MCID: GST044
MIFTS: 68

Gastritis malady

Gastrointestinal diseases category

Summaries for Gastritis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Gastritis is inflammation of the lining of the stomach and has many possible causes. Common causes of... more...

MalaCards: Gastritis, also known as idiopathic erosive/hemorrhagic gastritis, is related to atrophic gastritis and duodenitis. An important gene associated with Gastritis is PGC (progastricsin (pepsinogen C)), and among its related pathways are Immune response Bacterial infections in normal airways and Doxorubicin Pathway, Pharmacokinetics. The drugs sucralfate and cat's claw preparation and the compounds cysteine and histamine have been mentioned in the context of this disorder. Affiliated tissues include testes, t cells and colon, and related mouse phenotypes are homeostasis/metabolism and immune system.

Disease Ontology:8 A stomach disease that is an inflammation of the lining of the stomach.

Aliases & Classifications for Gastritis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

gastritis 8 10 44 60
idiopathic erosive/hemorrhagic gastritis 8 60
acute gastric mucosal erosion 8 60
other specified gastritis 8 60
chronic gastritis 8 60
acute gastritis 8 60
other specified gastritis, without mention of hemorrhage 8
acute gastritis, without mention of hemorrhage 8
acute gastritis without mention of hemorrhage 8
other specified gastritis, with hemorrhage 8
acute gastritis, with hemorrhage 8
acute gastritis with hemorrhage 8
other specified gastritis nos 8
acute haemorrhagic gastritis 8
acute hemorrhagic gastritis 8
chronic gastritis nos 8
gastritis hemorrhagic 8
gastritis unspecified 8
hemorrhagic gastritis 8
erosive gastropathy 8
erosive gastritis 8
gastritis chronic 44
gastritis erosive 44


External Ids:

Disease Ontology8 DOID:4029
NCIt39 C26780
MeSH34 D005756
ICD1025 K29.0, K29.7

Related Diseases for Gastritis

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17GeneCards, 18GeneDecks
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Diseases in the Gastritis family:

Bacterial Gastritis Viral Gastritis

Diseases related to Gastritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 310)
idRelated DiseaseScoreTop Affiliating Genes
1atrophic gastritis31.7IL1RN, CDX2, CHGA, GHRL, AKR1A1, TFF2
2duodenitis31.1S100A8, GAST
3gastric ulcer31.0GHRL, TFF2, TFF1, GAST, S100A8, ODC1
4peptic ulcer30.9IL8, PGC, AKR1A1, GAST, SCT, S100A8
5duodenal ulcer30.9S100A8, SCT, GAST, IL1RN
6bile reflux30.8TFF1
7adenocarcinoma30.7NOS2, CDX2, CHGA, GHRL, AREG, TFF2
8esophagitis30.7CAT, S100A8, GAST, CDX2
9gastric adenocarcinoma30.6ODC1, S100A8, GAST, TFF1, DEFB4A, CHGA
10duodenogastric reflux30.5GAST
11stomach cancer30.5GAST, CDX2, PGC
12celiac disease30.4GHRL
13dyspepsia30.4GHRL, GAST
14deficiency anemia30.4GHRL, AREG
15pancreatitis30.3SCT, SOD1
16zollinger-ellison syndrome30.2SCT, GAST, CHGA
17inflammatory bowel disease30.2S100A8, SCT, TFF1, TFF2, AREG, DEFB4A
18hepatitis30.2AKR1A1, CAT
19gastroduodenitis30.2GAST
20adenoma30.1CDX2, CHGA, GHRL, AREG, TFF1, GAST
21colorectal cancer30.0ODC1, S100A8, GAST, TFF1, AREG, CDX2
22rheumatoid arthritis30.0S100A8, AREG, GHRL, IL1RN, IL8, NOS2
23arthritis30.0NOS2, IL8, IL1RN, GHRL, S100A8
24ulcerative colitis30.0TFF1, DEFB4A, IL1RN, IL8, NOS2
25sarcoidosis30.0IL1RN, DEFB4A
26gastrinoma30.0SCT, GAST, CHGA
27squamous cell carcinoma29.9ODC1, S100A8, TFF1, AREG, AKR1A1, DEFB4A
28atherosclerosis29.9CAT, SOD1, GHRL, IL1RN, IL8, NOS2
29diabetes mellitus29.9CAT, SOD1, SCT, GHRL
30neuroendocrine carcinoma29.9GAST, CHGA, CDX2
31vitiligo29.9SOD1, CAT
32obesity29.9GHRL
33neuroendocrine tumor29.9CHGA
34hepatocellular carcinoma29.7S100A8, SCT, AREG, AKR1A1, GHRL, CDX2
35leukemia29.7ODC1, CAT, S100A8, CTSW, AREG, CDX2
36acute pancreatitis29.7SOD1, SCT, IL1RN, IL8
37wermer syndrome29.7SCT, GAST, GHRL, CHGA
38pancreatic cancer29.7SCT, GAST, CHGA, CDX2
39gastroesophageal reflux disease29.7S100A8, SCT, GAST
40primary hyperparathyroidism29.7CHGA, GAST, SCT
41pituitary adenoma29.7CHGA, GHRL
42myocardial infarction29.7GHRL, AKR1A1
43type 2 diabetes mellitus29.7GHRL, SCT, SOD1, CAT
44cholera29.7TFF1, SCT, ODC1
45hyperhomocysteinemia29.7SOD1
46malt lymphoma29.7S100A8
47sarcoma29.7ODC1
48hyperparathyroidism29.7SCT, GAST, CHGA
49lymphocytic gastritis10.7
50granulomatous gastritis10.6

Graphical network of the top 20 diseases related to Gastritis:



Diseases related to gastritis

Clinical Features for Gastritis

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Drugs & Therapeutics for Gastritis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Gastritis

Drug clinical trials:

Search ClinicalTrials for Gastritis

Search NIH Clinical Center for Gastritis

Search CenterWatch for Gastritis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Gastritis

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Anatomical Context for Gastritis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Gastritis:

32
Testes, T cells, Colon, Endothelial, Thyroid, B cells, Spleen, Liver, Tongue, Myeloid, Heart, Lymph node, Thymus, Pituitary, Bone, Pancreas

Animal Models for Gastritis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Gastritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537611.3ADH7, SOD1, SCT, GAST, TFF2, AKR1A1
2MP:000538711.2CTSW, GAST, TFF2, AREG, AKR1A1, IL1RN
3MP:001076811.1ODC1, CAT, S100A8, SOD1, GAST, AKR1A1
4MP:000538110.9GAST, TFF1, TFF2, AREG, GHRL, CDX2
5MP:000537910.8GAST, TFF2, AREG, CDX2

Publications for Gastritis

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Sources:
50PubMed
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Articles related to Gastritis:

(show top 50)    (show all 1507)
idTitleAuthorsYear
1
Metabolic markers and microecological characteristics of tongue coating in patients with chronic gastritis. (24041039)
2013
2
vacA genotypes of Helicobacter pylori in the oral cavity and stomach of patients with chronic gastritis and gastric ulcer. (23084752)
2013
3
Discretized data pattern in endoscopic gastritis images using dynamic window and pairwise gini criterion. (24111130)
2013
4
Characteristics of the pulse wave in patients with chronic gastritis and the healthy in Korean medicine. (23366061)
2012
5
Hypovitaminosis D as predisposing factor for atrophic type A gastritis: a case-control study and review of the literature on the interaction of Vitamin D with the immune system. (21286859)
2012
6
Ischemic gastritis: a rare but lethal consequence of celiac territory ischemic syndrome. (23232480)
2012
7
Lack of commensal flora in Helicobacter pylori-infected INS-GAS mice reduces gastritis and delays intraepithelial neoplasia. (20950613)
2011
8
The staging of gastritis with the OLGA system by using intestinal metaplasia as an accurate alternative for atrophic gastritis. (20381801)
2010
9
A Case of Intranasal Hemangioma and Concurrent Tetracycline-induced Ulcerative Gastritis in Dogs. (21042472)
2010
10
Cytomegalovirus gastritis. (21173917)
2010
11
Gastritis associated with Epstein-Barr virus infection. (20930436)
2010
12
Proteomic analysis reveals molecular biological details in varioliform gastritis without Helicobacter pylori infection. (20677338)
2010
13
Role of transforming growth factor beta1 in the development of atrophic gastritis]. (20019772)
2009
14
Molecular characterisation and expression analysis of SEREX-defined antigen NUCB2 in gastric epithelium, gastritis and gastric cancer. (19351608)
2009
15
Regulatory T cells in type 1 diabetic patients with autoimmune chronic atrophic gastritis. (19291424)
2009
16
Phlegmonous gastritis in a patient with myeloid sarcoma: a case report. (19644358)
2009
17
Is interleukin-1 genotyping useful for the clinical management of patients with atrophic body gastritis? (18047563)
2008
18
Atrophic gastritis, but not antibody to Helicobacter pylori, is associated with body mass index in a Japanese population. (18958544)
2008
19
Interleukin-10 (-819 C/T) and tumor necrosis factor-alpha (-308 G/A) gene variants influence gastritis and lymphoid follicle development. (17717744)
2008
20
Screening of atrophic gastritis and gastric cancer by serum pepsinogen, gastrin-17 and Helicobacter pylori immunoglobulin G antibodies. (17261130)
2007
21
Altered expression of Skp2, c-Myc and p27 proteins but not mRNA after H. pylori eradication in chronic gastritis. (16118628)
2006
22
Thyroxine in goiter, H. pylori infection, and gastritis. (16971728)
2006
23
Invasive and non-invasive diagnosis of Helicobacter pylori-associated atrophic gastritis: a comparative study. (15932170)
2005
24
Atrophic gastritis in young children and adolescents. (16254110)
2005
25
Interleukin-6 polymorphism and Helicobacter pylori infection in Brazilian adult patients with chronic gastritis. (16284733)
2005
26
Immunohistochemical evaluation of p53 expression and proliferative activity in children with Helicobacter pylori associated gastritis. (15795596)
2005
27
Essential role of MD-2 in TLR4-dependent signaling during Helicobacter pylori-associated gastritis. (15240737)
2004
28
Prof. Shan Zhaowei's experience in treating chronic atrophic gastritis. (15688688)
2004
29
Simultaneous EBV-positive lymphoepithelioma-like carcinoma and EBV-negative intestinal-type adenocarcinoma in a patient with Helicobacter pylori-associated chronic gastritis. (14983938)
2004
30
Epithelial cell proliferation and glandular atrophy in lymphocytic gastritis: effect of H pylori treatment. (14669318)
2003
31
In through the out door: serology for atrophic gastritis. (12867797)
2003
32
High incidence of B-cell monoclonality in follicular gastritis: a possible association between follicular gastritis and MALT lymphoma. (11956817)
2002
33
Increased risk of developing atrophic gastritis in patients infected with CagA+ Helicobacter pylori. (11521982)
2001
34
Micronutrient antioxidants in gastric mucosa and serum in patients with gastritis and gastric ulcer: does Helicobacter pylori infection affect the mucosal levels? (10875465)
2000
35
Hyperplasia of gastric antral beta-microseminoprotein endocrine-like cells and increased serum levels of beta-microseminoprotein in atrophic corpus gastritis. (9759944)
1998
36
Chronic atrophic gastritis: early diagnosis in a population where Helicobacter pylori infection is frequent. (9402346)
1997
37
Role of Helicobacter pylori in the pathogenesis of atrophic gastritis. (9200303)
1997
38
Increased production of interleukin 1 beta and hepatocyte growth factor may contribute to foveolar hyperplasia in enlarged fold gastritis. (9038658)
1996
39
Lymphocytic gastritis. Clinical and endoscopic presentation and long-term follow-up. (7571985)
1995
40
O6-methylguanine in blood leucocyte DNA: an association with the geographic prevalence of gastric cancer and with low levels of serum pepsinogen A, a marker of severe chronic atrophic gastritis. The EUROGAST Study Group. (7923573)
1994
41
Composite gastric carcinoma and precursor lesions with amphicrine features in chronic atrophic gastritis. (8381247)
1993
42
Occurrence of autoantibodies against intrinsic factor, H,K-ATPase, and pepsinogen in atrophic gastritis and rheumatoid arthritis. (1658920)
1991
43
Progress in the pathology of gastritis and duodenitis. (2407435)
1990
44
47 cases of chronic atrophic gastritis treated with the modality of depressing the upward adverse flow of qi. (2630819)
1989
45
An alternative to Roux-en-Y for treatment of bile reflux gastritis. (3336817)
1988
46
Bile reflux gastritis. (3810208)
1987
47
Ursodeoxycholic acid treatment of bile reflux gastritis. (4043659)
1985
48
Magnifying endoscopic observation of the gastric mucosa, particularly in patients with atrophic gastritis. (738222)
1978
49
Bile reflux gastritis. Results of surgical therapy with Roux-en-Y gastrojejunostomy. (4847025)
1974
50
Polypoid eosinophilic gastritis. (5435951)
1970

Genetic Variations for Gastritis

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Expression for genes affiliated with Gastritis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gastritis

Search GEO for disease gene expression data for Gastritis.

Pathways for genes affiliated with Gastritis

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37NCBI BioSystems Database, 49PharmGKB, 29KEGG
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Pathways related to Gastritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Immune response Bacterial infections in normal airways
Hide members
10.8IL1RN, NOS2, IL8, DEFB4A
2
Hide members
10.8CAT, SOD1, AKR1A1, NOS2
310.7CAT, SOD1, NOS2
410.6CAT, SOD1
510.6SOD1, CAT

Compounds for genes affiliated with Gastritis

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44Novoseek, 28IUPHAR, 24HMDB, 11DrugBank, 59Tocris Bioscience, 49PharmGKB
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Compounds related to Gastritis according to GeneCards/GeneDecks:

(show top 50)    (show all 172)
idCompoundScoreTop Affiliating Genes
1cysteine4412.0CAT, IL8, IL1RN, CDX2, CHGA, DEFB4A
2histamine44 28 2413.7ODC1, IL8, IL1RN, CHGA, DEFB4A, SCT
3retinoic acid44 2412.7ODC1, ADH7, SCT, IL1RN, CHGA, AKR1A1
4nitric oxide44 11 2413.6IL8, IL1RN, CHGA, GHRL, NOS2, SOD1
5indomethacin44 59 28 1114.6IL1RN, TFF2, SCT, NOS2, AKR1A1, SOD1
6sb 20358044 5912.6IL8, AREG, NOS2, ODC1, CAT, GAST
7lactate4411.5IL8, IL1RN, CHGA, ODC1, CAT, SOD1
8adenylate4411.5ODC1, AKR1A1, NOS2, SCT, GAST, GHRL
9testosterone44 59 11 2414.5ODC1, IL1RN, TFF1, SCT, GAST, CHGA
10polyacrylamide4411.5GAST, TFF1, AREG, AKR1A1, CHGA, IL1RN
11n acetylcysteine4411.4ODC1, NOS2, CAT, SOD1, AREG, AKR1A1
12vegf4411.4GAST, GHRL, IL8, TFF1, CHGA, AREG
13arginine4411.4TFF1, AKR1A1, CHGA, SCT, SOD1, ODC1
14paraffin4411.4DEFB4A, CHGA, GHRL, TFF1, S100A8, CDX2
15zinc44 2412.4S100A8, SOD1, SCT, IL1RN, AKR1A1, ADH7
16thymidine44 2412.4GHRL, AREG, TFF1, GAST, SCT, ODC1
17isoproterenol44 1112.3SCT, GAST, AREG, ODC1, CHGA, NOS2
18creatinine4411.3S100A8, CHGA, SOD1, IL1RN, AKR1A1, GAST
19dexamethasone44 49 28 1114.3GHRL, S100A8, AREG, DEFB4A, TFF1
20omeprazole44 28 49 11 2415.3CHGA, SCT, S100A8, GAST, ADH7
21oxygen44 2412.3NOS2, IL8, S100A8, CHGA, AKR1A1, GHRL
22gsno4411.3ODC1, SOD1, AKR1A1, CAT, NOS2
23epinephrine44 11 2413.3CHGA, SCT, AREG, GHRL, IL1RN, GAST
24l-nmma4411.3GHRL, NOS2, IL1RN, SOD1, CAT
25lipid4411.3SCT, AKR1A1, GHRL, IL1RN, CHGA, SOD1
26ascorbic acid44 2412.3IL1RN, CAT, SOD1, GAST, NOS2, ODC1
27glutamate4411.2GAST, SCT, GHRL, AKR1A1
28pepsinogen4411.2SCT, GAST, CHGA, PGC
294-hydroxynonenal44 2412.2CAT, SOD1, AKR1A1, NOS2, ODC1
30tyrosine4411.2GAST, SCT, S100A8, AREG, GHRL, DEFB4A
31oxyntomodulin44 5912.2GHRL, SCT, CHGA, GAST
32clarithromycin44 1112.2S100A8, GAST, IL1RN, IL8
33h2o24411.2ODC1, CAT, TFF1, IL1RN
34ng-nitro-l-arginine4411.2GAST, SOD1, ODC1, NOS2
35serine4411.2IL8, IL1RN, GHRL, AKR1A1, SCT, S100A8
36ranitidine44 28 11 2414.2AKR1A1, ADH7, SCT
37mannitol44 1112.1SCT, ODC1, CAT
38endotoxin4411.1S100A8, GHRL, DEFB4A
39calcium44 49 11 2414.1S100A8, IL1RN, CDX2, CHGA, DEFB4A, AREG
40s-nitroso-n-acetylpenicillamine4411.1SOD1, CAT, NOS2, IL8
41cycloheximide4411.0TFF1, CAT
42bromodeoxyuridine4411.0ODC1, GAST, IL1RN, TFF1, CHGA
43estrogen4411.0DEFB4A
44alpha lipoic acid4411.0GHRL, CAT, SOD1, NOS2
45resveratrol44 59 11 2414.0TFF1, ODC1, GAST
46ptio4410.9CAT, NOS2, SOD1
47superoxide44 2411.9AKR1A1
48norepinephrine44 11 2412.8AREG, CHGA, GAST
49cimetidine44 28 1112.8AKR1A1, GAST, SCT, ADH7
50acetaldehyde44 28 2412.8CAT, GAST, AKR1A1, ADH7

GO Terms for genes affiliated with Gastritis

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16Gene Ontology
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Cellular components related to Gastritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.0IL1RN, S100A8, SOD1, TFF1, TFF2, GHRL
2extracellular regionGO:00557610.9ADH7, S100A8, IL8, CHGA, DEFB4A, GHRL
3peroxisomeGO:00577710.7NOS2, SOD1, CAT

Biological processes related to Gastritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1G-protein coupled receptor signaling pathwayGO:00718610.8GAST, GHRL, DEFB4A, IL8
2digestionGO:00758610.6TFF2, TFF1, PGC
3response to ethanolGO:04547110.4SOD1, ADH7, S100A8

Products for genes affiliated with Gastritis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gastritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet