MCID: GST039
MIFTS: 46

Gastroduodenitis malady

Gastrointestinal diseases category

Summaries for Gastroduodenitis

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32MalaCards
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MalaCards: Gastroduodenitis is related to duodenitis and duodenal ulcer. An important gene associated with Gastroduodenitis is OMP (olfactory marker protein), and among its related pathways are O-linked glycosylation of mucins and Gastric acid secretion. The compounds ranitidine and pge2 have been mentioned in the context of this disorder. Affiliated tissues include liver, t cells and brain, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Gastroduodenitis

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

gastroduodenitis 8 10 60


External Ids:

Disease Ontology8 DOID:8644
ICD9CM27 535.4
ICD1025 K29.9

Related Diseases for Gastroduodenitis

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17GeneCards, 18GeneDecks
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Diseases related to Gastroduodenitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 144)
idRelated DiseaseScoreTop Affiliating Genes
1duodenitis30.7GAST, S100A8
2duodenal ulcer30.6HRH2, GAST, SCT, S100A8
3peptic ulcer30.5S100A8, SCT, GAST, SST, HRH2, PTGS1
4pancreatitis30.3SCT, SST
5gastritis30.2GAST, SCT, S100A8
6arthritis30.2S100A8, HRH2, PTGS1
7familial adenomatous polyposis30.2MUC2, MUC6, PTGS1
8gastric ulcer30.2PTGS1, HRH2, GAST, S100A8
9esophagitis30.1HRH2, GAST, S100A8
10dyspepsia30.1HRH2, MLN, MLNR, GAST
11duodenogastric reflux30.0MLN, GAST
12gastroparesis30.0GAST, MLNR, MLN
13zollinger-ellison syndrome30.0SCT, GAST, SST, HRH2
14adenocarcinoma30.0S100A8, SCT, GAST, PRDX6, SST, MUC2
15hepatitis29.7HRH2
16obesity29.7MLN, SERPINA6
17dumping syndrome29.7MLN, SST
18ischemia29.7HRH2, MLN
19atrophic gastritis29.7S100A8, SCT, GAST, SST
20angiodysplasia29.7SST
21gastric adenocarcinoma29.7HRH2, MUC2, GAST, S100A8
22gastrinoma29.7SST, GAST, SCT
23cystic fibrosis29.7S100A8, SCT, OMP, MUC2, MUC6, MUC3A
24adenoma29.7S100A8, SCT, GAST, SST, MUC2, MUC6
25intussusception10.4
26ulcerative colitis10.2
27amyloidosis10.1
28obstructive jaundice10.1
29osteoarthritis10.1
30peutz-jeghers syndrome10.1
31rheumatoid arthritis10.1
32deficiency anemia10.0
33crohn's disease10.0
34alcoholic pancreatitis10.0
35gastrointestinal stromal tumor10.0
36iron deficiency anemia10.0
37peptic ulcer perforation10.0
38duodenal obstruction10.0
39plasmacytoma10.0
40tuberculosis10.0
41diabetic autonomic neuropathy10.0MLNR
42inflammatory bowel disease10.0MUC2
43constipation10.0MLN
44coronary heart disease10.0CYBA
45pancreas disease10.0GAST, SCT
46lung cancer10.0SST
47cholangiocarcinoma10.0MUC2, SCT
48steatorrhea10.0SCT, SST
49gallbladder disease10.0MLNR, MLN, MUC2
50microinvasive gastric cancer10.0S100A8, GAST, MUC2

Graphical network of the top 20 diseases related to Gastroduodenitis:



Diseases related to gastroduodenitis

Clinical Features for Gastroduodenitis

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Drugs & Therapeutics for Gastroduodenitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Gastroduodenitis

Drug clinical trials:

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Search NIH Clinical Center for Gastroduodenitis

Search CenterWatch for Gastroduodenitis

Genetic Tests for Gastroduodenitis

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Anatomical Context for Gastroduodenitis

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32MalaCards
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MalaCards organs/tissues related to Gastroduodenitis:

32
Liver, T cells, Brain, Pancreas

Animal Models for Gastroduodenitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Gastroduodenitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.8CPB2, GAST, PRDX6, OMP, SST, MUC2

Publications for Gastroduodenitis

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50PubMed
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Articles related to Gastroduodenitis:

(show top 50)    (show all 218)
idTitleAuthorsYear
1
Topical application of ankaferd hemostat in a patient with gastroduodenal amyloidosis complicated with gastrointestinal bleeding. (23751610)
2013
2
An assessment of radiologically inserted transoral and transgastric gastroduodenal stents to treat malignant gastric outlet obstruction. (23456310)
2013
3
Gastroduodenal neuroendocrine neoplasms including gastrinoma - management guidelines (recommended by the Polish Network of Neuroendocrine Tumours). (24431117)
2013
4
A rare cause of gastrointestinal bleeding. Multiple myeloma with extramedullary gastroduodenal plasmacytoma. (23900105)
2013
5
Gastroduodenal stents are associated with more durable patency as compared to percutaneous endoscopic gastrojejunostomy in the palliation of malignant gastric outlet obstruction. (23687600)
2012
6
Comparison of PCR with other diagnostic techniques for the detection of H. pylori infection in patients presenting with gastroduodenal symptons in Nigeria. (21686132)
2011
7
Heat shock protein 27: induction by gastroduodenal reflux in vivo and augmentation of human esophageal mucosal cell growth in vitro. (20304146)
2010
8
Novel single nucleotide polymorphism of the VEGF gene as a risk predictor for gastroduodenal ulcers. (19120886)
2008
9
Gastroduodenitis associated with yttrium 90-microsphere selective internal radiation: an iatrogenic complication in need of recognition. (18976008)
2008
10
API2-MALT1 chimeric transcript-positive gastroduodenal MALT lymphoma with subsequent development of adenocarcinoma as a collision tumour over a clinical course of 7 years. (17542995)
2007
11
A historical perspective of Helicobacter gastroduodenitis and its complications. (17382281)
2007
12
A case of acute gastroduodenitis with cytomegalovirus infection in a healthy adult. (17827910)
2007
13
Proton-pump inhibitors are associated with a reduced risk for bleeding and perforated gastroduodenal ulcers attributable to non-steroidal anti-inflammatory drugs: a nested case-control study. (17521422)
2007
14
The effects of genetic polymorphisms of IL-1 and TNF-A on Helicobacter pylori-induced gastroduodenal diseases in Korea. (16579840)
2006
15
Role of pancreatic trypsin in chronic esophagitis induced by gastroduodenal reflux in rats. (16699853)
2006
16
Helicobacter pylori and gastroduodenal pathology: new threats of the old friend. (15634357)
2005
17
Mucosal proinflammatory cytokine and chemokine expression of gastroduodenal lesions in Crohn's disease. (15943853)
2005
18
cagA genotype and variants in Chinese Helicobacter pylori strains and relationship to gastroduodenal diseases. (14970249)
2004
19
Low molecular weight protein of Helicobacter pylori and its relation to gastroduodenal diseases. (12845945)
2003
20
Helicobacter pylori virulence genotypes in Portuguese children and adults with gastroduodenal pathology. (12627281)
2003
21
Erosive gastroduodenitis and Helicobacter pylori infection. (12824950)
2003
22
Gastroduodenal intussusception due to Peutz-Jeghers syndrome in infancy. (11956792)
2002
23
Gastroduodenal lesions in primary AL amyloidosis. (12297775)
2002
24
Helicobacter pylori vacA, iceA, and cagA status and pattern of gastritis in patients with malignant and benign gastroduodenal disease. (11316139)
2001
25
Gastric outlet obstruction caused by a giant gastroduodenal artery aneurysm: a case report. (11204812)
2001
26
Reduced incidence of gastroduodenal ulcers with celecoxib, a novel cyclooxygenase-2 inhibitor, compared to naproxen in patients with arthritis. (11316141)
2001
27
Severe iron deficiency anemia and asymptomatic nodular gastroduodenitis: an uncommon presentation of Helicobacter pylori infection in a child. (11261448)
2001
28
A model of combined gastroduodenitis and hyperlipidemia in rats. (11391412)
2001
29
Inducible nitric oxide synthase expression in gastroduodenal diseases infected with Helicobacter pylori. (11328364)
2001
30
Gastroduodenal lesions in familial adenomatous polyposis. (10955728)
2000
31
Specific inhibition of cyclooxygenase-2 with MK-0966 is associated with less gastroduodenal damage than either aspirin or ibuprofen. (10383505)
1999
32
Splenic infarction complicating ligation of a gastroduodenal artery aneurysm. (10436373)
1999
33
Vascular approach to gastroduodenal ulceration: new studies with endothelins and VEGF. (9753225)
1998
34
Histamine, xanthine oxidase generated oxygen-derived free radicals and Helicobacter pylori in gastroduodenal inflammation and ulceration. (9628263)
1998
35
Helicobacter gastroduodenitis: a serious infectious disease. (9167554)
1997
36
Secondary amyloidosis in patients with rheumatoid arthritis: diagnostic and prognostic value of gastroduodenal biopsy. (8624622)
1996
37
Effects of histamine H2-receptor blockers and dalargin on reparative processes gastroduodenal mucosa in patients with duodenal ulcer]. (9121092)
1996
38
Advanced gastroduodenal polyposis with ras mutations in a patient with familial adenomatous polyposis. (8387955)
1993
39
Effect of duodenal ulcer healing induced by omeprazole and ranitidine on the generation of gastroduodenal eicosanoids, platelet-activating factor, pepsinogen A, and gastrin in duodenal ulcer patients. (1736336)
1992
40
Interdigestive gastroduodenal motility and cycling of putative regulatory hormones in severe obesity. (1641580)
1992
41
Erythromycin accelerates gastric emptying by inducing antral contractions and improved gastroduodenal coordination. (1537520)
1992
42
Status of the glutathione system in gastroduodenal ulcers]. (1942982)
1991
43
Gastroduodenal reflux and non-ulcerous dyspepsia. Is it an accidental association?]. (1929203)
1991
44
Is gastroduodenitis a cause of chronic dyspepsia? (1896828)
1991
45
Secretin versus cimetidine in the therapy of active bleeding from peptic gastroduodenal lesions. A prospective, randomized, double-blind, multicentric study]. (2204225)
1990
46
Celiac artery and superior mesenteric artery insufficiency. Unusual cause of erosive gastroduodenitis. (7060896)
1982
47
Gastroduodenitis. A broader concept of peptic ulcer disease. (7418590)
1980
48
Surgical treatment of the dumping syndrome after gastroduodenal resection. (7451061)
1980
49
DUODENAL SUBMUCOSAL ISLET CELL ADENOMA AND CHRONIC GASTRODUODENITIS. (14225961)
1964
50
THE PRE- AND POSTOPERATIVE EMPLOYMENT OF A BRASSTIPPED GASTRODUODENAL TUBE AS AN AID IN THE SURGICAL TREATMENT OF DUODENAL OBSTRUCTION IN THE NEWBORN. (17858187)
1943

Genetic Variations for Gastroduodenitis

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Expression for genes affiliated with Gastroduodenitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gastroduodenitis

Search GEO for disease gene expression data for Gastroduodenitis.

Pathways for genes affiliated with Gastroduodenitis

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Sources:
53Reactome, 29KEGG, 37NCBI BioSystems Database
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Pathways related to Gastroduodenitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3MUC3A, MUC6, MUC2
210.3HRH2, SST, GAST
3
Hide members
10.2SCT, MLNR, MLN, SST, HRH2

Compounds for genes affiliated with Gastroduodenitis

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Gastroduodenitis according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
1ranitidine44 28 11 2413.8SCT, MLN, HRH2
2pge24410.8CPOX, SST
3dexamethasone44 49 28 1113.7MUC2, CYBA, S100A8
4pepsinogen4410.7SCT, GAST, HRH2
5loxiglumide4410.7SST, GAST, SCT
6enprostil28 4411.7SST, GAST, HRH2
7glutamate4410.7SCT, GAST
8pantoprazole44 49 11 2413.7HRH2, GAST, SST
9amoxicillin44 49 1112.7S100A8, GAST, HRH2
10bethanechol44 28 1112.7GAST, SST, MLN
11domperidone44 28 1112.7HRH2, SST, MLN, GAST
12ranitidine bismuth citrate4410.7GAST, HRH2
13oxyntomodulin44 5911.7MLN, SST, GAST, SCT
14cisapride44 28 1112.7MLNR, HRH2, MLN
15pirenzepine44 28 1112.7GAST, HRH2, SST
16octreotide44 59 28 1113.7SCT, SST, MLN, GAST
17celecoxib44 59 28 49 11 2415.7CPOX, HRH2, PTGS1, GAST
18lafutidine4410.7SST, MLN, GAST, SCT, HRH2
19trimebutine4410.7MLN, GAST
20clarithromycin44 1111.7S100A8, GAST, HRH2
21em 5234410.7MLN, MLNR
22nizatidine44 1111.6GAST, HRH2
23atropine44 28 1112.6HRH2, SCT, GAST, SST, MLN
24taurodeoxycholate4410.6SST, SCT
25acetaminophen44 2 49 11 2414.6MLN, GAST, PTGS1, HRH2
26thyroxine44 2411.6SCT, GAST, MLN, SST, SERPINA6
27acth4410.6MLN, SERPINA6, GAST, SCT, SST
28omeprazole44 28 49 11 2414.6S100A8, SST, MLN, HRH2, GAST, SCT
29histamine44 28 2412.6HRH2, SST, GAST, SCT, S100A8, MLN
30glucose4410.6SCT, GAST, CPOX, SERPINA6, MUC2, MLN
315-hydroxytryptamine4410.5MLN, GAST, HRH2, SST
32acetylcholine44 49 28 11 2414.5GAST, MLN, SST, SCT, HRH2
33isoproterenol44 1111.5HRH2, SST, GAST, SCT
34hydrogen44 2411.5SCT, MLN, HRH2, CPOX, PRDX6, GAST
35prostaglandin4410.5SCT, HRH2, PTGS1, CPOX
36adenylate4410.5MLN, SST, HRH2, SCT, SERPINA6, GAST
37famotidine44 2 11 2413.5HRH2, MLN, GAST
38heme28 11 2412.5CYBA, PTGS1, CPOX, PRDX6
39serine4410.5HRH2, S100A8, PTGS1, MUC2, PRDX6, SCT
40oligonucleotide4410.4S100A8, SCT, MUC2, MUC6, MUC3A, CYBA
41caerulein4410.4MLN, SCT
42cimetidine44 28 1112.4HRH2, SCT, GAST
43alanine4410.4MLNR, CPOX, S100A8, GAST, MLN, PTGS1
44cholesterol44 28 11 2413.4HRH2, CYBA, MUC3A, S100A8, MLN, MUC2
45minigastrin4410.4SST, GAST
46diclofenac44 28 49 1113.3CPOX, HRH2, PTGS1
47arginine4410.3CPOX, CPB2, SERPINA6, SST, MLN, SCT
48glp-1 (7-36)amide4410.3SCT, GAST
49calcium44 49 11 2413.2GAST, CPB2, HRH2, CYBA, MUC3A, SCT
50dopamine44 28 11 2412.9SCT, GAST, MLNR, MLN, SST

GO Terms for genes affiliated with Gastroduodenitis

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16Gene Ontology
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Cellular components related to Gastroduodenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.1SCT, GAST, MLN, SST, MUC6, MUC3A
2Golgi lumenGO:00579610.0MUC3A, MUC6, MUC2

Biological processes related to Gastroduodenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1digestionGO:00758610.3MUC3A, SST, MLNR
2O-glycan processingGO:01626610.2MUC3A, MUC6, MUC2
3G-protein coupled receptor signaling pathwayGO:00718610.2SST, MLN, MLNR, GAST
4maintenance of gastrointestinal epitheliumGO:03027710.1MUC6, MUC3A

Molecular functions related to Gastroduodenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.2SST, MLN, GAST, SCT

Products for genes affiliated with Gastroduodenitis

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Sources for Gastroduodenitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet