MCID: GST060
MIFTS: 45

Gastric Cancer, Somatic malady

Genetic diseases (common), Cancer diseases, Gastrointestinal diseases categories

Aliases & Classifications for Gastric Cancer, Somatic

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Aliases & Descriptions for Gastric Cancer, Somatic:

Name: Gastric Cancer, Somatic 46 9
Gastric Cancer 30 44
Gastric Cancer Gastric Cancer, Intestinal, Included 46
 
Malignant Neoplasm of Stomach 61
Stomach Carcinoma 61


Classifications:



External Ids:

OMIM46 613659
ICD1025 C16

Summaries for Gastric Cancer, Somatic

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OMIM:46 In a review article on the genetic predisposition to gastric cancer, Bevan and Houlston (1999) concluded that several... (613659) more...

MalaCards based summary: Gastric Cancer, Somatic, also known as gastric cancer, is related to stomach cancer and breast cancer, and has symptoms including somatic mutationand stomach cancer. An important gene associated with Gastric Cancer, Somatic is FGFR2 (fibroblast growth factor receptor 2), and among its related pathways are Alzheimers Disease Pathway and EGFR Signaling Pathway. The compounds 5-methylthioadenosine and regorafenib have been mentioned in the context of this disorder. Affiliated tissues include colon, and related mouse phenotypes are pigmentation and limbs/digits/tail.

Related Diseases for Gastric Cancer, Somatic

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Diseases related to Gastric Cancer, Somatic via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 234)
idRelated DiseaseScoreTop Affiliating Genes
1stomach cancer31.3ERBB2
2breast cancer30.7KRAS, PIK3CA
3colorectal cancer30.2APC, PIK3CA, KRAS
4gastric adenocarcinoma30.1PIK3CA, KRAS, APC, ERBB2
5lynch syndrome30.0MUTYH, KRAS, APC
6pancreatic cancer29.9ERBB2, KRAS, FGFR2, PIK3CA
7leukemia29.8IRF1, CASP10, PIK3CA, KRAS, FGFR2
8melanoma29.8KRAS, FGFR2, CASP10, IRF1, PIK3CA
9lung cancer29.7ERBB2, KRAS, PIK3CA
10adenocarcinoma29.7ERBB2, IRF1, PIK3CA, APC, KLF6, KRAS
11cholangiocarcinoma29.7PIK3CA, ERBB2, KRAS
12adenomatous polyposis coli29.5KRAS, IRF1, MUTYH, APC
13prostate cancer29.1KRAS, FGFR2, PIK3CA, APC, KLF6, ERBB2
14retinoblastoma28.9KRAS, IRF1, FGFR2, KLF6, ERBB2, PIK3CA
15hepatocellular carcinoma28.8MUTYH, KRAS, FGFR2, KLF6, IRF1, PIK3CA
16diffuse gastric cancer11.0
17peritonitis11.0
18gastritis11.0
19endotheliitis10.9
20atrophic gastritis10.8
21duodenitis10.7
22hypoxia10.7
23familial gastric cancer10.7
24esophagitis10.7
25h. pylori infection10.7
26duodenal ulcer10.6
27gastric ulcer10.5
28pancreatitis10.5
29peptic ulcer disease10.5
30prostatitis10.5
31hepatitis10.4
32gastric outlet obstruction10.4
33disseminated intravascular coagulation10.4
34microinvasive gastric cancer10.4
35cronkhite-canada syndrome10.4
36intestinal neoplasm10.3APC
37esophageal cancer10.3
38li-fraumeni syndrome10.3
39situs inversus10.3
40ataxia-telangiectasia10.3
41malt lymphoma10.3
42gastric lymphoma10.3
43linitis plastica10.3
44adenoma10.3
45pyloric stenosis10.3
46thyroiditis10.3
47ataxia10.3
48thrombocytosis10.2
49cardia cancer10.2
50obstructive jaundice10.2

Graphical network of the top 20 diseases related to Gastric Cancer, Somatic:



Diseases related to gastric cancer, somatic

Symptoms for Gastric Cancer, Somatic

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Clinical features from OMIM:

613659

HPO human phenotypes related to Gastric Cancer, Somatic:

id Description Frequency HPO Source Accession
1 somatic mutation HP:0001428
2 stomach cancer HP:0012126

Drugs & Therapeutics for Gastric Cancer, Somatic

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FDA approved drugs:

id Drug Name Active Ingredient(s)13 Pharmaceutical Company Approval Date
1
Cyramza13 38 RAMUCIRUMAB Eli Lilly Approved April 2014
FDA Label: Cyramza
Malady that Drug Treats: gastric cancer
Indications and Usage:13 CYRAMZA® is a human vascular endothelial growth factor receptor 2; antagonist indicated; as a single agent or in combination with paclitaxel, for treatment; of advanced gastric or gastro-esophageal junction; adenocarcinoma, with disease progression on or after prior; fluoropyrimidine- or platinum-containing chemotherapy. (1.1); in combination with docetaxel, for treatment of metastatic nonsmall; cell lung cancer with disease progression on or after; platinum-based chemotherapy. Patients with EGFR or ALK; genomic tumor aberrations should have disease progression on; FDA-approved therapy for these aberrations prior to receiving; CYRAMZA. (1.2); in combination with FOLFIRI, for the treatment of metastatic; colorectal cancer with disease progression on or after prior; therapy with bevacizumab, oxaliplatin, and a fluoropyrimidine.; (1.3)
DrugBank Targets: -
Mechanism of Action:13 
Target: ligand-stimulated activation of VEGF Receptor 2
Action: inhibitor
FDA: Ramucirumab is a vascular endothelial growth factor receptor 2 antagonist that specifically binds VEGF Receptor; 2 and blocks binding of VEGFR ligands, VEGF-A, VEGF-C, and VEGF-D. As a result, ramucirumab inhibits ligandstimulated; activation of VEGF Receptor 2, thereby inhibiting ligand-induced proliferation, and migration of human; endothelial cells. Ramucirumab inhibited angiogenesis in an in vivo animal model.
2
Herceptin13 38 TRASTUZUMAB Genentech Approved October 1998
FDA Label: Herceptin
Malady that Drug Treats: Breast cancer/gastric cancer
Indications and Usage:13 Herceptin is a HER2/neu receptor antagonist indicated for:; the treatment of HER2 overexpressing breast cancer (1.1, 1.2).; the treatment of HER2-overexpressing metastatic gastric or; gastroesophageal junction adenocarcinoma (1.3)
DrugBank Targets:11 1. Receptor tyrosine-protein kinase erbB-2; 2. Epidermal growth factor receptor; 3. Complement C1r subcomponent; 4. Complement C1q subcomponent subunit A; 5. Complement C1q subcomponent subunit B; 6. Complement C1q subcomponent subunit C; 7. Complement C1s subcomponent; 8. High affinity immunoglobulin gamma Fc receptor I; 9. Low affinity immunoglobulin gamma Fc region receptor II-a; 10. Low affinity immunoglobulin gamma Fc region receptor II-b; 11. Low affinity immunoglobulin gamma Fc region receptor II-c; 12. Low affinity immunoglobulin gamma Fc region receptor III-B; 13. Low affinity immunoglobulin gamma Fc region receptor III-A
Mechanism of Action:13 
Target: human epidermal growth factor receptor 2 protein (HER2)
Action: binds with strong affinity for immune response
FDA: The HER2 (or c-erbB2) proto-oncogene encodes a transmembrane receptor protein of 185 kDa, which is structurally related to the epidermal growth factor receptor. Herceptin has been shown, in both in vitro assays and in animals, to inhibit the proliferation of human tumor cells that overexpress HER2. Herceptin is a mediator of antibody-dependent cellular cytotoxicity (ADCC). In vitro, Herceptin-mediated ADCC has been shown to be preferentially exerted on HER2 overexpressing cancer cells compared with cancer cells that do not overexpress HER2.;

Drug clinical trials:

Search ClinicalTrials for Gastric Cancer, Somatic

Search NIH Clinical Center for Gastric Cancer, Somatic

Genetic Tests for Gastric Cancer, Somatic

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Anatomical Context for Gastric Cancer, Somatic

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MalaCards organs/tissues related to Gastric Cancer, Somatic:

31
Colon

Animal Models for Gastric Cancer, Somatic or affiliated genes

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MGI Mouse Phenotypes related to Gastric Cancer, Somatic:

35 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.1APC, FGFR2, KRAS
2MP:00053718.8FGFR2, KRAS, ERBB2, APC
3MP:00053708.8APC, KLF6, KRAS, FGFR2
4MP:00053678.7FGFR2, KRAS, IRF1, APC
5MP:00053818.6FGFR2, ERBB2, APC, KRAS
6MP:00028738.4IRF1, FGFR2, KRAS, ERBB2, APC
7MP:00053918.2PIK3CA, KRAS, FGFR2, APC
8MP:00053978.1FGFR2, KRAS, IRF1, APC, KLF6
9MP:00053698.1ERBB2, KRAS, APC, FGFR2, PIK3CA
10MP:00053797.8PIK3CA, FGFR2, KRAS, KLF6, APC, ERBB2
11MP:00053807.8APC, FGFR2, KRAS, ERBB2, KLF6, PIK3CA
12MP:00053897.7PIK3CA, APC, ERBB2, KLF6, KRAS, FGFR2
13MP:00053787.7PIK3CA, APC, ERBB2, KLF6, KRAS, FGFR2
14MP:00036317.5FGFR2, KRAS, ERBB2, PIK3CA, MUTYH, APC
15MP:00053867.5APC, ERBB2, PIK3CA, KRAS, FGFR2
16MP:00107717.3PIK3CA, KLF6, FGFR2, KRAS, APC, IRF1
17MP:00053857.3PIK3CA, APC, IRF1, ERBB2, FGFR2, KRAS
18MP:00020067.2PIK3CA, MUTYH, APC, ERBB2, KRAS, IRF1
19MP:00053767.1IRF1, ERBB2, KRAS, APC, PIK3CA, FGFR2
20MP:00053846.8FGFR2, KRAS, KLF6, ERBB2, PIK3CA, MUTYH
21MP:00107686.8ERBB2, MUTYH, FGFR2, KRAS, KLF6, IRF1

Publications for Gastric Cancer, Somatic

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Variations for Gastric Cancer, Somatic

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UniProtKB/Swiss-Prot genetic disease variations for Gastric Cancer, Somatic:

63 (show all 20)
id Symbol AA change Variation ID SNP ID
1APCp.Gly817CysVAR_005035
2APCp.Ile880ThrVAR_005036
3APCp.Asn942AspVAR_005039
4APCp.Gly1120GluVAR_005042rs28933379
5APCp.Arg1171HisVAR_005043
6APCp.Phe1197SerVAR_005045
7APCp.Ile1259ThrVAR_005046
8APCp.Gly1312GluVAR_005050
9APCp.Val1326AlaVAR_005052
10CASP10p.Met147ThrVAR_037428rs121909776
11IRF1p.Met8LeuVAR_065134
12IRF1p.Trp11ArgVAR_065135
13KRASp.Gly12ValVAR_006840
14KRASp.Gly12AspVAR_016026
15KRASp.Gly12SerVAR_016028
16KRASp.Gly13AspVAR_016029
17KRASp.Ala59ThrVAR_016030
18KRASp.Lys5AsnVAR_064849
19MUTYHp.Pro402SerVAR_026049
20MUTYHp.Gln411ArgVAR_026050

Clinvar genetic disease variations for Gastric Cancer, Somatic:

5 (show all 15)
id Gene Variation Type Significance SNP ID Assembly Location
1KRASNM_033360.3(KRAS): c.35G> A (p.Gly12Asp)single nucleotide variantPathogenic, drug responsers121913529GRCh37Chr 12, 25398284: 25398284
2KRASNM_033360.3(KRAS): c.34G> A (p.Gly12Ser)single nucleotide variantPathogenic, drug responsers121913530GRCh37Chr 12, 25398285: 25398285
3FGFR2NM_000141.4(FGFR2): c.799T> C (p.Ser267Pro)single nucleotide variantPathogenicrs121918505GRCh37Chr 10, 123279633: 123279633
4PIK3CANM_006218.2(PIK3CA): c.3140A> G (p.His1047Arg)single nucleotide variantPathogenicrs121913279GRCh37Chr 3, 178952085: 178952085
5PIK3CANM_006218.2(PIK3CA): c.1633G> A (p.Glu545Lys)single nucleotide variantPathogenicrs104886003GRCh37Chr 3, 178936091: 178936091
6PIK3CANM_006218.2(PIK3CA): c.3203dupA (p.Asn1068Lysfs)duplicationPathogenicGRCh37Chr 3, 178952148: 178952148
7ERBB2NM_001005862.2(ERBB2): c.2236G> A (p.Gly746Ser)single nucleotide variantPathogenicrs28933369GRCh37Chr 17, 37880997: 37880997
8IRF1NM_002198.2(IRF1): c.22A> T (p.Met8Leu)single nucleotide variantPathogenicrs121912469GRCh37Chr 5, 131825149: 131825149
9MUTYHNM_001128425.1(MUTYH): c.1213C> T (p.Pro405Ser)single nucleotide variantPathogenicrs121908382GRCh37Chr 1, 45797202: 45797202
10MUTYHNM_001128425.1(MUTYH): c.1241A> G (p.Gln414Arg)single nucleotide variantPathogenicrs121908383GRCh37Chr 1, 45797174: 45797174
11KLF6NM_001300.5(KLF6): c.465C> A (p.Ser155Arg)single nucleotide variantPathogenicrs121909144GRCh37Chr 10, 3824044: 3824044
12CASP10NM_032977.3(CASP10): c.769C> T (p.Gln257Ter)single nucleotide variantPathogenicrs121909775GRCh37Chr 2, 202070652: 202070652
13CASP10NM_032977.3(CASP10): c.440T> C (p.Met147Thr)single nucleotide variantPathogenicrs121909776GRCh37Chr 2, 202052521: 202052521
14APCNM_000038.5(APC): c.3359G> A (p.Gly1120Glu)single nucleotide variantPathogenicrs28933379GRCh37Chr 5, 112174650: 112174650
15APCNM_000038.5(APC): c.3199C> T (p.Gln1067Ter)single nucleotide variantPathogenicrs137854571GRCh37Chr 5, 112174490: 112174490

Expression for genes affiliated with Gastric Cancer, Somatic

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Search GEO for disease gene expression data for Gastric Cancer, Somatic.

Pathways for genes affiliated with Gastric Cancer, Somatic

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Pathways related to Gastric Cancer, Somatic according to GeneCards Suite gene sharing:

(show all 50)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8FGFR2, ERBB2
29.7ERBB2, CASP10
3
Show member pathways
9.6KRAS, FGFR2
4
Show member pathways
9.6KRAS, ERBB2
5
Show member pathways
Angiogenesis36
9.3PIK3CA, FGFR2
69.3FGFR2, PIK3CA
79.3PIK3CA, ERBB2
89.3PIK3CA, ERBB2
9
Show member pathways
9.3PIK3CA, ERBB2
109.3ERBB2, KRAS, FGFR2
11
Show member pathways
TRAIL signaling pathway36
9.2PIK3CA, CASP10
129.2IRF1, PIK3CA
13
Show member pathways
IFN-gamma pathway36
9.2IRF1, PIK3CA
149.1KRAS, PIK3CA
159.1PIK3CA, KRAS
169.1PIK3CA, KRAS
179.0PIK3CA, APC
189.0PIK3CA, APC
19
Show member pathways
8.8KRAS, FGFR2, PIK3CA
20
Show member pathways
8.8PIK3CA, KRAS, FGFR2
21
Show member pathways
8.8PIK3CA, KRAS, FGFR2
22
Show member pathways
8.8FGFR2, KRAS, PIK3CA
238.8FGFR2, KRAS, PIK3CA
24
Show member pathways
ErbB receptor signaling network36
ErbB signaling pathway36
8.8KRAS, PIK3CA, ERBB2
25
Show member pathways
Transcription Receptor mediated HIF regulation59
Development CNTF receptor signaling59
Class IB PI3K non-lipid kinase events36
ErbB2/ErbB3 signaling events36
Development Growth hormone signaling via PI3K AKT and MAPK cascades59
Translation Regulation activity of EIF259
Regulation of lipid metabolism Insulin signaling generic cascades59
Transcription PPAR Pathway59
Cell adhesion PLAU signaling59
Translation Regulation activity of EIF4F59
8.8KRAS, PIK3CA, ERBB2
26
Show member pathways
8.8ERBB2, PIK3CA, KRAS
278.8ERBB2, PIK3CA, KRAS
28
Show member pathways
Development EGFR signaling via PIP359
Development PDGF signaling via MAPK cascades59
Apoptosis and survival Anti apoptotic action of membrane bound ESR159
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases59
Development Neurotrophin family signaling59
Apoptosis and survival NGF signaling pathway59
Apoptosis and survival Role of CDK5 in neuronal death and survival59
8.8ERBB2, PIK3CA, KRAS
29
Show member pathways
8.7APC, CASP10, ERBB2, FGFR2
30
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.7CASP10, PIK3CA, KRAS
318.7PIK3CA, IRF1, KRAS
32
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes59
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway59
8.7KRAS, IRF1, PIK3CA
33
Show member pathways
8.7IRF1, KRAS, PIK3CA
348.5KRAS, APC, PIK3CA
35
Show member pathways
Signaling Pathways in Glioblastoma36
8.4KRAS, PIK3CA, FGFR2, ERBB2
368.4KRAS, PIK3CA, FGFR2, ERBB2
37
Show member pathways
8.4KRAS, FGFR2, ERBB2, PIK3CA
38
Show member pathways
8.4FGFR2, ERBB2, KRAS, PIK3CA
39
Show member pathways
8.4FGFR2, PIK3CA, ERBB2, KRAS
40
Show member pathways
8.4FGFR2, KRAS, ERBB2, PIK3CA
41
Show member pathways
8.4CASP10, FGFR2, PIK3CA, KRAS
42
Show member pathways
Prolactin Signaling Pathway36
Development Prolactin receptor signaling59
Leptin signaling pathway36
8.3PIK3CA, ERBB2, IRF1, KRAS
43
Show member pathways
8.2KRAS, PIK3CA, FGFR2, APC
448.1APC, PIK3CA, KRAS, ERBB2
45
Show member pathways
Signal transduction PTEN pathway59
8.1PIK3CA, APC, ERBB2, KRAS
46
Show member pathways
8.0PIK3CA, ERBB2, KRAS, CASP10, FGFR2
47
Show member pathways
7.8ERBB2, PIK3CA, APC, FGFR2, KRAS
487.8APC, PIK3CA, ERBB2, FGFR2, KRAS
497.7APC, PIK3CA, CASP10, ERBB2, KRAS

Compounds for genes affiliated with Gastric Cancer, Somatic

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Compounds related to Gastric Cancer, Somatic according to GeneCards Suite gene sharing:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
15-methylthioadenosine4410.1FGFR2, ERBB2
2regorafenib50 1110.9FGFR2, KRAS
3cetuximab44 50 1111.8KRAS, ERBB2
4af/ap449.8MUTYH, APC
58-oxoguanine449.7APC, MUTYH
6everolimus44 50 1111.6PIK3CA, ERBB2
7cyclophosphamide44 50 1111.6FGFR2, ERBB2, MUTYH
8suberoylanilide hydroxamic acid449.5IRF1, ERBB2
9o6-methylguanine449.5APC, KRAS
10epinephrine44 24 1111.4FGFR2, ERBB2, APC
11trastuzumab44 50 1111.4ERBB2, PIK3CA, FGFR2
12agar449.3PIK3CA, FGFR2, ERBB2
13adenine44 24 1111.2IRF1, APC, MUTYH
14pertussis449.2APC, FGFR2
15phosphotyrosine449.2FGFR2, PIK3CA, ERBB2
16erlotinib44 50 1111.2PIK3CA, KRAS, ERBB2
17gefitinib44 50 1111.2ERBB2, PIK3CA, KRAS
18imatinib44 50 1111.1ERBB2, KRAS, PIK3CA
19guanine44 24 1111.1APC, FGFR2, ERBB2, MUTYH
20etoposide44 50 60 1112.1IRF1, PIK3CA, ERBB2
21vitamin d449.1FGFR2, KRAS, ERBB2, APC
22doxorubicin44 50 1111.0PIK3CA, ERBB2, FGFR2
23paraffin449.0APC, ERBB2, KRAS, FGFR2
24crcs448.9KRAS, PIK3CA, APC
25tamoxifen44 50 28 1111.9IRF1, ERBB2, FGFR2, PIK3CA
26oligonucleotide448.9APC, FGFR2, IRF1, KRAS
27ly294002448.9KRAS, PIK3CA, ERBB2
285fluorouracil448.9ERBB2, FGFR2, KRAS, PIK3CA
29nitric oxide44 24 1110.8IRF1, KLF6, FGFR2, PIK3CA
30oxygen44 249.8FGFR2, KRAS, MUTYH, IRF1
31arginine448.8ERBB2, FGFR2, IRF1, PIK3CA
32actinomycin d448.8PIK3CA, IRF1, CASP10
33vegf448.8FGFR2, KRAS, PIK3CA, ERBB2
34heparin44 28 24 1111.7ERBB2, FGFR2, APC, PIK3CA
35progesterone44 28 60 24 1112.7APC, PIK3CA, ERBB2, FGFR2
36testosterone44 60 24 1111.7ERBB2, FGFR2, PIK3CA, APC
37wortmannin448.5KRAS, APC, PIK3CA, ERBB2
38phosphoinositide448.5PIK3CA, APC, KRAS
39paclitaxel44 50 1110.5ERBB2, KRAS, FGFR2, PIK3CA, CASP10
40adp44 28 2410.4APC, FGFR2, PIK3CA, KLF6, ERBB2
41h2o2448.3KRAS, FGFR2, ERBB2, PIK3CA, MUTYH
42adenylate448.3KLF6, PIK3CA, APC, IRF1, FGFR2
43rapamycin448.3PIK3CA, ERBB2, FGFR2, APC, KRAS
44retinoic acid44 249.1KRAS, APC, IRF1, PIK3CA, FGFR2
45lipid448.1PIK3CA, APC, IRF1, KRAS, FGFR2
46cisplatin44 50 60 1111.0PIK3CA, MUTYH, CASP10, ERBB2, KRAS, FGFR2
47phosphatidylinositol447.8IRF1, ERBB2, APC, KRAS, FGFR2, PIK3CA
48tyrosine447.8FGFR2, APC, PIK3CA, IRF1, ERBB2, KRAS
49estrogen447.5KLF6, FGFR2, ERBB2, APC, KRAS, IRF1
50serine447.1PIK3CA, APC, IRF1, KRAS, FGFR2, ERBB2

GO Terms for genes affiliated with Gastric Cancer, Somatic

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Cellular components related to Gastric Cancer, Somatic according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00057377.9IRF1, CASP10, ERBB2, KLF6, FGFR2, APC
2plasma membraneGO:00058867.1FGFR2, KRAS, ERBB2, CASP10, APC, PIK3CA

Biological processes related to Gastric Cancer, Somatic according to GeneCards Suite gene sharing:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1regulation of ERK1 and ERK2 cascadeGO:007037210.1ERBB2, FGFR2
2neuromuscular junction developmentGO:00075289.9ERBB2, FGFR2
3regulation of osteoblast differentiationGO:00456679.8APC, FGFR2
4regulation of microtubule-based processGO:00328869.7APC, ERBB2
5positive regulation of epithelial cell proliferationGO:00506799.7ERBB2, FGFR2
6positive regulation of MAP kinase activityGO:00434069.6KRAS, ERBB2
7positive regulation of cell adhesionGO:00457859.6ERBB2, APC
8positive regulation of cell divisionGO:00517819.5FGFR2, APC
9axonogenesisGO:00074099.5FGFR2, APC
10regulation of multicellular organism growthGO:00400149.5FGFR2, PIK3CA
11cytokine-mediated signaling pathwayGO:00192219.4KRAS, KLF6, IRF1
12phosphatidylinositol-mediated signalingGO:00480159.2FGFR2, ERBB2, PIK3CA
13insulin receptor signaling pathwayGO:00082869.0FGFR2, KRAS, PIK3CA
14apoptotic processGO:00069158.9APC, IRF1, CASP10, FGFR2
15fibroblast growth factor receptor signaling pathwayGO:00085438.8FGFR2, KRAS, ERBB2, PIK3CA
16Fc-epsilon receptor signaling pathwayGO:00380958.8PIK3CA, ERBB2, KRAS, FGFR2
17epidermal growth factor receptor signaling pathwayGO:00071738.8FGFR2, KRAS, ERBB2, PIK3CA
18neurotrophin TRK receptor signaling pathwayGO:00480118.7FGFR2, KRAS, ERBB2, PIK3CA
19blood coagulationGO:00075968.4KRAS, IRF1, PIK3CA
20innate immune responseGO:00450878.3PIK3CA, CASP10, ERBB2, KRAS, FGFR2

Molecular functions related to Gastric Cancer, Somatic according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00055156.4FGFR2, KRAS, ERBB2, CASP10, IRF1, MUTYH

Sources for Gastric Cancer, Somatic

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet