MCID: GST039
MIFTS: 39

Gastroduodenitis malady

Gastrointestinal category

Summaries for Gastroduodenitis

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33MalaCards
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MalaCards: Gastroduodenitis is related to duodenal ulcer and gastric outlet obstruction. An important gene associated with Gastroduodenitis is OMP (olfactory marker protein), and among its related pathways are O-linked glycosylation of mucins and Gastric acid secretion. The compounds ranitidine and pge2 have been mentioned in the context of this disorder. Affiliated tissues include liver and t cells, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Gastroduodenitis

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 57SNOMED-CT, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal


Aliases & Descriptions:

gastroduodenitis 8 10 61


External Ids:

Disease Ontology8 DOID:8644
ICD9CM27 535.4
ICD1025 K29.9

Related Diseases for Gastroduodenitis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Gastroduodenitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 136)
idRelated DiseaseScoreTop Affiliating Genes
1duodenal ulcer30.6HRH2, GAST, SCT, S100A8
2gastric outlet obstruction30.4GAST, MLN
3adenoma30.3S100A8, SCT, GAST, SST, MUC2, MUC6
4arthritis30.2S100A8, HRH2, PTGS1
5familial adenomatous polyposis30.2MUC2, MUC6, PTGS1
6gastric ulcer30.2PTGS1, HRH2, GAST, S100A8
7dyspepsia30.2HRH2, MLN, MLNR, GAST
8duodenogastric reflux30.0MLN, GAST
9gastroparesis30.0GAST, MLNR, MLN
10zollinger-ellison syndrome30.0SCT, GAST, SST, HRH2
11pancreatitis, chronic30.0SCT, SST, MUC2, MUC6
12adenocarcinoma30.0S100A8, SCT, GAST, PRDX6, SST, MUC2
13dumping syndrome29.8MLN, SST
14atrophic gastritis29.8S100A8, SCT, GAST, SST
15angiodysplasia29.8SST
16gastrinoma29.8SST, GAST, SCT
17cystic fibrosis29.8S100A8, SCT, OMP, MUC2, MUC6, MUC3A
18intussusception10.4
19h. pylori infection10.3
20ulcerative colitis10.3
21amyloidosis10.2
22obstructive jaundice10.1
23osteoarthritis10.1
24peutz-jeghers syndrome10.1
25peutz–jeghers syndrome10.1
26deficiency anemia10.0
27alcoholic pancreatitis10.0
28gastrointestinal stromal tumor10.0
29iron deficiency anemia10.0
30peptic ulcer perforation10.0
31tuberculosis10.0
32pouchitis10.0
33diabetic autonomic neuropathy10.0MLNR
34duodenitis10.0GAST, S100A8
35inflammatory bowel disease10.0MUC2
36constipation10.0MLN
37hepatitis10.0HRH2
38coronary heart disease10.0CYBA
39pancreatitis10.0SCT, SST
40obesity10.0MLN, SERPINA6
41pancreas disease10.0GAST, SCT
42lung cancer10.0SST
43esophagitis10.0HRH2, GAST, S100A8
44cholangiocarcinoma10.0MUC2, SCT
45steatorrhea10.0SCT, SST
46gallbladder disease10.0MLNR, MLN, MUC2
47ischemia10.0HRH2, MLN
48microinvasive gastric cancer10.0S100A8, GAST, MUC2
49liver cirrhosis10.0MLN, SCT
50apudoma10.0SST

Graphical network of the top 20 diseases related to Gastroduodenitis:



Diseases related to gastroduodenitis

Clinical Features for Gastroduodenitis

Drugs & Therapeutics for Gastroduodenitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Gastroduodenitis

Drug clinical trials:

Search ClinicalTrials for Gastroduodenitis

Search NIH Clinical Center for Gastroduodenitis

Search CenterWatch for Gastroduodenitis

Genetic Tests for Gastroduodenitis

Anatomical Context for Gastroduodenitis

Sources:
33MalaCards
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MalaCards organs/tissues related to Gastroduodenitis:

33
Liver, T cells

Animal Models for Gastroduodenitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Gastroduodenitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.8CPB2, GAST, PRDX6, OMP, SST, MUC2

Publications for Gastroduodenitis

Sources:
51PubMed
See all sources

Articles related to Gastroduodenitis:

(show all 46)
idTitleAuthorsYear
1
Diffuse gastroduodenitis associated with ulcerative colitis: treatment by infliximab. (24164601)
2013
2
Clinical features and treatment of ulcerative colitis-related severe gastroduodenitis and enteritis with massive bleeding after colectomy. (24105365)
2013
3
Diffuse gastroduodenitis and enteritis associated with ulcerative colitis and concomitant cytomegalovirus reactivation after total colectomy: report of a case. (22965486)
2013
4
Collagenous gastroduodenitis. (21346601)
2011
5
Cryptococcal gastroduodenitis: a rare location of the disease. (19835991)
2010
6
Gastroduodenitis and Helicobacter pylori in Nigerians: histopathological assessment of endoscopic biopsies. (20037622)
2009
7
Gastroduodenitis associated with ulcerative colitis. (18373161)
2008
8
Chronic ulcerative gastroduodenitis as a first gastrointestinal manifestation of Hermansky-Pudlak syndrome in a 10-year-old child. (18473428)
2008
9
Gastroduodenitis associated with yttrium 90-microsphere selective internal radiation: an iatrogenic complication in need of recognition. (18976008)
2008
10
A historical perspective of Helicobacter gastroduodenitis and its complications. (17382281)
2007
11
A case of acute gastroduodenitis with cytomegalovirus infection in a healthy adult. (17827910)
2007
12
Wild-type and interleukin-10-deficient regulatory T cells reduce effector T-cell-mediated gastroduodenitis in Rag2-/- mice, but only wild-type regulatory T cells suppress Helicobacter pylori gastritis. (17353283)
2007
13
Diffuse gastroduodenitis and pouchitis associated with ulcerative colitis. (17007066)
2006
14
Clinical quiz: Helicobacter pylori gastroduodenitis. (15990645)
2005
15
Treatment strategies for patients with chronic ischemia of the lower limbs in erosive-ulcerous gastroduodenitis. (15097987)
2004
16
Erosive gastroduodenitis and Helicobacter pylori infection. (12824950)
2003
17
An evaluation of the impact of supplementation with antioxidant vitamins on oxidation stress parameters in children with chronic recurrent gastroduodenitis. (11782674)
2002
18
Severe iron deficiency anemia and asymptomatic nodular gastroduodenitis: an uncommon presentation of Helicobacter pylori infection in a child. (11261448)
2001
19
A model of combined gastroduodenitis and hyperlipidemia in rats. (11391412)
2001
20
Prevalence of gastroduodenitis and Helicobacter pylori infection in a general population sample: relations to symptomatology and life-style. (10961710)
2000
21
Analysis of gastroduodenitis and oesophagitis in relation to dyspeptic/reflux symptoms. (9586820)
1998
22
Helicobacter gastroduodenitis: a serious infectious disease. (9167554)
1997
23
Helicobacter gastroduodenitis. Routine treatment will lead to extra workload. (9365312)
1997
24
Serum cholinesterase activity in children with gastroduodenitis or peptic ulcer disease. (9581484)
1997
25
Aluminum phosphide-induced gastroduodenitis. (1397935)
1992
26
Helicobacter pylori, smoking and gastroduodenitis. (1797597)
1991
27
Is gastroduodenitis a cause of chronic dyspepsia? (1896828)
1991
28
Collagenous gastroduodenitis on collagenous colitis. (2209504)
1990
29
Chloroquine phosphate-induced gastroduodenitis. (3234691)
1988
30
A study of the correlation between endoscopic and histological diagnoses in gastroduodenitis. (3300278)
1987
31
Erosive gastroduodenitis with marked epithelial atypia after hepatic arterial infusion chemotherapy. (3923827)
1985
32
Gastrointestinal occult hemorrhage and gastroduodenitis in cow's milk protein intolerance. (6707841)
1984
33
Psychological distress in duodenal ulcer and acute gastroduodenitis. A controlled study. (7172957)
1982
34
Celiac artery and superior mesenteric artery insufficiency. Unusual cause of erosive gastroduodenitis. (7060896)
1982
35
Gastroduodenitis and peptic ulcer in a rural Liberian community. An endoscopic prospective study. (7281215)
1981
36
Is gastroduodenitis part of the spectrum of peptic ulcer disease? (7320465)
1981
37
Gastroduodenitis. A broader concept of peptic ulcer disease. (7418590)
1980
38
The esophagus in patients with gastroduodenitis and peptic ulcer disease. (628876)
1978
39
Proceedings: High level of fibrinolysis and low factor XIII in erosive haemorrhagic gastroduodenitis. (1081747)
1975
40
Erosive hemorrhagic gastroduodenitis with fibrinolysis and low factor XIII. (1081379)
1975
41
Chronic gastroduodenitis due to laundry bleach. (4851026)
1974
42
Gastroduodenitis as the cause of gastroduodenal ulcer. (5352279)
1969
43
DUODENAL SUBMUCOSAL ISLET CELL ADENOMA AND CHRONIC GASTRODUODENITIS. (14225961)
1964
44
Liver changes in chronic gastroduodenitis. (13690074)
1960
45
New antacid approach to therapy of duodenal and gastric ulcer and gastroduodenitis. (13251921)
1955
46
Eosinophilic gastroduodenitis with pyloric obstruction. (13249346)
1955

Genetic Variations for Gastroduodenitis

Expression for genes affiliated with Gastroduodenitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Gastroduodenitis

Search GEO for disease gene expression data for Gastroduodenitis.

Pathways for genes affiliated with Gastroduodenitis

Sources:
54Reactome, 30KEGG, 38NCBI BioSystems Database
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Pathways related to Gastroduodenitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3MUC2, MUC6, MUC3A
210.3GAST, SST, HRH2
3
Hide members
10.2SCT, MLNR, MLN, SST, HRH2

Compounds for genes affiliated with Gastroduodenitis

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience, 2BitterDB
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Compounds related to Gastroduodenitis according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
1ranitidine45 29 11 2413.8SCT, MLN, HRH2
2pge24510.8CPOX, SST
3dexamethasone45 50 29 1113.7MUC2, CYBA, S100A8
4pepsinogen4510.7SCT, GAST, HRH2
5loxiglumide4510.7SST, GAST, SCT
6enprostil29 4511.7SST, GAST, HRH2
7glutamate4510.7SCT, GAST
8pantoprazole45 50 11 2413.7HRH2, GAST, SST
9amoxicillin45 50 1112.7S100A8, GAST, HRH2
10bethanechol45 29 1112.7GAST, SST, MLN
11domperidone45 29 1112.7HRH2, SST, MLN, GAST
12ranitidine bismuth citrate4510.7GAST, HRH2
13oxyntomodulin45 6011.7MLN, SST, GAST, SCT
14cisapride45 29 1112.7MLNR, HRH2, MLN
15pirenzepine45 29 1112.7GAST, HRH2, SST
16octreotide45 60 29 1113.7SCT, SST, MLN, GAST
17celecoxib45 60 29 50 11 2415.7CPOX, HRH2, PTGS1, GAST
18lafutidine4510.7SST, MLN, GAST, SCT, HRH2
19trimebutine4510.7MLN, GAST
20clarithromycin45 1111.7S100A8, GAST, HRH2
21em 5234510.7MLN, MLNR
22nizatidine45 1111.6GAST, HRH2
23atropine45 29 1112.6HRH2, SCT, GAST, SST, MLN
24taurodeoxycholate4510.6SST, SCT
25acetaminophen45 2 50 11 2414.6MLN, GAST, PTGS1, HRH2
26thyroxine45 2411.6SCT, GAST, MLN, SST, SERPINA6
27acth4510.6MLN, SERPINA6, GAST, SCT, SST
28omeprazole45 29 50 11 2414.6S100A8, SST, MLN, HRH2, GAST, SCT
29histamine45 29 2412.6HRH2, SST, GAST, SCT, S100A8, MLN
30glucose4510.6SCT, GAST, CPOX, SERPINA6, MUC2, MLN
315-hydroxytryptamine4510.5MLN, GAST, HRH2, SST
32acetylcholine45 50 29 11 2414.5GAST, MLN, SST, SCT, HRH2
33isoproterenol45 1111.5HRH2, SST, GAST, SCT
34hydrogen45 2411.5SCT, MLN, HRH2, CPOX, PRDX6, GAST
35prostaglandin4510.5SCT, HRH2, PTGS1, CPOX
36adenylate4510.5MLN, SST, HRH2, SCT, SERPINA6, GAST
37famotidine45 2 11 2413.5HRH2, MLN, GAST
38heme29 11 2412.5CYBA, PTGS1, CPOX, PRDX6
39serine4510.5HRH2, S100A8, PTGS1, MUC2, PRDX6, SCT
40oligonucleotide4510.4S100A8, SCT, MUC2, MUC6, MUC3A, CYBA
41caerulein4510.4MLN, SCT
42cimetidine45 29 1112.4HRH2, SCT, GAST
43alanine4510.4MLNR, CPOX, S100A8, GAST, MLN, PTGS1
44cholesterol45 29 11 2413.4HRH2, CYBA, MUC3A, S100A8, MLN, MUC2
45minigastrin4510.4SST, GAST
46diclofenac45 29 50 1113.3CPOX, HRH2, PTGS1
47arginine4510.3CPOX, CPB2, SERPINA6, SST, MLN, SCT
48glp-1 (7-36)amide4510.3SCT, GAST
49calcium45 50 11 2413.2GAST, CPB2, HRH2, CYBA, MUC3A, SCT
50dopamine45 29 11 2412.9SCT, GAST, MLNR, MLN, SST

GO Terms for genes affiliated with Gastroduodenitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Gastroduodenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.1S100A8, SCT, GAST, MLN, SST, MUC6
2Golgi lumenGO:00579610.0MUC2, MUC6, MUC3A

Biological processes related to Gastroduodenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1digestionGO:00758610.3MUC3A, SST, MLNR
2O-glycan processingGO:01626610.2MUC3A, MUC6, MUC2
3G-protein coupled receptor signaling pathwayGO:00718610.2SST, MLN, MLNR, GAST
4maintenance of gastrointestinal epitheliumGO:03027710.1MUC6, MUC3A

Molecular functions related to Gastroduodenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.2SST, MLN, GAST, SCT

Products for genes affiliated with Gastroduodenitis

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Sources for Gastroduodenitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet