MCID: GST044
MIFTS: 68

Gastritis malady

Gastrointestinal diseases category

Summaries for Gastritis

About this section
Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Gastritis is inflammation of the lining of the stomach and has many possible causes. Common causes of... more...

MalaCards: Gastritis, also known as idiopathic erosive/hemorrhagic gastritis, is related to atrophic gastritis and duodenitis. An important gene associated with Gastritis is PGC (progastricsin (pepsinogen C)), and among its related pathways are Immune response Bacterial infections in normal airways and Doxorubicin Pathway, Pharmacokinetics. The drugs sucralfate and cat's claw preparation and the compounds cysteine and histamine have been mentioned in the context of this disorder. Affiliated tissues include testes, t cells and colon, and related mouse phenotypes are homeostasis/metabolism and immune system.

Disease Ontology:8 A stomach disease that is an inflammation of the lining of the stomach.

Aliases & Classifications for Gastritis

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

gastritis 8 10 44 60
idiopathic erosive/hemorrhagic gastritis 8 60
acute gastric mucosal erosion 8 60
other specified gastritis 8 60
chronic gastritis 8 60
acute gastritis 8 60
other specified gastritis, without mention of hemorrhage 8
acute gastritis, without mention of hemorrhage 8
acute gastritis without mention of hemorrhage 8
other specified gastritis, with hemorrhage 8
acute gastritis, with hemorrhage 8
acute gastritis with hemorrhage 8
other specified gastritis nos 8
acute haemorrhagic gastritis 8
acute hemorrhagic gastritis 8
chronic gastritis nos 8
gastritis hemorrhagic 8
gastritis unspecified 8
hemorrhagic gastritis 8
erosive gastropathy 8
erosive gastritis 8
gastritis chronic 44
gastritis erosive 44


External Ids:

Disease Ontology8 DOID:4029
NCIt39 C26780
MeSH34 D005756
ICD1025 K29.0, K29.7

Related Diseases for Gastritis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Gastritis family:

Bacterial Gastritis Viral Gastritis

Diseases related to Gastritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 310)
idRelated DiseaseScoreTop Affiliating Genes
1atrophic gastritis31.7IL1RN, CDX2, CHGA, GHRL, AKR1A1, TFF2
2duodenitis31.1S100A8, GAST
3gastric ulcer31.0GHRL, TFF2, TFF1, GAST, S100A8, ODC1
4peptic ulcer30.9IL8, PGC, AKR1A1, GAST, SCT, S100A8
5duodenal ulcer30.9S100A8, SCT, GAST, IL1RN
6bile reflux30.8TFF1
7adenocarcinoma30.7NOS2, CDX2, CHGA, GHRL, AREG, TFF2
8esophagitis30.7CAT, S100A8, GAST, CDX2
9gastric adenocarcinoma30.6ODC1, S100A8, GAST, TFF1, DEFB4A, CHGA
10duodenogastric reflux30.5GAST
11stomach cancer30.5GAST, CDX2, PGC
12celiac disease30.4GHRL
13dyspepsia30.4GHRL, GAST
14deficiency anemia30.4GHRL, AREG
15pancreatitis30.3SCT, SOD1
16zollinger-ellison syndrome30.2SCT, GAST, CHGA
17inflammatory bowel disease30.2S100A8, SCT, TFF1, TFF2, AREG, DEFB4A
18hepatitis30.2AKR1A1, CAT
19gastroduodenitis30.2GAST
20adenoma30.1CDX2, CHGA, GHRL, AREG, TFF1, GAST
21colorectal cancer30.0ODC1, S100A8, GAST, TFF1, AREG, CDX2
22rheumatoid arthritis30.0S100A8, AREG, GHRL, IL1RN, IL8, NOS2
23arthritis30.0NOS2, IL8, IL1RN, GHRL, S100A8
24ulcerative colitis30.0TFF1, DEFB4A, IL1RN, IL8, NOS2
25sarcoidosis30.0IL1RN, DEFB4A
26gastrinoma30.0SCT, GAST, CHGA
27squamous cell carcinoma29.9ODC1, S100A8, TFF1, AREG, AKR1A1, DEFB4A
28atherosclerosis29.9CAT, SOD1, GHRL, IL1RN, IL8, NOS2
29diabetes mellitus29.9CAT, SOD1, SCT, GHRL
30neuroendocrine carcinoma29.9GAST, CHGA, CDX2
31vitiligo29.9SOD1, CAT
32obesity29.9GHRL
33neuroendocrine tumor29.9CHGA
34hepatocellular carcinoma29.7S100A8, SCT, AREG, AKR1A1, GHRL, CDX2
35leukemia29.7ODC1, CAT, S100A8, CTSW, AREG, CDX2
36acute pancreatitis29.7SOD1, SCT, IL1RN, IL8
37wermer syndrome29.7SCT, GAST, GHRL, CHGA
38pancreatic cancer29.7SCT, GAST, CHGA, CDX2
39gastroesophageal reflux disease29.7S100A8, SCT, GAST
40primary hyperparathyroidism29.7CHGA, GAST, SCT
41pituitary adenoma29.7CHGA, GHRL
42myocardial infarction29.7GHRL, AKR1A1
43type 2 diabetes mellitus29.7GHRL, SCT, SOD1, CAT
44cholera29.7TFF1, SCT, ODC1
45hyperhomocysteinemia29.7SOD1
46malt lymphoma29.7S100A8
47sarcoma29.7ODC1
48hyperparathyroidism29.7SCT, GAST, CHGA
49lymphocytic gastritis10.7
50granulomatous gastritis10.6

Graphical network of the top 20 diseases related to Gastritis:



Diseases related to gastritis

Clinical Features for Gastritis

About this section

Drugs & Therapeutics for Gastritis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Gastritis

Drug clinical trials:

Search ClinicalTrials for Gastritis

Search NIH Clinical Center for Gastritis

Search CenterWatch for Gastritis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Gastritis

About this section

Anatomical Context for Gastritis

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Gastritis:

32
Testes, T cells, Colon, Thyroid, Endothelial, B cells, Spleen, Heart, Liver, Tongue, Myeloid, Bone, Pancreas, Thymus, Lymph node, Pituitary

Animal Models for Gastritis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Gastritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537611.3ADH7, SOD1, SCT, GAST, TFF2, AKR1A1
2MP:000538711.2CTSW, GAST, TFF2, AREG, AKR1A1, IL1RN
3MP:001076811.1ODC1, CAT, S100A8, SOD1, GAST, AKR1A1
4MP:000538110.9GAST, TFF1, TFF2, AREG, GHRL, CDX2
5MP:000537910.8GAST, TFF2, AREG, CDX2

Publications for Gastritis

About this section
Sources:
50PubMed
See all sources

Articles related to Gastritis:

(show top 50)    (show all 1507)
idTitleAuthorsYear
1
Phlegmonous gastritis after esophagectomy: a case report. (23482416)
2013
2
Helicobacter pylori heterogeneity in patients with gastritis and peptic ulcer disease. (23523597)
2013
3
Gastritis cystica profunda with a long stalk. (23433598)
2013
4
Varicella zoster gastritis in an immunocompetent adult woman. (23139032)
2012
5
Histologic scoring of gastritis and gastric cancer in mouse models. (23015505)
2012
6
High chromosomal instability in adenocarcinoma of the ileum arising from multifocal gastric heterotopia with gastritis cystica profunda. (20577832)
2011
7
Lower serum level of adiponectin is associated with increased risk of endoscopic erosive gastritis. (21448696)
2011
8
Gastrointestinal bleeding caused by gastritis cystica polyposa. (22674105)
2011
9
Gastritis cystica polyposa in the operated stomach and heterotopic submucosal cysts in the unoperated stomach. (20438901)
2010
10
Age-related differences in granulomatous gastritis: a retrospective, clinicopathological analysis. (20354205)
2010
11
Role of zinc in chronic gastritis. (20698135)
2010
12
A case of eosinophilic gastritis secondary to ulcerative colitis. (20533119)
2010
13
Chronic atrophic gastritis and metachronous gastric cancer in Japanese alcoholic men with esophageal squamous cell carcinoma. (19320631)
2009
14
Potential role of human beta-defensin 1 in Helicobacter pylori-induced gastritis. (18991164)
2009
15
Remnant gastritis should be evaluated histologically rather than endoscopically. (19621726)
2009
16
LINE-1 hypomethylation is associated with increased CpG island methylation in Helicobacter pylori-related enlarged-fold gastritis. (18842996)
2008
17
Upregulation of CCL20 and recruitment of CCR6+ gastric infiltrating lymphocytes in Helicobacter pylori gastritis. (17562763)
2007
18
Difference analysis on proteome of Helicobacter pylori in patients with peptic ulcer, gastritis, and gastric cancer]. (17199978)
2006
19
Helicobacter pylori eradication in the healing of atrophic gastritis: a one-year prospective study. (16785190)
2006
20
Dominant cagA/vacA genotypes and coinfection frequency of H. pylori in peptic ulcer or chronic gastritis patients in Zhejiang Province and correlations among different genotypes, coinfection and severity of the diseases. (15788126)
2005
21
Atrophic gastritis is associated with increased sucrose permeability related to chronic inflammation. (16244483)
2005
22
Lactobacillus johnsonii La1 attenuates Helicobacter pylori-associated gastritis and reduces levels of proinflammatory chemokines in C57BL/6 mice. (16339060)
2005
23
Infiltration of CD8+ T cells containing RANTES/CCL5+ cytoplasmic granules in actively inflammatory lesions of human chronic gastritis. (14704722)
2004
24
Pepsinogen A, pepsinogen C, and gastrin as markers of atrophic chronic gastritis in European dyspeptics. (12698190)
2003
25
Flow cytometric measurement of tumor necrosis factor-related apoptosis-inducing ligand and its receptors in gastric epithelium and infiltrating mucosal lymphocytes in Helicobacter pylori-associated gastritis. (12795746)
2003
26
Compartment analysis of T cell receptor gamma--and immunoglobulin V(H) rearrangements by microdissection in patients with malt lymphoma and chronic gastritis with lymphatic hyperplasia. (12030429)
2002
27
Interleukin 1beta polymorphisms increase risk of hypochlorhydria and atrophic gastritis and reduce risk of duodenal ulcer recurrence in Japan. (12105837)
2002
28
Phosphorylation of Helicobacter pylori CagA in patients with gastric ulcer and gastritis. (12069371)
2002
29
Protective effect of green tea on the risks of chronic gastritis and stomach cancer. (11304697)
2001
30
Severity of chronic atrophic gastritis and subsequent gastric cancer occurrence: a 10-year prospective cohort study in Japan. (11078919)
2000
31
Primary gastric plasmacytoma: a rare cause of hypertrophic gastritis in an adolescent. (10512402)
1999
32
Polymorphonuclear oxidative burst after Helicobacter pylori water extract stimulation is not influenced by the cytotoxic genotype but indicates infection and gastritis grade. (10353465)
1999
33
High prevalence of atrophic body gastritis in patients with unexplained microcytic and macrocytic anemia: a prospective screening study. (10086664)
1999
34
Clinical study of weishu capsule in treating precancerous lesions of chronic atrophic gastritis]. (11475717)
1998
35
Inducible nitric oxide synthase, anti-oxidant enzymes and Helicobacter pylori infection in gastritis and gastric precancerous lesions in humans. (9926291)
1998
36
A study of accessory cells in the acquired lymphoid tissue of helicobacter gastritis. (8943810)
1996
37
Age dependent hypergastrinaemia in children with Helicobacter pylori gastritis--evidence of early acquisition of infection. (7672676)
1995
38
Corticosteroid resistance in eosinophilic gastritis--relation to in vitro eosinophil survival and interleukin 5. (8452321)
1993
39
Significance of serum markers pepsinogen I and II for chronic atrophic gastritis, peptic ulcer, and gastric cancer. (8283010)
1993
40
Role of Helicobacter pylori in gastritis and duodenitis in man. (1442334)
1992
41
Complement-fixing gastric parietal cell autoantibodies. A good marker for the identification of type A chronic atrophic gastritis. (2979621)
1988
42
Gastric cancer in chronic atrophic gastritis. Associated gastric ulcer adds no further risk. (3611683)
1987
43
Eosinophilic gastritis. (3102801)
1987
44
A double-blind study of effectiveness of hericium erinaceus pers therapy on chronic atrophic gastritis. A preliminary report. (3932005)
1985
45
Chronic atrophic gastritis in Shanghai. (6813035)
1982
46
Diffuse eosinophilic gastritis. (7097139)
1982
47
Atrophic gastritis and intestinal metaplasia in asymptomatic Hungarian and Italian populations. (7379759)
1980
48
The relationship between atrophic gastritis and gastric ulcer. (968654)
1976
49
Granulomatous gastritis, iron deficiency, vitamin B12 malabsorption and immunoglobulin deficiency. (959107)
1976
50
Studies on the pathogenesis of benign gastric ulcer: increased back diffusion of hydrogen ion in experimental atrophic gastritis. (5020675)
1972

Genetic Variations for Gastritis

About this section

Expression for genes affiliated with Gastritis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Gastritis

Search GEO for disease gene expression data for Gastritis.

Pathways for genes affiliated with Gastritis

About this section
Sources:
37NCBI BioSystems Database, 49PharmGKB, 29KEGG
See all sources

Pathways related to Gastritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Immune response Bacterial infections in normal airways
Hide members
10.8DEFB4A, IL1RN, IL8, NOS2
2
Hide members
10.8NOS2, AKR1A1, SOD1, CAT
310.7NOS2, SOD1, CAT
410.6SOD1, CAT
510.6SOD1, CAT

Compounds for genes affiliated with Gastritis

About this section
Sources:
44Novoseek, 28IUPHAR, 24HMDB, 11DrugBank, 59Tocris Bioscience, 49PharmGKB
See all sources

Compounds related to Gastritis according to GeneCards/GeneDecks:

(show top 50)    (show all 172)
idCompoundScoreTop Affiliating Genes
1cysteine4412.0CAT, IL8, IL1RN, CDX2, CHGA, DEFB4A
2histamine44 28 2413.7ODC1, IL8, IL1RN, CHGA, DEFB4A, SCT
3retinoic acid44 2412.7ODC1, ADH7, SCT, IL1RN, CHGA, AKR1A1
4nitric oxide44 11 2413.6IL8, IL1RN, CHGA, GHRL, NOS2, SOD1
5indomethacin44 59 28 1114.6IL1RN, TFF2, SCT, NOS2, AKR1A1, SOD1
6sb 20358044 5912.6IL8, AREG, NOS2, ODC1, CAT, GAST
7lactate4411.5IL8, IL1RN, CHGA, ODC1, CAT, SOD1
8adenylate4411.5ODC1, AKR1A1, NOS2, SCT, GAST, GHRL
9testosterone44 59 11 2414.5ODC1, IL1RN, TFF1, SCT, GAST, CHGA
10polyacrylamide4411.5GAST, TFF1, AREG, AKR1A1, CHGA, IL1RN
11n acetylcysteine4411.4ODC1, NOS2, CAT, SOD1, AREG, AKR1A1
12vegf4411.4GAST, GHRL, IL8, TFF1, CHGA, AREG
13arginine4411.4TFF1, AKR1A1, CHGA, SCT, SOD1, ODC1
14paraffin4411.4DEFB4A, CHGA, GHRL, TFF1, S100A8, CDX2
15zinc44 2412.4S100A8, SOD1, SCT, IL1RN, AKR1A1, ADH7
16thymidine44 2412.4GHRL, AREG, TFF1, GAST, SCT, ODC1
17isoproterenol44 1112.3SCT, GAST, AREG, ODC1, CHGA, NOS2
18creatinine4411.3S100A8, CHGA, SOD1, IL1RN, AKR1A1, GAST
19dexamethasone44 49 28 1114.3GHRL, S100A8, AREG, DEFB4A, TFF1
20omeprazole44 28 49 11 2415.3CHGA, SCT, S100A8, GAST, ADH7
21oxygen44 2412.3NOS2, IL8, S100A8, CHGA, AKR1A1, GHRL
22gsno4411.3ODC1, SOD1, AKR1A1, CAT, NOS2
23epinephrine44 11 2413.3CHGA, SCT, AREG, GHRL, IL1RN, GAST
24l-nmma4411.3GHRL, NOS2, IL1RN, SOD1, CAT
25lipid4411.3SCT, AKR1A1, GHRL, IL1RN, CHGA, SOD1
26ascorbic acid44 2412.3IL1RN, CAT, SOD1, GAST, NOS2, ODC1
27glutamate4411.2GAST, SCT, GHRL, AKR1A1
28pepsinogen4411.2SCT, GAST, CHGA, PGC
294-hydroxynonenal44 2412.2CAT, SOD1, AKR1A1, NOS2, ODC1
30tyrosine4411.2GAST, SCT, S100A8, AREG, GHRL, DEFB4A
31oxyntomodulin44 5912.2GHRL, SCT, CHGA, GAST
32clarithromycin44 1112.2S100A8, GAST, IL1RN, IL8
33h2o24411.2ODC1, CAT, TFF1, IL1RN
34ng-nitro-l-arginine4411.2GAST, SOD1, ODC1, NOS2
35serine4411.2IL8, IL1RN, GHRL, AKR1A1, SCT, S100A8
36ranitidine44 28 11 2414.2AKR1A1, ADH7, SCT
37mannitol44 1112.1SCT, ODC1, CAT
38endotoxin4411.1S100A8, GHRL, DEFB4A
39calcium44 49 11 2414.1S100A8, IL1RN, CDX2, CHGA, DEFB4A, AREG
40s-nitroso-n-acetylpenicillamine4411.1SOD1, CAT, NOS2, IL8
41cycloheximide4411.0TFF1, CAT
42bromodeoxyuridine4411.0ODC1, GAST, IL1RN, TFF1, CHGA
43estrogen4411.0DEFB4A
44alpha lipoic acid4411.0GHRL, CAT, SOD1, NOS2
45resveratrol44 59 11 2414.0TFF1, ODC1, GAST
46ptio4410.9CAT, NOS2, SOD1
47superoxide44 2411.9AKR1A1
48norepinephrine44 11 2412.8AREG, CHGA, GAST
49cimetidine44 28 1112.8AKR1A1, GAST, SCT, ADH7
50acetaldehyde44 28 2412.8CAT, GAST, AKR1A1, ADH7

GO Terms for genes affiliated with Gastritis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Gastritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.0IL8, S100A8, SOD1, TFF1, TFF2, GHRL
2extracellular regionGO:00557610.9S100A8, SOD1, SCT, GAST, GHRL, DEFB4A
3peroxisomeGO:00577710.7NOS2, SOD1, CAT

Biological processes related to Gastritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1G-protein coupled receptor signaling pathwayGO:00718610.8IL8, DEFB4A, GHRL, GAST
2digestionGO:00758610.6PGC, TFF2, TFF1
3response to ethanolGO:04547110.4S100A8, SOD1, ADH7

Products for genes affiliated with Gastritis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gastritis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet