MCID: GST060
MIFTS: 48

Gastric Cancer, Somatic malady

Genetic diseases (common), Cancer diseases, Gastrointestinal diseases categories

Aliases & Classifications for Gastric Cancer, Somatic

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Aliases & Descriptions for Gastric Cancer, Somatic:

Name: Gastric Cancer, Somatic 49 11 22
Malignant Neoplasm of Stomach 65
Gastric Cancer Intestinal 67
Stomach Carcinoma 65
 
Stomach Cancer 67
Gastric Cancer 67
Gasc 67


Classifications:



External Ids:

OMIM49 613659
ICD1027 C16
MeSH36 D013274

Summaries for Gastric Cancer, Somatic

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UniProtKB/Swiss-Prot:67 Gastric cancer: A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease.

MalaCards based summary: Gastric Cancer, Somatic, also known as malignant neoplasm of stomach, is related to gastrointestinal system cancer and stomach disease, and has symptoms including somatic mutationand stomach cancer. An important gene associated with Gastric Cancer, Somatic is APC (Adenomatous Polyposis Coli), and among its related pathways are Atypical NF-kappaB pathway and E-cadherin signaling in keratinocytes. Affiliated tissues include colon, small intestine and lymph node, and related mouse phenotypes are muscle and embryogenesis.

OMIM:49 In a review article on the genetic predisposition to gastric cancer, Bevan and Houlston (1999) concluded that several... (613659) more...

Related Diseases for Gastric Cancer, Somatic

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Diseases related to Gastric Cancer, Somatic via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 682)
idRelated DiseaseScoreTop Affiliating Genes
1gastrointestinal system cancer31.9APC, KRAS, MUTYH
2stomach disease31.2CDH1, ERBB2, FGFR2, KRAS, PIK3CA, TFF1
3gastrointestinal system disease31.0APC, CDH1, ERBB2, KRAS, MUTYH, PIK3CA
4esophageal cancer30.9CDH1, ERBB2, KRAS, PIK3CA
5cell type cancer30.8APC, KRAS, MUTYH
6colonic disease30.5APC, MUTYH, PIK3CA
7hepatocellular carcinoma30.5APC, CDH1, GLUL, KLF6, PIK3CA
8intestinal disease30.4APC, KRAS, MUTYH
9gastric cancer risk after h. pylori infection30.4CDH1, KRAS
10gastric cardia carcinoma30.3CDH1, ERBB2, TFF1
11lung cancer susceptibility 330.1CDH1, ERBB2, KRAS
12adenomatous polyposis coli30.0APC, CDH1, GLUL, MUTYH
13common variable immunodeficiency29.9APC, KRAS, MUTYH
14progesterone-receptor negative breast cancer29.8ERBB2, FGFR2, PIK3CA
15colorectal cancer29.7APC, CDH1, ERBB2, GLUL, KLF6, KRAS
16breast cancer29.6APC, CDH1, ERBB2, FGFR2, KRAS, PIK3CA
17female reproductive system disease29.6CDH1, ERBB2, KRAS, PIK3CA
18cellulitis29.5CDH1, ERBB2, KRAS, PIK3CA
19prostate cancer29.3CDH1, ERBB2, FGFR2, KLF6, KRAS, PIK3CA
20stomach cancer11.2
21diffuse gastric cancer11.0
22adenocarcinoma11.0
23peritonitis10.9
24gastritis10.9
25gastric adenocarcinoma10.9
26endotheliitis10.9
27atrophic gastritis10.8
28oral cavity cancer10.8
29oral cancer10.8
30gastrointestinal carcinoma10.8
31esophageal disease10.8
32cisplatin toxicity10.8
33lymph node cancer10.7
34lymph node disease10.7
35gastroesophageal junction adenocarcinoma10.7
36hypoxia10.7
37h. pylori infection10.7
38microinvasive gastric cancer10.7
39esophagitis10.6
40duodenitis10.6
41intestinal benign neoplasm10.6
42peritoneum cancer10.6
43duodenal ulcer10.6
44withdrawal disorder10.5
45cervical adenocarcinoma10.5
46irinotecan toxicity10.5
47pick disease10.5
48large intestine cancer10.5
49vascular cancer10.5
50vein disease10.5

Graphical network of the top 20 diseases related to Gastric Cancer, Somatic:



Diseases related to gastric cancer, somatic

Symptoms for Gastric Cancer, Somatic

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Clinical features from OMIM:

613659

HPO human phenotypes related to Gastric Cancer, Somatic:

id Description Frequency HPO Source Accession
1 somatic mutation HP:0001428
2 stomach cancer HP:0012126

Drugs & Therapeutics for Gastric Cancer, Somatic

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FDA approved drugs:

id Drug Name Active Ingredient(s)15 Company Approval Date
1
Herceptin15 41 TRASTUZUMAB Genentech October 1998
FDA Label: Herceptin
Disease/s that Drug Treats:Breast cancer/gastric cancer
Indications and Usage:15 Herceptin is a HER2/neu receptor antagonist indicated for: the treatment of HER2 overexpressing breast cancer (1.1, 1.2). the treatment of HER2-overexpressing metastatic gastric orgastroesophageal junction adenocarcinoma (1.3)
DrugBank Targets:13 1. Receptor tyrosine-protein kinase erbB-2;2. Epidermal growth factor receptor;3. Complement C1r subcomponent;4. Complement C1q subcomponent subunit A;5. Complement C1q subcomponent subunit B;6. Complement C1q subcomponent subunit C;7. Complement C1s subcomponent;8. High affinity immunoglobulin gamma Fc receptor I;9. Low affinity immunoglobulin gamma Fc region receptor II-a;10. Low affinity immunoglobulin gamma Fc region receptor II-b;11. Low affinity immunoglobulin gamma Fc region receptor II-c;12. Low affinity immunoglobulin gamma Fc region receptor III-B;13. Low affinity immunoglobulin gamma Fc region receptor III-A
Mechanism of Action:15 
Target: human epidermal growth factor receptor 2 protein (HER2)
Action: binds with strong affinity for immune response
FDA: The HER2 (or c-erbB2) proto-oncogene encodes a transmembrane receptor protein of 185 kDa, which is structurally related to the epidermal growth factor receptor. Herceptin has been shown, in both in vitro assays and in animals, to inhibit the proliferation of human tumor cells that overexpress HER2. Herceptin is a mediator of antibody-dependent cellular cytotoxicity (ADCC). In vitro, Herceptin-mediated ADCC has been shown to be preferentially exerted on HER2 overexpressing cancer cells compared with cancer cells that do not overexpress HER2.

Interventional clinical trials:

idNameStatusNCT IDPhase
1An Open-label, Phase 2 Study of Neratinib in Patients With Solid Tumors With Somatic Human Epidermal Growth Factor Receptor (EGFR, HER2, HER3) Mutations or EGFR Gene AmplificationRecruitingNCT01953926Phase 2
2A Study of Oral Rucaparib in Patients With a Solid Tumor (Phase I) or With gBRCA Mutation Ovarian Cancer (Phase II)RecruitingNCT01482715Phase 1, Phase 2
3A Study of Rucaparib in Patients With Pancreatic Cancer and a Known Deleterious BRCA MutationActive, not recruitingNCT02042378Phase 2

Search NIH Clinical Center for Gastric Cancer, Somatic

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Gastric Cancer, Somatic cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Gastric Cancer, Somatic:
Tumor infiltrating lymphocytes (TILs) for solid tumors
Embryonic/Adult Cultured Cells Related to Gastric Cancer, Somatic:
Tumor infiltrating lymphocytes, PMIDs: 24329789, 19342963, 23904171, 21498393, 22996367, 19304471, 22555974, 15800326, 23650429, 21325070, 24218514, 8170938, 12242449

Genetic Tests for Gastric Cancer, Somatic

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Genetic tests related to Gastric Cancer, Somatic:

id Genetic test Affiliating Genes
1 Gastric Cancer, Somatic22 FGFR2, KRAS

Anatomical Context for Gastric Cancer, Somatic

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MalaCards organs/tissues related to Gastric Cancer, Somatic:

33
Colon, Small intestine, Lymph node, Breast

Animal Models for Gastric Cancer, Somatic or affiliated genes

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MGI Mouse Phenotypes related to Gastric Cancer, Somatic:

38 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.7APC, ERBB2, FGFR2, KRAS, NEU1, PIK3CA
2MP:00053808.2APC, CDH1, ERBB2, FGFR2, KLF6, KRAS
3MP:00053818.1APC, CDH1, ERBB2, FGFR2, KRAS, TFF1
4MP:00036317.7APC, ERBB2, FGFR2, GLUL, KRAS, MUTYH
5MP:00053857.4APC, CDH1, ERBB2, FGFR2, IRF1, KLF6
6MP:00053877.2APC, BTRC, CDH1, FGFR2, IRF1, KRAS
7MP:00053787.1APC, CDH1, ERBB2, FGFR2, GLUL, KLF6
8MP:00053797.0APC, CDH1, ERBB2, FGFR2, KLF6, KRAS
9MP:00053897.0APC, BTRC, CDH1, ERBB2, FGFR2, KLF6
10MP:00053846.7APC, BTRC, CDH1, ERBB2, FGFR2, IRF1
11MP:00107716.5APC, CDH1, ERBB2, FGFR2, IRF1, KLF6
12MP:00020066.5APC, BTRC, CDH1, ERBB2, FGFR2, IRF1
13MP:00107686.1APC, BTRC, CDH1, ERBB2, FGFR2, GLUL
14MP:00053765.9APC, CDH1, ERBB2, FGFR2, GLUL, IRF1

Publications for Gastric Cancer, Somatic

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Variations for Gastric Cancer, Somatic

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UniProtKB/Swiss-Prot genetic disease variations for Gastric Cancer, Somatic:

67 (show all 20)
id Symbol AA change Variation ID SNP ID
1APCp.Gly817CysVAR_005035
2APCp.Ile880ThrVAR_005036
3APCp.Asn942AspVAR_005039
4APCp.Gly1120GluVAR_005042rs28933379
5APCp.Arg1171HisVAR_005043
6APCp.Phe1197SerVAR_005045
7APCp.Ile1259ThrVAR_005046
8APCp.Gly1312GluVAR_005050
9APCp.Val1326AlaVAR_005052
10CASP10p.Met147ThrVAR_037428rs121909776
11IRF1p.Met8LeuVAR_065134
12IRF1p.Trp11ArgVAR_065135
13KRASp.Gly12ValVAR_006840
14KRASp.Gly12AspVAR_016026
15KRASp.Gly12SerVAR_016028
16KRASp.Gly13AspVAR_016029
17KRASp.Ala59ThrVAR_016030
18KRASp.Lys5AsnVAR_064849
19MUTYHp.Pro402SerVAR_026049
20MUTYHp.Gln411ArgVAR_026050

Clinvar genetic disease variations for Gastric Cancer, Somatic:

5 (show all 17)
id Gene Variation Type Significance SNP ID Assembly Location
1CDH1NM_004360.3(CDH1): c.2494G> A (p.Val832Met)single nucleotide variantLikely pathogenic, Pathogenicrs35572355GRCh37Chr 16, 68867247: 68867247
2KRASNM_033360.3(KRAS): c.35G> A (p.Gly12Asp)single nucleotide variantPathogenic, drug responsers121913529GRCh37Chr 12, 25398284: 25398284
3KRASNM_033360.3(KRAS): c.34G> A (p.Gly12Ser)single nucleotide variantPathogenic, drug responsers121913530GRCh37Chr 12, 25398285: 25398285
4TP53NM_000546.5(TP53): c.847C> T (p.Arg283Cys)single nucleotide variantLikely pathogenicrs149633775GRCh37Chr 17, 7577091: 7577091
5FGFR2NM_000141.4(FGFR2): c.799T> C (p.Ser267Pro)single nucleotide variantPathogenicrs121918505GRCh37Chr 10, 123279633: 123279633
6PIK3CANM_006218.2(PIK3CA): c.3140A> G (p.His1047Arg)single nucleotide variantPathogenicrs121913279GRCh37Chr 3, 178952085: 178952085
7PIK3CANM_006218.2(PIK3CA): c.1633G> A (p.Glu545Lys)single nucleotide variantPathogenicrs104886003GRCh37Chr 3, 178936091: 178936091
8PIK3CANM_006218.2(PIK3CA): c.3203dupA (p.Asn1068Lysfs)duplicationPathogenicrs587776802GRCh37Chr 3, 178952148: 178952148
9ERBB2NM_001005862.2(ERBB2): c.2236G> A (p.Gly746Ser)single nucleotide variantPathogenicrs28933369GRCh37Chr 17, 37880997: 37880997
10IRF1NM_002198.2(IRF1): c.22A> T (p.Met8Leu)single nucleotide variantPathogenicrs121912469GRCh37Chr 5, 131825149: 131825149
11MUTYHNM_001128425.1(MUTYH): c.1213C> T (p.Pro405Ser)single nucleotide variantPathogenicrs121908382GRCh37Chr 1, 45797202: 45797202
12MUTYHNM_001128425.1(MUTYH): c.1241A> G (p.Gln414Arg)single nucleotide variantPathogenicrs121908383GRCh37Chr 1, 45797174: 45797174
13KLF6NM_001300.5(KLF6): c.465C> A (p.Ser155Arg)single nucleotide variantPathogenicrs121909144GRCh37Chr 10, 3824044: 3824044
14CASP10NM_032977.3(CASP10): c.769C> T (p.Gln257Ter)single nucleotide variantPathogenicrs121909775GRCh37Chr 2, 202070652: 202070652
15CASP10NM_032977.3(CASP10): c.440T> C (p.Met147Thr)single nucleotide variantPathogenicrs121909776GRCh37Chr 2, 202052521: 202052521
16APCNM_000038.5(APC): c.3359G> A (p.Gly1120Glu)single nucleotide variantPathogenicrs28933379GRCh37Chr 5, 112174650: 112174650
17APCNM_000038.5(APC): c.3199C> T (p.Gln1067Ter)single nucleotide variantPathogenicrs137854571GRCh37Chr 5, 112174490: 112174490

Cosmic variations for Gastric Cancer, Somatic:

7 (show top 50)    (show all 810)
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
143767TP53stomach,NS,carcinoma,adenocarcinoma3
244219TP53stomach,NS,carcinoma,adenocarcinoma3
310779TP53stomach,NS,carcinoma,adenocarcinoma3
443687TP53stomach,NS,carcinoma,adenocarcinoma3
510777TP53stomach,NS,carcinoma,adenocarcinoma3
643555TP53stomach,NS,carcinoma,adenocarcinoma3
710911TP53stomach,NS,carcinoma,adenocarcinoma3
810893TP53stomach,NS,carcinoma,adenocarcinoma3
944969TP53stomach,NS,carcinoma,adenocarcinoma3
1045620TP53stomach,NS,carcinoma,adenocarcinoma3
1146103TP53stomach,NS,carcinoma,adenocarcinoma3
126815TP53stomach,NS,carcinoma,adenocarcinoma3
1343642TP53stomach,NS,carcinoma,adenocarcinoma3
1444312TP53stomach,NS,carcinoma,adenocarcinoma3
1544018TP53stomach,NS,carcinoma,adenocarcinoma3
1645820TP53stomach,NS,carcinoma,adenocarcinoma3
1743657TP53stomach,NS,carcinoma,adenocarcinoma3
1843726TP53stomach,NS,carcinoma,adenocarcinoma3
1943725TP53stomach,NS,carcinoma,adenocarcinoma3
2011071TP53stomach,NS,carcinoma,adenocarcinoma3
2110709TP53stomach,NS,carcinoma,adenocarcinoma3
2244120TP53stomach,NS,carcinoma,adenocarcinoma3
2311462TP53stomach,NS,carcinoma,adenocarcinoma3
2444831TP53stomach,NS,carcinoma,adenocarcinoma3
2510992TP53stomach,NS,carcinoma,adenocarcinoma3
2610722TP53stomach,NS,carcinoma,adenocarcinoma3
2710995TP53stomach,NS,carcinoma,adenocarcinoma3
2810647TP53stomach,NS,carcinoma,adenocarcinoma3
2910957TP53stomach,NS,carcinoma,adenocarcinoma3
3011133TP53stomach,NS,carcinoma,adenocarcinoma3
3110739TP53stomach,NS,carcinoma,adenocarcinoma3
3243826TP53stomach,NS,carcinoma,adenocarcinoma3
3343606TP53stomach,NS,carcinoma,adenocarcinoma3
3444126TP53stomach,NS,carcinoma,adenocarcinoma3
3511524TP53stomach,NS,carcinoma,adenocarcinoma3
3643708TP53stomach,NS,carcinoma,adenocarcinoma3
3744512TP53stomach,NS,carcinoma,adenocarcinoma3
3843778TP53stomach,NS,carcinoma,adenocarcinoma3
3943823TP53stomach,NS,carcinoma,adenocarcinoma3
4010801TP53stomach,NS,carcinoma,adenocarcinoma3
4144249TP53stomach,NS,carcinoma,adenocarcinoma3
4243683TP53stomach,NS,carcinoma,adenocarcinoma3
4343851TP53stomach,NS,carcinoma,adenocarcinoma3
4443742TP53stomach,NS,carcinoma,adenocarcinoma3
4510670TP53stomach,NS,carcinoma,adenocarcinoma3
4644630TP53stomach,NS,carcinoma,adenocarcinoma3
4745047TP53stomach,NS,carcinoma,adenocarcinoma3
4811501TP53stomach,NS,carcinoma,adenocarcinoma3
4945233TP53stomach,NS,carcinoma,adenocarcinoma3
5010646TP53stomach,NS,carcinoma,adenocarcinoma3

Expression for genes affiliated with Gastric Cancer, Somatic

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Search GEO for disease gene expression data for Gastric Cancer, Somatic.

Pathways for genes affiliated with Gastric Cancer, Somatic

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Pathways related to Gastric Cancer, Somatic according to GeneCards Suite gene sharing:

(show all 31)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6BTRC, PIK3CA
29.5CDH1, PIK3CA
39.5CDH1, PIK3CA
49.5IRF1, KRAS, PIK3CA
5
VEGF Pathway (Tocris)
Show member pathways
9.5IRF1, KRAS, PIK3CA
6
Show member pathways
9.4FGFR2, KRAS, PIK3CA
79.4ERBB2, FGFR2, KRAS
8
Show member pathways
9.4ERBB2, KRAS, PIK3CA
9
Show member pathways
9.4ERBB2, KRAS, PIK3CA
109.2CDH1, FGFR2, PIK3CA
119.2CASP10, CDH1, ERBB2
12
Show member pathways
9.2APC, FGFR2, KRAS, PIK3CA
139.2APC, CDH1, KRAS
149.2APC, FGFR2, KRAS, PIK3CA
159.2CDH1, ERBB2, PIK3CA
169.2APC, ERBB2, KRAS, PIK3CA
17
Show member pathways
9.1ERBB2, IRF1, KRAS, PIK3CA
189.1ERBB2, FGFR2, KRAS, PIK3CA
199.1CDH1, ERBB2, KRAS
209.1APC, BTRC, CDH1
21
Show member pathways
8.8CASP10, ERBB2, FGFR2, KRAS, PIK3CA
228.8APC, BTRC, CASP10, CDH1
23
Show member pathways
8.8CDH1, ERBB2, KRAS, PIK3CA
24
Show member pathways
8.5APC, CDH1, ERBB2, KRAS, PIK3CA
25
Show member pathways
8.5APC, CDH1, ERBB2, KRAS, PIK3CA
26
Show member pathways
8.5CDH1, ERBB2, FGFR2, KRAS, PIK3CA
27
Show member pathways
8.3APC, BTRC, ERBB2, FGFR2, KRAS, PIK3CA
28
Show member pathways
8.3APC, BTRC, ERBB2, FGFR2, KRAS, PIK3CA
298.2APC, CDH1, ERBB2, FGFR2, KRAS, PIK3CA
308.1APC, CASP10, ERBB2, KRAS, PIK3CA, TFF1
31
Show member pathways
8.0APC, BTRC, CDH1, ERBB2, FGFR2, KRAS

GO Terms for genes affiliated with Gastric Cancer, Somatic

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Cellular components related to Gastric Cancer, Somatic according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1catenin complexGO:00163429.6APC, CDH1
2lamellipodiumGO:00300279.3APC, CDH1, PIK3CA

Biological processes related to Gastric Cancer, Somatic according to GeneCards Suite gene sharing:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1regulation of osteoblast differentiationGO:004566710.6APC, FGFR2
2regulation of microtubule-based processGO:003288610.3APC, ERBB2
3regulation of ERK1 and ERK2 cascadeGO:007037210.3ERBB2, FGFR2
4regulation of epithelial cell proliferationGO:005067810.1CDH1, FGFR2
5phosphatidylinositol-mediated signalingGO:004801510.0ERBB2, FGFR2, PIK3CA
6positive regulation of epithelial cell proliferationGO:00506799.9ERBB2, FGFR2, GLUL
7regulation of cell cycleGO:00517269.7APC, BTRC, IRF1
8insulin receptor signaling pathwayGO:00082869.3ERBB2, FGFR2, KRAS, PIK3CA
9fibroblast growth factor receptor signaling pathwayGO:00085439.3ERBB2, FGFR2, KRAS, PIK3CA
10negative regulation of cell proliferationGO:00082859.3APC, FGFR2, IRF1, TFF1
11neurotrophin TRK receptor signaling pathwayGO:00480119.2ERBB2, FGFR2, KRAS, PIK3CA
12epidermal growth factor receptor signaling pathwayGO:00071739.1ERBB2, FGFR2, KRAS, PIK3CA
13vascular endothelial growth factor receptor signaling pathwayGO:00480109.1ERBB2, FGFR2, KRAS, PIK3CA
14Fc-epsilon receptor signaling pathwayGO:00380958.8BTRC, ERBB2, FGFR2, KRAS, PIK3CA
15apoptotic processGO:00069158.7APC, CASP10, CDH1, FGFR2, IRF1
16innate immune responseGO:00450878.0BTRC, CASP10, ERBB2, FGFR2, KRAS, PIK3CA

Molecular functions related to Gastric Cancer, Somatic according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1gamma-catenin bindingGO:004529510.2APC, CDH1
2beta-catenin bindingGO:00080139.6APC, BTRC, CDH1
3protein bindingGO:00055154.7APC, BTRC, CASP10, CDH1, ERBB2, FGFR2

Sources for Gastric Cancer, Somatic

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet