MCID: GST090
MIFTS: 28

Gastroduodenal Crohn's Disease

Categories: Gastrointestinal diseases

Aliases & Classifications for Gastroduodenal Crohn's Disease

MalaCards integrated aliases for Gastroduodenal Crohn's Disease:

Name: Gastroduodenal Crohn's Disease 12 14
Upper Gi Crohn's Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060191
ICD10 32 K50.0

Summaries for Gastroduodenal Crohn's Disease

Disease Ontology : 12 An inflammatory bowel disease characterized by inflammation located in stomach and located in duodenum, has symptom nausea, has symptom vomiting, has symptom weight loss and has symptom loss of appetite.

MalaCards based summary : Gastroduodenal Crohn's Disease, also known as upper gi crohn's disease, is related to fungal esophagitis and bladder calculus, and has symptoms including nausea, vomiting and weight loss. An important gene associated with Gastroduodenal Crohn's Disease is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2). Affiliated tissues include stomach, duodenum and small intestine, and related phenotype is homeostasis/metabolism.

Related Diseases for Gastroduodenal Crohn's Disease

Diseases related to Gastroduodenal Crohn's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 fungal esophagitis 10.1 ATP12A ATP4A
2 bladder calculus 10.1 ATP12A ATP4A
3 gastrointestinal neuroendocrine benign tumor 10.1 ATP12A ATP4A
4 gastric neuroendocrine neoplasm 10.1 ATP12A ATP4A
5 neonatal candidiasis 10.1 ATP12A ATP4A
6 photoallergic dermatitis 10.1 ATP12A ATP4A
7 squamous papillomatosis 10.1 ATP12A ATP4A
8 acute laryngitis 10.1 ATP12A ATP4A
9 toxic megacolon 10.1 ATP12A ATP4A
10 aspiration pneumonitis 10.1 ATP12A ATP4A
11 gastric antral vascular ectasia 10.1 ATP12A ATP4A
12 esophageal candidiasis 10.1 ATP12A ATP4A
13 postsurgical hypothyroidism 10.1 ATP12A ATP4A
14 rumination disorder 10.1 ATP12A ATP4A
15 laryngeal disease 10.1 ATP12A ATP4A
16 duodenitis 10.1 ATP12A ATP4A
17 congenital disorder of deglycosylation 10.0 ATP12A ATP4A
18 bile reflux 10.0 ATP12A ATP4A
19 active peptic ulcer disease 10.0 ATP12A ATP4A
20 dyskinesia of esophagus 10.0 ATP12A ATP4A
21 ischemic neuropathy 10.0 ATP12A ATP4A
22 anismus 10.0 ATP12A ATP4A
23 capillary disease 10.0 ATP12A ATP4A
24 peptic esophagitis 10.0 ATP12A ATP4A
25 duodenal disease 10.0 ATP12A ATP4A
26 hernia, hiatus 10.0 ATP12A ATP4A
27 esophageal atresia/tracheoesophageal fistula 10.0 ATP12A ATP4A
28 laryngitis 10.0 ATP12A ATP4A
29 laryngeal tuberculosis 10.0 ATP12A ATP4A
30 lymphocytic colitis 10.0 ATP12A ATP4A
31 chronic intestinal vascular insufficiency 10.0 ATP12A ATP4A
32 clostridium difficile colitis 10.0 ATP12A ATP4A
33 lower urinary tract calculus 10.0 ATP12A ATP4A
34 diarrhea 1, secretory chloride, congenital 10.0 ATP12A ATP4A
35 polyposis, skin pigmentation, alopecia, and fingernail changes 10.0 ATP12A ATP4A
36 aspiration pneumonia 10.0 ATP12A ATP4A
37 chronic laryngitis 10.0 ATP12A ATP4A
38 esophageal varix 10.0 ATP12A ATP4A
39 eosinophilic gastritis 10.0 ATP12A ATP4A
40 myopathy, x-linked, with excessive autophagy 10.0 ATP12A ATP4A
41 esophagus adenocarcinoma 9.9 ATP12A ATP4A
42 jejunoileitis 9.9 ATP12A ATP4A
43 pneumatosis cystoides intestinalis 9.9 ATP12A ATP4A
44 superior mesenteric artery syndrome 9.9 ATP12A ATP4A
45 functional gastric disease 9.9 ATP12A ATP4A
46 lateral medullary syndrome 9.9 ATP12A ATP4A
47 paine syndrome 9.9 ATP12A ATP4A
48 cloacal exstrophy 9.8 ATP12A ATP4A
49 peptic ulcer perforation 9.8 ATP12A ATP4A
50 esophageal disease 9.8 ATP12A ATP4A

Graphical network of the top 20 diseases related to Gastroduodenal Crohn's Disease:



Diseases related to Gastroduodenal Crohn's Disease

Symptoms & Phenotypes for Gastroduodenal Crohn's Disease

Symptoms:

12
  • nausea
  • vomiting
  • weight loss
  • loss of appetite

MGI Mouse Phenotypes related to Gastroduodenal Crohn's Disease:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.02 ATP12A ATP4A GIF NOD2 TGM2

Drugs & Therapeutics for Gastroduodenal Crohn's Disease

Search Clinical Trials , NIH Clinical Center for Gastroduodenal Crohn's Disease

Genetic Tests for Gastroduodenal Crohn's Disease

Anatomical Context for Gastroduodenal Crohn's Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Gastroduodenal Crohn's Disease:

18
Stomach, Duodenum

MalaCards organs/tissues related to Gastroduodenal Crohn's Disease:

38
Small Intestine

Publications for Gastroduodenal Crohn's Disease

Articles related to Gastroduodenal Crohn's Disease:

(show all 20)
# Title Authors Year
1
Isolated gastroduodenal Crohn's disease in a septuagenarian man. ( 24756277 )
2014
2
Infliximab treatment of massive upper gastrointestinal bleeding in gastroduodenal Crohn's disease. ( 19115158 )
2008
3
Isolated gastroduodenal Crohn's disease presenting with acute pancreatitis. ( 21960926 )
2008
4
Gastroduodenal Crohn's disease and pancreatitis. ( 21960927 )
2008
5
Gastroduodenal Crohn's disease is associated with NOD2/CARD15 gene polymorphisms, particularly L1007P homozygosity. ( 16416181 )
2005
6
Treatment of gastroduodenal Crohn's disease. ( 15711048 )
2005
7
Gastroduodenal Crohn's disease. ( 15605018 )
2004
8
Gastroduodenal Crohn's disease: medical management. ( 12769447 )
2003
9
Severe gastroduodenal Crohn's disease: surgical treatment. ( 12769448 )
2003
10
Gastroduodenal Crohn's disease. ( 16278730 )
2003
11
Long-term outcome of endoscopic balloon dilation in obstructive gastroduodenal Crohn's disease. ( 9360875 )
1997
12
Gastroduodenal Crohn's disease: the focus is on focality. ( 9041268 )
1997
13
Repeated hydrostatic balloon dilation in obstructive gastroduodenal Crohn's disease. ( 1916177 )
1991
14
Gastroduodenal Crohn's disease in childhood. ( 2809935 )
1989
15
The diagnosis of gastroduodenal Crohn's disease by endoscopic biopsy. ( 2617164 )
1989
16
Clinical features of gastroduodenal Crohn's disease in adolescents. ( 2709248 )
1989
17
The surgical treatment of gastroduodenal Crohn's disease. ( 4073768 )
1985
18
Gastric retention of enteric-coated sulfasalazine tablets. A complication of gastroduodenal Crohn's disease. ( 6149106 )
1984
19
Gastroduodenal Crohn's disease. ( 6726063 )
1984
20
Gastroduodenal Crohn's disease. Differential diagnosis and treatment. ( 6647159 )
1983

Variations for Gastroduodenal Crohn's Disease

Expression for Gastroduodenal Crohn's Disease

Search GEO for disease gene expression data for Gastroduodenal Crohn's Disease.

Pathways for Gastroduodenal Crohn's Disease

GO Terms for Gastroduodenal Crohn's Disease

Biological processes related to Gastroduodenal Crohn's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.37 NOD2 TGM2
2 ion transport GO:0006811 9.33 ATP12A ATP4A GIF
3 potassium ion transport GO:0006813 9.32 ATP12A ATP4A
4 sodium ion transport GO:0006814 9.26 ATP12A ATP4A
5 proton transport GO:0015992 8.96 ATP12A ATP4A
6 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.62 ATP12A ATP4A

Molecular functions related to Gastroduodenal Crohn's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
2 hydrogen:potassium-exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Gastroduodenal Crohn's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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