Gastric Cancer, Somatic malady

MalaCards: Gastric Cancer, Somatic, also known as malignant neoplasm of stomach, is related to diffuse gastric cancer and stomach carcinoma. An important gene associated with Gastric Cancer, Somatic is KLF6 (Kruppel-like factor 6), and among its related pathways are Development EGFR signaling via PIP3 and Development FGF-family signaling. The compounds paraffin and af/ap have been mentioned in the context of this disorder. Related mouse phenotypes are endocrine/exocrine gland and mortality/aging.

OMIM: 137215

gastric cancer, somatic 33 malignant neoplasm of stomach 43

Diseases related to gastric cancer, somatic by text searches and GeneDecks gene sharing:

(show top 50)    (show all 146)

id	Related Disease	Score	Top Affiliating Genes
1	diffuse gastric cancer	29.4	ERBB2, CDH1
2	stomach carcinoma	26.5	KLF6, FGFR2, ERBB2, CASP10, APC, IRF1
3	gastric cancer	25.0	IRF1, PIK3CA, KLF6, MUTYH, CDH1, APC
4	colorectal adenomatous polyposis	13.1	MUTYH, APC
5	mutyh-associated polyposis	13.1	MUTYH, APC
6	attenuated familial adenomatous polyposis	13.1	APC, MUTYH
7	nonsmall cell lung cancer, somatic	13.0	IRF1, PIK3CA
8	lung cancer, somatic	13.0	IRF1, PIK3CA
9	cancer progression/metastasis	12.9	KLF6, FGFR2
10	pseudomyxoma peritonei	12.9	APC, CDH1
11	colorectal cancer, somatic	12.9	APC, PIK3CA
12	germinoma	12.8	CDH1, APC
13	pseudohypoparathyroidism	12.8	APC, FGFR2
14	hereditary diffuse gastric cancer	12.6	ERBB2, CDH1
15	bile duct cancer	12.6	APC, ERBB2
16	inflammatory breast carcinoma	12.6	CDH1, ERBB2
17	breast carcinoma in situ	12.6	CDH1, ERBB2
18	penis non-invasive verrucous carcinoma	12.5	ERBB2, CDH1
19	ovarian cancer, somatic	12.5	PIK3CA, ERBB2
20	adenomatous polyposis coli	12.5	CDH1, APC, MUTYH
21	tubular adenocarcinoma	12.5	ERBB2, CDH1
22	cribriform carcinoma	12.5	CDH1, ERBB2
23	nasopharynx carcinoma	12.5	PIK3CA, KLF6, CDH1
24	uterine carcinosarcoma	12.4	CDH1, ERBB2
25	brain cancer	12.4	KLF6, PIK3CA, APC
26	papillary adenocarcinoma	12.4	ERBB2, CDH1
27	nevus	12.3	CDH1, PIK3CA, APC
28	bilateral breast cancer	12.3	PIK3CA, ERBB2
29	acute promyelocytic leukemia	12.3	CASP10, IRF1, PIK3CA
30	prostate carcinoma	12.3	KLF6, CDH1, ERBB2
31	rectum sarcomatoid carcinoma	12.3	ERBB2, CDH1
32	cervical endometrioid adenocarcinoma	12.2	ERBB2, CDH1
33	cervical intraepithelial neoplasia	12.2	PIK3CA, FGFR2, CDH1
34	small cell carcinoma	12.2	ERBB2, CDH1, KLF6
35	renal carcinoma	12.2	CDH1, IRF1, FGFR2, KLF6
36	colorectal adenoma and carcinoma	12.2	ERBB2, CDH1, APC
37	adenoid cystic carcinoma	12.1	ERBB2, CDH1
38	oligodendroglioma	12.1	PIK3CA, KLF6, ERBB2
39	rectal cloacogenic carcinoma	12.1	CDH1, ERBB2, FGFR2
40	pleomorphic adenoma	12.1	FGFR2, CDH1, ERBB2
41	synovial sarcoma	12.1	ERBB2, APC, CDH1
42	ampulla of vater carcinoma	12.1	PIK3CA, FGFR2, ERBB2
43	ovarian clear cell adenocarcinoma	12.0	CDH1, PIK3CA, ERBB2
44	skin cancer	12.0	FGFR2, PIK3CA, CDH1
45	thyroid cancer, anaplastic	12.0	CDH1, PIK3CA
46	familial colorectal cancer	12.0	APC, PIK3CA, MUTYH, CDH1
47	clear cell adenocarcinoma	12.0	ERBB2, CDH1, PIK3CA
48	estrogen-receptor positive breast cancer	12.0	PIK3CA, FGFR2, ERBB2
49	choriocarcinoma	12.0	KLF6, IRF1, FGFR2, CASP10, APC
50	stickler syndrome	12.0	CDH1, FGFR2, ERBB2

Clinical features from OMIM: 137215

Approved drugs:

Drug clinical trials:

MGI Mouse Phenotypes related to gastric cancer, somatic:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.0	FGFR2
2	mortality/aging	MP:0010768	7.8	PIK3CA, KLF6, APC, FGFR2, IRF1, CDH1
3	integument phenotype	MP:0010771	7.5	ERBB2, APC, FGFR2, IRF1, KLF6, CDH1
4	reproductive system phenotype	MP:0005389	7.2	ERBB2, FGFR2, CDH1, KLF6, PIK3CA, APC
5	embryogenesis phenotype	MP:0005380	7.1	ERBB2, APC, FGFR2, CDH1, KLF6, PIK3CA
6	cardiovascular system phenotype	MP:0005385	7.0	APC, IRF1, ERBB2, FGFR2, PIK3CA, KLF6
7	tumorigenesis	MP:0002006	6.9	APC, FGFR2, IRF1, CDH1, PIK3CA, MUTYH
8	cellular phenotype	MP:0005384	6.5	PIK3CA, IRF1, APC, ERBB2, FGFR2, CDH1

Genes related to gastric cancer, somatic according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	KLF6	Kruppel-like factor 6	11.0
2	CASP10	caspase 10, apoptosis-related cysteine peptidase	11.0
3	IRF1	interferon regulatory factor 1	11.0
4	MUTYH	mutY homolog (E. coli)	11.0
5	APC	adenomatous polyposis coli	11.0
6	FGFR2	fibroblast growth factor receptor 2	11.0
7	PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	11.0
8	ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	11.0
9	CDH1	cadherin 1, type 1, E-cadherin (epithelial)	11.0

Pathways related to gastric cancer, somatic according to GeneDecks:

(show all 13)

id	Pathway	Score	Top Affiliating Genes
1	Development EGFR signaling via PIP310	10.0	PIK3CA
2	Development FGF-family signaling10	9.7	FGFR2
3	Presenilin-Mediated Signaling36	9.3	CDH1, CASP10, APC
4	Molecular Mechanisms of Cancer36	9.2	APC, CDH1, FGFR2
5	Development_EGFR signaling via PIP341	9.1	PIK3CA, ERBB2
6	Endothelin-1 Signaling Pathway36	8.8	ERBB2, CASP10, FGFR2
7	Regulation of actin cytoskeleton20	8.8	PIK3CA, APC, FGFR2
8	CDC42 Pathway36	8.8	CDH1, FGFR2, ERBB2
9	Prostate cancer20	8.7	ERBB2, FGFR2, PIK3CA
10	Nanog in Mammalian ESC Pluripotency36	8.7	FGFR2, APC, ERBB2
11	GSK3 Signaling36	8.4	CDH1, FGFR2, APC, ERBB2
12	Endometrial cancer20	8.3	ERBB2, APC, CDH1, PIK3CA
13	Pathways in cancer20	8.2	ERBB2, FGFR2, CDH1, PIK3CA

Compounds related to gastric cancer, somatic according to GeneDecks:

(show all 46)

id	Compound	Score	Top Affiliating Genes
1	paraffin32	10.3	APC
2	af/ap32	10.0	APC, MUTYH
3	8-oxoguanine32	9.8	MUTYH, APC
4	exisulind32	9.8	APC, CDH1
5	sodium bisulfite32	9.7	CDH1, APC
6	5-methylcytosine32 18	10.6	CDH1, APC
7	h2o232	9.5	MUTYH, FGFR2
8	pki-16632	9.5	CDH1, ERBB2
9	arginine32	9.4	ERBB2, PIK3CA
10	crcs32	9.3	CDH1, APC, PIK3CA
11	5-methylthioadenosine32	9.2	FGFR2, ERBB2
12	o6-methylguanine32	9.2	APC, CDH1
13	5-aza-2deoxycytidine32	9.2	FGFR2, CDH1, APC
14	suberoylanilide hydroxamic acid32	9.2	CDH1, IRF1, ERBB2
15	adenine32 9 18 9	12.1	CDH1, IRF1, APC, MUTYH
16	celecoxib32 42 34 9 18 9	14.0	ERBB2, CDH1, APC
17	adriamycin32	9.0	IRF1, CDH1, ERBB2
18	erlotinib32 34 9 9	11.9	PIK3CA, CDH1, ERBB2
19	curcumin32	8.9	ERBB2, APC, CDH1
20	trastuzumab32 34 9 9	11.9	PIK3CA, ERBB2, FGFR2
21	gefitinib32 34 9 9	11.9	PIK3CA, ERBB2, CDH1
22	folate32	8.9	APC, CDH1, ERBB2
23	guanine32 9 18 9	11.7	ERBB2, MUTYH, FGFR2, APC
24	epinephrine32 9 18 9	11.7	APC, FGFR2, ERBB2
25	aspirin32 34 18	10.6	ERBB2, APC, CDH1
26	vitamin d32	8.5	CDH1, FGFR2, APC, ERBB2
27	etoposide32 42 9 9	11.5	IRF1, CDH1, PIK3CA, ERBB2
28	5fluorouracil32	8.4	PIK3CA, CDH1, ERBB2, FGFR2
29	wortmannin32 42	9.4	APC, CDH1, PIK3CA, ERBB2
30	agar32	8.4	CDH1, FGFR2, ERBB2, PIK3CA
31	phosphotyrosine32	8.4	ERBB2, FGFR2, CDH1, PIK3CA
32	doxorubicin32 34 9 9	11.3	CDH1, ERBB2, FGFR2, PIK3CA
33	genistein32 9 18 9	11.3	ERBB2, FGFR2, PIK3CA, CDH1
34	retinoic acid32 42 18	10.3	APC, IRF1, FGFR2, CDH1, PIK3CA
35	cisplatin32 34 9 9	11.3	CDH1, FGFR2, ERBB2, PIK3CA
36	adenylate32	8.1	CDH1, IRF1, FGFR2, APC, PIK3CA, KLF6
37	paclitaxel32 34 9 9	11.1	ERBB2, CASP10, PIK3CA, FGFR2, CDH1
38	adp32 18	9.1	PIK3CA, KLF6, APC, FGFR2, ERBB2
39	tamoxifen32 34 9 9	11.0	ERBB2, PIK3CA, CDH1, IRF1, FGFR2
40	heparin32 9 18 9	10.9	FGFR2, CDH1, ERBB2, APC, PIK3CA
41	progesterone32 42 9 18 9	11.9	PIK3CA, ERBB2, APC, FGFR2, CDH1
42	testosterone32 9 18 9	10.9	PIK3CA, FGFR2, CDH1, APC, ERBB2
43	phosphatidylinositol32	7.6	FGFR2, APC, ERBB2, IRF1, PIK3CA, CDH1
44	tyrosine32	7.5	IRF1, CDH1, FGFR2, APC, ERBB2, PIK3CA
45	estrogen32	7.3	PIK3CA, ERBB2, KLF6, CDH1, IRF1, FGFR2
46	serine32	6.9	FGFR2, PIK3CA, KLF6, CDH1, IRF1, APC

Cellular components related to gastric cancer, somatic according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	lateral plasma membrane	GO:016328	9.5	CDH1, APC
2	cell-cell adherens junction	GO:005913	9.2	CDH1, APC

Biological processes related to gastric cancer, somatic according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of osteoblast differentiation	GO:045667	9.6	FGFR2, APC
2	tight junction assembly	GO:070830	9.4	CDH1, APC
3	regulation of microtubule-based process	GO:032886	9.3	APC, ERBB2
4	regulation of multicellular organism growth	GO:040014	9.3	PIK3CA, FGFR2
5	regulation of ERK1 and ERK2 cascade	GO:070372	9.2	ERBB2, FGFR2
6	positive regulation of cell adhesion	GO:045785	8.9	APC, ERBB2
7	apoptotic process	GO:006915	8.6	CASP10, APC, FGFR2, CDH1

Molecular functions related to gastric cancer, somatic according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	gamma-catenin binding	GO:045295	9.2	APC, CDH1
2	protein binding	GO:005515	6.4	ERBB2, CASP10, APC, FGFR2, IRF1, CDH1