MCID: GST016
MIFTS: 35

Gastric Signet Ring Cell Adenocarcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Gastric Signet Ring Cell Adenocarcinoma

MalaCards integrated aliases for Gastric Signet Ring Cell Adenocarcinoma:

Name: Gastric Signet Ring Cell Adenocarcinoma 12 14
Signet Ring Cell Adenocarcinoma of the Stomach 12
Signet Ring Cell Gastric Adenocarcinoma 69

Classifications:



External Ids:

Disease Ontology 12 DOID:8025
NCIt 46 C5250
UMLS 69 C1335965

Summaries for Gastric Signet Ring Cell Adenocarcinoma

MalaCards based summary : Gastric Signet Ring Cell Adenocarcinoma, also known as signet ring cell adenocarcinoma of the stomach, is related to signet ring cell adenocarcinoma and adenocarcinoma, and has symptoms including dyspepsia and abdominal pain. An important gene associated with Gastric Signet Ring Cell Adenocarcinoma is UPK2 (Uroplakin 2), and among its related pathways/superpathways are Gastric cancer and Preimplantation Embryo. The drugs Cisplatin and Epirubicin have been mentioned in the context of this disorder. Affiliated tissues include bone and bone marrow, and related phenotypes are cellular and cardiovascular system

Related Diseases for Gastric Signet Ring Cell Adenocarcinoma

Diseases related to Gastric Signet Ring Cell Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 153)
# Related Disease Score Top Affiliating Genes
1 signet ring cell adenocarcinoma 31.2 CDH1 CDX2
2 adenocarcinoma 10.5
3 thymus adenocarcinoma 10.3 CDX2 CEACAM5
4 rectum adenocarcinoma 10.3 CDX2 CEACAM5
5 mucinous ovarian cystadenoma 10.3 CDX2 CEACAM5
6 esophageal adenosquamous carcinoma 10.3 CDH1 CEACAM5
7 biliary papillomatosis 10.3 CDX2 CEACAM5
8 superior mesenteric artery syndrome 10.3 CDX2 CEACAM5
9 vulvar syringoma 10.3 ESR1 PGR
10 granulomatous endometritis 10.3 CEACAM5 PGR
11 vestibular gland benign neoplasm 10.3 ESR1 PGR
12 ovarian mucinous neoplasm 10.3 CDX2 CEACAM5
13 lung leiomyoma 10.3 ESR1 PGR
14 breast mucoepidermoid carcinoma 10.3 CEACAM5 PGR
15 bartholin's gland adenoma 10.3 ESR1 PGR
16 glassy cell carcinoma of the cervix 10.3 ESR1 PGR
17 vulvar benign neoplasm 10.2 ESR1 PGR
18 trigonitis 10.2 ESR1 PGR
19 vulvar leiomyoma 10.2 ESR1 PGR
20 predominantly cortical thymoma 10.2 ESR1 PGR
21 intracystic papillary adenoma 10.2 CEACAM5 PGR
22 breast medullary carcinoma 10.2 ESR1 PGR
23 breast scirrhous carcinoma 10.2 ESR1 PGR
24 progesterone resistance 10.2 ESR1 PGR
25 progesterone-receptor positive breast cancer 10.2 ESR1 PGR
26 cribriform carcinoma 10.2 ESR1 PGR
27 bartholin's gland benign neoplasm 10.2 ESR1 PGR
28 endometrial squamous cell carcinoma 10.2 ESR1 PGR
29 endometrial mucinous adenocarcinoma 10.2 ESR1 PGR
30 deep angioma 10.2 ESR1 PGR
31 pancreatic serous cystadenoma 10.2 CEACAM5 PGR
32 apocrine adenocarcinoma 10.2 ESR1 PGR
33 chondroid chordoma 10.2 CDH1 CEACAM5
34 gender identity disorder 10.2 ESR1 PGR
35 jejunal adenocarcinoma 10.2 CDX2 SMUG1
36 cervical carcinosarcoma 10.2 ESR1 PGR
37 clear cell acanthoma 10.2 CEACAM5 GATA3
38 synchronous bilateral breast carcinoma 10.2 ESR1 PGR
39 lobular neoplasia 10.2 CDH1 ESR1
40 breast adenoid cystic carcinoma 10.2 ESR1 PGR
41 intramuscular hemangioma 10.2 ESR1 PGR
42 cystitis cystica 10.2 CDX2 GATA3 UPK2
43 estrogen excess 10.2 ESR1 PGR
44 infiltrative basal cell carcinoma 10.2 CDH1 CEACAM5
45 glycogen-rich clear cell breast carcinoma 10.2 ESR1 PGR
46 mammographic density 10.2 ESR1 PGR
47 retinitis pigmentosa 47 10.2 ESR1 PGR
48 adenomyosis 10.2 ESR1 PGR
49 retinitis pigmentosa 20 10.2 ESR1 PGR
50 gastric diffuse adenocarcinoma 10.2 CDH1 CDX2 UPK2

Graphical network of the top 20 diseases related to Gastric Signet Ring Cell Adenocarcinoma:



Diseases related to Gastric Signet Ring Cell Adenocarcinoma

Symptoms & Phenotypes for Gastric Signet Ring Cell Adenocarcinoma

UMLS symptoms related to Gastric Signet Ring Cell Adenocarcinoma:


dyspepsia, abdominal pain

MGI Mouse Phenotypes related to Gastric Signet Ring Cell Adenocarcinoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.87 ESR1 GATA3 PGR PIP CDH1 SMUG1
2 cardiovascular system MP:0005385 9.85 ESR1 GATA3 PGR PIP CDH1 CDX2
3 digestive/alimentary MP:0005381 9.65 ESR1 GATA3 PIP CDH1 CDX2
4 endocrine/exocrine gland MP:0005379 9.63 GATA3 PGR PIP CDH1 CDX2 ESR1
5 neoplasm MP:0002006 9.35 PGR CDH1 SMUG1 CDX2 ESR1
6 reproductive system MP:0005389 9.1 GATA3 PGR PIP CDH1 CDX2 ESR1

Drugs & Therapeutics for Gastric Signet Ring Cell Adenocarcinoma

Drugs for Gastric Signet Ring Cell Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved 15663-27-1 2767 441203 84093
2
Epirubicin Approved 56420-45-2 41867
3
Fluorouracil Approved 51-21-8 3385

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of Surgery Versus Primary Chemotherapy in Resectable Signet Ring Cell Gastric Adenocarcinoma Recruiting NCT01717924

Search NIH Clinical Center for Gastric Signet Ring Cell Adenocarcinoma

Genetic Tests for Gastric Signet Ring Cell Adenocarcinoma

Anatomical Context for Gastric Signet Ring Cell Adenocarcinoma

MalaCards organs/tissues related to Gastric Signet Ring Cell Adenocarcinoma:

38
Bone, Bone Marrow

Publications for Gastric Signet Ring Cell Adenocarcinoma

Articles related to Gastric Signet Ring Cell Adenocarcinoma:

# Title Authors Year
1
Bone marrow infiltration as the initial presentation of gastric signet ring cell adenocarcinoma. ( 25436133 )
2014
2
Biopsy-triggered gastric signet ring cell adenocarcinoma proliferation. ( 25524189 )
2014
3
Risk factors of peritoneal recurrence in eso-gastric signet ring cell adenocarcinoma: results of a multicentre retrospective study. ( 23313257 )
2013
4
The impact of perioperative chemotherapy on survival in patients with gastric signet ring cell adenocarcinoma: a multicenter comparative study. ( 22005144 )
2011
5
Sister Mary Joseph's nodule as the sole presenting sign of gastric signet ring cell adenocarcinoma. ( 20739130 )
2010
6
Unfound gastric signet ring-cell adenocarcinoma after gastric biopsy. ( 20425670 )
2010
7
Gastric signet-ring cell adenocarcinoma presenting with left arm deep-vein thrombosis and bilateral chylothorax. ( 18263634 )
2008
8
Gastric signet-ring cell adenocarcinoma metastatic to the gingiva: a case report. ( 16831674 )
2006
9
Epididymal metastasis from gastric signet ring cell adenocarcinoma. ( 12010596 )
2002
10
Gastric signet ring cell adenocarcinoma metastatic to the iris. ( 11239875 )
2001

Variations for Gastric Signet Ring Cell Adenocarcinoma

Expression for Gastric Signet Ring Cell Adenocarcinoma

Search GEO for disease gene expression data for Gastric Signet Ring Cell Adenocarcinoma.

Pathways for Gastric Signet Ring Cell Adenocarcinoma

Pathways related to Gastric Signet Ring Cell Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.92 CDH1 CDX2 ESR1 PGR
2 10.58 CDH1 CDX2 GATA3

GO Terms for Gastric Signet Ring Cell Adenocarcinoma

Biological processes related to Gastric Signet Ring Cell Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.33 ESR1 GATA3 PGR
2 positive regulation of cell differentiation GO:0045597 9.26 CDX2 GATA3
3 positive regulation of transcription, DNA-templated GO:0045893 9.26 CDH1 CDX2 ESR1 GATA3
4 uterus development GO:0060065 8.62 ESR1 GATA3

Molecular functions related to Gastric Signet Ring Cell Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding GO:0001077 9.43 ESR1 GATA3 PGR
2 core promoter sequence-specific DNA binding GO:0001046 9.32 ESR1 GATA3
3 nuclear receptor activity GO:0004879 9.16 ESR1 PGR
4 steroid binding GO:0005496 8.96 ESR1 PGR
5 sequence-specific DNA binding GO:0043565 8.92 CDX2 ESR1 GATA3 PGR

Sources for Gastric Signet Ring Cell Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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