MCID: GST044
MIFTS: 66

Gastritis malady

Gastrointestinal diseases category
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Summaries for Gastritis

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Wikipedia:65 Gastritis is inflammation of the lining of the stomach and has many possible causes. Common causes of... more...

MalaCards based summary: Gastritis, also known as acute gastritis without mention of hemorrhage, is related to duodenitis and pernicious anemia. An important gene associated with Gastritis is PGC (progastricsin (pepsinogen C)), and among its related pathways are Immune response MIF mediated glucocorticoid regulation and Folate Metabolism. The drugs sucralfate and cat's claw preparation and the compounds diphenyliodonium and ptio have been mentioned in the context of this disorder. Affiliated tissues include testes, t cells and colon, and related mouse phenotypes are digestive/alimentary and tumorigenesis.

Disease Ontology:8 A stomach disease that is an inflammation of the lining of the stomach.

Aliases & Classifications for Gastritis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 39NCIt, 57SNOMED-CT, 34MeSH, 25ICD10
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Gastritis, Aliases & Descriptions:

Name: Gastritis 8 10 44 62
Acute Gastritis Without Mention of Hemorrhage 8 62
Idiopathic Erosive/hemorrhagic Gastritis 8 62
Acute Gastritis with Hemorrhage 8 62
Acute Gastric Mucosal Erosion 8 62
Chronic Gastritis 8 62
Acute Gastritis 8 62
Acute Gastritis, Without Mention of Hemorrhage 8
Acute Gastritis, with Hemorrhage 8
 
Acute Haemorrhagic Gastritis 8
Gastritis Hemorrhagic 8
Hemorrhagic Gastritis 8
Gastritis Unspecified 8
Chronic Gastritis Nos 8
Erosive Gastropathy 8
Erosive Gastritis 8
Gastritis Chronic 44
Gastritis Erosive 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology8 DOID:4029
NCIt39 C26780
MeSH34 D005756
ICD1025 K29.0, K29.7

Related Diseases for Gastritis

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Diseases in the Gastritis family:

Bacterial Gastritis Viral Gastritis

Diseases related to Gastritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 281)
idRelated DiseaseScoreTop Affiliating Genes
1duodenitis31.8S100A8, GAST
2pernicious anemia31.6GAST
3duodenogastric reflux31.5GAST
4duodenal ulcer31.2SCT, IL1RN, S100A8, GAST
5dyspepsia31.1GAST, GHRL
6gastric ulcer31.0GAST, S100A8, GHRL, ODC1, TFF1
7stomach cancer31.0PGC, GAST, CDX2
8esophagitis30.9CAT, S100A8, GAST, CDX2
9zollinger-ellison syndrome30.9SCT, CHGA, GAST
10peptic ulcer disease30.9SCT, PGC, IL8, S100A8, GAST
11neuroendocrine tumor30.8CHGA
12collagenous colitis30.7NOS2
13gastrinoma30.6SCT, CHGA, GAST
14neuroendocrine carcinoma30.5CDX2, GAST, CHGA
15wermer syndrome30.4CHGA, GAST
16atrophic gastritis30.4TFF1, SCT, ODC1, SOD1, ADH7, CHGA
17gastroesophageal reflux disease30.3SCT, S100A8, GAST
18tubular adenocarcinoma30.3CHGA, CDX2
19primary hyperparathyroidism30.2SCT, CHGA, GAST
20hyperparathyroidism30.2SCT, CHGA, GAST
21colitis30.2DEFB4A, TFF1, IL1RN, IL8, NOS2
22barrett's esophagus30.1TFF1, ODC1, S100A8, GAST, CDX2
23cholera30.0ODC1, SCT, TFF1
24colorectal cancer30.0TFF1, ODC1, GHRL, S100A8, GAST, CDX2
25pancreatic cancer30.0CDX2, GAST, SCT, TFF1
26adenocarcinoma30.0TFF1, SCT, ODC1, CHGA, GHRL, S100A8
27rheumatoid arthritis30.0IL1RN, IL8, GHRL, S100A8, NOS2
28arthritis30.0IL1RN, IL8, GHRL, S100A8, NOS2
29type 1 diabetes mellitus29.9IL1RN, NOS2
30carcinoid syndrome29.9SCT, CHGA, GHRL, GAST, CDX2
31gastric adenocarcinoma29.9CDX2, GAST, S100A8, IL1RN, DEFB4A, TFF1
32septic shock29.9NOS2, IL8, IL1RN
33adenoma29.8TFF1, SCT, ODC1, CHGA, GHRL, S100A8
34ulcerative colitis29.7DEFB4A, TFF1, IL1RN, IL8, NOS2
35diabetes mellitus29.7SCT, SOD1, GHRL, CAT
36acute pancreatitis29.6IL8, IL1RN, SOD1, SCT
37inflammatory bowel disease29.5DEFB4A, TFF1, SCT, IL1RN, IL8, S100A8
38type 2 diabetes mellitus29.5SCT, SOD1, GHRL, CAT
39atherosclerosis29.0SOD1, IL1RN, IL8, GHRL, CAT, NOS2
40gastric cancer10.9
41lymphocytic gastritis10.8
42granulomatous gastritis10.7
43eosinophilic gastritis10.6
44bile reflux10.6
45collagenous gastritis10.6
46chronic erosive gastritis10.5
47sleeping sickness10.5ODC1
48autoimmune atrophic gastritis10.5
49necrotizing gastritis10.5
50acinar cell carcinoma10.4CHGA, GAST

Graphical network of the top 20 diseases related to Gastritis:



Diseases related to gastritis

Symptoms for Gastritis

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Drugs & Therapeutics for Gastritis

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Drug clinical trials:

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Search NIH Clinical Center for Gastritis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Gastritis

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Anatomical Context for Gastritis

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MalaCards organs/tissues related to Gastritis:

32
Testes, T cells, Colon, Thyroid, Endothelial, Spleen, B cells, Heart, Liver, Myeloid, Tongue, Neutrophil, Bone, Lymph node, Thymus, Pancreas, Pituitary

Animal Models for Gastritis or affiliated genes

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MGI Mouse Phenotypes related to Gastritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.4CDX2, NOS2, GAST, GHRL, TFF1
2MP:00020067.9TFF1, CAT, GAST, NOS2, CDX2
3MP:00053797.5TFF1, SOD1, CHGA, GHRL, GAST, NOS2
4MP:00053766.4CDX2, TFF1, SCT, SOD1, ADH7, CHGA
5MP:00107686.3CHGA, ADH7, SOD1, ODC1, IL1RN, CAT

Publications for Gastritis

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Articles related to Gastritis:

(show top 50)    (show all 1540)
idTitleAuthorsYear
1
Long-term treatment of patients with a history of ulcerative colitis who develop gastritis and pan-enteritis after colectomy. (22858512)
2013
2
Phlegmonous gastritis after esophagectomy: a case report. (23482416)
2013
3
Autoimmune gastritis mediated by CD4+ T cells promotes the development of gastric cancer. (23378345)
2013
4
Helicobacter pylori and gastritis: the role of extracellular matrix metalloproteases, their inhibitors, and the disintegrins and metalloproteases--a systematic literature review. (23817928)
2013
5
Imbalanced network biomarkers for traditional Chinese medicine Syndrome in gastritis patients. (23529020)
2013
6
Prevalence of H. pylori infection and atrophic gastritis among symptomatic and dyspeptic adults in Kazakhstan. A hospital-based screening study using a panel of serum biomarkers. (24123036)
2013
7
Epstein Barr virus and Helicobacter pylori co-infection are positively associated with severe gastritis in pediatric patients. (23638154)
2013
8
Helicobacter pylori infection has no impact on manometric and pH-metric findings in adolescents and young adults with gastroesophageal reflux and antral gastritis: eradication results to no significant clinical improvement. (23667732)
2013
9
Extended gastritis cystica profunda associated with Epstein-Barr virus-positive dysplasia and carcinoma with lymphoid stroma. (22524666)
2012
10
Duodenal gastrinoma with multiple gastric neuroendocrine tumors secondary to chronic Helicobacter pylori gastritis. (22588069)
2012
11
Severe CMV reactivation and gastritis during treatment of follicular lymphoma with bendamustine. (21811782)
2012
12
Prevalence of Helicobacter pylori infection and atrophic gastritis in Latvia. (23114744)
2012
13
Frequency of Helicobacter pylori in biopsy proven gastritis and its association with lymphoid follicle formation. (21375161)
2011
14
Manifestation of spontaneous and early autoimmune gastritis in CCR7-deficient mice. (21801869)
2011
15
Case of secondary syphilis presenting with unusual complications: syphilitic proctitis, gastritis, and hepatitis. (21998411)
2011
16
Myotonic dystrophy type 2 and autoimmune chronic gastritis: an incidental association? (21948056)
2011
17
Gastritis: beyond Helicobacter pylori. (20484257)
2010
18
Nuclear factor kappa-B and histopathology of chronic gastritis. (20699495)
2010
19
Association of the human leukocyte antigen class II alleles with chronic atrophic gastritis and gastric carcinoma in Koreans. (19906105)
2009
20
Hemorrhagic gastritis and duodenitis following celiac plexus neurolysis. (19935986)
2009
21
Rapid regression of multiple gastric carcinoid tumors with hypergastrinemia and atrophic gastritis after renal transplantation. (17763955)
2008
22
Severity of atrophic gastritis related to antiparietal cell antibody and gastric carcinogenesis, including p53 mutations. (16638096)
2006
23
Local expressions of TGF-beta1, TGF-beta1RI, CTGF, and Smad-7 in Helicobacter pylori-associated gastritis. (16938712)
2006
24
Altered expression of Skp2, c-Myc and p27 proteins but not mRNA after H. pylori eradication in chronic gastritis. (16118628)
2006
25
Expression of cytokeratins in Helicobacter pylori-associated chronic gastritis of adult patients infected with cagA+ strains: an immunohistochemical study. (16609992)
2006
26
Comparison of prevalence of chronic atrophic gastritis in Japan, China, Tanzania, and the Dominican Republic. (16118004)
2005
27
Study on the pathophysiologic basis of classification of 'spleen' deficiency in chronic gastritis. (15788127)
2005
28
Symptomatic eosinophilic gastritis cured with Helicobacter pylori eradication. (16284301)
2005
29
Invasive and non-invasive diagnosis of Helicobacter pylori-associated atrophic gastritis: a comparative study. (15932170)
2005
30
Mechanism of action of low recurrence of gastritis caused by Helicobacter pylori with the type II urease B gene. (15068420)
2004
31
Serum pepsinogens as a predicator of the topography of intestinal metaplasia in patients with atrophic gastritis. (15259501)
2004
32
Collagenous gastritis: a long-term follow-up with the development of endocrine cell hyperplasia, intestinal metaplasia, and epithelial changes indeterminate for dysplasia. (11710694)
2001
33
Double gastric infection with Helicobacter pylori and non-Helicobacter pylori bacteria during acid-suppressive therapy: increase of pro-inflammatory cytokines and development of atrophic gastritis. (11472319)
2001
34
Expression of bcl-2 in autoimmune and Helicobacter pylori-associated atrophic gastritis. (10219822)
1999
35
Primary gastric plasmacytoma: a rare cause of hypertrophic gastritis in an adolescent. (10512402)
1999
36
Granulomatous gastritis presenting as gastric outlet obstruction: a case report. (9789139)
1998
37
Lymphocytic gastritis and coeliac disease: evidence of a positive association. (9659261)
1998
38
Positive result by serology indicates active Helicobacter pylori infection in patients with atrophic gastritis. (9620430)
1998
39
Helicobacter pylori and the risk and management of associated diseases: gastritis, ulcer disease, atrophic gastritis and gastric cancer. (9146793)
1997
40
Cytokine gene expression in the gastric mucosa: its role in chronic gastritis. (8844467)
1996
41
Presence of the cagA gene in the majority of Helicobacter pylori strains is independent of whether the individual has duodenal ulcer or asymptomatic gastritis. (9398887)
1996
42
A study of accessory cells in the acquired lymphoid tissue of helicobacter gastritis. (8943810)
1996
43
Comparative observations on the types of atrophic gastritis and biopsy pathology of gastric mucosa. (7877344)
1994
44
Composite gastric carcinoma and precursor lesions with amphicrine features in chronic atrophic gastritis. (8381247)
1993
45
Xanthogranulomatous gastritis: association with xanthogranulomatous cholecystitis. (8432899)
1993
46
Campylobacter pylori and duodenogastric reflux in peptic ulcer disease and gastritis. (2891956)
1988
47
Gastric carcinoids and atrophic gastritis. Evidence for an association. (6847375)
1983
48
Chronic erosive gastritis. (7161586)
1982
49
Gastric acid secretion in chronic atrophic gastritis and chronic (superficial) gastritis. (887004)
1977
50
Gastritis, duodenitis, and bleeding duodenal ulcer following mefenamic acid therapy. (949194)
1976

Variations for Gastritis

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Expression for genes affiliated with Gastritis

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Expression patterns in normal tissues for genes affiliated with Gastritis

Search GEO for disease gene expression data for Gastritis.

Pathways for genes affiliated with Gastritis

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Pathways related to Gastritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7NOS2, IL8
2
Show member pathways
Vitamin B12 Metabolism37
9.5CAT, SOD1
39.5SOD1, CAT
4
Show member pathways
9.5CAT, SOD1
5
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.4NOS2, IL1RN, IL8
6
Show member pathways
9.1NOS2, SOD1, CAT
79.1NOS2, SOD1, CAT
8
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.1DEFB4A, IL8, NOS2

Compounds for genes affiliated with Gastritis

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Compounds related to Gastritis according to GeneCards/GeneDecks:

(show top 50)    (show all 213)
idCompoundScoreTop Affiliating Genes
1diphenyliodonium449.4CAT, SOD1, NOS2
2ptio449.4CAT, NOS2, SOD1
3pepsinogen449.3SCT, CHGA, GAST, PGC
4oxyntomodulin44 6110.3SCT, CHGA, GAST, GHRL
5ranitidine44 28 24 1112.2GAST, CHGA, ADH7, SCT
6alpha lipoic acid449.2CAT, NOS2, SOD1, GHRL
7gsno449.1NOS2, CAT, ODC1, SOD1
8mannitol44 1110.1SOD1, GHRL, CAT, SCT, ODC1
9s-nitroso-n-acetylpenicillamine449.1IL8, CAT, NOS2, SOD1
10octreotide44 61 28 1112.0CHGA, GAST, GHRL, SCT
11l-nmma449.0GHRL, IL1RN, CAT, NOS2, SOD1
12diphenyleneiodonium449.0NOS2, CAT, SOD1, IL8
13c-peptide448.9CHGA, SCT, GHRL, GAST
14clarithromycin44 119.9S100A8, IL8, GAST, IL1RN
15ng-nitro-l-arginine448.9GAST, NOS2, SOD1, ODC1
16bromodeoxyuridine448.8IL1RN, TFF1, ODC1, CHGA, GAST
17egcg448.8SOD1, NOS2, IL8, ODC1, CAT
18acth448.8SCT, GAST, GHRL, IL1RN, CHGA
19isoproterenol44 119.7GAST, NOS2, SCT, ODC1, CHGA
20omeprazole44 50 28 24 1112.7GAST, S100A8, CHGA, SCT, ADH7
21indomethacin44 28 61 1111.6NOS2, TFF1, SCT, SOD1, IL1RN, CAT
22resveratrol44 61 24 1111.5TFF1, NOS2, GAST, ODC1, SOD1
23lactate448.5CAT, GHRL, IL8, IL1RN, SOD1, ODC1
24endotoxin448.4NOS2, GHRL, S100A8, DEFB4A, IL1RN, IL8
25arginine448.4GHRL, NOS2, TFF1, ODC1, SCT, CHGA
26cycloheximide448.4IL8, ODC1, TFF1, IL1RN, CHGA, CAT
27rantes448.4S100A8, IL8, IL1RN, DEFB4A, SCT
28paraffin448.4DEFB4A, TFF1, ODC1, CHGA, GHRL, S100A8
29thymidine44 249.4SCT, GAST, TFF1, CDX2, ODC1, GHRL
30testosterone44 61 24 1111.3IL1RN, CHGA, GAST, GHRL, TFF1, ODC1
31adenylate448.3IL1RN, NOS2, GAST, GHRL, CHGA, SCT
32zinc44 249.3CHGA, ADH7, S100A8, GHRL, SOD1, IL1RN
33pge2448.2GAST, IL8, NOS2, IL1RN, ODC1, SCT
34h2o2448.2ODC1, NOS2, IL8, IL1RN, SOD1, CAT
35ascorbic acid44 249.1CAT, SOD1, IL1RN, NOS2, GAST, ODC1
36superoxide44 249.0SOD1, IL8, NOS2, IL1RN, CAT, S100A8
37vegf448.0NOS2, TFF1, CHGA, IL1RN, GHRL, GAST
38retinoic acid44 248.9S100A8, ADH7, IL1RN, DEFB4A, TFF1, SCT
39polyacrylamide447.9GAST, S100A8, IL1RN, TFF1, CHGA
40oxygen44 248.8GHRL, SOD1, IL1RN, IL8, CAT, S100A8
41creatinine447.7GAST, S100A8, IL1RN, CHGA, SOD1, GHRL
42sb 20358044 618.6DEFB4A, CAT, IL8, IL1RN, ODC1, NOS2
43lipid447.6S100A8, CAT, GHRL, IL1RN, CHGA, SOD1
44nitric oxide44 24 119.6SOD1, CAT, GHRL, IL8, IL1RN, NOS2
45estrogen447.4IL1RN, DEFB4A, ODC1, TFF1, CHGA, GAST
46glutamate447.3CHGA, IL1RN, S100A8, GAST, NOS2, SOD1
47tyrosine447.3S100A8, CDX2, GAST, GHRL, IL1RN, DEFB4A
48histamine44 28 249.3ODC1, GHRL, S100A8, DEFB4A, SCT, GAST
49dexamethasone44 50 28 1110.0TFF1, CHGA, IL1RN, IL8, S100A8, GAST
50cysteine446.7SOD1, CHGA, IL1RN, IL8, CAT, S100A8

GO Terms for genes affiliated with Gastritis

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Cellular components related to Gastritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peroxisomeGO:0057779.1NOS2, CAT, SOD1
2extracellular spaceGO:0056157.7TFF1, SOD1, PGC, IL1RN, IL8, GHRL
3extracellular regionGO:0055766.4GAST, DEFB4A, SCT, SOD1, ADH7, CHGA

Biological processes related to Gastritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to bacteriumGO:0096179.7NOS2, ADH7
2superoxide metabolic processGO:0068019.2NOS2, SOD1
3response to ethanolGO:0454719.1S100A8, ADH7, SOD1
4defense response to bacteriumGO:0427428.8DEFB4A, S100A8, NOS2
5G-protein coupled receptor signaling pathwayGO:0071868.5GAST, GHRL, IL8, DEFB4A

Products for genes affiliated with Gastritis

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Sources for Gastritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet