MCID: GST006
MIFTS: 31

Gastric Leiomyoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Gastric Leiomyoma

MalaCards integrated aliases for Gastric Leiomyoma:

Name: Gastric Leiomyoma 12 14 69
Leiomyoma of the Stomach 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10087
NCIt 47 C3876
SNOMED-CT 64 276812001
UMLS 69 C0238440

Summaries for Gastric Leiomyoma

MalaCards based summary : Gastric Leiomyoma, also known as leiomyoma of the stomach, is related to leiomyoma and anca-associated vasculitis. An important gene associated with Gastric Leiomyoma is FH (Fumarate Hydratase), and among its related pathways/superpathways are Chks in Checkpoint Regulation and DNA Damage. Affiliated tissues include pituitary, thyroid and liver, and related phenotype is Increased viability with MLN4924 (a NAE inhibitor).

Related Diseases for Gastric Leiomyoma

Diseases related to Gastric Leiomyoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
id Related Disease Score Top Affiliating Genes
1 leiomyoma 10.5
2 anca-associated vasculitis 10.3 MGMT MSH6
3 pediatric ependymoma 10.3 CHGA KRT18
4 gliofibroma 10.2 CHGA MGMT
5 rectum squamous cell carcinoma 10.2 MGMT MLH1
6 large intestine adenocarcinoma 10.1 MLH1 MSH6
7 optic nerve sheath meningioma 10.1 MLH1 MSH6
8 dystonia, dopa-responsive, with or without hyperphenylalaninemia 10.1 CHGA GCG
9 benign fibrous mesothelioma 10.1 MLH1 MSH6
10 cataract 27, nuclear progressive 10.1 MLH1 MSH6
11 benign ependymoma 10.1 MLH1 MSH6
12 opitz-gbbb syndrome 10.0 CHGA FH
13 hereditary nephrotic syndromes, autosomal dominant 10.0 MLH1 MSH6
14 leydig cell tumor 10.0 CALD1 FH
15 optic papillitis 10.0 MLH1 MSH6
16 wolffian duct adenoma 10.0 MLH1 MSH6
17 muir-torre syndrome 10.0 MLH1 MSH6
18 mismatch repair cancer syndrome 10.0 MLH1 MSH6
19 nodular tenosynovitis 9.9 CALD1 KRT18
20 verrucous papilloma 9.9 MLH1 MSH6
21 cellular myxoid liposarcoma 9.9 MLH1 MSH6
22 congenital hypomyelination neuropathy 9.9 MGMT MLH1
23 male reproductive organ benign neoplasm 9.8 CHGA FH MLH1
24 lymphoplasmacytic lymphoma 9.8 MLH1 MSH6
25 adenoma 9.7
26 arrhythmogenic right ventricular cardiomyopathy 9.7 MGMT MLH1 MSH6
27 arteritic anterior ischemic optic neuropathy 9.7 MLH1 MSH6
28 wissler's syndrome 9.6 CHGA MLH1 MSH6
29 duodenitis 9.6
30 gastroduodenitis 9.6
31 amyloidosis 9.6
32 pancreatic adenoma 9.6
33 pituitary adenoma 9.6
34 multiple endocrine neoplasia 9.6
35 paraganglioma 9.6
36 esophagitis 9.6
37 leiomyosarcoma 9.6
38 pancreatitis 9.6
39 leiomyomatosis 9.6
40 multicentric papillary thyroid carcinoma 9.6
41 thyroiditis 9.6
42 mediastinitis 9.6
43 intussusception 9.6
44 benign shuddering attacks 9.6 CHGA GCG MLH1
45 trachea squamous cell carcinoma 9.5 MLH1 MSH6
46 apocrine adenoma 9.4 MGMT MLH1 MSH3 MSH6
47 sleeping sickness 6.5 CALD1 CHGA FH GCG KRT18 LIPG

Graphical network of the top 20 diseases related to Gastric Leiomyoma:



Diseases related to Gastric Leiomyoma

Symptoms & Phenotypes for Gastric Leiomyoma

GenomeRNAi Phenotypes related to Gastric Leiomyoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 8.92 MGMT MLH1 MSH3 MSH6

Drugs & Therapeutics for Gastric Leiomyoma

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Feasibility and Yield of a New 20 G ProCore Needle With Coiled Sheath in the Gastrointestinal Subepithelial Tumors Enrolling by invitation NCT02884154 Phase 4
2 Biopsy Protocol of Upper Gastrointestinal Subepithelial Tumors:Diagnostic Accuracy of EUS-FNB Versus Unroofing Biopsy Recruiting NCT02646241

Search NIH Clinical Center for Gastric Leiomyoma

Genetic Tests for Gastric Leiomyoma

Anatomical Context for Gastric Leiomyoma

MalaCards organs/tissues related to Gastric Leiomyoma:

39
Pituitary, Thyroid, Liver

Publications for Gastric Leiomyoma

Articles related to Gastric Leiomyoma:

(show top 50) (show all 78)
id Title Authors Year
1
Intragastric Single-Incision Laparoscopic Surgery for Gastric Leiomyoma: A Stepwise Approach. ( 28466402 )
2017
2
Endoscopic dissection of a symptomatic giant gastric leiomyoma arising from the muscularis propria. ( 28355652 )
2017
3
Laparoscopic Transgastric Enucleation of a Gastric Leiomyoma near the Esophagogastric Junction and Concomitant Sleeve Gastrectomy: Video Report. ( 26883931 )
2016
4
Partial gastrectomy for resection of a gastric leiomyoma in a guinea pig (Cavia porcellus). ( 27901456 )
2016
5
Gastric leiomyoma in a child with Gorlin-Goltz syndrome: First pediatric case. ( 26567923 )
2015
6
Epigenetic alterations in a gastric leiomyoma. ( 25544907 )
2014
7
Laparoscopic-Assisted Endoscopic Resection of a Gastric Leiomyoma. ( 25642406 )
2014
8
Intragastric endoscopic assisted single incision surgery for gastric leiomyoma of the esophagogastric junction. ( 24416603 )
2013
9
Gastric leiomyoma and hyperplastic polyposis coli in a patient with multiple cutaneous and uterine leiomyomatosis. ( 22713448 )
2012
10
Robotic-assisted laparoscopic wedge resection of a gastric leiomyoma with intraoperative ultrasound localization. ( 21919811 )
2011
11
Gastric leiomyoma in a free-living Atlantic bottlenosed dolphin (Tursiops truncatus). ( 17259457 )
2007
12
Laparoscopic wedge resection of gastric leiomyoma. ( 17212898 )
2006
13
Gastric leiomyoma. Is there an association with Helicobacter pylori? ( 15573227 )
2004
14
Symptomatic gastric leiomyoma mimicking giant gastric polyp: endoscopic diagnosis and removal. ( 15368793 )
2004
15
Laparoscopic wedge resection of gastric leiomyoma. ( 14974670 )
2004
16
Gastric leiomyoma presenting as gastric volvulus. ( 15030039 )
2003
17
Laparoscopic wedge resection of a gastric leiomyoma. ( 11443434 )
2001
18
Laparoscopic intragastric resection of gastric leiomyoma using needlescopic instruments. Case report. ( 11409411 )
2001
19
Gastroduodenal intussusception secondary to a gastric leiomyoma resulting in an ulceration. ( 10344450 )
1999
20
An undescribed coexistence of a subserosal exophytic gastric leiomyoma with a serous microcystic pancreatic adenoma. ( 10670168 )
1999
21
Surgical treatment of gastric leiomyoma in a dog. ( 10197242 )
1999
22
Laparoscopic intragastric resection of gastric leiomyoma close to the cardia using a flexible endocutter intraluminally. ( 10636561 )
1999
23
Combined laparoscopic treatment of gastric leiomyoma and gallstones. ( 9830549 )
1998
24
Posterior wall gastric leiomyoma: endoscopic tattooing facilitates laparoscopic resection. ( 9876718 )
1998
25
Laparoscopic management of a gastric perforation after snare removal of a gastric leiomyoma. ( 9689521 )
1998
26
Resection of a gastric leiomyoma using combined laparoscopic and gastroscopic approach. ( 9079612 )
1997
27
Cystic gastric leiomyoma--a diagnostic pitfall. ( 9396182 )
1997
28
Laparoscopic resection of posterior gastric leiomyoma. ( 9079609 )
1997
29
Laparoscopic intragastric surgery for gastric leiomyoma. ( 9079613 )
1997
30
Calcified gastric leiomyoma: a rare cause of calcification in the abdomen. ( 8583116 )
1995
31
Ossified gastric leiomyoma in a child: a case report. ( 7761163 )
1995
32
Combined laparoscopic and endoscopic approach to resection of gastric leiomyoma. ( 7612942 )
1995
33
Laparoscopic gastric resection for gastric leiomyoma. ( 7992156 )
1994
34
Large polypoid gastric leiomyoma with intermittent duodenal prolapse. ( 8253656 )
1993
35
Case report: simple liver cyst masquerading as a gastric leiomyoma--a diagnostic pitfall. ( 8243013 )
1993
36
Kinking of splenic artery mimicking gastric leiomyoma. ( 8262001 )
1993
37
Endoscopic closure of a perforation using metallic clips after snare excision of a gastric leiomyoma. ( 8495838 )
1993
38
Gastric leiomyoma: an unusual presentation. ( 1561201 )
1992
39
Injection therapy for bleeding gastric leiomyoma. ( 1473688 )
1992
40
Leiomyomatous tumors: presentation of a giant gastric leiomyoma and a review of the literature. ( 2668809 )
1989
41
Technetium-99m labeled RBC imaging in gastrointestinal bleeding from gastric leiomyoma. ( 3258215 )
1988
42
Enucleation of a gastric leiomyoma by a combined laser and snare electrocutting technique. ( 3366329 )
1988
43
Drug-induced bleeding of gastric leiomyoma. ( 3495170 )
1987
44
Gastric leiomyoma presenting with intraperitoneal haemorrhage. ( 3487681 )
1986
45
Gastric leiomyoma and its manifestations in Nigerians. A series of 10 patients. ( 3093727 )
1986
46
Gastric leiomyoma and its manifestations in Nigerians: a series of 10 patients. ( 3488812 )
1986
47
Complete healing of ulceration within a gastric leiomyoma. ( 3871713 )
1985
48
Esophageal/gastric leiomyoma in the laboratory Beagle. ( 6605959 )
1983
49
A simple and safe technique for the local excision of gastric leiomyoma using staples. ( 7137332 )
1982
50
Multiple endocrine neoplasia. Pituitary adenoma, multicentric papillary thyroid carcinoma, bilateral carotid body paraganglioma, parathyroid hyperplasia, gastric leiomyoma, and systemic amyloidosis. ( 7137085 )
1982

Variations for Gastric Leiomyoma

Expression for Gastric Leiomyoma

Search GEO for disease gene expression data for Gastric Leiomyoma.

Pathways for Gastric Leiomyoma

GO Terms for Gastric Leiomyoma

Biological processes related to Gastric Leiomyoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.76 MGMT MLH1 MSH3 MSH6
2 DNA repair GO:0006281 9.67 MGMT MLH1 MSH3 MSH6
3 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.48 MLH1 MSH6
4 somatic hypermutation of immunoglobulin genes GO:0016446 9.43 MLH1 MSH6
5 isotype switching GO:0045190 9.4 MLH1 MSH6
6 negative regulation of DNA recombination GO:0045910 9.32 MSH3 MSH6
7 positive regulation of helicase activity GO:0051096 9.26 MSH3 MSH6
8 maintenance of DNA repeat elements GO:0043570 9.16 MSH3 MSH6
9 mismatch repair GO:0006298 9.13 MLH1 MSH3 MSH6
10 somatic recombination of immunoglobulin gene segments GO:0016447 8.62 MLH1 MSH6

Molecular functions related to Gastric Leiomyoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 oxidized purine DNA binding GO:0032357 9.26 MSH3 MSH6
2 single guanine insertion binding GO:0032142 9.16 MSH3 MSH6
3 mismatched DNA binding GO:0030983 9.13 MLH1 MSH3 MSH6
4 damaged DNA binding GO:0003684 9.02 MSH6
5 guanine/thymine mispair binding GO:0032137 8.8 MLH1 MSH3 MSH6

Sources for Gastric Leiomyoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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