MCID: GST060
MIFTS: 47

Gastric Cancer, Somatic malady

Categories: Genetic diseases (common), Gastrointestinal diseases, Cancer diseases

Aliases & Classifications for Gastric Cancer, Somatic

About this section

Aliases & Descriptions for Gastric Cancer, Somatic:

Name: Gastric Cancer, Somatic 52 24 12 35
Malignant Neoplasm of Stomach 68
Gastric Cancer Intestinal 70
Stomach Carcinoma 68
 
Gastric Cancer 70
Stomach Cancer 70
Gasc 70

Characteristics:

HPO:

64
gastric cancer, somatic:
Inheritance: somatic mutation

Classifications:



External Ids:

OMIM52 613659
MeSH39 D013274

Summaries for Gastric Cancer, Somatic

About this section
UniProtKB/Swiss-Prot:70 Gastric cancer: A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease.

MalaCards based summary: Gastric Cancer, Somatic, also known as malignant neoplasm of stomach, is related to familial stomach cancer and gastric cancer risk after h. pylori infection, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Gastric Cancer, Somatic is MUTYH (MutY DNA Glycosylase), and among its related pathways are Angiogenesis (WikiPathways) and G-protein signaling_K-RAS regulation pathway. Affiliated tissues include colon, small intestine and lymph node, and related mouse phenotypes are Increased shRNA abundance and limbs/digits/tail.

OMIM:52 In a review article on the genetic predisposition to gastric cancer, Bevan and Houlston (1999) concluded that several... (613659) more...

Related Diseases for Gastric Cancer, Somatic

About this section

Diseases related to Gastric Cancer, Somatic via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 52)
idRelated DiseaseScoreTop Affiliating Genes
1familial stomach cancer12.3
2gastric cancer risk after h. pylori infection11.0
3htr2a-related altered drug metabolism10.2APC, MUTYH
4hereditary sensory and autonomic neuropathy with deafness and global delay10.2APC, MUTYH
5autoimmune autonomic ganglionopathy10.2APC, MUTYH
6familial hypopituitarism10.2APC, CDH1, MUTYH
7asperger syndrome10.2APC, CDH1, MUTYH
8chronic venous insufficiency10.1APC, KRAS
9hepatocellular carcinoma10.1CDH1, KRAS
10bronchiolitis obliterans with obstructive pulmonary disease10.1CDH1, PIK3CA
11glossopharyngeal motor neuropathy10.1CDH1, ERBB2
12diphallia10.1CDH1, ERBB2
13urethral cancer10.1KRAS, PIK3CA
14melanocytic nevus syndrome, congenital, somatic10.0KRAS, PIK3CA
15mitochondrial neurogastrointestinal encephalopathy disease10.0APC, KRAS, MUTYH
16infantile thalamic degeneration10.0APC, KRAS, MUTYH
17hypogonadotropic hypogonadism 14 with or without anosmia10.0ERBB2, FGFR2
18adult syndrome10.0KRAS, PIK3CA
19gastroesophageal junction adenocarcinoma10.0CDH1, FGFR2, KRAS
20basaloid squamous cell carcinoma10.0CDH1, ERBB2
21hidradenoma10.0APC, KRAS, MUTYH
22precursor t-lymphoblastic lymphoma/leukemia10.0KRAS, PIK3CA
23congenital symblepharon10.0KRAS, MTHFR, MUTYH
24intestinal neuroendocrine benign tumor9.9ERBB2, PIK3CA
25pancreatic cystadenoma9.9FGFR2, KRAS, PIK3CA
26infiltrating angiolipoma9.9ERBB2, PIK3CA
27gastric cancer9.9
28advanced sleep phase syndrome9.9CDH1, KRAS, MTHFR, MUTYH
29progesterone-receptor negative breast cancer9.9ERBB2, FGFR2, PIK3CA
30pearson syndrome9.8CDH1, ERBB2, KRAS
31hnrnpa1-related amyotrophic lateral sclerosis9.8APC, KRAS, MTHFR, MUTYH
32pulmonary fibrosis and/or bone marrow failure, telomere-related, 19.8CDH1, ERBB2, KRAS
33facial dermatosis9.8CDH1, ERBB2, KRAS
34bladder colonic type adenocarcinoma9.8APC, KRAS, MUTYH
35malignant pleural solitary fibrous tumor9.8CDH1, ERBB2, KRAS
36spongiotic dermatitis9.8ERBB2, KRAS, PIK3CA
37vascular hemostatic disease9.8ERBB2, KRAS, PIK3CA
38ideomotor apraxia9.7APC, CDH1, KRAS, MTHFR, MUTYH
39nemaline myopathy 8, autosomal recessive9.7CDH1, ERBB2, KRAS, PIK3CA
40testicular cancer9.7CDH1, ERBB2, FGFR2, KRAS
41dental caries9.7CDH1, ERBB2, KRAS, PIK3CA
42nasal cavity disease9.7CDH1, ERBB2, KRAS, PIK3CA
43trachea squamous cell carcinoma9.7CDH1, ERBB2, KRAS, PIK3CA
44placenta praevia9.7CDH1, ERBB2, KRAS, PIK3CA
45ladd syndrome9.7CDH1, ERBB2, KRAS, PIK3CA
46rhinosporidiosis9.7CDH1, ERBB2, KRAS, PIK3CA
47hypogonadotropic hypogonadism 20 with or without anosmia9.6CDH1, ERBB2, PIK3CA
48nail disorder, nonsyndromic congenital, 3,9.6CDH1, ERBB2, KRAS, PIK3CA
49glycogen storage disease9.6APC, CASP10, CDH1, ERBB2, KRAS
50proctitis9.6CDH1, ERBB2, KRAS, MUTYH, PIK3CA

Comorbidity relations with Gastric Cancer, Somatic via Phenotypic Disease Network (PDN):


Deficiency AnemiaGastric Cancer
NeutropeniaGastric Fundus Cancer
Pylorus CancerHeart Disease
Iron Deficiency AnemiaProtein-Energy Malnutrition
Acute CystitisActive Peptic Ulcer Disease
Intestinal ObstructionStomach Carcinoma in Situ

Graphical network of the top 20 diseases related to Gastric Cancer, Somatic:



Diseases related to gastric cancer, somatic

Symptoms & Phenotypes for Gastric Cancer, Somatic

About this section


Clinical features from OMIM:

613659

Human phenotypes related to Gastric Cancer, Somatic:

 64
id Description HPO Frequency HPO Source Accession
1 stomach cancer64 HP:0012126

UMLS symptoms related to Gastric Cancer, Somatic:


abdominal pain, constipation, diarrhea, dyspepsia, heartburn, icterus, nausea and vomiting, gastrointestinal gas

GenomeRNAi Phenotypes related to Gastric Cancer, Somatic according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00327-A9.2APC, FGFR2, MTHFR, MUTYH

MGI Mouse Phenotypes related to Gastric Cancer, Somatic according to GeneCards Suite gene sharing:

41 (show all 16)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.5APC, ERBB2, FGFR2, KRAS, MTHFR
2MP:00053918.1APC, CTNNBIP1, FGFR2, KRAS, MTHFR, PIK3CA
3MP:00053817.6APC, CDH1, CTNNBIP1, ERBB2, FGFR2, KRAS
4MP:00020067.6APC, CDH1, ERBB2, FGFR2, IRF1, KRAS
5MP:00030127.6APC, CDH1, FGFR2, KRAS, MTHFR, PIK3CA
6MP:00053907.3APC, CTNNBIP1, ERBB2, FGFR2, IRF1, KRAS
7MP:00053807.1APC, CDH1, CTNNBIP1, ERBB2, FGFR2, KLF6
8MP:00053897.0APC, CDH1, ERBB2, FGFR2, KLF6, KRAS
9MP:00053797.0APC, CDH1, ERBB2, FGFR2, IRF1, KLF6
10MP:00036316.8APC, CTNNBIP1, ERBB2, FGFR2, KRAS, MTHFR
11MP:00053766.7APC, CDH1, ERBB2, FGFR2, IRF1, KRAS
12MP:00053856.6APC, CDH1, CTNNBIP1, ERBB2, FGFR2, IRF1
13MP:00053846.3APC, CDH1, CTNNBIP1, ERBB2, FGFR2, IRF1
14MP:00053786.2APC, CDH1, CTNNBIP1, ERBB2, FGFR2, KLF6
15MP:00107716.2APC, CDH1, ERBB2, FGFR2, IRF1, KLF6
16MP:00107685.8APC, CDH1, CTNNBIP1, ERBB2, FGFR2, IRF1

Drugs & Therapeutics for Gastric Cancer, Somatic

About this section

Drugs for Gastric Cancer, Somatic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Rucaparibapproved, investigationalPhase 2, Phase 116283173-50-29931954
Synonyms:
AG-014699
 
AG014699
PF-01367338
rucaparib
2
CarboplatinapprovedPhase 1, Phase 2205041575-94-410339178, 498142, 38904
Synonyms:
(SP-4-2)-diammine[cyclobutane-1,1-dicarboxylato(2-)-kappa(2)O,O']platinum
/h1-3H2,(H,7,8)(H,9,10)
/q
1,1-Cyclobutanedicarboxylate diammine platinum (II)
1,1-Cyclobutanedicarboxylate diammine platinum(II)
2*-1
2*1H2
41575-94-4
70903-55-8
AC-1457
AC1L8I6U
Ambap41575-94-4
BSPBio_003145
C 2538
C2043
C2538_SIGMA
C6H10N2O4Pt
CBDCA
CCRIS 3404
CHEBI:31355
CHEMBL1351
CHEMBL288376
CID10339178
CID2567
CID38904
CID426756
CID498142
CID5352133
CID6398587
CID6603770
Carbopaltin
Carboplatin
Carboplatin (JAN/USP/INN)
Carboplatin (USAN)
Carboplatin [USAN:INN:BAN:JAN]
Carboplatine
Carboplatine [French]
Carboplatino
Carboplatino [Spanish]
Carboplatinum
Carboplatinum [Latin]
Cbdca
Cyclobutane-1,1-dicarboxylate
D01363
DB00958
Diammine(1,1-cyclobutanedicarboxylato)platinum (II)
Diammine(cyclobutane-1,1-dicarboxylato(2-)-O,O')platinum
Diammine-1,1-cyclobutane dicarboxylate platinum II
DivK1c_000892
EINECS 255-446-0
EU-0100230
Ercar
HMS1921J16
HMS2090M05
HMS2092B22
HMS502M14
HSDB 6957
I14-2390
IDI1_000892
IUPAC: Azane
InChI=1/C6H8O4.2H2N.Pt/c7-4(8)6(5(9)10)2-1-3-6
 
JM 8
JM-8
KBio1_000892
KBio2_002009
KBio2_004577
KBio2_007145
KBio3_002645
KBioGR_000713
KBioSS_002009
LS-117689
Lopac-C-2538
Lopac0_000230
MolPort-003-665-501
MolPort-003-845-609
NCGC00015223-01
NCGC00093695-01
NCGC00094961-01
NCGC00094961-02
NCGC00094961-03
NCGC00162099-01
NCGC00162099-02
NCGC00167800-01
NCGC00178242-01
NINDS_000892
NSC 201345
NSC 241240
NSC-241240
NSC201345
NSC241240
Paraplatin
Paraplatin (TN)
Paraplatin, Carboplatin
Paraplatin-AQ
Platinum(+2) Cation
Platinum(II), (1, 1-cyclobutanedicar
Platinum, diammine(1,1-cyclobutanedicarboxylato(2-)-O,O')-, (SP-4-2)
Platinum, {diammine[1,1-cyclobut
S1215_Selleck
SPBio_000716
SPECTRUM1502106
Spectrum2_000898
Spectrum3_001503
Spectrum4_000337
Spectrum5_001094
Spectrum_001529
UNII-BG3F62OND5
azanide
carboplatin
cis -Diammine[1,1-cyclobutane-dicarboxylato] platinum
cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(II)
cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(ii)
cis-Diamine(1,1-cyclobutanedicarboxylato)platinum(II)
cis-Diamine[1,1-cyclobutanedicarboxylato]platinum(II)
cis-Diammine(1,1-cyclobutanedicarboxylato) platinum
cis-Diammine(1,1-cyclobutanedicarboxylato)platinum
cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)
cis-Diammine(cyclobutanedicarboxylato)platinum II
cyclobutane-1,1-dicarboxylic acid
diammine[cyclobutane-1,1-dicarboxylato(2-)-k2O1,O1]platinum
nchembio.573-comp10
nchembio773-comp2
nchembio873-comp3
platinum(2+)
3
OlaparibapprovedPhase 1, Phase 2140763113-22-023725625
Synonyms:
4-(3-{[4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-4-fluorobenzyl)phthalazin-1(2H)-one
4-[(3-{[4-Cyclopropylcarbonyl)piperazin-4-yl]carbonyl}-4-fluorophenyl)methyl]phtalazin-1(2H)-one
4-[3-(4-Cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one
763113-22-0
937799-91-2
AKOS005145764
AZD 2281
AZD-2281
AZD2281
 
Acylpiperazine analogue, 47
CHEMBL521686
EC-000.2324
EN002690
FT-0083489
KU-0059436
KU-59436
Olaparib
Olaparib, KU-0059436, AZD2281, KU0059436, AZD2281
S1060_Selleck
olaparib
4Poly(ADP-ribose) Polymerase InhibitorsPhase 2, Phase 1340
5ImmunoglobulinsPhase 1, Phase 26394
6Antibodies, MonoclonalPhase 1, Phase 24039
7AntibodiesPhase 1, Phase 26394

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Study of Rucaparib in Patients With Pancreatic Cancer and a Known Deleterious BRCA MutationCompletedNCT02042378Phase 2
2Ascending Doses of AZD6738 in Combination With Chemotherapy and/or Novel Anti Cancer AgentsRecruitingNCT02264678Phase 1, Phase 2
3A Study of Oral Rucaparib in Patients With a Solid Tumor (Phase I) or With gBRCA Mutation Ovarian Cancer (Phase II)Active, not recruitingNCT01482715Phase 1, Phase 2
4Phenotyping of Small Bowel AdenocarcinomaActive, not recruitingNCT02976090

Search NIH Clinical Center for Gastric Cancer, Somatic

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Gastric Cancer, Somatic cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Gastric Cancer, Somatic:
Tumor infiltrating lymphocytes (TILs) for solid tumors
Embryonic/Adult Cultured Cells Related to Gastric Cancer, Somatic:
Tumor infiltrating lymphocytes, PMIDs: 24329789, 19342963, 23904171, 21498393, 22996367, 19304471, 22555974, 15800326, 23650429, 21325070, 24218514, 8170938, 12242449

Genetic Tests for Gastric Cancer, Somatic

About this section

Genetic tests related to Gastric Cancer, Somatic:

id Genetic test Affiliating Genes
1 Gastric Cancer, Somatic24 KRAS, FGFR2, PIK3CA

Anatomical Context for Gastric Cancer, Somatic

About this section

MalaCards organs/tissues related to Gastric Cancer, Somatic:

36
Colon, Small intestine, Lymph node

Publications for Gastric Cancer, Somatic

About this section

Variations for Gastric Cancer, Somatic

About this section

UniProtKB/Swiss-Prot genetic disease variations for Gastric Cancer, Somatic:

70 (show all 19)
id Symbol AA change Variation ID SNP ID
1APCp.Gly817CysVAR_005035
2APCp.Ile880ThrVAR_005036
3APCp.Asn942AspVAR_005039
4APCp.Gly1120GluVAR_005042rs28933379
5APCp.Arg1171HisVAR_005043rs372481703
6APCp.Phe1197SerVAR_005045
7APCp.Ile1259ThrVAR_005046
8APCp.Gly1312GluVAR_005050
9APCp.Val1326AlaVAR_005052
10CASP10p.Met147ThrVAR_037428rs121909776
11IRF1p.Met8LeuVAR_065134rs121912469
12IRF1p.Trp11ArgVAR_065135rs121912470
13KRASp.Gly12ValVAR_006840rs121913529
14KRASp.Gly12AspVAR_016026rs121913529
15KRASp.Gly12SerVAR_016028rs121913530
16KRASp.Gly13AspVAR_016029rs112445441
17KRASp.Ala59ThrVAR_016030rs121913528
18KRASp.Lys5AsnVAR_064849rs104894361
19MUTYHp.Pro402SerVAR_026049rs121908382

Clinvar genetic disease variations for Gastric Cancer, Somatic:

5 (show all 23)
id Gene Variation Type Significance SNP ID Assembly Location
1KRASNM_ 004985.4(KRAS): c.35G> A (p.Gly12Asp)SNVPathogenic/ Likely pathogenicrs121913529GRCh37Chr 12, 25398284: 25398284
2KRASNM_ 033360.3(KRAS): c.34G> A (p.Gly12Ser)SNVPathogenicrs121913530GRCh37Chr 12, 25398285: 25398285
3FGFR2NM_ 000141.4(FGFR2): c.799T> C (p.Ser267Pro)SNVPathogenicrs121918505GRCh37Chr 10, 123279633: 123279633
4PIK3CANM_ 006218.3(PIK3CA): c.3140A> G (p.His1047Arg)SNVPathogenic/ Likely pathogenicrs121913279GRCh37Chr 3, 178952085: 178952085
5PIK3CANM_ 006218.3(PIK3CA): c.1633G> A (p.Glu545Lys)SNVPathogenic/ Likely pathogenicrs104886003GRCh37Chr 3, 178936091: 178936091
6PIK3CANM_ 006218.3(PIK3CA): c.3203dupA (p.Asn1068Lysfs)duplicationPathogenicrs587776802GRCh37Chr 3, 178952148: 178952148
7ERBB2NM_ 001005862.2(ERBB2): c.2236G> A (p.Gly746Ser)SNVPathogenic/ Likely pathogenicrs28933369GRCh37Chr 17, 37880997: 37880997
8IRF1NM_ 002198.2(IRF1): c.22A> T (p.Met8Leu)SNVPathogenicrs121912469GRCh37Chr 5, 131825149: 131825149
9MUTYHNM_ 001128425.1(MUTYH): c.1213C> T (p.Pro405Ser)SNV, HaplotypePathogenicrs121908382GRCh37Chr 1, 45797202: 45797202
10MTHFRNM_ 005957.4(MTHFR): c.665C> T (p.Ala222Val)SNVdrug responsers1801133GRCh37Chr 1, 11856378: 11856378
11CTNNB1NM_ 001904.3(CTNNB1): c.110C> A (p.Ser37Tyr)SNVPathogenic/ Likely pathogenicrs121913403GRCh37Chr 3, 41266113: 41266113
12ERBB3NM_ 001982.3(ERBB3): c.850G> A (p.Gly284Arg)SNVLikely pathogenicrs1057519803GRCh37Chr 12, 56481922: 56481922
13NRASNM_ 002524.4(NRAS): c.37G> A (p.Gly13Ser)SNVLikely pathogenicrs121434595GRCh37Chr 1, 115258745: 115258745
14CTNNB1NM_ 001904.3(CTNNB1): c.109T> C (p.Ser37Pro)SNVLikely pathogenicrs121913228GRCh37Chr 3, 41266112: 41266112
15CTNNB1NM_ 001904.3(CTNNB1): c.118A> G (p.Thr40Ala)SNVLikely pathogenicrs1057519836GRCh37Chr 3, 41266121: 41266121
16MUTYHNM_ 001128425.1(MUTYH): c.1228_ 1229dupGA (p.Pro411Serfs)duplicationLikely pathogenicGRCh37Chr 1, 45797186: 45797187
17MUTYHNM_ 001128425.1(MUTYH): c.1187G> A (p.Gly396Asp)SNVPathogenicrs36053993GRCh37Chr 1, 45797228: 45797228
18MUTYHNM_ 001128425.1(MUTYH): c.1241A> G (p.Gln414Arg)SNVPathogenicrs121908383GRCh37Chr 1, 45797174: 45797174
19KLF6NM_ 001300.5(KLF6): c.465C> A (p.Ser155Arg)SNVPathogenicrs121909144GRCh37Chr 10, 3824044: 3824044
20CASP10NM_ 032977.3(CASP10): c.769C> T (p.Gln257Ter)SNVPathogenicrs121909775GRCh37Chr 2, 202070652: 202070652
21CASP10NM_ 032977.3(CASP10): c.440T> C (p.Met147Thr)SNVPathogenicrs121909776GRCh37Chr 2, 202052521: 202052521
22APCNM_ 000038.5(APC): c.3359G> A (p.Gly1120Glu)SNVPathogenicrs28933379GRCh37Chr 5, 112174650: 112174650
23APCNM_ 000038.5(APC): c.3199C> T (p.Gln1067Ter)SNVPathogenicrs137854571GRCh37Chr 5, 112174490: 112174490

Cosmic variations for Gastric Cancer, Somatic:

8 (show top 50)    (show all 778)
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1COSM20525STK26stomach,NS,carcinoma,adenocarcinomac.444C>Gp.A148A7
2COSM20551TRRAPstomach,NS,carcinoma,adenocarcinomac.5117G>Ap.R1706H7
3COSM1579018CDC42stomach,NS,carcinoma,adenocarcinomac.178+7A>Gp.?7
4COSM44091TP53stomach,NS,carcinoma,adenocarcinomac.746G>Ap.R249K7
5COSM44151TP53stomach,NS,carcinoma,adenocarcinomac.535C>Ap.H179N7
6COSM5279PTENstomach,NS,carcinoma,adenocarcinomac.610C>Ap.P204T7
7COSM760PIK3CAstomach,NS,carcinoma,adenocarcinomac.1624G>Ap.E542K7
8COSM4062177CDH1stomach,NS,carcinoma,adenocarcinomac.569A>Gp.Y190C7
9COSM767PIK3CAstomach,NS,carcinoma,adenocarcinomac.1637A>Cp.Q546P7
10COSM10648TP53stomach,NS,carcinoma,adenocarcinomac.524G>Ap.R175H7
11COSM5576263CDH1stomach,NS,carcinoma,adenocarcinomac.466T>Ap.W156R7
12COSM1716270AXIN1stomach,NS,carcinoma,adenocarcinomac.1591C>Ap.H531N7
13COSM10704TP53stomach,NS,carcinoma,adenocarcinomac.844C>Tp.R282W7
14COSM10656TP53stomach,NS,carcinoma,adenocarcinomac.742C>Tp.R248W7
15COSM5575863KMT2Cstomach,NS,carcinoma,adenocarcinomac.13602G>Cp.Q4534H7
16COSM5576251LRP1Bstomach,NS,carcinoma,adenocarcinomac.8269+2T>Cp.?7
17COSM10705TP53stomach,NS,carcinoma,adenocarcinomac.586C>Tp.R196*7
18COSM5576102ZNF521stomach,NS,carcinoma,adenocarcinomac.443G>Ap.C148Y7
19COSM5670CTNNB1stomach,NS,carcinoma,adenocarcinomac.101G>Tp.G34V7
20COSM5576226RETstomach,NS,carcinoma,adenocarcinomac.898G>Ap.D300N7
21COSM5576053NSD2stomach,NS,carcinoma,adenocarcinomac.3235G>Ap.A1079T7
22COSM10663TP53stomach,NS,carcinoma,adenocarcinomac.916C>Tp.R306*7
23COSM133015ARID1Astomach,NS,carcinoma,adenocarcinomac.5359G>Tp.E1787*7
24COSM266035ARID2stomach,NS,carcinoma,adenocarcinomac.925A>Gp.N309D7
25COSM43826TP53stomach,NS,carcinoma,adenocarcinomac.706T>Ap.Y236N7
26COSM521KRASstomach,NS,carcinoma,adenocarcinomac.35G>Ap.G12D7
27COSM5576192DICER1stomach,NS,carcinoma,adenocarcinomac.322C>Gp.Q108E7
28COSM5575994NUP214stomach,NS,carcinoma,adenocarcinomac.6140G>Tp.G2047V7
29COSM763PIK3CAstomach,NS,carcinoma,adenocarcinomac.1633G>Ap.E545K7
30COSM483HRASstomach,NS,carcinoma,adenocarcinomac.35G>Tp.G12V7
31COSM5575902PTPN11stomach,NS,carcinoma,adenocarcinomac.222G>Cp.L74F7
32COSM14062ERBB2stomach,NS,carcinoma,adenocarcinomac.2329G>Tp.V777L7
33COSM5575798MYH9stomach,NS,carcinoma,adenocarcinomac.5677C>Tp.R1893C7
34COSM11089TP53stomach,NS,carcinoma,adenocarcinomac.584T>Cp.I195T7
35COSM10709TP53stomach,NS,carcinoma,adenocarcinomac.722C>Gp.S241C7
36COSM685ERBB2stomach,NS,carcinoma,adenocarcinomac.2326G>Ap.G776S7
37COSM20569EPHA2stomach,NS,carcinoma,adenocarcinomac.2329G>Ap.G777S7
38COSM20537MLKLstomach,NS,carcinoma,adenocarcinomac.872T>Cp.L291P7
39COSM20558TGFBR2stomach,NS,carcinoma,adenocarcinomac.181T>Cp.C61R7
40COSM20550TRRAPstomach,NS,carcinoma,adenocarcinomac.477A>Gp.K159K7
41COSM20528TNK2stomach,NS,carcinoma,adenocarcinomac.1227G>Ap.M409I7
42COSM21289TEX14stomach,NS,carcinoma,adenocarcinomac.961G>Ap.E321K7
43COSM21278MLKLstomach,NS,carcinoma,adenocarcinomac.1192T>Ap.F398I7
44COSM5575620ADGRL3stomach,NS,carcinoma,adenocarcinomac.1023C>Ap.Y341*7
45COSM45620TP53stomach,NS,carcinoma,adenocarcinomac.704A>Cp.N235T7
46COSM5575913ERCC4stomach,NS,carcinoma,adenocarcinomac.2026G>Tp.E676*7
47COSM5575897ROS1stomach,NS,carcinoma,adenocarcinomac.89T>Ap.L30*7
48COSM14065ERBB2stomach,NS,carcinoma,adenocarcinomac.2524G>Ap.V842I7
49COSM5576132SETD2stomach,NS,carcinoma,adenocarcinomac.2168C>Ap.P723Q7
50COSM10735TP53stomach,NS,carcinoma,adenocarcinomac.638G>Ap.R213Q7

Expression for genes affiliated with Gastric Cancer, Somatic

About this section
Search GEO for disease gene expression data for Gastric Cancer, Somatic.

Pathways for genes affiliated with Gastric Cancer, Somatic

About this section

Pathways related to Gastric Cancer, Somatic according to GeneCards Suite gene sharing:

(show all 38)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.8FGFR2, PIK3CA
29.6KRAS, PIK3CA
39.6KRAS, PIK3CA
49.4IRF1, KRAS, PIK3CA
5
Show member pathways
9.3CASP10, KRAS, PIK3CA
6
Show member pathways
9.3FGFR2, KRAS, PIK3CA
79.3CDH1, PIK3CA
89.3CDH1, PIK3CA
99.2APC, ERBB2, KRAS
109.2CDH1, KRAS
11
Show member pathways
9.2ERBB2, FGFR2, KRAS
12
Show member pathways
9.1ERBB2, KRAS, PIK3CA
13
Show member pathways
9.1ERBB2, KRAS, PIK3CA
14
Show member pathways
9.1ERBB2, KRAS, PIK3CA
15
Show member pathways
9.0CASP10, IRF1, KRAS, PIK3CA
169.0APC, CASP10, CDH1
17
Show member pathways
9.0APC, FGFR2, KRAS, PIK3CA
189.0APC, FGFR2, KRAS, PIK3CA
19
Show member pathways
9.0APC, CDH1, PIK3CA
208.9CDH1, FGFR2, PIK3CA
218.9APC, CDH1, KRAS
228.9APC, CDH1, KRAS
23
Show member pathways
8.8ERBB2, IRF1, KRAS, PIK3CA
248.8APC, CDH1, CTNNBIP1
258.8APC, ERBB2, KRAS, PIK3CA
268.8APC, ERBB2, KRAS, PIK3CA
278.8ERBB2, FGFR2, KRAS, PIK3CA
28
Show member pathways
8.8ERBB2, FGFR2, KRAS, PIK3CA
298.8CDH1, ERBB2, PIK3CA
30
Show member pathways
8.7CDH1, ERBB2, KRAS
31
Show member pathways
8.5APC, ERBB2, FGFR2, KRAS, PIK3CA
32
Show member pathways
8.5CDH1, FGFR2, KRAS, PIK3CA
33
Show member pathways
8.5CASP10, ERBB2, FGFR2, KRAS, PIK3CA
34
Show member pathways
8.0APC, CDH1, ERBB2, KRAS, PIK3CA
35
Show member pathways
8.0APC, CDH1, ERBB2, KRAS, PIK3CA
36
Show member pathways
8.0CASP10, CDH1, ERBB2, KRAS, PIK3CA
37
Show member pathways
7.7APC, CDH1, ERBB2, FGFR2, KRAS, PIK3CA
387.7APC, CDH1, ERBB2, FGFR2, KRAS, PIK3CA

GO Terms for genes affiliated with Gastric Cancer, Somatic

About this section

Cellular components related to Gastric Cancer, Somatic according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1beta-catenin destruction complexGO:003087710.4APC, CTNNBIP1
2catenin complexGO:001634210.1APC, CDH1
3lamellipodiumGO:00300279.0APC, CDH1, PIK3CA
4cytosolGO:00058297.2APC, CASP10, CTNNBIP1, ERBB2, IRF1, KLF6

Biological processes related to Gastric Cancer, Somatic according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1regulation of multicellular organism growthGO:004001410.3FGFR2, PIK3CA
2regulation of microtubule-based processGO:003288610.2APC, ERBB2
3regulation of ERK1 and ERK2 cascadeGO:007037210.2ERBB2, FGFR2
4phosphatidylinositol phosphorylationGO:00468549.8ERBB2, FGFR2, PIK3CA
5phosphatidylinositol-mediated signalingGO:00480159.8ERBB2, FGFR2, PIK3CA
6ERBB2 signaling pathwayGO:00381289.8ERBB2, KRAS, PIK3CA
7regulation of phosphatidylinositol 3-kinase signalingGO:00140669.2ERBB2, FGFR2, PIK3CA

Molecular functions related to Gastric Cancer, Somatic according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1gamma-catenin bindingGO:00452959.8APC, CDH1
2beta-catenin bindingGO:00080139.3APC, CDH1, CTNNBIP1
3phosphatidylinositol-4,5-bisphosphate 3-kinase activityGO:00469349.2ERBB2, FGFR2, PIK3CA

Sources for Gastric Cancer, Somatic

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet