from OMIM:

137215

Clinical synopsis from OMIM:

137215

Drugs & Therapeutics for Gastric Cancer Risk After H. Pylori Infection

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Gastric Cancer Risk After H. Pylori Infection

Drug clinical trials:

Search ClinicalTrials for Gastric Cancer Risk After H. Pylori Infection

Search NIH Clinical Center for Gastric Cancer Risk After H. Pylori Infection

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Genetic Tests for Gastric Cancer Risk After H. Pylori Infection

Anatomical Context for Gastric Cancer Risk After H. Pylori Infection

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33MalaCards
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MalaCards organs/tissues related to Gastric Cancer Risk After H. Pylori Infection:

33
Breast

Animal Models for Gastric Cancer Risk After H. Pylori Infection or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Gastric Cancer Risk After H. Pylori Infection:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5IL1B, CDH1, MUTYH

Publications for Gastric Cancer Risk After H. Pylori Infection

Genetic Variations for Gastric Cancer Risk After H. Pylori Infection

Sources:
63UniProtKB/Swiss-Prot
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Genetic disease variations for Gastric Cancer Risk After H. Pylori Infection:

63
id Symbol AA change Variation SNP ID
1CDH1p.Asp244GlyVAR_008712
2CDH1p.Val487AlaVAR_008713
3CDH1p.Val832MetVAR_023358rs35572355

Expression for genes affiliated with Gastric Cancer Risk After H. Pylori Infection

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gastric Cancer Risk After H. Pylori Infection

Search GEO for disease gene expression data for Gastric Cancer Risk After H. Pylori Infection.

Pathways for genes affiliated with Gastric Cancer Risk After H. Pylori Infection

Sources:
54Reactome, 38NCBI BioSystems Database
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Pathways related to Gastric Cancer Risk After H. Pylori Infection according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.3IL1B, IL1RN
2
Immune response Bacterial infections in normal airways
Hide members
9.3IL1B, IL1RN
3
Hide members
9.3IL1B, IL1RN

Compounds for genes affiliated with Gastric Cancer Risk After H. Pylori Infection

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 60Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Gastric Cancer Risk After H. Pylori Infection according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1pge24510.0CDH1
2dexamethasone45 50 29 1112.9CDH1
3anakinra45 1110.8IL1B, IL1RN
4toxin-1459.7IL1RN, IL1B
5gold sodium thiomalate459.7IL1B, IL1RN
6polysulfone459.7IL1B, IL1RN
7polymyxin b459.7IL1B, IL1RN
8leflunomide50 45 1111.7IL1B, IL1RN
9sulfasalazine45 29 50 1112.7IL1RN, IL1B
10lipoteichoic acid459.7IL1RN, IL1B
11ns 39845 6010.7IL1RN, IL1B
12alginate459.7IL1RN, IL1B
13etanercept45 50 1111.7IL1B, IL1RN
14il 10459.7IL1RN, IL1B
15infliximab45 50 1111.7IL1B, IL1RN
16l-nmma459.7IL1B, IL1RN
17peptidoglycan45 2910.6IL1RN, IL1B
18ivig459.6IL1B, IL1RN
19pentoxifylline45 1110.6IL1B, IL1RN
20ibuprofen45 29 50 11 2413.6IL1RN, IL1B
21neopterin459.6IL1B, IL1RN
22chi 2459.5IL1RN, CDH1
23p00001459.5CDH1, IL1RN
24corticosterone45 60 2411.5IL1B, IL1RN
25leukotriene b445 60 2411.4IL1RN, IL1B
26chloroquine45 2 50 29 1113.4IL1RN, CDH1
27polyethylene glycol459.3IL1RN, CDH1
28celecoxib45 60 29 50 11 2414.3IL1B, CDH1
29latex459.2IL1RN, CDH1
30sodium dodecylsulfate459.1CDH1, IL1RN
31p003459.0CDH1, IL1RN
32troglitazone45 29 60 1112.0IL1B, CDH1
33tgf beta1458.9IL1B, IL1RN, CDH1
34hyaluronic acid45 249.9IL1B, IL1RN, CDH1
35aspirin45 50 29 2411.9CDH1, IL1RN, IL1B
36methotrexate45 50 1110.9IL1B, IL1RN, CDH1
37sb 20358045 609.9CDH1, IL1RN, IL1B
38histamine45 29 2410.9IL1B, IL1RN, CDH1
39p002458.8IL1RN, CDH1
40vegf458.7CDH1, IL1RN, IL1B

GO Terms for genes affiliated with Gastric Cancer Risk After H. Pylori Infection

Sources:
16Gene Ontology
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Molecular functions related to Gastric Cancer Risk After H. Pylori Infection according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:0051499.3IL1B, IL1RN

Products for genes affiliated with Gastric Cancer Risk After H. Pylori Infection

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gastric Cancer Risk After H. Pylori Infection

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet