MCID: GST030
MIFTS: 46

Gastrinoma malady

Gastrointestinal diseases, Cancer diseases categories

Summaries for Gastrinoma

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Wikipedia:65 A gastrinoma is a tumor in the pancreas or duodenum that secretes excess of gastrin leading to... more...

MalaCards based summary: Gastrinoma, also known as gastrin secreting tumor, is related to zollinger-ellison syndrome and insulinoma. An important gene associated with Gastrinoma is SCT (secretin), and among its related pathways are G alpha (s) signalling events and Neuropeptides signaling through G protein alpha i and G protein alpha q. The compounds loxiglumide and omeprazole have been mentioned in the context of this disorder. Affiliated tissues include pancreas, small intestine and lymph node, and related mouse phenotype homeostasis/metabolism.

Disease Ontology:10 A neuroendocrine tumor that results in an overproduction of gastric acid.

Aliases & Classifications for Gastrinoma

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Sources:
10Disease Ontology, 12DISEASES, 45Novoseek, 62UMLS, 40NCIt, 57SNOMED-CT, 35MeSH
See all sources

Gastrinoma, Aliases & Descriptions:

Name: Gastrinoma 10 12 45 62
Gastrin Secreting Tumor 10 62
Gastrinoma, Malignant 62
 
Malignant Gastrinoma 10
Gastrin Cell Tumour 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology10 DOID:5577
NCIt40 C3050
MeSH35 D015408

Related Diseases for Gastrinoma

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Diseases related to Gastrinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1zollinger-ellison syndrome31.3SCT, MEN1
2insulinoma30.6SSTR5, SCT, IAPP, MEN1
3neuroendocrine tumor30.5CCKBR, MEN1, SCT
4gastritis30.3CCKBR, SCT
5glucagonoma30.3MEN1, SSTR5, SCT
6atrophic gastritis30.2MEN1, SCT
7adenocarcinoma30.1MEN1, CCKBR, SCT, IAPP
8hyperparathyroidism30.0SCT, MEN1
9islet cell tumor30.0MEN1, IAPP
10prolactinoma30.0SSTR5, MEN1
11multiple endocrine neoplasia 129.9MEN1, PYGM
12duodenitis10.7
13multiple endocrine neoplasia10.7
14duodenal gastrinoma10.7
15pancreatitis10.6
16hepatitis10.6
17pancreatic gastrinoma10.5
18gastric gastrinoma10.3
19cushing's syndrome10.3
20diarrhea10.2
21duodenal ulcer10.1
22esophagitis10.1
23vipoma10.0SCT, MEN1
24primary hyperparathyroidism10.0MEN1, SCT
25gastrointestinal system disease10.0SCT, CCKBR
26cholangiocarcinoma10.0CCKBR, SCT
27acute pancreatitis10.0IAPP, SCT
28alcohol dependence10.0CCKBR, SCT
29acromegaly10.0SSTR5, MEN1
30hypoglycemia10.0SCT, IAPP
31pituitary tumors10.0SSTR5, MEN1
32pancreatic cancer10.0SCT, CCKBR
33hyperinsulinism10.0SCT, IAPP
34hypercalcemia10.0SCT, IAPP, MEN1
35pituitary adenoma10.0SSTR5, MEN1
36lung benign neoplasm10.0NMB, MEN1
37meningioma, familial10.0CCKBR, MEN1, SSTR5
38adenoma10.0SCT, SSTR5, MEN1
39hepatocellular carcinoma10.0SCT, MEN1, CCKBR
40diabetes mellitus, insulin-dependent10.0SCT, IAPP
41obesity10.0IAPP, CCKBR, NMB
42colorectal cancer10.0CCKBR, NMB, IAPP
43primary hyperoxaluria10.0IAPP, SCT, PYGM
44hyperglycemia10.0SCT, IAPP, PYGM
45small cell cancer of the lung, somatic10.0NMB, CCKBR, MEN1, SCT
46pheochromocytoma10.0MEN1, SCT, IAPP, SSTR5
47medullary thyroid carcinoma, familial10.0SSTR5, CCKBR, MEN1, IAPP
48gastrointestinal stromal tumor10.0
49insulin-like growth factor i10.0
50neurofibromatosis, type 210.0

Graphical network of the top 20 diseases related to Gastrinoma:



Diseases related to gastrinoma

Symptoms for Gastrinoma

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Drugs & Therapeutics for Gastrinoma

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Drug clinical trials:

Search ClinicalTrials for Gastrinoma

Search NIH Clinical Center for Gastrinoma

Genetic Tests for Gastrinoma

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Anatomical Context for Gastrinoma

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MalaCards organs/tissues related to Gastrinoma:

33
Pancreas, Small intestine, Lymph node, Liver, Testes, Bone, Pancreatic islet, Spleen, Colon

Animal Models for Gastrinoma or affiliated genes

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MGI Mouse Phenotypes related to Gastrinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.1CCKBR, MEN1, SSTR5, IAPP, SCT

Publications for Gastrinoma

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Articles related to Gastrinoma:

(show top 50)    (show all 397)
idTitleAuthorsYear
1
An evaluation of chromogranin A versus gastrin and progastrin in gastrinoma diagnosis and control. (24796622)
2014
2
Primary lymph node gastrinoma. A diagnosis of exclusion. A case for duodenotomy in the setting of a negative imaging for primary tumor: A case report and review of the literature. (25462049)
2014
3
Partial pancreaticoduodenectomy can provide cure for duodenal gastrinoma associated with multiple endocrine neoplasia type 1. (22580937)
2013
4
Duodenal gastrinoma with multiple gastric neuroendocrine tumors secondary to chronic Helicobacter pylori gastritis. (22588069)
2012
5
Biochemically curative surgery for gastrinoma in multiple endocrine neoplasia type 1 patients. (21455335)
2011
6
Somatostatin Receptor Scintigraphy Findings in a Patient with Metastatic Gastrinoma and MEN 1 Syndrome. (23487241)
2011
7
A case of recurrent gastrinoma in the liver with a review of "primary" hepatic gastrinomas. (21686999)
2009
8
Insulinoma and gastrinoma syndromes from a single intrapancreatic neuroendocrine tumor. (18252785)
2008
9
Hyperplastic polyposis and cancer of the colon with gastrinoma of the duodenum. (16683006)
2006
10
Assessment of the risk of iatrogenic hypergastrinaemia from patients with gastrinoma. (16433885)
2006
11
50-year appraisal of gastrinoma: recommendations for staging and treatment. (16735203)
2006
12
Gastrin-17 specific antibodies are too specific for gastrinoma diagnosis but stain G-cells. (16036513)
2005
13
The diagnosis and treatment of insulinoma and gastrinoma]. (15045936)
2004
14
Primary lymph node gastrinoma: a case report. (12760612)
2003
15
Her-2/neu expression and gene amplification in gastrinomas: correlations with tumor biology, growth, and aggressiveness. (12097278)
2002
16
Gastric collision between a papillotubular adenocarcinoma and a gastrinoma in a patient with Zollinger-Ellison syndrome. (12447676)
2002
17
Somatostatin scan positive gastrinoma ocular metastasis. (10636690)
1999
18
Surgical resection of intracardiac gastrinoma. (10197684)
1999
19
The origin of sporadic gastrinomas within the gastrinoma triangle: a theory. (9438752)
1998
20
Octreotide scintigraphy: a prerequisite for liver transplantation for metastatic gastrinoma. (9623469)
1998
21
Distinguishing small hepatic hemangiomas from vascular liver metastases in gastrinoma: use of a somatostatin-receptor scintigraphic agent. (8988205)
1997
22
Gastrinoma: a retrospective study of four cases (1985-1995). (9358421)
1997
23
Gastrinoma before Zollinger and Ellison. (9324128)
1997
24
Is gastrinoma a medical disease? (9165698)
1996
25
Prospective study of surgical resection of duodenal and pancreatic gastrinomas in multiple endocrine neoplasia type 1. (7491542)
1995
26
Somatostatin receptor scintigraphy in neuroendocrine tumors exemplified by a patient with hepatic metastases of gastrinoma]. (7513113)
1994
27
Gastrinomas demonstrate amplification of the HER-2/neu proto-oncogene. (7911296)
1994
28
Surgery in Zollinger-Ellison syndrome alters the natural history of gastrinoma. (7916560)
1994
29
Duodenal gastrinoma: the solution to the pancreatic paradox. (7806825)
1994
30
Detection of occult gastrinomas with iodine 125-labeled lanreotide and intraoperative gamma detection. (7985099)
1994
31
An evaluation of human recombinant alpha interferon in patients with metastatic gastrinoma. (8405864)
1993
32
Biologic and immunologic gastrin activity in serum of patients with gastrinoma. Bioassay of gastrin activity in serum. (1475620)
1992
33
Effects of curative gastrinoma resection on gastric secretory function and antisecretory drug requirement in the Zollinger-Ellison syndrome. (1537514)
1992
34
Intraocular transplants of a human gastrinoma in immuno-suppressed rats: morphological, chromatographic and functional studies. (2740530)
1989
35
Gastrinoma. New medical and surgical approaches. (2567061)
1989
36
Gastrinoma (Zollinger-Ellison Syndrome) in the Dog and cat. (17423047)
1988
37
Distribution, molecular forms, and bioactivity of immunoreactive gastrin in a patient with metastatic gastrinoma. (3631036)
1987
38
Prospective study of the ability of computed axial tomography to localize gastrinomas in patients with Zollinger-Ellison syndrome. (3556996)
1987
39
Ectopic gastrinoma and Zollinger-Ellison syndrome. (3710471)
1986
40
Aggressive resection of metastatic disease in selected patients with malignant gastrinoma. (2938550)
1986
41
Case 3. Renal gastrinoma with Zollinger-Ellison syndrome. (3588443)
1986
42
Synergistic interaction between an H2-receptor antagonist and enprostil on 24-hour intragastric pH, serum gastrin concentration, and tissue immunoperoxidase staining for gastrin, somatostatin, and serotonin in a patient with metastatic gastrinoma. (2878726)
1986
43
Gastrinoma: factors influencing prognosis. (2857058)
1985
44
Endoscopic diagnosis and removal of a duodenal wall gastrinoma. (6475895)
1984
45
Thirty years' experience with gastrinoma. (6148806)
1984
46
Diagnosis and management of gastrinoma (Zollinger-Ellison Syndrome) (7070121)
1982
47
Laboratory diagnosis of gastrinoma. I. A prospective evaluation of gastric analysis and fasting serum gastrin levels. (7070117)
1982
48
Diagnosis of gastrinoma by the secretin suppression test. (982259)
1976
49
Proceedings: Malignant gastrinoma following total gastrectomy. (4273862)
1974
50
Antor-pyloric gastrinoma associated with pancreatic nesidioblastosis and proliferation of islets. (4201098)
1973

Variations for Gastrinoma

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Cosmic variations for Gastrinoma:

8
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
122579MEN1small intestine,duodenum,carcinoid-endocrine tumour,gastrinoma1

Expression for genes affiliated with Gastrinoma

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Search GEO for disease gene expression data for Gastrinoma.

Pathways for genes affiliated with Gastrinoma

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Compounds for genes affiliated with Gastrinoma

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Compounds related to Gastrinoma according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
1loxiglumide4510.0CCKBR, SCT
2omeprazole45 51 30 26 1313.9SCT, CCKBR
3tetrodotoxin45 61 3011.8SCT, CCKBR
4c-peptide459.8IAPP, SCT
5dtpa459.8CCKBR, NMB
6amphetamine45 51 1311.7CCKBR, IAPP
7opiate459.6NMB, IAPP
8ibmx45 61 3011.6IAPP, SCT
9amide459.5CCKBR, IAPP
10catecholamine459.5SCT, IAPP
11histamine45 30 2611.4CCKBR, IAPP, SCT
12octreotide45 61 30 1312.4CCKBR, SSTR5, SCT
13estradiol45 26 1311.4CCKBR, IAPP, SCT
14acth459.3CCKBR, SSTR5, SCT
15adenylate459.2CCKBR, IAPP, SCT
16cocaine45 1310.2CCKBR, IAPP
17acetylcholine45 51 30 26 1313.0SCT, IAPP, CCKBR, NMB
18dopamine45 30 26 1311.8SCT, IAPP, SSTR5, CCKBR
19serine458.8SCT, IAPP, MEN1, CCKBR
20hydrogen45 269.6NMB, CCKBR, SCT, PYGM
21thymidine45 269.5CCKBR, MEN1, SSTR5, IAPP, SCT
22arginine458.1PYGM, SCT, IAPP, CCKBR, NMB
23tyrosine458.1PYGM, SCT, SSTR5, MEN1, CCKBR
24calcium45 51 26 1310.9SCT, IAPP, SSTR5, MEN1, CCKBR, NMB

GO Terms for genes affiliated with Gastrinoma

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Biological processes related to Gastrinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cytosolic calcium ion concentrationGO:00072049.5NMB, CCKBR
2glucose homeostasisGO:00425939.0NMB, SSTR5

Molecular functions related to Gastrinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051799.1NMB, IAPP, SCT

Products for genes affiliated with Gastrinoma

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Sources for Gastrinoma

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet