MCID: GST030
MIFTS: 40

Gastrinoma malady

Gastrointestinal diseases, Cancer diseases categories

Aliases & Classifications for Gastrinoma

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 61UMLS, 39NCIt, 56SNOMED-CT, 33MeSH
See all sources

Aliases & Descriptions for Gastrinoma:

Name: Gastrinoma 8 10 44 61
Gastrin Secreting Tumor 8
Gastrinoma, Malignant 61
 
Malignant Gastrinoma 8
Gastrin Cell Tumour 8


Classifications:



External Ids:

Disease Ontology8 DOID:5577
NCIt39 C3050
MeSH33 D015408

Summaries for Gastrinoma

About this section
Wikipedia:64 A gastrinoma is a tumor in the pancreas or duodenum that secretes excess of gastrin leading to... more...

MalaCards based summary: Gastrinoma, also known as gastrin secreting tumor, is related to zollinger-ellison syndrome and neuroendocrine tumor. An important gene associated with Gastrinoma is SCT (secretin), and among its related pathways are G alpha (s) signalling events and Neuropeptides signaling through G protein alpha i and G protein alpha q. The compounds loxiglumide and omeprazole have been mentioned in the context of this disorder. Affiliated tissues include pancreas, small intestine and lymph node, and related mouse phenotype homeostasis/metabolism.

Disease Ontology:8 A neuroendocrine tumor that results in an overproduction of gastric acid.

Related Diseases for Gastrinoma

About this section

Diseases related to Gastrinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1zollinger-ellison syndrome31.7MEN1, SCT
2neuroendocrine tumor30.7SCT, MEN1, CCKBR
3gastritis30.6CCKBR, SCT
4atrophic gastritis30.6SCT, MEN1
5glucagonoma30.3SCT, SSTR5, MEN1
6hyperparathyroidism30.3MEN1, SCT
7insulinoma30.3SCT, IAPP, SSTR5, MEN1
8islet cell tumor30.3MEN1, IAPP
9prolactinoma30.2MEN1, SSTR5
10multiple endocrine neoplasia 130.1PYGM, MEN1
11adenocarcinoma29.9CCKBR, MEN1, IAPP, SCT
12duodenitis10.7
13multiple endocrine neoplasia10.7
14duodenal gastrinoma10.7
15pancreatitis10.6
16hepatitis10.6
17pancreatic gastrinoma10.5
18gastric gastrinoma10.3
19vipoma10.3MEN1, SCT
20primary hyperparathyroidism10.3MEN1, SCT
21cushing's syndrome10.3
22gastrointestinal system disease10.2SCT, CCKBR
23cholangiocarcinoma10.2SCT, CCKBR
24acute pancreatitis10.2IAPP, SCT
25diarrhea10.2
26alcohol dependence10.2CCKBR, SCT
27acromegaly10.1SSTR5, MEN1
28hypoglycemia10.1SCT, IAPP
29duodenal ulcer10.1
30esophagitis10.1
31pituitary tumors10.1MEN1, SSTR5
32pancreatic cancer10.1CCKBR, SCT
33hyperinsulinism10.1IAPP, SCT
34hypercalcemia10.1MEN1, IAPP, SCT
35pituitary adenoma10.0SSTR5, MEN1
36lung benign neoplasm10.0MEN1, NMB
37meningioma, familial10.0SSTR5, MEN1, CCKBR
38adenoma10.0MEN1, SSTR5, SCT
39hepatocellular carcinoma10.0CCKBR, MEN1, SCT
40gastrointestinal stromal tumor10.0
41insulin-like growth factor i10.0
42neurofibromatosis, type 210.0
43hemangioma10.0
44somatostatinoma10.0
45neurofibromatosis10.0
46mixed ductal-endocrine carcinoma10.0
47gastroduodenitis10.0
48phaeochromocytoma10.0
49pernicious anemia10.0
50esophageal disease10.0

Graphical network of the top 20 diseases related to Gastrinoma:



Diseases related to gastrinoma

Symptoms for Gastrinoma

About this section

Drugs & Therapeutics for Gastrinoma

About this section

FDA approved drugs:

id Drug Name Active Ingredient(s)13 Pharmaceutical Company Approval Date
1
SecreFlo13 SECRETIN SECRETIN SYNTHETIC PORCINE Repligen Approved April 2002
FDA Label: SecreFlo
Malady that Drug Treats: Pancreatic dysfunction and gastrinoma
Indications and Usage:13 SecreFlo is indicated for use in secretin stimulation testing for:; (1) Stimulation of pancreatic secretions, including bicarbonate, to aid in the diagnosis of; pancreatic exocrine dysfunction,; (2) Stimulation of gastrin secretion to aid in the diagnosis of gastrinoma.
DrugBank Targets:11 1. Secretin receptor
Mechanism of Action:13 
Target: secreted pancreatic juices
Action: increase volume and bicarbonate content
FDA: The primary action of SecreFlo is to increase the volume and bicarbonate content of; secreted pancreatic juices. The standard unit of activity used for SecreFlo is the clinical; unit defined by Jorpes & Mutt in 1966. (1) In the validated cat bioassay, which was used; to define and quantitate the biological activity of secretin and as the release test for the; biologically derived porcine secretin product, SecreFlo demonstrates a potency of; approximately 5000 clinical units (CU) per milligram of peptide as opposed to 3000 CU; per mg for biologically derived porcine secretin. As a pure peptide drug product,; SecreFlo"! dosing is expressed by weight in micrograms. The relationship of; micrograms of secretin to biological activity is 0.2 mcg = 1 CU.

Drug clinical trials:

Search ClinicalTrials for Gastrinoma

Search NIH Clinical Center for Gastrinoma

Genetic Tests for Gastrinoma

About this section

Anatomical Context for Gastrinoma

About this section

MalaCards organs/tissues related to Gastrinoma:

31
Pancreas, Small intestine, Lymph node, Liver, Testes, Bone, Pancreatic islet, Spleen, Colon

Animal Models for Gastrinoma or affiliated genes

About this section

MGI Mouse Phenotypes related to Gastrinoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.1CCKBR, MEN1, SSTR5, IAPP, SCT

Publications for Gastrinoma

About this section

Articles related to Gastrinoma:

(show top 50)    (show all 397)
idTitleAuthorsYear
1
An evaluation of chromogranin A versus gastrin and progastrin in gastrinoma diagnosis and control. (24796622)
2014
2
Primary lymph node gastrinoma. A diagnosis of exclusion. A case for duodenotomy in the setting of a negative imaging for primary tumor: A case report and review of the literature. (25462049)
2014
3
Partial pancreaticoduodenectomy can provide cure for duodenal gastrinoma associated with multiple endocrine neoplasia type 1. (22580937)
2013
4
Duodenal gastrinoma with multiple gastric neuroendocrine tumors secondary to chronic Helicobacter pylori gastritis. (22588069)
2012
5
Biochemically curative surgery for gastrinoma in multiple endocrine neoplasia type 1 patients. (21455335)
2011
6
Somatostatin Receptor Scintigraphy Findings in a Patient with Metastatic Gastrinoma and MEN 1 Syndrome. (23487241)
2011
7
A case of recurrent gastrinoma in the liver with a review of "primary" hepatic gastrinomas. (21686999)
2009
8
Insulinoma and gastrinoma syndromes from a single intrapancreatic neuroendocrine tumor. (18252785)
2008
9
Hyperplastic polyposis and cancer of the colon with gastrinoma of the duodenum. (16683006)
2006
10
Assessment of the risk of iatrogenic hypergastrinaemia from patients with gastrinoma. (16433885)
2006
11
50-year appraisal of gastrinoma: recommendations for staging and treatment. (16735203)
2006
12
Gastrin-17 specific antibodies are too specific for gastrinoma diagnosis but stain G-cells. (16036513)
2005
13
The diagnosis and treatment of insulinoma and gastrinoma]. (15045936)
2004
14
Primary lymph node gastrinoma: a case report. (12760612)
2003
15
Her-2/neu expression and gene amplification in gastrinomas: correlations with tumor biology, growth, and aggressiveness. (12097278)
2002
16
Gastric collision between a papillotubular adenocarcinoma and a gastrinoma in a patient with Zollinger-Ellison syndrome. (12447676)
2002
17
Somatostatin scan positive gastrinoma ocular metastasis. (10636690)
1999
18
Surgical resection of intracardiac gastrinoma. (10197684)
1999
19
The origin of sporadic gastrinomas within the gastrinoma triangle: a theory. (9438752)
1998
20
Octreotide scintigraphy: a prerequisite for liver transplantation for metastatic gastrinoma. (9623469)
1998
21
Distinguishing small hepatic hemangiomas from vascular liver metastases in gastrinoma: use of a somatostatin-receptor scintigraphic agent. (8988205)
1997
22
Gastrinoma: a retrospective study of four cases (1985-1995). (9358421)
1997
23
Gastrinoma before Zollinger and Ellison. (9324128)
1997
24
Is gastrinoma a medical disease? (9165698)
1996
25
Prospective study of surgical resection of duodenal and pancreatic gastrinomas in multiple endocrine neoplasia type 1. (7491542)
1995
26
Somatostatin receptor scintigraphy in neuroendocrine tumors exemplified by a patient with hepatic metastases of gastrinoma]. (7513113)
1994
27
Gastrinomas demonstrate amplification of the HER-2/neu proto-oncogene. (7911296)
1994
28
Surgery in Zollinger-Ellison syndrome alters the natural history of gastrinoma. (7916560)
1994
29
Duodenal gastrinoma: the solution to the pancreatic paradox. (7806825)
1994
30
Detection of occult gastrinomas with iodine 125-labeled lanreotide and intraoperative gamma detection. (7985099)
1994
31
An evaluation of human recombinant alpha interferon in patients with metastatic gastrinoma. (8405864)
1993
32
Biologic and immunologic gastrin activity in serum of patients with gastrinoma. Bioassay of gastrin activity in serum. (1475620)
1992
33
Effects of curative gastrinoma resection on gastric secretory function and antisecretory drug requirement in the Zollinger-Ellison syndrome. (1537514)
1992
34
Intraocular transplants of a human gastrinoma in immuno-suppressed rats: morphological, chromatographic and functional studies. (2740530)
1989
35
Gastrinoma. New medical and surgical approaches. (2567061)
1989
36
Gastrinoma (Zollinger-Ellison Syndrome) in the Dog and cat. (17423047)
1988
37
Distribution, molecular forms, and bioactivity of immunoreactive gastrin in a patient with metastatic gastrinoma. (3631036)
1987
38
Prospective study of the ability of computed axial tomography to localize gastrinomas in patients with Zollinger-Ellison syndrome. (3556996)
1987
39
Ectopic gastrinoma and Zollinger-Ellison syndrome. (3710471)
1986
40
Aggressive resection of metastatic disease in selected patients with malignant gastrinoma. (2938550)
1986
41
Case 3. Renal gastrinoma with Zollinger-Ellison syndrome. (3588443)
1986
42
Synergistic interaction between an H2-receptor antagonist and enprostil on 24-hour intragastric pH, serum gastrin concentration, and tissue immunoperoxidase staining for gastrin, somatostatin, and serotonin in a patient with metastatic gastrinoma. (2878726)
1986
43
Gastrinoma: factors influencing prognosis. (2857058)
1985
44
Endoscopic diagnosis and removal of a duodenal wall gastrinoma. (6475895)
1984
45
Thirty years' experience with gastrinoma. (6148806)
1984
46
Diagnosis and management of gastrinoma (Zollinger-Ellison Syndrome) (7070121)
1982
47
Laboratory diagnosis of gastrinoma. I. A prospective evaluation of gastric analysis and fasting serum gastrin levels. (7070117)
1982
48
Diagnosis of gastrinoma by the secretin suppression test. (982259)
1976
49
Proceedings: Malignant gastrinoma following total gastrectomy. (4273862)
1974
50
Antor-pyloric gastrinoma associated with pancreatic nesidioblastosis and proliferation of islets. (4201098)
1973

Variations for Gastrinoma

About this section

Cosmic variations for Gastrinoma:

6
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
122579MEN1small intestine,duodenum,carcinoid-endocrine tumour,gastrinoma1

Expression for genes affiliated with Gastrinoma

About this section
Search GEO for disease gene expression data for Gastrinoma.

Pathways for genes affiliated with Gastrinoma

About this section

Compounds for genes affiliated with Gastrinoma

About this section

Compounds related to Gastrinoma according to GeneCards Suite gene sharing:

(show all 24)
idCompoundScoreTop Affiliating Genes
1loxiglumide4410.0CCKBR, SCT
2omeprazole44 50 28 24 1113.9CCKBR, SCT
3tetrodotoxin44 60 2811.8SCT, CCKBR
4c-peptide449.8SCT, IAPP
5dtpa449.8NMB, CCKBR
6amphetamine44 50 1111.7IAPP, CCKBR
7opiate449.6NMB, IAPP
8ibmx44 60 2811.6IAPP, SCT
9amide449.5CCKBR, IAPP
10catecholamine449.5SCT, IAPP
11histamine44 28 2411.4SCT, IAPP, CCKBR
12octreotide44 60 28 1112.4SSTR5, SCT, CCKBR
13estradiol44 24 1111.4CCKBR, IAPP, SCT
14acth449.3CCKBR, SCT, SSTR5
15adenylate449.2CCKBR, IAPP, SCT
16cocaine44 1110.2IAPP, CCKBR
17acetylcholine44 50 28 24 1113.0SCT, IAPP, NMB, CCKBR
18dopamine44 28 24 1111.8IAPP, CCKBR, SSTR5, SCT
19serine448.8SCT, IAPP, MEN1, CCKBR
20hydrogen44 249.6PYGM, SCT, NMB, CCKBR
21thymidine44 249.5MEN1, SCT, IAPP, SSTR5, CCKBR
22arginine448.1CCKBR, NMB, SCT, PYGM, IAPP
23tyrosine448.1SCT, PYGM, MEN1, SSTR5, CCKBR
24calcium44 50 24 1110.9NMB, SCT, CCKBR, MEN1, SSTR5, IAPP

GO Terms for genes affiliated with Gastrinoma

About this section

Biological processes related to Gastrinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cytosolic calcium ion concentrationGO:00072049.5NMB, CCKBR
2glucose homeostasisGO:00425939.0NMB, SSTR5

Molecular functions related to Gastrinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051799.1NMB, IAPP, SCT

Sources for Gastrinoma

About this section
2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet