MCID: GST023
MIFTS: 67

Gastric Ulcer malady

Gastrointestinal, Ear categories

Summaries for Gastric Ulcer

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 A peptic ulcer, stomach ulcer or gastric ulcer, also known as peptic ulcer disease (PUD), is a distinct... more...

MalaCards: Gastric Ulcer, also known as chronic gastric ulcer without hemorrhage and without perforation but with obstruction, is related to duodenal ulcer and bile reflux. An important gene associated with Gastric Ulcer is HRH2 (histamine receptor H2), and among its related pathways are p70S6K Signaling and NF-KappaB Family Pathway. The drugs aluminum hydroxide and aluminum hydroxide gel and the compounds pge2 and bromodeoxyuridine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, lymph node and spleen, and related mouse phenotypes are digestive/alimentary and homeostasis/metabolism.

Aliases & Classifications for Gastric Ulcer

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt, 27ICD9CM, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal, Ear


Aliases & Descriptions:

gastric ulcer 8 45 61
chronic gastric ulcer without hemorrhage and without perforation but with obstruction 8
acute gastric ulcer without hemorrhage, without perforation and without obstruction 8
acute gastric ulcer with hemorrhage and perforation, without mention of obstruction 8
acute gastric ulcer with hemorrhage and with perforation but without obstruction 8
acute gastric ulcer with hemorrhage, with perforation and with obstruction 8
acute gastric ulcer with hemorrhage and perforation, with obstruction 8
chronic gastric ulcer without hemorrhage and without perforation 8
acute gastric ulcer without hemorrhage and without perforation 8
acute gastric ulcer with perforation, with obstruction 8
acute gastric ulcer with hemorrhage, with obstruction 8
acute gastric ulcer with perforation and obstruction 8
acute gastric ulcer with haemorrhage and perforation 8
acute gastric ulcer with hemorrhage and obstruction 8
acute gastric ulcer with hemorrhage and perforation 8
chronic gastric ulcer without mention of hemorrhage 8
acute gastric ulcer without mention of hemorrhage 8
perforation, without mention of obstruction 8
acute gastric ulcer with perforation 8
perforation, with obstruction 8
bleeding acute gastric ulcer 8


Related Diseases for Gastric Ulcer

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Gastric Ulcer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 172)
idRelated DiseaseScoreTop Affiliating Genes
1duodenal ulcer30.9GAST, S100A8, HRH2
2bile reflux30.7TFF1
3atrophic gastritis30.6ODC1, TFF2, TFF1, GAST, S100A8
4arthritis30.3PTGS1, HRH2, FGF2, SRF, EPRS, PTGS2
5duodenitis30.2GAST, S100A8
6gastroesophageal reflux disease30.2S100A8, PTGS1, HRH2, GAST
7acute pancreatitis30.1HRH2
8adenoma30.1ODC1, S100A8, GAST, GSR, PTGS2, PTGER2
9adenocarcinoma30.1ODC1, PTGS1, PTGER2, SRF, NUDT6, MUC5AC
10hepatitis c30.1GSR
11gastroduodenitis29.9GAST
12dyspepsia29.9GAST, HRH2
13stomach cancer29.9GAST
14hepatitis b29.9GSR
15rheumatic disease29.9SRF, PTGS2, PTGS1
16h. pylori infection10.6
17duodenogastric reflux10.5
18splenic abscess10.2
19pernicious anemia10.2
20anisakiasis10.1
21gastric dilatation10.1
22tabes dorsalis10.1
23gastric lymphoma10.1
24bacterial gastritis10.1
25gastrojejunal ulcer10.1
26adult syndrome10.1
27scrub typhus10.1
28typhus10.1
29autoimmune pancreatitis10.1
30esophagitis10.0HRH2, GAST, S100A8
31gastroenteritis10.0TFF3
32cystic fibrosis10.0MUC5AC, S100A8
33pneumonia10.0PTGS1, HRH2, S100A8
34cholesteatoma10.0S100A8
35peptic ulcer10.0S100A8, GAST, MUC5AC, PTGS2, PTGS1, HRH2
36endometrial carcinoma10.0PTGER2, MUC5AC, EGF, TFF1
37hepatitis10.0HGF, HRH2
38primary hyperoxaluria10.0PTGS2
39stomach disease10.0PTGS2, PTGS1, HRH2
40rheumatoid arthritis10.0SRF, EPRS, PTGS2, PTGS1, S100A8
41esophageal cancer10.0PTGS2
42meningioma10.0ODC1, TFF1, EGF, CCKBR
43endometriosis10.0HGF, SRF, PTGS2
44obesity10.0CCKBR
45ischemia10.0HGF, EPRS, FGF2, NUDT6, HRH2, GSR
46gastric adenocarcinoma10.0S100A8, GAST, CCKBR, ODC1, PTGS2, HRH2
47osteoarthritis10.0PTGS1, FGF2, S100A8, GSR, PTGS2
48thyroid cancer10.0EGF, CCKBR
49cholangiocarcinoma10.0PTGS2, MUC5AC, TFF1, HGF, CCKBR
50short bowel syndrome10.0GAST, HGF, EGF

Graphical network of the top 20 diseases related to Gastric Ulcer:



Diseases related to gastric ulcer

Clinical Features for Gastric Ulcer

Drugs & Therapeutics for Gastric Ulcer

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Genetic Tests for Gastric Ulcer

Anatomical Context for Gastric Ulcer

Sources:
33MalaCards
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MalaCards organs/tissues related to Gastric Ulcer:

33
Bone marrow, Lymph node, Spleen, Brain, Heart, Small intestine, Colon, Liver, Lung, Pancreas, Thyroid, Salivary gland, Adrenal gland, Breast, Skin, Myeloid, Monocytes, T cells, B cells, Endothelial, Fetal brain, Parietal lobe, Temporal lobe, Tongue, Fetal liver, Fetal lung, Fetal thyroid, Pancreatic islet

Animal Models for Gastric Ulcer or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Gastric Ulcer

Sources:
51PubMed
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Articles related to Gastric Ulcer:

(show top 50)    (show all 962)
idTitleAuthorsYear
1
Atypical gastric ulcer in an elderly cocaine user. (23984119)
2013
2
Attenuation of acetic acid-induced gastric ulcer formation in rats by glucosylceramide synthase inhibitors. (22918683)
2013
3
The usefulness of ulcer size and location in the differential diagnosis of benign and malignant gastric ulcer. (23292642)
2013
4
A study on the protective activity of kefir against gastric ulcer. (22965503)
2012
5
The gender difference of selective serotonin reuptake inhibitor, fluoxetine in adult rats with stress-induced gastric ulcer. (22546225)
2012
6
Bidirectional crosstalk between stress-induced gastric ulcer and depression under chronic stress. (23251441)
2012
7
Increased numbers of Foxp3-positive regulatory T cells in gastritis, peptic ulcer and gastric adenocarcinoma. (22228968)
2012
8
Effects of Morinda citrifolia aqueous fruit extract and its biomarker scopoletin on reflux esophagitis and gastric ulcer in rats. (21163341)
2011
9
Gastric ulcer revealed by computed tomography in a patient with tongue cancer after percutaneous gastrostomy. (21512620)
2011
10
Bleeding gastric ulcer after prophylactic coiling of transarterial chemoembolization. (20453659)
2010
11
Caspase-4 activation in association with decreased adenosine deaminase activity may be a factor for gastric ulcer. (20029210)
2010
12
Education and imaging. Gastrointestinal: Scrub typhus induced acute gastric ulceration. (20594266)
2010
13
Treatment of gastric candidiasis in patients with gastric ulcer disease: are antifungal agents necessary? (20479898)
2009
14
Characterization of mechanisms underlying the effects of esomeprazole on the impairment of gastric ulcer healing with addition of NSAID treatment. (19251492)
2009
15
Association of Helicobacter pylori and Epstein-Barr virus with gastric cancer and peptic ulcer disease. (18569983)
2008
16
The gastric ulcer protective effect of boswellic acids, a leukotriene inhibitor from Boswellia serrata, in rats. (18424019)
2008
17
Equine gastric ulcer syndrome in adult horses: a review. (17339910)
2007
18
F-18 fluorodeoxyglucose uptake in a benign gastric ulcer. (17515755)
2007
19
A case of successful embolotherapy for gastric ulcer bleeding from the intercostal artery after oesophagectomy and gastric reconstruction. (16940369)
2006
20
Development of a novel method to detect Helicobacter pylori cagA genotype from paraffin-embedded materials: comparison between patients with duodenal ulcer and gastric cancer in young Japanese. (16543737)
2006
21
Roles of platelets and proteinase-activated receptors in gastric ulcer healing. (16184414)
2005
22
Effects of antisecretory agents on angiogenesis during healing of gastric ulcers. (16082584)
2005
23
Parietal cell density during gastric ulcer healing in the rat. (14992557)
2004
24
Anisakis in a biopsy specimen from the edge of a gastric ulcer: report of a case. (15557978)
2004
25
Helicobacter pylori down-regulates the receptors of vascular endothelial growth factor and angiopoietin in vascular endothelial cells: implications in the impairment of gastric ulcer healing. (15259499)
2004
26
The influence of cholecystokinin on gastric myoelectrical activity in duodenal ulcer following Helicobacter pylori eradication--an electrogastrographic study. (12120894)
2002
27
Regression of duodenal gastric metaplasia in Helicobacter pylori positive patients with duodenal ulcer disease. (11926569)
2002
28
Phosphorylation of Helicobacter pylori CagA in patients with gastric ulcer and gastritis. (12069371)
2002
29
No protective role of Helicobacter pylori in the pathogenesis of reflux esophagitis in patients with duodenal or benign gastric ulcer in Korea. (11768266)
2001
30
Luminal Nalpha-methyl histamine stimulates gastric acid secretion in duodenal ulcer patients via releasing gastrin. (11165229)
2001
31
A rare gastric ulcer complication: the gastrocolic fistula. A case report. (11824065)
2001
32
Is cytochrome P450 2C9 genotype associated with NSAID gastric ulceration? (11422024)
2001
33
Bacterial colonization and healing of gastric ulcers: the effects of epidermal growth factor. (10644568)
2000
34
Acid secretory response in the late follow-up of proximal gastric vagotomy for duodenal ulcer without Helicobacter pylori eradication. (10228800)
1999
35
Gastric ulcers in SCID mice induced by Helicobacter pylori infection after transplanting lymphocytes from patients with gastric lymphoma. (10500072)
1999
36
Gastric outlet obstruction caused by microperforation of Helicobacter pylori-related antral ulcer. (9563927)
1998
37
Association between genetic polymorphism of the pepsinogen C gene and gastric body ulcer: the genetic predisposition is not associated with Helicobacter pylori infection. (9391244)
1997
38
Gastric corpus IL-8 concentration and neutrophil infiltration in duodenal ulcer patients. (9305491)
1997
39
The level of gastrin, insulin and glucagon in the blood and the morphometric characteristics of the gastric mucosa in peptic ulcer patients of different ages]. (9138823)
1996
40
Gastric mucosal cell proliferation and TGF alpha in the healing of peptic ulcers in human subjects. (8774987)
1995
41
A new variant case of muscle phosphofructokinase deficiency, coexisting with gastric ulcer, gouty arthritis, and increased hemolysis. (7603526)
1995
42
A global study of gastric secretion in duodenal ulcers: gastrin, pepsinogen and acid secretion]. (7662416)
1995
43
Basic fibroblast growth factor treatment for non-steroidal anti-inflammatory drug associated gastric ulceration. (8549933)
1995
44
Gastric ulcer treatment with intravenous human epidermal growth factor: a double-blind controlled clinical study. (7881024)
1994
45
The effect of low temperature on the enzyme activities and the level of SH groups in benign gastric ulcer and gastric carcinoma. (7932052)
1994
46
Regulation of gastric acid secretion by gastrin in duodenal ulcer patients and healthy subjects. (1551523)
1992
47
Quality of gastric ulcer healing: a new, emerging concept. (1719066)
1991
48
Gastritis, duodenogastric reflux and bacteriology of the gastric remnant in patients operated for peptic ulcer by Billroth I operation. (4015029)
1985
49
Duodenogastric reflux in patients with gastric ulcer disease. (6690637)
1984
50
DUODENAL AND GASTRIC ULCERS IN SYSTEMIC SCLERODERMA. (14277903)
1965

Genetic Variations for Gastric Ulcer

Expression for genes affiliated with Gastric Ulcer

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gastric Ulcer

Search GEO for disease gene expression data for Gastric Ulcer.

Pathways for genes affiliated with Gastric Ulcer

Sources:
52QIAGEN, 50PharmGKB, 38NCBI BioSystems Database, 12EMD Millipore, 54Reactome, 30KEGG
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Compounds for genes affiliated with Gastric Ulcer

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 24HMDB, 60Tocris Bioscience, 11DrugBank, 2BitterDB
See all sources

Compounds related to Gastric Ulcer according to GeneCards/GeneDecks:

(show top 50)    (show all 198)
idCompoundScoreTop Affiliating Genes
1pge24510.9PTGS2
2bromodeoxyuridine4510.9FGF2, NUDT6, EGF, TFF1, PTGER2, GAST
3aspirin45 50 29 2413.9HRH2, TFF3, TFF2, TFF1, PTGER2, ODC1
4nmda45 2911.8FGF2, GSR, PTGER2, PTGS1, SRF, EPRS
5glutamate4510.8GAST, CCKBR, EPRS, SRF
6indomethacin45 60 29 1113.8PTGS2, TFF2, PTGS1, TFF3, GSR, PTGER2
7thymidine45 2411.8ODC1, HGF, GAST, CCKBR, TFF1, SRF
8prostaglandin4510.8PTGER2, PTGS1, MUC5AC, HRH2, ODC1, CCKBR
9sucralfate45 1111.8HRH2, FGF2, EGF, GAST
10dexamethasone45 50 29 1113.8TFF1, S100A8, MUC5AC, HGF, PTGER2, PTGS2
11agar4510.8EGF, PTGS1, SRF, NUDT6, S100A8, HGF
12serine4510.8PTGS1, HRH2, EPRS, FGF2, CCKBR, S100A8
13misoprostol45 1111.8GAST, PTGER2, HRH2, PTGS2
14genistein45 29 60 2 11 2415.8HGF, GSR, PTGS2, ODC1, SRF, FGF2
15vegf4510.8HGF, GAST, TFF1, NUDT6, SRF, PTGS1
16actinomycin d4510.8TFF1, FGF2, ODC1, TFF3, PTGS1, PTGS2
17sb 20358045 6011.8MUC5AC, PTGS2, EGF, CCKBR, HGF, ODC1
18histamine45 29 2412.8ODC1, HRH2, MUC5AC, GAST, S100A8, CCKBR
19arachidonic acid45 29 11 2413.8HGF, S100A8, TFF1, TFF2, PTGS2, PTGER2
20cycloheximide4510.8HGF, TFF1
21nitric oxide45 11 2412.8ODC1, CCKBR, S100A8, TFF3, PTGS2, SRF
22nicotinamide45 1111.8EPRS, GSR, HRH2, GAST, HGF
23herbimycin a45 6011.8PTGS1, ODC1, PTGS2, HGF, EGF, FGF2
24h2o24510.8HGF, ODC1, TFF1, TFF3, EGF, EPRS
25paraffin4510.8PTGS1, ODC1, HGF, S100A8, TFF1, TFF3
26acetaminophen45 2 50 11 2414.8HRH2
27methotrexate45 50 1112.8ODC1, SRF, S100A8, HGF, GSR, MUC5AC
28retinoic acid45 2411.8FGF2, TFF1, HRH2, NUDT6, MUC5AC, EGF
29celecoxib45 60 29 50 11 2415.8GAST, FGF2, PTGS2, HRH2, PTGS1
30adenylate4510.8ODC1, HGF, CCKBR, GAST, HRH2, EGF
31phosphatidylinositol4510.8MUC5AC, SRF, FGF2, HGF, CCKBR, EGF
32tyrosine4510.7CCKBR, PTGER2, SRF, EPRS, HGF, S100A8
33pd 98,0594510.7EGF, TFF3, MUC5AC, NUDT6, FGF2, PTGS2
34ag 14784510.7PTGS2, GAST, EGF, MUC5AC, HGF
35calcium45 50 11 2413.7EGF, MUC5AC, EPRS, HRH2, PTGER2, SRF
36thromboxane a245 2411.7PTGS1, PTGER2, PTGS2, EPRS, TFF3
37thalidomide45 50 60 1113.7FGF2, S100A8, HGF, PTGS2, PTGS1
38oxygen45 2411.7PTGS1, S100A8, HGF, HRH2
39testosterone45 60 11 2413.7EGF, HGF, ODC1, NUDT6, SRF, GAST
40k252a4510.7EGF, FGF2, SRF, HGF
41suramin45 29 1112.6NUDT6, SRF
42cysteine4510.6TFF3, ODC1, S100A8, GSR, PTGS1, TFF1
43retinoid4510.6SRF, MUC5AC, TFF1, S100A8, HGF, ODC1
44matrigel4510.6ODC1, EGF, NUDT6
45lactate4510.6ODC1, SRF, HGF, NUDT6, HRH2, PTGS1
46ornithine45 2411.5GAST, CCKBR, HGF, ODC1, SRF
47resveratrol45 60 11 2413.4PTGS1, TFF1, GAST, ODC1
48omeprazole45 29 50 11 2414.4HRH2, GAST, S100A8, CCKBR
49n acetylcysteine4510.3ODC1, HGF, EPRS, MUC5AC, GSR, PTGS2
50gf 109203x45 6011.1EGF, FGF2, PTGER2, PTGS2, GAST

GO Terms for genes affiliated with Gastric Ulcer

Sources:
16Gene Ontology
See all sources

Cellular components related to Gastric Ulcer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.4FGF2, EGF, TFF2, TFF1, S100A8, HGF

Biological processes related to Gastric Ulcer according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cerebellar granule cell precursor proliferationGO:02194010.6EGF, FGF2
2digestionGO:00758610.6MUC5AC, TFF3, TFF2, TFF1, CCKBR
3gland developmentGO:04873210.6HRH2, CCKBR
4positive regulation of cell proliferationGO:00828410.5ODC1, CCKBR, TFF2, EGF, FGF2
5cyclooxygenase pathwayGO:01937110.5PTGS2, PTGS1
6prostaglandin biosynthetic processGO:00151610.5PTGS1, PTGS2
7positive regulation of smooth muscle contractionGO:04598710.4PTGS2, SRF
8cell migration involved in sprouting angiogenesisGO:00204210.2FGF2, SRF

Molecular functions related to Gastric Ulcer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1prostaglandin-endoperoxide synthase activityGO:00466610.5PTGS2, PTGS1
2growth factor activityGO:00808310.2FGF2, NUDT6, EGF, TFF1, HGF

Products for genes affiliated with Gastric Ulcer

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gastric Ulcer

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet