MCID: GST039
MIFTS: 46

Gastroduodenitis malady

Gastrointestinal diseases category

Summaries for Gastroduodenitis

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32MalaCards
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MalaCards: Gastroduodenitis is related to duodenitis and duodenal ulcer. An important gene associated with Gastroduodenitis is OMP (olfactory marker protein), and among its related pathways are O-linked glycosylation of mucins and Gastric acid secretion. The compounds ranitidine and pge2 have been mentioned in the context of this disorder. Affiliated tissues include liver, t cells and brain, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Gastroduodenitis

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

gastroduodenitis 8 10 60


External Ids:

Disease Ontology8 DOID:8644
ICD9CM27 535.4
ICD1025 K29.9

Related Diseases for Gastroduodenitis

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17GeneCards, 18GeneDecks
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Diseases related to Gastroduodenitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 144)
idRelated DiseaseScoreTop Affiliating Genes
1duodenitis30.7GAST, S100A8
2duodenal ulcer30.6HRH2, GAST, SCT, S100A8
3peptic ulcer30.5S100A8, SCT, GAST, SST, HRH2, PTGS1
4pancreatitis30.3SCT, SST
5gastritis30.2GAST, SCT, S100A8
6arthritis30.2S100A8, HRH2, PTGS1
7familial adenomatous polyposis30.2MUC2, MUC6, PTGS1
8gastric ulcer30.2PTGS1, HRH2, GAST, S100A8
9esophagitis30.1HRH2, GAST, S100A8
10dyspepsia30.1HRH2, MLN, MLNR, GAST
11duodenogastric reflux30.0MLN, GAST
12gastroparesis30.0GAST, MLNR, MLN
13zollinger-ellison syndrome30.0SCT, GAST, SST, HRH2
14adenocarcinoma30.0S100A8, SCT, GAST, PRDX6, SST, MUC2
15hepatitis29.7HRH2
16obesity29.7MLN, SERPINA6
17dumping syndrome29.7MLN, SST
18ischemia29.7HRH2, MLN
19atrophic gastritis29.7S100A8, SCT, GAST, SST
20angiodysplasia29.7SST
21gastric adenocarcinoma29.7HRH2, MUC2, GAST, S100A8
22gastrinoma29.7SST, GAST, SCT
23cystic fibrosis29.7S100A8, SCT, OMP, MUC2, MUC6, MUC3A
24adenoma29.7S100A8, SCT, GAST, SST, MUC2, MUC6
25intussusception10.4
26ulcerative colitis10.2
27amyloidosis10.1
28obstructive jaundice10.1
29osteoarthritis10.1
30peutz-jeghers syndrome10.1
31rheumatoid arthritis10.1
32deficiency anemia10.0
33crohn's disease10.0
34alcoholic pancreatitis10.0
35gastrointestinal stromal tumor10.0
36iron deficiency anemia10.0
37peptic ulcer perforation10.0
38duodenal obstruction10.0
39plasmacytoma10.0
40tuberculosis10.0
41diabetic autonomic neuropathy10.0MLNR
42inflammatory bowel disease10.0MUC2
43constipation10.0MLN
44coronary heart disease10.0CYBA
45pancreas disease10.0GAST, SCT
46lung cancer10.0SST
47cholangiocarcinoma10.0MUC2, SCT
48steatorrhea10.0SCT, SST
49gallbladder disease10.0MLNR, MLN, MUC2
50microinvasive gastric cancer10.0S100A8, GAST, MUC2

Graphical network of the top 20 diseases related to Gastroduodenitis:



Diseases related to gastroduodenitis

Clinical Features for Gastroduodenitis

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Drugs & Therapeutics for Gastroduodenitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Gastroduodenitis

Drug clinical trials:

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Search NIH Clinical Center for Gastroduodenitis

Search CenterWatch for Gastroduodenitis

Genetic Tests for Gastroduodenitis

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Anatomical Context for Gastroduodenitis

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32MalaCards
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MalaCards organs/tissues related to Gastroduodenitis:

32
Liver, T cells, Brain, Pancreas

Animal Models for Gastroduodenitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Gastroduodenitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.8CPB2, GAST, PRDX6, OMP, SST, MUC2

Publications for Gastroduodenitis

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50PubMed
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Articles related to Gastroduodenitis:

(show top 50)    (show all 218)
idTitleAuthorsYear
1
Clinical features and treatment of ulcerative colitis-related severe gastroduodenitis and enteritis with massive bleeding after colectomy. (24105365)
2013
2
Risk factors of gastroparesis syndrome after abdominal non-gastroduodenal operation and its prevention. (23711714)
2013
3
Diffuse Gastroduodenal Metastasis from Cutaneous Malignant Melanoma Presenting as Amelanotic "Volcano-Like" Ulcers. (23775060)
2013
4
Diffuse gastroduodenitis and enteritis associated with ulcerative colitis and concomitant cytomegalovirus reactivation after total colectomy: report of a case. (22965486)
2013
5
Gastroduodenal intussusception resulting from large hyperplastic polyp. (23094233)
2012
6
Education and Imaging: Gastrointestinal: gastroduodenal involvement of ALK-positive anaplastic large cell lymphoma. (21488949)
2011
7
Stress controversies: post-traumatic stress disorder, hippocampal volume, gastroduodenal ulceration*. (20973838)
2011
8
Tubercular gastroduodenal abscess presenting with obstructive jaundice: diagnosis with EUS-guided FNA. (21962989)
2011
9
Gastroduodenitis and Helicobacter pylori in Nigerians: histopathological assessment of endoscopic biopsies. (20037622)
2009
10
The relationship among IL-10, TNF gene polymorphisms, Helicobacter pylori infection and gastroduodenal diseases in Hubei Han ethnic]. (19957794)
2009
11
Clinical challenges and images in GI. Peutz-Jeghers syndrome with gastroduodenal intussusception secondary to gastric cancer. (19167388)
2009
12
Gastroduodenal involvement in patients with familial adenomatous polyposis. Prospective study of the nature and evolution of polyps: evaluation of the treatment and surveillance methods applied. (19357520)
2009
13
Prevalence and risk factors of atrophic gastritis and intestinal metaplasia in a Korean population without significant gastroduodenal disease. (18665932)
2008
14
Association of polymorphism of TLR4 and CD14 genes with gastroduodenal diseases in Japan. (19847953)
2007
15
Gastric outlet obstruction due to gastroduodenal eosinophilic gastroenteritis. (17614041)
2007
16
Association of Helicobacter pylori infection with gastroduodenal disease, epidemiologic factors and iron-deficiency anemia in Turkish children undergoing endoscopy, and impact on growth. (18045286)
2007
17
Effects of the myeloperoxidase 463 gene polymorphisms on development of atrophy in H pylori infected or noninfected gastroduodenal disease. (17451207)
2007
18
Diffuse gastroduodenitis and pouchitis associated with ulcerative colitis. (17007066)
2006
19
Allele variants of the cytochrome P450 2C9 genotype in white subjects from The Netherlands with serious gastroduodenal ulcers attributable to the use of NSAIDs. (17157122)
2006
20
Giant gastroduodenal artery pseudoaneurysm due to polyarteritis nodosa as a cause of obstructive jaundice: imaging findings and coil embolization results. (16132389)
2005
21
Down-regulation of secretory leukocyte protease inhibitor expression in gastric mucosa is a general phenomenon in Helicobacter pylori-related gastroduodenal diseases. (15812165)
2004
22
Gastroduodenal tolerability of lumiracoxib vs placebo and naproxen: a pilot endoscopic study in healthy male subjects. (12950426)
2003
23
Gastroduodenal safety of cyclooxygenase-2 inhibitors. (14529400)
2003
24
Helicobacter pylori stimulates inducible nitric oxide synthase in diverse topographical patterns in various gastroduodenal disorders. (12741449)
2003
25
An evaluation of the impact of supplementation with antioxidant vitamins on oxidation stress parameters in children with chronic recurrent gastroduodenitis. (11782674)
2002
26
Pseudoaneurysm of gastroduodenal artery associated with mitral valve prolapse presenting as haemobilia. (11963328)
2001
27
Geographic differences and the role of cagA gene in gastroduodenal diseases associated with Helicobacter pylori infection. (11685943)
2001
28
Role of cytokines in the metabolism of the extracellular matrix carbohydrate-protein components in patients of various ages with gastroduodenal ulcer]. (11692712)
2001
29
Epidermal growth factor and its receptor in chronic active gastritis and gastroduodenal ulcer before and after Helicobacter pylori eradication. (11552919)
2001
30
Prevalence of gastroduodenitis and Helicobacter pylori infection in a general population sample: relations to symptomatology and life-style. (10961710)
2000
31
Acute gastroduodenal peptic ulcer perforation: contrast-enhanced and thin-section spiral CT findings in 10 patients. (10390552)
1999
32
Gastroduodenal intussusception secondary to a gastric leiomyoma resulting in an ulceration. (10344450)
1999
33
Effect of chronic duodenal ulceration and its treatment with lanzoprazole or sucralfate on gastroduodenal mucosal protein turnover and TGF-alpha, bFGF, and EGF receptor expression in humans. (9881512)
1998
34
Two young Somalians with gastric outlet obstruction as a first manifestation of gastroduodenal tuberculosis. (9160204)
1997
35
Further classification of dysmotility-like dyspepsia by interdigestive gastroduodenal manometry and plasma motilin level. (9068474)
1997
36
Duodenal obstruction: diagnosis by gastroduodenal manometry. (9033545)
1997
37
Somatic mutations of the adenomatous polyposis coli gene in gastroduodenal tumors from patients with familial adenomatous polyposis. (7606737)
1995
38
Treatment of severe gastroduodenal hemorrhages with the analog of somatostatin (octreotide: SMS 201-995)]. (7875429)
1994
39
Omeprazole versus ranitidine plus somatostatin in the treatment of severe gastroduodenal bleeding: a prospective, randomized, controlled trial. (7913348)
1994
40
Interleukin-8 expression in Helicobacter pylori infected, normal, and neoplastic gastroduodenal mucosa. (8132812)
1994
41
Collagenous gastroduodenitis on collagenous colitis. (2209504)
1990
42
Chloroquine phosphate-induced gastroduodenitis. (3234691)
1988
43
Gastrointestinal occult hemorrhage and gastroduodenitis in cow's milk protein intolerance. (6707841)
1984
44
Gastric secretion, gastroduodenal histological changes, and serum gastrin in chronic alcoholic pancreatitis. (7072677)
1982
45
Psychological distress in duodenal ulcer and acute gastroduodenitis. A controlled study. (7172957)
1982
46
Gastroduodenal fistula in the Zollinger-Ellison syndrome. (537964)
1979
47
Gastroduodenitis as the cause of gastroduodenal ulcer. (5352279)
1969
48
Peptic ulcer perforation of the gastroduodenal artery complex: clinical features and operative control. (4883483)
1969
49
Liver changes in chronic gastroduodenitis. (13690074)
1960
50
Gastroduodenal intussuception due to a myoma. (13621194)
1959

Genetic Variations for Gastroduodenitis

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Expression for genes affiliated with Gastroduodenitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gastroduodenitis

Search GEO for disease gene expression data for Gastroduodenitis.

Pathways for genes affiliated with Gastroduodenitis

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53Reactome, 29KEGG, 37NCBI BioSystems Database
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Pathways related to Gastroduodenitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3MUC2, MUC6, MUC3A
210.3GAST, SST, HRH2
3
Hide members
10.2SCT, MLNR, MLN, SST, HRH2

Compounds for genes affiliated with Gastroduodenitis

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Gastroduodenitis according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
1ranitidine44 28 11 2413.8HRH2, MLN, SCT
2pge24410.8CPOX, SST
3dexamethasone44 49 28 1113.7S100A8, MUC2, CYBA
4pepsinogen4410.7SCT, GAST, HRH2
5loxiglumide4410.7SCT, GAST, SST
6enprostil28 4411.7GAST, SST, HRH2
7glutamate4410.7GAST, SCT
8pantoprazole44 49 11 2413.7GAST, SST, HRH2
9bethanechol44 28 1112.7SST, MLN, GAST
10amoxicillin44 49 1112.7S100A8, GAST, HRH2
11domperidone44 28 1112.7GAST, MLN, SST, HRH2
12oxyntomodulin44 5911.7SCT, GAST, MLN, SST
13cisapride44 28 1112.7HRH2, MLN, MLNR
14pirenzepine44 28 1112.7HRH2, SST, GAST
15em 5234410.7MLNR, MLN
16ranitidine bismuth citrate4410.7GAST, HRH2
17octreotide44 59 28 1113.7SCT, GAST, MLN, SST
18celecoxib44 59 28 49 11 2415.7GAST, HRH2, PTGS1, CPOX
19lafutidine4410.7HRH2, SST, MLN, GAST, SCT
20trimebutine4410.7GAST, MLN
21clarithromycin44 1111.7S100A8, GAST, HRH2
22nizatidine44 1111.6HRH2, GAST
23atropine44 28 1112.6SCT, GAST, MLN, SST, HRH2
24taurodeoxycholate4410.6SST, SCT
25acetaminophen44 2 49 11 2414.6GAST, MLN, HRH2, PTGS1
26thyroxine44 2411.6SCT, GAST, MLN, SST, SERPINA6
27acth4410.6SCT, GAST, MLN, SST, SERPINA6
28omeprazole44 28 49 11 2414.6S100A8, SCT, GAST, MLN, SST, HRH2
29histamine44 28 2412.6S100A8, SCT, GAST, MLN, SST, HRH2
30glucose4410.6SCT, GAST, MLN, MUC2, SERPINA6, CPOX
315-hydroxytryptamine4410.5GAST, MLN, SST, HRH2
32acetylcholine44 49 28 11 2414.5SCT, GAST, MLN, SST, HRH2
33isoproterenol44 1111.5SCT, GAST, SST, HRH2
34hydrogen44 2411.5SCT, GAST, MLN, PRDX6, HRH2, CPOX
35prostaglandin4410.5SCT, HRH2, PTGS1, CPOX
36adenylate4410.5SCT, GAST, MLN, SST, HRH2, SERPINA6
37famotidine44 2 11 2413.5GAST, MLN, HRH2
38heme28 11 2412.5PRDX6, CYBA, PTGS1, CPOX
39serine4410.5S100A8, SCT, MLN, PRDX6, MUC2, HRH2
40oligonucleotide4410.4S100A8, SCT, MUC2, MUC6, MUC3A, CYBA
41caerulein4410.4SCT, MLN
42cimetidine44 28 1112.4HRH2, GAST, SCT
43alanine4410.4S100A8, GAST, MLNR, MLN, PTGS1, SERPINA6
44cholesterol44 28 11 2413.4S100A8, MLN, MUC2, MUC6, MUC3A, CYBA
45minigastrin4410.4GAST, SST
46diclofenac44 28 49 1113.3CPOX, PTGS1, HRH2
47arginine4410.3SCT, MLN, SST, SERPINA6, CPB2, CPOX
48glp-1 (7-36)amide4410.3SCT, GAST
49calcium44 49 11 2413.2MLN, MLNR, GAST, SCT, S100A8, OMP
50dopamine44 28 11 2412.9SCT, GAST, MLNR, MLN, SST

GO Terms for genes affiliated with Gastroduodenitis

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16Gene Ontology
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Cellular components related to Gastroduodenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.1S100A8, SCT, GAST, MLN, SST, MUC6
2Golgi lumenGO:00579610.0MUC2, MUC6, MUC3A

Biological processes related to Gastroduodenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1digestionGO:00758610.3MLNR, MUC3A, SST
2O-glycan processingGO:01626610.2MUC2, MUC6, MUC3A
3G-protein coupled receptor signaling pathwayGO:00718610.2GAST, MLNR, MLN, SST
4maintenance of gastrointestinal epitheliumGO:03027710.1MUC3A, MUC6

Molecular functions related to Gastroduodenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.2SST, MLN, GAST, SCT

Products for genes affiliated with Gastroduodenitis

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Sources for Gastroduodenitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet