MCID: GST045
MIFTS: 53

Gastroenteritis malady

Gastrointestinal diseases category

Summaries for Gastroenteritis

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Sources:
9Disease Ontology, 35MedlinePlus, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Have you ever had the "stomach flu?" what you probably had was gastroenteritis - not a type of flu at all. gastroenteritis is an inflammation of the lining of the intestines caused by a virus, bacteria or parasites. viral gastroenteritis is the second most common illness in the u.s. the cause is often a norovirus infection. it spreads through contaminated food or water, and contact with an infected person. the best prevention is frequent hand washing. symptoms of gastroenteritis include diarrhea, abdominal pain, vomiting, headache, fever and chills. most people recover with no treatment. the most common problem with gastroenteritis is dehydration. this happens if you do not drink enough fluids to replace what you lose through vomiting and diarrhea. dehydration is most common in babies, young children, the elderly and people with weak immune systems. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Gastroenteritis, also known as cholera morbus, is related to eosinophilic gastroenteritis and esophagitis. An important gene associated with Gastroenteritis is IL5 (interleukin 5 (colony-stimulating factor, eosinophil)), and among its related pathways are IL4-mediated signaling events and Selected targets of GCR alpha. The drug erythromycin pwdr and the compounds unicap and sodium cromoglycate have been mentioned in the context of this disorder. Affiliated tissues include kidney, small intestine and testes.

Disease Ontology:9 A gastrointestinal system infectious disease that involves inflammation of the lining of the stomach and small and large intestines, which is caused by viruses, bacteria, or parasites. chemicals and drugs also cause gastroenteritis. the symptoms include diarrhea, loss of appetite, nausea, vomiting, cramps, and discomfort in the abdomen.

Wikipedia:66 Gastroenteritis or infectious diarrhea is a medical condition from inflammation (\"-itis\") of the... more...

Aliases & Classifications for Gastroenteritis

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 35MedlinePlus, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

gastroenteritis 9 11 46 35 63
cholera morbus 9 63
infectious colitis, enteritis and gastroenteritis 9


External Ids:

Disease Ontology9 DOID:2326
NCIt41 C34632
MeSH36 D005759

Related Diseases for Gastroenteritis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Gastroenteritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 199)
idRelated DiseaseScoreTop Affiliating Genes
1eosinophilic gastroenteritis31.7CSN1S1, IL5, CCL11
2esophagitis30.6IL5, CCL11
3eosinophilia30.5IL5, CCL11
4eosinophilic esophagitis30.5CCL11, IL5
5hypereosinophilic syndrome30.5CCL11, IL5
6arthritis30.4ANPEP, CSN1S1, ALB
7asthma30.3CSN1S1, IL5, CCL11
8diarrhea30.3ALB, CSN1S1
9food allergy30.3CCL11, IL5, CSN1S1
10bronchitis30.1CCL11, IL5
11dermatitis30.0BTD, IL5, CCL11
12hepatitis30.0ALB, HGF
13eosinophilic pneumonia29.9CCL11, IL5
14ulcerative colitis29.9ALB
15metabolic acidosis29.8BTD, ALB
16liver cirrhosis29.7ALB, CSN1S1, HGF
17atherosclerosis29.7ANPEP, CCL11, ALB
18pancreatitis10.4
19duodenitis10.4
20protein-losing enteropathy10.3
21irritable bowel syndrome10.3
22reactive arthritis10.2
23pyloric stenosis10.2
24blindness10.2
25cryptosporidiosis10.2
26listeriosis10.2
27duodenal obstruction10.2
28dysentery10.2
29strongyloidiasis10.1IL5
30common cold10.1CCL11
31folliculitis10.1CCL11
32pellagra10.1CSN1S1
33crohn's disease10.1
34acute pancreatitis10.1
35intussusception10.1
36cholangitis10.1
37inflammatory bowel disease10.1
38peritonitis10.1
39eosinophilic enteropathy10.1
40bacteremia10.1
41bronchiolitis10.1IL5, CCL11
42chronic eosinophilic pneumonia10.1IL5, CCL11
43giant papillary conjunctivitis10.1CCL11, IL5
44allergic conjunctivitis10.1CCL11, IL5
45keratoconjunctivitis10.1CCL11, IL5
46pulmonary eosinophilia10.1IL5, CCL11
47vernal keratoconjunctivitis10.1CCL11, IL5
48sinusitis10.1CCL11, IL5
49bullous pemphigoid10.1IL5, CCL11
50mycosis fungoides10.1ANPEP, IL5

Graphical network of the top 20 diseases related to Gastroenteritis:



Diseases related to gastroenteritis

Symptoms for Gastroenteritis

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Drugs & Therapeutics for Gastroenteritis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Gastroenteritis

Drug clinical trials:

Search ClinicalTrials for Gastroenteritis

Search NIH Clinical Center for Gastroenteritis

Search CenterWatch for Gastroenteritis

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Gastroenteritis

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Anatomical Context for Gastroenteritis

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Sources:
34MalaCards
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MalaCards organs/tissues related to Gastroenteritis:

34
Kidney, Small intestine, Testes, Colon, Liver, Bone, T cells, Pancreas, Tonsil, Bone marrow, Skin, Thyroid, Lung, Eye, Pituitary

Animal Models for Gastroenteritis or affiliated genes

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Publications for Gastroenteritis

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Sources:
53PubMed
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Articles related to Gastroenteritis:

(show top 50)    (show all 870)
idTitleAuthorsYear
1
Severe acute rotavirus gastroenteritis in children less than 5 years in southern ghana: 2006-2011. (24343622)
2014
2
Hospital-based Surveillance for Rotavirus Gastroenteritis in Children Younger Than 5 Years of Age in Ethiopia: 2007-2012. (24343610)
2014
3
Faecal microbiota composition and host-microbe cross-talk following gastroenteritis and in postinfectious irritable bowel syndrome. (24310267)
2013
4
Intestinal amebiasis: a concerning cause of acute gastroenteritis among hospitalized lebanese children. (24404551)
2013
5
Neonatal eosinophilic gastroenteritis: possible in utero sensitization to cow's milk protein. (23985469)
2013
6
Genome sequence of a novel virus of the species human adenovirus d associated with acute gastroenteritis. (23405334)
2013
7
Multilevel analysis of childhood nonviral gastroenteritis associated with environmental risk factors in Quebec, 1999-2006. (24288849)
2013
8
High similarity of novel orthoreovirus detected in a child hospitalized with acute gastroenteritis to mammalian orthoreoviruses found in bats in Europe. (24025904)
2013
9
Canine parvovirus type 2c identified from an outbreak of severe gastroenteritis in a litter in Sweden. (24016358)
2013
10
Comment on "Viral acute gastroenteritis: clinical and epidemiological features of co-infected patients". (23332443)
2013
11
Prevalence of 10 human polyomaviruses in fecal samples from children with acute gastroenteritis: a case-control study. (23824769)
2013
12
Management strategies in the treatment of neonatal and pediatric gastroenteritis. (24194646)
2013
13
The effects of montelukast on eosinophilic gastroenteritis in a mouse model. (23240855)
2013
14
Delayed eosinophilic gastroenteritis, a possible side effect of clopidogrel? (23219131)
2013
15
Effectiveness of rotavirus vaccine in preventing severe acute gastroenteritis in children. (22423021)
2012
16
Antiviral activity of zinc salts against transmissible gastroenteritis virus in vitro. (22818659)
2012
17
Astrovirus gastroenteritis in hospitalized children of less than 5 years of age in Taiwan, 2009. (22209687)
2012
18
Risk factors for salmonella gastroenteritis in children less than five years of age in Taiwan. (22935864)
2012
19
An outbreak of Salmonella Typhimurium phage type 135a gastroenteritis linked to eggs served at an Australian Capital Territory cafAc. (23186240)
2012
20
Gastroenteritis outbreak associated with faecal shedding of canine norovirus in a Portuguese kennel following introduction of imported dogs from Russia. (22151979)
2012
21
Acute gastroenteritis. (23118314)
2012
22
Prevalence of severe acute rotavirus gastroenteritis and intussusceptions in Ghanaian children under 5 years of age. (22337844)
2012
23
Efficacy of a pentavalent human-bovine reassortant rotavirus vaccine against rotavirus gastroenteritis among American Indian children. (22252206)
2012
24
Gastric ulcer and gastroenteritis caused by Epstein-Barr virus during immunosuppressive therapy for a child with systemic juvenile idiopathic arthritis. (22589331)
2012
25
Eosinophilic gastroenteritis: a rare case report. (22912948)
2012
26
Antiemetic treatment for acute gastroenteritis in children: an updated Cochrane systematic review with meta-analysis and mixed treatment comparison in a Bayesian framework. (22815462)
2012
27
Gastroenteritis in children: treating dehydration. (22962884)
2012
28
Genetic characterization of sapovirus detected in hospitalized children with acute gastroenteritis in Korea. (23289192)
2012
29
Increased prevalence of rotavirus among children associated gastroenteritis in Riyadh Saudi Arabia. (22176997)
2011
30
Resolution of eosinophilic gastroenteritis after resection of uterine leiomyomas. (22009412)
2011
31
Travel-associated salmonella and campylobacter gastroenteritis in England: estimation of under-ascertainment through national laboratory surveillance. (22017719)
2011
32
Reactive arthritis in a population exposed to an extensive waterborne gastroenteritis outbreak after sewage contamination in Pirkanmaa, Finland. (21679096)
2011
33
Molecular techniques in ecohealth research toolkit: facilitating estimation of aggregate gastroenteritis burden in an irrigated periurban landscape. (22146856)
2011
34
A shift in the clinical spectrum of eosinophilic gastroenteritis toward the mucosal disease type. (20451664)
2010
35
Food allergy and eosinophilic gastroenteritis and colitis. (20431371)
2010
36
Central diabetes insipidus misdiagnosed as acute gastroenteritis in a pediatric patient. (18826743)
2008
37
Tumor necrosis factor-alpha and interleukin-10 in viral and bacterial gastroenteritis in children. (15984817)
2005
38
Eosinophilic gastroenteritis: epidemiology, diagnosis and management. (12175271)
2002
39
Eosinophilic gastroenteritis in children-report of one case. (11826918)
2001
40
Amplified fragment length polymorphism analysis of Campylobacter jejuni strains isolated from chickens and from patients with gastroenteritis or Guillain-BarrAc or Miller Fisher syndrome. (10966409)
2000
41
Interleukin 3, granulocyte-macrophage colony-stimulating factor, and interleukin 5 in eosinophilic gastroenteritis. (8608886)
1996
42
Eosinophilic gastroenteritis manifesting with ascites. (8091267)
1994
43
Oral administration of cromolyn in a patient with protein-losing enteropathy, food allergy, and eosinophilic gastroenteritis. (8170195)
1994
44
Eosinophilic gastroenteritis. (1770565)
1991
45
Eosinophilic gastroenteritis: a description of a new case with serous affectation. (3328515)
1987
46
Eosinophilic gastroenteritis. (6886944)
1983
47
Dysentery form gastroenteritis in infancy. (6275330)
1981
48
Eosinophilic gastroenteritis in extreme allergy. Immunopathological comparison with nonallergic gastrointestinal disease. (456850)
1979
49
Eosinophilic gastroenteritis. (4231978)
1967
50
Eosinophilic gastroenteritis. Two cases with incidental hiatus hernia. (6046691)
1967

Variations for Gastroenteritis

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Expression for genes affiliated with Gastroenteritis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gastroenteritis

Search GEO for disease gene expression data for Gastroenteritis.

Pathways for genes affiliated with Gastroenteritis

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Sources:
51PathCards, 39NCBI BioSystems Database, 13EMD Millipore, 56Reactome, 31KEGG
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Pathways related to Gastroenteritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IL5, CCL11
29.8IL5, CCL11
3
Show member pathways
9.5ALB, HGF
49.3IL5, ANPEP

Compounds for genes affiliated with Gastroenteritis

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Sources:
46Novoseek, 30IUPHAR, 25HMDB, 12DrugBank, 62Tocris Bioscience, 52PharmGKB, 3BitterDB
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Compounds related to Gastroenteritis according to GeneCards/GeneDecks:

(show top 50)    (show all 113)
idCompoundScoreTop Affiliating Genes
1unicap4610.1CCL11, IL5
2sodium cromoglycate4610.0IL5, CCL11
3lte44610.0CCL11, IL5
45-oxoete4610.0IL5, CCL11
5cetirizine46 30 25 1212.9CCL11, IL5
6roxithromycin46 30 1211.9IL5, CCL11
7optison469.9ALB, HGF
8ovomucoid469.9IL5, CSN1S1
9hepaplastin469.8ALB, HGF
10tween 80469.8ALB, CSN1S1
11icodextrin46 1210.8ALB, CSN1S1
12allergens469.6CCL11, CSN1S1, IL5
13ceftriaxone46 1210.6IL5, ALB
14dextran sulfate469.6IL5, HGF, ALB
15herbimycin a46 6210.5IL5, HGF, CCL11
16isotretinoin46 1210.5BTD, CSN1S1, HGF
17diclofenac46 30 52 1212.5CSN1S1, ALB, IL5
18polyacrylic acid469.5ANPEP, CSN1S1
19salicylic acid46 3010.5ALB, CSN1S1, IL5
20pranlukast46 30 1211.5IL5, CCL11
21sodium nitroprusside469.5HGF, CSN1S1, IL5
22hyaluronic acid46 2510.3CCL11, ALB, HGF
23imatinib46 52 1211.2IL5, HGF, ALB
24tacrolimus46 52 1211.2ALB, IL5, CCL11, HGF
25indomethacin46 30 62 1212.2IL5, CCL11, ALB, HGF
26sb 20358046 6210.2CSN1S1, IL5, CCL11, HGF
27lactose46 1210.2CSN1S1, IL5, ANPEP
28ly294002469.2CSN1S1, HGF, IL5, CCL11
29genistein46 30 62 3 25 1214.2CCL11, CSN1S1, HGF, IL5
30hydrocortisone46 3 62 1212.1IL5, ANPEP, HGF
31morphine46 52 30 1212.1IL5, ANPEP, CSN1S1
32vitamin d469.0CSN1S1, HGF, ALB, IL5
33polyethylene glycol469.0CSN1S1, ALB, ANPEP
34folate468.9HGF, CSN1S1, ALB
35testosterone46 62 25 1211.7ALB, HGF, CSN1S1, IL5
36matrigel468.7HGF, ANPEP, CCL11, CSN1S1
37prednisolone46 30 1210.7CCL11, ALB, CSN1S1, HGF, IL5
38histamine46 30 2510.7IL5, CSN1S1, CCL11, ALB, HGF
39thyroxine46 259.7ANPEP, IL5, CSN1S1, ALB
40aspartate468.5ALB, HGF, CSN1S1, ANPEP
41pge2468.4HGF, ANPEP, CCL11, IL5, CSN1S1
42arginine468.3HGF, CSN1S1, IL5, ANPEP, BTD
43retinoic acid46 259.3CSN1S1, CCL11, IL5, HGF, ANPEP
44cysteine468.2BTD, ANPEP, IL5, CSN1S1, ALB
45lactate468.2HGF, ANPEP, BTD, CSN1S1, ALB
46tyrosine468.0BTD, ANPEP, CCL11, IL5, HGF, CSN1S1
47serine467.9CSN1S1, HGF, IL5, ANPEP, BTD
48heparin46 30 25 1210.9ANPEP, CCL11, IL5, HGF, CSN1S1, ALB
49alanine467.8HGF, BTD, ALB, CSN1S1, CCL11, ANPEP
50calcium46 52 25 1210.5SCN1B, CCL11, ALB, CSN1S1, HGF, ANPEP

GO Terms for genes affiliated with Gastroenteritis

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Sources:
17Gene Ontology
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Cellular components related to Gastroenteritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.5ALB, HGF
2extracellular spaceGO:0056158.1CCL11, IL5, HGF, ALB, BTD
3extracellular regionGO:0055767.1BTD, ALB, CSN1S1, HGF, IL5, CCL11

Biological processes related to Gastroenteritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet degranulationGO:0025769.5ALB, HGF
2positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.4HGF, IL5

Products for genes affiliated with Gastroenteritis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gastroenteritis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet