MCID: GST023
MIFTS: 72

Gastric Ulcer malady

Gastrointestinal diseases, Ear diseases categories

Summaries for Gastric Ulcer

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63Wikipedia, 32MalaCards
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Wikipedia:63 A peptic ulcer, stomach ulcer or gastric ulcer, also known as peptic ulcer disease (PUD), is a distinct... more...

MalaCards: Gastric Ulcer, also known as chronic gastric ulcer without hemorrhage and without perforation but with obstruction, is related to gastritis and duodenal ulcer. An important gene associated with Gastric Ulcer is HRH2 (histamine receptor H2), and among its related pathways are p70S6K Signaling and NF-KappaB Family Pathway. The drugs aluminum hydroxide and aluminum hydroxide gel and the compounds pge2 and bromodeoxyuridine have been mentioned in the context of this disorder. Affiliated tissues include endothelial, pancreas and testes, and related mouse phenotypes are digestive/alimentary and homeostasis/metabolism.

Aliases & Classifications for Gastric Ulcer

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Ear diseases


Aliases & Descriptions:

gastric ulcer 8 44 60
chronic gastric ulcer without hemorrhage and without perforation but with obstruction 8
acute gastric ulcer without hemorrhage, without perforation and without obstruction 8
acute gastric ulcer with hemorrhage and perforation, without mention of obstruction 8
acute gastric ulcer with hemorrhage and with perforation but without obstruction 8
acute gastric ulcer with hemorrhage, with perforation and with obstruction 8
acute gastric ulcer with hemorrhage and perforation, with obstruction 8
chronic gastric ulcer without hemorrhage and without perforation 8
acute gastric ulcer without hemorrhage and without perforation 8
acute gastric ulcer with perforation, with obstruction 8
acute gastric ulcer with hemorrhage, with obstruction 8
acute gastric ulcer with perforation and obstruction 8
acute gastric ulcer with haemorrhage and perforation 8
acute gastric ulcer with hemorrhage and obstruction 8
acute gastric ulcer with hemorrhage and perforation 8
chronic gastric ulcer without mention of hemorrhage 8
acute gastric ulcer without mention of hemorrhage 8
perforation, without mention of obstruction 8
acute gastric ulcer with perforation 8
perforation, with obstruction 8
bleeding acute gastric ulcer 8


Related Diseases for Gastric Ulcer

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17GeneCards, 18GeneDecks
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Diseases related to Gastric Ulcer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 181)
idRelated DiseaseScoreTop Affiliating Genes
1gastritis31.0S100A8, GAST, TFF1, TFF2, MUC5AC, HRH2
2duodenal ulcer30.9S100A8, GAST, HRH2
3duodenitis30.9S100A8, GAST
4esophagitis30.7S100A8, GAST, HRH2
5bile reflux30.6TFF1
6atrophic gastritis30.5ODC1, S100A8, GAST, TFF1, TFF2
7hepatocellular carcinoma30.3HGF, CCKBR, S100A8, TFF3, MUC5AC, EPRS
8peptic ulcer30.2S100A8, GAST, MUC5AC, HRH2, PTGS1, PTGS2
9hepatitis30.2HRH2, HGF
10arthritis30.2S100A8, EPRS, FGF2, HRH2, SRF, PTGS1
11gastroenteritis30.1TFF3
12gastroesophageal reflux disease30.1S100A8, GAST, HRH2, PTGS1
13ischemia30.1HGF, NUDT6, EPRS, FGF2, HRH2, GSR
14gastric adenocarcinoma30.1ODC1, HGF, CCKBR, S100A8, GAST, TFF1
15acute pancreatitis30.1HRH2
16adenoma30.1GSR, PTGS2, PTGER2, ODC1, S100A8, GAST
17adenocarcinoma30.1EGF, MUC5AC, NUDT6, SRF, PTGS1, PTGER2
18gastroduodenitis29.9GAST
19dyspepsia29.9HRH2, GAST
20stomach cancer29.9GAST
21pneumonia29.9S100A8, HRH2, PTGS1
22esophageal cancer29.9PTGS2
23melanoma29.9ODC1, HGF, NUDT6, EPRS, FGF2, HRH2
24leukemia29.9ODC1, CCKBR, S100A8, EGF, NUDT6, FGF2
25lung cancer29.9ODC1, HGF, TFF1, EGF, MUC5AC, PTGER2
26diabetes mellitus29.9GSR
27dermatomyositis29.9S100A8
28breast cancer29.9ODC1, TFF1, EGF, PTGS2
29hyperparathyroidism29.9GAST
30duodenogastric reflux10.5
31pancreatitis10.4
32hiatus hernia10.3
33splenic abscess10.2
34pernicious anemia10.2
35hypertension10.2
36anisakiasis10.1
37gastric dilatation10.1
38tabes dorsalis10.1
39gastric lymphoma10.1
40portal hypertension10.1
41bacterial gastritis10.1
42gastrojejunal ulcer10.1
43adult syndrome10.1
44scrub typhus10.1
45hepatitis a10.1
46pyloric stenosis10.1
47typhus10.1
48cystic fibrosis10.0S100A8, MUC5AC
49cholesteatoma10.0S100A8
50endometrial carcinoma10.0PTGER2, MUC5AC, EGF, TFF1

Graphical network of the top 20 diseases related to Gastric Ulcer:



Diseases related to gastric ulcer

Clinical Features for Gastric Ulcer

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Drugs & Therapeutics for Gastric Ulcer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Gastric Ulcer

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Anatomical Context for Gastric Ulcer

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32MalaCards
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MalaCards organs/tissues related to Gastric Ulcer:

32
Endothelial, Pancreas, Testes, Colon, Liver, T cells, Heart, Bone marrow, Lung, Bone, Brain, Lymph node, Monocytes, Myeloid, Spleen, Skin, Breast, Thyroid, Tongue

Animal Models for Gastric Ulcer or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Gastric Ulcer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538110.5HRH2, CCKBR, GAST, TFF1, TFF2, TFF3
2MP:000537610.4PTGER2, CCKBR, GAST, TFF2, MUC5AC, TFF3
3MP:000537910.4EGF, TFF2, CCKBR, PTGS1, GAST
4MP:000538710.4CCKBR, GAST, TFF2, TFF3, EGF, MUC5AC
5MP:000200610.4TFF1, GAST
6MP:000538510.1GSR, PTGS2, PTGER2, PTGS1, FGF2, SRF

Publications for Gastric Ulcer

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50PubMed
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Articles related to Gastric Ulcer:

(show top 50)    (show all 959)
idTitleAuthorsYear
1
Healing effects of Musa sapientum var. paradisiaca in diabetic rats with co-occurring gastric ulcer: cytokines and growth factor by PCR amplification. (24192345)
2013
2
Hyptis suaveolens (L.) Poit (Lamiaceae), a medicinal plant protects the stomach against several gastric ulcer models. (24184082)
2013
3
The probiotic mixture VSL#3 accelerates gastric ulcer healing by stimulating vascular endothelial growth factor. (23484048)
2013
4
Association of presence/absence and on/off patterns of Helicobacter pylori oipA gene with peptic ulcer disease and gastric cancer risks: a meta-analysis. (24256489)
2013
5
Kissing gastric ulcers causing acute pancreatitis and portal biliopathy: what's the link? (24216552)
2013
6
Severe erosive esophagitis developing after gastric ulcer formation. (23024739)
2012
7
Evaluation of anti-ulcer effect of amlodipine in gastric ulcer models in rats. (22701252)
2012
8
Immunomodulatory effect of candesartan on indomethacin-induced gastric ulcer in rats. (22889052)
2012
9
Pharmacokinetic interaction between I/-acetamidocaproic acid (AACA) and cimetidine in indomethacin-induced acute gastric ulcer and control rats: inhibition of active renal secretion of AACA by cimetidine. (21250786)
2011
10
Healing effects of rebamipide and omeprazole in Helicobacter pylori-positive gastric ulcer patients after eradication therapy: a randomized double-blind, multinational, multi-institutional comparative study. (21757914)
2011
11
Stimulation of gastric ulcer healing by heat shock protein 70. (21736872)
2011
12
Enhancement of gastric ulcer healing and angiogenesis by cochinchina Momordica seed extract in rats. (20514308)
2010
13
Gastric acid inhibition in the treatment of peptic ulcer hemorrhage. (19903422)
2009
14
Frequency of Helicobacter pylori vacA genotypes in Iranian patients with gastric and duodenal ulcer. (20701884)
2009
15
Effect of rebamipide on gastric ulcer healing caused by Helicobacter pylori and/or NSAIDs or non NSAIDs-non H. pylori. (19772181)
2009
16
Gastric anisakiasis associated with bleeding gastric ulcer. (18787284)
2008
17
Endoscopic analysis of gastric ulcer after one week's treatment with omeprazole and rabeprazole in relation to CYP2C19 genotype. (17934830)
2008
18
Bizarre gastric ulcer related to betel quid use: report of two cases. (18633872)
2008
19
Accelerated Ulcer Healing and Resistance to Ulcer Recurrence with Gastroprotectants in Rat Model of Acetic Acid-induced Gastric Ulcer. (18545642)
2008
20
Influence of aging on gastric ulcer healing activities of the antioxidants alpha-tocopherol and probucol. (18955044)
2008
21
Gastric ulcer treatment: cure of Helicobacter pylori infection without subsequent acid-suppressive therapy: is it effective? (18467903)
2008
22
Effect of esomeprazole triple therapy on eradication rates of Helicobacter pylori, gastric ulcer healing and prevention of relapse in gastric ulcer patients. (18467912)
2008
23
Effect of Mexican tea herb and pilular adina herb on concrescence of gastric mucosa in experimental gastric ulcer rats. (17609913)
2007
24
Effectiveness of implementation of gastric and duodenal ulcer clinical protocol in the Kyrgyz Republic. (17378181)
2007
25
A multicenter, randomized, double-blind, active-comparator, placebo-controlled, parallel-group comparison of the incidence of endoscopic gastric and duodenal ulcer rates with valdecoxib or naproxen in healthy subjects aged 65 to 75 years. (16750449)
2006
26
Curcumin regulates expression and activity of matrix metalloproteinases 9 and 2 during prevention and healing of indomethacin-induced gastric ulcer. (15615723)
2005
27
Changes in the histology and function of gastric mucosa and in Helicobacter pylori colonization during a long-term follow-up period after vagotomy in duodenal ulcer patients. (15966205)
2005
28
Lewis blood genotypes of peptic ulcer and gastric cancer patients in Taiwan. (16097066)
2005
29
Inhibition of breast cancer regrowth and pulmonary metastasis in nude mice by anti-gastric ulcer agent, irsogladine. (14758089)
2004
30
Cholesteryl glucoside-induced protection against gastric ulcer. (12951438)
2003
31
Acceleration of gastric ulcer healing by omeprazole in portal hypertensive rats. Is its action mediated by gastrin release and the stimulation of epithelial proliferation? (12679615)
2003
32
Effect of rebamipide on acetic acid-induced gastric ulcer in rats: involvement of hepatocyte growth factor. (12678329)
2003
33
The influence of feeding on gastric acid suppression in Helicobacter pylori-positive patients treated with a proton pump inhibitor or an H2-receptor antagonist after bleeding from a gastric ulcer. (14564629)
2003
34
The evolving management of gastric outlet obstruction from peptic ulcer disease. (16093176)
2002
35
Pathogenesis and therapy of gastric and duodenal ulcer disease. (12510460)
2002
36
Gastric ulcer as a rare complication of percutaneous ethanol injection for hepatocellular carcinoma. (11922588)
2002
37
Cytomegalovirus-associated gastric ulcer in an immunosuppressed patient with pemphigus vulgaris. (11298108)
2001
38
Higher concentration of matrix-metalloproteinase 1 (interstitial collagenase) in H. pylori-compared to NSAID-induced gastric ulcers. (11132534)
2000
39
A novel method to produce extensive gastric antral ulcer in rats: pharmacological factors involved in the etiology of antral ulceration. (10674922)
1999
40
Short term effect of Salvia miltiorrhiza in treating rat acetic acid chronic gastric ulcer and long term effect in preventing recurrence. (11819266)
1998
41
Impaired fibrinolysis and increased protease levels in gastric and duodenal mucosa of patients with active duodenal ulcer. (9149198)
1997
42
Amebiasis in a dog with gastric ulcers and adenocarcinoma. (9087935)
1997
43
Cholecystokinin in the control of gastric acid secretion and gastrin release in response to a meal at low and high pH in healthy subjects and duodenal ulcer patients. (7481540)
1995
44
Behaviour of acid secretion, gastrin release, serum pepsinogen I, and gastric emptying of liquids over six months from eradication of helicobacter pylori in duodenal ulcer patients. A controlled study. (7557570)
1995
45
Vacuolating cytotoxin production by Helicobacter pylori isolates from peptic ulcer, atrophic gastritis and gastric carcinoma patients. (7735931)
1994
46
Marked gastric mucosal hyperplasia without definite peptic ulceration related to a multifocal hepatic gastrinoma. (7815264)
1994
47
Somatostatin in gastric juice in normal subjects and patients with duodenal ulcer. (1352198)
1992
48
The content of gastrin, bombesin and somatostatin in the blood and gastric juice of patients with duodenal and gastric peptic ulcer]. (1354894)
1992
49
Gastric cancer in chronic atrophic gastritis. Associated gastric ulcer adds no further risk. (3611683)
1987
50
Surgical treatment of gastric, duodenal and gastrojejunal ulcer, including the present status of vagotomy. (18892322)
1948

Genetic Variations for Gastric Ulcer

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Expression for genes affiliated with Gastric Ulcer

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gastric Ulcer

Search GEO for disease gene expression data for Gastric Ulcer.

Pathways for genes affiliated with Gastric Ulcer

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51QIAGEN, 49PharmGKB, 37NCBI BioSystems Database, 12EMD Millipore, 53Reactome, 29KEGG
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Compounds for genes affiliated with Gastric Ulcer

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Sources:
44Novoseek, 49PharmGKB, 28IUPHAR, 24HMDB, 59Tocris Bioscience, 11DrugBank, 2BitterDB
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Compounds related to Gastric Ulcer according to GeneCards/GeneDecks:

(show top 50)    (show all 198)
idCompoundScoreTop Affiliating Genes
1pge24410.9PTGS2
2bromodeoxyuridine4410.9FGF2, NUDT6, EGF, TFF1, PTGER2, GAST
3aspirin44 49 28 2413.9HRH2, TFF3, TFF2, TFF1, PTGER2, ODC1
4nmda44 2811.8FGF2, GSR, PTGER2, PTGS1, SRF, EPRS
5glutamate4410.8GAST, CCKBR, EPRS, SRF
6indomethacin44 59 28 1113.8PTGS2, TFF2, PTGS1, TFF3, GSR, PTGER2
7thymidine44 2411.8ODC1, HGF, GAST, CCKBR, TFF1, SRF
8prostaglandin4410.8PTGER2, PTGS1, MUC5AC, HRH2, ODC1, CCKBR
9sucralfate44 1111.8HRH2, FGF2, EGF, GAST
10dexamethasone44 49 28 1113.8TFF1, S100A8, MUC5AC, HGF, PTGER2, PTGS2
11agar4410.8EGF, PTGS1, SRF, NUDT6, S100A8, HGF
12serine4410.8PTGS1, HRH2, EPRS, FGF2, CCKBR, S100A8
13misoprostol44 1111.8GAST, PTGER2, HRH2, PTGS2
14genistein44 28 59 2 11 2415.8HGF, GSR, PTGS2, ODC1, SRF, FGF2
15vegf4410.8HGF, GAST, TFF1, NUDT6, SRF, PTGS1
16actinomycin d4410.8TFF1, FGF2, ODC1, TFF3, PTGS1, PTGS2
17sb 20358044 5911.8MUC5AC, PTGS2, EGF, CCKBR, HGF, ODC1
18histamine44 28 2412.8ODC1, HRH2, MUC5AC, GAST, S100A8, CCKBR
19arachidonic acid44 28 11 2413.8HGF, S100A8, TFF1, TFF2, PTGS2, PTGER2
20cycloheximide4410.8HGF, TFF1
21nitric oxide44 11 2412.8ODC1, CCKBR, S100A8, TFF3, PTGS2, SRF
22nicotinamide44 1111.8EPRS, GSR, HRH2, GAST, HGF
23herbimycin a44 5911.8PTGS1, ODC1, PTGS2, HGF, EGF, FGF2
24h2o24410.8HGF, ODC1, TFF1, TFF3, EGF, EPRS
25paraffin4410.8PTGS1, ODC1, HGF, S100A8, TFF1, TFF3
26acetaminophen44 2 49 11 2414.8HRH2
27methotrexate44 49 1112.8ODC1, SRF, S100A8, HGF, GSR, MUC5AC
28retinoic acid44 2411.8FGF2, TFF1, HRH2, NUDT6, MUC5AC, EGF
29celecoxib44 59 28 49 11 2415.8GAST, FGF2, PTGS2, HRH2, PTGS1
30adenylate4410.8ODC1, HGF, CCKBR, GAST, HRH2, EGF
31phosphatidylinositol4410.8MUC5AC, SRF, FGF2, HGF, CCKBR, EGF
32tyrosine4410.7CCKBR, PTGER2, SRF, EPRS, HGF, S100A8
33pd 98,0594410.7EGF, TFF3, MUC5AC, NUDT6, FGF2, PTGS2
34ag 14784410.7PTGS2, GAST, EGF, MUC5AC, HGF
35calcium44 49 11 2413.7EGF, MUC5AC, EPRS, HRH2, PTGER2, SRF
36thromboxane a244 2411.7PTGS1, PTGER2, PTGS2, EPRS, TFF3
37thalidomide44 49 59 1113.7FGF2, S100A8, HGF, PTGS2, PTGS1
38oxygen44 2411.7PTGS1, S100A8, HGF, HRH2
39testosterone44 59 11 2413.7EGF, HGF, ODC1, NUDT6, SRF, GAST
40k252a4410.7EGF, FGF2, SRF, HGF
41suramin44 28 1112.6NUDT6, SRF
42cysteine4410.6TFF3, ODC1, S100A8, GSR, PTGS1, TFF1
43retinoid4410.6SRF, MUC5AC, TFF1, S100A8, HGF, ODC1
44matrigel4410.6ODC1, EGF, NUDT6
45lactate4410.6ODC1, SRF, HGF, NUDT6, HRH2, PTGS1
46ornithine44 2411.5GAST, CCKBR, HGF, ODC1, SRF
47resveratrol44 59 11 2413.4PTGS1, TFF1, GAST, ODC1
48omeprazole44 28 49 11 2414.4HRH2, GAST, S100A8, CCKBR
49n acetylcysteine4410.3ODC1, HGF, EPRS, MUC5AC, GSR, PTGS2
50gf 109203x44 5911.1EGF, FGF2, PTGER2, PTGS2, GAST

GO Terms for genes affiliated with Gastric Ulcer

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16Gene Ontology
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Cellular components related to Gastric Ulcer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.4FGF2, EGF, TFF2, TFF1, S100A8, HGF

Biological processes related to Gastric Ulcer according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cerebellar granule cell precursor proliferationGO:02194010.6EGF, FGF2
2digestionGO:00758610.6MUC5AC, TFF3, TFF2, TFF1, CCKBR
3gland developmentGO:04873210.6HRH2, CCKBR
4positive regulation of cell proliferationGO:00828410.5ODC1, CCKBR, TFF2, EGF, FGF2
5cyclooxygenase pathwayGO:01937110.5PTGS2, PTGS1
6prostaglandin biosynthetic processGO:00151610.5PTGS1, PTGS2
7positive regulation of smooth muscle contractionGO:04598710.4PTGS2, SRF
8cell migration involved in sprouting angiogenesisGO:00204210.2FGF2, SRF

Molecular functions related to Gastric Ulcer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1prostaglandin-endoperoxide synthase activityGO:00466610.5PTGS2, PTGS1
2growth factor activityGO:00808310.2FGF2, NUDT6, EGF, TFF1, HGF

Products for genes affiliated with Gastric Ulcer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gastric Ulcer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet