MCID: GST064
MIFTS: 24

Gastric Outlet Obstruction malady

Gastrointestinal diseases category

Summaries for Gastric Outlet Obstruction

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63Wikipedia, 32MalaCards
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Wikipedia:63 Gastric outlet obstruction (often abbreviated as GOO) is a medical condition where there is an... more...

MalaCards: Gastric Outlet Obstruction is related to duodenitis and gastroduodenitis. An important gene associated with Gastric Outlet Obstruction is SPAG7 (sperm associated antigen 7), and among its related pathways are Gastric acid secretion and Ion channel transport. The compounds esomeprazole and rabeprazole have been mentioned in the context of this disorder. Affiliated tissues include small intestine.

Aliases & Classifications for Gastric Outlet Obstruction

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10DISEASES, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

gastric outlet obstruction 10 60


Related Diseases for Gastric Outlet Obstruction

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Gastric Outlet Obstruction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 101)
idRelated DiseaseScoreTop Affiliating Genes
1duodenitis31.4GAST, ATP12A, ATP4A
2gastroduodenitis30.8GAST
3peptic ulcer30.7ATP4A, ATP12A, GAST
4stomach cancer30.6ATP4A, GAST, ATP12A
5gastritis30.6MLN, GAST, ATP4A, ATP12A
6pyloric stenosis30.6GAST
7esophagitis30.5ATP4A, ATP12A, GAST
8gastrinoma30.2ATP4A, ATP12A, GAST
9gastroparesis30.2GAST, SPAG7, MLN
10duodenal obstruction11.0
11gastric dilatation10.9
12pancreatitis10.8
13gastric ulcer10.8
14tuberculosis10.6
15duodenal ulcer10.6
16intussusception10.5
17morbid obesity10.5
18adenocarcinoma10.5
19gastric adenocarcinoma10.5
20obesity10.5
21pancreatic cancer10.5
22peritonitis10.5
23acute pancreatitis10.4
24chronic granulomatous disease10.4
25gastric lymphoma10.4
26duodenal disease10.4
27epidermolysis bullosa10.4
28neurofibromatosis10.3
29obstructive jaundice10.3
30eosinophilic gastritis10.3
31peutz-jeghers syndrome10.3
32hypertrophic pyloric stenosis10.3
33amyloidosis10.3
34bladder carcinoma10.3
35gastroenteritis10.3
36lipoma10.3
37crohn's disease10.2
38strongyloidiasis10.2
39papillary serous adenocarcinoma10.2
40ankylosing spondylitis10.2
41gastric hemangioma10.2
42junctional epidermolysis bullosa10.2
43ataxia telangiectasia10.2
44systemic lupus erythematosus10.2
45superior mesenteric artery syndrome10.2
46giant hemangioma10.2
47meckel's diverticulum10.2
48peritoneal serous papillary adenocarcinoma10.2
49duodenal gastrinoma10.2
50gastric antral vascular ectasia10.2

Graphical network of the top 20 diseases related to Gastric Outlet Obstruction:



Diseases related to gastric outlet obstruction

Clinical Features for Gastric Outlet Obstruction

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Drugs & Therapeutics for Gastric Outlet Obstruction

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Gastric Outlet Obstruction

Drug clinical trials:

Search ClinicalTrials for Gastric Outlet Obstruction

Search NIH Clinical Center for Gastric Outlet Obstruction

Search CenterWatch for Gastric Outlet Obstruction

Genetic Tests for Gastric Outlet Obstruction

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Anatomical Context for Gastric Outlet Obstruction

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Sources:
32MalaCards
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MalaCards organs/tissues related to Gastric Outlet Obstruction:

32
Small intestine

Animal Models for Gastric Outlet Obstruction or affiliated genes

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Publications for Gastric Outlet Obstruction

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Genetic Variations for Gastric Outlet Obstruction

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Expression for genes affiliated with Gastric Outlet Obstruction

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gastric Outlet Obstruction

Search GEO for disease gene expression data for Gastric Outlet Obstruction.

Pathways for genes affiliated with Gastric Outlet Obstruction

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Sources:
29KEGG, 53Reactome
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Pathways related to Gastric Outlet Obstruction according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5ATP4A, GAST
2
Hide members
9.4ATP4A, ATP12A

Compounds for genes affiliated with Gastric Outlet Obstruction

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Gastric Outlet Obstruction according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1esomeprazole44 49 1111.8ATP4A, GAST
2rabeprazole44 49 11 2412.8ATP4A, GAST
3lansoprazole49 44 11 2412.8ATP4A, GAST
4trimebutine449.5GAST, MLN
5lafutidine449.4MLN, GAST
6bethanechol44 28 1111.4GAST, MLN
7domperidone44 28 1111.4MLN, GAST
8oxyntomodulin44 5910.4MLN, GAST
9ondansetron44 49 11 2412.4GAST, MLN
10ranitidine44 28 11 2412.4GAST, MLN
11famotidine44 2 11 2412.3GAST, MLN
12erythromycin44 49 2 1112.3MLN, GAST
13octreotide44 59 28 1112.2GAST, MLN
14pantoprazole44 49 11 2412.2GAST, ATP4A, ATP12A
15atropine44 28 1111.2MLN, GAST
16acetaminophen44 2 49 11 2413.1GAST, MLN
17thyroxine44 2410.1GAST, MLN
18nifedipine44 49 28 1112.0GAST, MLN
19omeprazole44 28 49 11 2413.0GAST, ATP4A, MLN
205-hydroxytryptamine448.8MLN, GAST
21hydrogen44 249.7MLN, GAST, ATP12A

GO Terms for genes affiliated with Gastric Outlet Obstruction

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Sources:
16Gene Ontology
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Biological processes related to Gastric Outlet Obstruction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ion transmembrane transportGO:0342209.4ATP4A, ATP12A
2ATP biosynthetic processGO:0067549.1ATP4A, ATP12A

Molecular functions related to Gastric Outlet Obstruction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.1MLN, GAST
2hydrogen:potassium-exchanging ATPase activityGO:0089009.1ATP4A, ATP12A

Products for genes affiliated with Gastric Outlet Obstruction

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gastric Outlet Obstruction

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet