MCID: GST016
MIFTS: 33

Gastric Signet Ring Cell Adenocarcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Gastric Signet Ring Cell Adenocarcinoma

MalaCards integrated aliases for Gastric Signet Ring Cell Adenocarcinoma:

Name: Gastric Signet Ring Cell Adenocarcinoma 12 14
Signet Ring Cell Adenocarcinoma of the Stomach 12
Signet Ring Cell Gastric Adenocarcinoma 69

Classifications:



External Ids:

Disease Ontology 12 DOID:8025
NCIt 47 C5250
UMLS 69 C1335965

Summaries for Gastric Signet Ring Cell Adenocarcinoma

MalaCards based summary : Gastric Signet Ring Cell Adenocarcinoma, also known as signet ring cell adenocarcinoma of the stomach, is related to gastric adenocarcinoma and mesenchymoma, and has symptoms including abdominal pain and dyspepsia. An important gene associated with Gastric Signet Ring Cell Adenocarcinoma is UPK2 (Uroplakin 2), and among its related pathways/superpathways is Preimplantation Embryo. The drugs Oxaliplatin and Pancrelipase have been mentioned in the context of this disorder. Affiliated tissues include bone and bone marrow, and related phenotypes are cellular and cardiovascular system

Related Diseases for Gastric Signet Ring Cell Adenocarcinoma

Diseases related to Gastric Signet Ring Cell Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 154)
id Related Disease Score Top Affiliating Genes
1 gastric adenocarcinoma 10.6 CDX2 GATA3
2 mesenchymoma 10.5 CDX2 PGR
3 intrahepatic cholangiocarcinoma 10.5 CDX2 CEACAM5
4 giant cell tumor 10.5 CDX2 CEACAM5
5 ovarian melanoma 10.5 CDX2 SMUG1
6 proliferative type fibrocystic change of breast 10.5 CDX2 CEACAM5
7 pancreatic signet ring cell adenocarcinoma 10.5 CDH1 CDX2
8 intracranial sinus thrombosis 10.4 CDX2 CEACAM5
9 uterine corpus adenofibroma 10.4 CDX2 CEACAM5
10 adenocarcinoma 10.4
11 signet ring cell adenocarcinoma 10.4
12 wissler's syndrome 10.4 CDX2 SMUG1
13 benign meningioma 10.4 CEACAM5 PGR
14 bile duct mucoepidermoid carcinoma 10.4 CEACAM5 PGR
15 childhood ovarian endodermal sinus tumor 10.4 CDX2 CEACAM5
16 skin sarcoma 10.4 CEACAM5 PGR
17 collagen disease 10.4 CDH1 SMUG1
18 kidney leiomyosarcoma 10.4 PGR SMUG1
19 diffuse lipomatosis 10.4 CEACAM5 PGR
20 secondary syphilis 10.4 CDH1 CEACAM5
21 kallmann syndrome 10.4 CEACAM5 PGR
22 cystic basal cell carcinoma 10.4 CDH1 CEACAM5
23 partial of retinal vein occlusion 10.4 CEACAM5 GATA3
24 intestine carcinoma in situ 10.3 CEACAM5 SMUG1
25 ureter squamous cell carcinoma 10.3 CEACAM5 SMUG1
26 monieziasis 10.3 CEACAM5 SMUG1
27 lipid-cell variant infiltrating bladder urothelial carcinoma 10.3 CEACAM5 SMUG1
28 childhood teratoma of the ovary 10.3 CDH1 CDX2 UPK2
29 breast mucinous carcinoma 10.3 CDX2 SMUG1
30 familial periodic paralysis 10.3 CEACAM5 SMUG1
31 microcystic meningioma 10.3 CDX2 CEACAM5
32 ocular motility disease 10.3 CEACAM5 SMUG1
33 bartholin's gland benign neoplasm 10.3 ESR1 PGR
34 central nervous system organ benign neoplasm 10.3 ESR1 PGR
35 gallbladder leiomyoma 10.3 ESR1 PGR
36 lung adenoma 10.3 ESR1 PGR
37 trachea sarcoma 10.3 CEACAM5 PGR
38 glaucoma, hereditary 10.3 ESR1 PGR
39 fallopian tube benign neoplasm 10.3 ESR1 PGR
40 paranasal sinus disease 10.3 ESR1 PGR
41 dartoic leiomyoma 10.3 ESR1 PGR
42 urinary bladder inverted papilloma 10.3 ESR1 PGR
43 spinal cancer 10.3 ESR1 PGR
44 subglottis verrucous carcinoma 10.3 ESR1 PGR
45 deafness, autosomal dominant 8/12 10.3 ESR1 PGR
46 brain stem glioma 10.3 CEACAM5 SMUG1
47 intestinal perforation 10.3 ESR1 PGR
48 her2-receptor positive breast cancer 10.3 ESR1 PGR
49 gerstmann syndrome 10.3 CEACAM5 SMUG1
50 breast sarcoma 10.3 CDH1 ESR1

Graphical network of the top 20 diseases related to Gastric Signet Ring Cell Adenocarcinoma:



Diseases related to Gastric Signet Ring Cell Adenocarcinoma

Symptoms & Phenotypes for Gastric Signet Ring Cell Adenocarcinoma

UMLS symptoms related to Gastric Signet Ring Cell Adenocarcinoma:


abdominal pain, dyspepsia

MGI Mouse Phenotypes related to Gastric Signet Ring Cell Adenocarcinoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.87 GATA3 PGR PIP SMUG1 CDH1 CDX2
2 cardiovascular system MP:0005385 9.85 CDH1 CDX2 ESR1 GATA3 PGR PIP
3 digestive/alimentary MP:0005381 9.65 CDH1 CDX2 ESR1 GATA3 PIP
4 endocrine/exocrine gland MP:0005379 9.63 CDH1 CDX2 ESR1 GATA3 PGR PIP
5 neoplasm MP:0002006 9.35 CDH1 CDX2 ESR1 PGR SMUG1
6 reproductive system MP:0005389 9.1 CDH1 CDX2 ESR1 GATA3 PGR PIP

Drugs & Therapeutics for Gastric Signet Ring Cell Adenocarcinoma

Drugs for Gastric Signet Ring Cell Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 5310940 9887054 43805 6857599
2
Pancrelipase Approved Phase 3 53608-75-6
3 pancreatin Phase 3
4 Pharmaceutical Solutions Phase 3
5
Cisplatin Approved 15663-27-1 84093 441203 2767
6
Epirubicin Approved 56420-45-2 41867
7
Fluorouracil Approved 51-21-8 3385

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 D2 Resection and HIPEC (Hyperthermic Intraperitoneal Chemoperfusion) in Locally Advanced Gastric Carcinoma Recruiting NCT01882933 Phase 3 HIPEC (Hyperthermic Intraperitoneal Chemoperfusion) with oxaliplatin
2 Prognosis of Signet Ring Cells in Upper Digestive Neoplasms Completed NCT01249859
3 NBI for Identifying Resection Margin Status in Gastric Cancer Completed NCT02926716
4 Evaluation of Surgery Versus Primary Chemotherapy in Resectable Signet Ring Cell Gastric Adenocarcinoma Recruiting NCT01717924

Search NIH Clinical Center for Gastric Signet Ring Cell Adenocarcinoma

Genetic Tests for Gastric Signet Ring Cell Adenocarcinoma

Anatomical Context for Gastric Signet Ring Cell Adenocarcinoma

MalaCards organs/tissues related to Gastric Signet Ring Cell Adenocarcinoma:

39
Bone, Bone Marrow

Publications for Gastric Signet Ring Cell Adenocarcinoma

Articles related to Gastric Signet Ring Cell Adenocarcinoma:

id Title Authors Year
1
Bone marrow infiltration as the initial presentation of gastric signet ring cell adenocarcinoma. ( 25436133 )
2014
2
Biopsy-triggered gastric signet ring cell adenocarcinoma proliferation. ( 25524189 )
2014
3
Risk factors of peritoneal recurrence in eso-gastric signet ring cell adenocarcinoma: results of a multicentre retrospective study. ( 23313257 )
2013
4
The impact of perioperative chemotherapy on survival in patients with gastric signet ring cell adenocarcinoma: a multicenter comparative study. ( 22005144 )
2011
5
Unfound gastric signet ring-cell adenocarcinoma after gastric biopsy. ( 20425670 )
2010
6
Sister Mary Joseph's nodule as the sole presenting sign of gastric signet ring cell adenocarcinoma. ( 20739130 )
2010
7
Gastric signet-ring cell adenocarcinoma presenting with left arm deep-vein thrombosis and bilateral chylothorax. ( 18263634 )
2008
8
Gastric signet-ring cell adenocarcinoma metastatic to the gingiva: a case report. ( 16831674 )
2006
9
Epididymal metastasis from gastric signet ring cell adenocarcinoma. ( 12010596 )
2002
10
Gastric signet ring cell adenocarcinoma metastatic to the iris. ( 11239875 )
2001

Variations for Gastric Signet Ring Cell Adenocarcinoma

Expression for Gastric Signet Ring Cell Adenocarcinoma

Search GEO for disease gene expression data for Gastric Signet Ring Cell Adenocarcinoma.

Pathways for Gastric Signet Ring Cell Adenocarcinoma

Pathways related to Gastric Signet Ring Cell Adenocarcinoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.58 CDH1 CDX2 GATA3

GO Terms for Gastric Signet Ring Cell Adenocarcinoma

Biological processes related to Gastric Signet Ring Cell Adenocarcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.33 ESR1 GATA3 PGR
2 positive regulation of cell differentiation GO:0045597 9.26 CDX2 GATA3
3 positive regulation of transcription, DNA-templated GO:0045893 9.26 CDH1 CDX2 ESR1 GATA3
4 uterus development GO:0060065 8.62 ESR1 GATA3

Molecular functions related to Gastric Signet Ring Cell Adenocarcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077 9.43 ESR1 GATA3 PGR
2 core promoter sequence-specific DNA binding GO:0001046 9.32 ESR1 GATA3
3 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0004879 9.16 ESR1 PGR
4 steroid binding GO:0005496 8.96 ESR1 PGR
5 sequence-specific DNA binding GO:0043565 8.92 CDX2 ESR1 GATA3 PGR

Sources for Gastric Signet Ring Cell Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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