MCID: GST060
MIFTS: 47

Gastric Cancer, Somatic malady

Gastrointestinal, Cancer categories

Summaries for Gastric Cancer, Somatic

Sources:
47OMIM, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Gastric Cancer, Somatic, also known as malignant neoplasm of stomach, is related to stomach cancer and colorectal cancer. An important gene associated with Gastric Cancer, Somatic is CASP10 (caspase 10, apoptosis-related cysteine peptidase), and among its related pathways are TRAIL signaling pathway and IL6-mediated signaling events. The compounds epinephrine and af/ap have been mentioned in the context of this disorder. Affiliated tissues include colon, breast and prostate, and related mouse phenotypes are muscle and endocrine/exocrine gland.

Description from OMIM:47 613659,137215

Aliases & Classifications for Gastric Cancer, Somatic

Sources:
49Orphanet, 47OMIM, 61UMLS, 26ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Gastrointestinal


Characteristics (Orphanet epidemiological data):

49
gastric cancer:
Inheritance: Multigenic/multifactorial,Sporadic; Prevalence: 1-5/10000; Age of onset: Adulthood


Aliases & Descriptions:

gastric cancer, somatic 47
malignant neoplasm of stomach 61
gastric cancer 49
stomach cancer 49


External Ids:

OMIM47 613659
ICD10 via Orphanet26 C16

Related Diseases for Gastric Cancer, Somatic

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Gastric Cancer, Somatic via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 255)
idRelated DiseaseScoreTop Affiliating Genes
1stomach cancer31.9CASP10, IRF1, APC, PIK3CA, MUTYH, FGFR2
2colorectal cancer30.5KLF6, APC, PIK3CA, MUTYH, KRAS, ERBB2
3thyroid cancer30.3APC, PIK3CA, FGFR2
4adenocarcinoma30.2KLF6, IRF1, APC, PIK3CA, FGFR2, KRAS
5squamous cell carcinoma30.2IRF1, APC, PIK3CA, FGFR2, KRAS, ERBB2
6adenoma30.1APC, MUTYH, KRAS
7familial adenomatous polyposis30.1IRF1, APC, MUTYH, KRAS
8brain cancer29.9PIK3CA, APC, KLF6
9diffuse gastric cancer11.0
10hypoxia10.7
11stomach disease10.5
12h. pylori infection10.5
13gastric lymphoma10.5
14atrophic gastritis10.4
15peritoneal carcinoma10.4
16cronkhite-canada syndrome10.3
17microinvasive gastric cancer10.3
18situs inversus10.3
19gastric linitis plastica10.3
20ataxia telangiectasia10.3
21signet ring cell adenocarcinoma10.3
22gastric signet ring cell adenocarcinoma10.3
23spleen cancer10.3
24ataxia10.3
25cancer progression/metastasis10.3
26stomach cancer, childhood10.3
27xeroderma pigmentosum10.2
28n syndrome10.2
29plummer vinson syndrome10.2
30xeroderma pigmentosum, group c10.2
31xeroderma pigmentosum, group g10.2
32gastric ulcer10.2
33pernicious anemia10.2
34stomach cancer, familial10.2
35bone marrow cancer10.2
36gastric outlet obstruction10.2
37bone carcinoma10.2
38obstructive jaundice10.2
39gastric tubular adenocarcinoma10.2
40gastric squamous cell carcinoma10.2
41dumping syndrome10.2
42tubular adenocarcinoma10.2
43peutz-jeghers syndrome10.2
44peutz–jeghers syndrome10.2
45retroperitoneal fibrosis10.2
46esophageal squamous cell carcinoma10.2
47breast cancer, lobular10.2
48bloom syndrome10.1
49duodenal ulcer10.1
50asbestosis10.1

Graphical network of the top 20 diseases related to Gastric Cancer, Somatic:



Diseases related to gastric cancer, somatic

Clinical Features for Gastric Cancer, Somatic

Sources:
47OMIM
See all sources

Clinical features from OMIM:

613659,137215

Drugs & Therapeutics for Gastric Cancer, Somatic

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Gastric Cancer, Somatic

Drug clinical trials:

Search ClinicalTrials for Gastric Cancer, Somatic

Search NIH Clinical Center for Gastric Cancer, Somatic

Search CenterWatch for Gastric Cancer, Somatic

Genetic Tests for Gastric Cancer, Somatic

Anatomical Context for Gastric Cancer, Somatic

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Gastric Cancer, Somatic:

33
Colon, Breast, Prostate

Animal Models for Gastric Cancer, Somatic or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Gastric Cancer, Somatic

Sources:
51PubMed
See all sources

Articles related to Gastric Cancer, Somatic:

(show all 15)
idTitleAuthorsYear
1
Somatic mutations and deletions of the E-cadherin gene predict poor survival of patients with gastric cancer. (23341533)
2013
2
A frequent somatic mutation in CD274 3'-UTR leads to protein over-expression in gastric cancer by disrupting miR-570 binding. (22190470)
2012
3
Somatic mutation of a tumor suppressor gene BAP1 is rare in breast, prostate, gastric and colorectal cancers. (22958294)
2012
4
Rapid identification of mtDNA somatic mutations in gastric cancer tissues based on the mtDNA phylogeny. (21419139)
2011
5
Somatic mutations of caspase-2 gene in gastric and colorectal cancers. (21940110)
2011
6
Somatic frameshift mutations of bone morphogenic protein receptor 2 gene in gastric and colorectal cancers with microsatellite instability. (20955454)
2010
7
Somatic mutation of EXO1 gene in gastric and colorectal cancers with microsatellite instability. (20429728)
2010
8
Somatic mutations in mitochondrial genome and their potential roles in the progression of human gastric cancer. (19527772)
2010
9
Somatic mutations and losses of expression of microRNA regulation-related genes AGO2 and TNRC6A in gastric and colorectal cancers. (20198652)
2010
10
Somatic mutations of the beta-TrCP gene in gastric cancer. (17295679)
2007
11
A variant form of hMTH1, a human homologue of the E coli mutT gene, correlates with somatic mutation in the p53 tumour suppressor gene in gastric cancer patients. (15121785)
2004
12
Somatic mutations in the death domain of the Fas (Apo-1/CD95) gene in gastric cancer. (11180161)
2001
13
Somatic mutations of the trefoil factor family 1 gene in gastric cancer. (10982763)
2000
14
Frequent somatic mutations of the beta-catenin gene in intestinal-type gastric cancer. (10485468)
1999
15
Somatic mutation of the APC gene in gastric cancer: frequent mutations in very well differentiated adenocarcinoma and signet-ring cell carcinoma. (1338691)
1992

Genetic Variations for Gastric Cancer, Somatic

Sources:
63UniProtKB/Swiss-Prot
See all sources

Genetic disease variations for Gastric Cancer, Somatic:

63 (show all 20)
id Symbol AA change Variation SNP ID
1APCp.Gly817CysVAR_005035
2APCp.Ile880ThrVAR_005036
3APCp.Asn942AspVAR_005039
4APCp.Gly1120GluVAR_005042rs28933379
5APCp.Arg1171HisVAR_005043
6APCp.Phe1197SerVAR_005045
7APCp.Ile1259ThrVAR_005046
8APCp.Gly1312GluVAR_005050
9APCp.Val1326AlaVAR_005052
10CASP10p.Met147ThrVAR_037428rs121909776
11IRF1p.Met8LeuVAR_065134
12IRF1p.Trp11ArgVAR_065135
13KRASp.Gly12ValVAR_006840
14KRASp.Gly12AspVAR_016026
15KRASp.Gly12SerVAR_016028
16KRASp.Gly13AspVAR_016029
17KRASp.Ala59ThrVAR_016030
18KRASp.Lys5AsnVAR_064849
19MUTYHp.Pro402SerVAR_026049
20MUTYHp.Gln411ArgVAR_026050

Expression for genes affiliated with Gastric Cancer, Somatic

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Gastric Cancer, Somatic

Search GEO for disease gene expression data for Gastric Cancer, Somatic.

Pathways for genes affiliated with Gastric Cancer, Somatic

Sources:
38NCBI BioSystems Database, 30KEGG, 54Reactome, 12EMD Millipore, 52QIAGEN, 50PharmGKB, 60Tocris Bioscience, 53R&D Systems
See all sources

Pathways related to Gastric Cancer, Somatic according to GeneCards/GeneDecks:

(show all 41)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.6CASP10, PIK3CA
29.6PIK3CA, IRF1
39.5FGFR2, PIK3CA
49.5PIK3CA, FGFR2
5
Hide members
9.5KRAS, FGFR2
69.4PIK3CA, KRAS
79.4KRAS, PIK3CA
8
Hide members
9.4KRAS, PIK3CA
99.4PIK3CA, KRAS
109.3APC, PIK3CA
119.2ERBB2, FGFR2
12
Hide members
9.2FGFR2, PIK3CA, CASP10
139.1ERBB2, PIK3CA
149.1PIK3CA, ERBB2
15
Hide members
9.1ERBB2, KRAS
16
Hide members
9.1KRAS, PIK3CA, CASP10
179.1IRF1, PIK3CA, KRAS
18
Hide members
9.1KRAS, PIK3CA, IRF1
19
Hide members
9.1KRAS, PIK3CA, IRF1
20
Hide members
9.0KRAS, FGFR2, PIK3CA
21
Hide members
9.0PIK3CA, FGFR2, KRAS
228.8KRAS, PIK3CA, APC
238.7ERBB2, KRAS, FGFR2
248.6ERBB2, KRAS, PIK3CA
25
Hide members
8.6PIK3CA, KRAS, ERBB2
26
Translation Insulin regulation of translation
Hide members
8.6PIK3CA, KRAS, ERBB2
27
Hide members
8.6ERBB2, KRAS, PIK3CA
28
Hide members
8.4KRAS, FGFR2, PIK3CA, APC
29
Development Prolactin receptor signaling
Hide members
8.3ERBB2, KRAS, PIK3CA, IRF1
30
Hide members
8.2PIK3CA, FGFR2, KRAS, ERBB2
31
Hide members
8.2PIK3CA, FGFR2, KRAS, ERBB2
32
Hide members
8.2ERBB2, KRAS, FGFR2, PIK3CA
338.2ERBB2, KRAS, FGFR2, PIK3CA
34
Hide members
8.2PIK3CA, FGFR2, KRAS, ERBB2
358.0APC, PIK3CA, KRAS, ERBB2
36
Hide members
8.0APC, PIK3CA, KRAS, ERBB2
37
Hide members
8.0APC, PIK3CA, KRAS, ERBB2
38
Hide members
7.8ERBB2, KRAS, FGFR2, PIK3CA, CASP10
397.7CASP10, APC, PIK3CA, KRAS, ERBB2
40
Hide members
7.5ERBB2, KRAS, FGFR2, PIK3CA, APC
417.5ERBB2, KRAS, FGFR2, PIK3CA, APC

Compounds for genes affiliated with Gastric Cancer, Somatic

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Gastric Cancer, Somatic according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1epinephrine45 11 2412.1FGFR2
2af/ap459.9MUTYH, APC
38-oxoguanine459.7MUTYH, APC
4o6-methylguanine459.5KRAS, APC
5adenine45 11 2411.5MUTYH, APC, IRF1
6everolimus50 45 1111.4PIK3CA, ERBB2
75-methylthioadenosine459.4ERBB2, FGFR2
8adp45 29 2411.4KLF6, APC, FGFR2
9crcs459.2KRAS, PIK3CA, APC
10trastuzumab45 50 1111.1ERBB2, FGFR2, PIK3CA
11erlotinib45 50 1111.0ERBB2, KRAS, PIK3CA
12gefitinib45 50 1111.0PIK3CA, KRAS, ERBB2
13imatinib45 50 1110.9ERBB2, KRAS, PIK3CA
14agar458.9ERBB2, FGFR2, PIK3CA
15etoposide45 50 60 1111.9ERBB2, PIK3CA, IRF1
16cetuximab45 50 1110.8KRAS, ERBB2
17oligonucleotide458.8IRF1, APC, FGFR2, KRAS
18nitric oxide45 11 2410.7FGFR2, PIK3CA, IRF1, KLF6
19tamoxifen45 50 29 1111.7IRF1, PIK3CA, FGFR2, ERBB2
20guanine45 11 2410.6APC, MUTYH, FGFR2, ERBB2
21paclitaxel45 50 1110.6PIK3CA, FGFR2, KRAS, ERBB2
22phosphotyrosine458.6ERBB2, FGFR2, PIK3CA
235fluorouracil458.5PIK3CA, FGFR2, KRAS, ERBB2
24adenylate458.5KLF6, IRF1, APC, PIK3CA, FGFR2
25vitamin d458.4APC, FGFR2, KRAS, ERBB2
26paraffin458.4ERBB2, KRAS, FGFR2, APC
27heparin45 29 11 2411.4APC, PIK3CA, FGFR2, ERBB2
28wortmannin458.3APC, PIK3CA, KRAS, ERBB2
29retinoic acid45 249.3IRF1, APC, PIK3CA, FGFR2, KRAS
30progesterone45 60 29 11 2412.3ERBB2, FGFR2, PIK3CA, APC
31arginine458.3IRF1, PIK3CA, FGFR2, ERBB2
32testosterone45 60 11 2411.3APC, PIK3CA, FGFR2, ERBB2
33vegf458.3PIK3CA, FGFR2, KRAS, ERBB2
34lipid458.3IRF1, APC, PIK3CA, FGFR2, KRAS
35cisplatin45 50 60 1111.2CASP10, PIK3CA, FGFR2, KRAS, ERBB2
36h2o2458.2ERBB2, KRAS, FGFR2, MUTYH, PIK3CA
37rapamycin458.0APC, PIK3CA, FGFR2, KRAS, ERBB2
38phosphatidylinositol457.6IRF1, APC, PIK3CA, FGFR2, KRAS, ERBB2
39tyrosine457.5IRF1, APC, PIK3CA, FGFR2, KRAS, ERBB2
40serine456.9ERBB2, KLF6, CASP10, IRF1, APC, PIK3CA

GO Terms for genes affiliated with Gastric Cancer, Somatic

Sources:
16Gene Ontology
See all sources

Biological processes related to Gastric Cancer, Somatic according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1regulation of osteoblast differentiationGO:0456679.6FGFR2, APC
2regulation of multicellular organism growthGO:0400149.6FGFR2, PIK3CA
3regulation of ERK1 and ERK2 cascadeGO:0703729.4FGFR2, ERBB2
4regulation of microtubule-based processGO:0328869.2ERBB2, APC
5cytokine-mediated signaling pathwayGO:0192219.2KLF6, IRF1, KRAS
6positive regulation of MAP kinase activityGO:0434069.1ERBB2, KRAS
7insulin receptor signaling pathwayGO:0082869.1KRAS, FGFR2, PIK3CA
8neuromuscular junction developmentGO:0075289.1ERBB2, FGFR2
9phosphatidylinositol-mediated signalingGO:0480158.9PIK3CA, FGFR2, ERBB2
10apoptotic processGO:0069158.8CASP10, IRF1, APC, FGFR2
11positive regulation of cell adhesionGO:0457858.7ERBB2, APC
12fibroblast growth factor receptor signaling pathwayGO:0085438.5ERBB2, KRAS, FGFR2, PIK3CA
13Fc-epsilon receptor signaling pathwayGO:0380958.4PIK3CA, FGFR2, KRAS, ERBB2
14epidermal growth factor receptor signaling pathwayGO:0071738.4ERBB2, KRAS, FGFR2, PIK3CA
15neurotrophin TRK receptor signaling pathwayGO:0480118.4ERBB2, KRAS, FGFR2, PIK3CA
16innate immune responseGO:0450878.1CASP10, PIK3CA, FGFR2, KRAS, ERBB2

Molecular functions related to Gastric Cancer, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055156.5ERBB2, KRAS, FGFR2, MUTYH, PIK3CA, APC

Products for genes affiliated with Gastric Cancer, Somatic

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gastric Cancer, Somatic

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet