MCID: GST044
MIFTS: 59

Gastritis malady

Gastrointestinal category

Summaries for Gastritis

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Wikipedia:64 Gastritis is inflammation of the lining of the stomach and has many possible causes. Common causes of... more...

MalaCards: Gastritis, also known as idiopathic erosive/hemorrhagic gastritis, is related to atrophic gastritis and gastric ulcer. An important gene associated with Gastritis is PGC (progastricsin (pepsinogen C)), and among its related pathways are Immune response Bacterial infections in normal airways and Doxorubicin Pathway, Pharmacokinetics. The drugs sucralfate and cat's claw preparation and the compounds cysteine and histamine have been mentioned in the context of this disorder. Related mouse phenotypes are homeostasis/metabolism and immune system.

Disease Ontology:8 A stomach disease that is an inflammation of the lining of the stomach.

Aliases & Classifications for Gastritis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 40NCIt, 57SNOMED-CT, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal


Aliases & Descriptions:

gastritis 8 10 45 61
idiopathic erosive/hemorrhagic gastritis 8 61
acute gastric mucosal erosion 8 61
other specified gastritis 8 61
chronic gastritis 8 61
acute gastritis 8 61
other specified gastritis, without mention of hemorrhage 8
acute gastritis, without mention of hemorrhage 8
acute gastritis without mention of hemorrhage 8
other specified gastritis, with hemorrhage 8
acute gastritis, with hemorrhage 8
acute gastritis with hemorrhage 8
other specified gastritis nos 8
acute haemorrhagic gastritis 8
acute hemorrhagic gastritis 8
chronic gastritis nos 8
gastritis hemorrhagic 8
gastritis unspecified 8
hemorrhagic gastritis 8
erosive gastropathy 8
erosive gastritis 8
gastritis chronic 45
gastritis erosive 45


External Ids:

Disease Ontology8 DOID:4029
NCIt40 C26780
MeSH35 D005756
ICD1025 K29.0, K29.7

Related Diseases for Gastritis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Gastritis family:

bacterial gastritis viral gastritis

Diseases related to Gastritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 309)
idRelated DiseaseScoreTop Affiliating Genes
1atrophic gastritis31.8IL1RN, CDX2, CHGA, GHRL, AKR1A1, TFF2
2gastric ulcer31.0GHRL, TFF2, TFF1, GAST, S100A8, ODC1
3duodenal ulcer30.9S100A8, SCT, GAST, IL1RN
4bile reflux30.9TFF1
5duodenitis30.8S100A8, GAST
6adenocarcinoma30.8NOS2, CDX2, CHGA, GHRL, AREG, TFF2
7duodenogastric reflux30.6GAST
8stomach cancer30.5GAST, CDX2, PGC
9celiac disease30.5GHRL
10dyspepsia30.4GHRL, GAST
11deficiency anemia30.4GHRL, AREG
12zollinger-ellison syndrome30.3SCT, GAST, CHGA
13adenoma30.2CDX2, CHGA, GHRL, AREG, TFF1, GAST
14colorectal cancer30.1ODC1, S100A8, GAST, TFF1, AREG, CDX2
15arthritis30.1NOS2, IL8, IL1RN, GHRL, S100A8
16carcinoid syndrome30.1SCT, GAST, GHRL, CHGA, CDX2
17ulcerative colitis30.1TFF1, DEFB4A, IL1RN, IL8, NOS2
18gastrinoma30.1SCT, GAST, CHGA
19squamous cell carcinoma29.9ODC1, S100A8, TFF1, AREG, AKR1A1, DEFB4A
20atherosclerosis29.9CAT, SOD1, GHRL, IL1RN, IL8, NOS2
21neuroendocrine carcinoma29.9GAST, CHGA, CDX2
22vitiligo29.9SOD1, CAT
23acute pancreatitis29.7SOD1, SCT, IL1RN, IL8
24wermer syndrome29.7SCT, GAST, GHRL, CHGA
25pancreatitis, chronic29.7AKR1A1, TFF1, SCT, SOD1
26gastroesophageal reflux disease29.7S100A8, SCT, GAST
27primary hyperparathyroidism29.7CHGA, GAST, SCT
28gastroduodenitis29.7GAST
29coronary heart disease29.7AKR1A1
30cholera29.7TFF1, SCT, ODC1
31hyperhomocysteinemia29.7SOD1
32septic shock29.7IL1RN, IL8, NOS2
33lymphoma, malt, somatic29.7S100A8
34h. pylori infection10.9
35lymphocytic gastritis10.8
36granulomatous gastritis10.7
37eosinophilic gastritis10.6
38collagenous gastritis10.6
39autoimmune atrophic gastritis10.6
40pernicious anemia10.5
41chronic erosive gastritis10.5
42necrotizing gastritis10.4
43bacterial gastritis10.4
44gastric lymphoma10.4
45alcoholic gastritis10.4
46iron deficiency anemia10.3
47gastric mucosal hypertrophy10.2
48herpetic gastritis10.2
49viral gastritis10.2
50collagenous colitis10.2

Graphical network of the top 20 diseases related to Gastritis:



Diseases related to gastritis

Clinical Features for Gastritis

Drugs & Therapeutics for Gastritis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Gastritis

Drug clinical trials:

Search ClinicalTrials for Gastritis

Search NIH Clinical Center for Gastritis

Search CenterWatch for Gastritis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Gastritis

Anatomical Context for Gastritis

Animal Models for Gastritis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Gastritis

Sources:
51PubMed
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Articles related to Gastritis:

(show top 50)    (show all 1507)
idTitleAuthorsYear
1
Helicobacter pylori and gastritis: the role of extracellular matrix metalloproteases, their inhibitors, and the disintegrins and metalloproteases--a systematic literature review. (23817928)
2013
2
Varicella gastritis in an immunocompetent child. (23276431)
2013
3
Serum anti-Helicobacter pylori immunoglobulin G titer correlates with grade of histological gastritis, mucosal bacterial density, and levels of serum biomarkers. (24329006)
2013
4
Effects of dietary calcium on Helicobacter pylori-induced gastritis in Mongolian gerbils. (24023294)
2013
5
High expression of gastrin receptor protein in injured mucosa of Helicobacter pylori-positive gastritis. (23053898)
2013
6
Complex T cell interactions contribute to Helicobacter pylori gastritis in mice. (23264048)
2013
7
Duodenal gastrinoma with multiple gastric neuroendocrine tumors secondary to chronic Helicobacter pylori gastritis. (22588069)
2012
8
The number of Helicobacter pylori CagA EPIYA C tyrosine phosphorylation motifs influences the pattern of gastritis and the development of gastric carcinoma. (22348604)
2012
9
Russell body gastritis: case report and review of the literature. (22457866)
2012
10
Two Cases of Russell Body Gastritis Treated by Helicobacter pylori Eradication. (23251890)
2012
11
Dual roles of CagA protein in Helicobacterpylori-induced chronic gastritis in mice. (21820415)
2011
12
Gastritis cystica polyposa mimicking gastric malignancy. (21475364)
2011
13
Combination of Helicobacter pylori-iceA2 and proinflammatory interleukin-1 polymorphisms is associated with the severity of histological changes in Venezuelan chronic gastritis patients. (20482626)
2010
14
The relationship between virulence factors of Helicobacter pylori and severity of gastritis in infected patients. (18465229)
2009
15
Atrophic gastritis: deficient complex I of the respiratory chain in the mitochondria of corpus mucosal cells. (18958547)
2008
16
Study on treatment principles for chronic atrophic gastritis. (18246683)
2007
17
Collagenous gastritis. (17957644)
2007
18
Plasma acylated ghrelin levels are higher in patients with chronic atrophic gastritis. (17614968)
2007
19
Correlation of Helicobacter pylori virulence genotypes vacA and cagA with histological parameters of gastritis and patient's age. (17541440)
2007
20
Cyclooxygenase-2 expression in chronic gastritis and gastric carcinoma, correlation with prognostic parameters. (18301460)
2006
21
Mt 21-42: development and validation of an automatic device proposed for the endoscopic diagnosis of Helicobacter pylori infection and atrophic gastritis. (16110218)
2005
22
Interleukin-8 promoter polymorphism increases the risk of atrophic gastritis and gastric cancer in Japan. (16284368)
2005
23
Growth factors associated with gastric mucosal hypertrophy in autoimmune gastritis. (15205119)
2004
24
Helicobacter pylori cagA, iceA and vacA status in Taiwanese patients with peptic ulcer and gastritis. (14535980)
2003
25
Distribution of vacA genotypes in Helicobacter pylori strains isolated from Brazilian adult patients with gastritis, duodenal ulcer or gastric carcinoma. (12110479)
2002
26
Discrimination between cases of duodenal ulcer and gastritis on the basis of putative virulence factors of Helicobacter pylori. (12037098)
2002
27
Helicobacter pylori genotypes in non atrophic gastritis are different of the found in peptic ulcer, premalignant lesions and gastric cancer in Colombia]. (11974526)
2002
28
Effect of lactoferrin on Helicobacter felis induced gastritis. (11908634)
2002
29
Association of the myeloperoxidase -463G-->A polymorphism with development of atrophy in Helicobacter pylori-infected gastritis. (12135010)
2002
30
Coexistence of eosinophilic gastroenteritis and Helicobacter pylori gastritis: causality versus coincidence. (11508683)
2001
31
Bile reflux gastritis and Barrett's oesophagus: further evidence of a role for duodenogastro-oesophageal reflux? (11511557)
2001
32
Helicobacter pylori and the risk and management of associated diseases: gastritis, ulcer disease, atrophic gastritis and gastric cancer. (9146793)
1997
33
Chronic atrophic gastritis and Helicobacter pylori infection in primary biliary cirrhosis: a cross-sectional study with matching. (9265572)
1997
34
Multiple gastric carcinoids and pituitary adenoma in type A gastritis. (9392350)
1997
35
Risk of gastric carcinoma in patients with mucosal dysplasia associated with atrophic gastritis: a follow up study. (9038734)
1996
36
Profile of Helicobacter pylori cytotoxin derived from two areas of Japan with different prevalence of atrophic gastritis. (9038660)
1996
37
Helicobacter pylori gastritis masquerading as gastric lymphoma. (8868361)
1995
38
Relationship between Helicobacter pylori and atrophic gastritis. (7735942)
1994
39
Serum and gastric mucosal pepsinogens in atrophic gastritis, particularly in type A gastritis associated with pernicious anemia in Japanese. (8344497)
1993
40
Animal model of human disease: lymphocytic gastritis. (8110991)
1993
41
Endoscopic gastritis and duodenitis. (1559492)
1992
42
Gastric acidity, atrophic gastritis, and calcium absorption. (1570081)
1992
43
A prospective study of atrophic gastritis and stomach cancer risk. (1483928)
1992
44
Types of atrophic gastritis in patients with primary SjAPgren's syndrome. (1998399)
1991
45
Pathology of chronic gastritis and duodenitis. (2406581)
1990
46
Changes in arterioles of the human gastric mucosa with atrophic gastritis. (2341120)
1990
47
The ratio of pepsinogen A to pepsinogen C: a sensitive test for atrophic gastritis. (2799289)
1989
48
Murine autoimmune oophoritis, epididymoorchitis, and gastritis induced by day 3 thymectomy. Autoantibodies. (3826296)
1987
49
Prevalence of autoimmune atrophic gastritis in vitiligo. (3758513)
1986
50
The diagnosis of atrophic gastritis. (4695652)
1973

Genetic Variations for Gastritis

Expression for genes affiliated with Gastritis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Gastritis

Search GEO for disease gene expression data for Gastritis.

Pathways for genes affiliated with Gastritis

Sources:
38NCBI BioSystems Database, 50PharmGKB, 30KEGG
See all sources

Pathways related to Gastritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Immune response Bacterial infections in normal airways
Hide members
10.8DEFB4A, IL1RN, IL8, NOS2
2
Hide members
10.8NOS2, AKR1A1, SOD1, CAT
310.7NOS2, SOD1, CAT
410.6SOD1, CAT
510.6SOD1, CAT

Compounds for genes affiliated with Gastritis

Sources:
45Novoseek, 29IUPHAR, 24HMDB, 11DrugBank, 60Tocris Bioscience, 50PharmGKB
See all sources

Compounds related to Gastritis according to GeneCards/GeneDecks:

(show top 50)    (show all 172)
idCompoundScoreTop Affiliating Genes
1cysteine4512.0CAT, IL8, IL1RN, CDX2, CHGA, DEFB4A
2histamine45 29 2413.7ODC1, IL8, IL1RN, CHGA, DEFB4A, SCT
3retinoic acid45 2412.7ODC1, ADH7, SCT, IL1RN, CHGA, AKR1A1
4nitric oxide45 11 2413.6IL8, IL1RN, CHGA, GHRL, NOS2, SOD1
5indomethacin45 60 29 1114.6IL1RN, TFF2, SCT, NOS2, AKR1A1, SOD1
6sb 20358045 6012.6IL8, AREG, NOS2, ODC1, CAT, GAST
7lactate4511.5IL8, IL1RN, CHGA, ODC1, CAT, SOD1
8adenylate4511.5ODC1, AKR1A1, NOS2, SCT, GAST, GHRL
9testosterone45 60 11 2414.5ODC1, IL1RN, TFF1, SCT, GAST, CHGA
10polyacrylamide4511.5GAST, TFF1, AREG, AKR1A1, CHGA, IL1RN
11n acetylcysteine4511.4ODC1, NOS2, CAT, SOD1, AREG, AKR1A1
12vegf4511.4GAST, GHRL, IL8, TFF1, CHGA, AREG
13arginine4511.4TFF1, AKR1A1, CHGA, SCT, SOD1, ODC1
14paraffin4511.4DEFB4A, CHGA, GHRL, TFF1, S100A8, CDX2
15zinc45 2412.4S100A8, SOD1, SCT, IL1RN, AKR1A1, ADH7
16thymidine45 2412.4GHRL, AREG, TFF1, GAST, SCT, ODC1
17isoproterenol45 1112.3SCT, GAST, AREG, ODC1, CHGA, NOS2
18creatinine4511.3S100A8, CHGA, SOD1, IL1RN, AKR1A1, GAST
19dexamethasone45 50 29 1114.3GHRL, S100A8, AREG, DEFB4A, TFF1
20omeprazole45 29 50 11 2415.3CHGA, SCT, S100A8, GAST, ADH7
21oxygen45 2412.3NOS2, IL8, S100A8, CHGA, AKR1A1, GHRL
22gsno4511.3ODC1, SOD1, AKR1A1, CAT, NOS2
23epinephrine45 11 2413.3CHGA, SCT, AREG, GHRL, IL1RN, GAST
24l-nmma4511.3GHRL, NOS2, IL1RN, SOD1, CAT
25lipid4511.3SCT, AKR1A1, GHRL, IL1RN, CHGA, SOD1
26ascorbic acid45 2412.3IL1RN, CAT, SOD1, GAST, NOS2, ODC1
27glutamate4511.2GAST, SCT, GHRL, AKR1A1
28pepsinogen4511.2SCT, GAST, CHGA, PGC
294-hydroxynonenal45 2412.2CAT, SOD1, AKR1A1, NOS2, ODC1
30tyrosine4511.2GAST, SCT, S100A8, AREG, GHRL, DEFB4A
31oxyntomodulin45 6012.2GHRL, SCT, CHGA, GAST
32clarithromycin45 1112.2S100A8, GAST, IL1RN, IL8
33h2o24511.2ODC1, CAT, TFF1, IL1RN
34ng-nitro-l-arginine4511.2GAST, SOD1, ODC1, NOS2
35serine4511.2IL8, IL1RN, GHRL, AKR1A1, SCT, S100A8
36ranitidine45 29 11 2414.2AKR1A1, ADH7, SCT
37mannitol45 1112.1SCT, ODC1, CAT
38endotoxin4511.1S100A8, GHRL, DEFB4A
39calcium45 50 11 2414.1S100A8, IL1RN, CDX2, CHGA, DEFB4A, AREG
40s-nitroso-n-acetylpenicillamine4511.1SOD1, CAT, NOS2, IL8
41cycloheximide4511.0TFF1, CAT
42bromodeoxyuridine4511.0ODC1, GAST, IL1RN, TFF1, CHGA
43estrogen4511.0DEFB4A
44alpha lipoic acid4511.0GHRL, CAT, SOD1, NOS2
45resveratrol45 60 11 2414.0TFF1, ODC1, GAST
46ptio4510.9CAT, NOS2, SOD1
47superoxide45 2411.9AKR1A1
48norepinephrine45 11 2412.8AREG, CHGA, GAST
49cimetidine45 29 1112.8AKR1A1, GAST, SCT, ADH7
50acetaldehyde45 29 2412.8CAT, GAST, AKR1A1, ADH7

GO Terms for genes affiliated with Gastritis

Sources:
16Gene Ontology
See all sources

Cellular components related to Gastritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.0IL8, S100A8, SOD1, TFF1, TFF2, GHRL
2extracellular regionGO:00557610.9S100A8, SOD1, SCT, GAST, GHRL, DEFB4A
3peroxisomeGO:00577710.7NOS2, SOD1, CAT

Biological processes related to Gastritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1G-protein coupled receptor signaling pathwayGO:00718610.8IL8, DEFB4A, GHRL, GAST
2digestionGO:00758610.6PGC, TFF2, TFF1
3response to ethanolGO:04547110.4S100A8, SOD1, ADH7

Products for genes affiliated with Gastritis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gastritis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet