MCID: GST060
MIFTS: 47

Gastric Cancer, Somatic malady

Categories: Genetic diseases, Gastrointestinal diseases, Cancer diseases

Aliases & Classifications for Gastric Cancer, Somatic

Aliases & Descriptions for Gastric Cancer, Somatic:

Name: Gastric Cancer, Somatic 54 24 13 38
Malignant Neoplasm of Stomach 69
Gastric Cancer Intestinal 66
Stomach Carcinoma 69
Gastric Cancer 66
Stomach Cancer 66
Gasc 66

Characteristics:

HPO:

32
gastric cancer, somatic:
Inheritance somatic mutation


Classifications:



External Ids:

OMIM 54 613659
MeSH 42 D013274

Summaries for Gastric Cancer, Somatic

UniProtKB/Swiss-Prot : 66 Gastric cancer: A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease.

MalaCards based summary : Gastric Cancer, Somatic, also known as malignant neoplasm of stomach, is related to familial stomach cancer and gastric cancer risk after h. pylori infection, and has symptoms including stomach cancer, abdominal pain and constipation. An important gene associated with Gastric Cancer, Somatic is MUTYH (MutY DNA Glycosylase), and among its related pathways/superpathways are Glioma and Apoptosis Modulation and Signaling. The drugs Rucaparib and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include colon, lymph node and small intestine, and related phenotypes are Increased shRNA abundance and cellular

OMIM : 54 In a review article on the genetic predisposition to gastric cancer, Bevan and Houlston (1999) concluded that several... (613659) more...

Related Diseases for Gastric Cancer, Somatic

Diseases related to Gastric Cancer, Somatic via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)
id Related Disease Score Top Affiliating Genes
1 familial stomach cancer 12.3
2 gastric cancer risk after h. pylori infection 11.0
3 htr2a-related altered drug metabolism 10.2 APC MUTYH
4 hereditary sensory and autonomic neuropathy with deafness and global delay 10.2 APC MUTYH
5 autoimmune autonomic ganglionopathy 10.2 APC MUTYH
6 familial hypopituitarism 10.2 APC CDH1 MUTYH
7 asperger syndrome 10.2 APC CDH1 MUTYH
8 chronic venous insufficiency 10.1 APC KRAS
9 hepatocellular carcinoma 10.1 CDH1 KRAS
10 bronchiolitis obliterans with obstructive pulmonary disease 10.1 CDH1 PIK3CA
11 glossopharyngeal motor neuropathy 10.1 CDH1 ERBB2
12 diphallia 10.1 CDH1 ERBB2
13 urethral cancer 10.1 KRAS PIK3CA
14 melanocytic nevus syndrome, congenital, somatic 10.0 KRAS PIK3CA
15 mitochondrial neurogastrointestinal encephalopathy disease 10.0 APC KRAS MUTYH
16 infantile thalamic degeneration 10.0 APC KRAS MUTYH
17 hypogonadotropic hypogonadism 14 with or without anosmia 10.0 ERBB2 FGFR2
18 adult syndrome 10.0 KRAS PIK3CA
19 gastroesophageal junction adenocarcinoma 10.0 CDH1 FGFR2 KRAS
20 basaloid squamous cell carcinoma 10.0 CDH1 ERBB2
21 hidradenoma 10.0 APC KRAS MUTYH
22 precursor t-lymphoblastic lymphoma/leukemia 10.0 KRAS PIK3CA
23 congenital symblepharon 10.0 KRAS MTHFR MUTYH
24 intestinal neuroendocrine benign tumor 9.9 ERBB2 PIK3CA
25 pancreatic cystadenoma 9.9 FGFR2 KRAS PIK3CA
26 infiltrating angiolipoma 9.9 ERBB2 PIK3CA
27 gastric cancer 9.9
28 advanced sleep phase syndrome 9.9 CDH1 KRAS MTHFR MUTYH
29 progesterone-receptor negative breast cancer 9.9 ERBB2 FGFR2 PIK3CA
30 pearson syndrome 9.8 CDH1 ERBB2 KRAS
31 hnrnpa1-related amyotrophic lateral sclerosis 9.8 APC KRAS MTHFR MUTYH
32 pulmonary fibrosis and/or bone marrow failure, telomere-related, 1 9.8 CDH1 ERBB2 KRAS
33 facial dermatosis 9.8 CDH1 ERBB2 KRAS
34 bladder colonic type adenocarcinoma 9.8 APC KRAS MUTYH
35 malignant pleural solitary fibrous tumor 9.8 CDH1 ERBB2 KRAS
36 spongiotic dermatitis 9.8 ERBB2 KRAS PIK3CA
37 vascular hemostatic disease 9.8 ERBB2 KRAS PIK3CA
38 ideomotor apraxia 9.7 APC CDH1 KRAS MTHFR MUTYH
39 nemaline myopathy 8, autosomal recessive 9.7 CDH1 ERBB2 KRAS PIK3CA
40 testicular cancer 9.7 CDH1 ERBB2 FGFR2 KRAS
41 dental caries 9.7 CDH1 ERBB2 KRAS PIK3CA
42 nasal cavity disease 9.7 CDH1 ERBB2 KRAS PIK3CA
43 trachea squamous cell carcinoma 9.7 CDH1 ERBB2 KRAS PIK3CA
44 placenta praevia 9.7 CDH1 ERBB2 KRAS PIK3CA
45 ladd syndrome 9.7 CDH1 ERBB2 KRAS PIK3CA
46 rhinosporidiosis 9.7 CDH1 ERBB2 KRAS PIK3CA
47 hypogonadotropic hypogonadism 20 with or without anosmia 9.6 CDH1 ERBB2 PIK3CA
48 nail disorder, nonsyndromic congenital, 3, 9.6 CDH1 ERBB2 KRAS PIK3CA
49 glycogen storage disease 9.6 APC CASP10 CDH1 ERBB2 KRAS
50 proctitis 9.6 CDH1 ERBB2 KRAS MUTYH PIK3CA

Comorbidity relations with Gastric Cancer, Somatic via Phenotypic Disease Network (PDN): (show all 12)


Active Peptic Ulcer Disease Acute Cystitis
Deficiency Anemia Gastric Cancer
Gastric Fundus Cancer Heart Disease
Intestinal Obstruction Iron Deficiency Anemia
Neutropenia Protein-Energy Malnutrition
Pylorus Cancer Stomach Carcinoma in Situ

Graphical network of the top 20 diseases related to Gastric Cancer, Somatic:



Diseases related to Gastric Cancer, Somatic

Symptoms & Phenotypes for Gastric Cancer, Somatic

Clinical features from OMIM:

613659

Human phenotypes related to Gastric Cancer, Somatic:

32
id Description HPO Frequency HPO Source Accession
1 stomach cancer 32 HP:0012126

UMLS symptoms related to Gastric Cancer, Somatic:


abdominal pain, constipation, diarrhea, dyspepsia, heartburn, icterus, nausea and vomiting, gastrointestinal gas

GenomeRNAi Phenotypes related to Gastric Cancer, Somatic according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.92 FGFR2 MTHFR MUTYH APC

MGI Mouse Phenotypes related to Gastric Cancer, Somatic:

44 (show all 16)
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.25 APC CDH1 CTNNBIP1 ERBB2 FGFR2 IRF1
2 cardiovascular system MP:0005385 10.21 APC CDH1 CTNNBIP1 ERBB2 FGFR2 IRF1
3 growth/size/body region MP:0005378 10.15 APC CDH1 CTNNBIP1 ERBB2 FGFR2 KLF6
4 mortality/aging MP:0010768 10.14 ERBB2 FGFR2 IRF1 KLF6 KRAS MTHFR
5 embryo MP:0005380 10.13 APC CDH1 CTNNBIP1 ERBB2 FGFR2 KLF6
6 homeostasis/metabolism MP:0005376 10.13 MTHFR MUTYH PIK3CA APC CDH1 ERBB2
7 endocrine/exocrine gland MP:0005379 10.11 APC CDH1 ERBB2 FGFR2 IRF1 KLF6
8 integument MP:0010771 10.11 APC CDH1 ERBB2 FGFR2 IRF1 KLF6
9 digestive/alimentary MP:0005381 10.01 APC CDH1 CTNNBIP1 ERBB2 FGFR2 KRAS
10 neoplasm MP:0002006 9.97 CDH1 ERBB2 FGFR2 IRF1 KRAS MUTYH
11 nervous system MP:0003631 9.92 APC CTNNBIP1 ERBB2 FGFR2 KRAS MTHFR
12 limbs/digits/tail MP:0005371 9.83 APC ERBB2 FGFR2 KRAS MTHFR
13 reproductive system MP:0005389 9.76 APC CDH1 ERBB2 FGFR2 KLF6 KRAS
14 no phenotypic analysis MP:0003012 9.73 APC CDH1 FGFR2 KRAS MTHFR PIK3CA
15 skeleton MP:0005390 9.56 MTHFR PIK3CA APC CTNNBIP1 ERBB2 FGFR2
16 vision/eye MP:0005391 9.1 APC CTNNBIP1 FGFR2 KRAS MTHFR PIK3CA

Drugs & Therapeutics for Gastric Cancer, Somatic

Drugs for Gastric Cancer, Somatic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rucaparib Approved, Investigational Phase 2,Phase 1 283173-50-2 9931954
2
Carboplatin Approved Phase 1, Phase 2 41575-94-4 10339178 498142 38904
3
Olaparib Approved Phase 1, Phase 2 763113-22-0 23725625
4 Poly(ADP-ribose) Polymerase Inhibitors Phase 2,Phase 1
5 Antibodies Phase 1, Phase 2
6 Antibodies, Monoclonal Phase 1, Phase 2
7 Immunoglobulins Phase 1, Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 A Study of Rucaparib in Patients With Pancreatic Cancer and a Known Deleterious BRCA Mutation Completed NCT02042378 Phase 2
2 Ascending Doses of AZD6738 in Combination With Chemotherapy and/or Novel Anti Cancer Agents Recruiting NCT02264678 Phase 1, Phase 2
3 A Study of Oral Rucaparib in Patients With a Solid Tumor (Phase I) or With gBRCA Mutation Ovarian Cancer (Phase II) Active, not recruiting NCT01482715 Phase 1, Phase 2
4 Phenotyping of Small Bowel Adenocarcinoma Active, not recruiting NCT02976090

Search NIH Clinical Center for Gastric Cancer, Somatic

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Gastric Cancer, Somatic cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Gastric Cancer, Somatic:
Tumor infiltrating lymphocytes (TILs) for solid tumors
Embryonic/Adult Cultured Cells Related to Gastric Cancer, Somatic:
Tumor infiltrating lymphocytes PMIDs: 24329789 19342963 23904171 21498393 22996367 19304471 22555974 15800326 23650429 21325070 24218514 8170938 12242449

Genetic Tests for Gastric Cancer, Somatic

Genetic tests related to Gastric Cancer, Somatic:

id Genetic test Affiliating Genes
1 Gastric Cancer, Somatic 24 KRAS FGFR2 PIK3CA

Anatomical Context for Gastric Cancer, Somatic

MalaCards organs/tissues related to Gastric Cancer, Somatic:

39
Colon, Lymph Node, Small Intestine

Publications for Gastric Cancer, Somatic

Variations for Gastric Cancer, Somatic

UniProtKB/Swiss-Prot genetic disease variations for Gastric Cancer, Somatic:

66 (show all 19)
id Symbol AA change Variation ID SNP ID
1 APC p.Gly817Cys VAR_005035
2 APC p.Ile880Thr VAR_005036
3 APC p.Asn942Asp VAR_005039
4 APC p.Gly1120Glu VAR_005042 rs28933379
5 APC p.Arg1171His VAR_005043 rs372481703
6 APC p.Phe1197Ser VAR_005045
7 APC p.Ile1259Thr VAR_005046
8 APC p.Gly1312Glu VAR_005050
9 APC p.Val1326Ala VAR_005052
10 CASP10 p.Met147Thr VAR_037428 rs121909776
11 IRF1 p.Met8Leu VAR_065134 rs121912469
12 IRF1 p.Trp11Arg VAR_065135 rs121912470
13 KRAS p.Gly12Val VAR_006840 rs121913529
14 KRAS p.Gly12Asp VAR_016026 rs121913529
15 KRAS p.Gly12Ser VAR_016028 rs121913530
16 KRAS p.Gly13Asp VAR_016029 rs112445441
17 KRAS p.Ala59Thr VAR_016030 rs121913528
18 KRAS p.Lys5Asn VAR_064849 rs104894361
19 MUTYH p.Pro402Ser VAR_026049 rs121908382

ClinVar genetic disease variations for Gastric Cancer, Somatic:

6 (show all 23)
id Gene Variation Type Significance SNP ID Assembly Location
1 APC NM_000038.5(APC): c.3359G> A (p.Gly1120Glu) single nucleotide variant Pathogenic rs28933379 GRCh37 Chromosome 5, 112174650: 112174650
2 APC NM_000038.5(APC): c.3199C> T (p.Gln1067Ter) single nucleotide variant Pathogenic rs137854571 GRCh37 Chromosome 5, 112174490: 112174490
3 MTHFR NM_005957.4(MTHFR): c.665C> T (p.Ala222Val) single nucleotide variant drug response rs1801133 GRCh37 Chromosome 1, 11856378: 11856378
4 MUTYH NM_001128425.1(MUTYH): c.1187G> A (p.Gly396Asp) single nucleotide variant Pathogenic rs36053993 GRCh37 Chromosome 1, 45797228: 45797228
5 MUTYH NM_001128425.1(MUTYH): c.1213C> T (p.Pro405Ser) single nucleotide variant Pathogenic rs121908382 GRCh37 Chromosome 1, 45797202: 45797202
6 MUTYH NM_001128425.1(MUTYH): c.1241A> G (p.Gln414Arg) single nucleotide variant Pathogenic rs121908383 GRCh37 Chromosome 1, 45797174: 45797174
7 KLF6 NM_001300.5(KLF6): c.465C> A (p.Ser155Arg) single nucleotide variant Pathogenic rs121909144 GRCh37 Chromosome 10, 3824044: 3824044
8 CASP10 NM_032977.3(CASP10): c.769C> T (p.Gln257Ter) single nucleotide variant Pathogenic rs121909775 GRCh37 Chromosome 2, 202070652: 202070652
9 CASP10 NM_032977.3(CASP10): c.440T> C (p.Met147Thr) single nucleotide variant Pathogenic rs121909776 GRCh37 Chromosome 2, 202052521: 202052521
10 KRAS NM_004985.4(KRAS): c.35G> A (p.Gly12Asp) single nucleotide variant Pathogenic/Likely pathogenic rs121913529 GRCh37 Chromosome 12, 25398284: 25398284
11 KRAS NM_033360.3(KRAS): c.34G> A (p.Gly12Ser) single nucleotide variant Pathogenic rs121913530 GRCh37 Chromosome 12, 25398285: 25398285
12 FGFR2 NM_000141.4(FGFR2): c.799T> C (p.Ser267Pro) single nucleotide variant Pathogenic rs121918505 GRCh37 Chromosome 10, 123279633: 123279633
13 PIK3CA NM_006218.3(PIK3CA): c.3140A> G (p.His1047Arg) single nucleotide variant Pathogenic/Likely pathogenic rs121913279 GRCh37 Chromosome 3, 178952085: 178952085
14 PIK3CA NM_006218.3(PIK3CA): c.3203dupA (p.Asn1068Lysfs) duplication Pathogenic rs587776802 GRCh37 Chromosome 3, 178952148: 178952148
15 PIK3CA NM_006218.3(PIK3CA): c.1633G> A (p.Glu545Lys) single nucleotide variant Pathogenic/Likely pathogenic rs104886003 GRCh37 Chromosome 3, 178936091: 178936091
16 ERBB2 NM_001005862.2(ERBB2): c.2236G> A (p.Gly746Ser) single nucleotide variant Pathogenic/Likely pathogenic rs28933369 GRCh37 Chromosome 17, 37880997: 37880997
17 IRF1 NM_002198.2(IRF1): c.22A> T (p.Met8Leu) single nucleotide variant Pathogenic rs121912469 GRCh37 Chromosome 5, 131825149: 131825149
18 CTNNB1 NM_001904.3(CTNNB1): c.110C> A (p.Ser37Tyr) single nucleotide variant Pathogenic/Likely pathogenic rs121913403 GRCh37 Chromosome 3, 41266113: 41266113
19 ERBB3 NM_001982.3(ERBB3): c.850G> A (p.Gly284Arg) single nucleotide variant Likely pathogenic rs1057519803 GRCh37 Chromosome 12, 56481922: 56481922
20 NRAS NM_002524.4(NRAS): c.37G> A (p.Gly13Ser) single nucleotide variant Likely pathogenic rs121434595 GRCh37 Chromosome 1, 115258745: 115258745
21 CTNNB1 NM_001904.3(CTNNB1): c.109T> C (p.Ser37Pro) single nucleotide variant Likely pathogenic rs121913228 GRCh37 Chromosome 3, 41266112: 41266112
22 CTNNB1 NM_001904.3(CTNNB1): c.118A> G (p.Thr40Ala) single nucleotide variant Likely pathogenic rs1057519836 GRCh37 Chromosome 3, 41266121: 41266121
23 MUTYH NM_001128425.1(MUTYH): c.1228_1229dupGA (p.Pro411Serfs) duplication Likely pathogenic GRCh37 Chromosome 1, 45797186: 45797187

Cosmic variations for Gastric Cancer, Somatic:

9 (show top 50) (show all 1391)
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM5576102 ZNF521 stomach,NS,carcinoma,adenocarcinoma c.443G>A p.C148Y 7
2 COSM5576231 ZNF521 stomach,NS,carcinoma,adenocarcinoma c.3434T>G p.V1145G 7
3 COSM5575704 ZNF521 stomach,NS,carcinoma,adenocarcinoma c.2285G>A p.R762H 7
4 COSM5575790 ZNF521 stomach,NS,carcinoma,adenocarcinoma c.1159G>A p.A387T 7
5 COSM5576098 ZNF384 stomach,NS,carcinoma,adenocarcinoma c.1136G>A p.R379Q 7
6 COSM5576197 XPO1 stomach,NS,carcinoma,adenocarcinoma c.479G>A p.S160N 7
7 COSM926359 WT1 stomach,NS,carcinoma,adenocarcinoma c.1298G>A p.R433H 7
8 COSM20570 WEE2 stomach,NS,carcinoma,adenocarcinoma c.996C>G p.N332K 7
9 COSM5575712 UBR5 stomach,NS,carcinoma,adenocarcinoma c.5261G>A p.R1754Q 7
10 COSM1094394 UBR5 stomach,NS,carcinoma,adenocarcinoma c.5561G>A p.R1854H 7
11 COSM5575753 TSC2 stomach,NS,carcinoma,adenocarcinoma c.2357G>A p.R786H 7
12 COSM5576247 TSC2 stomach,NS,carcinoma,adenocarcinoma c.2803G>T p.A935S 7
13 COSM5576069 TSC1 stomach,NS,carcinoma,adenocarcinoma c.2143C>T p.R715W 7
14 COSM20551 TRRAP stomach,NS,carcinoma,adenocarcinoma c.5117G>A p.R1706H 7
15 COSM20550 TRRAP stomach,NS,carcinoma,adenocarcinoma c.477A>G p.K159K 7
16 COSM2866680 TRRAP stomach,NS,carcinoma,adenocarcinoma c.5956C>T p.R1986W 7
17 COSM5575878 TRRAP stomach,NS,carcinoma,adenocarcinoma c.10447G>A p.A3483T 7
18 COSM5576201 TRRAP stomach,NS,carcinoma,adenocarcinoma c.2075A>G p.Y692C 7
19 COSM5575742 TRRAP stomach,NS,carcinoma,adenocarcinoma c.622G>A p.E208K 7
20 COSM5576203 TRRAP stomach,NS,carcinoma,adenocarcinoma c.8165C>T p.P2722L 7
21 COSM20561 TRPM7 stomach,NS,carcinoma,adenocarcinoma c.2488A>G p.M830V 7
22 COSM5575609 TRIM33 stomach,NS,carcinoma,adenocarcinoma c.1231C>T p.H411Y 7
23 COSM5575966 TRIM33 stomach,NS,carcinoma,adenocarcinoma c.817C>A p.P273T 7
24 COSM5576261 TRIM24 stomach,NS,carcinoma,adenocarcinoma c.3013C>T p.R1005C 7
25 COSM5576173 TRIM24 stomach,NS,carcinoma,adenocarcinoma c.706G>C p.E236Q 7
26 COSM5576172 TRIM24 stomach,NS,carcinoma,adenocarcinoma c.706G>C p.E236Q 7
27 COSM5576260 TRIM24 stomach,NS,carcinoma,adenocarcinoma c.3115C>T p.R1039C 7
28 COSM5575610 TPR stomach,NS,carcinoma,adenocarcinoma c.3721A>G p.S1241G 7
29 COSM44091 TP53 stomach,NS,carcinoma,adenocarcinoma c.746G>A p.R249K 7
30 COSM44151 TP53 stomach,NS,carcinoma,adenocarcinoma c.535C>A p.H179N 7
31 COSM10648 TP53 stomach,NS,carcinoma,adenocarcinoma c.524G>A p.R175H 7
32 COSM10704 TP53 stomach,NS,carcinoma,adenocarcinoma c.844C>T p.R282W 7
33 COSM10656 TP53 stomach,NS,carcinoma,adenocarcinoma c.742C>T p.R248W 7
34 COSM10705 TP53 stomach,NS,carcinoma,adenocarcinoma c.586C>T p.R196* 7
35 COSM10663 TP53 stomach,NS,carcinoma,adenocarcinoma c.916C>T p.R306* 7
36 COSM43826 TP53 stomach,NS,carcinoma,adenocarcinoma c.706T>A p.Y236N 7
37 COSM11089 TP53 stomach,NS,carcinoma,adenocarcinoma c.584T>C p.I195T 7
38 COSM10709 TP53 stomach,NS,carcinoma,adenocarcinoma c.722C>G p.S241C 7
39 COSM45620 TP53 stomach,NS,carcinoma,adenocarcinoma c.704A>C p.N235T 7
40 COSM10735 TP53 stomach,NS,carcinoma,adenocarcinoma c.638G>A p.R213Q 7
41 COSM10941 TP53 stomach,NS,carcinoma,adenocarcinoma c.730G>A p.G244S 7
42 COSM10690 TP53 stomach,NS,carcinoma,adenocarcinoma c.473G>A p.R158H 7
43 COSM11307 TP53 stomach,NS,carcinoma,adenocarcinoma c.643A>T p.S215C 7
44 COSM10883 TP53 stomach,NS,carcinoma,adenocarcinoma c.731G>A p.G244D 7
45 COSM44969 TP53 stomach,NS,carcinoma,adenocarcinoma c.424C>G p.P142A 7
46 COSM10645 TP53 stomach,NS,carcinoma,adenocarcinoma c.527G>T p.C176F 7
47 COSM44262 TP53 stomach,NS,carcinoma,adenocarcinoma c.808T>C p.F270L 7
48 COSM43559 TP53 stomach,NS,carcinoma,adenocarcinoma c.517G>T p.V173L 7
49 COSM44125 TP53 stomach,NS,carcinoma,adenocarcinoma c.486C>G p.I162M 7
50 COSM10992 TP53 stomach,NS,carcinoma,adenocarcinoma c.844C>G p.R282G 7

Expression for Gastric Cancer, Somatic

Search GEO for disease gene expression data for Gastric Cancer, Somatic.

Pathways for Gastric Cancer, Somatic

Pathways related to Gastric Cancer, Somatic according to GeneCards Suite gene sharing:

(show all 38)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.83 APC CDH1 ERBB2 FGFR2 KRAS PIK3CA
2
Show member pathways
12.68 CASP10 IRF1 KRAS PIK3CA
3
Show member pathways
12.61 APC CDH1 ERBB2 KRAS PIK3CA
4
Show member pathways
12.57 CDH1 FGFR2 KRAS PIK3CA
5
Show member pathways
12.57 ERBB2 FGFR2 KRAS PIK3CA
6 12.45 APC FGFR2 KRAS PIK3CA
7 12.35 APC ERBB2 KRAS PIK3CA
8
Show member pathways
12.33 CASP10 CDH1 ERBB2 KRAS PIK3CA
9
Show member pathways
12.32 ERBB2 IRF1 KRAS PIK3CA
10
Show member pathways
12.19 APC ERBB2 FGFR2 KRAS PIK3CA
11
Show member pathways
12.12 APC CDH1 PIK3CA
12
Show member pathways
12.08 CASP10 ERBB2 FGFR2 KRAS PIK3CA
13 12.05 APC CDH1 KRAS
14
Show member pathways
12.05 ERBB2 FGFR2 KRAS
15
Show member pathways
12.02 FGFR2 KRAS PIK3CA
16
Show member pathways
11.99 ERBB2 KRAS PIK3CA
17 11.95 APC CASP10 CDH1
18
Show member pathways
11.94 ERBB2 KRAS PIK3CA
19 11.92 APC FGFR2 KRAS PIK3CA
20
Show member pathways
11.91 APC CDH1 ERBB2 KRAS PIK3CA
21 11.9 IRF1 KRAS PIK3CA
22 11.86 APC CDH1 KRAS
23
Show member pathways
11.79 ERBB2 KRAS PIK3CA
24 11.73 APC ERBB2 KRAS PIK3CA
25 11.7 APC CDH1 ERBB2 FGFR2 KRAS PIK3CA
26
Show member pathways
11.65 CASP10 KRAS PIK3CA
27 11.62 APC CDH1 CTNNBIP1
28 11.58 CDH1 ERBB2 KRAS
29 11.36 CDH1 FGFR2 PIK3CA
30 11.15 KRAS PIK3CA
31 11.13 CDH1 KRAS
32 11.12 CDH1 ERBB2 PIK3CA
33 11.1 KRAS PIK3CA
34 11.07 ERBB2 FGFR2 KRAS PIK3CA
35 11.06 CDH1 PIK3CA
36 11.06 APC ERBB2 KRAS
37 11.03 FGFR2 PIK3CA
38 10.89 CDH1 PIK3CA

GO Terms for Gastric Cancer, Somatic

Cellular components related to Gastric Cancer, Somatic according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.91 APC CASP10 CTNNBIP1 ERBB2 IRF1 KLF6
2 lamellipodium GO:0030027 9.33 APC CDH1 PIK3CA
3 beta-catenin destruction complex GO:0030877 8.96 APC CTNNBIP1
4 catenin complex GO:0016342 8.62 APC CDH1

Biological processes related to Gastric Cancer, Somatic according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol-mediated signaling GO:0048015 9.5 ERBB2 FGFR2 PIK3CA
2 phosphatidylinositol phosphorylation GO:0046854 9.43 ERBB2 FGFR2 PIK3CA
3 regulation of multicellular organism growth GO:0040014 9.4 FGFR2 PIK3CA
4 regulation of ERK1 and ERK2 cascade GO:0070372 9.37 ERBB2 FGFR2
5 regulation of microtubule-based process GO:0032886 9.16 APC ERBB2
6 regulation of phosphatidylinositol 3-kinase signaling GO:0014066 9.13 ERBB2 FGFR2 PIK3CA
7 ERBB2 signaling pathway GO:0038128 8.8 ERBB2 KRAS PIK3CA

Molecular functions related to Gastric Cancer, Somatic according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 gamma-catenin binding GO:0045295 9.16 APC CDH1
2 beta-catenin binding GO:0008013 9.13 APC CDH1 CTNNBIP1
3 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 8.8 ERBB2 FGFR2 PIK3CA

Sources for Gastric Cancer, Somatic

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....