MCID: GST023
MIFTS: 57

Gastric Ulcer malady

Gastrointestinal diseases, Ear diseases categories

Aliases & Classifications for Gastric Ulcer

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Sources:
9Disease Ontology, 43Novoseek, 60UMLS, 38NCIt, 55SNOMED-CT, 27ICD9CM, 33MeSH, 25ICD10
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Gastric Ulcer, Aliases & Descriptions:

Name: Gastric Ulcer 9 43 60
Acute Gastric Ulcer with Perforation 9 60
Chronic Gastric Ulcer Without Hemorrhage and Without Perforation but with Obstruction 9
Acute Gastric Ulcer Without Hemorrhage, Without Perforation and Without Obstruction 9
Acute Gastric Ulcer with Hemorrhage and Perforation, Without Mention of Obstruction 9
Acute Gastric Ulcer with Hemorrhage and with Perforation but Without Obstruction 9
Acute Gastric Ulcer with Hemorrhage, with Perforation and with Obstruction 9
Acute Gastric Ulcer with Hemorrhage and Perforation, with Obstruction 9
Chronic Gastric Ulcer Without Hemorrhage and Without Perforation 9
Acute Gastric Ulcer Without Hemorrhage and Without Perforation 9
Acute Gastric Ulcer with Perforation, with Obstruction 9
 
Acute Gastric Ulcer with Hemorrhage, with Obstruction 9
Acute Gastric Ulcer with Haemorrhage and Perforation 9
Acute Gastric Ulcer with Perforation and Obstruction 9
Acute Gastric Ulcer with Hemorrhage and Perforation 9
Acute Gastric Ulcer with Hemorrhage and Obstruction 9
Chronic Gastric Ulcer Without Mention of Hemorrhage 9
Acute Gastric Ulcer Without Mention of Hemorrhage 9
Perforation, Without Mention of Obstruction 9
Perforation, with Obstruction 9
Bleeding Acute Gastric Ulcer 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Ear diseases


Summaries for Gastric Ulcer

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MalaCards based summary: Gastric Ulcer, also known as acute gastric ulcer with perforation, is related to esophagitis and duodenal ulcer. An important gene associated with Gastric Ulcer is HRH2 (histamine receptor H2), and among its related pathways are Prostaglandin Synthesis and Regulation and Celecoxib Pathway, Pharmacodynamics. The drugs aluminum hydroxide and aluminum hydroxide gel and the compounds 4-hydroxydiclofenac and lansoprazole have been mentioned in the context of this disorder. Affiliated tissues include endothelial, liver and heart, and related mouse phenotypes are tumorigenesis and cardiovascular system.

Related Diseases for Gastric Ulcer

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Diseases related to Gastric Ulcer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1esophagitis31.1CYP2C19, HRH2
2duodenal ulcer30.9HRH2, CYP2C19, TFF1
3atrophic gastritis30.9TFF1, ODC1
4gastroesophageal reflux30.4CYP2C19, PTGS1, HRH2
5arthritis30.3PTGS1, HRH2, FGF2
6gastritis30.3TFF1, CYP2C19, PTGS1, ODC1, CCKBR, HRH2
7peptic ulcer disease30.2HRH2, PTGS1, CYP2C19
8ischemia29.9FGF2, HRH2, HGF, NUDT6
9adenoma29.9TFF1, NUDT6, PTGER2, PTGS1, ODC1
10hepatocellular carcinoma29.7CYP2C19, CCKBR, HGF, FGF2
11breast cancer29.5TFF1, ODC1, HGF, FGF2
12leukemia29.5NUDT6, PTGS1, ODC1, CCKBR, HRH2, FGF2
13lung cancer29.3TFF1, CYP2C19, CCKBR, HGF
14gastric adenocarcinoma29.3TFF1, ODC1, CCKBR, HGF, HRH2
15stomach cancer29.2TFF1, ODC1, CCKBR, HGF, HRH2
16melanoma29.1NUDT6, PTGS1, ODC1, HGF, HRH2, FGF2
17adenocarcinoma29.0TFF1, NUDT6, PTGER2, PTGS1, ODC1, CCKBR
18duodenitis10.7
19endotheliitis10.5
20duodenogastric reflux10.5
21bile reflux10.5
22blindness10.4
23pancreatitis10.4
24h. pylori infection10.4
25hiatus hernia10.3
26stomach disease10.3PTGS1, HRH2
27anisakiasis10.3
28aneurysm10.3
29moyamoya disease10.3NUDT6, FGF2
30hepatitis10.2
31splenic abscess10.2
32pernicious anemia10.2
33gastroenteritis10.2
34hypertrophic scars10.2NUDT6, FGF2
35urticaria10.2PTGS1, HRH2
36factor vii deficiency10.2NUDT6, FGF2
37acute pancreatitis10.1
38portal hypertension10.1
39gastric lymphoma10.1
40eosinophilic gastroenteritis10.1
41bacterial gastritis10.1
42gastric dilatation10.1
43tabes dorsalis10.1
44scrub typhus10.1
45pyloric stenosis10.1
46typhus10.1
47autoimmune pancreatitis10.1
48barrett esophagus/esophageal adenocarcinoma10.1TFF1, PTGS1, ODC1
49adenomatous polyposis coli10.1ODC1, PTGS1, PTGER2
50bladder cancer, somatic10.1NUDT6, ODC1, FGF2

Graphical network of the top 20 diseases related to Gastric Ulcer:



Diseases related to gastric ulcer

Symptoms for Gastric Ulcer

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Drugs & Therapeutics for Gastric Ulcer

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Genetic Tests for Gastric Ulcer

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Anatomical Context for Gastric Ulcer

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MalaCards organs/tissues related to Gastric Ulcer:

31
Endothelial, Liver, Heart, Testes, Brain, Colon, Lung, Pancreas, Bone marrow, Bone, Spleen, Thyroid, Breast, Skin, Monocytes, Tongue

Animal Models for Gastric Ulcer or affiliated genes

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MGI Mouse Phenotypes related to Gastric Ulcer:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8FGF2, PTGS1, PTGER2, TFF1
2MP:00053857.8FGF2, HGF, CCKBR, PTGS1, PTGER2
3MP:00053767.7TFF1, PTGER2, PTGS1, CCKBR, HRH2, FGF2

Publications for Gastric Ulcer

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Articles related to Gastric Ulcer:

(show top 50)    (show all 692)
idTitleAuthorsYear
1
Splenic abscess: a rare adverse event of a benign penetrating gastric ulcer. (25841582)
2015
2
Video of the month: Hemostasis for spurting bleeding from a gastric ulcer using argon plasma coagulation. (25646906)
2015
3
Trichobezoar causing recurrent gastric ulcer and perforation. (25234936)
2014
4
Hydroxyproline, a serum biomarker candidate for gastric ulcer in rats: a comparison study of metabolic analysis of gastric ulcer models induced by ethanol, stress, and aspirin. (25125970)
2014
5
Healing effects of Musa sapientum var. paradisiaca in diabetic rats with co-occurring gastric ulcer: cytokines and growth factor by PCR amplification. (24192345)
2013
6
Antiulcer activity of water soaked Glycine max L. grains in aspirin induced model of gastric ulcer in Wistar rats. (24250141)
2013
7
Biopsy from the base and edge of gastric ulcer healing or complete healing may lead to detection of gastric cancer earlier: an 8 years endoscopic follow-up study. (22469743)
2012
8
Gastric ulcer and gastroenteritis caused by Epstein-Barr virus during immunosuppressive therapy for a child with systemic juvenile idiopathic arthritis. (22589331)
2012
9
A study on the protective activity of kefir against gastric ulcer. (22965503)
2012
10
Severe erosive esophagitis developing after gastric ulcer formation. (23024739)
2012
11
A biochemical study on the gastroprotective effect of andrographolide in rats induced with gastric ulcer. (22923868)
2011
12
Pharmacokinetic interaction between I/-acetamidocaproic acid (AACA) and cimetidine in indomethacin-induced acute gastric ulcer and control rats: inhibition of active renal secretion of AACA by cimetidine. (21250786)
2011
13
Cytomegalovirus-associated gastric ulcers in a patient with dermatomyositis treated with steroid and cyclophosphamide pulse therapy. (21915824)
2011
14
The protective effect and action mechanism of Vaccinium myrtillus L. on gastric ulcer in mice. (21290441)
2011
15
Role of activation of 5'-adenosine monophosphate-activated protein kinase in gastric ulcer healing in diabetic rats. (22068032)
2011
16
Protective effects of a gastrointestinal agent containing Korean red ginseng on gastric ulcer models in mice. (20718962)
2010
17
Appeal for proper usage of the term 'EGUS': equine gastric ulcer syndrome. (19927576)
2009
18
Equine gastric ulcer syndrome: the continuing conundrum. (19927575)
2009
19
Inhibition of the healing of gastric ulcer by glucocorticoid and its relation to proinflammatory cytokines. (19948431)
2009
20
Gastric anisakiasis associated with bleeding gastric ulcer. (18787284)
2008
21
Rebamipide, anti-gastric ulcer drug, up-regulates the induction of iNOS in proinflammatory cytokine-stimulated hepatocytes. (17936043)
2008
22
Effect of the oral absorption of benzenesulfonanilide-type cyclooxygenase-1 inhibitors on analgesic action and gastric ulcer formation. (18452178)
2008
23
Gastric ulcer after laparoscopic fundoplication for gastroesophageal reflux disease: significance of the eradication of Helicobacter pylori. (17581465)
2007
24
Impairment of gastric ulcer healing by alendronate, a nitrogen-containing bisphosphonate, in rats. (17410434)
2007
25
Genetic variants in matrix metalloproteinase genes are associated with development of gastric ulcer in H. Pylori infection. (16405530)
2006
26
Haplotype analysis of the CD11 gene cluster in patients with chronic Helicobacter pylori infection and gastric ulcer disease. (15730520)
2005
27
Perforated gastric ulcer--reappraisal of surgical options. (16180387)
2005
28
The ameliorative effect of dates (Phoenix dactylifera L.) on ethanol-induced gastric ulcer in rats. (15814265)
2005
29
Effects of rebamipide, a gastro-protective drug on the Helicobacter pylori status and inflammation in the gastric mucosa of patients with gastric ulcer: a randomized double-blind placebo-controlled multicentre trial. (12925153)
2003
30
Pneumopericardium due to intrapericardial perforation of a gastric ulcer. (12493525)
2003
31
IL-11 up-regulates Tie-2 expression during the healing of gastric ulcers in rats. (12679933)
2003
32
Laparoscopic suture repair of a perforated gastric ulcer in a severely cirrhotic patient with portal hypertension: first case report. (14626407)
2003
33
Effects of sea buckthorn (HippophaA< rhamnoides L.) seed and pulp oils on experimental models of gastric ulcer in rats. (12490224)
2002
34
Polymorphism of CYP2C19 and gastric emptying in patients with proton pump inhibitor-resistant gastric ulcers. (12235924)
2002
35
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release. (11353854)
2001
36
Ulcer-healing drugs are required after eradication of Helicobacter pylori in patients with gastric ulcer but not duodenal ulcer haemorrhage. (10930902)
2000
37
Micronutrient antioxidants in gastric mucosa and serum in patients with gastritis and gastric ulcer: does Helicobacter pylori infection affect the mucosal levels? (10875465)
2000
38
Bile reflux due to disturbed gastric movement is a cause of spontaneous gastric ulcer in W/Wv mice. (10389693)
1999
39
Recombinant human transforming growth factor beta 3 accelerates gastric ulcer healing in rats. (9361170)
1997
40
Expression of vascular endothelial growth factor at the human gastric ulcer margin and in cultured gastric fibroblasts: a new angiogenic factor for gastric ulcer healing. (9177300)
1997
41
Focal lesion of African histoplasmosis presenting as a malignant gastric ulcer. (8799429)
1996
42
Cellular and molecular mechanisms of gastric ulcer healing. Is the quality of mucosal scar affected by treatment? (8578218)
1995
43
A new variant case of muscle phosphofructokinase deficiency, coexisting with gastric ulcer, gouty arthritis, and increased hemolysis. (7603526)
1995
44
Gastric ulcer treatment with intravenous human epidermal growth factor: a double-blind controlled clinical study. (7881024)
1994
45
Prostaglandins: viable therapy in gastric ulceration. (8441926)
1993
46
Healthy controls have as much bile reflux as gastric ulcer patients. (3428684)
1987
47
Gastric ulcer and duodenogastric reflux: causal or casual relationship? (6845782)
1983
48
Bile reflux in active and healed gastric ulcer. (5482297)
1970
49
Pneumatosis cystoides intestinalis and large gastric ulcer; report of case. (13667938)
1959
50
Masked perforation of a gastric ulcer in a case of tabes dorsalis. (13094011)
1953

Variations for Gastric Ulcer

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Expression for genes affiliated with Gastric Ulcer

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Search GEO for disease gene expression data for Gastric Ulcer.

Pathways for genes affiliated with Gastric Ulcer

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Compounds for genes affiliated with Gastric Ulcer

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Compounds related to Gastric Ulcer according to GeneCards Suite gene sharing:

(show top 50)    (show all 139)
idCompoundScoreTop Affiliating Genes
14-hydroxydiclofenac439.8PTGS1, CYP2C19
2lansoprazole43 49 24 1212.7CYP2C19, HRH2, NUDT6
3diphenhydramine43 28 2 24 1213.6HRH2, PTGS1, CYP2C19
4ns 39843 5910.5PTGS1, PTGER2, FGF2
55-methylthioadenosine439.5NUDT6, FGF2, ODC1
6famotidine43 2 24 1212.5NUDT6, CYP2C19, HRH2
7omeprazole43 49 28 24 1213.3HRH2, CCKBR, CYP2C19
8diclofenac43 28 49 1212.3PTGS1, CYP2C19, HRH2
9amphetamine43 49 1211.3CCKBR, NUDT6, FGF2
10glucosamine43 24 1211.2CYP2C19, PTGS1, FGF2
11ibmx43 59 2811.1PTGER2, FGF2, ODC1, TFF1
12warfarin43 49 24 1211.9CYP2C19, HRH2, FGF2
13diazepam43 28 49 1211.9FGF2, CYP2C19, PTGS1, CCKBR
14acetaminophen43 2 49 24 1212.8HRH2, PTGS1, HGF, CYP2C19
15prostacyclin438.8PTGS1, HGF, FGF2, PTGER2
16hyaluronic acid43 249.7HGF, FGF2, TFF1, PTGS1
17prostaglandin438.7CCKBR, HRH2, ODC1, PTGS1, PTGER2
18thalidomide43 49 59 1211.7FGF2, CYP2C19, HGF, PTGS1
19herbimycin a43 599.6FGF2, PTGS1, HGF, ODC1
20matrigel438.6NUDT6, FGF2, HGF, ODC1
21ethanol43 49 24 1211.5CYP2C19, TFF1, HRH2, HGF
22lactate438.4HGF, ODC1, HRH2, PTGS1, NUDT6
23indomethacin43 28 59 1211.4CYP2C19, PTGS1, TFF1, PTGER2, HGF
24arachidonic acid43 28 24 1211.4CYP2C19, TFF1, HGF, PTGER2, PTGS1
25agar438.4FGF2, HGF, NUDT6, PTGS1, ODC1
26actinomycin d438.3FGF2, TFF1, ODC1, HGF, PTGS1
27paraffin438.3ODC1, PTGS1, TFF1, HGF, FGF2
28histamine43 28 2410.3HGF, PTGER2, ODC1, HRH2, CCKBR
29genistein43 28 59 2 24 1213.3HGF, FGF2, ODC1, PTGS1, TFF1
30estradiol43 24 1210.2TFF1, CYP2C19, NUDT6, CCKBR, HGF
31cycloheximide438.2TFF1, HGF, ODC1, FGF2, PTGS1
32adenylate438.2ODC1, HRH2, HGF, CCKBR, PTGER2
33testosterone43 59 24 1211.2ODC1, HGF, TFF1, NUDT6, CYP2C19
34sb 20358043 599.2ODC1, CCKBR, HGF, FGF2
35h2o2438.2FGF2, HGF, TFF1, PTGS1, ODC1
36vegf438.2PTGER2, NUDT6, PTGS1, HGF, FGF2, TFF1
37aspirin43 49 28 2411.1PTGER2, PTGS1, ODC1, TFF1, HRH2, HGF
38bromodeoxyuridine438.1FGF2, HGF, ODC1, NUDT6, PTGER2, TFF1
39pge2438.1ODC1, FGF2, HRH2, HGF, PTGS1, PTGER2
40dexamethasone43 49 28 1211.0TFF1, CYP2C19, PTGER2, HGF, FGF2, PTGS1
41nitric oxide43 24 129.9PTGS1, CYP2C19, HRH2, ODC1, CCKBR, NUDT6
42glutamate437.8PTGER2, NUDT6, ODC1, CCKBR, HGF, PTGS1
43arginine437.8ODC1, TFF1, NUDT6, HGF, CCKBR
44phosphatidylinositol437.8CCKBR, HGF, FGF2, PTGER2, NUDT6
45estrogen437.7PTGS1, FGF2, HGF, CYP2C19, ODC1, TFF1
46retinoic acid43 248.6FGF2, NUDT6, HRH2, TFF1, HGF, ODC1
47thymidine43 248.5TFF1, CCKBR, FGF2, NUDT6, ODC1, HGF
48nmda43 288.4HGF, FGF2, CCKBR, ODC1, PTGS1, PTGER2
49tyrosine437.2CYP2C19, NUDT6, FGF2, HGF, CCKBR, ODC1
50serine437.1PTGER2, FGF2, HRH2, HGF, CCKBR, PTGS1

GO Terms for genes affiliated with Gastric Ulcer

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Biological processes related to Gastric Ulcer according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1gland developmentGO:00487329.7HRH2, CCKBR
2digestive tract developmentGO:00485659.6HRH2, CCKBR
3arachidonic acid metabolic processGO:00193699.4CYP2C19, PTGS1
4positive chemotaxisGO:00509189.2FGF2, HGF
5positive regulation of osteoblast differentiationGO:00456699.2FGF2, HGF
6digestionGO:00075869.2CCKBR, TFF1

Molecular functions related to Gastric Ulcer according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chemoattractant activityGO:00420569.2FGF2, HGF
2growth factor activityGO:00080838.2FGF2, HGF, NUDT6, TFF1

Products for genes affiliated with Gastric Ulcer

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Sources for Gastric Ulcer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet