MCID: GST060
MIFTS: 52

Gastric Cancer, Somatic malady

Gastrointestinal diseases, Cancer diseases categories

Summaries for Gastric Cancer, Somatic

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46OMIM, 32MalaCards
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MalaCards: Gastric Cancer, Somatic, also known as malignant neoplasm of stomach, is related to hereditary diffuse gastric cancer and colorectal cancer. An important gene associated with Gastric Cancer, Somatic is CASP10 (caspase 10, apoptosis-related cysteine peptidase), and among its related pathways are Nanog in Mammalian ESC Pluripotency and Angiogenesis. The compounds adriamycin and af/ap have been mentioned in the context of this disorder. Affiliated tissues include colon, and related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

Description from OMIM:46 613659,137215

Aliases & Classifications for Gastric Cancer, Somatic

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46OMIM, 48Orphanet, 60UMLS, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Gastrointestinal diseases


Characteristics (Orphanet epidemiological data):

48
stomach cancer:
Inheritance: Multigenic/multifactorial,Sporadic; Prevalence: 1-5/10000; Age of onset: Adulthood


Aliases & Descriptions:

gastric cancer, somatic 46
malignant neoplasm of stomach 60
stomach cancer 48
gastric cancer 48


External Ids:

SNOMED-CT via Orphanet57 363349007
OMIM46 613659
ICD10 via Orphanet26 C16

Related Diseases for Gastric Cancer, Somatic

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17GeneCards, 18GeneDecks
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Diseases related to Gastric Cancer, Somatic via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 291)
idRelated DiseaseScoreTop Affiliating Genes
1hereditary diffuse gastric cancer31.3CDH1
2colorectal cancer30.9KLF6, APC, PIK3CA, MUTYH, CDH1, FGFR2
3esophageal cancer30.9CDH1
4stomach cancer30.8CASP10, IRF1, APC, PIK3CA, MUTYH, CDH1
5gastric adenocarcinoma30.8APC, PIK3CA, CDH1, KRAS, ERBB2
6breast cancer30.8KLF6, CASP10, IRF1, APC, PIK3CA, CDH1
7adenocarcinoma30.8KLF6, IRF1, APC, PIK3CA, CDH1, FGFR2
8colon cancer30.7APC, PIK3CA, CDH1, KRAS
9pancreatitis30.6KRAS
10pancreatic cancer30.6PIK3CA, CDH1, FGFR2, KRAS, ERBB2
11lung cancer30.6PIK3CA, CDH1, KRAS, ERBB2
12hepatitis30.5IRF1, KRAS
13prostate cancer30.5KLF6, APC, PIK3CA, CDH1, FGFR2, KRAS
14leukemia30.4CASP10, IRF1, PIK3CA, FGFR2, KRAS
15melanoma30.4CASP10, IRF1, PIK3CA, CDH1, FGFR2, KRAS
16brain cancer30.4KLF6, APC, PIK3CA
17thyroid cancer30.2APC, PIK3CA, CDH1
18adenoma30.2KRAS, CDH1, MUTYH, APC
19tubular adenocarcinoma30.1ERBB2, CDH1
20squamous cell carcinoma30.1IRF1, APC, PIK3CA, CDH1, FGFR2, KRAS
21lynch syndrome30.0APC, MUTYH, KRAS
22kidney cancer30.0IRF1, PIK3CA, CDH1, FGFR2
23familial adenomatous polyposis30.0IRF1, APC, MUTYH, CDH1, KRAS
24retinoblastoma30.0KLF6, IRF1, APC, PIK3CA, FGFR2, KRAS
25hepatocellular carcinoma30.0KLF6, IRF1, APC, PIK3CA, MUTYH, CDH1
26choriocarcinoma29.8FGFR2
27sarcoma29.8KRAS
28herpes simplex29.8FGFR2, IRF1
29hepatitis c29.8KRAS, IRF1
30gallbladder cancer29.8APC, KRAS
31acute leukemia29.8IRF1, PIK3CA, KRAS
32cervical cancer29.8ERBB2, PIK3CA, IRF1
33inflammatory breast carcinoma29.8ERBB2, CDH1
34transitional cell carcinoma29.8ERBB2, FGFR2, CDH1
35cholangiocarcinoma29.8ERBB2, KRAS, CDH1, PIK3CA
36ovarian cancer29.8IRF1, PIK3CA, CDH1, KRAS, ERBB2
37lung adenocarcinoma29.8KLF6, PIK3CA, CDH1, KRAS, ERBB2
38lymph node cancer10.9
39peritonitis10.9
40gastritis10.9
41vascular cancer10.9
42gastric ulcer10.8
43atrophic gastritis10.7
44cell type cancer10.7
45esophagitis10.6
46duodenitis10.6
47peptic ulcer10.6
48duodenal ulcer10.6
49stomach disease10.5
50gastric lymphoma10.5

Graphical network of the top 20 diseases related to Gastric Cancer, Somatic:



Diseases related to gastric cancer, somatic

Clinical Features for Gastric Cancer, Somatic

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46OMIM
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Clinical features from OMIM:

613659,137215

Drugs & Therapeutics for Gastric Cancer, Somatic

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Gastric Cancer, Somatic

Drug clinical trials:

Search ClinicalTrials for Gastric Cancer, Somatic

Search NIH Clinical Center for Gastric Cancer, Somatic

Search CenterWatch for Gastric Cancer, Somatic

Genetic Tests for Gastric Cancer, Somatic

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Anatomical Context for Gastric Cancer, Somatic

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32MalaCards
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MalaCards organs/tissues related to Gastric Cancer, Somatic:

32
Colon

Animal Models for Gastric Cancer, Somatic or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Gastric Cancer, Somatic:

36 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.0IRF1, PIK3CA, MUTYH, FGFR2
2MP:00053799.0PIK3CA, FGFR2, KRAS
3MP:00053697.6ERBB2, KRAS, FGFR2, PIK3CA, APC
4MP:00107717.3KLF6, IRF1, APC, PIK3CA, CDH1, FGFR2
5MP:00053817.3APC, CDH1, FGFR2, KRAS, ERBB2
6MP:00028737.3IRF1, APC, CDH1, FGFR2, KRAS, ERBB2
7MP:00053897.2APC, PIK3CA, CDH1, FGFR2, KRAS, ERBB2
8MP:00053806.9KLF6, APC, PIK3CA, CDH1, FGFR2, KRAS
9MP:00020066.7ERBB2, IRF1, APC, PIK3CA, MUTYH, CDH1
10MP:00053786.6KLF6, APC, PIK3CA, CDH1, FGFR2, KRAS
11MP:00053856.6KLF6, IRF1, APC, PIK3CA, CDH1, FGFR2
12MP:00053846.3KLF6, IRF1, APC, PIK3CA, MUTYH, CDH1
13MP:00107686.2KLF6, IRF1, APC, PIK3CA, MUTYH, CDH1

Publications for Gastric Cancer, Somatic

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Genetic Variations for Gastric Cancer, Somatic

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Sources:
62UniProtKB/Swiss-Prot
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Genetic disease variations for Gastric Cancer, Somatic:

62 (show all 23)
id Symbol AA change Variation ID SNP ID
1APCp.Gly817CysVAR_005035
2APCp.Ile880ThrVAR_005036
3APCp.Asn942AspVAR_005039
4APCp.Gly1120GluVAR_005042rs28933379
5APCp.Arg1171HisVAR_005043
6APCp.Phe1197SerVAR_005045
7APCp.Ile1259ThrVAR_005046
8APCp.Gly1312GluVAR_005050
9APCp.Val1326AlaVAR_005052
10CASP10p.Met147ThrVAR_037428rs121909776
11CDH1p.Asp244GlyVAR_008712
12CDH1p.Val487AlaVAR_008713
13CDH1p.Val832MetVAR_023358rs35572355
14IRF1p.Met8LeuVAR_065134
15IRF1p.Trp11ArgVAR_065135
16KRASp.Gly12ValVAR_006840
17KRASp.Gly12AspVAR_016026
18KRASp.Gly12SerVAR_016028
19KRASp.Gly13AspVAR_016029
20KRASp.Ala59ThrVAR_016030
21KRASp.Lys5AsnVAR_064849
22MUTYHp.Pro402SerVAR_026049
23MUTYHp.Gln411ArgVAR_026050

Expression for genes affiliated with Gastric Cancer, Somatic

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gastric Cancer, Somatic

Search GEO for disease gene expression data for Gastric Cancer, Somatic.

Pathways for genes affiliated with Gastric Cancer, Somatic

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Sources:
51QIAGEN, 37NCBI BioSystems Database, 49PharmGKB, 59Tocris Bioscience, 29KEGG, 12EMD Millipore, 53Reactome, 55SinoBiological, 52R&D Systems
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Pathways related to Gastric Cancer, Somatic according to GeneCards/GeneDecks:

(show all 44)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.0APC
29.6PIK3CA, FGFR2
39.5CDH1, PIK3CA
49.5CDH1, PIK3CA
59.5CDH1, PIK3CA
69.4ERBB2, PIK3CA
7
Hide members
9.3PIK3CA, FGFR2, CASP10
8
Hide members
9.2KRAS, FGFR2
99.2KRAS, PIK3CA
109.2PIK3CA, KRAS
119.1CASP10, CDH1, APC
129.1CDH1, KRAS
139.1CDH1, PIK3CA, FGFR2
14
Hide members
9.0ERBB2, KRAS
159.0ERBB2, CDH1, CASP10
16
Hide members
9.0CDH1, APC, PIK3CA
17
Hide members
8.9CASP10, PIK3CA, KRAS
18
Hide members
8.9PIK3CA, IRF1, KRAS
198.9PIK3CA, IRF1, KRAS
208.9PIK3CA, CDH1, ERBB2
21
Hide members
8.9PIK3CA, CDH1, ERBB2
22
Hide members
8.8FGFR2, PIK3CA, KRAS
23
Hide members
8.8PIK3CA, FGFR2, KRAS
24
Hide members
8.6ERBB2, FGFR2, KRAS
258.6ERBB2, KRAS, FGFR2
26
Hide members
8.6CASP10, CDH1, FGFR2, ERBB2
278.6ERBB2, PIK3CA, KRAS
28
Hide members
8.6KRAS, ERBB2, PIK3CA
29
Hide members
8.6ERBB2, PIK3CA, KRAS
30
Hide members
8.5FGFR2, CDH1, PIK3CA, IRF1, CASP10
31
Hide members
8.3APC, PIK3CA, FGFR2, KRAS
32
Development Prolactin receptor signaling
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8.3KRAS, PIK3CA, IRF1, ERBB2
33
Hide members
8.2FGFR2, KRAS, PIK3CA, ERBB2
348.2PIK3CA, ERBB2, FGFR2, KRAS
35
Hide members
8.2ERBB2, PIK3CA, KRAS, FGFR2
36
Hide members
8.2ERBB2, KRAS, FGFR2, PIK3CA
37
Hide members
8.1ERBB2, APC, CASP10, CDH1, FGFR2
388.1ERBB2, KRAS, PIK3CA, APC
39
Hide members
7.9ERBB2, FGFR2, PIK3CA, CASP10, KRAS
407.8ERBB2, CASP10, KRAS, APC, PIK3CA
41
Hide members
7.5KRAS, CDH1, PIK3CA, ERBB2, APC
42
Hide members
7.5APC, PIK3CA, ERBB2, CDH1, KRAS
437.1KRAS, APC, PIK3CA, CDH1, FGFR2, ERBB2
44
Hide members
7.1FGFR2, APC, PIK3CA, ERBB2, KRAS, CDH1

Compounds for genes affiliated with Gastric Cancer, Somatic

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Gastric Cancer, Somatic according to GeneCards/GeneDecks:

(show top 50)    (show all 59)
idCompoundScoreTop Affiliating Genes
1adriamycin4410.4IRF1
2af/ap4410.0MUTYH, APC
3pki-166449.6ERBB2, CDH1
4exisulind449.6CDH1, APC
58-oxoguanine449.6MUTYH, APC
6everolimus49 44 1111.6PIK3CA, ERBB2
7sodium bisulfite449.6CDH1, APC
8guanine44 11 2411.5ERBB2, FGFR2, MUTYH
9adp44 28 2411.5KLF6, APC, FGFR2
10suberoylanilide hydroxamic acid449.4IRF1, CDH1, ERBB2
11trastuzumab44 49 1111.3ERBB2, FGFR2, PIK3CA
12adenine44 11 2411.2CDH1, MUTYH, APC, IRF1
13celecoxib44 59 28 49 11 2414.2APC, CDH1, ERBB2
14docetaxel44 49 59 1112.1ERBB2, CDH1, PIK3CA
15o6-methylguanine449.0APC, CDH1, KRAS
165-aza-2deoxycytidine448.9APC, CDH1, FGFR2
17etoposide44 49 59 1111.9ERBB2, CDH1, PIK3CA, IRF1
18curcumin448.9ERBB2, CDH1, APC
19agar448.8ERBB2, FGFR2, CDH1, PIK3CA
20irinotecan44 49 1110.8CDH1, KRAS, ERBB2
21phosphotyrosine448.8PIK3CA, CDH1, FGFR2, ERBB2
22folate448.8APC, CDH1, ERBB2
23doxorubicin44 49 1110.8PIK3CA, CDH1, FGFR2, ERBB2
24p002448.8CDH1, KRAS, ERBB2
25genistein44 28 59 2 11 2413.7ERBB2, FGFR2, CDH1, PIK3CA
26imatinib44 49 1110.7PIK3CA, KRAS, ERBB2
27crcs448.6APC, PIK3CA, CDH1, KRAS
28tamoxifen44 49 28 1111.6IRF1, PIK3CA, CDH1, FGFR2, ERBB2
29erlotinib44 49 1110.5PIK3CA, CDH1, KRAS, ERBB2
30gefitinib44 49 1110.5ERBB2, KRAS, CDH1, PIK3CA
31arginine448.5IRF1, PIK3CA, CDH1, FGFR2, ERBB2
32ly294002448.4ERBB2, KRAS, CDH1, PIK3CA
33heparin44 28 11 2411.3APC, PIK3CA, CDH1, FGFR2, ERBB2
34progesterone44 59 28 11 2412.3APC, PIK3CA, CDH1, FGFR2, ERBB2
35testosterone44 59 11 2411.3APC, PIK3CA, CDH1, FGFR2, ERBB2
36adenylate448.3KLF6, IRF1, APC, PIK3CA, CDH1, FGFR2
37h2o2448.2ERBB2, KRAS, FGFR2, MUTYH, PIK3CA
38paclitaxel44 49 1110.1PIK3CA, CDH1, FGFR2, KRAS, ERBB2
395fluorouracil448.1PIK3CA, CDH1, FGFR2, KRAS, ERBB2
40vitamin d448.0APC, CDH1, FGFR2, KRAS, ERBB2
41paraffin448.0APC, CDH1, FGFR2, KRAS, ERBB2
42vegf448.0ERBB2, KRAS, FGFR2, CDH1, PIK3CA
43wortmannin448.0ERBB2, KRAS, CDH1, PIK3CA, APC
44retinoic acid44 248.8IRF1, APC, PIK3CA, CDH1, FGFR2, KRAS
45cisplatin44 49 59 1110.8CASP10, PIK3CA, CDH1, FGFR2, KRAS, ERBB2
46lipid447.6IRF1, APC, PIK3CA, FGFR2, KRAS
47rapamycin447.6APC, PIK3CA, CDH1, FGFR2, KRAS, ERBB2
48phosphatidylinositol447.2IRF1, APC, PIK3CA, CDH1, FGFR2, KRAS
49tyrosine447.2IRF1, APC, PIK3CA, CDH1, FGFR2, KRAS
50serine446.6ERBB2, KLF6, CASP10, IRF1, APC, PIK3CA

GO Terms for genes affiliated with Gastric Cancer, Somatic

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16Gene Ontology
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Cellular components related to Gastric Cancer, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell-cell adherens junctionGO:0059139.4CDH1, APC
2plasma membraneGO:0058866.5ERBB2, KRAS, FGFR2, CDH1, PIK3CA, APC

Biological processes related to Gastric Cancer, Somatic according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1regulation of osteoblast differentiationGO:0456679.8FGFR2, APC
2regulation of multicellular organism growthGO:0400149.7FGFR2, PIK3CA
3regulation of ERK1 and ERK2 cascadeGO:0703729.6ERBB2, FGFR2
4regulation of microtubule-based processGO:0328869.5APC, ERBB2
5tight junction assemblyGO:0708309.4CDH1, APC
6neuromuscular junction developmentGO:0075289.3FGFR2, ERBB2
7phosphatidylinositol-mediated signalingGO:0480159.1ERBB2, FGFR2, PIK3CA
8positive regulation of cell adhesionGO:0457859.0ERBB2, APC
9cytokine-mediated signaling pathwayGO:0192219.0KRAS, IRF1, KLF6
10insulin receptor signaling pathwayGO:0082868.9PIK3CA, FGFR2, KRAS
11apoptotic processGO:0069158.7FGFR2, CDH1, APC, IRF1, CASP10
12fibroblast growth factor receptor signaling pathwayGO:0085438.5ERBB2, KRAS, FGFR2, PIK3CA
13Fc-epsilon receptor signaling pathwayGO:0380958.5PIK3CA, FGFR2, KRAS, ERBB2
14epidermal growth factor receptor signaling pathwayGO:0071738.4ERBB2, KRAS, FGFR2, PIK3CA
15neurotrophin TRK receptor signaling pathwayGO:0480118.4PIK3CA, FGFR2, KRAS, ERBB2
16innate immune responseGO:0450878.1CASP10, PIK3CA, FGFR2, KRAS, ERBB2

Molecular functions related to Gastric Cancer, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1gamma-catenin bindingGO:0452959.4CDH1, APC
2protein bindingGO:0055155.9ERBB2, CASP10, IRF1, APC, PIK3CA, MUTYH

Products for genes affiliated with Gastric Cancer, Somatic

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  • Antibodies
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Sources for Gastric Cancer, Somatic

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet