MCID: GST030
MIFTS: 51

Gastrinoma malady

Gastrointestinal, Cancer categories

Summaries for Gastrinoma

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64Wikipedia, 33MalaCards
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Wikipedia:64 A gastrinoma is a tumor in the pancreas or duodenum that secretes excess of gastrin leading to... more...

MalaCards: Gastrinoma, also known as gastrin secreting tumor, is related to zollinger-ellison syndrome and multiple endocrine neoplasia. An important gene associated with Gastrinoma is SCT (secretin), and among its related pathways are Gastric acid secretion and G alpha (q) signalling events. The compounds forskolin and pasireotide have been mentioned in the context of this disorder. Affiliated tissues include lymph node, spleen and small intestine, and related mouse phenotypes are digestive/alimentary and immune system.

Aliases & Classifications for Gastrinoma

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Gastrointestinal


Aliases & Descriptions:

gastrinoma 8 10 45 61
gastrin secreting tumor 8
gastrinoma, malignant 61
malignant gastrinoma 8
gastrin cell tumour 8


External Ids:

Disease Ontology8 DOID:5577
MeSH35 D015408
NCIt40 C3050

Related Diseases for Gastrinoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Gastrinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 122)
idRelated DiseaseScoreTop Affiliating Genes
1zollinger-ellison syndrome31.2SCT, GAST, MEN1, CHGA, GRP, SST
2multiple endocrine neoplasia31.0CHGA, MEN1, GAST, VIP
3pancreatic gastrinoma30.9PPP2R5B
4insulinoma30.5VIP, PDX1, GLP1R, SST, SSTR1, SCT
5carcinoid syndrome30.4VIP, CCKBR, SCT, GAST, MEN1, SYP
6cushing's syndrome30.4MEN1, SYP, CHGA, SST
7glucagonoma30.2CHGA, SSTR5, SSTR2, SST, MEN1, GAST
8duodenal ulcer30.1SCT, GAST, GRP
9atrophic gastritis30.1SCT, GAST, MEN1, CHGA, SST
10gastric ulcer30.1GAST, CCKBR
11adenocarcinoma30.1VIP, CCKBR, PDX1, SST, SSTR1, SSTR2
12pernicious anemia29.9GAST
13phaeochromocytoma29.9CHGA
14apudoma29.9SST
15somatostatinoma29.9VIP, GAST, CHGA, SSTR2, SST
16pancreatitis, chronic29.9SST, GRP, SCT
17wermer syndrome29.9PYGM, SCT, GAST, MEN1, CHGA, SST
18prolactinoma29.9MEN1, CHGA, SSTR5, SSTR2, SSTR1, SST
19pancreatic islet cell tumors29.9VIP, GAST, MEN1, SYP, CHGA, IAPP
20duodenal gastrinoma10.7
21gastric gastrinoma10.6
22n syndrome10.5
23somatostatin analog10.3
24duodenitis10.0GAST
25von hippel-lindau disease10.0MEN1
26esophagitis10.0GAST
27gastroduodenitis10.0GAST
28duodenum cancer10.0SST
29esophageal atresia10.0SHH
30cholelithiasis10.0SST
31hirschsprung's disease10.0VIP
32carney complex10.0MEN1
33pancreatitis10.0SCT, SST
34parkinson's disease10.0SHH
35gigantism10.0SST
36constipation10.0VIP
37hyperinsulinemic hypoglycemia10.0SST, GAST
38hemangioma10.0MEN1
39parathyroid adenoma10.0CHGA, MEN1
40dyspepsia10.0GAST
41neuroblastoma10.0SYP, VIP
42glioblastoma multiforme10.0GRP, CCKBR
43peptic ulcer10.0SCT, GAST, SST
44pancreas disease10.0SCTR, SCT, GAST
45ganglioneuroblastoma10.0VIP, SYP
46merkel cell carcinoma10.0CHGA, SYP
47dementia10.0GRP, SYP
48sarcoma10.0SSTR2
49angiodysplasia10.0SST
50cholangiocarcinoma10.0SCT, CCKBR

Graphical network of the top 20 diseases related to Gastrinoma:



Diseases related to gastrinoma

Clinical Features for Gastrinoma

Drugs & Therapeutics for Gastrinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Gastrinoma

Drug clinical trials:

Search ClinicalTrials for Gastrinoma

Search NIH Clinical Center for Gastrinoma

Search CenterWatch for Gastrinoma

Genetic Tests for Gastrinoma

Anatomical Context for Gastrinoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Gastrinoma:

33
Lymph node, Spleen, Small intestine, Colon, Liver, Pancreas, B cells, Pancreatic islet

Animal Models for Gastrinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Gastrinoma

Sources:
51PubMed
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Articles related to Gastrinoma:

(show top 50)    (show all 390)
idTitleAuthorsYear
1
Visual vignette. Gastrinoma. (21940272)
2012
2
Diagnosis and Treatment of Gastrinomas in Multiple Endocrine Neoplasia Type 1 (MEN-1). (24213225)
2012
3
Biochemically curative surgery for gastrinoma in multiple endocrine neoplasia type 1 patients. (21455335)
2011
4
Long-term follow-up of a child with primary lymph node gastrinoma and Zollinger-Ellison syndrome. (21616263)
2011
5
Mechanism of acid hypersecretion post curative gastrinoma resection. (20725788)
2011
6
Gastrinoma in childhood: case report and update on diagnosis and treatment. (19221952)
2009
7
Insulinoma and gastrinoma syndromes from a single intrapancreatic neuroendocrine tumor. (18252785)
2008
8
Curative resection of primary hepatic gastrinoma. (19260510)
2008
9
Management of sporadic and multiple endocrine neoplasia type 1 gastrinomas. (17939142)
2007
10
Surgical treatment of sporadic gastrinoma. (17985095)
2007
11
Hyperplastic polyposis and cancer of the colon with gastrinoma of the duodenum. (16683006)
2006
12
Canine gastrinoma: a case study and literature review of therapeutic options. (17028663)
2006
13
Increased islet beta cell replication adjacent to intrapancreatic gastrinomas in humans. (17016695)
2006
14
Surgery and prognosis of duodenal gastrinoma as a duodenal neuroendocrine tumor. (16253894)
2005
15
Zollinger-Ellison syndrome caused by solitary gastrinoma blocking the pancreatic duct: enucleation and pancreatic duct repair. (16003327)
2005
16
Regression of type II gastric carcinoids in multiple endocrine neoplasia type 1 patients with Zollinger-Ellison syndrome after surgical excision of all gastrinomas. (15383867)
2004
17
Prospective study of the ability of serial measurements of serum chromogranin A and gastrin to detect changes in tumor burden in patients with gastrinomas. (12872342)
2003
18
Ovarian gastrinoma in multiple endocrine neoplasia type I: a case report. (11174512)
2001
19
Visual vignette. Metastatic gastrinoma. (12940238)
2001
20
Primary nodal gastrinomas. (10835515)
2000
21
Mixed ductal-endocrine carcinoma of the pancreas presenting as gastrinoma with Zollinger-Ellison syndrome: an autopsy case with a 24-year survival period. (10628803)
1999
22
Cushing's syndrome due to ectopic adrenocorticotropic hormone production by a non-metastatic gastrinoma after long-term conservative treatment of Zollinger-Ellison syndrome. (10076790)
1998
23
Response to treatment with yttrium 90-DOTA-lanreotide of a patient with metastatic gastrinoma. (9867148)
1998
24
Duodenal gastrinoma--clinical features and usefulness of selective arterial secretin injection test. (9773940)
1998
25
Quick radioimmunoassay for plasma immunoreactive gastrin--application for localizing occult gastrinoma(s) during operation]. (8676568)
1996
26
Forty-year appraisal of gastrinoma. Back to the future. (7574931)
1995
27
Somatostatin receptor scintigraphy in neuroendocrine tumors exemplified by a patient with hepatic metastases of gastrinoma]. (7513113)
1994
28
Zollinger-Ellison syndrome. Advances in treatment of gastric hypersecretion and the gastrinoma. (7513768)
1994
29
Ultrastructural and immunocytochemical study of a primary gastrinoma of the liver. (1448886)
1992
30
Surgical pathology of gastrinoma. Site, size, multicentricity, association with multiple endocrine neoplasia type 1, and malignancy. (1678681)
1991
31
Gastrinoma. (2180046)
1990
32
Endoscopic diagnosis and treatment of duodenal gastrinoma. (2227329)
1990
33
Intraarterial secretin injection for gastrinoma localization. (2294577)
1990
34
Effects of neuromedin B and GRP-10 on gastrin and insulin release from cultured tumor cells of a malignant gastrinoma. (2101791)
1990
35
Gastrin in non-neoplastic pancreatic tissue from patients with and without gastrinomas. (2218398)
1990
36
Extrapancreatic gastrinoma with pancreatic islet cell hyperplasia. (2653274)
1989
37
Zollinger-Ellison syndrome, duodenal carcinoid (gastrinoma), and hyperthyroidism. (2508315)
1989
38
A prospective study of perioperative and postoperative control of acid hypersecretion in patients with Zollinger-Ellison syndrome undergoing gastrinoma resection. (2904182)
1988
39
Isolation and characterization of the intact gastrin precursor from a gastrinoma. (3792562)
1987
40
Case 3. Renal gastrinoma with Zollinger-Ellison syndrome. (3588443)
1986
41
Characterization of the in vivo and in vitro inhibition of gastrin secretion from gastrinoma by a somatostatin analogue (SMS 201-995). (2879448)
1986
42
Current approach to the management of tumoral process in patients with gastrinoma. (2875567)
1986
43
Prospective study of gastrinoma localization and resection in patients with Zollinger-Ellison syndrome. (3532971)
1986
44
Sensitivity, specificity and predictive values of the secretin infusion test in the diagnosis of gastrinoma. (3758593)
1986
45
The gastrinoma triangle: operative implications. (6691547)
1984
46
Comparison of four provocative tests for the diagnosis of gastrinoma. (6847280)
1983
47
A unique apudoma producing the glucagonoma and gastrinoma syndromes. (6878103)
1983
48
Diagnosis and management of gastrinoma (Zollinger-Ellison Syndrome) (7070121)
1982
49
Laboratory diagnosis of gastrinoma. II. A prospective study of gastrin challenge tests. (7040824)
1982
50
Gastrinoma and phaeochromocytoma: is there a mixed multiple endocrine adneoma syndrome? (6101928)
1980

Genetic Variations for Gastrinoma

Expression for genes affiliated with Gastrinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gastrinoma

Search GEO for disease gene expression data for Gastrinoma.

Pathways for genes affiliated with Gastrinoma

Sources:
30KEGG, 54Reactome, 12EMD Millipore, 38NCBI BioSystems Database
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Compounds for genes affiliated with Gastrinoma

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 24HMDB, 29IUPHAR
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Compounds related to Gastrinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 182)
idCompoundScoreTop Affiliating Genes
1forskolin45 50 1112.5SCT, SSTR2, PDX1
2pasireotide45 1111.4SSTR1, SST, SSTR2, SSTR5
3(1r,1s,3r/1r,1r,3s)-l-054,2646010.4SSTR5, SST, SSTR1, SSTR2
4cyclosomatostatin6010.4SSTR5, SSTR2, SSTR1, SST
5cyn 1548066010.4SSTR1, SST, SSTR5, SSTR2
6somatostatin60 2411.4SSTR5, SSTR2, SSTR1, SST
7tyr-3-octreotide4510.4SST, SSTR2, VIP
8atropine45 29 1112.3GRP, SCT, GAST
9pepsinogen4510.3GAST, CHGA, GRP, SCT
10som-2302910.3SSTR5, SSTR2, SSTR1
11lanreotide45 2911.3SSTR5, SSTR2, SSTR1, SST, CHGA
12loxiglumide4510.3SST, GRP, GAST, SCT, CCKBR
13omeprazole45 29 50 11 2414.3SCT, GAST, CHGA, CCKBR, SST
14minigastrin4510.3SST, GRP, GAST, CCKBR, VIP
15cst-172910.2SSTR1, SSTR2, SSTR5
16111in-pentetreotide4510.2SSTR1, SSTR2, SSTR5, CHGA, SYP, SST
175-hydroxyindoleacetic acid45 2411.2VIP, GAST, CHGA, SST
18streptozotocin4510.2SYP, SST, IAPP, CHGA, PDX1
19bim 230522910.2SSTR1, SSTR2, SSTR5
20dtpa4510.2GAST, CCKBR, SST, SSTR2, GRP, NMB
21propranolol45 29 50 11 2414.1VIP, GRP, CHGA, GAST, SCT, SST
22cgp 239962910.1SSTR1, SSTR2, SSTR5
23bim 236272910.1SSTR1, SSTR5, SSTR2
24c-peptide4510.1GLP1R, CHGA, PDX1, SCT, GAST, IAPP
25oxyntomodulin45 6011.0GRP, CHGA, GAST, SCT, VIP, GLP1R
26carbachol45 29 1112.0CHGA, GRP, SST, GAST, VIP, SCT
27guanine45 11 2412.0CHGA, VIP, SSTR2, GRP, CCKBR, SCT
28ke 1082910.0SSTR1, SSTR2, SSTR5
295-hydroxytryptamine4510.0GAST, SYP, CHGA, SST, VIP, GRP
30isoproterenol45 1111.0SST, GRP, CHGA, GAST, SCT, VIP
31glucose459.9PYGM, GLP1R, SSTR2, GAST, SCT, PDX1
32gaba459.9SYP, SCT, GAST, CHGA, GRP, SST
33epinephrine45 11 2411.9CHGA, GAST, GRP, VIP, SCT, SST
34gnrh459.9SSTR2, VIP, GAST, CHGA, GRP, SST
35norepinephrine45 11 2411.8GRP, IAPP, SST, CHGA, SYP, GAST
36[125i]cgp 23996299.8SSTR5, SSTR2, SSTR1
37acth459.7GRP, CHGA, SYP, GAST, SCT, CCKBR
38octreotide45 60 29 1112.7SST, SSTR2, GRP, SSTR5, VIP, CCKBR
39thymidine45 2410.7SSTR5, VIP, CCKBR, PDX1, SCT, GAST
40histamine45 29 2411.7VIP, CCKBR, SCT, GAST, CHGA, SSTR2
41dopamine45 29 11 2412.7VIP, CCKBR, SCT, GAST, CHGA, GRP
42arginine459.7PYGM, CCKBR, SCT, VIP, CHGA, NMB
43vegf459.7SSTR2, GRP, CHGA, SYP, GAST, MEN1
44cyclic amp45 2410.6SCT, GLP1R, SSTR1, IAPP, GRP, CHGA
45testosterone45 60 11 2412.6IAPP, VIP, SCT, GAST, SYP, GRP
46acetylcholine45 50 29 11 2413.5CHGA, VIP, CCKBR, NMB, SCTR, SST
47adenylate459.4GRP, VIP, SST, SSTR1, CHGA, SSTR2
48serine459.4GRP, CHGA, SYP, VIP, PDX1, CCKBR
49tyrosine459.3MEN1, SCT, GAST, SYP, CHGA, SSTR2
50calcium45 50 11 2411.9SSTR1, NMB, GLP1R, SSTR2, SSTR5, IAPP

GO Terms for genes affiliated with Gastrinoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Gastrinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.5NMB, SST, IAPP, GRP, CHGA, GAST

Biological processes related to Gastrinoma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00718710.3SSTR5, SSTR2, SSTR1
2cellular response to estradiol stimulusGO:07139210.2SSTR1, SSTR2
3forebrain developmentGO:03090010.2SSTR1, SSTR2, SHH
4response to nutrientGO:00758410.1SSTR2, SSTR1, SST
5digestionGO:00758610.1SST, SSTR1, SSTR2, SCTR, CCKBR
6glucose homeostasisGO:04259310.1NMB, SSTR5, PDX1
7positive regulation of cell proliferationGO:00828410.0VIP, CCKBR, PDX1, SHH, NMB
8negative regulation of cell proliferationGO:00828510.0PDX1, MEN1, SSTR5, SSTR2, SSTR1, SST
9G-protein coupled receptor signaling pathwayGO:00718610.0SST, SSTR5, GAST, SCTR, VIP
10cell-cell signalingGO:00726710.0SHH, IAPP, SSTR2, SSTR1, SST, NMB
11elevation of cytosolic calcium ion concentrationGO:0072049.8NMB, GLP1R, CCKBR

Molecular functions related to Gastrinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1somatostatin receptor activityGO:00499410.1SSTR1, SSTR2, SSTR5
2hormone activityGO:0051799.5NMB, SST, IAPP, GAST, SCT, VIP

Products for genes affiliated with Gastrinoma

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Sources for Gastrinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet