MCID: GST023
MIFTS: 57

Gastric Ulcer

Categories: Gastrointestinal diseases

Aliases & Classifications for Gastric Ulcer

MalaCards integrated aliases for Gastric Ulcer:

Name: Gastric Ulcer 12 51 14 69
Acute Gastric Ulcer Without Mention of Hemorrhage or Perforation, Without Mention of Obstruction 12
Chronic Gastric Ulcer Without Hemorrhage and Without Perforation but with Obstruction 12
Chronic Gastric Ulcer Without Mention of Hemorrhage or Perforation, with Obstruction 12
Acute Gastric Ulcer with Hemorrhage and Perforation, Without Mention of Obstruction 12
Acute Gastric Ulcer Without Hemorrhage, Without Perforation and Without Obstruction 12
Acute Gastric Ulcer with Hemorrhage and with Perforation but Without Obstruction 12
Acute Gastric Ulcer with Hemorrhage, with Perforation and with Obstruction 12
Acute Gastric Ulcer with Hemorrhage and Perforation, with Obstruction 12
Chronic Gastric Ulcer Without Hemorrhage and Without Perforation 12
Acute Gastric Ulcer Without Hemorrhage and Without Perforation 12
Acute Gastric Ulcer with Hemorrhage and Perforation [dup] 12
Acute Gastric Ulcer with Perforation, with Obstruction 12
Acute Gastric Ulcer with Hemorrhage, with Obstruction 12
Acute Gastric Ulcer with Haemorrhage and Perforation 12
Acute Gastric Ulcer with Perforation and Obstruction 12
Acute Gastric Ulcer with Hemorrhage and Obstruction 12
Acute Gastric Ulcer with Hemorrhage and Perforation 12
Acute Gastric Ulcer with Perforation 12
Bleeding Acute Gastric Ulcer 12
Stomach Ulcer 41

Classifications:



Summaries for Gastric Ulcer

MalaCards based summary : Gastric Ulcer, also known as acute gastric ulcer without mention of hemorrhage or perforation, without mention of obstruction, is related to bile reflux and peptic ulcer disease. An important gene associated with Gastric Ulcer is HRH2 (Histamine Receptor H2), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Pathways in cancer. The drugs Amoxicillin and Clarithromycin have been mentioned in the context of this disorder. Affiliated tissues include testes, endothelial and thyroid, and related phenotypes are digestive/alimentary and neoplasm

Related Diseases for Gastric Ulcer

Diseases related to Gastric Ulcer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 183)
# Related Disease Score Top Affiliating Genes
1 bile reflux 30.5 PTGS2 TFF1
2 peptic ulcer disease 30.3 CXCL8 CYP2C19 GAST HRH2 IL1B IL1RN
3 atrophic gastritis 29.8 CXCL8 GAST IL1B IL1RN
4 gastritis 29.8 CXCL8 GAST HRH2 IL1B IL1RN PTGS2
5 arthritis 29.5 CXCL8 IL1B IL1RN PTGS2
6 esophagitis 29.5 CXCL8 CYP2C19 HRH2 IL1B PTGS2
7 helicobacter pylori infection 29.5 CXCL8 CYP2C19 GAST IL1B IL1RN
8 rheumatic disease 29.5 IL1B PTGS1 PTGS2
9 gastric adenocarcinoma 29.1 GAST IL1RN PTGS2 TFF1
10 peptic esophagitis 28.9 CXCL8 CYP2C19 HRH2 IL1B
11 duodenal ulcer 28.9 CXCL8 CYP2C19 GAST HRH2 IL1B IL1RN
12 dyspepsia 28.4 CXCL8 CYP2C19 HRH2 PTGS1 PTGS2
13 gastroesophageal reflux 28.3 CXCL8 CYP2C19 HRH2 IL1B PTGS1 PTGS2
14 gastric cancer 28.2 EGF GAST HGF IL1RN MMP7 PTGS2
15 chronic erosive gastritis 11.1
16 acute generalized exanthematous pustulosis 10.4 CXCL8 PTGS2
17 leukoregulin 10.4 CXCL8 PTGS2
18 recurrent corneal erosion 10.4 CXCL8 IL1B
19 bagassosis 10.4 CXCL8 IL1B
20 vulvar vestibulitis syndrome 10.4 IL1B IL1RN
21 gastric cancer, hereditary diffuse 10.4 IL1B IL1RN
22 schnitzler syndrome 10.4 IL1B IL1RN
23 pancreatic cholera 10.3 GAST HRH2
24 chronic ulcer of skin 10.3 EGF FGF2
25 cerebral artery occlusion 10.3 IL1B IL1RN
26 funisitis 10.3 CXCL8 IL1B
27 aspirin resistance 10.3 PTGS1 PTGS2
28 haemophilus influenzae 10.3 CXCL8 IL1B
29 peptic ulcer perforation 10.3 GAST HRH2 PTGS2
30 pouchitis 10.3 CXCL8 IL1RN
31 burns 10.3 HGF IL1B
32 opisthorchiasis 10.3 CXCL8 IL1B
33 ovarian epithelial cancer 10.3 PTGS1 PTGS2
34 crohn's colitis 10.3 CXCL8 IL1B
35 osteosclerotic myeloma 10.3 IL1B IL1RN
36 laryngitis 10.3 FGF2 HRH2 IL1B
37 chronic myocardial ischemia 10.2 FGF2 HGF
38 dental pulp disease 10.2 CXCL8 IL1B
39 adamantinoma of long bones 10.2 EGF FGF2
40 vaginal disease 10.2 CXCL8 IL1B
41 duodenitis 10.2
42 endometrial disease 10.2 CXCL8 IL1B PTGS2
43 pharyngitis 10.2 CXCL8 IL1B PTGS2
44 vaginitis 10.2 CXCL8 IL1B
45 cystitis 10.2 CXCL8 EGF PTGS2
46 mucositis 10.2
47 perinatal necrotizing enterocolitis 10.2 CXCL8 EGF IL1B
48 endometriosis 10.2 CXCL8 IL1B PTGS2
49 mevalonic aciduria 10.2 IL1B IL1RN
50 active peptic ulcer disease 10.2 HRH2 PTGS1 PTGS2

Graphical network of the top 20 diseases related to Gastric Ulcer:



Diseases related to Gastric Ulcer

Symptoms & Phenotypes for Gastric Ulcer

MGI Mouse Phenotypes related to Gastric Ulcer:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.5 EGF GAST HRH2 MMP7 PTGS1 PTGS2
2 neoplasm MP:0002006 9.17 FGF2 GAST IL1B MMP7 PTGS1 PTGS2

Drugs & Therapeutics for Gastric Ulcer

Drugs for Gastric Ulcer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 139)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3 26787-78-0 33613 2171
2
Clarithromycin Approved Phase 4,Phase 2,Phase 3 81103-11-9 84029
3
Dexlansoprazole Approved, Investigational Phase 4,Phase 3,Phase 1 138530-94-6, 103577-45-3 9578005
4
Lansoprazole Approved, Investigational Phase 4,Phase 3,Phase 1 103577-45-3 3883
5
Metronidazole Approved Phase 4,Phase 2,Phase 3 443-48-1 4173
6
Rabeprazole Approved, Investigational Phase 4,Phase 2,Phase 3 117976-89-3 5029
7
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-78-2 2244
8
Celecoxib Approved, Investigational Phase 4,Phase 3 169590-42-5 2662
9
Esomeprazole Approved, Investigational Phase 4,Phase 3,Phase 1 161796-78-7, 119141-88-7 9579578 4594
10
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22204-53-1 156391 1302
11
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1 73590-58-6 4594
12
Ecabet Approved, Investigational Phase 4 33159-27-2, 86408-72-2 65781
13
Pantoprazole Approved Phase 4,Phase 3 102625-70-7 4679
14
Sulpiride Approved, Investigational Phase 4 15676-16-1 5355
15
Remifentanil Approved Phase 4 132875-61-7 60815
16
Colchicine Approved Phase 4 64-86-8 2833 6167
17
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
18
Famotidine Approved Phase 4,Phase 3 76824-35-6 3325
19
Histamine Approved, Investigational Phase 4,Phase 3,Phase 1 51-45-6, 75614-87-8 774
20
Ranitidine Approved Phase 4,Phase 3 66357-59-3, 66357-35-5 3001055
21 Benzimidazole Experimental, Investigational Phase 4 51-17-2
22 Rebamipide Investigational Phase 4,Phase 3,Phase 2 90098-04-7
23 Antacids Phase 4,Phase 2,Phase 3,Phase 1
24 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3
25 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1
26 Anti-Ulcer Agents Phase 4,Phase 2,Phase 3,Phase 1
27 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 2,Phase 3
28 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 2,Phase 3,Phase 1
29 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1
30 Proton pump inhibitors Phase 4,Phase 2,Phase 3,Phase 1
31 Antiparasitic Agents Phase 4,Phase 2,Phase 3
32 Antiprotozoal Agents Phase 4,Phase 2,Phase 3
33 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
34 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1
35 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
36 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2,Phase 1
37 Antipyretics Phase 4,Phase 3,Phase 2
38 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
39 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
40 Fibrinolytic Agents Phase 4,Phase 3,Phase 2,Phase 1
41 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
42 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
43 Cyclooxygenase 2 Inhibitors Phase 4,Phase 3
44 HIV Protease Inhibitors Phase 4
45
protease inhibitors Phase 4
46 Protective Agents Phase 4,Phase 3,Phase 1
47 Neurotransmitter Agents Phase 4,Phase 3,Phase 1
48 Antioxidants Phase 4,Phase 3
49 Geranylgeranylacetone Phase 4,Phase 2,Phase 3
50 Analgesics, Opioid Phase 4

Interventional clinical trials:

(show top 50) (show all 133)

# Name Status NCT ID Phase Drugs
1 H. Pylori Eradication on Healing of Iatrogenic Gastric Ulcer by Endoscopic Mucosal Resection Unknown status NCT00926809 Phase 4 Lansoprazole (proton pump inhibitor), amoxicillin, clarythromycin;Lansoprazole (proton pump inhibitor), placebo
2 Concomitant Therapy of H. Pylori Unknown status NCT01922765 Phase 4 amoxicillin, clarithromycin, metronidazole, rabeprazole
3 The Safety and Efficacy of Albis®: The Prevention of Aspirin-induced Gastrointestinal Ulcers in Patients Unknown status NCT01397240 Phase 4 Albis Tab;Placebo
4 Gastro-protective Effect and Pain Relief Effect of Naxozol Compared to Celecoxib in Patients With Osteoarthritis Unknown status NCT02355236 Phase 4 Naproxen/Esomeprazol 500/20mg;Celecoxib 200mg;Naxozol-Placebo;Comparator-Placebo
5 Study Comparing Sequential and Concomitant Therapy for Helicobacter Pylori Eradication in Routine Clinical Practice Unknown status NCT01273441 Phase 4 PPI, amoxicillin, metronidazole and clarithromycin;PPI, amoxicillin, metronidazole and clarithromycin
6 14-day Quadruple Hybrid vs. Concomitant Therapies for Helicobacter Pylori Eradication Unknown status NCT01464060 Phase 4 PPI, amoxicillin, metronidazole and clarithromycin;PPI, amoxicillin, metronidazole and clarithromycin
7 Efficacy of Ecabet Sodium and Proton Pump Inhibitor Combination Therapy in the Treatment of Iatrogenic Ulcer After Endoscopic Submucosal Dissection Unknown status NCT01308177 Phase 4 Ecabet
8 Healing Effects of Rebamipide and Omeprazole in Helicobacter Pylori-positive Gastric Ulcer After Eradication Therapy Completed NCT00272467 Phase 4 Rebamipide;Omeprazole
9 Post-Marketing Clinical Study of Rebamipide in Patients With Gastric Ulcer Completed NCT00233389 Phase 4 Rebamipide
10 A Double-blind, Comparative Study in Patients With Gastric Ulcer to Evaluate the Efficacy of Combination Use of E0671 and Rabeprazole Sodium Completed NCT00125736 Phase 4 Teprenone
11 Efficacy and Safety of Teprenone in Patients With Acute Gastritis, Acute Gastric Lesion of Chronic Gastritis With Acute Exacerbation or Gastric Ulcer Completed NCT01190657 Phase 4 Selbex;Selbex
12 An Open-label, Exploratory Trial to Assess Gastric Acid Control in Critically Ill Subjects Receiving Nexium Completed NCT00428701 Phase 4 Esomeprazole Sodium
13 Effect of Prevacid on Prostaglandin Levels in Patient With Stress Ulcer Completed NCT00239551 Phase 4 Prevacid
14 Pharmacogenetics of Gastrointestinal Bleeding Completed NCT00190255 Phase 4
15 Opioid-induced Hyperalgesia After Remifentanil Infusion Completed NCT01702389 Phase 4 Remifentanil
16 Importance of Cytokines in Peptic Ulcer Disease: Implications for Treatment Completed NCT00534443 Phase 4
17 Colchicine Or Naproxen Treatment for ACute gouT Completed NCT01994226 Phase 4 Low-dose colchicine;Naproxen 750 mg/250 mg
18 Treatment of Upper Eyelid Retraction Related to Thyroid-associated Ophthalmopathy Using Subconjunctival Triamcinolone Injections Completed NCT01599273 Phase 4 subconjunctival triamcinolone injection
19 Argon Plasma Coagulation for Bleeding Peptic Ulcers Completed NCT02241044 Phase 4
20 Effect of ALBIS on Gastroduodenal Mucosal Injury in Patients Receiving Dual Antiplatelet Therapy After Percutaneous Coronary Intervention Recruiting NCT02175186 Phase 4 ALBIS;Placebo
21 Helicobacter Eradication Aspirin Trial Active, not recruiting NCT01506986 Phase 4 Lansoprazole 30mg, Clarithromycin 500mg, Metronidazole 400mg;Placebo lansoprazole 30mg, clarithromycin 500mg, metronidazole 400mg
22 Proton Pump Inhibitor Prevent Dual Antiplatelet Agents Induced Gastrointestinal Ulcer After Coronary Artery Bypass Graft Not yet recruiting NCT03038009 Phase 4 Pantoprazole
23 Comparison of Intravenous Pantoprazole and Famotidine for Stress Ulcer Prophylaxis Terminated NCT00839488 Phase 4 pantoprazole 40 mg iv;famotidine 20 mg iv
24 Lansoprazole Preventing Gastroduodenal Stress Ulcerations Terminated NCT00220909 Phase 4 Lansoprazole
25 Treatment of Knee Pain With Topical Diclofenac Cream 8% or Diclofenac Gel 1% Unknown status NCT02068859 Phase 3 Diclofenac Cream 8%;Diclofenac Gel 1%
26 Second Line Therapy for the Cure of Helicobacter Pylori (H. Pylori) Infection Unknown status NCT00197418 Phase 2, Phase 3 rabeprazole, amoxicillin, clarithromycin, metronidazole
27 Tailored Treatment of H. Pylori Infection Based Polymorphisms of CYP2C19 and 23S rRNA of H. Pylori Unknown status NCT00149084 Phase 3 Lansoprazole, clarithromycin, amoxicillin
28 Efficacy of TAK-438 Compared to AG-1749 (Lansoprazole) in the Treatment of Gastric Ulcer Completed NCT01452711 Phase 3 TAK-438;Placebo;Lansoprazole;Placebo
29 Study to Evaluate the Incidence of Gastric Ulcers Following Administration of Either PA32540 or Enteric Coated Aspirin 325 mg in Subjects Who Are at Risk for Developing Aspirin-Associated Ulcers Completed NCT00960869 Phase 3 PA32540;EC-Aspirin 325 mg
30 A Study to Evaluate the Incidence of Gastric Ulcers Following Administration of Either PA32540 or Enteric Coated Aspirin 325 mg in Subjects Who Are at Risk for Developing Aspirin-Associated Ulcers Completed NCT00961350 Phase 3 PA32540;EC Aspirin 325
31 Efficacy and Safety Study of Esomeprazole 20mg qd vs Ranitidine 150mg Bid in Patients With an NSAID-induced Gastric Ulcer Completed NCT00401752 Phase 3 Esomeprazole;Ranitidine
32 Evaluating PN 400 (VIMOVO) in Reducing Gastric Ulcers Compared to Non-steroidal Antiinflammatory Drug (NSAID) Naproxen Completed NCT01129011 Phase 3 PN400 (VIMOVO);Naproxen
33 Healing Effects of Autologous Platelet Rich Plasma on Gastric Ulcer Caused by Endoscopic Submucosal Dissection Completed NCT03220334 Phase 3 Platelet rich plasma;Normal saline
34 Mucosta in Gastric Ulcer Treatment, Effectiveness and Safety Evaluation Completed NCT01150162 Phase 3 Rebamipide and Omeprazole;Omeprazole
35 A Comparative Efficacy and Safety Study of Nexium Delayed-Release Capsules (40mg qd and 20mg qd) Versus Ranitidine 150mg Bid for the Healing of NSAID-Associated Gastric Ulcers When Daily NSAID Use is Continued Completed NCT00633672 Phase 3 Esomeprazole;Ranitidine;Esomeprazole
36 Evaluating PN 400 (VIMOVO) in Reducing Gastric Ulcers Compared to Non-steroidal Antiinflammatory Drug (NSAID) Naproxen Completed NCT00527787 Phase 3 PN400 (VIMOVO);Naproxen
37 Prevention of Gastric Ulcers Completed NCT00629512 Phase 3 Esomeprazole;Esomeprazole;Placebo
38 A Comparative Efficacy and Safety Study of Nexium Delayed-Release Capsules (40mg qd and 20mg qd) Versus Ranitidine 150mg Bid for the Healing of NSAID-Associated Gastric Ulcers When Daily NSAID Use is Continued in Subjects in the US Only Completed NCT00633412 Phase 3 Esomeprazole;Ranitidine;Esomeprazole
39 Rates of Gastric Ulcer by Endoscopy in Knee Osteoarthritis Patients Receiving LT-NS001 Versus Naprosyn® Completed NCT01063920 Phase 2, Phase 3 LT-NS001;Naprosyn®
40 Study to Evaluate the Long-Term Safety of PA32540 in Subjects Who Are at Risk for Developing Aspirin-Associated Gastric Ulcers Completed NCT00995410 Phase 3 PA32540
41 Study to Evaluate the Incidence of Gastric Ulcers Following Administration of Either PN 200 or Naproxen in Subjects Who Are at Risk for Developing NSAID-Associated Ulcers. Completed NCT00367211 Phase 3 PN 200 tablets (500 mg naproxen and 20 mg omeprazole);Naproxen 500 mg tablets (PN 200 minus omeprazole)
42 Ulcer Prevention II Completed NCT00629928 Phase 3 Esomeprazole;Esomeprazole;Placebo
43 Effect of Selective COX-2 Inhibition on Ulcer Healing Completed NCT00153673 Phase 3 celecoxib;Dologesics
44 Efficacy and Safety of Lansoprazole on Gastric and Duodenal Ulcers in Patients Taking Nonsteroidal Anti-Inflammatory Drugs Completed NCT00787254 Phase 3 Lansoprazole;Gefarnate
45 A 12-month, Phase 3, Open-label, Multi-center Study to Evaluate the Long-term Safety of PN400 (VIMOVO) Completed NCT00527904 Phase 3 PN400 (VIMOVO);PN 400 (VIMOVO)
46 Long-term Prevention of Recurrent Gastric or Duodenal Ulcers Caused by Low-dose Aspirin With Rabeprazole (E3810) Treatment (Planetarium Study) Completed NCT01398410 Phase 2, Phase 3 Rabeprazole;Rabeprazole
47 PReventive Efficacy and Safety of rEbamipide on Nsaid Induced Mucosal Toxicity Completed NCT00576706 Phase 3 Rebamipide;Misoprostol
48 Study of Esomeprazole 20 mg or 40 mg vs Placebo Effectiveness on the Occurrence of Peptic Ulcers in Subjects on Low Dose Acetylsalicylic Acid (LDA) Completed NCT00441727 Phase 3 Esomeprazole 40 mg;Esomeprazole 20 mg;Placebo
49 A Unblinded Study of TAK-438 (20 mg) for Prevention of Recurrence of Gastric or Duodenal Ulcer During Long-Term Low-Dose Aspirin Therapy Completed NCT01568398 Phase 3 TAK-438
50 A Unblinded Study of TAK-438 (20 mg) for Prevention of Recurrence of Gastric or Duodenal Ulcer During Long-Term Non-Steroid Anti-Inflammatory Drug (NSAID) Therapy Completed NCT01568385 Phase 3 TAK-438

Search NIH Clinical Center for Gastric Ulcer

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: stomach ulcer

Genetic Tests for Gastric Ulcer

Anatomical Context for Gastric Ulcer

MalaCards organs/tissues related to Gastric Ulcer:

38
Testes, Endothelial, Thyroid, Spinal Cord, Liver, Eye, Heart

Publications for Gastric Ulcer

Articles related to Gastric Ulcer:

(show top 50) (show all 809)
# Title Authors Year
1
Gastric ulcer related with gastrostomy feeding tube: Description of 3 cases and review of literature. ( 29366827 )
2018
2
Protective role of I^-patchoulene from Pogostemon cablin against indomethacin-induced gastric ulcer in rats: Involvement of anti-inflammation and angiogenesis. ( 29433672 )
2018
3
Gastroprotective effect and mode of action of methanol extract of Sphenodesme involucrata var. paniculata (C.B. Clarke) Munir (Lamiaceae) leaves on experimental gastric ulcer models. ( 29136948 )
2018
4
Accelerated gastric ulcer healing in thyroxine-treated rats; roles of gastric acid, mucus and inflammatory response. ( 29406826 )
2018
5
Prophylactic efficacy of patchoulene epoxide against ethanol-induced gastric ulcer in rats: Influence on oxidative stress, inflammation and apoptosis. ( 29339218 )
2018
6
Protective Effect of a Polyherbal Traditional Formula Consisting of<i>Rosa damascena</i>Mill.,<i>Glycyrrhiza glabra</i>L. And<i>Nardostachys jatamansi</i>DC., Against Ethanol-induced Gastric Ulcer. ( 28979324 )
2017
7
Protective Effect of Two Extracts of Cydonia oblonga Miller (Quince) Fruits on Gastric Ulcer Induced by Indomethacin in Rats. ( 28900537 )
2017
8
Structure Features and Anti-Gastric Ulcer Effects of Inulin-Type Fructan CP-A from the Roots of Codonopsis pilosula (Franch.) Nannf. ( 29258255 )
2017
9
Formation of new blood vessels during gastric ulcer healing. Role of bone marrow derived endothelial progenitor cells. ( 29151075 )
2017
10
Perforated gastric ulcer in severe dengue infection: A case report. ( 28889137 )
2017
11
Mean platelet volume, platelet distribution width and carcinoembryonic antigen to discriminate gastric cancer from gastric ulcer. ( 28977972 )
2017
12
Anti-inflammatory effects of nesfatin-1 on acetic acid-induced gastric ulcer in rats: involvement of cyclo-oxygenase pathway. ( 29375052 )
2017
13
Comparison of aloe vera and omeprazole in the treatment of equine gastric ulcer syndrome. ( 28555939 )
2017
14
Mechanistic evaluation of gastroprotective effects of Kangfuxin on ethanol-induced gastric ulcer in mice. ( 28606470 )
2017
15
Surgical Scales: Primary Closure versus Gastric Resection for Perforated Gastric Ulcer - A Surgical Debate. ( 28584503 )
2017
16
Large intramural hematoma and gastric ulcer after EMR of a small gastric polyp. ( 29223380 )
2017
17
Effects of quinine on gastric ulcer healing in Wistar rats. ( 28665790 )
2017
18
An ulcerated gastric ulcer and pseudotumour with pancreatic affectation associated with immunoglobulin G4-related disease: a case report and literature review. ( 29082738 )
2017
19
A Rare Case of Gastric Ulcer Penetrating the Pancreas that was Successfully Managed by Conservative Therapy. ( 28794357 )
2017
20
Comparison of the therapeutic effects of sildenafil citrate, heparin and neuropeptides in a rat model of acetic acid-induced gastric ulcer. ( 28807720 )
2017
21
Low-Molecular-Weight Oligonol, a Polyphenol Derived from Lychee Fruit, Attenuates Experimental Reflux Esophagitis and HCl/Ethanol-Induced Gastric Ulcer. ( 29243969 )
2017
22
Volatile organic metabolites identify patients with gastric carcinoma, gastric ulcer, or gastritis and control patients. ( 29200968 )
2017
23
Tracheoesophageal fistula after total resection of gastric conduit for gastro-aortic fistula due to gastric ulcer. ( 28831760 )
2017
24
Protective effect of oleane-12-en-3I^-ol-28-oic acid 3I^-D-glucopyranoside in ethanol induced gastric ulcer by enhancing the prostaglandin E2 level. ( 28942137 )
2017
25
Exendin-4, a glucagon-like peptide-1 analogue accelerates healing of chronic gastric ulcer in diabetic rats. ( 29095895 )
2017
26
Cytomegalovirus Gastric Ulcer Complicated with Pyloric Obstruction in a Patient with Ulcerative Colitis. ( 28637105 )
2017
27
Protective effect of salusin-I+ and salusin-I^ against ethanol-induced gastric ulcer in rats. ( 28917082 )
2017
28
Cigarette Lighter Fluid Induced Gastric Ulcer: A Severe Complication of Delayed Foreign Body Removal. ( 28894611 )
2017
29
Enhancement of Gastric Ulcer Healing and Angiogenesis by Hepatocyte Growth Factor Gene Mediated by Attenuated Salmonella in Rats. ( 28049228 )
2017
30
Antiplatelet drug ticagrelor delays gastric ulcer healing in rats. ( 29042978 )
2017
31
Involvement of MAPK/NF-I_B signal transduction pathways: Camellia japonica mitigates inflammation and gastric ulcer. ( 28926923 )
2017
32
Modulatory effect of silymarin on nuclear factor-erythroid-2-related factor 2 regulated redox status, nuclear factor-I_B mediated inflammation and apoptosis in experimental gastric ulcer. ( 28648817 )
2017
33
A Case of Gastric Ulcer With Mucosal Bridge. ( 29308020 )
2017
34
Acute ischemic gastric ulcer. ( 28991536 )
2017
35
Metastatic Renal Cell Carcinoma Presenting as Gastric Ulcer: Case Report and Literature Review. ( 28713604 )
2017
36
Management of Percutaneous Endoscopic Gastrostomy Site Gastric Ulcer in a Patient with an Esophageal Stricture and Hiatus Hernia. ( 28835092 )
2017
37
Gastroprotective and Antiulcer Effects of Celastrus paniculatus Seed Oil Against Several Gastric Ulcer Models in Rats. ( 28816560 )
2017
38
Recurrent gastric ulcer and cholangitis caused by ectopic drainage of the bile duct into the stomach. ( 28868226 )
2017
39
Analyzing the influence of gastric intestinal metaplasia on gastric ulcer healing in Helicobacter pylori-infected patients without atrophic gastritis. ( 28049442 )
2017
40
Protective effects of bilobalide against ethanol-induced gastric ulcer in vivo/vitro. ( 27903426 )
2017
41
Discovery of a COX-2 selective inhibitor hit with anti-inflammatory activity and gastric ulcer protective effect. ( 29076755 )
2017
42
Gastric Ulcer Complications after the Introduction of Proton Pump Inhibitors into Clinical Routine: 20-Year Experience. ( 28785572 )
2017
43
Perforated Gastric Ulcer Associated with Anti-Angiogenic Therapy. ( 29255770 )
2017
44
Management of Giant Gastric Ulcer Perforation: Report of a Case and Review of the Literature. ( 28050305 )
2016
45
Re: Double pylorus from a chronic gastric ulcer: an interesting and rare case. ( 27109304 )
2016
46
Modified pectic polysaccharide from turmeric (Curcuma longa): A potent dietary component against gastric ulcer. ( 26794747 )
2016
47
Protective effect of hydro-alcoholic extract of Ruta graveolens Linn. leaves on indomethacin and pylorus ligation-induced gastric ulcer in rats. ( 27297508 )
2016
48
Erratum: Utilisation of the falciform ligament pedicle flap as an alternative approach for the repair of a perforated gastric ulcer. ( 27664223 )
2016
49
Utilisation of the falciform ligament pedicle flap as an alternative approach for the repair of a perforated gastric ulcer. ( 27102415 )
2016
50
Splenic artery pseudoaneurysm causing brisk upper-GIA bleedA fromA gastric ulcer. ( 26802194 )
2016

Variations for Gastric Ulcer

Expression for Gastric Ulcer

Search GEO for disease gene expression data for Gastric Ulcer.

Pathways for Gastric Ulcer

Pathways related to Gastric Ulcer according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.02 CXCL8 EGF FGF2 HGF IL1B IL1RN
2 12.63 CXCL8 EGF FGF2 HGF PTGS2
3 12.59 EGF FGF2 HGF IL1B
4
Show member pathways
12.52 EGF FGF2 HGF IL1B
5 12.36 IL1B IL1RN PTGS1 PTGS2
6
Show member pathways
12.11 CXCL8 IL1B PTGS2
7
Show member pathways
12.1 EGF HRH2 PTGS2 TFF1
8 12.03 EGF MMP7 PTGS2
9
Show member pathways
12.02 CYP2C19 PTGS1 PTGS2
10 12.02 CXCL8 IL1B IL1RN
11 11.9 EGF FGF2 HGF
12 11.84 CXCL8 IL1B PTGS2
13
Show member pathways
11.82 CYP2C19 PTGS1 PTGS2
14 11.79 CYP2C19 PTGS1 PTGS2
15 11.69 CXCL8 IL1B PTGS2
16 11.5 FGF2 HGF MMP7 PTGS2
17
Show member pathways
11.47 CXCL8 IL1B PTGS2
18 11.41 CXCL8 FGF2 HGF IL1B PTGS2
19 11.3 CXCL8 HGF IL1B
20 11.26 EGF FGF2 HGF
21 11.15 CXCL8 IL1B IL1RN PTGS2
22 11.1 PTGS1 PTGS2
23
Show member pathways
11.08 PTGS1 PTGS2
24 11 PTGS1 PTGS2
25 10.97 PTGS1 PTGS2
26 10.83 CXCL8 EGF FGF2 HGF IL1B
27 10.82 HGF MMP7
28 10.82 CXCL8 EGF FGF2 HGF IL1B
29 10.78 CXCL8 PTGS1 PTGS2
30 10.74 PTGS1 PTGS2
31 10.16 GAST HRH2

GO Terms for Gastric Ulcer

Cellular components related to Gastric Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 CXCL8 EGF FGF2 GAST HGF IL1B
2 organelle membrane GO:0031090 9.33 CYP2C19 PTGS1 PTGS2
3 extracellular space GO:0005615 9.28 CXCL8 EGF FGF2 GAST HGF IL1B

Biological processes related to Gastric Ulcer according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.85 CXCL8 IL1B PTGS2 TFF1
2 positive regulation of cell proliferation GO:0008284 9.8 EGF FGF2 HGF IL1B PTGS2
3 MAPK cascade GO:0000165 9.78 EGF FGF2 HGF IL1B
4 peptidyl-tyrosine phosphorylation GO:0018108 9.76 EGF FGF2 HGF
5 positive regulation of protein kinase B signaling GO:0051897 9.74 EGF FGF2 HGF
6 angiogenesis GO:0001525 9.73 CXCL8 EGF FGF2 PTGS2
7 phosphatidylinositol phosphorylation GO:0046854 9.69 EGF FGF2 HGF
8 inflammatory response GO:0006954 9.65 CXCL8 IL1B IL1RN PTGS1 PTGS2
9 cellular response to mechanical stimulus GO:0071260 9.63 IL1B MMP7 PTGS2
10 positive regulation of vascular endothelial growth factor production GO:0010575 9.59 IL1B PTGS2
11 positive regulation of mitotic nuclear division GO:0045840 9.58 EGF IL1B
12 positive regulation of NF-kappaB import into nucleus GO:0042346 9.56 IL1B PTGS2
13 prostaglandin metabolic process GO:0006693 9.54 PTGS1 PTGS2
14 prostaglandin biosynthetic process GO:0001516 9.52 PTGS1 PTGS2
15 cyclooxygenase pathway GO:0019371 9.49 PTGS1 PTGS2
16 positive regulation of angiogenesis GO:0045766 9.46 CXCL8 FGF2 HGF IL1B
17 fever generation GO:0001660 9.37 IL1B IL1RN
18 positive regulation of fever generation GO:0031622 9.32 IL1B PTGS2
19 activation of MAPK activity GO:0000187 9.26 EGF FGF2 HGF IL1B
20 regulation of receptor activity GO:0010469 9.17 CXCL8 FGF2 GAST HGF IL1B IL1RN

Molecular functions related to Gastric Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.63 EGF FGF2 HGF
2 heme binding GO:0020037 9.58 CYP2C19 PTGS1 PTGS2
3 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.5 EGF FGF2 HGF
4 cytokine activity GO:0005125 9.46 CXCL8 FGF2 IL1B IL1RN
5 peroxidase activity GO:0004601 9.43 PTGS1 PTGS2
6 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.43 EGF FGF2 HGF
7 interleukin-1 receptor binding GO:0005149 9.37 IL1B IL1RN
8 growth factor activity GO:0008083 9.26 EGF FGF2 HGF TFF1
9 prostaglandin-endoperoxide synthase activity GO:0004666 8.62 PTGS1 PTGS2

Sources for Gastric Ulcer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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