MCID: GST030
MIFTS: 47

Gastrinoma malady

Cancer diseases, Gastrointestinal diseases categories
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Summaries for Gastrinoma

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Wikipedia:65 A gastrinoma is a tumor in the pancreas or duodenum that secretes excess of gastrin leading to... more...

MalaCards based summary: Gastrinoma, also known as gastrin secreting tumor, is related to zollinger-ellison syndrome and neuroendocrine tumor. An important gene associated with Gastrinoma is SCT (secretin), and among its related pathways are G alpha (s) signalling events and Neuropeptides signaling through G protein alpha i and G protein alpha q. The compounds loxiglumide and omeprazole have been mentioned in the context of this disorder. Affiliated tissues include pancreas, small intestine and liver, and related mouse phenotype homeostasis/metabolism.

Disease Ontology:8 A neuroendocrine tumor that results in an overproduction of gastric acid.

Aliases & Classifications for Gastrinoma

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 39NCIt, 34MeSH
See all sources

Gastrinoma, Aliases & Descriptions:

Name: Gastrinoma 8 10 44 62
Gastrin Secreting Tumor 8 62
Gastrinoma, Malignant 62
 
Malignant Gastrinoma 8
Gastrin Cell Tumour 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology8 DOID:5577
NCIt39 C3050
MeSH34 D015408

Related Diseases for Gastrinoma

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Diseases related to Gastrinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 66)
idRelated DiseaseScoreTop Affiliating Genes
1zollinger-ellison syndrome31.7SCT, MEN1
2neuroendocrine tumor30.6CCKBR, MEN1, SCT
3gastritis30.6CCKBR, SCT
4atrophic gastritis30.6MEN1, SCT
5glucagonoma30.3MEN1, SSTR5, SCT
6hyperparathyroidism30.3SCT, MEN1
7insulinoma30.3SSTR5, SCT, IAPP, MEN1
8pancreatic islet cell tumors30.3MEN1, IAPP
9prolactinoma30.2SSTR5, MEN1
10wermer syndrome30.1MEN1, PYGM
11adenocarcinoma29.9MEN1, CCKBR, SCT, IAPP
12duodenitis10.7
13multiple endocrine neoplasia10.7
14duodenal gastrinoma10.7
15pancreatitis10.6
16hepatitis10.6
17pancreatic gastrinoma10.5
18gastric gastrinoma10.3
19vipoma10.3SCT, MEN1
20primary hyperparathyroidism10.3MEN1, SCT
21cushing's syndrome10.3
22gastrointestinal system disease10.3SCT, CCKBR
23cholangiocarcinoma10.2CCKBR, SCT
24acute pancreatitis10.2IAPP, SCT
25diarrhea10.2
26acromegaly10.2SSTR5, MEN1
27hypoglycemia10.1SCT, IAPP
28duodenal ulcer10.1
29esophagitis10.1
30pancreatic cancer10.1SCT, CCKBR
31pituitary tumors10.1SSTR5, MEN1
32hyperinsulinism10.1SCT, IAPP
33hypercalcemia10.1SCT, IAPP, MEN1
34pituitary adenoma10.0SSTR5, MEN1
35lung benign neoplasm10.0NMB, MEN1
36meningioma10.0CCKBR, MEN1, SSTR5
37liver cancer10.0SCT, MEN1, CCKBR
38adenoma10.0SCT, SSTR5, MEN1
39hemangioma10.0
40islet cell tumor10.0
41somatostatinoma10.0
42mixed ductal-endocrine carcinoma10.0
43pernicious anemia10.0
44gastrointestinal stromal tumor10.0
45barrett's esophagus10.0
46neurofibromatosis10.0
47phaeochromocytoma10.0
48gastroduodenitis10.0
49esophageal disease10.0
50hyperthyroidism10.0

Graphical network of the top 20 diseases related to Gastrinoma:



Diseases related to gastrinoma

Symptoms for Gastrinoma

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Drugs & Therapeutics for Gastrinoma

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Drug clinical trials:

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Genetic Tests for Gastrinoma

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Anatomical Context for Gastrinoma

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MalaCards organs/tissues related to Gastrinoma:

32
Pancreas, Small intestine, Liver, Lymph node, Testes, Bone, Pancreatic islet, Spleen, Colon

Animal Models for Gastrinoma or affiliated genes

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MGI Mouse Phenotypes related to Gastrinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.1CCKBR, MEN1, SSTR5, IAPP, SCT

Publications for Gastrinoma

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Articles related to Gastrinoma:

(show top 50)    (show all 393)
idTitleAuthorsYear
1
An evaluation of chromogranin A versus gastrin and progastrin in gastrinoma diagnosis and control. (24796622)
2014
2
Partial pancreaticoduodenectomy can provide cure for duodenal gastrinoma associated with multiple endocrine neoplasia type 1. (22580937)
2013
3
Duodenal gastrinoma with multiple gastric neuroendocrine tumors secondary to chronic Helicobacter pylori gastritis. (22588069)
2012
4
Biochemically curative surgery for gastrinoma in multiple endocrine neoplasia type 1 patients. (21455335)
2011
5
Somatostatin Receptor Scintigraphy Findings in a Patient with Metastatic Gastrinoma and MEN 1 Syndrome. (23487241)
2011
6
A case of recurrent gastrinoma in the liver with a review of "primary" hepatic gastrinomas. (21686999)
2009
7
Insulinoma and gastrinoma syndromes from a single intrapancreatic neuroendocrine tumor. (18252785)
2008
8
Hyperplastic polyposis and cancer of the colon with gastrinoma of the duodenum. (16683006)
2006
9
Assessment of the risk of iatrogenic hypergastrinaemia from patients with gastrinoma. (16433885)
2006
10
50-year appraisal of gastrinoma: recommendations for staging and treatment. (16735203)
2006
11
Gastrin-17 specific antibodies are too specific for gastrinoma diagnosis but stain G-cells. (16036513)
2005
12
The diagnosis and treatment of insulinoma and gastrinoma]. (15045936)
2004
13
Primary lymph node gastrinoma: a case report. (12760612)
2003
14
Her-2/neu expression and gene amplification in gastrinomas: correlations with tumor biology, growth, and aggressiveness. (12097278)
2002
15
Gastric collision between a papillotubular adenocarcinoma and a gastrinoma in a patient with Zollinger-Ellison syndrome. (12447676)
2002
16
Somatostatin scan positive gastrinoma ocular metastasis. (10636690)
1999
17
Surgical resection of intracardiac gastrinoma. (10197684)
1999
18
The origin of sporadic gastrinomas within the gastrinoma triangle: a theory. (9438752)
1998
19
Octreotide scintigraphy: a prerequisite for liver transplantation for metastatic gastrinoma. (9623469)
1998
20
Distinguishing small hepatic hemangiomas from vascular liver metastases in gastrinoma: use of a somatostatin-receptor scintigraphic agent. (8988205)
1997
21
Gastrinoma: a retrospective study of four cases (1985-1995). (9358421)
1997
22
Gastrinoma before Zollinger and Ellison. (9324128)
1997
23
Is gastrinoma a medical disease? (9165698)
1996
24
Prospective study of surgical resection of duodenal and pancreatic gastrinomas in multiple endocrine neoplasia type 1. (7491542)
1995
25
Somatostatin receptor scintigraphy in neuroendocrine tumors exemplified by a patient with hepatic metastases of gastrinoma]. (7513113)
1994
26
Gastrinomas demonstrate amplification of the HER-2/neu proto-oncogene. (7911296)
1994
27
Surgery in Zollinger-Ellison syndrome alters the natural history of gastrinoma. (7916560)
1994
28
Duodenal gastrinoma: the solution to the pancreatic paradox. (7806825)
1994
29
Detection of occult gastrinomas with iodine 125-labeled lanreotide and intraoperative gamma detection. (7985099)
1994
30
An evaluation of human recombinant alpha interferon in patients with metastatic gastrinoma. (8405864)
1993
31
Duodenal gastrinomas, duodenotomy, and duodenal exploration in the surgical management of Zollinger-Ellison syndrome. (8103249)
1993
32
Biologic and immunologic gastrin activity in serum of patients with gastrinoma. Bioassay of gastrin activity in serum. (1475620)
1992
33
Effects of curative gastrinoma resection on gastric secretory function and antisecretory drug requirement in the Zollinger-Ellison syndrome. (1537514)
1992
34
Intraocular transplants of a human gastrinoma in immuno-suppressed rats: morphological, chromatographic and functional studies. (2740530)
1989
35
Gastrinoma. New medical and surgical approaches. (2567061)
1989
36
Gastrinoma (Zollinger-Ellison Syndrome) in the Dog and cat. (17423047)
1988
37
Distribution, molecular forms, and bioactivity of immunoreactive gastrin in a patient with metastatic gastrinoma. (3631036)
1987
38
Prospective study of the ability of computed axial tomography to localize gastrinomas in patients with Zollinger-Ellison syndrome. (3556996)
1987
39
Ectopic gastrinoma and Zollinger-Ellison syndrome. (3710471)
1986
40
Aggressive resection of metastatic disease in selected patients with malignant gastrinoma. (2938550)
1986
41
Case 3. Renal gastrinoma with Zollinger-Ellison syndrome. (3588443)
1986
42
Synergistic interaction between an H2-receptor antagonist and enprostil on 24-hour intragastric pH, serum gastrin concentration, and tissue immunoperoxidase staining for gastrin, somatostatin, and serotonin in a patient with metastatic gastrinoma. (2878726)
1986
43
Gastrinoma: factors influencing prognosis. (2857058)
1985
44
Endoscopic diagnosis and removal of a duodenal wall gastrinoma. (6475895)
1984
45
Thirty years' experience with gastrinoma. (6148806)
1984
46
Diagnosis and management of gastrinoma (Zollinger-Ellison Syndrome) (7070121)
1982
47
Laboratory diagnosis of gastrinoma. I. A prospective evaluation of gastric analysis and fasting serum gastrin levels. (7070117)
1982
48
Diagnosis of gastrinoma by the secretin suppression test. (982259)
1976
49
Proceedings: Malignant gastrinoma following total gastrectomy. (4273862)
1974
50
Antor-pyloric gastrinoma associated with pancreatic nesidioblastosis and proliferation of islets. (4201098)
1973

Variations for Gastrinoma

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Expression for genes affiliated with Gastrinoma

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Expression patterns in normal tissues for genes affiliated with Gastrinoma

Search GEO for disease gene expression data for Gastrinoma.

Pathways for genes affiliated with Gastrinoma

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Compounds for genes affiliated with Gastrinoma

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Compounds related to Gastrinoma according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
1loxiglumide4410.0CCKBR, SCT
2omeprazole44 50 28 24 1113.9CCKBR, SCT
3tetrodotoxin44 61 2811.8SCT, CCKBR
4c-peptide449.8SCT, IAPP
5dtpa449.8NMB, CCKBR
6amphetamine44 50 1111.7IAPP, CCKBR
7opiate449.6NMB, IAPP
8ibmx44 61 2811.6IAPP, SCT
9amide449.5CCKBR, IAPP
10catecholamine449.5SCT, IAPP
11histamine44 28 2411.4SCT, IAPP, CCKBR
12octreotide44 61 28 1112.4SSTR5, SCT, CCKBR
13estradiol44 24 1111.4CCKBR, IAPP, SCT
14acth449.3CCKBR, SCT, SSTR5
15adenylate449.2CCKBR, IAPP, SCT
16cocaine44 1110.2IAPP, CCKBR
17acetylcholine44 50 28 24 1113.0SCT, IAPP, NMB, CCKBR
18dopamine44 28 24 1111.8IAPP, CCKBR, SSTR5, SCT
19serine448.8SCT, IAPP, MEN1, CCKBR
20hydrogen44 249.6PYGM, SCT, NMB, CCKBR
21thymidine44 249.5MEN1, SCT, IAPP, SSTR5, CCKBR
22arginine448.1CCKBR, NMB, SCT, PYGM, IAPP
23tyrosine448.1SCT, PYGM, MEN1, SSTR5, CCKBR
24calcium44 50 24 1110.9NMB, SCT, CCKBR, MEN1, SSTR5, IAPP

GO Terms for genes affiliated with Gastrinoma

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Biological processes related to Gastrinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cytosolic calcium ion concentrationGO:0072049.5NMB, CCKBR
2glucose homeostasisGO:0425939.0NMB, SSTR5

Molecular functions related to Gastrinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.1NMB, IAPP, SCT

Products for genes affiliated with Gastrinoma

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Sources for Gastrinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet