MCID: GST023
MIFTS: 72

Gastric Ulcer malady

Gastrointestinal diseases, Ear diseases categories

Summaries for Gastric Ulcer

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63Wikipedia, 32MalaCards
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Wikipedia:63 A peptic ulcer, stomach ulcer or gastric ulcer, also known as peptic ulcer disease (PUD), is a distinct... more...

MalaCards: Gastric Ulcer, also known as chronic gastric ulcer without hemorrhage and without perforation but with obstruction, is related to gastritis and duodenal ulcer. An important gene associated with Gastric Ulcer is HRH2 (histamine receptor H2), and among its related pathways are p70S6K Signaling and NF-KappaB Family Pathway. The drugs aluminum hydroxide and aluminum hydroxide gel and the compounds pge2 and bromodeoxyuridine have been mentioned in the context of this disorder. Affiliated tissues include endothelial, pancreas and testes, and related mouse phenotypes are digestive/alimentary and homeostasis/metabolism.

Aliases & Classifications for Gastric Ulcer

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Ear diseases


Aliases & Descriptions:

gastric ulcer 8 44 60
chronic gastric ulcer without hemorrhage and without perforation but with obstruction 8
acute gastric ulcer without hemorrhage, without perforation and without obstruction 8
acute gastric ulcer with hemorrhage and perforation, without mention of obstruction 8
acute gastric ulcer with hemorrhage and with perforation but without obstruction 8
acute gastric ulcer with hemorrhage, with perforation and with obstruction 8
acute gastric ulcer with hemorrhage and perforation, with obstruction 8
chronic gastric ulcer without hemorrhage and without perforation 8
acute gastric ulcer without hemorrhage and without perforation 8
acute gastric ulcer with perforation, with obstruction 8
acute gastric ulcer with hemorrhage, with obstruction 8
acute gastric ulcer with perforation and obstruction 8
acute gastric ulcer with haemorrhage and perforation 8
acute gastric ulcer with hemorrhage and obstruction 8
acute gastric ulcer with hemorrhage and perforation 8
chronic gastric ulcer without mention of hemorrhage 8
acute gastric ulcer without mention of hemorrhage 8
perforation, without mention of obstruction 8
acute gastric ulcer with perforation 8
perforation, with obstruction 8
bleeding acute gastric ulcer 8


Related Diseases for Gastric Ulcer

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17GeneCards, 18GeneDecks
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Diseases related to Gastric Ulcer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 181)
idRelated DiseaseScoreTop Affiliating Genes
1gastritis31.0S100A8, GAST, TFF1, TFF2, MUC5AC, HRH2
2duodenal ulcer30.9S100A8, GAST, HRH2
3duodenitis30.9S100A8, GAST
4esophagitis30.7S100A8, GAST, HRH2
5bile reflux30.6TFF1
6atrophic gastritis30.5ODC1, S100A8, GAST, TFF1, TFF2
7hepatocellular carcinoma30.3HGF, CCKBR, S100A8, TFF3, MUC5AC, EPRS
8peptic ulcer30.2S100A8, GAST, MUC5AC, HRH2, PTGS1, PTGS2
9hepatitis30.2HRH2, HGF
10arthritis30.2S100A8, EPRS, FGF2, HRH2, SRF, PTGS1
11gastroenteritis30.1TFF3
12gastroesophageal reflux disease30.1S100A8, GAST, HRH2, PTGS1
13ischemia30.1HGF, NUDT6, EPRS, FGF2, HRH2, GSR
14gastric adenocarcinoma30.1ODC1, HGF, CCKBR, S100A8, GAST, TFF1
15acute pancreatitis30.1HRH2
16adenoma30.1GSR, PTGS2, PTGER2, ODC1, S100A8, GAST
17adenocarcinoma30.1EGF, MUC5AC, NUDT6, SRF, PTGS1, PTGER2
18gastroduodenitis29.9GAST
19dyspepsia29.9HRH2, GAST
20stomach cancer29.9GAST
21pneumonia29.9S100A8, HRH2, PTGS1
22esophageal cancer29.9PTGS2
23melanoma29.9ODC1, HGF, NUDT6, EPRS, FGF2, HRH2
24leukemia29.9ODC1, CCKBR, S100A8, EGF, NUDT6, FGF2
25lung cancer29.9ODC1, HGF, TFF1, EGF, MUC5AC, PTGER2
26diabetes mellitus29.9GSR
27dermatomyositis29.9S100A8
28breast cancer29.9ODC1, TFF1, EGF, PTGS2
29hyperparathyroidism29.9GAST
30duodenogastric reflux10.5
31pancreatitis10.4
32hiatus hernia10.3
33splenic abscess10.2
34pernicious anemia10.2
35hypertension10.2
36anisakiasis10.1
37gastric dilatation10.1
38tabes dorsalis10.1
39gastric lymphoma10.1
40portal hypertension10.1
41bacterial gastritis10.1
42gastrojejunal ulcer10.1
43adult syndrome10.1
44scrub typhus10.1
45hepatitis a10.1
46pyloric stenosis10.1
47typhus10.1
48cystic fibrosis10.0S100A8, MUC5AC
49cholesteatoma10.0S100A8
50endometrial carcinoma10.0PTGER2, MUC5AC, EGF, TFF1

Graphical network of the top 20 diseases related to Gastric Ulcer:



Diseases related to gastric ulcer

Clinical Features for Gastric Ulcer

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Drugs & Therapeutics for Gastric Ulcer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Gastric Ulcer

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Anatomical Context for Gastric Ulcer

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32MalaCards
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MalaCards organs/tissues related to Gastric Ulcer:

32
Endothelial, Pancreas, Testes, Colon, Liver, T cells, Heart, Bone marrow, Lung, Bone, Brain, Lymph node, Monocytes, Myeloid, Spleen, Skin, Breast, Thyroid, Tongue

Animal Models for Gastric Ulcer or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Gastric Ulcer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538110.5PTGS2, CCKBR, GAST, TFF1, TFF2, TFF3
2MP:000537610.4CCKBR, GAST, TFF2, TFF3, MUC5AC, HRH2
3MP:000537910.4PTGS1, EGF, TFF2, GAST, CCKBR
4MP:000538710.4CCKBR, GAST, TFF2, TFF3, EGF, MUC5AC
5MP:000200610.4GAST, TFF1
6MP:000538510.1HGF, CCKBR, FGF2, SRF, PTGS1, PTGER2

Publications for Gastric Ulcer

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50PubMed
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Articles related to Gastric Ulcer:

(show top 50)    (show all 959)
idTitleAuthorsYear
1
Protective effect of chelerythrine against ethanol-induced gastric ulcer in mice. (24300194)
2014
2
Association of Helicobacter pylori babA2 with peptic ulcer disease and gastric cancer. (23864790)
2013
3
Polysaccharide-rich fraction of Termitomyces eurhizus accelerate healing of indomethacin induced gastric ulcer in mice. (23715800)
2013
4
Expression and significance of trefoil factor 1 protein and serum pepsinogen in benign and malignant gastric ulcers]. (22944057)
2012
5
Giant gastric ulcer: a challenging diagnosis in the deployed military environment. (22479927)
2012
6
Effects of hecogenin and its possible mechanism of action on experimental models of gastric ulcer in mice. (22426163)
2012
7
Single-incision laparoscopy-assisted subtotal gastrectomy for intractable gastric ulcer: a case report. (22874703)
2012
8
Ameliorative effects of telmisartan in diabetic rats with indomethacin-induced gastric ulceration. (20399771)
2010
9
Involvement of orexigenic peptides in the mechanism of gastric mucosal integrity and healing of chronic gastric ulcers. (20166991)
2010
10
Immune reactions against elongation factor 2 kinase: specific pathogenesis of gastric ulcer from Helicobacter pylori infection. (19636416)
2009
11
Effect of transcranial electrostimulation on clinical and laboratory characteristics in patients with gastric ulcer]. (19708562)
2009
12
Gastroprotective effect of simvastatin against indomethacin-induced gastric ulcer in rats: role of nitric oxide and prostaglandins. (19217901)
2009
13
Effect of the oral absorption of benzenesulfonanilide-type cyclooxygenase-1 inhibitors on analgesic action and gastric ulcer formation. (18452178)
2008
14
A case of adult-onset Satoyoshi syndrome with gastric ulceration and eosinophilic enteritis. (18607399)
2008
15
Novel roles of local insulin-like growth factor-1 activation in gastric ulcer healing: promotes actin polymerization, cell proliferation, re-epithelialization, and induces cyclooxygenase-2 in a phosphatidylinositol 3-kinase-dependent manner. (17392162)
2007
16
Penetrating gastric ulcer presenting as a subcapsular liver abscess. (17249464)
2007
17
Genetic variants in matrix metalloproteinase genes are associated with development of gastric ulcer in H. Pylori infection. (16405530)
2006
18
Duodenal ulcer and gastric cancer; rare association or an indication for a change of policy? (16115169)
2005
19
Helicobacter pylori infection, glandular atrophy and intestinal metaplasia in superficial gastritis, gastric erosion, erosive gastritis, gastric ulcer and early gastric cancer. (15682469)
2005
20
Eosinophil infiltration, gastric juice and serum eosinophil cationic protein levels in Helicobacter pylori-associated chronic gastritis and gastric ulcer. (15770055)
2004
21
Mucosal concentration of basic fibroblast growth factor in the healing process in human giant gastric ulcers. (15086596)
2004
22
Gastric ulcer penetrating to liver diagnosed by endoscopic biopsy. (15188520)
2004
23
Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, accelerates gastric ulcer healing in rat. (12871756)
2003
24
babA2- and cagA-positive Helicobacter pylori strains are associated with duodenal ulcer and gastric carcinoma in Brazil. (12904430)
2003
25
A novel antioxidant and antiapoptotic role of omeprazole to block gastric ulcer through scavenging of hydroxyl radical. (12529378)
2003
26
The effect of nimesulide on the indomethacin- and ethanol-induced gastric ulcer in rats. (11846629)
2002
27
Helicobacter pylori influence on gastric acid secretion in duodenal ulcer patients diagnosed for the first time. (11887086)
2002
28
Healing-promoting effect of bombesin treatment on chronic gastric ulcer in rats. (12047914)
2002
29
Impairment of gastric secretion modulation in duodenal ulcer and in long-term PPI treatment: quantitative morphologic findings and pathophysiologic implications. (11575448)
2001
30
Gastroprotective effect of aparisthman, a diterpene isolated from Aparisthmium cordatum, on experimental gastric ulcer models in rats and mice. (11315762)
2001
31
Diminished Th1-type cytokine production in gastric mucosa T-lymphocytes after H. pylori eradication in duodenal ulcer patients. (11005624)
2000
32
Matrix metalloproteinases 2 and 9 in indomethacin-induced rat gastric ulcer. (10878458)
2000
33
Diminished interferon-gamma production in gastric mucosa T lymphocytes after H. pylori eradication in duodenal ulcer patients. (10430335)
1999
34
Serological response to Helicobacter pylori recombinant antigens in Chilean infected patients with duodenal ulcer, non-ulcer dyspepsia and gastric cancer. (10660136)
1999
35
Regional differences on production of chemokines in gastric mucosa between Helicobacter pylori-positive duodenal ulcer and gastric ulcer. (10630487)
1999
36
Effects of Helicobacter pylori on gastritis, pentagastrin-stimulated gastric acid secretion, and meal-stimulated plasma gastrin release in the absence of peptic ulcer disease. (9707051)
1998
37
Prevention of gastric ulcer relapse induced by indomethacin in rats by a mutein of basic fibroblast growth factor. (9127818)
1997
38
Famotidine for the prevention of gastric and duodenal ulcers caused by nonsteroidal antiinflammatory drugs. (8618582)
1996
39
Gastric ulcer healing and basic fibroblast growth factor: effects of lansoprazole and famotidine. (7594320)
1995
40
Partial gastric resection for peptic ulcer--comparison of the effect of variant reconstructive procedures on gastric emptying, gastric acid secretion and gastrin release in the early postoperative period I. Roux-en-Y and Billroth-II gastroenteroanastomosis. (7828490)
1994
41
Effect of a histamine H2 type receptor antagonist (WY 45, 727) on the healing of gastric ulcers in ponies. (1359134)
1992
42
Adenosine deaminase activity in the gastric mucosa in patients with gastric ulcer. Effects of ranitidine and sucralfate. (1811991)
1991
43
Effect of alkalies on gastric acidity in patients with duodenal ulcer]. (2075140)
1990
44
The possible role of duodenogastric reflux in the pathogenesis of both gastric and duodenal ulcers. (6588505)
1984
45
Gastric ulcer and duodenogastric reflux: causal or casual relationship? (6845782)
1983
46
Recurrent upper gastro-intestinal bleeding, duodenal and gastric ulcer and peliosis hepatis in a patient with Waldenstrom's macroglobulinemia. (121791)
1979
47
Comparison of basal gastric acid and pepsin output in controls vs. active peptic ulcer disease (PUD). (358827)
1978
48
Benign gastric ulcer in a patient with pernicious anemia. (1158091)
1975
49
Duodenal ulcer stenosis with gastric dilatation. Treatment by vagotomy and pyloroplasty. (5546330)
1971
50
The importance of the spatial relationship of the gastric antrum in the development of gastrojejunal ulcer in the dog. (13187294)
1953

Genetic Variations for Gastric Ulcer

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Expression for genes affiliated with Gastric Ulcer

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gastric Ulcer

Search GEO for disease gene expression data for Gastric Ulcer.

Pathways for genes affiliated with Gastric Ulcer

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51QIAGEN, 49PharmGKB, 37NCBI BioSystems Database, 12EMD Millipore, 53Reactome, 29KEGG
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Compounds for genes affiliated with Gastric Ulcer

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44Novoseek, 49PharmGKB, 28IUPHAR, 24HMDB, 59Tocris Bioscience, 11DrugBank, 2BitterDB
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Compounds related to Gastric Ulcer according to GeneCards/GeneDecks:

(show top 50)    (show all 198)
idCompoundScoreTop Affiliating Genes
1pge24410.9PTGS2
2bromodeoxyuridine4410.9FGF2, NUDT6, EGF, TFF1, PTGER2, GAST
3aspirin44 49 28 2413.9HRH2, TFF3, TFF2, TFF1, PTGER2, ODC1
4nmda44 2811.8FGF2, GSR, PTGER2, PTGS1, SRF, EPRS
5glutamate4410.8GAST, CCKBR, EPRS, SRF
6indomethacin44 59 28 1113.8PTGS2, TFF2, PTGS1, TFF3, GSR, PTGER2
7thymidine44 2411.8ODC1, HGF, GAST, CCKBR, TFF1, SRF
8prostaglandin4410.8PTGER2, PTGS1, MUC5AC, HRH2, ODC1, CCKBR
9sucralfate44 1111.8HRH2, FGF2, EGF, GAST
10dexamethasone44 49 28 1113.8TFF1, S100A8, MUC5AC, HGF, PTGER2, PTGS2
11agar4410.8EGF, PTGS1, SRF, NUDT6, S100A8, HGF
12serine4410.8PTGS1, HRH2, EPRS, FGF2, CCKBR, S100A8
13misoprostol44 1111.8GAST, PTGER2, HRH2, PTGS2
14genistein44 28 59 2 11 2415.8HGF, GSR, PTGS2, ODC1, SRF, FGF2
15vegf4410.8HGF, GAST, TFF1, NUDT6, SRF, PTGS1
16actinomycin d4410.8TFF1, FGF2, ODC1, TFF3, PTGS1, PTGS2
17sb 20358044 5911.8MUC5AC, PTGS2, EGF, CCKBR, HGF, ODC1
18histamine44 28 2412.8ODC1, HRH2, MUC5AC, GAST, S100A8, CCKBR
19arachidonic acid44 28 11 2413.8HGF, S100A8, TFF1, TFF2, PTGS2, PTGER2
20cycloheximide4410.8HGF, TFF1
21nitric oxide44 11 2412.8ODC1, CCKBR, S100A8, TFF3, PTGS2, SRF
22nicotinamide44 1111.8EPRS, GSR, HRH2, GAST, HGF
23herbimycin a44 5911.8PTGS1, ODC1, PTGS2, HGF, EGF, FGF2
24h2o24410.8HGF, ODC1, TFF1, TFF3, EGF, EPRS
25paraffin4410.8PTGS1, ODC1, HGF, S100A8, TFF1, TFF3
26acetaminophen44 2 49 11 2414.8HRH2
27methotrexate44 49 1112.8ODC1, SRF, S100A8, HGF, GSR, MUC5AC
28retinoic acid44 2411.8FGF2, TFF1, HRH2, NUDT6, MUC5AC, EGF
29celecoxib44 59 28 49 11 2415.8GAST, FGF2, PTGS2, HRH2, PTGS1
30adenylate4410.8ODC1, HGF, CCKBR, GAST, HRH2, EGF
31phosphatidylinositol4410.8MUC5AC, SRF, FGF2, HGF, CCKBR, EGF
32tyrosine4410.7CCKBR, PTGER2, SRF, EPRS, HGF, S100A8
33pd 98,0594410.7EGF, TFF3, MUC5AC, NUDT6, FGF2, PTGS2
34ag 14784410.7PTGS2, GAST, EGF, MUC5AC, HGF
35calcium44 49 11 2413.7EGF, MUC5AC, EPRS, HRH2, PTGER2, SRF
36thromboxane a244 2411.7PTGS1, PTGER2, PTGS2, EPRS, TFF3
37thalidomide44 49 59 1113.7FGF2, S100A8, HGF, PTGS2, PTGS1
38oxygen44 2411.7PTGS1, S100A8, HGF, HRH2
39testosterone44 59 11 2413.7EGF, HGF, ODC1, NUDT6, SRF, GAST
40k252a4410.7EGF, FGF2, SRF, HGF
41suramin44 28 1112.6NUDT6, SRF
42cysteine4410.6TFF3, ODC1, S100A8, GSR, PTGS1, TFF1
43retinoid4410.6SRF, MUC5AC, TFF1, S100A8, HGF, ODC1
44matrigel4410.6ODC1, EGF, NUDT6
45lactate4410.6ODC1, SRF, HGF, NUDT6, HRH2, PTGS1
46ornithine44 2411.5GAST, CCKBR, HGF, ODC1, SRF
47resveratrol44 59 11 2413.4PTGS1, TFF1, GAST, ODC1
48omeprazole44 28 49 11 2414.4HRH2, GAST, S100A8, CCKBR
49n acetylcysteine4410.3ODC1, HGF, EPRS, MUC5AC, GSR, PTGS2
50gf 109203x44 5911.1EGF, FGF2, PTGER2, PTGS2, GAST

GO Terms for genes affiliated with Gastric Ulcer

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16Gene Ontology
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Cellular components related to Gastric Ulcer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.4FGF2, EGF, TFF2, TFF1, S100A8, HGF

Biological processes related to Gastric Ulcer according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cerebellar granule cell precursor proliferationGO:02194010.6EGF, FGF2
2digestionGO:00758610.6MUC5AC, TFF3, TFF2, TFF1, CCKBR
3gland developmentGO:04873210.6HRH2, CCKBR
4positive regulation of cell proliferationGO:00828410.5ODC1, CCKBR, TFF2, EGF, FGF2
5cyclooxygenase pathwayGO:01937110.5PTGS2, PTGS1
6prostaglandin biosynthetic processGO:00151610.5PTGS1, PTGS2
7positive regulation of smooth muscle contractionGO:04598710.4PTGS2, SRF
8cell migration involved in sprouting angiogenesisGO:00204210.2FGF2, SRF

Molecular functions related to Gastric Ulcer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1prostaglandin-endoperoxide synthase activityGO:00466610.5PTGS2, PTGS1
2growth factor activityGO:00808310.2FGF2, NUDT6, EGF, TFF1, HGF

Products for genes affiliated with Gastric Ulcer

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Gastric Ulcer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet