Gastritis malady

Wikipedia: Gastritis is an inflammation of the lining of the stomach, and has many possible causes. The main acute...⁴⁴ more...

MalaCards: Gastritis, also known as other specified gastritis, is related to atrophic gastritis and peptic ulcer. An important gene associated with Gastritis is PGC (progastricsin (pepsinogen C)), and among its related pathways are IL-6 Pathway and Bacterial infections in CF airways. The drugs sucralfate and cat's claw and the compounds forskolin and ns 398 have been mentioned in the context of this disorder. Affiliated tissues include whole blood, spleen and thymus, and related mouse phenotypes are respiratory system and hematopoietic system.

Disease Ontology: A stomach disease that is an inflammation of the lining of the stomach.⁶

Aliases & Descriptions:

gastritis 6 8 32 43 other specified gastritis 6 43 chronic gastritis 6 43 acute gastritis 6 43 other specified gastritis, without mention of hemorrhage 6 idiopathic erosive/hemorrhagic gastritis (disorder) 6 acute gastritis, without mention of hemorrhage 6 acute gastritis without mention of hemorrhage 6 other specified gastritis, with hemorrhage 6 acute gastric mucosal erosion (disorder) 6 other specified gastritis nos (disorder) 6 acute hemorrhagic gastritis (disorder) 6 acute hemorrhagic gastritis (disorder) 6 other specified gastritis (disorder) 6 gastritis unspecified (disorder) 6

acute gastritis, with hemorrhage 6 chronic gastritis nos (disorder) 6 acute gastritis with hemorrhage 6 erosive gastropathy (disorder) 6 acute gastric mucosal erosion 43 chronic gastritis (disorder) 6 acute haemorrhagic gastritis 6 acute gastritis (disorder) 6 hemorrhagic gastritis 6 gastritis hemorrhagic 6 gastritis (disorder) 6 gastritis erosive 32 gastritis chronic 32 erosive gastritis 6

Diseases related to gastritis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1014)

id	Related Disease	Score	Top Affiliating Genes
1	atrophic gastritis	39.2	SCT, CHGA, S100A8, XDH, CDX2, MEN1
2	peptic ulcer	34.7	PIGG, SCT, MUC5AC, MUC5B, S100A8, XDH
3	duodenal ulcer	33.4	SCT, S100A8, IL1RN, HRH2, GAST
4	duodenitis	32.6	KIT, PCNA, CMA1, BCL2, SCT, LEP
5	alcoholism	31.8	SCT, ARSA, IL1RN, CCKBR, CCK, ALDH2
6	gastric ulcer	31.7	PCNA, VEGFA, MUC5AC, S100A8, MPO, ITGAM
7	dyspepsia	31.4	VEGFA, S100A8, ATP4A, ATP12A, CD79A, MLN
8	gastroduodenitis	30.9	VEGFA, SCT, CHGA, MUC1, MUC2, MUC5AC
9	zollinger-ellison syndrome	30.6	SCT, CHGA, CDH1, MLN, MEN1, IL6
10	gastric adenocarcinoma	30.0	BIRC5, BCL2, CHGA, MUC2, BAX, S100A8
11	juvenile rheumatoid arthritis	29.4	S100A8, IL1A, IL1RAPL2, IL1RN, IL6, HSPD1
12	duodenogastric reflux	29.1	SCT, ATP4A, ATP12A, MLN, IL8, CCK
13	arthritis	28.9	SERPINA1, IL17A, IL1A, IL1B, IL6, IL8
14	carcinoid tumors	28.7	PCNA, BCL2, SCT, CHGA, MUC1, B3GAT1
15	celiac disease	28.5	MIF, IL6, HLA-DQA1, HLA-DQB1, HLA-DRB1, TNF
16	colorectal cancer	28.5	MTHFR, MSH2, MLH1, GSTM1, GSTP1, GSTT1
17	rheumatoid arthritis	28.4	MTHFR, MIF, IL10, IL1B, IL1RN, IL2
18	gastric cancer	28.1	KIT, PCNA, SELE, SERPINA1, VEGFA, VCAM1
19	food allergy	28.1	S100A8, IL4, IL5, IGES, IGHE, TXN
20	squamous cell carcinoma	27.7	CDH1, MMP7, MKI67, GSTP1, TP73, CYP2E1
21	primary biliary cirrhosis	27.6	SCT, CD79A, CD40LG, GZMB, MBL2, ALB
22	gastrinoma	27.4	SCT, CHGA, ATP4A, ATP12A, CDKN2A, INS
23	autoimmune thyroiditis	26.9	CD59, CD55, IL4, FAS, IFNG, ICAM1
24	stevens-johnson syndrome	26.7	CD79A, MMP2, MMP9, GZMB, IL4, FAS
25	plasmacytoma	26.3	VEGFA, BCL2, MUC1, MPO, CD79A, CD34
26	carcinoma	26.1	KIT, KIR2DS5, KIR3DL2, KIR2DL1, KIR2DL3, KIR3DS1
27	dementia	24.2	SFTPD, PCNA, SERPINA1, VEGFA, VCAM1, BLVRB
28	esophagitis	23.9	KIT, SFTPD, PCNA, SELE, VEGFA, VCAM1
29	homocysteine	23.9	PCNA, SELE, VEGFA, VCAM1, LEP, MTHFR
30	acute pancreatitis	23.5	SELE, SERPINA1, VEGFA, BCL2, SCT, LEP
31	adenocarcinoma	23.4	KIT, SFTPD, PCNA, SELE, SERPINA1, VEGFA
32	esophageal squamous cell carcinoma	23.4	KIT, PCNA, SELE, VEGFA, BIRC5, PARP1
33	adenoma	23.3	KIT, PCNA, VEGFA, BIRC5, PARP1, BCL2
34	pituitary adenoma	22.9	KIT, PCNA, VEGFA, BCL2, SCT, LEP
35	obesity	22.7	KIR2DL1, KIR2DL3, KIR2DS4, KIR3DL1, SFTPD, PCNA
36	pancreatitis	22.7	KIT, PCNA, SELE, SERPINA1, VEGFA, VCAM1
37	thyroiditis	20.0	KIT, SFTPD, PCNA, SELE, SERPINA1, VEGFA
38	ulceration of vulva	15.2	SCT, MUC5AC, S100A8, XDH, CD55, AREG
39	hereditary pancreatitis	15.0	SERPINA1, SCT, MUC2, MUC5AC, MUC6, CEACAM3
40	crohn's disease	15.0	MUC2, MPO, MLN, MIF, AREG, IL10
41	factor v leiden thrombophilia	15.0	SFTPD, SERPINA1, SCT, S100A8, XDH, CD34
42	septic shock	14.9	SELE, XDH, ITGAM, MIF, IL10, IL1A
43	gastrointestinal system disease	14.9	SCT, S100A8, MLN, MIF, MADCAM1, CCKBR
44	silicosis	14.9	SFTPD, MPO, CDKN2A, MGMT, GSTP1, IL10
45	gastroesophageal reflux disease	14.8	BCL2, SCT, S100A8, ATP4A, ATP12A, CDX2
46	cystic fibrosis lung disease	14.7	SERPINA1, MUC5AC, MUC5B, FUT2, FUT3, MPO
47	periodontitis	14.6	MPO, CD209, MMP9, IL10, IL17A, IL1A
48	panic disorder	14.6	UCN, XDH, IL10, CCKBR, CCK, CAT
49	periodontal disease	14.6	S100A8, CD79A, MMP2, MMP7, MMP9, IL17A
50	neuroendocrine tumor	14.6	SCT, CHGA, CEACAM3, CDX2, MKI67, MEN1

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 cat's claw, sucralfate

MalaCards organs/tissues related to gastritis:

²²

MGI Mouse Phenotypes related to gastritis:

²⁵ (show all 24)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.2	SFTPD, FOXJ1, IL12A, AQP4, ENTPD1, CBS
2	hematopoietic system phenotype	MP:0005397	9.9	SH2D1A, KIT, PCNA, BCL10, BCL2, MSH2
3	endocrine/exocrine gland phenotype	MP:0005379	9.8	XDH, CDKN1B, CD40LG, CDX2, MEN1, IL2
4	reproductive system phenotype	MP:0005389	9.5	VEGFA, LEP, FUT2, CDKN1B, CD59, CDX2
5	embryogenesis phenotype	MP:0005380	9.3	KIT, BIRC5, PARP1, BCL10, XRCC1, CDX2
6	mortality/aging	MP:0010768	9.3	SFTPD, SELE, VEGFA, VCAM1, PARP1, BCL10
7	immune system phenotype	MP:0005387	8.9	SH2D1A, KIT, CMA1, MUC2, MUC5AC, XDH
8	nervous system phenotype	MP:0003631	8.7	KIT, PARP1, BCL10, SCT, UCN, BAX
9	adipose tissue phenotype	MP:0005375	8.6	BCL2, LEP, XDH, CDKN1B, INS, IL6
10	no phenotypic analysis	MP:0003012	8.3	PCNA, VEGFA, VCAM1, PARP1, MUC1, MTHFR
11	renal/urinary system phenotype	MP:0005367	8.2	KIT, BCL2, CHGA, BAX, ATP12A, CDKN1B
12	integument phenotype	MP:0010771	8.2	KIT, PARP1, BCL2, MUC1, XDH, MSH2
13	tumorigenesis	MP:0002006	8.0	KIT, BCL2, LEP, MUC1, MUC2, XRCC1
14	liver/biliary system phenotype	MP:0005370	7.9	KIT, VEGFA, INS, MEN1, MET, IL2
15	normal phenotype	MP:0002873	7.8	SELE, VEGFA, XRCC1, L1TD1, CD79A, CD4
16	muscle phenotype	MP:0005369	7.8	KIT, VEGFA, BCL2, LEP, BAX, S100A1
17	digestive/alimentary phenotype	MP:0005381	7.7	KIT, VEGFA, BCL2, KCNE2, LEP, MUC1
18	skeleton phenotype	MP:0005390	7.6	KIT, VEGFA, LEP, BAX, MTHFR, CDKN2A
19	growth/size phenotype	MP:0005378	7.6	KIT, SFTPD, SELE, VCAM1, PARP1, BCL2
20	behavior/neurological phenotype	MP:0005386	7.4	KIT, SELE, KCNH1, SCT, LEP, UCN
21	vision/eye phenotype	MP:0005391	6.7	KIT, SELE, VEGFA, BCL2, LEP, MUC1
22	cardiovascular system phenotype	MP:0005385	5.9	KIT, SELE, VEGFA, VCAM1, BCL2, LEP
23	homeostasis/metabolism phenotype	MP:0005376	5.6	KIT, SFTPD, SELE, VEGFA, VCAM1, BIRC5
24	cellular phenotype	MP:0005384	5.6	SH2D1A, KIT, PCNA, SELE, VEGFA, VCAM1

Articles related to gastritis:

(show top 50)    (show all 335)

id	Title	Authors	Year	Affiliating Genes
1	Relationship between gene expressions of aquaporin 3 and 4 and various degrees of spleen-stomach dampness-heat syndrome in chronic s uperficial gastritis. (20141731)	Mei W.X.... Hu B.	2010	AQP4, AQP3
2	Grb2-associated binder 1 (Gab1) genetic polymorphism, Helicobacter pylori infection, and chronic atrophic gastritis among older adul ts from Germany. (20602450)	Gao L.... Brenner H.	2010	GAB1
3	HOGG1 polymorphism in atrophic gastritis and gastric cancer after Helicobacter pylori eradication. (20845517)	Sun L.M.... Cheng J.F.	2010	OGG1
4	Targeted deletion of Kcne2 causes gastritis cystica p rofunda and gastric neoplasia. (20625512)	Roepke T.K.... Abbott G.W.	2010	KCNE2
5	CD73 is expressed by human regulatory T helper cells and suppresses proinflammatory cytokine production and Helicobacter felis-induced gastritis in mice. (19281303)	Alam M.S.... Ernst P.B.	2009	NT5E, ENTPD1
6	Role of cyclooxygenase-2 functional gene polymorphisms in Helicobacter pylori induced gastritis and gastric atrophy. (18825488)	Achyut B.R.... Mittal B.	2008	PTGS2
7	T-251A polymorphism of IL-8 relating to the development of histological gastritis and G-308A polymorphism of TNF-alpha relating to the development of macroscopic erosion. (18301299)	Szoke D.... Tulassay Z.	2008	TNF, IL8
8	Serological proteomics of gastritis: degradation of apolipoprotein A-I and alpha1-antitrypsin is a common response to inflammation irrespective of Helicobacter pylori infection. (18594986)	He Q.Y.... Chiu J.F.	2008	SERPINA1, APOA1
9	Interleukin-10 (-819 C/T) and tumor necrosis factor-alpha (-308 G/A) gene variants influence gastritis and lymphoid follicle development. (17717744)	Achyut B.R.... Mittal B.	2008	TNF, IL10
10	Correlation of Helicobacter pylori virulence genotypes vacA and cagA with histological parameters of gastritis and patient's age. (17541440)	Soltermann A.... Komminoth P.	2007	S100A8
11	Neuroimmune link in the mucosa of chronic gastritis with Helicobacter pylori infection. (16983504)	Sipos G.... FehAcr E.	2006	NPY
12	Upregulation of cathepsin W-expressing T cells is specific for autoimmune atrophic gastritis compared to other types of chronic gastritis. (16273605)	Kuester D.... Wex T.	2005	CTSW
13	Interleukin-6 polymorphism and Helicobacter pylori infection in Brazilian adult patients with chronic gastritis. (16284733)	Lobo Gatti L.... Marques Payao S.L.	2005	IL6
14	Relationship between gastric mucosal IL-8 levels and histological gastritis in patients with Helicobacter pylori infection. (16146197)	Xuan J.... Takagi A.	2005	IL8
15	Dominant cagA/vacA genotypes and coinfection frequency of H. pylori in peptic ulcer or chronic gastritis patients in Zhejiang Province and correlations among different genotypes, coinfection and severity of the diseases. (15788126)	Chen X.J.... Shen Y.F.	2005	S100A8
16	Polymorphisms of DNA repair genes XRCC1 and XRCC3, interaction with environmental exposure and risk of chronic gastritis and gastric cancer. (16425350)	Duarte M.C.... Silva A.E.	2005	XRCC1, XRCC3
17	Association between Helicobacter pylori genotype and the severity of gastritis in infected adults (15693196)	Araya J.C.... Roa J.C.	2004	S100A8
18	Functional analysis of the cag pathogenicity island in Helicobacter pylori isolates from patients with gastritis, peptic ulcer, and gastric cancer. (14742552)	Backert S.... Meyer T.F.	2004	S100A8, CTTN
19	Association of tumor necrosis factor genetic polymorphism with chronic atrophic gastritis and gastric adenocarcinoma in Chinese Han population. (15112338)	Fei B.Y.... Pena A.S.	2004	TNF
20	Defensin pattern in chronic gastritis: HBD-2 is differentially expressed with respect to Helicobacter pylori status. (12719455)	Wehkamp J.... Fellermann K.	2003	DEFA5, DEFB4A
21	Diagnosis of atrophic gastritis from a serum sample. (16481967)	Sipponen P.... Suovaniemi O.	2003	GAST
22	p16Ink4a is overexpressed in H. pylori-associated gastritis and is correlated with increased epithelial apoptosis. (12603618)	Shirin H.... Moss S.F.	2003	CDKN1B, CDKN2A
23	Mast cell chymase expression in Helicobacter pylori-associated gastritis. (14636254)	Matsuo T.... Ueda M.	2003	CMA1
24	Analysis of babA2 cagA and vacA genotypes of Helicobacter pylori in chronic gastritis and peptic ulcer (12640706)	Mao H.Y.... Ye S.J.	2003	S100A8
25	Interleukin 1beta polymorphisms increase risk of hypochlorhydria and atrophic gastritis and reduce risk of duodenal ulcer recurrence in Japan. (12105837)	Furuta T.... Sugimurra H.	2002	IL1B, IL1RN
26	Fas/CD95 is required for gastric mucosal damage in autoimmune gastritis. (12198704)	Marshall A.C.... Toh B.H.	2002	FAS
27	Protein-losing cytomegalovirus gastritis in a patient with Stevens-Johnson syndrome. (12239465)	Yoshioka M.... Kobayashi K.	2002	ALB
28	p53 Codon 72 polymorphism in gastric cancer susceptibility in patients with Helicobacter pylori-associated chronic gastritis. (12115545)	Hiyama T.... Chayama K.	2002	TP53
29	Treatment with a proton pump inhibitor promotes corpus gastritis in patients with Helicobacter pylori-infected antrum-predominant gastritis. (11856091)	Suzuki M.... Ishii H.	2002	MPO
30	Metaplasia, intraepithelial neoplasia and early cancer of the stomach are related to dedifferentiated epithelial cells defined by cytokeratin-7 expression in gastritis. (11710638)	Kirchner T.... Jung A.	2001	KRT7
31	Associations of food-cobalamin malabsorption with ethnic origin, age, Helicobacter pylori infection, and serum markers of gastritis. (11197289)	Carmel R.... Qian D.	2001	GAST
32	Composition and gene expression of the cag pathogenicity island in Helicobacter pylori strains isolated from gastric carcinoma and gastritis patients in Costa Rica. (11179371)	Occhialini A.... MAcgraud F.	2001	S100A8
33	Comparison of CXC chemokines ENA-78 and interleukin-8 expression in Helicobacter pylori-associated gastritis. (11119492)	Rieder G.... Walz A.	2001	IL8, CXCL5
34	Localisation of cyclooxygenase 1 and cyclooxygenase 2 in Helicobacter pylori related gastritis and gastric ulcer tissues in humans. (10807888)	Tatsuguchi A.... Kobayashi M.	2000	PTGS1, PTGS2
35	An 18-year follow-up study of chronic gastritis and Helicobacter pylori association of CagA positivity with development of atrophy and activity of gastritis. (10522603)	Maaroos H.I.... Villako K.	1999	S100A8
36	Clinical and histological associations of cagA and vacA genotypes in Helicobacter pylori gastritis. (9577374)	Warburton V.J.... Dixon M.F.	1998	S100A8
37	Effects of Helicobacter pylori on gastritis, pentagastrin-stimulated gastric acid secretion, and meal-stimulated plasma gastrin release in the absence of peptic ulcer disease. (9707051)	Hurlimann S.... Halter F.	1998	GAST
38	Helicobacter pylori and the risk and management of associated diseases: gastritis, ulcer disease, atrophic gastritis and gastric cancer. (9146793)	Kuipers E.J.	1997	S100A8
39	Endocrine cell growths in atrophic body gastritis. Critical evaluation of a histological classification. (9349238)	Bordi C.... Delle Fave G.	1997	GAST
40	Serum and gastric luminal epidermal growth factor in Helicobacter pylori-associated gastritis and peptic ulcer disease. (9398872)	Lynch D.A.... Quirke P.	1996	EGF
41	Enteroinsular hormones in chronic gastritis with secretory insufficiency (7483547)	Mishchuk V.H.... NeA-ko I.e.M.	1995	SCT
42	Importance in diagnosis of gastritis of detection by PCR of the cagA gene in Helicobacter pylori strains isolated from children. (8586721)	Husson M.O.... Leclerc H.	1995	S100A8
43	Role of Helicobacter pylori infection in gastro-duodenal secretion and in pathogenesis of peptic ulcer and gastritis. (7841447)	Konturek P.C.... Konturek S.J.	1994	GAST
44	Enterochromaffin-like (ECL) cells and their growths: relationships to gastrin, reduced acid secretion and gastritis. (7682874)	Solcia E.... Villani L.	1993	GAST
45	The gastrin and pepsinogen levels of patients with chronic atrophic gastritis and duodenal ulcer (8191737)	Valenkevich L.N.	1993	GAST
46	Effect of beta-carotene supplementation on the activity of ornithine decarboxylase (ODC) in stomach mucosa of patients with chronic atrophic gastritis. (8428179)	Bukin Y.V.... Nechipai A.M.	1993	ODC1
47	Hypergastrinemia and type A gastritis in Basedow's disease (1404986)	Kaise M.... Nishimura M.	1992	GAST
48	Natural history of gastritis and its relationship to peptic ulcer disease. (1397747)	Sipponen P.	1992	GAST
49	Comparison of the efficacy of omeprazole/bismuth subcitrate or triple therapy in Helicobacter pylori gastritis. A prospective controlled study (1411403)	Bertschinger P.... HAocki W.H.	1992	GAST
50	Is Helicobacter pylori associated hypergastrinaemia due to the bacterium's urease activity or the antral gastritis? (1752456)	Chittajallu R.S.... McColl K.E.	1991	GAST

Genes related to gastritis according to GeneCards:

(show top 50)    (show all 255)

id	Symbol	Description	Score	GeneCards Section Context
1	PGC	progastricsin (pepsinogen C)	11.1	Summaries, Publications
2	GAST	gastrin	11.0	Publications
3	S100A8	S100 calcium binding protein A8	11.0	Publications
4	ODC1	ornithine decarboxylase 1	11.0	Publications
5	SCT	secretin	11.0	Publications
6	CDX2	caudal type homeobox 2	11.0	Publications
7	GHRL	ghrelin/obestatin prepropeptide	11.0	Publications
8	IL1RN	interleukin 1 receptor antagonist	11.0	Publications
9	IL8	interleukin 8	11.0	Publications
10	NOS2	nitric oxide synthase 2, inducible	11.0	Publications
11	TFF2	trefoil factor 2	11.0	Functions
12	ADH7	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide	11.0	Publications
13	AREG	amphiregulin	11.0	Publications
14	AKR1A1	aldo-keto reductase family 1, member A1 (aldehyde reductase)	11.0	Publications
15	CHGA	chromogranin A (parathyroid secretory protein 1)	11.0	Publications
16	TFF1	trefoil factor 1	11.0
17	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	11.0	Publications
18	CAT	catalase	11.0	Publications
19	SOD1	superoxide dismutase 1, soluble	11.0	Publications
20	MUC6	mucin 6, oligomeric mucus/gel-forming	11.0	Publications
21	DEFB4A	defensin, beta 4A	11.0	Publications
22	MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	11.0	Publications
23	MEN1	multiple endocrine neoplasia I	11.0	Publications
24	CCKBR	cholecystokinin B receptor	11.0	Publications
25	HBEGF	heparin-binding EGF-like growth factor	11.0	Publications
26	PTGS1	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	11.0	Publications
27	IL1B	interleukin 1, beta	11.0	Publications
28	TGFA	transforming growth factor, alpha	11.0	Publications
29	MUC1	mucin 1, cell surface associated	11.0	Publications
30	MET	met proto-oncogene (hepatocyte growth factor receptor)	11.0
31	XDH	xanthine dehydrogenase	11.0	Publications
32	PTPN11	protein tyrosine phosphatase, non-receptor type 11	11.0
33	PCNA	proliferating cell nuclear antigen	11.0	Publications
34	FOXJ1	forkhead box J1	11.0	Publications
35	CTSW	cathepsin W	11.0	Publications
36	PGA3	pepsinogen 3, group I (pepsinogen A)	11.0	Publications
37	NDUFS5	NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase)	11.0	Publications
38	DEFA5	defensin, alpha 5, Paneth cell-specific	11.0	Publications
39	SLC25A11	solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11	11.0
40	DEFB1	defensin, beta 1	11.0	Publications
41	CXCL5	chemokine (C-X-C motif) ligand 5	11.0	Publications
42	MUC5B	mucin 5B, oligomeric mucus/gel-forming	11.0	Publications
43	FUT3	fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)	11.0	Publications
44	AICDA	activation-induced cytidine deaminase	11.0	Publications
45	UCN	urocortin	11.0
46	FUT2	fucosyltransferase 2 (secretor status included)	11.0	Publications
47	PTGES	prostaglandin E synthase	11.0	Publications
48	CXCL2	chemokine (C-X-C motif) ligand 2	11.0	Publications
49	CCL20	chemokine (C-C motif) ligand 20	11.0	Publications
50	IL12A	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	11.0	Publications

Pathways related to gastritis according to GeneDecks:

(show top 50)    (show all 128)

id	Pathway	Score	Top Affiliating Genes
1	IL-6 Pathway36	11.2	BAX, IL10, IL12A, IL3, IL4, IL5
2	Bacterial infections in CF airways41	11.1	SFTPD, MUC1, IKBKB, TLR2, TLR5, DEFB4A
3	RAR-Gamma-RXR-Alpha Degradation36	10.8	IL12A, IL2, IL3, CCL20, CCL25, CCL28
4	Leishmaniasis20	10.8	ITGAM, IL10, IL12A, IL1A, IL1B, IL4
5	MIF Mediated Glucocorticoid Regulation36	10.7	BCL2, BAX, MIF, IL10, IL12A, IL1A
6	Antigen processing and presentation20	10.7	KIR2DS3, KIR2DS5, KIR3DL2, KIR3DL3, KIR2DL1, KIR2DL3
7	MIF Regulation of Innate Immune Cells36	10.7	BCL2, BAX, MIF, IL10, IL12A, IL1A
8	NF-KappaB Family Pathway36	10.7	BCL10, AREG, MET, IL1A, IL1B, IL2
9	Chagas disease (American trypanosomiasis)20	10.7	IL10, IL12A, IL1B, IL6, FAS, CCL3
10	NF-KappaB (p50-p65) Pathway36	10.6	AREG, MET, IL1A, IL1B, IL2, IL3
11	Intestinal immune network for IgA production20	10.6	CD40LG, ITGB7, IL10, IL2, IL4, IL5
12	Rheumatoid arthritis20	10.6	VEGFA, ATP6V1G1, IL17A, IL1A, IL1B, IL6
13	all-trans-Retinoic Acid Signaling in Brain36	10.6	BCL2, BAX, IL10, IL12A, IL1A, IL1B
14	STAT3 Pathway36	10.6	BCL2, BAX, CD4, MET, IL10, IL12A
15	Akt Signaling36	10.6	KIT, CD4, ITGAM, ITGAX, MET, IL10
16	Tuberculosis20	10.6	BCL10, BCL2, BAX, CD209, ITGAM, ITGAX
17	PAK Pathway36	10.4	KIT, BCL2, BAX, AREG, MET, IL10
18	Malaria20	10.4	SELE, VCAM1, CD40LG, GYPC, MET, IL10
19	Immune response MIF in innate immunity response10	10.3	MIF, IL1B, IL6, IL8, IKBKB, IFNG
20	Regulation of eIF4 and p70S6K36	10.3	BAX, CD4, ITGAM, ITGAX, ITGB7, IL12A
21	PEDF Induced Signaling36	10.2	BCL2, BAX, IL10, IL12A, IL1A, IL1B
22	Immune response_MIF in innate immunity response41	10.2	MIF, IL1B, IL6, IL8, IKBKB, IFNG
23	Antioxidant Action of Vitamin-C36	10.2	KIT, BCL2, BAX, CD4, AREG, MET
24	Graft-versus-host disease20	10.1	KIR3DL2, KIR2DL1, KIR2DL3, KIR3DL1, KIR2DL5A, KIR2DL2
25	MAPK Family Pathway36	10.1	BCL2, BAX, CD4, AREG, MET, IL10
26	Immune response_Bacterial infections in normal airways41	10.1	IL1B, IKBKB, IFNG, NOS2, NFKBIA, TLR5
27	Natural killer cell mediated cytotoxicity20	10.0	SH2D1A, KIR2DS3, KIR2DS5, KIR3DL2, KIR2DL1, KIR2DL3
28	Immune System38	10.0	KIR2DS5, KIR3DL2, KIR2DL1, KIR2DL3, KIR2DL4, KIR3DS1
29	TGF-Beta Pathway36	10.0	BCL2, BAX, CD4, CDH1, AREG, MET
30	Cytokine Network36	10.0	IL10, IL12A, IL1A, IL1B, IL2, IL3
31	Tec Kinases Signaling36	10.0	BCL2, BAX, CD4, ITGAM, ITGAX, ITGB7
32	Rho Family GTPases36	10.0	KIT, BCL2, BAX, CDH1, ITGAM, ITGAX
33	PGC1Alpha Pathway36	9.9	BCL2, BAX, CD4, IL12A, IL1A, IL1B
34	ERK Signaling36	9.9	KIT, ITGAM, ITGAX, ITGB7, AREG, IL10
35	Molecular Mechanisms of Cancer36	9.9	BCL2, BAX, CDKN1B, CDKN2A, CD4, CDH1
36	p38 Signaling36	9.8	KIT, BCL2, BAX, CD4, AREG, MET
37	Glucocorticoid Receptor Signaling36	9.8	BCL2, BAX, CD4, IL10, IL12A, IL1A
38	Endothelin-1 Signaling Pathway36	9.8	KIT, IL10, IL12A, IL1A, IL1B, IL2
39	NFAT Signaling and Lymphocyte Interactions36	9.7	BCL2, BAX, CD4, IL12A, IL1A, IL2
40	Immune response MIF-mediated glucocorticoid regulation10	9.6	VCAM1, MIF, IL2, IL6, IL8, IKBKB
41	Immune response_MIF-mediated glucocorticoid regulation41	9.6	VCAM1, MIF, IL2, IL6, IL8, IKBKB
42	Cytokine-cytokine receptor interaction20	9.4	KIT, VEGFA, LEP, CD40LG, MET, IL10
43	Colorectal Cancer Metastasis36	9.3	BIRC5, BAX, MSH2, CDH1, MMP2, MMP7
44	Allograft rejection20	9.3	CD40LG, GZMB, IL10, IL12A, IL2, IL4
45	SOCS Pathway36	9.2	BCL2, BAX, CD4, INS, IL10, IL12A
46	JNK Pathway36	9.0	KIT, BCL2, BAX, CD4, AREG, IL2
47	Type I diabetes mellitus20	8.9	GZMB, INS, IL12A, IL1A, IL1B, IL2
48	JAK-STAT Pathway36	8.9	KIT, BCL2, BAX, CD4, AREG, MET
49	Pathways in cancer20	8.4	VEGFA, BIRC5, BCL2, BAX, MSH2, CDKN1B
50	Pancreatic Adenocarcinoma36	8.2	KIT, BIRC5, BCL2, CDKN1B, CDKN2A, MMP2

Compounds related to gastritis according to GeneDecks:

(show top 50)    (show all 468)

id	Compound	Score	Top Affiliating Genes
1	forskolin32 42 9 9	14.3	SCT, CHGA, MUC1, MUC2, UCN, CDKN1B
2	ns 39832 42	12.1	PCNA, PARP1, CDKN1B, IL17A, IL1A, IL1B
3	ribonucleic acid32	11.0	KIT, CHGA, MUC1, MUC5AC, UCN, MMP2
4	polyacrylamide32	11.0	SERPINA1, CHGA, S100A8, CDH1, CD55, MLH1
5	egcg32	11.0	IL1A, CCL5, IKBKAP, CAT, ERBB3, PTGS1
6	leukotriene b432 42 18	12.9	MPO, ITGAM, ITGAX, MMP9, IL1A, IL1B
7	cyclophosphamide32 34 9 9	13.9	MBL2, LTF
8	methylcellulose32	10.7	KIT, CD59, CD34, CDH1, IL1A, IL3
9	glutamine32	10.6	KIT, SFTPD, PCNA, SCT, XRCC1, CDKN1B
10	hyaluronic acid32 18	11.6	MUC1, CDH1, GZMB, CALB2, PTGS1, RNASE3
11	h2o232	10.5	SERPINA1, LEP, XDH, MPO, CD79A, ITGAM
12	omeprazole32 42 34 9 18 9	15.5	SCT, CHGA, S100A8, ATP4A, MLN, CCKBR
13	carbohydrates32	10.4	SFTPD, SELE, VCAM1, MUC2, MUC5AC, FUT2
14	ccl332	10.4	MMP9, IL10, IL1A, IL1B, IL6, IL8
15	nifedipine32 9 9	12.2	SELE, LEP, CHGA, MMP9, MLN, IL1A
16	ag 147832	10.2	MUC5AC, CDKN1B, MMP2, MMP7, MMP9, AREG
17	methacholine32 9 9	12.1	MPO, CD79A, IL17A, IL4, IL5, IL8
18	vitamin a32 9 18 9	12.8	SERPINA1, BIRC5, LEP, MLH1, GSTM1, FAS
19	biotin32 9 18 9	12.7	PCNA, SCT, MUC1, S100A1, MSH2, CD79A
20	cyclosporin a32 42	10.6	LEP, MTHFR, CD59, CD83, CD55, CD46
21	polysaccharide32	9.6	SFTPD, SELE, SERPINA1, VCAM1, CD209, CD79A
22	anti-fungal32	9.5	SFTPD, CHGA, CD79A, CDKN2A, CD40LG, IL5
23	atp32	9.4	KIT, KIR3DL1, BLVRB, BIRC5, PARP1, SCT
24	acetylcholine32 9 18 9	12.3	BLVRB, SCT, LEP, CHGA, UCN, S100A1
25	heparin32 9 18 9	12.3	SERPINA1, CMA1, B3GAT1, MPO, CD79A, CD4
26	epinephrine32 9 18 9	12.2	SELE, SCT, LEP, CHGA, CD79A, ITGAM
27	p00232	9.2	KIT, BIRC5, LEP, CHGA, MTHFR, XRCC1
28	vitamin d32	9.2	CHGA, MTHFR, CD79A, CDX2, CDH1, ITGAM
29	resveratrol32 9 18 9	12.1	PCNA, VEGFA, BIRC5, PARP1, BCL2, BAX
30	octreotide32 42 9 9	12.1	VEGFA, SCT, CHGA, MPO, MMP2, MLN
31	melphalan32 9 9	11.1	BIRC5, XRCC3, CD79A, MMP2, MGMT, GSTP1
32	cysteine32	9.1	KIR2DS4, SFTPD, PCNA, SERPINA1, CMA1, PARP1
33	histamine32 18	10.1	KIT, SFTPD, PCNA, SELE, VCAM1, CMA1
34	cytarabine32 34 9 9	12.1	KIT, PCNA, BCL2, MUC1, BAX, MPO
35	norepinephrine32 9 18 9	12.1	SELE, VCAM1, SCT, LEP, CHGA, UCN
36	ibuprofen32 9 18 9	11.9	VCAM1, LEP, MMP2, IL10, IL1B, IL1RN
37	cholesterol32 9 18 9	11.8	SFTPD, SELE, SERPINA1, VCAM1, BIRC5, CMA1
38	gefitinib32 34 9 9	11.7	KIT, SFTPD, VEGFA, BIRC5, CDKN1B, CDH1
39	doxorubicin32 34 9 9	11.6	KIT, SELE, PARP1, CEACAM3, MSH2, CDKN1B
40	thyroxine32 18	9.5	PCNA, SCT, LEP, CEACAM3, CD79A, CD40LG
41	irinotecan32 34 9 9	11.5	KIT, VEGFA, PARP1, BAX, MTHFR, XRCC1
42	etoposide32 42 9 9	11.5	PCNA, SELE, BIRC5, PARP1, BCL2, CHGA
43	troglitazone32 42 9 9	11.3	SELE, VCAM1, BIRC5, BCL2, LEP, BAX
44	rapamycin32 42	9.2	KIT, VEGFA, CD46, GZMB, INS, MET
45	alanine32	8.0	PCNA, SELE, VCAM1, BIRC5, BCL10, B3GAT1
46	prednisolone32 9 9	9.9	SFTPD, VCAM1, MPO, CD79A, ITGAM, MMP2
47	paclitaxel32 34 9 9	10.8	KIT, PCNA, VEGFA, BIRC5, PARP1, BCL2
48	cisplatin32 34 9 9	10.5	PCNA, VEGFA, BIRC5, PARP1, BCL2, LEP
49	dexamethasone32 42 34 9 9	10.8	SFTPD, PCNA, VEGFA, VCAM1, BIRC5, PARP1
50	cyclic amp32 18	INF	SFTPD, KCNH1, SCT, CHGA, UCN, CDKN1B

Cellular components related to gastritis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	integral to plasma membrane	GO:005887	10.2	HLA-DRB1, HLA-DQA1, HLA-C, HLA-B, HLA-A, ERBB3
2	cell surface	GO:009986	10.1	TNF, NOD2, ABCB1, HBEGF, TLR2, TGFA
3	Golgi lumen	GO:005796	10.1	TGFB1, DEFB1, DEFB4A, DEFA5, INS, MUC6
4	secretory granule	GO:030141	9.6	DEFA5, LTF, GHRL, GKN1, HSPD1, APOA1
5	membrane raft	GO:045121	9.3	TNF, EGFR, TLR4, PRNP, SI, IKBKB
6	extracellular region	GO:005576	8.9	IFNG, APOA1, IL8, IL6, IL5, IL3
7	external side of plasma membrane	GO:009897	8.5	ADA, AQP4, IL4, IL17A, ITGAX, CD83
8	plasma membrane	GO:005886	8.0	HLA-DQA1, HLA-DQB1, HLA-DRB1, TNF, PTGS1, CYSLTR1
9	extracellular space	GO:005615	7.5	SST, AMH, IFNG, CCL5, CCL19, CCK

Biological processes related to gastritis according to GeneDecks:

(show top 50)    (show all 51)

id	Name	GO ID	Score	Top Affiliating Genes
1	chemotaxis	GO:006935	11.4	CYSLTR1, DEFB1, DEFB4A, CXCL1, CXCL2, CXCL5
2	inflammatory response	GO:006954	11.3	IKBKB, ADORA2A, LY96, CALCA, TP73, TNF
3	positive regulation of interleukin-6 production	GO:032755	11.3	NOD2, TLR2, TLR4, TLR9, NOD1, TNF
4	positive regulation of ERK1 and ERK2 cascade	GO:070374	11.3	TNF, NOD1, NOD2, TLR4, TFF2, CCL19
5	positive regulation of JNK cascade	GO:046330	11.2	TLR9, TLR4, NOD2, NOD1, TNF, CCL19
6	digestion	GO:007586	11.1	PGC, MUC5AC, CCKBR, GKN1, SST, TFF1
7	lipopolysaccharide-mediated signaling pathway	GO:031663	11.1	LY96, TGFB1, TLR4, TLR2, NFKBIA, TNF
8	defense response to Gram-positive bacterium	GO:050830	11.0	TLR2, LTA, NOD1, TNF, MBL2, IL6
9	activation of MAPK activity	GO:000187	11.0	NOD1, NOD2, TLR4, TGFA, SOD1, PTPN11
10	response to glucocorticoid stimulus	GO:051384	10.9	IL10, IL1B, IL1RN, IL6, FAS, CCL5
11	innate immune response	GO:045087	10.9	NOD2, NFKBIA, RNASE7, TLR2, TLR4, TLR5
12	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	10.9	NOD1, NOD2, TLR4, TLR9, ADIPOQ, TNF
13	immune response	GO:006955	10.9	KIR2DS5, MADCAM1, CCR6, CCL20, CCL25, CCL28
14	defense response to bacterium	GO:042742	10.9	LTF, TLR4, TLR9, DEFB1, DEFB4A, DEFA5
15	response to lipopolysaccharide	GO:032496	10.8	PTGS2, LTA, TLR4, NKX2-1, LY96, CCR7
16	response to oxidative stress	GO:006979	10.8	KRT1, TLR4, PRNP, OGG1, GAB1, PTGS1
17	positive regulation of interleukin-8 production	GO:032757	10.7	ADIPOQ, TLR9, TLR5, TLR4, TLR2, CALCA
18	positive regulation of interleukin-10 production	GO:032733	10.7	TLR9, TLR4, NOD2, HSPD1, IL4, CD83
19	response to organic cyclic compound	GO:014070	10.7	TIMP3, PTGS2, ICAM1, AMH, CCL19, IL4
20	aging	GO:007568	10.7	ADA, SI, TGFB1, TIMP3, TIMP1, PTGS1
21	cellular defense response	GO:006968	10.7	KIR2DL4, BCL10, IL4, CCR6, LY96, ADORA2A
22	positive regulation of dendritic cell antigen processing and presentation	GO:002606	10.6	CCL21, CCR7, CCL19, NOD1, NOD2
23	positive regulation of NF-kappaB import into nucleus	GO:042346	10.6	TLR9, TLR4, TLR2, TNF, CCL19, IL1B
24	negative regulation of cell proliferation	GO:008285	10.6	PTGES, PTGS2, SST, PDX1, TGFB1, CXCL1
25	positive regulation of interferon-gamma production	GO:032729	10.5	TLR4, LTA, TNF, HSPD1, IL2, IL1B
26	regulation of blood pressure	GO:008217	10.5	CHGA, CD34, CALCA, PTGS2, PTGS1, ACE
27	positive regulation of tumor necrosis factor production	GO:032760	10.4	CCL19, IFNG, NOD1, NOD2, TLR2, TLR4
28	positive regulation of interleukin-12 production	GO:032735	10.4	TLR9, TLR4, TLR2, HSPD1, IFNG, CCL19
29	humoral immune response	GO:006959	10.3	LTF, LTA, TNF, IFNG, CCR6, IL6
30	positive regulation of NF-kappaB transcription factor activity	GO:051092	10.2	NOD1, NOD2, NFKBIA, TLR2, TLR4, TLR9
31	response to ethanol	GO:045471	10.2	ADIPOQ, BCL2, S100A8, MMP9, MGMT, IL4
32	negative regulation of growth of symbiont in host	GO:044130	10.1	TLR2, LTA, TNF, IFNG, MBL2, IL10
33	positive regulation of T cell proliferation	GO:042102	10.1	IFNG, CCL5, CCL19, IL6, IL4, IL1B
34	leukocyte cell-cell adhesion	GO:007159	10.0	CALCA, ICAM1, CCL5, CD40LG, CD209, VCAM1
35	regulation of immune response	GO:050776	10.0	KIR2DS2, KIR2DS1, KIR2DL2, VCAM1, CD40LG, CD34
36	positive regulation of mitosis	GO:045840	10.0	EGF, TNF, IL1B, IL1A, MET, INS
37	positive regulation of B cell proliferation	GO:030890	9.9	ADA, BCL2, CD40LG, MIF, IL2, IL4
38	cell-cell signaling	GO:007267	9.9	CCL5, AMH, CALCA, GHRH, TXN, SST
39	interferon-gamma-mediated signaling pathway	GO:060333	9.9	PTPN11, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-C, HLA-B
40	cell cycle arrest	GO:007050	9.9	TP53, TP53INP1, TP73, TGFB1, PRNP, IFNG
41	anti-apoptosis	GO:006916	9.9	IKBKB, GHRL, TNF, TERT, NFKBIA, TGFA
42	positive regulation of protein kinase B signaling cascade	GO:051897	9.9	TGFB1, HBEGF, EGFR, TNF, CCL19, CCR7
43	response to hypoxia	GO:001666	9.8	ERCC2, TNF, NOS2, LTA, TLR4, TGFB1
44	cytokine-mediated signaling pathway	GO:019221	9.8	HLA-B, HLA-C, HLA-DQA1, HLA-DQB1, HLA-DRB1, PTPN11
45	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.6	CCK, TP53, TLR4, ADIPOQ, IL6, IL5
46	response to toxin	GO:009636	9.5	TLR4, IKBKB, CCL5, CCL3, FAS, MGMT
47	response to drug	GO:042493	9.3	XRCC1, MSH2, ATP4A, CDH1, MMP7, MMP9
48	positive regulation of nitric oxide biosynthetic process	GO:045429	9.3	TLR4, TLR2, EGFR, PTGS2, TNF, ICAM1
49	positive regulation of cell proliferation	GO:008284	8.5	GHRH, ODC1, PDX1, EGF, EGFR, TIMP1
50	negative regulation of apoptotic process	GO:043066	8.3	CAT, GHRL, ERCC2, TP53, TNF, KRT18

Molecular functions related to gastritis according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	chemokine activity	GO:008009	11.0	CXCL5, CXCL2, CXCL1, CCL5, CCL19, CCL21
2	growth factor activity	GO:008083	10.1	AMH, GKN1, EGF, HBEGF, TGFA, TGFB1
3	enzyme binding	GO:019899	9.4	CYP2E1, NOD2, NFKBIA, EGFR, TGFB1, SLPI
4	cytokine activity	GO:005125	9.3	IL4, IL5, IL6, IFNG, TNF, LTA
5	hormone activity	GO:005179	9.2	GAST, ADIPOQ, SST, CALCA, AMH, CCK
6	transmembrane signaling receptor activity	GO:004888	9.0	TLR4, TLR2, EGFR, ERBB2, ERBB3, ICAM1
7	identical protein binding	GO:042802	8.7	TNF, NOD1, NFKBIA, SKP2, EGFR, SYP
8	protein binding	GO:005515	INF	ALB, TERT, PTGES3, PTPN11, CTTN, NOD1