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Gastric Ulcer malady
24 drugs, 95 genes, 4 tissues, 950 related diseases, 26 phenotypes, 113 articles, clinical trials.

Summaries for Gastric Ulcer

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44Wikipedia, 22MalaCards
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Wikipedia: A peptic ulcer, also known as PUD or peptic ulcer disease, is the most common ulcer of an area of the...44 more...

MalaCards: Gastric Ulcer, also known as chronic gastric ulcer without hemorrhage and without perforation but with obstruction (disorder), is related to duodenal ulcer and gastritis. An important gene associated with Gastric Ulcer is HRH2 (histamine receptor H2), and among its related pathways are Glioma Invasiveness and Ras Pathway. The drugs calcium (as calcium carbonate) and sucralfate and the compounds glucose and cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include colon, t cells and b cells, and related mouse phenotypes are endocrine/exocrine gland and hematopoietic system.

Aliases & Descriptions for Gastric Ulcer

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6Disease Ontology, 32Novoseek , 43UMLS, 40SNOMED-CT, 27NCIt, 19ICD9CM, 24MeSH
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Aliases & Descriptions:

gastric ulcer 6 32 43
chronic gastric ulcer without hemorrhage and without perforation but with obstruction (disorder) 6
acute gastric ulcer without hemorrhage, without perforation and without obstruction (disorder) 6
acute gastric ulcer with hemorrhage and with perforation but without obstruction (disorder) 6
chronic gastric ulcer without hemorrhage and without perforation but with obstruction 6
acute gastric ulcer with hemorrhage, with perforation and with obstruction (disorder) 6
acute gastric ulcer without hemorrhage, without perforation and without obstruction 6
acute gastric ulcer with hemorrhage and perforation, without mention of obstruction 6
acute gastric ulcer with hemorrhage and with perforation but without obstruction 6
acute gastric ulcer with hemorrhage and perforation, with obstruction 6
chronic gastric ulcer without hemorrhage and without perforation 6
acute gastric ulcer with hemorrhage and perforation (disorder) 6
acute gastric ulcer with perforation and obstruction (disorder) 6
acute gastric ulcer with hemorrhage and obstruction (disorder) 6
acute gastric ulcer without hemorrhage and without perforation 6
acute gastric ulcer with hemorrhage and perforation (disorder) 6
acute gastric ulcer with perforation, with obstruction 6
acute gastric ulcer with hemorrhage, with obstruction 6
acute gastric ulcer with haemorrhage and perforation 6
acute gastric ulcer with perforation and obstruction 6
chronic gastric ulcer without mention of hemorrhage 6
acute gastric ulcer with hemorrhage and perforation 6
acute gastric ulcer with hemorrhage and obstruction 6
acute gastric ulcer without mention of hemorrhage 6
perforation, without mention of obstruction 6
acute gastric ulcer with perforation 6
perforation, with obstruction 6
bleeding acute gastric ulcer 6
chronic gastric ulcer 43
acute gastric ulcer 43

Related Diseases for Gastric Ulcer

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13GeneCards, 14GeneDecks
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Diseases related to gastric ulcer by text searches and GeneDecks gene sharing:

(show top 50)    (show all 947)
idRelated DiseaseScoreTop Affiliating Genes
1duodenal ulcer33.5S100A8, IL1RN, HRH2, GAST
2gastritis32.6S100A8, IL1RN, IL8, GHRL, NOS2, GAST
3atrophic gastritis29.0S100A8, MET, IL1RN, GHRL, SST, ODC1
4portal hypertension28.6ALB, SST, NOS3, EDN1
5arthritis28.3MMP3, IL1B, IL6, IL8, TNF
6duodenitis20.2PCNA, MUC5AC, S100A8, MPO, MMP3, MMP7
7blindness18.9VWF, SERPINE1, VEGFA, MPO, CD36, ITGAL
8gastric cancer16.6VWF, PCNA, SERPINE1, VEGFA, BMP6, BDKRB2
9hypertension15.2VWF, PCNA, SERPINE1, VEGFA, BMP6, BDKRB1
10hypoxia14.7VWF, PCNA, SERPINE1, VEGFA, BMP6, BDKRB2
11peutz-jeghers syndrome14.0MUC5AC, TFF1, TFF2, GAST
12stomach disease13.9HRH2, PTGS2, PTGS1
13gastrointestinal system disease13.9S100A8, CCKBR, GHRL, TRPV1, LTF, GAST
14embryonal cancer13.8FGF2, EGF, TGFA, NUDT6
15hepatitis13.8VWF, PCNA, SERPINE1, VEGFA, BMP6, MPO
16pancreatitis13.8VWF, PCNA, SERPINE1, VEGFA, BMP6, MUC5AC
17gingival overgrowth13.8MMP1, FN1, FGF7
18familial medullary thyroid carcinoma13.7CCKBR, CALCA, GHRL, SST, TFF1, GAST
19chronic ulcer of skin13.7CD36, MMP1, FGF2, EGF
20apudoma13.7CALCA, SST, GAST
21doxorubicin induced cardiomyopathy13.7MET, MAPK14, EDN1, HGF
22myoma13.7PCNA, GSR, FGF2, CALCA, PTGS2, DCN
23arteriosclerosis obliterans13.7ITGAL, FGF2, EDN1, HGF
24bronchitis13.6BDKRB2, MAPK14, GHRL, SRF, TGIF1
25respiratory failure13.6MUC5AC, CCL5, CAT, PTGS1, RNASE3, G6PD
26chronic rhinitis13.6MPO, CALCA, RNASE3, EDN1
27choledochal cyst13.6MMP1, PTGS2, SST, NOS2
28follicular adenoma13.6MMP1, MET, CALCA, TFF3, HGF
29cryptosporidiosis13.6CCL5, CAT, PTGES3, LTF
30neuronitis13.6VWF, PCNA, SERPINE1, VEGFA, BMP6, BDKRB1
31congenital heart defect13.6BDKRB2, MMP3, GSR, IL1RN, MAPK14, SRF
32alcoholism13.5GSR, IL1RN, CCKBR, HNMT, GHRL, G6PD
33lacrimal duct obstruction13.5MUC5AC, MMP3, FGF7, PTGS1, RNASE3, TKT
34proliferative vitreoretinopathy13.5BMP6, FN1, FGF2, MET, TGFBR2, NUDT6
35mucoepidermoid carcinoma13.5PCNA, MUC5AC, CALCA, NOS2, TGFBR2
36rasmussen encephalitis13.5BMP6, GSR, SST, NOS2
37extrapulmonary tuberculosis13.5IL1B, IL1RN, TLR2, ADA
38factor vii deficiency13.5VEGFA, MUC5AC, FGF2, SST, NUDT6
39hypophosphatemia13.4FGF2, FGF7, ALB, CALCA, SRF
40breast cancer13.4BMP6, CDK2, HSPB1, PTGS2, ODC1, NRG1
41localized scleroderma13.4CD36, MMP1, DCN
42diabetic cataract13.4GSR, CAT, G6PD, SOD1
43carotid artery disease13.4MMP1, MMP7, CCL5, PLAT
44hepatocellular carcinoma (fibrolamellar variant)13.4MMP2, MMP9, MET, HGF
45dry eye syndrome13.4MUC5AC, FGF7, IL6, LTF, HGF
46benign tumors13.4PCNA, MET, HSPB1, HIF1A, TFF1, NUDT6
47thoracic aortic aneurysm13.4MMP1, MMP2, TGFBR2
48hemorrhagic shock and encephalopathy syndrome13.4MPO, ITGAM, NOS2, NOS3
49bone cancer13.4BDKRB1, CD36, IL1B, IL1RN, CALCA, TRPV1
50chronic myocardial ischemia13.4VEGFA, FGF2, ANGPT1, TEK, NOS3

Graphical network of the top 20 diseases related to gastric ulcer:



Graphical network of diseases related to gastric ulcer

Clinical Features for Gastric Ulcer

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Drugs & Therapeutics for Gastric Ulcer

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

Search CenterWatch for gastric ulcer

Drug clinical trials:

Search ClinicalTrials for gastric ulcer

Search NIH Clinical Center for gastric ulcer

Search CenterWatch for gastric ulcer

Inferred drug relations via UMLS/NDF-RT:

43 28 aluminum (as hydroxide), aluminum carbonate, aluminum carbonate basic, aluminum hydroxide, aluminum hydroxide gel, aluminum hydroxide gel,dried, aluminum/magnesium hydroxide, atropine, atropine methylnitrate, atropine sulfate, calcium (as calcium carbonate), calcium (as carbonate), calcium carbonate, calcium carbonate pwdr [va product], calcium gluceptate, cat's claw, dihydroxyaluminum sodium carbonate, lansoprazole, magaldrate, magnesium hydroxide, milk of magnesia [va product], omeprazole, omeprazole magnesium, sucralfate

Genetic Tests for Gastric Ulcer

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Anatomical Context for Gastric Ulcer

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22MalaCards
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MalaCards organs/tissues related to gastric ulcer:

22
Colon, T cells, B cells, Endothelial

Phenotypes for genes affiliated with Gastric Ulcer

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25MGI
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MGI Mouse Phenotypes related to gastric ulcer:

25 (show all 26)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1endocrine/exocrine gland phenotypeMP:000537910.5BDKRB2, NRG1, PFKM, TLR2, TKT, TFF2
2hematopoietic system phenotypeMP:000539710.4PCNA, BDKRB2, FGF2, FGF7, PTGER2, ADA
3respiratory system phenotypeMP:000538810.3CALCA, GIT1, SRF, ADA
4craniofacial phenotypeMP:000538210.1RGMA, TGIF1, EDN1
5embryogenesis phenotypeMP:00053809.9RGMA, CXCR4, G6PD, NRG1, ODC1, PTPRB
6other phenotypeMP:00053959.8TLR2, NOS3, NOS2, PTGS1, PTGS2, PTGER2
7integument phenotypeMP:00107719.5PTGS1, NRG1, EGF, TLR2, TGFA, PTGES3
8renal/urinary system phenotypeMP:00053678.9INS, MET, CCKBR, CASP3, TRPV1, PTGS1
9no phenotypic analysisMP:00030128.5SRF, SST, PTGS2, PTGER2, TP53, TRPV1
10nervous system phenotypeMP:00036318.3HRH2, ADH7, RGMA, CXCR4, GJB1, GIT1
11reproductive system phenotypeMP:00053898.1TNF, PTGS2, PTGS1, NRG1, NOS2, CASP3
12behavior/neurological phenotypeMP:00053867.7PLAT, NRG1, SRF, SST, PTGS1, NOS2
13immune system phenotypeMP:00053877.6VWF, BDKRB1, BDKRB2, MUC5AC, ITGAL, SRF
14normal phenotypeMP:00028737.6GIT1, GHRL, SST, SRF, HIF1A, TLR2
15liver/biliary system phenotypeMP:00053707.3NOS3, HIF1A, TLR2, SOD1, ADA, TP53
16digestive/alimentary phenotypeMP:00053817.2VWF, VEGFA, BDKRB2, MUC5AC, CD36, MMP7
17growth/size phenotypeMP:00053786.1SERPINE1, BMP6, CDK2, MMP7, INS, MET
18adipose tissue phenotypeMP:00053756.1PTGS2, NOS2, NOS3, TLR2, TKT, TGFA
19mortality/agingMP:00107686.0VEGFA, BDKRB1, BDKRB2, S100A8, CD36, MET
20tumorigenesisMP:00020065.9SERPINE1, CDK2, TP53, TNF, PTGER2, PTGS2
21skeleton phenotypeMP:00053905.9VEGFA, BMP6, BDKRB2, MMP2, MMP3, PLAT
22vision/eye phenotypeMP:00053915.2NOS3, NOS2, PLAT, NRG1, PTGS2, EGF
23muscle phenotypeMP:00053694.9TLR2, TGFA, TGFBR2, DCN, CXCR4, SOD1
24cellular phenotypeMP:00053843.6BDKRB2, MAPK14, CCL5, IGF1, CASP3, CAT
25homeostasis/metabolism phenotypeMP:00053762.8TLR2, TGFBR2, TGIF1, TFF2, TFF3, DCN
26cardiovascular system phenotypeMP:00053852.5PTPRB, TGFBR2, TGIF1, CXCR4, SOD1, HGF

Publications for genes affiliated with Gastric Ulcer

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35PubMed
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Articles related to gastric ulcer:

(show top 50)    (show all 113)
idTitleAuthorsYearAffiliating Genes
1Pro-ulcer effects of resveratrol in mice with indomet hacin-induced gastric ulcers are reversed by L-arginine. (20067468)Guha P.... Bandyopadhyay S.K.2010NOS3, MPO, PTGS2
2Ameliorative effects of telmisartan in diabetic rats with indomethacin-induced gastric ulceration. (20399771)Fouad A.A.... Gomaa W.2010SOD1, CASP3, CAT
3Involvement of orexigenic peptides in the mechanism o f gastric mucosal integrity and healing of chronic gastric ulcers. (20166991)Szlachcic A.... Pawlik W.W.2010GHRL
4Autoimmune pancreatitis associated with high prevalence of gastric ulcer independent of Helicobacter pylori infection status. (19276869)Chang M.C.... Wong J.M.2009TNF
5Gastric mucosal levels of prostaglandins and leukotrienes in patients with gastric ulcer after treatment with rabeprazole in comparison to treatment with ranitidine. (17380018)Okazaki M.... Ito S.2007PTGS1, PTGS2
6Hydrogen peroxide-mediated downregulation of matrix m etalloprotease-2 in indomethacin-induced acute gastric ulceration is blocked by melatonin and other antioxidants. (16934674)Ganguly K.... Swarnakar S.2006MMP2
7Genetic variants in matrix metalloproteinase genes are associated with development of gastric ulcer in H. Pylori infection. (16405530)Hellmig S.... Schreiber S.2006MMP3, MMP7, MMP9
8Roles of platelets and proteinase-activated receptors in gastric ulcer healing. (16184414)Perini R.... Ma L.2005EPRS
9Effects of antisecretory agents on angiogenesis during healing of gastric ulcers. (16082584)Akimoto M.... Yamashita K.2005CXCR4, C19orf10
10Recent advances in gastric ulcer therapeutics. (16188503)Wallace J.L.2005PTGS2
11Haplotype analysis of the CD11 gene cluster in patients with chronic Helicobacter pylori infection and gastric ulcer disease. (15730520)Hellmig S.... Schreiber S.2005ITGAM, ITGAL, ITGAX
12Combination of enprostil and cimetidine is more effec tive than cimetidine alone in treating gastric ulcer: prospective multicenter r andomized controlled trial. (16334808)Murata H.... Saito I.2005HRH2
13Microsomal prostaglandin E synthase (mPGES)-1, mPGES-2 and cytosolic PGES expression in human gastritis and gastric ulcer tissue. (15531909)Gudis K.... Sakamoto C.2005PTGS2, PTGES, PTGES3
14Eosinophil infiltration, gastric juice and serum eosinophil cationic protein levels in Helicobacter pylori-associated chronic gastritis and gastric ulcer. (15770055)Aydemir S.A.... Ustundag Y.2004RNASE3
15A comparison study of gastric cancer risk in patients with duodenal and gastric ulcer: roles of gastric mucosal histology and p53 codon 72 polymorphism. (15104366)Zhang Z.W.... Holly J.2004TP53
16Helicobacter pylori vacuolating cytotoxin, VacA, is responsible for gastric ulceration. (15671482)Wada A.... Hirayama T.2004PTPRB
17Effect of rebamipide on acetic acid-induced gastric ulcer in rats: involvement of hepatocyte growth factor. (12678329)Udagawa A.... Murawaki Y.2003MET, HGF, IL6
18Association of polymorphisms of interleukin-1 beta gene and Helicobacter pylori infection with the risk of gastric ulcer. (12239970)Chang Y.T.... Lin J.T.2002IL1B, IL1RN
19Divergent effects of new cyclooxygenase inhibitors on gastric ulcer healing: Shifting the angiogenic balance. (12232050)Ma L.... Wallace J.L.2002VEGFA, PTGS2
20Antiangiogenic effect of a highly selective cyclooxygenase-2 inhibitor on gastric ulcer healing in rats. (12217640)Guo J.S.... Leung Koo M.W.2002FGF2, PTGS2
21Effects of omeprazole and famotidine on fibroblast growth factor-2 during artificial gastric ulcer healing in humans. (11943947)Esaki M.... Fujishima M.2002FGF2
22Effects of NSAIDs on cryoprobe-induced gastric ulcer healing in rats. (11736732)Tibble J.... Bjarnason I.2001PTGS2
23Up-regulation of cyclooxygenase-1 and -2 in human gastric ulcer. (11136275)To K.F.... Sung J.J.2001PTGS1, PTGS2
24Expression of hepatocyte growth factor and c-met receptor in gastric mucosa during gastric ulcer healing. (10672830)Hori K.... Kawasaki H.2000HGF
25Localisation of cyclooxygenase 1 and cyclooxygenase 2 in Helicobacter pylori related gastritis and gastric ulcer tissues in humans. (10807888)Tatsuguchi A.... Kobayashi M.2000PTGS1, PTGS2
26Higher concentration of matrix-metalloproteinase 1 (interstitial collagenase) in H. pylori-compared to NSAID-induced gastric ulcers. (11132534)Menges M.... Stallmach A.2000MMP1
27Genotypes of Helicobacter pylori obtained from gastric ulcer patients taking or not taking NSAIDs. (10364014)Li L.... Go M.F.1999S100A8
28Increased expression of inducible nitric oxide synthase and peroxynitrite in Helicobacter pylori gastric ulcer. (10515582)Sakaguchi A.A.... Ishii H.1999NOS2
29Increase in apoptosis and decrease in ornithine decarboxylase activity of the gastric mucosa in patients with atrophic gastritis and gastric ulcer after successful eradication of Helicobacter pylori. (10483998)Hirasawa R.... Sakai N.1999ODC1
30Giant gastric ulcer: its natural history and outcome in the H2RA era. (10606307)Raju G.S.... Beresford J.1999HRH2
31Helicobacter pylori infection affects gastric ulcer healing in Japanese monkeys. (9840013)Okui M.... Shimoyama T.1998S100A8
32Relationship between recurrence of gastric ulcer and the microcirculation. (9595526)Akimoto M.... Yokoyama I.1998CCL5
33Roles of hepatocyte growth factor and its receptor Met during gastric ulcer healing in rats. (9394725)Schmassmann A.... Halter F.1997HGF
34Basic fibroblast growth factor increases constitutive nitric oxide synthase during healing of rat gastric ulcers. (9479638)Akiba Y.... Ishii H.1997FGF2, NOS2
35Matrix metalloproteinase gene expression in chronic gastric ulcer: a potential role of eosinophils in perforation. (9479634)Otani Y.... Kitajima M.1997MMP1
36Expression of vascular endothelial growth factor at the human gastric ulcer margin and in cultured gastric fibroblasts: a new angiogenic factor for gastric ulcer healing. (9177300)Takahashi M.... Omata M.1997VEGFA
37Healing with basic fibroblast growth factor is associated with reduced indomethacin induced relapse in a human model of gastric ulceration. (9071932)Hull M.A.... Hawkey C.J.1997FGF2
38Study of the repairing process of gastric ulcer using multivariate analysis of bFGF-positive cells, haemodynamics, PAS-positive mucus amount and glandular index in the gastric mucosa. (8912129)Terasaki T.... Watanabe A.1996FGF2
39Effects of oxygen radical scavengers on the quality o f gastric ulcer healing in rats. (8774996)Naito Y.... Kondo M.1995SOD1
40Basic fibroblast growth factor treatment for non-steroidal anti-inflammatory drug associated gastric ulceration. (8549933)Hull M.A.... Hawkey C.J.1995FGF2
41Gastric ulcer treatment with intravenous human epidermal growth factor: a double-blind controlled clinical study. (7881024)Itoh M.... Matsuo Y.1994EGF
42Prostaglandins: viable therapy in gastric ulceration. (8441926)Janusz A.G.... Janusz A.J.1993HRH2
43The role of eradication of Helicobacter pylori in he aling and recurrence of gastric ulcer (7904321)Fukuda Y.... Shimoyama T.1993HRH2
44Cell proliferation kinetics in acetic acid-induced gastric ulcer evaluated by immunohistochemical staining of proliferating cell nuclear antigen. (7904283)Kitajima T.... Inoue K.1993PCNA
45Long-term follow-up study after pylorus-preserving gastrectomy for gastric ulcer (1870568)Fukushima K.... Matsuno S.1991GAST
46Basal and somatostatin-stimulated gastric intralumina l prostaglandin E2 in patients with gastric ulcer and with gastric adenocarcino ma. (1973675)Materia A.... Basso N.1990SST
47Effect of calcitonin on gastric emptying and on postprandial gastrin and insulin release in patients with type I gastric ulcer. (2215826)Jonderko G.... Gol/ab T.1990CALCA, GAST
48Effects of orally administered human epidermal growth factor on natural and delayed healing of acetic acid-induced gastric ulcers in rats. (2308236)Kuwahara Y.... Okabe S.1990EGF
49Gastrin- and somatostatin-immunoreactive cells of the antral mucosa in patients with duodenal or gastric ulcers. An immunocytochemical study. (1982175)Hacker G.W.... Adam H.1990SST, GAST
50Prostaglandins and gastric ulcers: from seminal vesicle to misoprostol (Cytotec). (1976294)Feldman M.1990HRH2

Expression for genes affiliated with Gastric Ulcer

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Gastric Ulcer

Pathways for genes affiliated with Gastric Ulcer

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36QIAGEN, 3Cell Signaling Technology, 20KEGG, 10EMD Millipore, 41Thomson Reuters
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Pathways related to gastric ulcer according to GeneDecks:

(show top 50)    (show all 131)
idPathwayScoreTop Affiliating Genes
1Glioma Invasiveness3610.2BMP6, ITGAL, ITGAM, ITGAX, FGF2, FGF7
2Ras Pathway3610.1EGF, ITGAM, FGF2, FGF7, MET, TEK
3Actin-Based Motility by Rho Family GTPases3610.0FGF7, ITGAX, ITGAM, ITGAL, IGF1, NRG1
4Breast Cancer Regulation by Stathmin13610.0TGFA, HGF, NRG1, TEK, FGF2, NUDT6
5PTEN Pathway369.8ITGAX, TP53, ITGAL, NUDT6, HGF, EGF
6Regulation of eIF4 and p70S6K369.6ITGAM, ITGAL, ITGAX, FGF7, IL6, CCL5
7eNOS Signaling369.6BDKRB2, BDKRB1, CASP3, MET, TEK, NRG1
8Paxillin Interactions369.5MET, FGF7, ITGAX, ITGAM, EGF, FGF2
914-3-3 Induced Intracellular Signaling369.5TNF, IGF1, TEK, NUDT6, NRG1, MAPK14
10ILK Signaling369.3NUDT6, ITGAX, TGFA, HIF1A, EGF, NRG1
11Endothelin-1 Signaling Pathway369.0EDN1, TEK, CASP3, CCL5, ANGPT1, IL6
12Angiogenesis39.0MMP2, MMP7, MMP9, FGF2, TEK, PTGS2
13JNK Pathway369.0NRG1, TEK, TP53, ANGPT1, IL6, FGF7
14ERK Signaling368.7IL6, IL1B, FGF7, FN1, ITGAX, ITGAM
15Akt Signaling368.7ITGAL, ITGAM, ITGAX, FGF7, MET, IL6
16Amoebiasis208.5IL1B, IL6, IL8, NOS2, HSPB1, TLR2
17PPAR Pathway368.5FGF2, FGF7, MET, IL6, MAPK14, ITGAX
18Cell adhesion ECM remodeling108.5MMP1, MMP9, MMP7, MMP3, SERPINE1, FN1
19Rac1 Pathway368.5BMP6, FGF7, ITGAX, NUDT6, IL6, MET
20Cell adhesion_ECM remodeling418.5MMP9, PLAT, IGF1, IL8, FN1, MMP7
21Rho Family GTPases368.4CCL5, HGF, TEK, IGF1, IL8, IL1B
22Pathways in cancer208.4FGF2, TGFA, TGFBR2, HGF, HIF1A, EGF
23DHA Signaling368.3NUDT6, TGFA, EGF, NRG1, CASP3, HGF
24p53 Mediated Apoptosis368.2BMP6, HGF, NUDT6, TGFA, TP53, FGF2
25Mitochondrial Apoptosis368.1HGF, NUDT6, FGF2, TGFA, EGF, MET
26p70S6K Signaling368.1TGFA, MAPK14, EGF, EEF2K, HGF, IGF1
27Colorectal Cancer Metastasis368.1IL6, MMP9, EGF, MMP7, MMP2, CASP3
28Malaria208.1HGF, TLR2, IL8, MET, IL6, IL1B
29Rheumatoid arthritis208.0VEGFA, ITGAL, MMP1, MMP3, IL1B, IL6
30mTOR Pathway368.0MAPK14, HIF1A, HGF, BMP6, NUDT6, TGFA
31NF-KappaB (p50-p65) Pathway368.0FGF2, IL6, IGF1, NRG1, EGF, TLR2
32NF-KappaB Family Pathway368.0NUDT6, TGFA, TLR2, EGF, TNF, NRG1
33Immune response_MIF in innate immunity response417.9MAPK14, TP53, TNF, PTGS2, NOS2, IL8
34Immune response IL-1 signaling pathway107.9SERPINE1, EDN1, NOS2, PTGS2, IL6, TNF
35Apoptotic Pathways in Synovial Fibroblasts367.9HGF, FGF2, NRG1, TNF, MET, FGF7
36Immune response_IL-1 signaling pathway417.9IL1B, SERPINE1, IL8, MAPK14, TNF, PTGS2
37Immune response MIF in innate immunity response107.9NOS2, IL1B, IL6, IL8, MAPK14, TP53
38TGF-Beta Pathway367.9TGFA, EGF, HGF, NUDT6, TGFBR2, MET
39Chagas disease (American trypanosomiasis)207.9IL8, SERPINE1, IL6, TLR2, TGFBR2, NOS2
40Molecular Mechanisms of Cancer367.8HGF, NUDT6, TGFBR2, TGFA, HIF1A, EGF
41Estrogen Pathway367.7MAPK14, IL6, HGF, MET, TGFA, EGF
42JAK-STAT Pathway367.7HGF, BMP6, FGF2, FGF7, MET, IL1B
43Cellular Apoptosis Pathway367.7HGF, BMP6, TGFA, NUDT6, EGF, NRG1
44MAPK Family Pathway367.3IL6, IL8, ANGPT1, MAPK14, CCL5, IGF1
45Pancreatic Adenocarcinoma367.3BMP6, EGF, TGFA, TGFBR2, NUDT6, HGF
46PAK Pathway367.2NRG1, NUDT6, TGFA, TNF, BMP6, FGF2
47MAPK Signaling367.2MAPK14, IL1B, MET, FGF7, FGF2, FN1
48Antioxidant Action of Vitamin-C367.2ANGPT1, IL8, IL6, IL1B, MET, FGF7
49Tec Kinases Signaling367.0BMP6, ITGAL, ITGAM, HGF, CCL5, ANGPT1
50p38 Signaling366.6NRG1, BMP6, FGF2, FGF7, TEK, TNF

Compounds for genes affiliated with Gastric Ulcer

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32Novoseek , 34PharmGKB, 9DrugBank, 18HMDB, 42Tocris Bioscience
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Compounds related to gastric ulcer according to GeneDecks:

(show top 50)    (show all 540)
idCompoundScoreTop Affiliating Genes
1glucose32 10.7MDH2, HSPB1, PTGES, TFF1, NUDT6, EEF2K
2cyclophosphamide32 34 9 9 13.6ITGAL, LTF
3nadph32 18 11.3BDKRB2, MDH2, CYP2C19, H6PD, HIF1A, ADH7
4egcg32 10.1CDK2, MAPK14, CCL5, CAT, PTGS1, ODC1
5l-nmma32 10.0BDKRB2, IL1RN, CAT, GHRL, NOS2, EDN1
6bromodeoxyuridine32 9.9PCNA, BMP6, CDK2, FGF2, FGF7, PTGER2
7ethanol32 34 9 18 9 13.7BDKRB2, MUC5AC, ITGAL, ITGAM, ANGPT1, CCL5
8progesterone32 42 9 18 9 13.6PCNA, CDK2, MMP7, MET, HSPB1, GJB1
9h2o232 9.5VWF, MPO, ITGAL, ITGAM, IL1RN, MDH2
10imatinib32 34 9 9 12.4VEGFA, BMP6, CDK2, ITGAM, FN1, FGF7
11dmso32 9.4BMP6, BDKRB2, MUC5AC, CD36, ITGAM, MMP3
12rapamycin32 42 10.3VEGFA, CDK2, FN1, INS, FGF7, MET
1312-o-tetradecanoylphorbol 13-acetate32 9.2BMP6, ITGAM, MMP2, MMP3, MMP9, FGF7
14hyaluronic acid32 18 10.0BMP6, CD36, ITGAL, MMP1, MMP3, FN1
15ndga32 8.9MMP3, IL1B, HSPB1, CAT, TNF, PTGS2
16atp32 8.7BDKRB2, MUC5AC, CDK2, ITGAM, MMP3, FGF7
17acetylcholine32 9 18 9 11.7VWF, BMP6, MPO, MMP3, FGF7, CCKBR
18pge232 8.7BDKRB2, MUC5AC, MMP1, MMP3, FN1, GSR
19epinephrine32 9 18 9 11.6BMP6, ITGAM, MMP1, MMP2, MMP9, INS
20thapsigargin32 42 9.4PCNA, SERPINE1, BDKRB2, CD36, ITGAL, MAPK14
21fluvastatin32 34 9 9 11.3VWF, SERPINE1, ITGAL, MMP1, MMP9, IL6
22fmlp32 8.3MPO, ITGAL, ITGAM, ITGAX, FN1, IL1B
23candesartan32 9 9 10.3SERPINE1, VEGFA, BDKRB2, MMP1, MMP2, ALB
24s-nitroso-n-acetylpenicillamine32 8.3FN1, IL1B, IL8, MAPK14, CASP3, CAT
25arachidonic acid32 9 18 9 11.2VWF, BDKRB2, S100A8, ITGAM, ITGAX, FGF7
26ibmx32 8.1CDK2, MMP2, FN1, INS, FGF2, IL1B
27ribonucleic acid32 7.8BMP6, MUC5AC, MMP1, MMP2, MMP3, MMP7
28glutamine32 7.8VWF, PCNA, BMP6, CDK2, CD36, ITGAM
29tamoxifen32 34 9 9 10.6PCNA, VEGFA, BMP6, CDK2, FGF7, IGF1
30heparin32 9 18 9 10.5VWF, SERPINE1, MPO, CDK2, CD36, ITGAL
31calcium32 9 18 9 10.4VWF, BDKRB1, BDKRB2, MUC5AC, S100A8, MPO
32butyrate32 7.4PCNA, BMP6, MPO, CDK2, ITGAL, ITGAX
33cysteine32 7.4PCNA, BDKRB2, MUC5AC, S100A8, ITGAM, MMP1
34ly29400232 7.3VEGFA, ITGAM, MMP2, MMP9, FN1, FGF2
35ibuprofen32 9 18 9 10.2BMP6, MMP1, MMP2, MMP3, IL1B, IL1RN
36superoxide32 18 8.0S100A8, MPO, ITGAL, ITGAM, ITGAX, GSR
37creatinine32 7.0VWF, PCNA, BMP6, BDKRB2, S100A8, MPO
38herbimycin a32 42 7.5BMP6, CDK2, CD36, MMP1, MMP2, MMP9
39pdtc32 6.4ITGAX, MMP1, MMP2, MMP9, MET, IL1B
40cholesterol32 9 18 9 9.2VWF, SERPINE1, BDKRB1, MUC5AC, S100A8, CDK2
41estrogen32 6.2VWF, PCNA, SERPINE1, MUC5AC, CD36, MMP1
42thymidine32 18 7.2PCNA, BMP6, CDK2, ITGAM, FN1, FGF2
43lipid32 6.1SERPINE1, BDKRB2, S100A8, CDK2, ITGAL, ITGAM
44vitamin d32 6.1SERPINE1, BMP6, CDK2, CD36, ITGAM, MMP3
45methotrexate32 34 42 9 9 9.7PCNA, SERPINE1, BMP6, MUC5AC, S100A8, MMP1
46hydrocortisone32 9 9 7.6BMP6, CD36, MMP1, MMP2, INS, FGF2
47alanine32 5.4VWF, PCNA, BMP6, BDKRB2, S100A8, CDK2
48vegf32 5.2VWF, PCNA, SERPINE1, BDKRB2, MPO, CDK2
49pd 98,05932 4.7SERPINE1, BMP6, BDKRB2, MUC5AC, CDK2, ITGAM
50retinoic acid32 42 18 6.0VWF, SERPINE1, BMP6, S100A8, MPO, CDK2

GO Terms for genes affiliated with Gastric Ulcer

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12Gene Ontology
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Cellular components related to gastric ulcer according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301419.2TFF3, LTF, PLAT, GHRL, IL1B, INS
2external side of plasma membraneGO:0098979.0ADA, CXCR4, TGFBR2, TLR2, TNF, ITGAX
3proteinaceous extracellular matrixGO:0055788.8FN1, MMP9, MMP7, MMP3, MMP2, MMP1
4cell surfaceGO:0099868.6ADA, CXCR4, TGFA, TLR2, PLAT, TEK
5platelet alpha granule lumenGO:0310938.6HGF, EGF, ALB, IGF1, FN1, VEGFA
6plasma membraneGO:0058867.0NOS3, PTGS1, PTGER2, TEK, TNF, HRH2
7cytoplasmGO:0057376.7NOS3, NOS2, PLAT, NRG1, SRF, PTGS1
8extracellular regionGO:0055764.3GAST, CCL5, ANGPT1, IL8, IL6, IL1B
9extracellular spaceGO:0056153.5HGF, SERPINE1, IL6, IL1RN, IL1B, MET

Biological processes related to gastric ulcer according to GeneDecks:

(show top 50)    (show all 66)
idNameGO IDScoreTop Affiliating Genes
1prostaglandin biosynthetic processGO:00151610.6EDN1, PTGS1, PTGES3, PTGS2, PTGES
2digestionGO:00758610.6TFF3, TFF2, TFF1, SST, CCKBR, MUC5AC
3positive regulation of smooth muscle contractionGO:04598710.6ADA, EDN1, SRF, PTGS1, PTGS2
4positive chemotaxisGO:05091810.4CCL5, ANGPT1, FGF7, FGF2, VEGFA
5leukocyte migrationGO:05090010.1TEK, ANGPT1, FN1, MMP1, ITGAX, ITGAM
6regulation of cell proliferationGO:04212710.1TGFBR2, NOS2, PTGS1, PTGER2, GHRL, MMP7
7placenta developmentGO:00189010.0ADA, SOD1, DCN, MET, VWF
8collagen catabolic processGO:03057410.0MMP9, MMP7, MMP3, MMP2, MMP1
9positive regulation of cell divisionGO:05178110.0TGFA, CAT, IL1B, FGF7, FGF2, VEGFA
10muscle cell homeostasisGO:04671610.0SOD1, HIF1A, PFKM, SRF
11elevation of cytosolic calcium ion concentrationGO:00720410.0CXCR4, EDN1, GHRL, CALCA, CCKBR, IL1B
12positive regulation of cerebellar granule cell precursor proliferationGO:02194010.0EGF, IGF1, FGF2
13extracellular matrix disassemblyGO:0226179.9MMP9, MMP7, MMP3, MMP2, MMP1
14positive regulation of fever generationGO:0316229.9PTGS2, TNF, CCL5, IL1B
15cell surface receptor signaling pathwayGO:0071669.9EDN1, SST, TRPV1, CCKBR, MAPK14, MET
16response to lipopolysaccharideGO:0324969.8DCN, EDN1, PTGS2, PTGER2, MMP9, S100A8
17embryo implantationGO:0075669.8SOD1, PTGS2, CALCA, IL1B, MMP9
18wound healingGO:0420609.8DCN, TGFA, NRG1, IL1B, FGF7, FGF2
19agingGO:0075689.8ADA, DCN, NOS3, PTGS1, CALCA, CCL5
20response to salt stressGO:0096519.6TNF, TP53, CCL5, BDKRB2
21lipopolysaccharide-mediated signaling pathwayGO:0316639.6TLR2, NOS3, TNF, CCL5, MAPK14, IL1B
22chronic inflammatory response to antigenic stimulusGO:0024399.6TNF, IL1RN, IL1B
23cellular response to interleukin-1GO:0713479.5HIF1A, EDN1, CCL5, IL8, MMP9
24positive regulation of phosphatidylinositol 3-kinase cascadeGO:0140689.5HGF, TEK, CAT, IGF1, CCL5, ANGPT1
25response to heatGO:0094089.5SOD1, NOS3, SST, CALCA, IL1B, MMP9
26positive regulation of nitric oxide biosynthetic processGO:0454299.4TLR2, EDN1, PTGS2, TNF, IL1B, INS
27activation of MAPK activityGO:0001879.3HGF, SOD1, CXCR4, TGFA, TNF, GHRL
28response to hyperoxiaGO:0550939.2NOS3, CAT, MMP9, SERPINE1
29positive regulation of protein kinase B signaling cascadeGO:0518979.1NRG1, TEK, TNF, IGF1, ANGPT1, INS
30MAPK cascadeGO:0001659.1TGFA, NRG1, TNF, CCL5, IL1B, INS
31positive regulation of angiogenesisGO:0457669.0HIF1A, NOS3, TEK, CCL5, IL1B, FGF2
32positive regulation of peptidyl-serine phosphorylationGO:0331389.0TEK, TNF, ANGPT1, IL6, MET, VEGFA
33defense response to Gram-positive bacteriumGO:0508308.9TLR2, TNF, IL6, MMP7, CD36
34positive regulation of chemokine productionGO:0327228.8IL6, TNF, HIF1A, TLR2
35positive regulation of interleukin-6 productionGO:0327558.7TLR2, TNF, IL6, IL1B, CD36
36positive regulation of mitosisGO:0458408.6TGFA, EGF, EDN1, TNF, IGF1, IL1B
37angiogenesisGO:0015258.6PTPRB, NOS3, EGF, HIF1A, TGFA, TEK
38anti-apoptosisGO:0069168.5NRG1, NOS3, TGFA, SOD1, HGF, TEK
39response to drugGO:0424938.5NOS3, EDN1, TGFA, TGFBR2, TGIF1, SOD1
40response to glucocorticoid stimulusGO:0513848.5PLAT, PTGS2, TNF, HNMT, CCL5, IL6
41positive regulation of smooth muscle cell proliferationGO:0486618.4HIF1A, EDN1, PTGS2, TNF, IGF1, CCL5
42positive regulation of cell proliferationGO:0082848.4TFF2, TGFBR2, EGF, EDN1, ODC1, IGF1
43response to hypoxiaGO:0016668.3NOS2, NOS3, EDN1, HIF1A, CXCR4, ADA
44platelet degranulationGO:0025768.3HGF, SOD1, EGF, ALB, IGF1, FN1
45positive regulation of peptidyl-tyrosine phosphorylationGO:0507318.1HGF, TP53, IGF1, ANGPT1, IL6, FGF7
46inflammatory responseGO:0069547.9CCL5, CALCA, TNF, PTGS2, TLR2, CXCR4
47platelet activationGO:0301687.4ALB, SRF, EGF, SOD1, HGF, IGF1
48negative regulation of cell proliferationGO:0082857.3PTGES, PTGS2, SST, SRF, NOS3, TGIF1
49negative regulation of apoptotic processGO:0430666.9CASP3, CAT, GHRL, TP53, TNF, TEK
50blood coagulationGO:0075966.8HGF, IGF1, ALB, TP53, TEK, PLAT

Molecular functions related to gastric ulcer according to GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1chemoattractant activityGO:04205610.0CCL5, FGF7, FGF2, VEGFA
2NADP bindingGO:05066110.0G6PD, H6PD, NOS3, NOS2, CAT, GSR
3heme bindingGO:0200379.8NOS3, NOS2, CYP2C9, CYP2C19, PTGS1, PTGS2
4heparin bindingGO:0082019.7LTF, CCL5, FGF7, FGF2, FN1, MPO
5protein homodimerization activityGO:0428039.1ADH7, SOD1, TKT, G6PD, NOS2, SRF
6hormone activityGO:0051799.1EDN1, SST, CALCA, IGF1, INS, GAST
7protease bindingGO:0020208.9TNF, TP53, INS, BDKRB2, SERPINE1
8protein heterodimerization activityGO:0469828.7HGF, TLR2, HIF1A, TP53, MET, ITGAL
9growth factor activityGO:0080838.3VEGFA, HGF, NUDT6, TFF1, TGFA, EGF
10cytokine activityGO:0051258.3EDN1, NRG1, TNF, IL6, IL1B, FGF2
11protein bindingGO:0055153.0PFKM, NOS3, NOS2, PLAT, NRG1, SRF

Sources for Gastric Ulcer

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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