MCID: GST044
MIFTS: 56

Gastritis malady

Gastrointestinal diseases category

Aliases & Classifications for Gastritis

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 38NCIt, 55SNOMED-CT, 33MeSH, 25ICD10
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Gastritis, Aliases & Descriptions:

Name: Gastritis 9 11 43 60
Acute Gastritis, Without Mention of Hemorrhage 9 60
Idiopathic Erosive/hemorrhagic Gastritis 9 60
Acute Gastric Mucosal Erosion 9 60
Hemorrhagic Gastritis 9 60
Erosive Gastropathy 9 60
Chronic Gastritis 9 60
Acute Gastritis 9 60
Acute Gastritis Without Mention of Hemorrhage 9
Acute Gastritis, with Hemorrhage 9
 
Acute Gastritis with Hemorrhage 9
Acute Haemorrhagic Gastritis 9
Acute Hemorrhagic Gastritis 60
Gastritis Hemorrhagic 9
Chronic Gastritis Nos 9
Gastritis Unspecified 9
Gastritis Chronic 43
Gastritis Erosive 43
Erosive Gastritis 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology9 DOID:4029
NCIt38 C26780
MeSH33 D005756
ICD1025 K29.0, K29.7

Summaries for Gastritis

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Wikipedia:63 Gastritis is inflammation of the lining of the stomach and has many possible causes. The most common... more...

MalaCards based summary: Gastritis, also known as acute gastritis, without mention of hemorrhage, is related to duodenitis and pernicious anemia. An important gene associated with Gastritis is PGC (progastricsin (pepsinogen C)), and among its related pathways are Immune response MIF mediated glucocorticoid regulation and Detoxification of Reactive Oxygen Species. The drugs sucralfate and cat's claw preparation and the compounds diphenyliodonium and ptio have been mentioned in the context of this disorder. Affiliated tissues include testes, t cells and colon, and related mouse phenotypes are digestive/alimentary and tumorigenesis.

Disease Ontology:9 A stomach disease that is an inflammation of the lining of the stomach.

Related Diseases for Gastritis

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Diseases in the Gastritis family:

Bacterial Gastritis Viral Gastritis

Diseases related to Gastritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 273)
idRelated DiseaseScoreTop Affiliating Genes
1duodenitis31.8GAST, S100A8
2pernicious anemia31.6GAST
3duodenogastric reflux31.5GAST
4duodenal ulcer31.2IL1RN, GAST, S100A8, SCT
5dyspepsia31.2GAST, GHRL
6gastric ulcer31.0TFF1, GAST, ODC1, S100A8, GHRL
7stomach cancer31.0GAST, CDX2, PGC
8esophagitis30.9CAT, S100A8, GAST, CDX2
9peptic ulcer disease30.9PGC, SCT, S100A8, IL8, GAST
10zollinger-ellison syndrome30.9GAST, CHGA, SCT
11gastroesophageal reflux30.8GAST, SCT, S100A8
12collagenous colitis30.7NOS2
13gastrinoma30.6SCT, CHGA, GAST
14neuroendocrine tumor30.5CDX2, GAST, CHGA
15multiple endocrine neoplasia 130.4CHGA, GAST
16atrophic gastritis30.3ADH7, TFF1, SCT, ODC1, SOD1, CDX2
17tubular adenocarcinoma30.3CDX2, CHGA
18primary hyperparathyroidism30.2GAST, CHGA, SCT
19hyperparathyroidism30.2SCT, CHGA, GAST
20colitis30.2NOS2, IL1RN, TFF1, DEFB4A, IL8
21cholera30.0SCT, TFF1, ODC1
22adenocarcinoma30.0NOS2, TFF1, SCT, GAST, ODC1, CHGA
23pancreatic cancer30.0SCT, GAST, CDX2, TFF1
24rheumatoid arthritis30.0S100A8, GHRL, IL8, IL1RN, NOS2
25arthritis29.9S100A8, IL1RN, NOS2, GHRL, IL8
26carcinoid syndrome29.9GHRL, SCT, CHGA, CDX2, GAST
27gastric adenocarcinoma29.9DEFB4A, TFF1, GAST, ODC1, CHGA, IL1RN
28colorectal cancer29.8NOS2, GAST, TFF1, CDX2, ODC1
29adenoma29.7TFF1, SCT, ODC1, GHRL, CDX2, S100A8
30ulcerative colitis29.7IL8, NOS2, DEFB4A, IL1RN, TFF1
31coronary artery disease29.6IL1RN, SOD1, NOS2
32acute pancreatitis29.5IL1RN, IL8, SCT, SOD1
33inflammatory bowel disease29.5DEFB4A, IL1RN, IL8, S100A8, NOS2, SCT
34atherosclerosis29.0SOD1, IL1RN, IL8, GHRL, CAT, NOS2
35lymphocytic gastritis10.8
36granulomatous gastritis10.7
37eosinophilic gastritis10.6
38bile reflux10.6
39collagenous gastritis10.6
40chronic erosive gastritis10.6
41sleeping sickness10.5ODC1
42necrotizing gastritis10.5
43autoimmune atrophic gastritis10.5
44acinar cell carcinoma10.4CHGA, GAST
45gastroparesis10.4GAST, GHRL
46islet cell tumor10.4GAST, CHGA
47somatostatinoma10.4CHGA, GAST
48endocrine gland cancer10.4CHGA, GAST
49h. pylori infection10.4
50alcoholic gastritis10.4

Graphical network of the top 20 diseases related to Gastritis:



Diseases related to gastritis

Symptoms for Gastritis

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Drugs & Therapeutics for Gastritis

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Drug clinical trials:

Search ClinicalTrials for Gastritis

Search NIH Clinical Center for Gastritis

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Gastritis

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Anatomical Context for Gastritis

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MalaCards organs/tissues related to Gastritis:

31
Testes, T cells, Colon, Thyroid, Endothelial, Spleen, B cells, Heart, Liver, Myeloid, Tongue, Neutrophil, Bone, Lymph node, Thymus, Pancreas, Pituitary

Animal Models for Gastritis or affiliated genes

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MGI Mouse Phenotypes related to Gastritis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.4CDX2, NOS2, GAST, GHRL, TFF1
2MP:00020067.9TFF1, CAT, GAST, NOS2, CDX2
3MP:00053797.5TFF1, SOD1, CHGA, GHRL, GAST, NOS2
4MP:00053766.4CDX2, TFF1, SCT, SOD1, ADH7, CHGA
5MP:00107686.3CHGA, ADH7, SOD1, ODC1, IL1RN, CAT

Publications for Gastritis

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Articles related to Gastritis:

(show top 50)    (show all 1571)
idTitleAuthorsYear
1
Long-term treatment of patients with a history of ulcerative colitis who develop gastritis and pan-enteritis after colectomy. (22858512)
2013
2
Phlegmonous gastritis after esophagectomy: a case report. (23482416)
2013
3
Autoimmune gastritis mediated by CD4+ T cells promotes the development of gastric cancer. (23378345)
2013
4
Helicobacter pylori and gastritis: the role of extracellular matrix metalloproteases, their inhibitors, and the disintegrins and metalloproteases--a systematic literature review. (23817928)
2013
5
Imbalanced network biomarkers for traditional Chinese medicine Syndrome in gastritis patients. (23529020)
2013
6
Prevalence of H. pylori infection and atrophic gastritis among symptomatic and dyspeptic adults in Kazakhstan. A hospital-based screening study using a panel of serum biomarkers. (24123036)
2013
7
Epstein Barr virus and Helicobacter pylori co-infection are positively associated with severe gastritis in pediatric patients. (23638154)
2013
8
Helicobacter pylori infection has no impact on manometric and pH-metric findings in adolescents and young adults with gastroesophageal reflux and antral gastritis: eradication results to no significant clinical improvement. (23667732)
2013
9
Extended gastritis cystica profunda associated with Epstein-Barr virus-positive dysplasia and carcinoma with lymphoid stroma. (22524666)
2012
10
Duodenal gastrinoma with multiple gastric neuroendocrine tumors secondary to chronic Helicobacter pylori gastritis. (22588069)
2012
11
Severe CMV reactivation and gastritis during treatment of follicular lymphoma with bendamustine. (21811782)
2012
12
Prevalence of Helicobacter pylori infection and atrophic gastritis in Latvia. (23114744)
2012
13
The number of Helicobacter pylori CagA EPIYA C tyrosine phosphorylation motifs influences the pattern of gastritis and the development of gastric carcinoma. (22348604)
2012
14
Frequency of Helicobacter pylori in biopsy proven gastritis and its association with lymphoid follicle formation. (21375161)
2011
15
Manifestation of spontaneous and early autoimmune gastritis in CCR7-deficient mice. (21801869)
2011
16
Case of secondary syphilis presenting with unusual complications: syphilitic proctitis, gastritis, and hepatitis. (21998411)
2011
17
Gastritis: beyond Helicobacter pylori. (20484257)
2010
18
Nuclear factor kappa-B and histopathology of chronic gastritis. (20699495)
2010
19
Association of the human leukocyte antigen class II alleles with chronic atrophic gastritis and gastric carcinoma in Koreans. (19906105)
2009
20
Hemorrhagic gastritis and duodenitis following celiac plexus neurolysis. (19935986)
2009
21
Rapid regression of multiple gastric carcinoid tumors with hypergastrinemia and atrophic gastritis after renal transplantation. (17763955)
2008
22
Severity of atrophic gastritis related to antiparietal cell antibody and gastric carcinogenesis, including p53 mutations. (16638096)
2006
23
Local expressions of TGF-beta1, TGF-beta1RI, CTGF, and Smad-7 in Helicobacter pylori-associated gastritis. (16938712)
2006
24
Altered expression of Skp2, c-Myc and p27 proteins but not mRNA after H. pylori eradication in chronic gastritis. (16118628)
2006
25
Expression of cytokeratins in Helicobacter pylori-associated chronic gastritis of adult patients infected with cagA+ strains: an immunohistochemical study. (16609992)
2006
26
Comparison of prevalence of chronic atrophic gastritis in Japan, China, Tanzania, and the Dominican Republic. (16118004)
2005
27
Study on the pathophysiologic basis of classification of 'spleen' deficiency in chronic gastritis. (15788127)
2005
28
Invasive and non-invasive diagnosis of Helicobacter pylori-associated atrophic gastritis: a comparative study. (15932170)
2005
29
Mechanism of action of low recurrence of gastritis caused by Helicobacter pylori with the type II urease B gene. (15068420)
2004
30
Serum pepsinogens as a predicator of the topography of intestinal metaplasia in patients with atrophic gastritis. (15259501)
2004
31
Collagenous gastritis: a long-term follow-up with the development of endocrine cell hyperplasia, intestinal metaplasia, and epithelial changes indeterminate for dysplasia. (11710694)
2001
32
Double gastric infection with Helicobacter pylori and non-Helicobacter pylori bacteria during acid-suppressive therapy: increase of pro-inflammatory cytokines and development of atrophic gastritis. (11472319)
2001
33
Expression of bcl-2 in autoimmune and Helicobacter pylori-associated atrophic gastritis. (10219822)
1999
34
Primary gastric plasmacytoma: a rare cause of hypertrophic gastritis in an adolescent. (10512402)
1999
35
Granulomatous gastritis presenting as gastric outlet obstruction: a case report. (9789139)
1998
36
Lymphocytic gastritis and coeliac disease: evidence of a positive association. (9659261)
1998
37
Positive result by serology indicates active Helicobacter pylori infection in patients with atrophic gastritis. (9620430)
1998
38
Helicobacter pylori and the risk and management of associated diseases: gastritis, ulcer disease, atrophic gastritis and gastric cancer. (9146793)
1997
39
Cytokine gene expression in the gastric mucosa: its role in chronic gastritis. (8844467)
1996
40
Presence of the cagA gene in the majority of Helicobacter pylori strains is independent of whether the individual has duodenal ulcer or asymptomatic gastritis. (9398887)
1996
41
A study of accessory cells in the acquired lymphoid tissue of helicobacter gastritis. (8943810)
1996
42
Comparative observations on the types of atrophic gastritis and biopsy pathology of gastric mucosa. (7877344)
1994
43
Composite gastric carcinoma and precursor lesions with amphicrine features in chronic atrophic gastritis. (8381247)
1993
44
Xanthogranulomatous gastritis: association with xanthogranulomatous cholecystitis. (8432899)
1993
45
Campylobacter pylori and duodenogastric reflux in peptic ulcer disease and gastritis. (2891956)
1988
46
Gastric carcinoids and atrophic gastritis. Evidence for an association. (6847375)
1983
47
Chronic erosive gastritis. (7161586)
1982
48
Bile reflux gastritis and esophagitis in patients without prior gastric surgery, with pilot study of the therapeutic effects of metoclopramide. (7337127)
1981
49
Gastric acid secretion in chronic atrophic gastritis and chronic (superficial) gastritis. (887004)
1977
50
Gastritis, duodenitis, and bleeding duodenal ulcer following mefenamic acid therapy. (949194)
1976

Variations for Gastritis

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Expression for genes affiliated with Gastritis

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Search GEO for disease gene expression data for Gastritis.

Pathways for genes affiliated with Gastritis

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Pathways related to Gastritis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7NOS2, IL8
2
Show member pathways
9.5CAT, SOD1
3
Show member pathways
Vitamin B12 Metabolism36
9.5CAT, SOD1
49.5CAT, SOD1
5
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
9.4IL1RN, IL8, NOS2
6
Show member pathways
9.1NOS2, CAT, SOD1
79.1NOS2, CAT, SOD1
8
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
9.1DEFB4A, IL8, NOS2

Compounds for genes affiliated with Gastritis

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Compounds related to Gastritis according to GeneCards Suite gene sharing:

(show top 50)    (show all 213)
idCompoundScoreTop Affiliating Genes
1diphenyliodonium439.4CAT, SOD1, NOS2
2ptio439.4CAT, NOS2, SOD1
3pepsinogen439.3SCT, CHGA, GAST, PGC
4oxyntomodulin43 5910.3SCT, CHGA, GAST, GHRL
5ranitidine43 28 24 1212.2GAST, CHGA, ADH7, SCT
6alpha lipoic acid439.2CAT, NOS2, SOD1, GHRL
7gsno439.1NOS2, CAT, ODC1, SOD1
8mannitol43 1210.1SOD1, GHRL, CAT, SCT, ODC1
9s-nitroso-n-acetylpenicillamine439.1IL8, CAT, NOS2, SOD1
10octreotide43 59 28 1212.0CHGA, GAST, GHRL, SCT
11l-nmma439.0GHRL, IL1RN, CAT, NOS2, SOD1
12diphenyleneiodonium439.0NOS2, CAT, SOD1, IL8
13c-peptide438.9CHGA, SCT, GHRL, GAST
14clarithromycin43 129.9S100A8, IL8, GAST, IL1RN
15ng-nitro-l-arginine438.9GAST, NOS2, SOD1, ODC1
16bromodeoxyuridine438.8IL1RN, TFF1, ODC1, CHGA, GAST
17egcg438.8SOD1, NOS2, IL8, ODC1, CAT
18acth438.8SCT, GAST, GHRL, IL1RN, CHGA
19isoproterenol43 129.7GAST, NOS2, SCT, ODC1, CHGA
20omeprazole43 49 28 24 1212.7GAST, S100A8, CHGA, SCT, ADH7
21indomethacin43 28 59 1211.6NOS2, TFF1, SCT, SOD1, IL1RN, CAT
22resveratrol43 59 24 1211.5TFF1, NOS2, GAST, ODC1, SOD1
23lactate438.5CAT, GHRL, IL8, IL1RN, SOD1, ODC1
24endotoxin438.4NOS2, GHRL, S100A8, DEFB4A, IL1RN, IL8
25arginine438.4GHRL, NOS2, TFF1, ODC1, SCT, CHGA
26cycloheximide438.4IL8, ODC1, TFF1, IL1RN, CHGA, CAT
27rantes438.4S100A8, IL8, IL1RN, DEFB4A, SCT
28paraffin438.4DEFB4A, TFF1, ODC1, CHGA, GHRL, S100A8
29thymidine43 249.4SCT, GAST, TFF1, CDX2, ODC1, GHRL
30testosterone43 59 24 1211.3IL1RN, CHGA, GAST, GHRL, TFF1, ODC1
31adenylate438.3IL1RN, NOS2, GAST, GHRL, CHGA, SCT
32zinc43 249.3CHGA, ADH7, S100A8, GHRL, SOD1, IL1RN
33pge2438.2GAST, IL8, NOS2, IL1RN, ODC1, SCT
34h2o2438.2ODC1, NOS2, IL8, IL1RN, SOD1, CAT
35ascorbic acid43 249.1CAT, SOD1, IL1RN, NOS2, GAST, ODC1
36superoxide43 249.0SOD1, IL8, NOS2, IL1RN, CAT, S100A8
37vegf438.0NOS2, TFF1, CHGA, IL1RN, GHRL, GAST
38retinoic acid43 248.9S100A8, ADH7, IL1RN, DEFB4A, TFF1, SCT
39polyacrylamide437.9GAST, S100A8, IL1RN, TFF1, CHGA
40oxygen43 248.8GHRL, SOD1, IL1RN, IL8, CAT, S100A8
41creatinine437.7GAST, S100A8, IL1RN, CHGA, SOD1, GHRL
42sb 20358043 598.6DEFB4A, CAT, IL8, IL1RN, ODC1, NOS2
43lipid437.6S100A8, CAT, GHRL, IL1RN, CHGA, SOD1
44nitric oxide43 24 129.6SOD1, CAT, GHRL, IL8, IL1RN, NOS2
45estrogen437.4IL1RN, DEFB4A, ODC1, TFF1, CHGA, GAST
46glutamate437.3CHGA, IL1RN, S100A8, GAST, NOS2, SOD1
47tyrosine437.3S100A8, CDX2, GAST, GHRL, IL1RN, DEFB4A
48histamine43 28 249.3ODC1, GHRL, S100A8, DEFB4A, SCT, GAST
49dexamethasone43 49 28 1210.0TFF1, CHGA, IL1RN, IL8, S100A8, GAST
50cysteine436.7SOD1, CHGA, IL1RN, IL8, CAT, S100A8

GO Terms for genes affiliated with Gastritis

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Cellular components related to Gastritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peroxisomeGO:00057779.1NOS2, CAT, SOD1
2extracellular spaceGO:00056157.7TFF1, SOD1, PGC, IL1RN, IL8, GHRL
3extracellular regionGO:00055766.4GAST, DEFB4A, SCT, SOD1, ADH7, CHGA

Biological processes related to Gastritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1response to bacteriumGO:00096179.7NOS2, ADH7
2superoxide metabolic processGO:00068019.2NOS2, SOD1
3response to ethanolGO:00454719.1S100A8, ADH7, SOD1
4defense response to bacteriumGO:00427428.8DEFB4A, S100A8, NOS2
5G-protein coupled receptor signaling pathwayGO:00071868.5GAST, GHRL, IL8, DEFB4A

Products for genes affiliated with Gastritis

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Sources for Gastritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet