MCID: GST030
MIFTS: 46

Gastrinoma malady

Gastrointestinal diseases, Cancer diseases categories

Summaries for Gastrinoma

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66Wikipedia, 34MalaCards
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Wikipedia:66 A gastrinoma is a tumor in the pancreas or duodenum that secretes excess of gastrin leading to... more...

MalaCards: Gastrinoma, also known as gastrin secreting tumor, is related to zollinger-ellison syndrome and neuroendocrine tumor. An important gene associated with Gastrinoma is SCT (secretin), and among its related pathways are G alpha (s) signalling events and Neuropeptides signaling through G protein alpha i and G protein alpha q. The compounds loxiglumide and omeprazole have been mentioned in the context of this disorder. Affiliated tissues include pancreas, small intestine and liver, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Gastrinoma

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 41NCIt, 59SNOMED-CT, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

gastrinoma 9 11 46 63
gastrin secreting tumor 9
gastrinoma, malignant 63
malignant gastrinoma 9
gastrin cell tumour 9


External Ids:

Disease Ontology9 DOID:5577
NCIt41 C3050
MeSH36 D015408

Related Diseases for Gastrinoma

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18GeneCards, 19GeneDecks
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Diseases related to Gastrinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
1zollinger-ellison syndrome31.4SCT, MEN1
2neuroendocrine tumor30.5CCKBR, MEN1, SCT
3insulinoma30.5SSTR5, SCT, IAPP, MEN1
4gastritis30.3CCKBR, SCT
5glucagonoma30.3MEN1, SSTR5, SCT
6atrophic gastritis30.2MEN1, SCT
7adenocarcinoma30.1MEN1, CCKBR, SCT, IAPP
8hyperparathyroidism30.0SCT, MEN1
9pancreatic islet cell tumors30.0MEN1, IAPP
10prolactinoma30.0SSTR5, MEN1
11wermer syndrome29.9MEN1, PYGM
12duodenitis10.7
13multiple endocrine neoplasia10.7
14duodenal gastrinoma10.6
15pancreatitis10.6
16hepatitis10.6
17pancreatic gastrinoma10.4
18gastric gastrinoma10.2
19cushing's syndrome10.2
20diarrhea10.2
21duodenal ulcer10.1
22vipoma10.1SCT, MEN1
23primary hyperparathyroidism10.1MEN1, SCT
24gastrointestinal system disease10.1SCT, CCKBR
25cholangiocarcinoma10.0CCKBR, SCT
26acute pancreatitis10.0IAPP, SCT
27acromegaly10.0SSTR5, MEN1
28hypoglycemia10.0SCT, IAPP
29pancreatic cancer10.0SCT, CCKBR
30pituitary tumors10.0SSTR5, MEN1
31hyperinsulinism10.0SCT, IAPP
32hypercalcemia10.0SCT, IAPP, MEN1
33pituitary adenoma10.0SSTR5, MEN1
34lung benign neoplasm10.0NMB, MEN1
35meningioma10.0CCKBR, MEN1, SSTR5
36hepatocellular carcinoma10.0SCT, MEN1, CCKBR
37adenoma10.0SCT, SSTR5, MEN1
38type 1 diabetes mellitus10.0SCT, IAPP
39obesity10.0IAPP, CCKBR, NMB
40colon cancer10.0CCKBR, NMB, IAPP
41primary hyperoxaluria10.0IAPP, SCT, PYGM
42hyperglycemia10.0SCT, IAPP, PYGM
43lung small cell carcinoma10.0NMB, CCKBR, MEN1, SCT
44diabetes mellitus10.0IAPP, PYGM, SCT
45pheochromocytoma10.0MEN1, SCT, IAPP, SSTR5
46thyroid medullary carcinoma9.9SSTR5, CCKBR, MEN1, IAPP
47barrett's esophagus9.9
48mixed ductal-endocrine carcinoma9.9
49gastroduodenitis9.9
50somatostatinoma9.9

Graphical network of the top 20 diseases related to Gastrinoma:



Diseases related to gastrinoma

Symptoms for Gastrinoma

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Drugs & Therapeutics for Gastrinoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Gastrinoma

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Anatomical Context for Gastrinoma

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34MalaCards
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MalaCards organs/tissues related to Gastrinoma:

34
Pancreas, Small intestine, Liver, Lymph node, Testes, Bone, Pancreatic islet, Spleen, Colon

Animal Models for Gastrinoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Gastrinoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.1CCKBR, MEN1, SSTR5, IAPP, SCT

Publications for Gastrinoma

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53PubMed
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Articles related to Gastrinoma:

(show top 50)    (show all 385)
idTitleAuthorsYear
1
Partial pancreaticoduodenectomy can provide cure for duodenal gastrinoma associated with multiple endocrine neoplasia type 1. (22580937)
2013
2
Duodenal gastrinoma with multiple gastric neuroendocrine tumors secondary to chronic Helicobacter pylori gastritis. (22588069)
2012
3
Biochemically curative surgery for gastrinoma in multiple endocrine neoplasia type 1 patients. (21455335)
2011
4
Somatostatin Receptor Scintigraphy Findings in a Patient with Metastatic Gastrinoma and MEN 1 Syndrome. (23487241)
2011
5
A case of recurrent gastrinoma in the liver with a review of "primary" hepatic gastrinomas. (21686999)
2009
6
Insulinoma and gastrinoma syndromes from a single intrapancreatic neuroendocrine tumor. (18252785)
2008
7
Hyperplastic polyposis and cancer of the colon with gastrinoma of the duodenum. (16683006)
2006
8
Assessment of the risk of iatrogenic hypergastrinaemia from patients with gastrinoma. (16433885)
2006
9
50-year appraisal of gastrinoma: recommendations for staging and treatment. (16735203)
2006
10
Gastrin-17 specific antibodies are too specific for gastrinoma diagnosis but stain G-cells. (16036513)
2005
11
The diagnosis and treatment of insulinoma and gastrinoma]. (15045936)
2004
12
Primary lymph node gastrinoma: a case report. (12760612)
2003
13
Her-2/neu expression and gene amplification in gastrinomas: correlations with tumor biology, growth, and aggressiveness. (12097278)
2002
14
Gastric collision between a papillotubular adenocarcinoma and a gastrinoma in a patient with Zollinger-Ellison syndrome. (12447676)
2002
15
Somatostatin scan positive gastrinoma ocular metastasis. (10636690)
1999
16
Surgical resection of intracardiac gastrinoma. (10197684)
1999
17
The origin of sporadic gastrinomas within the gastrinoma triangle: a theory. (9438752)
1998
18
Octreotide scintigraphy: a prerequisite for liver transplantation for metastatic gastrinoma. (9623469)
1998
19
Distinguishing small hepatic hemangiomas from vascular liver metastases in gastrinoma: use of a somatostatin-receptor scintigraphic agent. (8988205)
1997
20
Gastrinoma: a retrospective study of four cases (1985-1995). (9358421)
1997
21
Gastrinoma before Zollinger and Ellison. (9324128)
1997
22
A prospective analysis of the frequency, location, and curability of ectopic (nonpancreaticoduodenal, nonnodal) gastrinoma. (9426435)
1997
23
Is gastrinoma a medical disease? (9165698)
1996
24
Prospective study of surgical resection of duodenal and pancreatic gastrinomas in multiple endocrine neoplasia type 1. (7491542)
1995
25
Somatostatin receptor scintigraphy in neuroendocrine tumors exemplified by a patient with hepatic metastases of gastrinoma]. (7513113)
1994
26
Gastrinomas demonstrate amplification of the HER-2/neu proto-oncogene. (7911296)
1994
27
Surgery in Zollinger-Ellison syndrome alters the natural history of gastrinoma. (7916560)
1994
28
Duodenal gastrinoma: the solution to the pancreatic paradox. (7806825)
1994
29
Detection of occult gastrinomas with iodine 125-labeled lanreotide and intraoperative gamma detection. (7985099)
1994
30
An evaluation of human recombinant alpha interferon in patients with metastatic gastrinoma. (8405864)
1993
31
Duodenal gastrinomas, duodenotomy, and duodenal exploration in the surgical management of Zollinger-Ellison syndrome. (8103249)
1993
32
Biologic and immunologic gastrin activity in serum of patients with gastrinoma. Bioassay of gastrin activity in serum. (1475620)
1992
33
Effects of curative gastrinoma resection on gastric secretory function and antisecretory drug requirement in the Zollinger-Ellison syndrome. (1537514)
1992
34
Intraocular transplants of a human gastrinoma in immuno-suppressed rats: morphological, chromatographic and functional studies. (2740530)
1989
35
Gastrinoma. New medical and surgical approaches. (2567061)
1989
36
Gastrinoma (Zollinger-Ellison Syndrome) in the Dog and cat. (17423047)
1988
37
Distribution, molecular forms, and bioactivity of immunoreactive gastrin in a patient with metastatic gastrinoma. (3631036)
1987
38
Prospective study of the ability of computed axial tomography to localize gastrinomas in patients with Zollinger-Ellison syndrome. (3556996)
1987
39
Ectopic gastrinoma and Zollinger-Ellison syndrome. (3710471)
1986
40
Aggressive resection of metastatic disease in selected patients with malignant gastrinoma. (2938550)
1986
41
Case 3. Renal gastrinoma with Zollinger-Ellison syndrome. (3588443)
1986
42
Synergistic interaction between an H2-receptor antagonist and enprostil on 24-hour intragastric pH, serum gastrin concentration, and tissue immunoperoxidase staining for gastrin, somatostatin, and serotonin in a patient with metastatic gastrinoma. (2878726)
1986
43
Gastrinoma: factors influencing prognosis. (2857058)
1985
44
Endoscopic diagnosis and removal of a duodenal wall gastrinoma. (6475895)
1984
45
Thirty years' experience with gastrinoma. (6148806)
1984
46
Diagnosis and management of gastrinoma (Zollinger-Ellison Syndrome) (7070121)
1982
47
Laboratory diagnosis of gastrinoma. I. A prospective evaluation of gastric analysis and fasting serum gastrin levels. (7070117)
1982
48
Diagnosis of gastrinoma by the secretin suppression test. (982259)
1976
49
Proceedings: Malignant gastrinoma following total gastrectomy. (4273862)
1974
50
Antor-pyloric gastrinoma associated with pancreatic nesidioblastosis and proliferation of islets. (4201098)
1973

Variations for Gastrinoma

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Expression for genes affiliated with Gastrinoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gastrinoma

Search GEO for disease gene expression data for Gastrinoma.

Pathways for genes affiliated with Gastrinoma

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51PathCards, 56Reactome, 13EMD Millipore, 39NCBI BioSystems Database, 31KEGG
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Compounds for genes affiliated with Gastrinoma

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46Novoseek, 52PharmGKB, 30IUPHAR, 25HMDB, 12DrugBank, 62Tocris Bioscience
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Compounds related to Gastrinoma according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
1loxiglumide4610.0CCKBR, SCT
2omeprazole46 52 30 25 1213.9SCT, CCKBR
3tetrodotoxin46 62 3011.8SCT, CCKBR
4c-peptide469.8IAPP, SCT
5dtpa469.8CCKBR, NMB
6amphetamine46 52 1211.7CCKBR, IAPP
7opiate469.6NMB, IAPP
8ibmx46 62 3011.6IAPP, SCT
9amide469.5CCKBR, IAPP
10catecholamine469.5SCT, IAPP
11histamine46 30 2511.4CCKBR, IAPP, SCT
12octreotide46 62 30 1212.4CCKBR, SSTR5, SCT
13estradiol46 25 1211.4CCKBR, IAPP, SCT
14acth469.3CCKBR, SSTR5, SCT
15adenylate469.2CCKBR, IAPP, SCT
16cocaine46 1210.2CCKBR, IAPP
17acetylcholine46 52 30 25 1213.0SCT, IAPP, CCKBR, NMB
18dopamine46 30 25 1211.8SCT, IAPP, SSTR5, CCKBR
19serine468.8SCT, IAPP, MEN1, CCKBR
20hydrogen46 259.6NMB, CCKBR, SCT, PYGM
21thymidine46 259.5CCKBR, MEN1, SSTR5, IAPP, SCT
22arginine468.1PYGM, SCT, IAPP, CCKBR, NMB
23tyrosine468.1PYGM, SCT, SSTR5, MEN1, CCKBR
24calcium46 52 25 1210.9SCT, IAPP, SSTR5, MEN1, CCKBR, NMB

GO Terms for genes affiliated with Gastrinoma

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17Gene Ontology
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Biological processes related to Gastrinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cytosolic calcium ion concentrationGO:0072049.5NMB, CCKBR
2glucose homeostasisGO:0425939.0NMB, SSTR5

Molecular functions related to Gastrinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.1NMB, IAPP, SCT

Products for genes affiliated with Gastrinoma

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  • Antibodies
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Sources for Gastrinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet