MCID: GST030
MIFTS: 40

Gastrinoma malady

Gastrointestinal diseases, Cancer diseases categories

Aliases & Classifications for Gastrinoma

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 38NCIt, 55SNOMED-CT, 33MeSH
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Gastrinoma, Aliases & Descriptions:

Name: Gastrinoma 9 11 43 60
Gastrin Secreting Tumor 9
Gastrinoma, Malignant 60
 
Malignant Gastrinoma 9
Gastrin Cell Tumour 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology9 DOID:5577
NCIt38 C3050
MeSH33 D015408

Summaries for Gastrinoma

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Wikipedia:63 A gastrinoma is a tumor in the pancreas or duodenum that secretes excess of gastrin leading to... more...

MalaCards based summary: Gastrinoma, also known as gastrin secreting tumor, is related to zollinger-ellison syndrome and neuroendocrine tumor. An important gene associated with Gastrinoma is SCT (secretin), and among its related pathways are G alpha (s) signalling events and Neuropeptides signaling through G protein alpha i and G protein alpha q. The compounds loxiglumide and omeprazole have been mentioned in the context of this disorder. Affiliated tissues include pancreas, small intestine and lymph node, and related mouse phenotype homeostasis/metabolism.

Disease Ontology:9 A neuroendocrine tumor that results in an overproduction of gastric acid.

Related Diseases for Gastrinoma

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Diseases related to Gastrinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1zollinger-ellison syndrome31.7MEN1, SCT
2neuroendocrine tumor30.7SCT, MEN1, CCKBR
3gastritis30.6CCKBR, SCT
4atrophic gastritis30.6SCT, MEN1
5glucagonoma30.3SCT, SSTR5, MEN1
6hyperparathyroidism30.3MEN1, SCT
7insulinoma30.3SCT, IAPP, SSTR5, MEN1
8islet cell tumor30.3MEN1, IAPP
9prolactinoma30.2MEN1, SSTR5
10multiple endocrine neoplasia 130.1PYGM, MEN1
11adenocarcinoma29.9CCKBR, MEN1, IAPP, SCT
12duodenitis10.7
13multiple endocrine neoplasia10.7
14duodenal gastrinoma10.7
15pancreatitis10.6
16hepatitis10.6
17pancreatic gastrinoma10.5
18gastric gastrinoma10.3
19vipoma10.3MEN1, SCT
20primary hyperparathyroidism10.3MEN1, SCT
21cushing's syndrome10.3
22gastrointestinal system disease10.2SCT, CCKBR
23cholangiocarcinoma10.2SCT, CCKBR
24acute pancreatitis10.2IAPP, SCT
25diarrhea10.2
26alcohol dependence10.2CCKBR, SCT
27acromegaly10.1SSTR5, MEN1
28hypoglycemia10.1SCT, IAPP
29duodenal ulcer10.1
30esophagitis10.1
31pituitary tumors10.1MEN1, SSTR5
32pancreatic cancer10.1CCKBR, SCT
33hyperinsulinism10.1IAPP, SCT
34hypercalcemia10.1MEN1, IAPP, SCT
35pituitary adenoma10.0SSTR5, MEN1
36lung benign neoplasm10.0MEN1, NMB
37meningioma, familial10.0SSTR5, MEN1, CCKBR
38adenoma10.0MEN1, SSTR5, SCT
39hepatocellular carcinoma10.0CCKBR, MEN1, SCT
40gastrointestinal stromal tumor10.0
41insulin-like growth factor i10.0
42neurofibromatosis, type 210.0
43hemangioma10.0
44somatostatinoma10.0
45neurofibromatosis10.0
46mixed ductal-endocrine carcinoma10.0
47gastroduodenitis10.0
48phaeochromocytoma10.0
49pernicious anemia10.0
50esophageal disease10.0

Graphical network of the top 20 diseases related to Gastrinoma:



Diseases related to gastrinoma

Symptoms for Gastrinoma

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Drugs & Therapeutics for Gastrinoma

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Drug clinical trials:

Search ClinicalTrials for Gastrinoma

Search NIH Clinical Center for Gastrinoma

Genetic Tests for Gastrinoma

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Anatomical Context for Gastrinoma

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MalaCards organs/tissues related to Gastrinoma:

31
Pancreas, Small intestine, Lymph node, Liver, Testes, Bone, Pancreatic islet, Spleen, Colon

Animal Models for Gastrinoma or affiliated genes

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MGI Mouse Phenotypes related to Gastrinoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.1CCKBR, MEN1, SSTR5, IAPP, SCT

Publications for Gastrinoma

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Articles related to Gastrinoma:

(show top 50)    (show all 397)
idTitleAuthorsYear
1
An evaluation of chromogranin A versus gastrin and progastrin in gastrinoma diagnosis and control. (24796622)
2014
2
Primary lymph node gastrinoma. A diagnosis of exclusion. A case for duodenotomy in the setting of a negative imaging for primary tumor: A case report and review of the literature. (25462049)
2014
3
Partial pancreaticoduodenectomy can provide cure for duodenal gastrinoma associated with multiple endocrine neoplasia type 1. (22580937)
2013
4
Duodenal gastrinoma with multiple gastric neuroendocrine tumors secondary to chronic Helicobacter pylori gastritis. (22588069)
2012
5
Biochemically curative surgery for gastrinoma in multiple endocrine neoplasia type 1 patients. (21455335)
2011
6
Somatostatin Receptor Scintigraphy Findings in a Patient with Metastatic Gastrinoma and MEN 1 Syndrome. (23487241)
2011
7
A case of recurrent gastrinoma in the liver with a review of "primary" hepatic gastrinomas. (21686999)
2009
8
Insulinoma and gastrinoma syndromes from a single intrapancreatic neuroendocrine tumor. (18252785)
2008
9
Hyperplastic polyposis and cancer of the colon with gastrinoma of the duodenum. (16683006)
2006
10
Assessment of the risk of iatrogenic hypergastrinaemia from patients with gastrinoma. (16433885)
2006
11
50-year appraisal of gastrinoma: recommendations for staging and treatment. (16735203)
2006
12
Gastrin-17 specific antibodies are too specific for gastrinoma diagnosis but stain G-cells. (16036513)
2005
13
The diagnosis and treatment of insulinoma and gastrinoma]. (15045936)
2004
14
Primary lymph node gastrinoma: a case report. (12760612)
2003
15
Her-2/neu expression and gene amplification in gastrinomas: correlations with tumor biology, growth, and aggressiveness. (12097278)
2002
16
Gastric collision between a papillotubular adenocarcinoma and a gastrinoma in a patient with Zollinger-Ellison syndrome. (12447676)
2002
17
Somatostatin scan positive gastrinoma ocular metastasis. (10636690)
1999
18
Surgical resection of intracardiac gastrinoma. (10197684)
1999
19
The origin of sporadic gastrinomas within the gastrinoma triangle: a theory. (9438752)
1998
20
Octreotide scintigraphy: a prerequisite for liver transplantation for metastatic gastrinoma. (9623469)
1998
21
Distinguishing small hepatic hemangiomas from vascular liver metastases in gastrinoma: use of a somatostatin-receptor scintigraphic agent. (8988205)
1997
22
Gastrinoma: a retrospective study of four cases (1985-1995). (9358421)
1997
23
Gastrinoma before Zollinger and Ellison. (9324128)
1997
24
Is gastrinoma a medical disease? (9165698)
1996
25
Prospective study of surgical resection of duodenal and pancreatic gastrinomas in multiple endocrine neoplasia type 1. (7491542)
1995
26
Somatostatin receptor scintigraphy in neuroendocrine tumors exemplified by a patient with hepatic metastases of gastrinoma]. (7513113)
1994
27
Gastrinomas demonstrate amplification of the HER-2/neu proto-oncogene. (7911296)
1994
28
Surgery in Zollinger-Ellison syndrome alters the natural history of gastrinoma. (7916560)
1994
29
Duodenal gastrinoma: the solution to the pancreatic paradox. (7806825)
1994
30
Detection of occult gastrinomas with iodine 125-labeled lanreotide and intraoperative gamma detection. (7985099)
1994
31
An evaluation of human recombinant alpha interferon in patients with metastatic gastrinoma. (8405864)
1993
32
Biologic and immunologic gastrin activity in serum of patients with gastrinoma. Bioassay of gastrin activity in serum. (1475620)
1992
33
Effects of curative gastrinoma resection on gastric secretory function and antisecretory drug requirement in the Zollinger-Ellison syndrome. (1537514)
1992
34
Intraocular transplants of a human gastrinoma in immuno-suppressed rats: morphological, chromatographic and functional studies. (2740530)
1989
35
Gastrinoma. New medical and surgical approaches. (2567061)
1989
36
Gastrinoma (Zollinger-Ellison Syndrome) in the Dog and cat. (17423047)
1988
37
Distribution, molecular forms, and bioactivity of immunoreactive gastrin in a patient with metastatic gastrinoma. (3631036)
1987
38
Prospective study of the ability of computed axial tomography to localize gastrinomas in patients with Zollinger-Ellison syndrome. (3556996)
1987
39
Ectopic gastrinoma and Zollinger-Ellison syndrome. (3710471)
1986
40
Aggressive resection of metastatic disease in selected patients with malignant gastrinoma. (2938550)
1986
41
Case 3. Renal gastrinoma with Zollinger-Ellison syndrome. (3588443)
1986
42
Synergistic interaction between an H2-receptor antagonist and enprostil on 24-hour intragastric pH, serum gastrin concentration, and tissue immunoperoxidase staining for gastrin, somatostatin, and serotonin in a patient with metastatic gastrinoma. (2878726)
1986
43
Gastrinoma: factors influencing prognosis. (2857058)
1985
44
Endoscopic diagnosis and removal of a duodenal wall gastrinoma. (6475895)
1984
45
Thirty years' experience with gastrinoma. (6148806)
1984
46
Diagnosis and management of gastrinoma (Zollinger-Ellison Syndrome) (7070121)
1982
47
Laboratory diagnosis of gastrinoma. I. A prospective evaluation of gastric analysis and fasting serum gastrin levels. (7070117)
1982
48
Diagnosis of gastrinoma by the secretin suppression test. (982259)
1976
49
Proceedings: Malignant gastrinoma following total gastrectomy. (4273862)
1974
50
Antor-pyloric gastrinoma associated with pancreatic nesidioblastosis and proliferation of islets. (4201098)
1973

Variations for Gastrinoma

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Cosmic variations for Gastrinoma:

7
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
122579MEN1small intestine,duodenum,carcinoid-endocrine tumour,gastrinoma1

Expression for genes affiliated with Gastrinoma

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Search GEO for disease gene expression data for Gastrinoma.

Pathways for genes affiliated with Gastrinoma

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Compounds for genes affiliated with Gastrinoma

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Compounds related to Gastrinoma according to GeneCards Suite gene sharing:

(show all 24)
idCompoundScoreTop Affiliating Genes
1loxiglumide4310.0CCKBR, SCT
2omeprazole43 49 28 24 1213.9SCT, CCKBR
3tetrodotoxin43 59 2811.8SCT, CCKBR
4c-peptide439.8IAPP, SCT
5dtpa439.8CCKBR, NMB
6amphetamine43 49 1211.7CCKBR, IAPP
7opiate439.6NMB, IAPP
8ibmx43 59 2811.6IAPP, SCT
9amide439.5CCKBR, IAPP
10catecholamine439.5SCT, IAPP
11histamine43 28 2411.4CCKBR, IAPP, SCT
12octreotide43 59 28 1212.4CCKBR, SSTR5, SCT
13estradiol43 24 1211.4CCKBR, IAPP, SCT
14acth439.3CCKBR, SSTR5, SCT
15adenylate439.2CCKBR, IAPP, SCT
16cocaine43 1210.2CCKBR, IAPP
17acetylcholine43 49 28 24 1213.0SCT, IAPP, CCKBR, NMB
18dopamine43 28 24 1211.8SCT, IAPP, SSTR5, CCKBR
19serine438.8SCT, IAPP, MEN1, CCKBR
20hydrogen43 249.6NMB, CCKBR, SCT, PYGM
21thymidine43 249.5CCKBR, MEN1, SSTR5, IAPP, SCT
22arginine438.1PYGM, SCT, IAPP, CCKBR, NMB
23tyrosine438.1PYGM, SCT, SSTR5, MEN1, CCKBR
24calcium43 49 24 1210.9SCT, IAPP, SSTR5, MEN1, CCKBR, NMB

GO Terms for genes affiliated with Gastrinoma

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Biological processes related to Gastrinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cytosolic calcium ion concentrationGO:00072049.5NMB, CCKBR
2glucose homeostasisGO:00425939.0NMB, SSTR5

Molecular functions related to Gastrinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051799.1NMB, IAPP, SCT

Products for genes affiliated with Gastrinoma

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  • Antibodies
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  • Proteins
  • Kits and Assays

Sources for Gastrinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet