MCID: GST023
MIFTS: 67

Gastric Ulcer malady

Gastrointestinal diseases, Ear diseases categories

Summaries for Gastric Ulcer

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66Wikipedia, 34MalaCards
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Wikipedia:66 A peptic ulcer is a distinct breach in the mucosal lining of the stomach (gastric ulcer) or the first... more...

MalaCards: Gastric Ulcer, also known as chronic gastric ulcer without hemorrhage and without perforation but with obstruction, is related to gastritis and esophagitis. An important gene associated with Gastric Ulcer is HRH2 (histamine receptor H2), and among its related pathways are Prostaglandin Synthesis and Regulation and Celecoxib Pathway, Pharmacodynamics. The drugs aluminum hydroxide and aluminum hydroxide gel and the compounds 4-hydroxydiclofenac and lansoprazole have been mentioned in the context of this disorder. Affiliated tissues include small intestine, endothelial and liver, and related mouse phenotypes are tumorigenesis and cardiovascular system.

Aliases & Classifications for Gastric Ulcer

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9Disease Ontology, 46Novoseek, 63UMLS, 59SNOMED-CT, 36MeSH, 41NCIt, 28ICD9CM, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Ear diseases


Aliases & Descriptions:

gastric ulcer 9 46 63
chronic gastric ulcer without hemorrhage and without perforation but with obstruction 9
acute gastric ulcer without hemorrhage, without perforation and without obstruction 9
acute gastric ulcer with hemorrhage and perforation, without mention of obstruction 9
acute gastric ulcer with hemorrhage and with perforation but without obstruction 9
acute gastric ulcer with hemorrhage, with perforation and with obstruction 9
acute gastric ulcer with hemorrhage and perforation, with obstruction 9
chronic gastric ulcer without hemorrhage and without perforation 9
acute gastric ulcer without hemorrhage and without perforation 9
acute gastric ulcer with perforation, with obstruction 9
acute gastric ulcer with hemorrhage, with obstruction 9
acute gastric ulcer with perforation and obstruction 9
acute gastric ulcer with haemorrhage and perforation 9
acute gastric ulcer with hemorrhage and obstruction 9
chronic gastric ulcer without mention of hemorrhage 9
acute gastric ulcer with hemorrhage and perforation 9
acute gastric ulcer without mention of hemorrhage 9
perforation, without mention of obstruction 9
acute gastric ulcer with perforation 9
perforation, with obstruction 9
bleeding acute gastric ulcer 9


Related Diseases for Gastric Ulcer

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18GeneCards, 19GeneDecks
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Diseases related to Gastric Ulcer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 119)
idRelated DiseaseScoreTop Affiliating Genes
1gastritis30.9CYP2C19, PTGS1, HRH2, TFF1, CCKBR, ODC1
2esophagitis30.9CYP2C19, HRH2
3duodenal ulcer30.7TFF1, HRH2, CYP2C19
4atrophic gastritis30.7ODC1, TFF1
5arthritis30.3PTGS1, HRH2, FGF2
6hepatocellular carcinoma30.3CYP2C19, FGF2, HGF, CCKBR
7gastroesophageal reflux disease30.2HRH2, CYP2C19, PTGS1
8ischemia30.1HGF, FGF2, HRH2, NUDT6
9peptic ulcer disease30.0CYP2C19, PTGS1, HRH2
10adenocarcinoma29.9TFF1, NUDT6, HGF, CCKBR, ODC1, PTGS1
11adenoma29.9PTGER2, NUDT6, TFF1, ODC1, PTGS1
12breast cancer29.8FGF2, TFF1, HGF, ODC1
13lung cancer29.8TFF1, CYP2C19, HGF, CCKBR
14gastric adenocarcinoma29.8TFF1, ODC1, CCKBR, HGF, HRH2
15stomach cancer29.8CCKBR, HGF, HRH2, TFF1, ODC1
16leukemia29.8HRH2, FGF2, CCKBR, ODC1, PTGS1, NUDT6
17melanoma29.8ODC1, FGF2, HRH2, HGF, PTGS1, NUDT6
18duodenitis10.6
19endotheliitis10.5
20duodenogastric reflux10.5
21bile reflux10.5
22blindness10.4
23pancreatitis10.4
24h. pylori infection10.4
25hiatus hernia10.3
26aneurysm10.3
27pernicious anemia10.2
28hypertension10.2
29anisakiasis10.1
30acute pancreatitis10.1
31portal hypertension10.1
32splenic abscess10.1
33gastric lymphoma10.1
34bacterial gastritis10.1
35gastric dilatation10.1
36tabes dorsalis10.1
37scrub typhus10.1
38gastroenteritis10.1
39hepatitis10.1
40pyloric stenosis10.1
41typhus10.1
42autoimmune pancreatitis10.1
43stomach disease10.1HRH2, PTGS1
44moyamoya disease10.1FGF2, NUDT6
45hypertrophic scars10.1FGF2, NUDT6
46urticaria10.1PTGS1, HRH2
47factor vii deficiency10.0FGF2, NUDT6
48barrett's esophagus10.0ODC1, PTGS1, TFF1
49familial adenomatous polyposis10.0PTGER2, PTGS1, ODC1
50bladder carcinoma10.0ODC1, NUDT6, FGF2

Graphical network of the top 20 diseases related to Gastric Ulcer:



Diseases related to gastric ulcer

Symptoms for Gastric Ulcer

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Drugs & Therapeutics for Gastric Ulcer

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Genetic Tests for Gastric Ulcer

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Anatomical Context for Gastric Ulcer

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34MalaCards
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MalaCards organs/tissues related to Gastric Ulcer:

34
Small intestine, Endothelial, Liver, Heart, Testes, Pancreas, Lung, Colon, Breast, Monocytes, Bone marrow, Bone, Tongue, Brain, Skin

Animal Models for Gastric Ulcer or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Gastric Ulcer:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8TFF1, PTGER2, PTGS1, FGF2
2MP:00053857.8PTGER2, PTGS1, CCKBR, HGF, FGF2
3MP:00053767.7TFF1, PTGER2, PTGS1, CCKBR, HRH2, FGF2

Publications for Gastric Ulcer

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53PubMed
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Articles related to Gastric Ulcer:

(show top 50)    (show all 644)
idTitleAuthorsYear
1
Antiulcer activity of water soaked Glycine max L. grains in aspirin induced model of gastric ulcer in Wistar rats. (24250141)
2013
2
Gastric ulcer and gastroenteritis caused by Epstein-Barr virus during immunosuppressive therapy for a child with systemic juvenile idiopathic arthritis. (22589331)
2012
3
A study on the protective activity of kefir against gastric ulcer. (22965503)
2012
4
Severe erosive esophagitis developing after gastric ulcer formation. (23024739)
2012
5
Nonsteroidal anti-inflammatory drug-activated gene-1 plays a role in the impairing effects of cyclooxygenase inhibitors on gastric ulcer healing. (22495067)
2012
6
A biochemical study on the gastroprotective effect of andrographolide in rats induced with gastric ulcer. (22923868)
2011
7
Pharmacokinetic interaction between I/-acetamidocaproic acid (AACA) and cimetidine in indomethacin-induced acute gastric ulcer and control rats: inhibition of active renal secretion of AACA by cimetidine. (21250786)
2011
8
Cytomegalovirus-associated gastric ulcers in a patient with dermatomyositis treated with steroid and cyclophosphamide pulse therapy. (21915824)
2011
9
The protective effect and action mechanism of Vaccinium myrtillus L. on gastric ulcer in mice. (21290441)
2011
10
Role of activation of 5'-adenosine monophosphate-activated protein kinase in gastric ulcer healing in diabetic rats. (22068032)
2011
11
Protective effects of a gastrointestinal agent containing Korean red ginseng on gastric ulcer models in mice. (20718962)
2010
12
Appeal for proper usage of the term 'EGUS': equine gastric ulcer syndrome. (19927576)
2009
13
Equine gastric ulcer syndrome: the continuing conundrum. (19927575)
2009
14
Immune reactions against elongation factor 2 kinase: specific pathogenesis of gastric ulcer from Helicobacter pylori infection. (19636416)
2009
15
Gastric anisakiasis associated with bleeding gastric ulcer. (18787284)
2008
16
Rebamipide, anti-gastric ulcer drug, up-regulates the induction of iNOS in proinflammatory cytokine-stimulated hepatocytes. (17936043)
2008
17
Effect of the oral absorption of benzenesulfonanilide-type cyclooxygenase-1 inhibitors on analgesic action and gastric ulcer formation. (18452178)
2008
18
Gastric ulcer after laparoscopic fundoplication for gastroesophageal reflux disease: significance of the eradication of Helicobacter pylori. (17581465)
2007
19
Genetic variants in matrix metalloproteinase genes are associated with development of gastric ulcer in H. Pylori infection. (16405530)
2006
20
The effect of Helicobacter pylori eradication therapy on gastric ulcer healing after endoscopic mucosal resection. (16633099)
2006
21
Haplotype analysis of the CD11 gene cluster in patients with chronic Helicobacter pylori infection and gastric ulcer disease. (15730520)
2005
22
Perforated gastric ulcer--reappraisal of surgical options. (16180387)
2005
23
The ameliorative effect of dates (Phoenix dactylifera L.) on ethanol-induced gastric ulcer in rats. (15814265)
2005
24
Cyclo-oxygenase-2 expression and prostaglandin E2 production in experimental chronic gastric ulcer healing. (16139265)
2005
25
Gastric ulcer detected incidentally by renal scintigraphy. (15599016)
2004
26
Effects of rebamipide, a gastro-protective drug on the Helicobacter pylori status and inflammation in the gastric mucosa of patients with gastric ulcer: a randomized double-blind placebo-controlled multicentre trial. (12925153)
2003
27
Pneumopericardium due to intrapericardial perforation of a gastric ulcer. (12493525)
2003
28
IL-11 up-regulates Tie-2 expression during the healing of gastric ulcers in rats. (12679933)
2003
29
Laparoscopic suture repair of a perforated gastric ulcer in a severely cirrhotic patient with portal hypertension: first case report. (14626407)
2003
30
Effects of sea buckthorn (HippophaA< rhamnoides L.) seed and pulp oils on experimental models of gastric ulcer in rats. (12490224)
2002
31
Polymorphism of CYP2C19 and gastric emptying in patients with proton pump inhibitor-resistant gastric ulcers. (12235924)
2002
32
Upregulation of mucosal soluble fas ligand and interferon-gamma may be involved in ulcerogenesis in patients with Helicobacter pylori-positive gastric ulcer. (12059049)
2002
33
HTLV-I carrier status disclosed at diagnosis of cytomegalovirus gastric ulcer. (12533056)
2002
34
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release. (11353854)
2001
35
Ulcer-healing drugs are required after eradication of Helicobacter pylori in patients with gastric ulcer but not duodenal ulcer haemorrhage. (10930902)
2000
36
Micronutrient antioxidants in gastric mucosa and serum in patients with gastritis and gastric ulcer: does Helicobacter pylori infection affect the mucosal levels? (10875465)
2000
37
Bile reflux due to disturbed gastric movement is a cause of spontaneous gastric ulcer in W/Wv mice. (10389693)
1999
38
Recombinant human transforming growth factor beta 3 accelerates gastric ulcer healing in rats. (9361170)
1997
39
Expression of vascular endothelial growth factor at the human gastric ulcer margin and in cultured gastric fibroblasts: a new angiogenic factor for gastric ulcer healing. (9177300)
1997
40
Focal lesion of African histoplasmosis presenting as a malignant gastric ulcer. (8799429)
1996
41
Cellular and molecular mechanisms of gastric ulcer healing. Is the quality of mucosal scar affected by treatment? (8578218)
1995
42
A new variant case of muscle phosphofructokinase deficiency, coexisting with gastric ulcer, gouty arthritis, and increased hemolysis. (7603526)
1995
43
Gastric ulcer treatment with intravenous human epidermal growth factor: a double-blind controlled clinical study. (7881024)
1994
44
Prostaglandins: viable therapy in gastric ulceration. (8441926)
1993
45
Healthy controls have as much bile reflux as gastric ulcer patients. (3428684)
1987
46
Gastric ulcer and duodenogastric reflux: causal or casual relationship? (6845782)
1983
47
Bile reflux in active and healed gastric ulcer. (5482297)
1970
48
Pneumatosis cystoides intestinalis and large gastric ulcer; report of case. (13667938)
1959
49
Peptic esophagitis with duodenal or gastric ulcer. (13129060)
1954
50
Masked perforation of a gastric ulcer in a case of tabes dorsalis. (13094011)
1953

Variations for Gastric Ulcer

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Expression for genes affiliated with Gastric Ulcer

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gastric Ulcer

Search GEO for disease gene expression data for Gastric Ulcer.

Pathways for genes affiliated with Gastric Ulcer

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51PathCards, 39NCBI BioSystems Database, 52PharmGKB, 56Reactome, 61Thomson Reuters, 54QIAGEN
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Compounds for genes affiliated with Gastric Ulcer

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Sources:
46Novoseek, 52PharmGKB, 25HMDB, 12DrugBank, 30IUPHAR, 3BitterDB, 62Tocris Bioscience
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Compounds related to Gastric Ulcer according to GeneCards/GeneDecks:

(show top 50)    (show all 139)
idCompoundScoreTop Affiliating Genes
14-hydroxydiclofenac469.8PTGS1, CYP2C19
2lansoprazole46 52 25 1212.7CYP2C19, HRH2, NUDT6
3diphenhydramine46 30 3 25 1213.6HRH2, PTGS1, CYP2C19
4ns 39846 6210.5PTGS1, PTGER2, FGF2
55-methylthioadenosine469.5NUDT6, FGF2, ODC1
6famotidine46 3 25 1212.5NUDT6, CYP2C19, HRH2
7omeprazole46 52 30 25 1213.3HRH2, CCKBR, CYP2C19
8diclofenac46 30 52 1212.3PTGS1, CYP2C19, HRH2
9amphetamine46 52 1211.3CCKBR, NUDT6, FGF2
10glucosamine46 25 1211.2CYP2C19, PTGS1, FGF2
11ibmx46 62 3011.1PTGER2, FGF2, ODC1, TFF1
12warfarin46 52 25 1211.9CYP2C19, HRH2, FGF2
13diazepam46 30 52 1211.9FGF2, CYP2C19, PTGS1, CCKBR
14acetaminophen46 3 52 25 1212.8HRH2, PTGS1, HGF, CYP2C19
15prostacyclin468.8PTGS1, HGF, FGF2, PTGER2
16hyaluronic acid46 259.7HGF, FGF2, TFF1, PTGS1
17prostaglandin468.7CCKBR, HRH2, ODC1, PTGS1, PTGER2
18thalidomide46 52 62 1211.7FGF2, CYP2C19, HGF, PTGS1
19herbimycin a46 629.6FGF2, PTGS1, HGF, ODC1
20matrigel468.6NUDT6, FGF2, HGF, ODC1
21ethanol46 52 25 1211.5CYP2C19, TFF1, HRH2, HGF
22lactate468.4HGF, ODC1, HRH2, PTGS1, NUDT6
23indomethacin46 30 62 1211.4CYP2C19, PTGS1, TFF1, PTGER2, HGF
24arachidonic acid46 30 25 1211.4CYP2C19, TFF1, HGF, PTGER2, PTGS1
25agar468.4FGF2, HGF, NUDT6, PTGS1, ODC1
26actinomycin d468.3FGF2, TFF1, ODC1, HGF, PTGS1
27paraffin468.3ODC1, PTGS1, TFF1, HGF, FGF2
28histamine46 30 2510.3HGF, PTGER2, ODC1, HRH2, CCKBR
29genistein46 30 62 3 25 1213.3HGF, FGF2, ODC1, PTGS1, TFF1
30estradiol46 25 1210.2TFF1, CYP2C19, NUDT6, CCKBR, HGF
31cycloheximide468.2TFF1, HGF, ODC1, FGF2, PTGS1
32adenylate468.2ODC1, HRH2, HGF, CCKBR, PTGER2
33testosterone46 62 25 1211.2ODC1, HGF, TFF1, NUDT6, CYP2C19
34sb 20358046 629.2ODC1, CCKBR, HGF, FGF2
35h2o2468.2FGF2, HGF, TFF1, PTGS1, ODC1
36vegf468.2PTGER2, NUDT6, PTGS1, HGF, FGF2, TFF1
37aspirin46 52 30 2511.1PTGER2, PTGS1, ODC1, TFF1, HRH2, HGF
38bromodeoxyuridine468.1FGF2, HGF, ODC1, NUDT6, PTGER2, TFF1
39pge2468.1ODC1, FGF2, HRH2, HGF, PTGS1, PTGER2
40dexamethasone46 52 30 1211.0TFF1, CYP2C19, PTGER2, HGF, FGF2, PTGS1
41nitric oxide46 25 129.9PTGS1, CYP2C19, HRH2, ODC1, CCKBR, NUDT6
42glutamate467.8PTGER2, NUDT6, ODC1, CCKBR, HGF, PTGS1
43arginine467.8ODC1, TFF1, NUDT6, HGF, CCKBR
44phosphatidylinositol467.8CCKBR, HGF, FGF2, PTGER2, NUDT6
45estrogen467.7PTGS1, FGF2, HGF, CYP2C19, ODC1, TFF1
46retinoic acid46 258.6FGF2, NUDT6, HRH2, TFF1, HGF, ODC1
47thymidine46 258.5TFF1, CCKBR, FGF2, NUDT6, ODC1, HGF
48nmda46 308.4HGF, FGF2, CCKBR, ODC1, PTGS1, PTGER2
49tyrosine467.2CYP2C19, NUDT6, FGF2, HGF, CCKBR, ODC1
50serine467.1PTGER2, FGF2, HRH2, HGF, CCKBR, PTGS1

GO Terms for genes affiliated with Gastric Ulcer

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17Gene Ontology
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Biological processes related to Gastric Ulcer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1gland developmentGO:0487329.7HRH2, CCKBR
2digestive tract developmentGO:0485659.6HRH2, CCKBR
3arachidonic acid metabolic processGO:0193699.4CYP2C19, PTGS1
4positive chemotaxisGO:0509189.2FGF2, HGF
5positive regulation of osteoblast differentiationGO:0456699.2FGF2, HGF
6digestionGO:0075869.2CCKBR, TFF1

Molecular functions related to Gastric Ulcer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemoattractant activityGO:0420569.2FGF2, HGF
2growth factor activityGO:0080838.2FGF2, HGF, NUDT6, TFF1

Products for genes affiliated with Gastric Ulcer

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  • Antibodies
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  • Antibodies

Sources for Gastric Ulcer

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet