MCID: GST006
MIFTS: 32

Gastric Leiomyoma

Categories: Gastrointestinal diseases, Cancer diseases

Aliases & Classifications for Gastric Leiomyoma

MalaCards integrated aliases for Gastric Leiomyoma:

Name: Gastric Leiomyoma 12 14 69
Leiomyoma of the Stomach 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10087
NCIt 46 C3876
SNOMED-CT 64 276812001
UMLS 69 C0238440

Summaries for Gastric Leiomyoma

MalaCards based summary : Gastric Leiomyoma, also known as leiomyoma of the stomach, is related to paraganglioma and leiomyoma. An important gene associated with Gastric Leiomyoma is FH (Fumarate Hydratase), and among its related pathways/superpathways are Pathways in cancer and Chks in Checkpoint Regulation. Affiliated tissues include pituitary, thyroid and liver, and related phenotype is Increased viability with MLN4924 (a NAE inhibitor).

Related Diseases for Gastric Leiomyoma

Diseases related to Gastric Leiomyoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 paraganglioma 29.6 CHGA FH
2 leiomyoma 10.6
3 papillary ependymoma 10.1 CHGA KRT18
4 pleomorphic xanthoastrocytoma 10.1 CHGA MGMT
5 anal squamous cell carcinoma 10.1 MGMT MLH1
6 appendix carcinoid tumor 10.1 MLH1 MSH6
7 adenosquamous colon carcinoma 10.0 MLH1 MSH6
8 glycogen storage disease vi 10.0 CHGA GCG
9 sebaceous adenoma 10.0 MLH1 MSH6
10 lynch syndrome i 10.0 MLH1 MSH6
11 sebaceous adenocarcinoma 10.0 MLH1 MSH6
12 small intestine cancer 10.0 MLH1 MSH6
13 skin sarcoma 10.0 CALD1 FH
14 muir-torre syndrome 9.9 MLH1 MSH6
15 skin benign neoplasm 9.9 MLH1 MSH6
16 hereditary breast ovarian cancer syndrome 9.9 MLH1 MSH6
17 colorectal adenoma 9.9 MGMT MLH1
18 mismatch repair cancer syndrome 9.9 MLH1 MSH6
19 nephrogenic adenofibroma 9.9 CALD1 KRT18
20 adenoma 9.8
21 cell type benign neoplasm 9.8 CHGA FH MLH1
22 colorectal adenocarcinoma 9.8 MLH1 MSH6
23 familial adenomatous polyposis 9.7 MGMT MLH1 MSH6
24 female reproductive organ cancer 9.7 MLH1 MSH6
25 intussusception 9.7
26 paragangliomas 1 9.7
27 thyroid cancer, nonmedullary, 1 9.7
28 gallbladder disease 1 9.7
29 esophagitis 9.7
30 leiomyosarcoma 9.7
31 pituitary adenoma 9.7
32 pancreatitis 9.7
33 leiomyomatosis 9.7
34 multicentric papillary thyroid carcinoma 9.7
35 thyroiditis 9.7
36 mediastinitis 9.7
37 duodenitis 9.7
38 gastroduodenitis 9.7
39 amyloidosis 9.7
40 pancreatic adenoma 9.7
41 multiple endocrine neoplasia 9.7
42 cecum adenocarcinoma 9.7 CHGA MLH1 MSH6
43 gastric adenocarcinoma 9.7 CHGA MGMT MLH1
44 endocrine gland cancer 9.6 CHGA GCG MLH1
45 autosomal genetic disease 9.6 MLH1 MSH6
46 lynch syndrome 9.5 MGMT MLH1 MSH3 MSH6

Graphical network of the top 20 diseases related to Gastric Leiomyoma:



Diseases related to Gastric Leiomyoma

Symptoms & Phenotypes for Gastric Leiomyoma

GenomeRNAi Phenotypes related to Gastric Leiomyoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 8.92 MGMT MLH1 MSH3 MSH6

Drugs & Therapeutics for Gastric Leiomyoma

Search Clinical Trials , NIH Clinical Center for Gastric Leiomyoma

Genetic Tests for Gastric Leiomyoma

Anatomical Context for Gastric Leiomyoma

MalaCards organs/tissues related to Gastric Leiomyoma:

38
Pituitary, Thyroid, Liver

Publications for Gastric Leiomyoma

Articles related to Gastric Leiomyoma:

(show top 50) (show all 78)
# Title Authors Year
1
Intragastric Single-Incision Laparoscopic Surgery for Gastric Leiomyoma: A Stepwise Approach. ( 28466402 )
2017
2
Endoscopic dissection of a symptomatic giant gastric leiomyoma arising from the muscularis propria. ( 28355652 )
2017
3
Laparoscopic Transgastric Enucleation of a Gastric Leiomyoma near the Esophagogastric Junction and Concomitant Sleeve Gastrectomy: Video Report. ( 26883931 )
2016
4
Partial gastrectomy for resection of a gastric leiomyoma in a guinea pig (Cavia porcellus). ( 27901456 )
2016
5
Gastric leiomyoma in a child with Gorlin-Goltz syndrome: First pediatric case. ( 26567923 )
2015
6
Laparoscopic-Assisted Endoscopic Resection of a Gastric Leiomyoma. ( 25642406 )
2014
7
Epigenetic alterations in a gastric leiomyoma. ( 25544907 )
2014
8
Intragastric endoscopic assisted single incision surgery for gastric leiomyoma of the esophagogastric junction. ( 24416603 )
2013
9
Gastric leiomyoma and hyperplastic polyposis coli in a patient with multiple cutaneous and uterine leiomyomatosis. ( 22713448 )
2012
10
Robotic-assisted laparoscopic wedge resection of a gastric leiomyoma with intraoperative ultrasound localization. ( 21919811 )
2011
11
Gastric leiomyoma in a free-living Atlantic bottlenosed dolphin (Tursiops truncatus). ( 17259457 )
2007
12
Laparoscopic wedge resection of gastric leiomyoma. ( 17212898 )
2006
13
Laparoscopic wedge resection of gastric leiomyoma. ( 14974670 )
2004
14
Gastric leiomyoma. Is there an association with Helicobacter pylori? ( 15573227 )
2004
15
Symptomatic gastric leiomyoma mimicking giant gastric polyp: endoscopic diagnosis and removal. ( 15368793 )
2004
16
Gastric leiomyoma presenting as gastric volvulus. ( 15030039 )
2003
17
Laparoscopic intragastric resection of gastric leiomyoma using needlescopic instruments. Case report. ( 11409411 )
2001
18
Laparoscopic wedge resection of a gastric leiomyoma. ( 11443434 )
2001
19
Surgical treatment of gastric leiomyoma in a dog. ( 10197242 )
1999
20
An undescribed coexistence of a subserosal exophytic gastric leiomyoma with a serous microcystic pancreatic adenoma. ( 10670168 )
1999
21
Laparoscopic intragastric resection of gastric leiomyoma close to the cardia using a flexible endocutter intraluminally. ( 10636561 )
1999
22
Gastroduodenal intussusception secondary to a gastric leiomyoma resulting in an ulceration. ( 10344450 )
1999
23
Posterior wall gastric leiomyoma: endoscopic tattooing facilitates laparoscopic resection. ( 9876718 )
1998
24
Combined laparoscopic treatment of gastric leiomyoma and gallstones. ( 9830549 )
1998
25
Laparoscopic management of a gastric perforation after snare removal of a gastric leiomyoma. ( 9689521 )
1998
26
Cystic gastric leiomyoma--a diagnostic pitfall. ( 9396182 )
1997
27
Resection of a gastric leiomyoma using combined laparoscopic and gastroscopic approach. ( 9079612 )
1997
28
Laparoscopic intragastric surgery for gastric leiomyoma. ( 9079613 )
1997
29
Laparoscopic resection of posterior gastric leiomyoma. ( 9079609 )
1997
30
Calcified gastric leiomyoma: a rare cause of calcification in the abdomen. ( 8583116 )
1995
31
Ossified gastric leiomyoma in a child: a case report. ( 7761163 )
1995
32
Combined laparoscopic and endoscopic approach to resection of gastric leiomyoma. ( 7612942 )
1995
33
Laparoscopic gastric resection for gastric leiomyoma. ( 7992156 )
1994
34
Endoscopic closure of a perforation using metallic clips after snare excision of a gastric leiomyoma. ( 8495838 )
1993
35
Kinking of splenic artery mimicking gastric leiomyoma. ( 8262001 )
1993
36
Case report: simple liver cyst masquerading as a gastric leiomyoma--a diagnostic pitfall. ( 8243013 )
1993
37
Large polypoid gastric leiomyoma with intermittent duodenal prolapse. ( 8253656 )
1993
38
Injection therapy for bleeding gastric leiomyoma. ( 1473688 )
1992
39
Gastric leiomyoma: an unusual presentation. ( 1561201 )
1992
40
Leiomyomatous tumors: presentation of a giant gastric leiomyoma and a review of the literature. ( 2668809 )
1989
41
Enucleation of a gastric leiomyoma by a combined laser and snare electrocutting technique. ( 3366329 )
1988
42
Technetium-99m labeled RBC imaging in gastrointestinal bleeding from gastric leiomyoma. ( 3258215 )
1988
43
Drug-induced bleeding of gastric leiomyoma. ( 3495170 )
1987
44
Gastric leiomyoma presenting with intraperitoneal haemorrhage. ( 3487681 )
1986
45
Gastric leiomyoma and its manifestations in Nigerians. A series of 10 patients. ( 3093727 )
1986
46
Gastric leiomyoma and its manifestations in Nigerians: a series of 10 patients. ( 3488812 )
1986
47
Complete healing of ulceration within a gastric leiomyoma. ( 3871713 )
1985
48
Esophageal/gastric leiomyoma in the laboratory Beagle. ( 6605959 )
1983
49
A simple and safe technique for the local excision of gastric leiomyoma using staples. ( 7137332 )
1982
50
Multiple endocrine neoplasia. Pituitary adenoma, multicentric papillary thyroid carcinoma, bilateral carotid body paraganglioma, parathyroid hyperplasia, gastric leiomyoma, and systemic amyloidosis. ( 7137085 )
1982

Variations for Gastric Leiomyoma

Expression for Gastric Leiomyoma

Search GEO for disease gene expression data for Gastric Leiomyoma.

Pathways for Gastric Leiomyoma

GO Terms for Gastric Leiomyoma

Biological processes related to Gastric Leiomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.76 MGMT MLH1 MSH3 MSH6
2 DNA repair GO:0006281 9.67 MGMT MLH1 MSH3 MSH6
3 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.48 MLH1 MSH6
4 somatic hypermutation of immunoglobulin genes GO:0016446 9.43 MLH1 MSH6
5 isotype switching GO:0045190 9.4 MLH1 MSH6
6 positive regulation of helicase activity GO:0051096 9.32 MSH3 MSH6
7 negative regulation of DNA recombination GO:0045910 9.26 MSH3 MSH6
8 maintenance of DNA repeat elements GO:0043570 9.16 MSH3 MSH6
9 mismatch repair GO:0006298 9.13 MLH1 MSH3 MSH6
10 somatic recombination of immunoglobulin gene segments GO:0016447 8.8 MLH1 MSH3 MSH6

Molecular functions related to Gastric Leiomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 damaged DNA binding GO:0003684 9.37 MSH3 MSH6
2 DNA-dependent ATPase activity GO:0008094 9.32 MSH3 MSH6
3 oxidized purine DNA binding GO:0032357 9.26 MSH3 MSH6
4 single guanine insertion binding GO:0032142 9.16 MSH3 MSH6
5 mismatched DNA binding GO:0030983 9.13 MLH1 MSH3 MSH6
6 guanine/thymine mispair binding GO:0032137 8.8 MLH1 MSH3 MSH6

Sources for Gastric Leiomyoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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