MCID: GST060
MIFTS: 45

Gastric Cancer, Somatic malady

Genetic diseases (common), Cancer diseases, Gastrointestinal diseases categories

Aliases & Classifications for Gastric Cancer, Somatic

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Gastric Cancer, Somatic, Aliases & Descriptions:

Name: Gastric Cancer, Somatic 45 10
Gastric Cancer 30 43
Gastric Cancer Gastric Cancer, Intestinal, Included 45
 
Malignant Neoplasm of Stomach 60
Stomach Carcinoma 60


Classifications:



External Ids:

OMIM45 613659
ICD1025 C16

Summaries for Gastric Cancer, Somatic

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OMIM:45 In a review article on the genetic predisposition to gastric cancer, Bevan and Houlston (1999) concluded that several... (613659) more...

MalaCards based summary: Gastric Cancer, Somatic, also known as gastric cancer, is related to stomach cancer and breast cancer, and has symptoms including somatic mutationand stomach cancer. An important gene associated with Gastric Cancer, Somatic is FGFR2 (fibroblast growth factor receptor 2), and among its related pathways are Alzheimers Disease Pathway and EGFR Signaling Pathway. The compounds 5-methylthioadenosine and regorafenib have been mentioned in the context of this disorder. Affiliated tissues include colon, and related mouse phenotypes are pigmentation and limbs/digits/tail.

Related Diseases for Gastric Cancer, Somatic

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Diseases related to Gastric Cancer, Somatic via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 234)
idRelated DiseaseScoreTop Affiliating Genes
1stomach cancer31.3ERBB2
2breast cancer30.7KRAS, PIK3CA
3colorectal cancer30.2APC, PIK3CA, KRAS
4gastric adenocarcinoma30.1PIK3CA, KRAS, APC, ERBB2
5lynch syndrome30.0MUTYH, KRAS, APC
6pancreatic cancer29.9ERBB2, KRAS, FGFR2, PIK3CA
7leukemia29.8IRF1, CASP10, PIK3CA, KRAS, FGFR2
8melanoma29.8KRAS, FGFR2, CASP10, IRF1, PIK3CA
9lung cancer29.7ERBB2, KRAS, PIK3CA
10adenocarcinoma29.7ERBB2, IRF1, PIK3CA, APC, KLF6, KRAS
11cholangiocarcinoma29.7PIK3CA, ERBB2, KRAS
12adenomatous polyposis coli29.5KRAS, IRF1, MUTYH, APC
13prostate cancer29.1KRAS, FGFR2, PIK3CA, APC, KLF6, ERBB2
14retinoblastoma28.9KRAS, IRF1, FGFR2, KLF6, ERBB2, PIK3CA
15hepatocellular carcinoma28.8MUTYH, KRAS, FGFR2, KLF6, IRF1, PIK3CA
16diffuse gastric cancer11.0
17peritonitis11.0
18gastritis11.0
19endotheliitis10.9
20atrophic gastritis10.8
21duodenitis10.7
22hypoxia10.7
23familial gastric cancer10.7
24esophagitis10.7
25h. pylori infection10.7
26duodenal ulcer10.6
27gastric ulcer10.5
28pancreatitis10.5
29peptic ulcer disease10.5
30prostatitis10.5
31hepatitis10.4
32gastric outlet obstruction10.4
33disseminated intravascular coagulation10.4
34microinvasive gastric cancer10.4
35cronkhite-canada syndrome10.4
36intestinal neoplasm10.3APC
37esophageal cancer10.3
38li-fraumeni syndrome10.3
39situs inversus10.3
40ataxia-telangiectasia10.3
41malt lymphoma10.3
42gastric lymphoma10.3
43linitis plastica10.3
44adenoma10.3
45pyloric stenosis10.3
46thyroiditis10.3
47ataxia10.3
48thrombocytosis10.2
49cardia cancer10.2
50obstructive jaundice10.2

Graphical network of the top 20 diseases related to Gastric Cancer, Somatic:



Diseases related to gastric cancer, somatic

Symptoms for Gastric Cancer, Somatic

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Clinical features from OMIM:

613659

HPO human phenotypes related to Gastric Cancer, Somatic:

id Description Frequency HPO Source Accession
1 somatic mutation HP:0001428
2 stomach cancer HP:0012126

Drugs & Therapeutics for Gastric Cancer, Somatic

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Drug clinical trials:

Search ClinicalTrials for Gastric Cancer, Somatic

Search NIH Clinical Center for Gastric Cancer, Somatic

Genetic Tests for Gastric Cancer, Somatic

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Anatomical Context for Gastric Cancer, Somatic

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MalaCards organs/tissues related to Gastric Cancer, Somatic:

31
Colon

Animal Models for Gastric Cancer, Somatic or affiliated genes

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MGI Mouse Phenotypes related to Gastric Cancer, Somatic:

35 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.1APC, FGFR2, KRAS
2MP:00053718.8FGFR2, KRAS, ERBB2, APC
3MP:00053708.8APC, KLF6, KRAS, FGFR2
4MP:00053678.7FGFR2, KRAS, IRF1, APC
5MP:00053818.6FGFR2, ERBB2, APC, KRAS
6MP:00028738.4IRF1, FGFR2, KRAS, ERBB2, APC
7MP:00053918.2PIK3CA, KRAS, FGFR2, APC
8MP:00053978.1FGFR2, KRAS, IRF1, APC, KLF6
9MP:00053698.1ERBB2, KRAS, APC, FGFR2, PIK3CA
10MP:00053797.8PIK3CA, FGFR2, KRAS, KLF6, APC, ERBB2
11MP:00053807.8APC, FGFR2, KRAS, ERBB2, KLF6, PIK3CA
12MP:00053897.7PIK3CA, APC, ERBB2, KLF6, KRAS, FGFR2
13MP:00053787.7PIK3CA, APC, ERBB2, KLF6, KRAS, FGFR2
14MP:00036317.5FGFR2, KRAS, ERBB2, PIK3CA, MUTYH, APC
15MP:00053867.5APC, ERBB2, PIK3CA, KRAS, FGFR2
16MP:00107717.3PIK3CA, KLF6, FGFR2, KRAS, APC, IRF1
17MP:00053857.3PIK3CA, APC, IRF1, ERBB2, FGFR2, KRAS
18MP:00020067.2PIK3CA, MUTYH, APC, ERBB2, KRAS, IRF1
19MP:00053767.1IRF1, ERBB2, KRAS, APC, PIK3CA, FGFR2
20MP:00053846.8FGFR2, KRAS, KLF6, ERBB2, PIK3CA, MUTYH
21MP:00107686.8ERBB2, MUTYH, FGFR2, KRAS, KLF6, IRF1

Publications for Gastric Cancer, Somatic

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Variations for Gastric Cancer, Somatic

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UniProtKB/Swiss-Prot genetic disease variations for Gastric Cancer, Somatic:

62 (show all 20)
id Symbol AA change Variation ID SNP ID
1APCp.Gly817CysVAR_005035
2APCp.Ile880ThrVAR_005036
3APCp.Asn942AspVAR_005039
4APCp.Gly1120GluVAR_005042rs28933379
5APCp.Arg1171HisVAR_005043
6APCp.Phe1197SerVAR_005045
7APCp.Ile1259ThrVAR_005046
8APCp.Gly1312GluVAR_005050
9APCp.Val1326AlaVAR_005052
10CASP10p.Met147ThrVAR_037428rs121909776
11IRF1p.Met8LeuVAR_065134
12IRF1p.Trp11ArgVAR_065135
13KRASp.Gly12ValVAR_006840
14KRASp.Gly12AspVAR_016026
15KRASp.Gly12SerVAR_016028
16KRASp.Gly13AspVAR_016029
17KRASp.Ala59ThrVAR_016030
18KRASp.Lys5AsnVAR_064849
19MUTYHp.Pro402SerVAR_026049
20MUTYHp.Gln411ArgVAR_026050

Clinvar genetic disease variations for Gastric Cancer, Somatic:

6 (show all 15)
id Gene Variation Type Significance SNP ID Assembly Location
1KRASNM_033360.3(KRAS): c.35G> A (p.Gly12Asp)single nucleotide variantPathogenic, drug responsers121913529GRCh37Chr 12, 25398284: 25398284
2KRASNM_033360.3(KRAS): c.34G> A (p.Gly12Ser)single nucleotide variantPathogenic, drug responsers121913530GRCh37Chr 12, 25398285: 25398285
3FGFR2NM_000141.4(FGFR2): c.799T> C (p.Ser267Pro)single nucleotide variantPathogenicrs121918505GRCh37Chr 10, 123279633: 123279633
4PIK3CANM_006218.2(PIK3CA): c.3140A> G (p.His1047Arg)single nucleotide variantPathogenicrs121913279GRCh37Chr 3, 178952085: 178952085
5PIK3CANM_006218.2(PIK3CA): c.1633G> A (p.Glu545Lys)single nucleotide variantPathogenicrs104886003GRCh37Chr 3, 178936091: 178936091
6PIK3CANM_006218.2(PIK3CA): c.3203dupA (p.Asn1068Lysfs)duplicationPathogenicGRCh37Chr 3, 178952148: 178952148
7ERBB2NM_001005862.2(ERBB2): c.2236G> A (p.Gly746Ser)single nucleotide variantPathogenicrs28933369GRCh37Chr 17, 37880997: 37880997
8IRF1NM_002198.2(IRF1): c.22A> T (p.Met8Leu)single nucleotide variantPathogenicrs121912469GRCh37Chr 5, 131825149: 131825149
9MUTYHNM_001128425.1(MUTYH): c.1213C> T (p.Pro405Ser)single nucleotide variantPathogenicrs121908382GRCh37Chr 1, 45797202: 45797202
10MUTYHNM_001128425.1(MUTYH): c.1241A> G (p.Gln414Arg)single nucleotide variantPathogenicrs121908383GRCh37Chr 1, 45797174: 45797174
11KLF6NM_001300.5(KLF6): c.465C> A (p.Ser155Arg)single nucleotide variantPathogenicrs121909144GRCh37Chr 10, 3824044: 3824044
12CASP10NM_032977.3(CASP10): c.769C> T (p.Gln257Ter)single nucleotide variantPathogenicrs121909775GRCh37Chr 2, 202070652: 202070652
13CASP10NM_032977.3(CASP10): c.440T> C (p.Met147Thr)single nucleotide variantPathogenicrs121909776GRCh37Chr 2, 202052521: 202052521
14APCNM_000038.5(APC): c.3359G> A (p.Gly1120Glu)single nucleotide variantPathogenicrs28933379GRCh37Chr 5, 112174650: 112174650
15APCNM_000038.5(APC): c.3199C> T (p.Gln1067Ter)single nucleotide variantPathogenicrs137854571GRCh37Chr 5, 112174490: 112174490

Expression for genes affiliated with Gastric Cancer, Somatic

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Search GEO for disease gene expression data for Gastric Cancer, Somatic.

Pathways for genes affiliated with Gastric Cancer, Somatic

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Pathways related to Gastric Cancer, Somatic according to GeneCards Suite gene sharing:

(show all 50)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8FGFR2, ERBB2
29.7ERBB2, CASP10
3
Show member pathways
9.6KRAS, FGFR2
4
Show member pathways
9.6KRAS, ERBB2
5
Show member pathways
Angiogenesis36
9.3PIK3CA, FGFR2
69.3FGFR2, PIK3CA
79.3PIK3CA, ERBB2
89.3PIK3CA, ERBB2
9
Show member pathways
9.3PIK3CA, ERBB2
109.3ERBB2, KRAS, FGFR2
11
Show member pathways
TRAIL signaling pathway36
9.2PIK3CA, CASP10
129.2IRF1, PIK3CA
13
Show member pathways
IFN-gamma pathway36
9.2IRF1, PIK3CA
149.1KRAS, PIK3CA
159.1PIK3CA, KRAS
169.1PIK3CA, KRAS
179.0PIK3CA, APC
189.0PIK3CA, APC
19
Show member pathways
8.8KRAS, FGFR2, PIK3CA
20
Show member pathways
8.8PIK3CA, KRAS, FGFR2
21
Show member pathways
8.8PIK3CA, KRAS, FGFR2
22
Show member pathways
8.8FGFR2, KRAS, PIK3CA
238.8FGFR2, KRAS, PIK3CA
24
Show member pathways
ErbB receptor signaling network36
ErbB signaling pathway36
8.8KRAS, PIK3CA, ERBB2
25
Show member pathways
Transcription Receptor mediated HIF regulation58
Development CNTF receptor signaling58
Class IB PI3K non-lipid kinase events36
ErbB2/ErbB3 signaling events36
Development Growth hormone signaling via PI3K AKT and MAPK cascades58
Translation Regulation activity of EIF258
Regulation of lipid metabolism Insulin signaling generic cascades58
Transcription PPAR Pathway58
Cell adhesion PLAU signaling58
Translation Regulation activity of EIF4F58
8.8KRAS, PIK3CA, ERBB2
26
Show member pathways
8.8ERBB2, PIK3CA, KRAS
278.8ERBB2, PIK3CA, KRAS
28
Show member pathways
Development EGFR signaling via PIP358
Development PDGF signaling via MAPK cascades58
Apoptosis and survival Anti apoptotic action of membrane bound ESR158
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases58
Development Neurotrophin family signaling58
Apoptosis and survival NGF signaling pathway58
Apoptosis and survival Role of CDK5 in neuronal death and survival58
8.8ERBB2, PIK3CA, KRAS
29
Show member pathways
8.7APC, CASP10, ERBB2, FGFR2
30
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.7CASP10, PIK3CA, KRAS
318.7PIK3CA, IRF1, KRAS
32
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes58
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway58
8.7KRAS, IRF1, PIK3CA
33
Show member pathways
8.7IRF1, KRAS, PIK3CA
348.5KRAS, APC, PIK3CA
35
Show member pathways
Signaling Pathways in Glioblastoma36
8.4KRAS, PIK3CA, FGFR2, ERBB2
368.4KRAS, PIK3CA, FGFR2, ERBB2
37
Show member pathways
8.4KRAS, FGFR2, ERBB2, PIK3CA
38
Show member pathways
8.4FGFR2, ERBB2, KRAS, PIK3CA
39
Show member pathways
8.4FGFR2, PIK3CA, ERBB2, KRAS
40
Show member pathways
8.4FGFR2, KRAS, ERBB2, PIK3CA
41
Show member pathways
8.4CASP10, FGFR2, PIK3CA, KRAS
42
Show member pathways
Prolactin Signaling Pathway36
Development Prolactin receptor signaling58
Leptin signaling pathway36
8.3PIK3CA, ERBB2, IRF1, KRAS
43
Show member pathways
8.2KRAS, PIK3CA, FGFR2, APC
448.1APC, PIK3CA, KRAS, ERBB2
45
Show member pathways
Signal transduction PTEN pathway58
8.1PIK3CA, APC, ERBB2, KRAS
46
Show member pathways
8.0PIK3CA, ERBB2, KRAS, CASP10, FGFR2
47
Show member pathways
7.8ERBB2, PIK3CA, APC, FGFR2, KRAS
487.8APC, PIK3CA, ERBB2, FGFR2, KRAS
497.7APC, PIK3CA, CASP10, ERBB2, KRAS

Compounds for genes affiliated with Gastric Cancer, Somatic

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Compounds related to Gastric Cancer, Somatic according to GeneCards Suite gene sharing:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
15-methylthioadenosine4310.1FGFR2, ERBB2
2regorafenib49 1210.9FGFR2, KRAS
3cetuximab43 49 1211.8KRAS, ERBB2
4af/ap439.8MUTYH, APC
58-oxoguanine439.7APC, MUTYH
6everolimus43 49 1211.6ERBB2, PIK3CA
7cyclophosphamide43 49 1211.6FGFR2, ERBB2, MUTYH
8suberoylanilide hydroxamic acid439.5IRF1, ERBB2
9o6-methylguanine439.5APC, KRAS
10epinephrine43 24 1211.4APC, ERBB2, FGFR2
11trastuzumab43 49 1211.4PIK3CA, ERBB2, FGFR2
12agar439.3PIK3CA, ERBB2, FGFR2
13adenine43 24 1211.2IRF1, MUTYH, APC
14pertussis439.2FGFR2, APC
15phosphotyrosine439.2FGFR2, ERBB2, PIK3CA
16erlotinib43 49 1211.2PIK3CA, ERBB2, KRAS
17gefitinib43 49 1211.2KRAS, ERBB2, PIK3CA
18imatinib43 49 1211.1PIK3CA, ERBB2, KRAS
19guanine43 24 1211.1FGFR2, ERBB2, MUTYH, APC
20etoposide43 49 59 1212.1PIK3CA, IRF1, ERBB2
21vitamin d439.1APC, ERBB2, KRAS, FGFR2
22doxorubicin43 49 1211.0PIK3CA, ERBB2, FGFR2
23paraffin439.0FGFR2, KRAS, ERBB2, APC
24crcs438.9KRAS, APC, PIK3CA
25tamoxifen43 49 28 1211.9FGFR2, ERBB2, IRF1, PIK3CA
26oligonucleotide438.9APC, IRF1, KRAS, FGFR2
27ly294002438.9KRAS, ERBB2, PIK3CA
285fluorouracil438.9PIK3CA, ERBB2, KRAS, FGFR2
29nitric oxide43 24 1210.8FGFR2, KLF6, IRF1, PIK3CA
30oxygen43 249.8MUTYH, IRF1, KRAS, FGFR2
31arginine438.8PIK3CA, IRF1, ERBB2, FGFR2
32actinomycin d438.8CASP10, IRF1, PIK3CA
33vegf438.8FGFR2, KRAS, ERBB2, PIK3CA
34heparin43 28 24 1211.7PIK3CA, APC, ERBB2, FGFR2
35progesterone43 28 59 24 1212.7PIK3CA, APC, ERBB2, FGFR2
36testosterone43 59 24 1211.7PIK3CA, APC, ERBB2, FGFR2
37wortmannin438.5PIK3CA, APC, ERBB2, KRAS
38phosphoinositide438.5KRAS, APC, PIK3CA
39paclitaxel43 49 1210.5PIK3CA, CASP10, ERBB2, KRAS, FGFR2
40adp43 28 2410.4FGFR2, KLF6, ERBB2, APC, PIK3CA
41h2o2438.3PIK3CA, MUTYH, ERBB2, KRAS, FGFR2
42adenylate438.3PIK3CA, APC, IRF1, KLF6, FGFR2
43rapamycin438.3PIK3CA, APC, ERBB2, KRAS, FGFR2
44retinoic acid43 249.1PIK3CA, APC, IRF1, KRAS, FGFR2
45lipid438.1PIK3CA, APC, IRF1, KRAS, FGFR2
46cisplatin43 49 59 1211.0PIK3CA, MUTYH, CASP10, ERBB2, KRAS, FGFR2
47phosphatidylinositol437.8PIK3CA, APC, IRF1, ERBB2, KRAS, FGFR2
48tyrosine437.8PIK3CA, APC, IRF1, ERBB2, KRAS, FGFR2
49estrogen437.5PIK3CA, APC, IRF1, ERBB2, KLF6, KRAS
50serine437.1FGFR2, PIK3CA, APC, IRF1, CASP10, ERBB2

GO Terms for genes affiliated with Gastric Cancer, Somatic

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Cellular components related to Gastric Cancer, Somatic according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00057377.9APC, IRF1, CASP10, ERBB2, KLF6, FGFR2
2plasma membraneGO:00058867.1PIK3CA, APC, CASP10, ERBB2, KRAS, FGFR2

Biological processes related to Gastric Cancer, Somatic according to GeneCards Suite gene sharing:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1regulation of ERK1 and ERK2 cascadeGO:007037210.1FGFR2, ERBB2
2neuromuscular junction developmentGO:00075289.9FGFR2, ERBB2
3regulation of osteoblast differentiationGO:00456679.8APC, FGFR2
4regulation of microtubule-based processGO:00328869.7APC, ERBB2
5positive regulation of epithelial cell proliferationGO:00506799.7FGFR2, ERBB2
6positive regulation of MAP kinase activityGO:00434069.6KRAS, ERBB2
7positive regulation of cell adhesionGO:00457859.6APC, ERBB2
8positive regulation of cell divisionGO:00517819.5FGFR2, APC
9axonogenesisGO:00074099.5FGFR2, APC
10regulation of multicellular organism growthGO:00400149.5PIK3CA, FGFR2
11cytokine-mediated signaling pathwayGO:00192219.4KRAS, KLF6, IRF1
12phosphatidylinositol-mediated signalingGO:00480159.2FGFR2, ERBB2, PIK3CA
13insulin receptor signaling pathwayGO:00082869.0FGFR2, KRAS, PIK3CA
14apoptotic processGO:00069158.9APC, FGFR2, CASP10, IRF1
15fibroblast growth factor receptor signaling pathwayGO:00085438.8PIK3CA, ERBB2, KRAS, FGFR2
16Fc-epsilon receptor signaling pathwayGO:00380958.8FGFR2, ERBB2, PIK3CA, KRAS
17epidermal growth factor receptor signaling pathwayGO:00071738.8PIK3CA, ERBB2, FGFR2, KRAS
18neurotrophin TRK receptor signaling pathwayGO:00480118.7ERBB2, PIK3CA, KRAS, FGFR2
19blood coagulationGO:00075968.4IRF1, PIK3CA, KRAS
20innate immune responseGO:00450878.3FGFR2, KRAS, PIK3CA, CASP10, ERBB2

Molecular functions related to Gastric Cancer, Somatic according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00055156.4FGFR2, KRAS, ERBB2, CASP10, IRF1, MUTYH

Products for genes affiliated with Gastric Cancer, Somatic

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Sources for Gastric Cancer, Somatic

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet