MCID: GST030
MIFTS: 55

Gastrinoma malady

Gastrointestinal diseases, Cancer diseases categories

Summaries for Gastrinoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 A gastrinoma is a tumor in the pancreas or duodenum that secretes excess of gastrin leading to... more...

MalaCards: Gastrinoma, also known as gastrin secreting tumor, is related to zollinger-ellison syndrome and duodenitis. An important gene associated with Gastrinoma is SCT (secretin), and among its related pathways are Gastric acid secretion and G alpha (q) signalling events. The compounds forskolin and pasireotide have been mentioned in the context of this disorder. Affiliated tissues include pancreas, small intestine and liver, and related mouse phenotypes are digestive/alimentary and immune system.

Aliases & Classifications for Gastrinoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

gastrinoma 8 10 44 60
gastrin secreting tumor 8
gastrinoma, malignant 60
malignant gastrinoma 8
gastrin cell tumour 8


External Ids:

Disease Ontology8 DOID:5577
MeSH34 D015408
NCIt39 C3050

Related Diseases for Gastrinoma

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17GeneCards, 18GeneDecks
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Diseases related to Gastrinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1zollinger-ellison syndrome31.2SCT, GAST, MEN1, CHGA, GRP, SST
2duodenitis31.0GAST
3pancreatic gastrinoma30.9PPP2R5B
4pancreatitis30.8SCT, SST
5insulinoma30.5VIP, PDX1, GLP1R, SST, SSTR1, SCT
6neuroendocrine tumor30.4VIP, CHGA, SSTR2, SST
7cushing's syndrome30.3MEN1, SYP, CHGA, SST
8diarrhea30.2SST, CHGA, GAST, VIP
9gastritis30.2CCKBR, SCT, GAST, CHGA, SST
10peptic ulcer30.0SCT, GAST, SST
11duodenal ulcer30.0SCT, GAST, GRP
12atrophic gastritis30.0SCT, GAST, MEN1, CHGA, SST
13gastric ulcer30.0GAST, CCKBR
14gastric adenocarcinoma30.0VIP, CCKBR, GAST, CHGA, GRP, SSTR2
15adenocarcinoma30.0VIP, CCKBR, PDX1, SST, SSTR1, SSTR2
16esophagitis29.8GAST
17gastroduodenitis29.8GAST
18pernicious anemia29.8GAST
19phaeochromocytoma29.8CHGA
20hemangioma29.8MEN1
21islet cell tumor29.8GAST, SST
22hyperparathyroidism29.8SCT, GAST, MEN1, CHGA
23somatostatinoma29.8VIP, GAST, CHGA, SSTR2, SST
24wermer syndrome29.8PYGM, SCT, GAST, MEN1, CHGA, SST
25prolactinoma29.8MEN1, CHGA, SSTR5, SSTR2, SSTR1, SST
26colon cancer29.8VIP, CCKBR, GAST, GRP, IAPP, SSTR2
27duodenal gastrinoma10.7
28hepatitis10.6
29gastric gastrinoma10.5
30hepatitis a10.3
31duodenal obstruction10.0
32von hippel-lindau disease10.0MEN1
33duodenal neoplasm10.0SST
34esophageal atresia10.0SHH
35cholelithiasis10.0SST
36hirschsprung's disease10.0VIP
37carney complex10.0MEN1
38parkinson's disease10.0SHH
39gigantism10.0SST
40constipation10.0VIP
41hyperinsulinemic hypoglycemia10.0SST, GAST
42parathyroid adenoma10.0CHGA, MEN1
43apudoma10.0SST
44dyspepsia10.0GAST
45neuroblastoma10.0SYP, VIP
46glioblastoma multiforme10.0GRP, CCKBR
47pancreas disease10.0SCTR, SCT, GAST
48ganglioneuroblastoma10.0VIP, SYP
49merkel cell carcinoma10.0CHGA, SYP
50dementia10.0GRP, SYP

Graphical network of the top 20 diseases related to Gastrinoma:



Diseases related to gastrinoma

Clinical Features for Gastrinoma

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Drugs & Therapeutics for Gastrinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Gastrinoma

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Anatomical Context for Gastrinoma

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32MalaCards
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MalaCards organs/tissues related to Gastrinoma:

32
Pancreas, Small intestine, Liver, Lymph node, Testes, Bone, Pancreatic islet, Spleen, Colon

Animal Models for Gastrinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Gastrinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.4CCKBR, PDX1, GAST, MEN1, SHH, SSTR2
2MP:00053879.4CCKBR, PDX1, SCTR, GAST, MEN1, SHH
3MP:00053799.3VIP, CCKBR, PDX1, GAST, MEN1, SHH
4MP:00053769.0GLP1R, VIP, CCKBR, PDX1, SCTR, SCT

Publications for Gastrinoma

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50PubMed
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Articles related to Gastrinoma:

(show top 50)    (show all 390)
idTitleAuthorsYear
1
Biliary tree gastrinomas in multiple endocrine neoplasia type 1 syndrome. (24363522)
2013
2
Primary hepatic gastrinoma as an unusual manifestation of zollinger-ellison syndrome. (23271988)
2012
3
Impact of lymphadenectomy on survival in surgery for sporadic gastrinoma (Br J Surg 2012; 99: 1234-1240). (22864883)
2012
4
Primary gastrinoma of lymph node: fact or fiction? (19350854)
2009
5
Imaging of gastrinomas by nuclear medicine methods. (17985094)
2007
6
Recurrent gastrinoma in the mesentery 19 years after primary resection. (17420931)
2007
7
The value of endoscopic ultrasound in localizing gastrinoma. (17985092)
2007
8
Secretin-receptor and secretin-receptor-variant expression in gastrinomas: correlation with clinical and tumoral features and secretin and calcium provocative test results. (17711922)
2007
9
Gastrinoma (duodenal and pancreatic). (17312377)
2006
10
Patients with multiple endocrine neoplasia type 1 with gastrinomas have an increased risk of severe esophageal disease including stricture and the premalignant condition, Barrett's esophagus. (16249283)
2006
11
Changing treatment strategy for gastrinoma in patients with Zollinger-Ellison syndrome. (16369713)
2006
12
Gastrinomas associated with MEN-1 syndrome: new insights for the diagnosis and management in a series of 11 patients. (16334754)
2005
13
Cushing's syndrome from ectopic production of corticotropin by a metastatic gastrinoma. (12917066)
2003
14
Twenty-two years' survival of metastatic gastrinoma evidenced recently by somatostatin-receptor-specific scintigraphy. (11953703)
2002
15
Gastrinoma. (12095598)
2002
16
Case presentation of gastrinoma combined with gastric carcinoid with the longest survival record -- Zollinger-Ellison syndrome: pathophysiology, diagnosis and therapy. (12070442)
2002
17
Metastatic gastrinoma to the liver 20 years after primary resection. (11023045)
2000
18
Somatostatin scan positive gastrinoma ocular metastasis. (10636690)
1999
19
Surgical resection of intracardiac gastrinoma. (10197684)
1999
20
Gastrinoma: advances in localization and treatment. (9735137)
1998
21
Primary cardiac gastrinoma causing Zollinger-Ellison syndrome. (9024311)
1997
22
Omeprazole in a dog with gastrinoma. (9470166)
1997
23
Mechanisms of bombesin on growth of gastrinoma (PT) in vivo. (8943970)
1996
24
Surgery in Zollinger-Ellison syndrome alters the natural history of gastrinoma. (7916560)
1994
25
Marked gastric mucosal hyperplasia without definite peptic ulceration related to a multifocal hepatic gastrinoma. (7815264)
1994
26
An evaluation of human recombinant alpha interferon in patients with metastatic gastrinoma. (8405864)
1993
27
Chromogranin A and pancreastatin-like immunoreactivity in serum of gastrinoma patients. (8323758)
1993
28
Hepatic gastrinoma. (8348490)
1993
29
Curative resection of multiple gastrinomas aided by selective arterial secretin injection test and intraoperative secretin test. (2397650)
1990
30
Beta-adrenergic regulation of gastrin release from gastrinoma cells. (2155479)
1990
31
Zollinger-Ellison syndrome. Recent advances in the management of the gastrinoma. (2184129)
1990
32
Multiple endocrine neoplasia type II with Zollinger-Ellison syndrome caused by a solitary pancreatic gastrinoma. (2567786)
1989
33
Zollinger-Ellison syndrome (gastrinoma). Current diagnosis and treatment. (2882614)
1987
34
Identification of gastrin molecular variants in gastrinoma syndrome. (3554401)
1987
35
Effect of somatostatin analogue (SMS 201-995) on molecular species of gastrin in gastrinoma. (2891204)
1987
36
Removal of mesenteric gastrinoma: a case report. (3945926)
1986
37
Evaluation of NH2-terminus gastrins in gastrinoma syndrome. (2870076)
1986
38
Zollinger-Ellison syndrome associated with a renal gastrinoma in a child. (2878987)
1986
39
Expression of human gastrin gene in normal and gastrinoma tissues. (3034736)
1986
40
Effect of secretin on gastrin release from gastrinoma cells in vitro. (3787478)
1986
41
Gastrinoma: factors influencing prognosis. (2857058)
1985
42
Effects of secretin on parathyroid hormone and calcium in normal subjects, patients with hyperparathyroidism and patients with gastrinoma. (3993434)
1985
43
Extrapancreatic, extraintestinal gastrinoma: effective treatment by surgery. (6281644)
1982
44
Intra-arterial use of streptozotocin in a case of metastatic malignant gastrinoma. (6459842)
1981
45
Long-term cimetidine and anticholinergic therapy in patients with gastrinoma. (474882)
1979
46
Gastrinoma associated with common bile duct obstruction and the ectopic production of ACTH. (222162)
1979
47
Zollinger-Ellison syndrome treated by endoscopic removal of a duodenal gastrinoma. (732916)
1978
48
Benign duodenal gastrinoma associated with the Zollinger-Ellison syndrome. (610461)
1977
49
Diagnosis of gastrinoma by the secretin suppression test. (982259)
1976
50
Antor-pyloric gastrinoma associated with pancreatic nesidioblastosis and proliferation of islets. (4201098)
1973

Genetic Variations for Gastrinoma

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Expression for genes affiliated with Gastrinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gastrinoma

Search GEO for disease gene expression data for Gastrinoma.

Pathways for genes affiliated with Gastrinoma

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29KEGG, 53Reactome, 12EMD Millipore, 37NCBI BioSystems Database
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Compounds for genes affiliated with Gastrinoma

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44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 24HMDB, 28IUPHAR
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Compounds related to Gastrinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 182)
idCompoundScoreTop Affiliating Genes
1forskolin44 49 1112.5SCT, SSTR2, PDX1
2pasireotide44 1111.4SSTR1, SST, SSTR2, SSTR5
3(1r,1s,3r/1r,1r,3s)-l-054,2645910.4SSTR5, SST, SSTR1, SSTR2
4cyclosomatostatin5910.4SSTR5, SSTR2, SSTR1, SST
5cyn 1548065910.4SSTR1, SST, SSTR5, SSTR2
6somatostatin59 2411.4SSTR5, SSTR2, SSTR1, SST
7tyr-3-octreotide4410.4VIP, SSTR2, SST
8atropine44 28 1112.3SCT, GRP, GAST
9pepsinogen4410.3GAST, CHGA, GRP, SCT
10som-2302810.3SSTR1, SSTR2, SSTR5
11lanreotide44 2811.3SSTR5, SSTR2, SSTR1, SST, CHGA
12loxiglumide4410.3SST, GRP, GAST, SCT, CCKBR
13omeprazole44 28 49 11 2414.3SCT, GAST, CHGA, CCKBR, SST
14minigastrin4410.3SST, GRP, GAST, CCKBR, VIP
15bim 234542810.2SSTR5, SSTR1, SSTR2
16111in-pentetreotide4410.2SSTR1, SSTR2, SSTR5, CHGA, SYP, SST
175-hydroxyindoleacetic acid44 2411.2SST, VIP, GAST, CHGA
18streptozotocin4410.2SYP, SST, IAPP, CHGA, PDX1
19[l-tyr8]cyn 1548062810.2SSTR2, SSTR5, SSTR1
20dtpa4410.2GAST, CCKBR, SST, SSTR2, GRP, NMB
21propranolol44 28 49 11 2414.1VIP, GRP, CHGA, GAST, SCT, SST
22cgp 239962810.1SSTR2, SSTR5, SSTR1
23bim 236272810.1SSTR1, SSTR2, SSTR5
24c-peptide4410.1GLP1R, CHGA, PDX1, SCT, GAST, IAPP
25oxyntomodulin44 5911.0GRP, CHGA, GAST, SCT, VIP, GLP1R
26carbachol44 28 1112.0GRP, SST, GAST, VIP, CHGA, SCT
27guanine44 11 2412.0CHGA, VIP, SSTR2, GRP, CCKBR, SCT
28ke 1082810.0SSTR1, SSTR2, SSTR5
295-hydroxytryptamine4410.0SYP, CHGA, SST, GRP, GAST, VIP
30isoproterenol44 1111.0SST, GRP, CHGA, GAST, SCT, VIP
31glucose449.9PYGM, GLP1R, SSTR2, GAST, SCT, PDX1
32gaba449.9SYP, SCT, GAST, CHGA, GRP, SST
33epinephrine44 11 2411.9CHGA, GAST, GRP, VIP, SCT, SST
34gnrh449.9GAST, CHGA, GRP, SST, SSTR2, VIP
35norepinephrine44 11 2411.8GRP, IAPP, SST, CHGA, SYP, GAST
36l-362,855289.8SSTR1, SSTR2, SSTR5
37acth449.7GRP, CHGA, SYP, GAST, SCT, CCKBR
38octreotide44 59 28 1112.7SST, SSTR2, GRP, SSTR5, VIP, CCKBR
39thymidine44 2410.7SSTR5, VIP, CCKBR, PDX1, SCT, GAST
40histamine44 28 2411.7VIP, CCKBR, SCT, GAST, CHGA, SSTR2
41dopamine44 28 11 2412.7VIP, CCKBR, SCT, GAST, CHGA, GRP
42arginine449.7VIP, SCT, SST, IAPP, GRP, PYGM
43vegf449.7GAST, GRP, SST, SYP, CHGA, MEN1
44cyclic amp44 2410.6SCT, GLP1R, SSTR1, IAPP, GRP, CHGA
45testosterone44 59 11 2412.6SST, IAPP, CHGA, GRP, SYP, GAST
46acetylcholine44 49 28 11 2413.5CHGA, VIP, CCKBR, NMB, SCTR, SST
47adenylate449.4GRP, VIP, SST, SSTR1, CHGA, SSTR2
48serine449.4GRP, CHGA, SYP, VIP, PDX1, CCKBR
49tyrosine449.3MEN1, SCT, GAST, SYP, CHGA, SSTR2
50calcium44 49 11 2411.9SSTR1, NMB, GLP1R, SSTR2, SSTR5, IAPP

GO Terms for genes affiliated with Gastrinoma

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16Gene Ontology
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Cellular components related to Gastrinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.5NMB, SST, IAPP, GRP, CHGA, GAST

Biological processes related to Gastrinoma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00718710.3SSTR5, SSTR2, SSTR1
2cellular response to estradiol stimulusGO:07139210.2SSTR1, SSTR2
3forebrain developmentGO:03090010.2SSTR1, SSTR2, SHH
4response to nutrientGO:00758410.1SSTR2, SSTR1, SST
5digestionGO:00758610.1SST, SSTR1, SSTR2, SCTR, CCKBR
6glucose homeostasisGO:04259310.1NMB, SSTR5, PDX1
7positive regulation of cell proliferationGO:00828410.0VIP, CCKBR, PDX1, SHH, NMB
8negative regulation of cell proliferationGO:00828510.0PDX1, MEN1, SSTR5, SSTR2, SSTR1, SST
9G-protein coupled receptor signaling pathwayGO:00718610.0SST, SSTR5, GAST, SCTR, VIP
10cell-cell signalingGO:00726710.0SHH, IAPP, SSTR2, SSTR1, SST, NMB
11elevation of cytosolic calcium ion concentrationGO:0072049.8NMB, GLP1R, CCKBR

Molecular functions related to Gastrinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1somatostatin receptor activityGO:00499410.1SSTR1, SSTR2, SSTR5
2hormone activityGO:0051799.5NMB, SST, IAPP, GAST, SCT, VIP

Products for genes affiliated with Gastrinoma

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Sources for Gastrinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet