MCID: GST064
MIFTS: 39

Gastric Outlet Obstruction malady

Gastrointestinal diseases category

Summaries for Gastric Outlet Obstruction

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Sources:
66Wikipedia, 34MalaCards
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Wikipedia:66 Gastric outlet obstruction (often abbreviated as GOO) is a medical condition where there is an... more...

MalaCards: Gastric Outlet Obstruction is related to duodenitis and peptic ulcer disease. An important gene associated with Gastric Outlet Obstruction is ATP4A (ATPase, H+/K+ exchanging, alpha polypeptide), and among its related pathways are Salivary secretion and Gastrin-CREB signalling pathway via PKC and MAPK. The compounds esomeprazole and rabeprazole have been mentioned in the context of this disorder. Affiliated tissues include small intestine, pancreas and liver, and related mouse phenotype digestive/alimentary.

Aliases & Classifications for Gastric Outlet Obstruction

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11DISEASES, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

gastric outlet obstruction 11 63


Related Diseases for Gastric Outlet Obstruction

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Gastric Outlet Obstruction:



Diseases related to gastric outlet obstruction

Symptoms for Gastric Outlet Obstruction

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Drugs & Therapeutics for Gastric Outlet Obstruction

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Gastric Outlet Obstruction

Drug clinical trials:

Search ClinicalTrials for Gastric Outlet Obstruction

Search NIH Clinical Center for Gastric Outlet Obstruction

Search CenterWatch for Gastric Outlet Obstruction

Genetic Tests for Gastric Outlet Obstruction

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Anatomical Context for Gastric Outlet Obstruction

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Sources:
34MalaCards
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MalaCards organs/tissues related to Gastric Outlet Obstruction:

34
Small intestine, Pancreas, Liver, Spleen, Testes, Breast, Myeloid, Colon, Kidney, Skin

Animal Models for Gastric Outlet Obstruction or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Gastric Outlet Obstruction:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.6GAST, ATP12A, ATP4A

Publications for Gastric Outlet Obstruction

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Sources:
53PubMed
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Articles related to Gastric Outlet Obstruction:

(show top 50)    (show all 487)
idTitleAuthorsYear
1
Gastric heterotopic pancreas abscess leading to gastric outlet obstruction. (23948200)
2013
2
Long-term outcome of palliative therapy for gastric outlet obstruction caused by unresectable gastric cancer in patients with good performance status: endoscopic stenting versus surgery. (23522025)
2013
3
Duplication cyst of pyloric canal: a rare cause of pediatric gastric outlet obstruction: rare case report. (24426605)
2013
4
First Reported Case of Intentional Use of a Duodenal Stent to Treat Gastric Outlet Obstruction Prior to Pancreaticoduodenectomy in a Patient with Pancreatic Cancer. (24114048)
2013
5
Large-Diameter (30-35 mm) Pneumatic Balloon Dilatation of The Pylorus In Patients With Gastric Outlet Obstruction Symptoms After Esophagectomy. (23820681)
2013
6
Bouveret's syndrome: successful endoscopic treatment of gastric outlet obstruction caused by an impacted gallstone. (22414360)
2012
7
Clinical outcomes of secondary stent-in-stent self-expanding metal stent placement for primary stent malfunction in malignant gastric outlet obstruction. (22835857)
2012
8
Surgical management of benign gastric outlet obstruction in the elderly. (22683983)
2012
9
Endoscopic balloon dilatation without fluoroscopy for treating gastric outlet obstruction because of benign etiologies. (21052720)
2011
10
Endoscopic management of multiple large antral hyperplastic polyps causing gastric outlet obstruction. (21834480)
2011
11
Safety and efficacy of a new non-foreshortening nitinol stent in malignant gastric outlet obstruction (DUONITI study): a prospective, multicenter study. (21656455)
2011
12
Development of a duodenal gallstone ileus with gastric outlet obstruction (Bouveret syndrome) four months after successful treatment of symptomatic gallstone disease with cholecystitis and cholangitis: a case report. (21092262)
2010
13
A systematic review of methods to palliate malignant gastric outlet obstruction. (19551436)
2010
14
Endoscopic balloon dilation in caustic-induced chronic gastric outlet obstruction. (19136104)
2009
15
Bezoar in gastro-jejunostomy presenting with symptoms of gastric outlet obstruction: a case report and review of the literature. (18831730)
2008
16
Gastric carcinoid presented as gastric outlet obstruction. (20085045)
2008
17
Post-esophagectomy gastric outlet obstruction: role of pyloromyotomy and management with endoscopic pyloric dilatation. (17166733)
2007
18
Bouveret's syndrome: management and strategy of a rare cause of gastric outlet obstruction. (17429202)
2007
19
Morbidity-associated factors after gastrojejunostomy for malignant gastric outlet obstruction. (17939415)
2007
20
Clinical challenges and images in GI. Gallstone impacted in duodenum causing gastric outlet obstruction (Bouveret syndrome). (17919482)
2007
21
Gastric outlet obstruction. (18067699)
2007
22
Gastrointestinal neurofibromatosis: an unusual cause of gastric outlet obstruction. (16022006)
2005
23
Ectopic pancreas as a cause of gastric outlet obstruction in an infant. (15627663)
2004
24
Vagotomy and gastrojejunostomy for benign gastric outlet obstruction. (15630940)
2004
25
Gastric outlet obstruction secondary to linitis plastica of the stomach as shown on transabdominal sonography. (15292571)
2004
26
Corrosive-induced gastric outlet obstruction. (14703606)
2003
27
Multiple giant duodenal gallstones causing gastric outlet obstruction: Bouveret's minefield revisited. (14696446)
2003
28
An unusual cause of gastric outlet obstruction: a case report. (14603827)
2003
29
Gastric outlet obstruction caused by a heterotopic pancreas in a pregnant woman: report of a case. (14669092)
2003
30
Gastric outlet obstruction by an antral mucosal diaphragm: a case of a congenital anomaly revealed by an acquired disease. (14618524)
2003
31
A rare cause of gastric outlet obstruction in the newborn: Pyloric ectopic pancreas. (11782002)
2002
32
Gastric outlet obstruction following surgery for morbid obesity: efficacy of fluoroscopically guided balloon dilation. (11756707)
2002
33
Laparoscopic gatrojejunostomy for palliation of gastric outlet obstruction in unresectable gastric cancer. (12073005)
2002
34
Clinical experience in the treatment of ulcer-induced gastric outlet obstruction in seven children. (11021004)
2000
35
Gastric outlet obstruction due to benign dilatation of gallbladder. (11147955)
2000
36
Gastric outlet obstruction as a late complication of formaldehyde ingestion: a case report. (10445565)
1999
37
Granulomatous gastritis presenting as gastric outlet obstruction: a case report. (9789139)
1998
38
Palliation of malignant gastric outlet obstruction using an endoscopically placed Wallstent. (9540881)
1998
39
Gastric lactobezoar: a rare cause of gastric outlet obstruction. (9291515)
1997
40
Re: W. de Boer: Gastric outlet obstruction and Helicobacter pylori. (9317100)
1997
41
Endotherapy for gastric outlet obstruction. (8635720)
1996
42
Resolution of gastric outlet obstruction after eradication of Helicobacter pylori. (8583113)
1995
43
Leiomyoblastoma causing acute gastric outlet obstruction in an infant. (7807332)
1994
44
Prospective randomized study comparing three surgical techniques for the treatment of gastric outlet obstruction secondary to duodenal ulcer. (8101050)
1993
45
Endoscopic management of gastric outlet obstruction. (1906031)
1991
46
Management of gastric outlet obstruction caused by ovarian cancer. (2013454)
1991
47
Marked hypergastrinemia in gastric outlet obstruction. (2760432)
1989
48
Carcinoid tumour presenting as recurrent gastric outlet obstruction: a case of long-term survival. (3602991)
1987
49
Preliminary experience with hydrostatic balloon dilation of gastric outlet obstruction. (3710101)
1986
50
Gastric outlet obstruction secondary to a gallstone (Bouveret's syndrome) (4020089)
1985

Variations for Gastric Outlet Obstruction

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Expression for genes affiliated with Gastric Outlet Obstruction

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gastric Outlet Obstruction

Search GEO for disease gene expression data for Gastric Outlet Obstruction.

Pathways for genes affiliated with Gastric Outlet Obstruction

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Sources:
51PathCards, 31KEGG, 56Reactome, 39NCBI BioSystems Database
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Pathways related to Gastric Outlet Obstruction according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4GAST, ATP4A
2
Show member pathways
9.3GAST, MLN
3
Show member pathways
9.1ATP12A, ATP4A
4
Show member pathways
calcium transport I39
9.1ATP12A, ATP4A

Compounds for genes affiliated with Gastric Outlet Obstruction

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 25HMDB, 30IUPHAR, 62Tocris Bioscience, 3BitterDB
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Compounds related to Gastric Outlet Obstruction according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1esomeprazole46 52 1211.8GAST, ATP4A
2rabeprazole46 52 25 1212.8GAST, ATP4A
3lansoprazole46 52 25 1212.8GAST, ATP4A
4trimebutine469.7MLN, GAST
5lafutidine469.7GAST, MLN
6bethanechol46 30 1211.7MLN, GAST
7domperidone46 30 1211.7GAST, MLN
8oxyntomodulin46 6210.6MLN, GAST
9ondansetron52 46 25 1212.6GAST, MLN
10ranitidine46 30 25 1212.6GAST, MLN
11famotidine46 3 25 1212.6GAST, MLN
12erythromycin46 3 52 1212.6GAST, MLN
13octreotide46 62 30 1212.6GAST, MLN
14atropine46 30 1211.6MLN, GAST
15acetaminophen46 3 52 25 1213.5GAST, MLN
16nifedipine46 30 52 1212.5GAST, MLN
175-hydroxytryptamine469.5MLN, GAST
18thyroxine46 2510.4GAST, MLN
19acth469.4GAST, MLN
20histamine46 30 2511.3MLN, GAST
21acetylcholine46 52 30 25 1213.2GAST, MLN
22omeprazole46 52 30 25 1213.2GAST, ATP4A, MLN
23potassium46 25 1211.1ATP12A, ATP4A
24pantoprazole46 52 25 1212.0GAST, ATP12A, ATP4A
25Phosphate258.8ATP12A, ATP4A
26hydrogen46 259.8MLN, ATP12A, GAST

GO Terms for genes affiliated with Gastric Outlet Obstruction

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Sources:
17Gene Ontology
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Biological processes related to Gastric Outlet Obstruction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1G-protein coupled receptor signaling pathwayGO:0071869.3GAST, MLN
2ATP biosynthetic processGO:0067549.0ATP12A, ATP4A
3ion transmembrane transportGO:0342208.8ATP12A, ATP4A

Molecular functions related to Gastric Outlet Obstruction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.3GAST, MLN
2hydrogen:potassium-exchanging ATPase activityGO:0089008.8ATP12A, ATP4A

Products for genes affiliated with Gastric Outlet Obstruction

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gastric Outlet Obstruction

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet