MCID: GST023
MIFTS: 67

Gastric Ulcer malady

Gastrointestinal diseases, Ear diseases categories
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Summaries for Gastric Ulcer

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Wikipedia:65 A peptic ulcer is a distinct breach in the mucosal lining of the stomach (gastric ulcer) or the first... more...

MalaCards based summary: Gastric Ulcer, also known as acute gastric ulcer with perforation, is related to esophagitis and duodenal ulcer. An important gene associated with Gastric Ulcer is HRH2 (histamine receptor H2), and among its related pathways are Prostaglandin Synthesis and Regulation and Celecoxib Pathway, Pharmacodynamics. The drugs aluminum hydroxide and aluminum hydroxide gel and the compounds 4-hydroxydiclofenac and lansoprazole have been mentioned in the context of this disorder. Affiliated tissues include small intestine, endothelial and heart, and related mouse phenotypes are tumorigenesis and cardiovascular system.

Aliases & Classifications for Gastric Ulcer

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 57SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 25ICD10
See all sources

Gastric Ulcer, Aliases & Descriptions:

Name: Gastric Ulcer 8 44 62
Acute Gastric Ulcer with Perforation 8 62
Chronic Gastric Ulcer Without Hemorrhage and Without Perforation but with Obstruction 8
Acute Gastric Ulcer Without Hemorrhage, Without Perforation and Without Obstruction 8
Acute Gastric Ulcer with Hemorrhage and Perforation, Without Mention of Obstruction 8
Acute Gastric Ulcer with Hemorrhage and with Perforation but Without Obstruction 8
Acute Gastric Ulcer with Hemorrhage, with Perforation and with Obstruction 8
Acute Gastric Ulcer with Hemorrhage and Perforation, with Obstruction 8
Chronic Gastric Ulcer Without Hemorrhage and Without Perforation 8
Acute Gastric Ulcer Without Hemorrhage and Without Perforation 8
Acute Gastric Ulcer with Perforation, with Obstruction 8
 
Acute Gastric Ulcer with Hemorrhage, with Obstruction 8
Acute Gastric Ulcer with Perforation and Obstruction 8
Acute Gastric Ulcer with Haemorrhage and Perforation 8
Acute Gastric Ulcer with Hemorrhage and Obstruction 8
Acute Gastric Ulcer with Hemorrhage and Perforation 8
Chronic Gastric Ulcer Without Mention of Hemorrhage 8
Acute Gastric Ulcer Without Mention of Hemorrhage 8
Perforation, Without Mention of Obstruction 8
Perforation, with Obstruction 8
Bleeding Acute Gastric Ulcer 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Ear diseases


Related Diseases for Gastric Ulcer

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Diseases related to Gastric Ulcer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 126)
idRelated DiseaseScoreTop Affiliating Genes
1esophagitis31.1CYP2C19, HRH2
2duodenal ulcer31.0TFF1, HRH2, CYP2C19
3atrophic gastritis30.9ODC1, TFF1
4gastroesophageal reflux disease30.4HRH2, CYP2C19, PTGS1
5arthritis30.4PTGS1, HRH2, FGF2
6gastritis30.3CYP2C19, PTGS1, HRH2, TFF1, CCKBR, ODC1
7peptic ulcer disease30.2CYP2C19, PTGS1, HRH2
8ischemia29.9HGF, FGF2, HRH2, NUDT6
9adenoma29.9PTGER2, NUDT6, TFF1, ODC1, PTGS1
10breast cancer29.5FGF2, TFF1, HGF, ODC1
11leukemia29.5HRH2, FGF2, CCKBR, ODC1, PTGS1, NUDT6
12lung cancer29.3TFF1, CYP2C19, HGF, CCKBR
13gastric adenocarcinoma29.3TFF1, ODC1, CCKBR, HGF, HRH2
14stomach cancer29.3CCKBR, HGF, HRH2, TFF1, ODC1
15melanoma29.1ODC1, FGF2, HRH2, HGF, PTGS1, NUDT6
16adenocarcinoma29.0TFF1, NUDT6, HGF, CCKBR, ODC1, PTGS1
17duodenitis10.7
18gastric cancer10.5
19endotheliitis10.5
20duodenogastric reflux10.5
21bile reflux10.5
22blindness10.4
23pancreatitis10.4
24h. pylori infection10.4
25hiatus hernia10.3
26stomach disease10.3HRH2, PTGS1
27hepatocellular carcinoma10.3
28anisakiasis10.3
29aneurysm10.3
30moyamoya disease10.3FGF2, NUDT6
31hypertrophic scars10.2FGF2, NUDT6
32hepatitis10.2
33hypertension10.2
34pernicious anemia10.2
35urticaria10.2PTGS1, HRH2
36factor vii deficiency10.2FGF2, NUDT6
37acute pancreatitis10.1
38splenic abscess10.1
39scrub typhus10.1
40tabes dorsalis10.1
41portal hypertension10.1
42gastric lymphoma10.1
43bacterial gastritis10.1
44gastric dilatation10.1
45gastroenteritis10.1
46pyloric stenosis10.1
47typhus10.1
48autoimmune pancreatitis10.1
49barrett's esophagus10.1ODC1, PTGS1, TFF1
50familial adenomatous polyposis10.1PTGER2, PTGS1, ODC1

Graphical network of the top 20 diseases related to Gastric Ulcer:



Diseases related to gastric ulcer

Symptoms for Gastric Ulcer

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Drugs & Therapeutics for Gastric Ulcer

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Genetic Tests for Gastric Ulcer

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Anatomical Context for Gastric Ulcer

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MalaCards organs/tissues related to Gastric Ulcer:

32
Small intestine, Endothelial, Heart, Liver, Testes, Brain, Colon, Lung, Pancreas, Bone marrow, Bone, Spleen, Thyroid, Breast, Skin, Monocytes, Tongue

Animal Models for Gastric Ulcer or affiliated genes

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MGI Mouse Phenotypes related to Gastric Ulcer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8FGF2, PTGS1, PTGER2, TFF1
2MP:00053857.8FGF2, HGF, CCKBR, PTGS1, PTGER2
3MP:00053767.7TFF1, PTGER2, PTGS1, CCKBR, HRH2, FGF2

Publications for Gastric Ulcer

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Articles related to Gastric Ulcer:

(show top 50)    (show all 674)
idTitleAuthorsYear
1
Trichobezoar causing recurrent gastric ulcer and perforation. (25234936)
2014
2
Hydroxyproline, a serum biomarker candidate for gastric ulcer in rats: a comparison study of metabolic analysis of gastric ulcer models induced by ethanol, stress, and aspirin. (25125970)
2014
3
Healing effects of Musa sapientum var. paradisiaca in diabetic rats with co-occurring gastric ulcer: cytokines and growth factor by PCR amplification. (24192345)
2013
4
Antiulcer activity of water soaked Glycine max L. grains in aspirin induced model of gastric ulcer in Wistar rats. (24250141)
2013
5
Biopsy from the base and edge of gastric ulcer healing or complete healing may lead to detection of gastric cancer earlier: an 8 years endoscopic follow-up study. (22469743)
2012
6
Gastric ulcer and gastroenteritis caused by Epstein-Barr virus during immunosuppressive therapy for a child with systemic juvenile idiopathic arthritis. (22589331)
2012
7
A study on the protective activity of kefir against gastric ulcer. (22965503)
2012
8
Severe erosive esophagitis developing after gastric ulcer formation. (23024739)
2012
9
A biochemical study on the gastroprotective effect of andrographolide in rats induced with gastric ulcer. (22923868)
2011
10
Pharmacokinetic interaction between I/-acetamidocaproic acid (AACA) and cimetidine in indomethacin-induced acute gastric ulcer and control rats: inhibition of active renal secretion of AACA by cimetidine. (21250786)
2011
11
Cytomegalovirus-associated gastric ulcers in a patient with dermatomyositis treated with steroid and cyclophosphamide pulse therapy. (21915824)
2011
12
The protective effect and action mechanism of Vaccinium myrtillus L. on gastric ulcer in mice. (21290441)
2011
13
Role of activation of 5'-adenosine monophosphate-activated protein kinase in gastric ulcer healing in diabetic rats. (22068032)
2011
14
Protective effects of a gastrointestinal agent containing Korean red ginseng on gastric ulcer models in mice. (20718962)
2010
15
Appeal for proper usage of the term 'EGUS': equine gastric ulcer syndrome. (19927576)
2009
16
Equine gastric ulcer syndrome: the continuing conundrum. (19927575)
2009
17
Inhibition of the healing of gastric ulcer by glucocorticoid and its relation to proinflammatory cytokines. (19948431)
2009
18
Gastric anisakiasis associated with bleeding gastric ulcer. (18787284)
2008
19
Rebamipide, anti-gastric ulcer drug, up-regulates the induction of iNOS in proinflammatory cytokine-stimulated hepatocytes. (17936043)
2008
20
Effect of the oral absorption of benzenesulfonanilide-type cyclooxygenase-1 inhibitors on analgesic action and gastric ulcer formation. (18452178)
2008
21
Gastric ulcer after laparoscopic fundoplication for gastroesophageal reflux disease: significance of the eradication of Helicobacter pylori. (17581465)
2007
22
Impairment of gastric ulcer healing by alendronate, a nitrogen-containing bisphosphonate, in rats. (17410434)
2007
23
Genetic variants in matrix metalloproteinase genes are associated with development of gastric ulcer in H. Pylori infection. (16405530)
2006
24
Haplotype analysis of the CD11 gene cluster in patients with chronic Helicobacter pylori infection and gastric ulcer disease. (15730520)
2005
25
Perforated gastric ulcer--reappraisal of surgical options. (16180387)
2005
26
The ameliorative effect of dates (Phoenix dactylifera L.) on ethanol-induced gastric ulcer in rats. (15814265)
2005
27
Cyclo-oxygenase-2 expression and prostaglandin E2 production in experimental chronic gastric ulcer healing. (16139265)
2005
28
Effects of rebamipide, a gastro-protective drug on the Helicobacter pylori status and inflammation in the gastric mucosa of patients with gastric ulcer: a randomized double-blind placebo-controlled multicentre trial. (12925153)
2003
29
Pneumopericardium due to intrapericardial perforation of a gastric ulcer. (12493525)
2003
30
IL-11 up-regulates Tie-2 expression during the healing of gastric ulcers in rats. (12679933)
2003
31
Laparoscopic suture repair of a perforated gastric ulcer in a severely cirrhotic patient with portal hypertension: first case report. (14626407)
2003
32
Effects of sea buckthorn (HippophaA< rhamnoides L.) seed and pulp oils on experimental models of gastric ulcer in rats. (12490224)
2002
33
Polymorphism of CYP2C19 and gastric emptying in patients with proton pump inhibitor-resistant gastric ulcers. (12235924)
2002
34
Upregulation of mucosal soluble fas ligand and interferon-gamma may be involved in ulcerogenesis in patients with Helicobacter pylori-positive gastric ulcer. (12059049)
2002
35
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release. (11353854)
2001
36
Ulcer-healing drugs are required after eradication of Helicobacter pylori in patients with gastric ulcer but not duodenal ulcer haemorrhage. (10930902)
2000
37
Micronutrient antioxidants in gastric mucosa and serum in patients with gastritis and gastric ulcer: does Helicobacter pylori infection affect the mucosal levels? (10875465)
2000
38
Bile reflux due to disturbed gastric movement is a cause of spontaneous gastric ulcer in W/Wv mice. (10389693)
1999
39
Recombinant human transforming growth factor beta 3 accelerates gastric ulcer healing in rats. (9361170)
1997
40
Expression of vascular endothelial growth factor at the human gastric ulcer margin and in cultured gastric fibroblasts: a new angiogenic factor for gastric ulcer healing. (9177300)
1997
41
Focal lesion of African histoplasmosis presenting as a malignant gastric ulcer. (8799429)
1996
42
Cellular and molecular mechanisms of gastric ulcer healing. Is the quality of mucosal scar affected by treatment? (8578218)
1995
43
A new variant case of muscle phosphofructokinase deficiency, coexisting with gastric ulcer, gouty arthritis, and increased hemolysis. (7603526)
1995
44
Gastric ulcer treatment with intravenous human epidermal growth factor: a double-blind controlled clinical study. (7881024)
1994
45
Prostaglandins: viable therapy in gastric ulceration. (8441926)
1993
46
Healthy controls have as much bile reflux as gastric ulcer patients. (3428684)
1987
47
Gastric ulcer and duodenogastric reflux: causal or casual relationship? (6845782)
1983
48
Bile reflux in active and healed gastric ulcer. (5482297)
1970
49
Pneumatosis cystoides intestinalis and large gastric ulcer; report of case. (13667938)
1959
50
Masked perforation of a gastric ulcer in a case of tabes dorsalis. (13094011)
1953

Variations for Gastric Ulcer

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Expression for genes affiliated with Gastric Ulcer

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Expression patterns in normal tissues for genes affiliated with Gastric Ulcer

Search GEO for disease gene expression data for Gastric Ulcer.

Pathways for genes affiliated with Gastric Ulcer

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Compounds for genes affiliated with Gastric Ulcer

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Compounds related to Gastric Ulcer according to GeneCards/GeneDecks:

(show top 50)    (show all 139)
idCompoundScoreTop Affiliating Genes
14-hydroxydiclofenac449.8PTGS1, CYP2C19
2lansoprazole44 50 24 1112.7CYP2C19, HRH2, NUDT6
3diphenhydramine44 28 2 24 1113.6HRH2, PTGS1, CYP2C19
4ns 39844 6110.5PTGS1, PTGER2, FGF2
55-methylthioadenosine449.5NUDT6, FGF2, ODC1
6famotidine44 2 24 1112.5NUDT6, CYP2C19, HRH2
7omeprazole44 50 28 24 1113.3HRH2, CCKBR, CYP2C19
8diclofenac44 28 50 1112.3PTGS1, CYP2C19, HRH2
9amphetamine44 50 1111.3CCKBR, NUDT6, FGF2
10glucosamine44 24 1111.2CYP2C19, PTGS1, FGF2
11ibmx44 61 2811.1PTGER2, FGF2, ODC1, TFF1
12warfarin44 50 24 1111.9CYP2C19, HRH2, FGF2
13diazepam44 28 50 1111.9FGF2, CYP2C19, PTGS1, CCKBR
14acetaminophen44 2 50 24 1112.8HRH2, PTGS1, HGF, CYP2C19
15prostacyclin448.8PTGS1, HGF, FGF2, PTGER2
16hyaluronic acid44 249.7HGF, FGF2, TFF1, PTGS1
17prostaglandin448.7CCKBR, HRH2, ODC1, PTGS1, PTGER2
18thalidomide44 50 61 1111.7FGF2, CYP2C19, HGF, PTGS1
19herbimycin a44 619.6FGF2, PTGS1, HGF, ODC1
20matrigel448.6NUDT6, FGF2, HGF, ODC1
21ethanol44 50 24 1111.5CYP2C19, TFF1, HRH2, HGF
22lactate448.4HGF, ODC1, HRH2, PTGS1, NUDT6
23indomethacin44 28 61 1111.4CYP2C19, PTGS1, TFF1, PTGER2, HGF
24arachidonic acid44 28 24 1111.4CYP2C19, TFF1, HGF, PTGER2, PTGS1
25agar448.4FGF2, HGF, NUDT6, PTGS1, ODC1
26actinomycin d448.3FGF2, TFF1, ODC1, HGF, PTGS1
27paraffin448.3ODC1, PTGS1, TFF1, HGF, FGF2
28histamine44 28 2410.3HGF, PTGER2, ODC1, HRH2, CCKBR
29genistein44 28 61 2 24 1113.3HGF, FGF2, ODC1, PTGS1, TFF1
30estradiol44 24 1110.2TFF1, CYP2C19, NUDT6, CCKBR, HGF
31cycloheximide448.2TFF1, HGF, ODC1, FGF2, PTGS1
32adenylate448.2ODC1, HRH2, HGF, CCKBR, PTGER2
33testosterone44 61 24 1111.2ODC1, HGF, TFF1, NUDT6, CYP2C19
34sb 20358044 619.2ODC1, CCKBR, HGF, FGF2
35h2o2448.2FGF2, HGF, TFF1, PTGS1, ODC1
36vegf448.2PTGER2, NUDT6, PTGS1, HGF, FGF2, TFF1
37aspirin44 50 28 2411.1PTGER2, PTGS1, ODC1, TFF1, HRH2, HGF
38bromodeoxyuridine448.1FGF2, HGF, ODC1, NUDT6, PTGER2, TFF1
39pge2448.1ODC1, FGF2, HRH2, HGF, PTGS1, PTGER2
40dexamethasone44 50 28 1111.0TFF1, CYP2C19, PTGER2, HGF, FGF2, PTGS1
41nitric oxide44 24 119.9PTGS1, CYP2C19, HRH2, ODC1, CCKBR, NUDT6
42glutamate447.8PTGER2, NUDT6, ODC1, CCKBR, HGF, PTGS1
43arginine447.8ODC1, TFF1, NUDT6, HGF, CCKBR
44phosphatidylinositol447.8CCKBR, HGF, FGF2, PTGER2, NUDT6
45estrogen447.7PTGS1, FGF2, HGF, CYP2C19, ODC1, TFF1
46retinoic acid44 248.6FGF2, NUDT6, HRH2, TFF1, HGF, ODC1
47thymidine44 248.5TFF1, CCKBR, FGF2, NUDT6, ODC1, HGF
48nmda44 288.4HGF, FGF2, CCKBR, ODC1, PTGS1, PTGER2
49tyrosine447.2CYP2C19, NUDT6, FGF2, HGF, CCKBR, ODC1
50serine447.1PTGER2, FGF2, HRH2, HGF, CCKBR, PTGS1

GO Terms for genes affiliated with Gastric Ulcer

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Biological processes related to Gastric Ulcer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1gland developmentGO:0487329.7HRH2, CCKBR
2digestive tract developmentGO:0485659.6HRH2, CCKBR
3arachidonic acid metabolic processGO:0193699.4CYP2C19, PTGS1
4positive chemotaxisGO:0509189.2FGF2, HGF
5positive regulation of osteoblast differentiationGO:0456699.2FGF2, HGF
6digestionGO:0075869.2CCKBR, TFF1

Molecular functions related to Gastric Ulcer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemoattractant activityGO:0420569.2FGF2, HGF
2growth factor activityGO:0080838.2FGF2, HGF, NUDT6, TFF1

Products for genes affiliated with Gastric Ulcer

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Sources for Gastric Ulcer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet