Gastroenteritis malady

MedlinePlus: Have you ever had the "stomach flu?" what you probably had was gastroenteritis - not a type of flu at all. gastroenteritis is an inflammation of the lining of the intestines caused by a virus, bacteria or parasites. viral gastroenteritis is the second most common illness in the u.s. it spreads through contaminated food or water, and contact with an infected person. the best prevention is frequent hand washing. symptoms of gastroenteritis include diarrhea, abdominal pain, vomiting, headache, fever and chills. most people recover with no treatment. the most common problem with gastroenteritis is dehydration. this happens if you do not drink enough fluids to replace what you lose through vomiting and diarrhea. dehydration is most common in babies, young children, the elderly and people with weak immune systems. nih: national institute of diabetes and digestive and kidney diseases²³

MalaCards: Gastroenteritis, also known as cholera morbus, is related to eosinophilic gastroenteritis and food allergy. An important gene associated with Gastroenteritis is NOV (nephroblastoma overexpressed), and among its related pathways are Asthma and Immune System. The drugs erythromycin and erythromycin ethylsuccinate and the compounds endotoxin and ivig have been mentioned in the context of this disorder. Affiliated tissues include small intestine, kidney and pancreas, and related mouse phenotypes are hematopoietic system and endocrine/exocrine gland.

Disease Ontology: A gastrointestinal system infectious disease that involves inflammation of the lining of the stomach and small and large intestines, which is caused by viruses, bacteria, or parasites. chemicals and drugs also cause gastroenteritis. the symptoms include diarrhea, loss of appetite, nausea, vomiting, cramps, and discomfort in the abdomen.⁶

Wikipedia: Gastroenteritis is a medical condition characterized by inflammation (\"-itis\") of the gastrointestinal...⁴⁴ more...

Aliases & Descriptions:

gastroenteritis 6 8 32 23 43 cholera morbus 6 43

infectious colitis, enteritis and gastroenteritis 6 infectious colitis 43

Diseases related to gastroenteritis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 668)

id	Related Disease	Score	Top Affiliating Genes
1	eosinophilic gastroenteritis	34.6	IL5, CCL11, IGES, IGHE, ALB, SRF
2	food allergy	28.7	IL5, CCL11, IGES, IGHE, RNASE3, CSN1S1
3	convulsions	27.4	SCN1B, SCN1A, IL1B, IL6, CAT, DBH
4	shigellosis	27.0	VDAC1, CD79A, CD248, IL1B, IL8, SUMF2
5	hypereosinophilic syndrome	26.6	IL2, IL5, CCL11, IGES, IGHE, IFNA1
6	cramps	26.5	REN, LACTB, IL10, IL1B, IFNA1, ALB
7	ulcerative colitis	25.7	CD79A, MLN, GUSB, IL10, IL12RB1, IL1B
8	crohn's disease	25.1	MLN, IL10, IL1B, IL1RN, IL23A, IL6
9	eosinophilia	24.9	REN, CD79A, IL10, IL1B, IL2, IL5
10	cholera	23.2	VDAC1, CD79A, IL10, IL1B, IL2, IL5
11	celiac disease	22.8	LCT, CD79A, MLN, IL10, IL1B, IL1RN
12	influenza	22.7	VDAC1, LACTB, CD79A, IL10, IL1B, IL1RN
13	noonan syndrome	21.4	REN, SGCG, VDAC1, IL10, IL1RN, IL2
14	atherosclerosis	21.0	REN, LCT, CD79A, FLT4, FIGF, IL10
15	peritonitis	18.8	REN, USF2, CLDN3, LACTB, CD79A, CDH1
16	pancreatitis	16.9	REN, VEGFC, VDAC1, USF2, CLDN3, FUT2
17	nocardiosis	14.0	LACTB, IL12RB1, IGHE, LRWD1, CSN1S1
18	strongyloidiasis	14.0	CD79A, IL5, CCL11, IGHE, ALB
19	allergic bronchopulmonary aspergillosis	14.0	IL5, IGES, IGHE
20	echinococcosis	13.9	CD79A, IL10, IL5, MDH2, IGHE
21	pthirus pubis infestation	13.9	IL5, CCL11, IGHE
22	b cell deficiency	13.8	CD79A, IL5, IGHE
23	vulvovaginitis	13.8	CD79A, IL10, IL5, IGHE
24	eosinophilic pneumonia	13.8	IL5, CCL11, IGHE, RNASE3
25	vernal keratoconjunctivitis	13.8	IL5, CCL11, IGES, IGHE, RNASE3, PRG2
26	intrinsic asthma	13.8	IL5, IGES, IGHE, RNASE3
27	eosinophilic esophagitis	13.8	IL10, IL5, CCL11, IGES, IGHE, RNASE3
28	chronic eosinophilic pneumonia	13.8	IL5, CCL11, RNASE3
29	allergic rhinitis	13.8	IL5, IGES, IGHE, RNASE3
30	asthma	13.8	IL5, IGES, IGHE, RNASE3
31	bullous pemphigoid	13.8	CD79A, IL5, CCL11, IGHE, RNASE3, PRG2
32	cough variant asthma	13.8	IL10, IL5, IGHE, RNASE3
33	giant papillary conjunctivitis	13.8	IL5, CCL11, RNASE3
34	helminthiasis	13.8	IL5, IGHE, RNASE3
35	dental caries	13.8	CD79A, ALB, CRP, LRWD1, CSN1S1
36	urinary schistosomiasis	13.8	IL10, IL5, IGHE, RNASE3
37	dermatitis herpetiformis	13.8	CD79A, IL5, CCL11, TGM3, GAST
38	ocular cicatricial pemphigoid	13.7	CD79A, IL5, RNASE3, PRG2
39	hyper-ige syndrome	13.7	CD79A, IGES, IGHE
40	acalculous cholecystitis	13.7	GUSB, CCK, TDH
41	dysphagia	13.7	SALL1, IL5, ALB, CP
42	onchocerciasis	13.7	IL10, IL5, CCL11, IGHE, PHB2, RNASE3
43	miliary tuberculosis	13.7	IL10, IGHE, ALB
44	iron metabolism disease	13.6	CRP, CSN1S1, SLC11A1, CP
45	bacteremia, protection against	13.6	LACTB, GUSB, CAT, CRP
46	syphilis	13.6	LACTB, CD79A, IGHE, NLRP12, CP
47	gallbladder disease	13.6	IL10, CCK, ALB, CRP
48	lactose intolerance	13.6	LCT, CD79A, CSN1S1
49	omenn syndrome	13.6	IL10, IL1RN, IL5, IGHE
50	respiratory failure	13.5	LACTB, CCL11, IGES, IGHE, CAT, RNASE3

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 erythromycin, erythromycin estolate, erythromycin ethylsuccinate, erythromycin gluceptate, erythromycin lactobionate, erythromycin pwdr [va product], erythromycin stearate

MalaCards organs/tissues related to gastroenteritis:

²²

MGI Mouse Phenotypes related to gastroenteritis:

²⁵ (show all 15)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	9.7	PDGFB, TLR5, TLR9, PRG2, SLC11A1, PER1
2	endocrine/exocrine gland phenotype	MP:0005379	9.2	GAL, CSN3, DBH, PHB2, PPT2, TRH
3	digestive/alimentary phenotype	MP:0005381	9.1	NLRP12, TFF3, SOS1, SLC11A1, CPE, GAST
4	no phenotypic analysis	MP:0003012	9.1	GHRL, SRF, SPI1, PDGFB, SOS1, CASP6
5	normal phenotype	MP:0002873	8.6	CCL11, ALB, GHRL, PYY, SRF, ODC1
6	immune system phenotype	MP:0005387	8.3	SPI1, PPT2, NOV, NLRP12, SLC11A1, LYVE1
7	nervous system phenotype	MP:0003631	8.2	PYY, SPI1, PPT2, COLQ, ST8SIA2, DBH
8	tumorigenesis	MP:0002006	7.5	IL6, CAT, SPI1, NLRP12, SLC11A1, IL5
9	reproductive system phenotype	MP:0005389	7.2	ANPEP, PHB2, PDGFB, CSN1S1, CSN3, CPE
10	behavior/neurological phenotype	MP:0005386	6.4	COLQ, NOV, PPT2, SRF, PYY, GHRL
11	growth/size phenotype	MP:0005378	6.1	PDGFB, PHB2, COLQ, NOV, SPI1, SRF
12	cellular phenotype	MP:0005384	6.1	TLR5, PHB2, NLRP12, NOV, PPT2, SPI1
13	mortality/aging	MP:0010768	5.9	PHB2, COLQ, NOV, PPT2, SPI1, ODC1
14	cardiovascular system phenotype	MP:0005385	5.7	PDGFB, NOV, CRP, SRF, TLR5, DBH
15	homeostasis/metabolism phenotype	MP:0005376	5.4	GAST, PDGFB, NLRP12, NOV, CRP, SPI1

Articles related to gastroenteritis:

(show all 46)

id	Title	Authors	Year	Affiliating Genes
1	SCN1B is not related to benign partial epilepsy in in fancy or convulsions with gastroenteritis. (21882141)	Yamashita S.... Shimizu T.	2011	SCN1B
2	The IL-23 axis in Salmonella gastroenteritis. (21740501)	Godinez I.... BAoumler A.J.	2011	IL23A
3	Benign convulsions with mild gastroenteritis: is it a ssociated with sodium channel gene SCN1A mutation? (20519669)	Weng W.C.... Lee W.T.	2010	SCN1A
4	Genetic risk factors for post-infectious irritable bo wel syndrome following a waterborne outbreak of gastroenteritis. (20044998)	Villani A.C.... Marshall J.K.	2010	CDH1, IL6, TLR9
5	Two cases of Noonan syndrome with severe respiratory and gastroenteral involvement and the SOS1 mutation F623I. (20673819)	Fabretto A.... Zenker M.	2010	SOS1
6	Pathogenic mechanisms of postinfectious functional ga strointestinal disorders: results 3 years after gastroenteritis. (19711225)	Mearin F.... Coderch J.	2009	IL6, IL1B, IL10
7	Altered antioxidant status and increased lipid peroxidation in children with acute gastroenteritis admitted to a pediatric emergency service. (18164165)	BayiroA9lu F.... Dede S.	2009	CAT, ALB, CP
8	Quantitative analysis of lymphangiogenic markers in human gastroenteric tumor. (17174733)	Yuanming L.... Ying W.	2007	FLT4, VEGFC, FIGF
9	The effects of enteral nutrition vs parenteral nutrition on gastric motility and gastroenteric hormones after subtotal gastrectomy: a perspective randomized compared clinical trial (16836917)	Zhang Q.... Qian J.M.	2006	CCK, GAST
10	Serotype distribution and antimicrobial resistance of Salmonella enterica from patients with gastroenteritis in Crete, Greece. (16498523)	Maraki S.... Tselentis Y.	2006	LACTB
11	Tumor necrosis factor-alpha and interleukin-10 in viral and bacterial gastroenteritis in children. (15984817)	Hsu T.R.... Tang R.B.	2005	CRP, IL10
12	Early enteral nutrition in young dogs suffering from haemorrhagic gastroenteritis. (16109106)	Will K.... Zentek J.	2005	GLUD1
13	Ghrelin in gastroenteric pathophysiology. (16370568)	Locatelli V.... Netti C.	2005	GHRL, CPOX
14	Nosocomial outbreak of pediatric gastroenteritis caused by CTX-M-14-type extended-spectrum beta-lactamase-producing strains of Salmonella enterica serovar London. (16000495)	Yong D.... Chong Y.	2005	LACTB
15	Eosinophilic gastroenteritis. (15833687)	Khan S.	2005	CCL11
16	Rebound eosinophilia after treatment of hypereosinophilic syndrome and eosinophilic gastroenteritis with monoclonal anti-IL-5 antibody SCH55700. (15577851)	Kim Y.J.... Klion A.D.	2004	IL5, SRF
17	A case of eosinophilic gastroenteritis: observation of serum IL-5 and sIL-2R levels before and after remission (15187490)	To M.... Sano Y.	2004	IL5
18	Bone mineral changes in acute metabolic acidosis due to acute gastroenteritis. (15592794)	Yildizdas D.... Ozer G.	2004	CALCA
19	Allergic eosinophilic gastroenteritis in a child with Crohn's disease. (15301307)	Tella R.... Batlle X.	2004	IGHE
20	High hepatocyte growth factor levels in faeces during acute infectious gastroenteritis. (14723362)	Nayeri F.... Forsberg P.	2003	HGF
21	Pseudohypoaldosteronism presenting as acute gastroenteritis: report of one case. (12800385)	Yu M.C.... Hou J.W.	2003	REN
22	Oral disodium cromoglycate and ketotifen for a patient with eosinophilic gastroenteritis, food allergy and protein-losing enteropathy. (15032404)	Suzuki J.... Suzuki H.	2003	ALB
23	Effect of metabolic disorders accompanying gastroenteritis on the pancreatic exocrine function in piglets. C. Histopathological and immunohistochemical changes in the pancreas of piglets with gastroenteritis. (12448081)	Rychlik A.	2002	DBH, GAL
24	New gastroenteric hormone: ghrelin and its potential development of atherosclerosis (12687937)	Kempa A.... Krzyzanowska-Swiniarska B.	2002	GHRL
25	A study of serum mitochondrial enzymes(mCK, mAST, mMDH) in rotavirus and adenovirus gastroenteritis in pediatric patients (11769565)	Hoshino T.... Kawano K.	2001	MDH2
26	The viral nucleocapsid protein of transmissible gastroenteritis coronavirus (TGEV) is cleaved by caspase-6 and -7 during TGEV-induced apoptosis. (10756009)	Eleouet J.F.... Martin S.J.	2000	CASP6
27	Inflammatory and immunological parameters in children with haemolytic uremic syndrome (HUS) and gastroenteritis-pathophysiological and diagnostic clues. (10843773)	Westerholt S.... Oberhoffer R.	2000	IL8, IL10
28	Allergic reaction to gemfibrozil manifesting as eosin ophilic gastroenteritis. (10963515)	Lee J.Y.... Tumpkin C.	2000	IGHE
29	RT-PCR analysis of immune-modulating factors in PBMCs from patients with cancer: reduced IL-2 and increased IL-2-receptor (p55) expression characterize gastroenteric neoplasms. (10368673)	Piancatelli D.... Casciani C.U.	1999	IL2
30	Eosinophilic gastroenteritis presenting with acute pa ncreatitis. (9355030)	Maeshima A.... Naruse T.	1997	IL5
31	Gastric acid, acid-suppressing drugs, and bacterial gastroenteritis: how much of a risk? (9270961)	Garcia RodrA-guez L.A.... RuigA^mez A.	1997	HRH2
32	Interspecies aminopeptidase-N chimeras reveal species-specific receptor recognition by canine coronavirus, feline infectious peritonitis virus, and transmissible gastroenteritis virus. (8985407)	Benbacer L.... Delmas B.	1997	ANPEP
33	Cases of gastroenteritis associated to Vibrio cholerae no 01 in Oran, Salta (9102658)	Rivas M.... Caffer M.I.	1996	ODC1
34	Interleukin 3, granulocyte-macrophage colony-stimulating factor, and interleukin 5 in eosinophilic gastroenteritis. (8608886)	Desreumaux P.... Janin A.	1996	IL5
35	Antiviral action of interferon-alpha against porcine transmissible gastroenteritis virus. (7653029)	Jordan L.T.... Derbyshire J.B.	1995	IFNA2, IFNA1
36	Eosinophilic gastroenteritis presenting as protein--losing enteropathy (case report). (7732607)	Karademir S.... Ural C.	1995	IGES
37	Evidence for an abnormal profile of interleukin-4 (IL-4), IL-5, and gamma-interferon (gamma-IFN) in peripheral blood T cells from patients with allergic eosinophilic gastroenteritis. (7814459)	Jaffe J.S.... Metcalfe D.D.	1994	IL5, IGHE
38	Localized eosinophilic gastroenteritis with necrotizi ng granulomas presenting as acute abdomen. (7937432)	Fraile G.... Redondo C.	1994	IGHE
39	Determinants essential for the transmissible gastroenteritis virus-receptor interaction reside within a domain of aminopeptidase-N that is distinct from the enzymatic site. (7913510)	Delmas B.... Laude H.	1994	ANPEP
40	Oral bacteriotherapy for viral gastroenteritis. (7995184)	Isolauri E.... Salminen S.	1994	GUSB
41	IgE antibodies against bovine serum albumin in a case of eosinophilic gastroenteritis. (8238812)	Verdaguer J.... Buendia E.	1993	IGHE
42	Sequence determination of the nucleocapsid protein gene of the porcine epidemic diarrhoea virus confirms that this virus is a coronavirus related to human coronavirus 229E and porcine transmissible gastroenteritis virus. (8397280)	Bridgen A.... Ackermann M.	1993	NLRP12
43	Gut regulatory peptides and intestinal permeability in acute infantile gastroenteritis. (1575547)	Lawson G.R.... Aynsley-Green A.	1992	PYY, MLN
44	Interleukin-5 in eosinophilic gastroenteritis. (1380204)	Takahashi T.... Imura H.	1992	IL5
45	Deposition of eosinophil granule major basic protein in eosinophilic gastroenteritis and celiac disease. (1612323)	Talley N.J.... Gleich G.J.	1992	PRG2
46	Gastroenteritis with eosinophilia caused by Giardia lamblia (2244060)	Ortiz Arduan A.... JimAcnez Casado M.	1990	IGHE

Genes related to gastroenteritis according to GeneCards:

(show top 50)    (show all 110)

id	Symbol	Description	Score	GeneCards Section Context
1	NOV	nephroblastoma overexpressed	11.0
2	PRB3	proline-rich protein BstNI subfamily 3	11.0
3	CCL11	chemokine (C-C motif) ligand 11	11.0	Publications
4	ANPEP	alanyl (membrane) aminopeptidase	11.0	Publications
5	IL5	interleukin 5 (colony-stimulating factor, eosinophil)	11.0	Publications
6	CSN1S1	casein alpha s1	11.0
7	IGHE	immunoglobulin heavy constant epsilon	11.0	Publications
8	RPS19BP1	ribosomal protein S19 binding protein 1	11.0
9	C6orf47	chromosome 6 open reading frame 47	11.0
10	PCOLCE	procollagen C-endopeptidase enhancer	11.0
11	CD248	CD248 molecule, endosialin	11.0
12	SEMG1	semenogelin I	11.0
13	SIVA1	SIVA1, apoptosis-inducing factor	11.0
14	PPAP2C	phosphatidic acid phosphatase type 2C	11.0
15	IGES	immunoglobulin E concentration, serum	11.0	Publications
16	EPYC	epiphycan	11.0
17	ICT1	immature colon carcinoma transcript 1	11.0
18	PRG2	proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)	11.0	Publications
19	ZNF77	zinc finger protein 77	11.0
20	LPAL2	lipoprotein, Lp(a)-like 2, pseudogene	11.0
21	KIR2DL4	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4	11.0
22	GALE	UDP-galactose-4-epimerase	11.0
23	SALL1	sal-like 1 (Drosophila)	11.0
24	ZNF185	zinc finger protein 185 (LIM domain)	11.0
25	IL23A	interleukin 23, alpha subunit p19	11.0	Publications
26	TDH	L-threonine dehydrogenase	11.0
27	TGM3	transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)	11.0
28	TMEM48	transmembrane protein 48	11.0
29	MDH2	malate dehydrogenase 2, NAD (mitochondrial)	11.0	Publications
30	SYNRG	synergin, gamma	11.0
31	IL17RD	interleukin 17 receptor D	11.0
32	LRWD1	leucine-rich repeats and WD repeat domain containing 1	11.0
33	HRH2	histamine receptor H2	11.0	Publications
34	SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	11.0
35	SPI1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	11.0
36	TLR5	toll-like receptor 5	11.0
37	SRF	serum response factor (c-fos serum response element-binding transcription factor)	11.0	Publications
38	IL12RB1	interleukin 12 receptor, beta 1	11.0
39	ADAR	adenosine deaminase, RNA-specific	11.0
40	EMCN	endomucin	11.0
41	CLPB	ClpB caseinolytic peptidase B homolog (E. coli)	11.0
42	GUSB	glucuronidase, beta	11.0	Publications
43	CPE	carboxypeptidase E	11.0
44	VDAC1	voltage-dependent anion channel 1	11.0
45	BTD	biotinidase	11.0
46	LACTB	lactamase, beta	11.0	Publications
47	HGF	hepatocyte growth factor (hepapoietin A; scatter factor)	11.0	Publications
48	CD79A	CD79a molecule, immunoglobulin-associated alpha	11.0
49	IL10	interleukin 10	11.0	Publications
50	ALB	albumin	11.0	Publications

Pathways related to gastroenteritis according to GeneDecks:

(show top 50)    (show all 65)

id	Pathway	Score	Top Affiliating Genes
1	Asthma20	10.5	PRG2, RNASE3, CCL11, IL5, IL10
2	Immune System38	10.4	HGF, ADAR, TLR5, IL5, CDH1, CD79A
3	NFAT Signaling and Lymphocyte Interactions36	10.3	CCL11, IL5, IL23A, IL2
4	RAR-Gamma-RXR-Alpha Degradation36	10.3	IL2, IL23A, CCL11
5	Th1 Differentiation37	9.9	IL10, IL12RB1, IL2, TLR5, TLR9
6	Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response10	9.8	TLR5, CCL11, IL6
7	Th17 Differentiation37	9.3	TLR9, TLR5, IL6, IL23A, IL1B, IL12RB1
8	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.3	TLR9, TLR5, IL6, IL23A, IL1B
9	PGC1Alpha Pathway36	9.2	CCL11, IL8, IL5, IL23A, IL2, IL1B
10	Jak-STAT signaling pathway20	9.2	SOS1, IFNA2, IFNA1, IL5, IL23A, IL2
11	IP3 Pathway36	9.2	VEGFC, CD79A, FLT4, FIGF, IL2, PDGFB
12	Regulation of eIF4 and p70S6K36	9.0	SOS1, CCL11, IL6, IL5, IL23A, IL2
13	Immune response_TLR signaling pathways41	9.0	TLR9, TLR5, CCL11, IL8, IL6
14	Malaria20	8.7	HGF, TLR9, IL8, IL6, IL1B, IL10
15	Akt Signaling36	8.6	HGF, PDGFB, CCL11, IL6, IL23A, IL2
16	Endothelin-1 Signaling Pathway36	8.6	SOS1, CASP6, IL6, IL5, IL23A, IL2
17	p53 Mediated Apoptosis36	8.5	HGF, PDGFB, CASP6, IL6, IL2, FIGF
18	Mitochondrial Apoptosis36	8.5	HGF, PDGFB, IL6, IL2, FIGF, FLT4
19	Molecular Mechanisms of Cancer36	8.5	CASP6, PDGFB, PRG2, SOS1, HGF, CCL11
20	MIF Mediated Glucocorticoid Regulation36	8.4	HGF, CCL11, IL8, IL6, IL5, IL23A
21	MIF Regulation of Innate Immune Cells36	8.4	HGF, CCL11, IL8, IL6, IL5, IL23A
22	PEDF Induced Signaling36	8.4	HGF, SRF, CCL11, IL8, IL6, IL5
23	all-trans-Retinoic Acid Signaling in Brain36	8.4	HGF, CCL11, IL8, IL6, IL5, IL23A
24	Cellular Apoptosis Pathway36	8.3	HGF, PDGFB, IL6, IL2, FIGF, FLT4
25	STAT3 Pathway36	8.3	HGF, CCL11, IL8, IL6, IL5, IL23A
26	IL-6 Pathway36	8.3	HGF, CCL11, IL8, IL6, IL5, IL23A
27	p70S6K Signaling36	8.3	HGF, SOS1, HBG1, PDGFB, IL6, IL2
28	Rho Family GTPases36	8.2	IL8, CCL11, PDGFB, PRG2, HGF, IL23A
29	eIF2 Pathway36	8.1	SOS1, PDGFB, IL6, IL2, FIGF, FLT4
30	DHA Signaling36	8.1	HGF, PDGFB, CASP6, IL6, IL2, IL1B
31	NF-KappaB (p50-p65) Pathway36	8.1	HGF, TLR9, TLR5, PDGFB, IL6, IL2
32	NF-KappaB Family Pathway36	8.1	PDGFB, TLR5, TLR9, HGF, IL6, IL2
33	SOCS Pathway36	8.1	IL5, IL6, IL8, CCL11, IL23A, IL2
34	PPAR Pathway36	8.1	SOS1, PDGFB, IL6, IL2, FIGF, FLT4
35	Glucocorticoid Receptor Signaling36	8.1	CCL11, IL8, IL6, IL5, IL23A, IL2
36	Renin-Angiotensin Pathway36	8.1	HGF, SOS1, PDGFB, IL6, IL2, FIGF
37	Activation of cAMP-Dependent PKA36	8.1	SCN1A, FLT4, FIGF, IL2, IL6, CRP
38	ERK Signaling36	8.1	IL6, SRF, PDGFB, PRG2, SOS1, IL5
39	Apoptotic Pathways in Synovial Fibroblasts36	8.0	HGF, PDGFB, IL6, IL2, FIGF, FLT4
40	Toll-like receptor signaling pathway20	7.9	TLR9, TLR5, IFNA2, IFNA1, IL8, IL6
41	Measles20	7.8	ADAR, TLR9, IFNA2, IFNA1, IL6, IL2
42	Tec Kinases Signaling36	7.6	IL8, CCL11, PDGFB, TLR5, TLR9, HGF
43	Cytokine Network36	7.6	IFNA2, IFNA1, IL8, IL6, IL5, IL2
44	Antioxidant Action of Vitamin-C36	7.6	IL5, IL6, IL8, CCL11, PDGFB, HGF
45	PAK Pathway36	7.6	IL6, IL8, CCL11, CASP6, PDGFB, HGF
46	MAPK Family Pathway36	7.4	IL6, IL8, CCL11, PDGFB, SOS1, HGF
47	p38 Signaling36	7.3	IL6, IL8, CCL11, CASP6, PDGFB, SOS1
48	TGF-Beta Pathway36	7.2	IL6, IL8, CCL11, PDGFB, SOS1, HGF
49	Cytokine-cytokine receptor interaction20	6.8	VEGFC, HGF, PDGFB, IFNA2, IFNA1, CCL11
50	JAK-STAT Pathway36	6.6	IL8, CCL11, IFNA1, IFNA2, PDGFB, SOS1

Compounds related to gastroenteritis according to GeneDecks:

(show top 50)    (show all 273)

id	Compound	Score	Top Affiliating Genes
1	endotoxin32	10.3	CRP, HRH2, GHRL, SRF, TLR9, CCL11
2	ivig32	10.1	CRP
3	allergens32	10.1	IL10, IL1RN, IGES, CD79A, PRG2, CSN1S1
4	citrate32	10.0	VDAC1, CSN1S1, GLUD1, CAT, MDH2, GUSB
5	azithromycin32 9 9	11.8	CRP, SRF, IL10, MLN, CD79A, LACTB
6	salbutamol32 34 9 18 9	13.7	CCL11, GAL, RNASE3, CD79A, IL10, IL8
7	clarithromycin32 9 9	11.5	GAST, LACTB, CD79A, IL1RN, IL5, IL8
8	sb 20358032 42	10.3	IL6, CCL11, CRP, HGF, GAST, CDH1
9	aspirin32 34 18	11.1	CRP, HGF, GUSB, IGES, TFF3, CCL11
10	glucose32	9.1	VEGFC, BTD, CSN3, LCT, MDH2, GAST
11	mannitol32 9 9	11.1	GHRL, ODC1, CSN1S1, CP, CDH1, GLUD1
12	glutamate32	9.1	ODC1, GLUD1, SRF, GAL, VDAC1, CD79A
13	pge232	9.0	CCL11, CPOX, REN, CDH1, IL1RN, IL23A
14	oxygen32 18	10.0	GHRL, HRH2, GLUD1, CASP6, CCL11, ANPEP
15	isotretinoin32 9 9	11.0	ODC1, IFNA1, CSN1S1, HGF, IFNA2, BTD
16	methacholine32 9 9	11.0	IL8, IL5, CD79A, REN, IGHE, CALCA
17	creatinine32	8.9	CP, CSN1S1, CRP, SRF, REN, VDAC1
18	thyroxine32 18	9.8	REN, IFNA2, MLN, GAST, CP, CSN1S1
19	heparin32 9 18 9	11.8	GAST, HGF, MLN, IL1RN, ALB, SRF
20	arginine32	8.7	REN, KIR2DL4, BTD, NLRP12, RNASE3, PRG2
21	carbohydrates32	8.7	CDH1, PYY, ODC1, CSN1S1, FUT2, LCT
22	acetylcholine32 9 18 9	11.7	TRH, HRH2, GLUD1, CALCA, CD79A, MLN
23	epinephrine32 9 18 9	11.6	GAST, GAL, DBH, GHRL, HRH2, IGHE
24	methotrexate32 34 42 9 9	12.3	SRF, CDH1, IL6, IL1RN, IL5, CD79A
25	peptidoglycan32	8.3	IL6, TLR9, TLR5, CCL11, IL8, IL1RN
26	testosterone32 9 18 9	11.3	IL1RN, VEGFC, TRH, SRF, ODC1, NONO
27	bucillamine32	8.3	IL1B, CRP, IL6, CAT, CD79A, IL2
28	hydrogen32 18	9.2	TRH, DBH, RNASE3, SRF, PYY, GHRL
29	vitamin d32	7.9	CDH1, CD79A, GAST, HGF, CP, SLC11A1
30	prednisolone32 9 9	9.9	IL6, IL2, ALB, CCL11, IGHE, IFNA1
31	il-1232	7.8	IFNA1, IL8, IL6, IL5, IL2, IL1B
32	superoxide32 18	8.6	IL1RN, CP, CPOX, HGF, DBH, SRF
33	norepinephrine32 9 18 9	10.6	GAL, REN, HGF, CD79A, CALCA, DBH
34	estrogen32	7.5	FLT4, CDH1, VEGFC, GAST, LYVE1, CP
35	acth32	7.3	REN, MLN, GAL, IL1B, IL1RN, IL6
36	indomethacin32 9 9	9.3	HGF, CPOX, CP, PRG2, IFNA2, CCL11
37	vegf32	7.1	REN, RNASE3, PDGFB, TFF3, CP, LYVE1
38	neopterin32	7.0	IL6, IL1B, IL10, CD79A, IL8, IFNA1
39	alanine32	7.0	GHRL, CCL11, ANPEP, MDH2, IL1RN, MLN
40	hydrocortisone32 9 9	8.6	HGF, IL5, GAST, REN, IGHE, LCT
41	thymidine32 18	7.6	IL10, TRH, PYY, ODC1, PDGFB, LYVE1
42	cyclosporin a32 42	7.4	HGF, IL6, PDGFB, RNASE3, IL5, IL2
43	lactate32	6.4	HGF, CPOX, CP, CSN1S1, DBH, RNASE3
44	lipid32	6.4	IFNA2, PYY, GAL, SRF, CRP, RNASE3
45	cycloheximide32	6.2	IGHE, ANPEP, IL6, IL10, IL1RN, IL2
46	serine32	6.0	IL2, IL1RN, BTD, MLN, CDH1, IL5
47	nitric oxide32 9 18 9	8.4	PRG2, SLC11A1, CPOX, GAL, DBH, REN
48	histamine32 18	6.3	CD79A, CCK, IGES, IGHE, IFNA2, ALB
49	tyrosine32	4.9	SPI1, IL6, VDAC1, CCK, IFNA1, IFNA2
50	dexamethasone32 42 34 9 9	8.4	RNASE3, SRF, TRH, GHRL, GLUD1, IFNA1

Cellular components related to gastroenteritis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	platelet alpha granule lumen	GO:031093	9.8	VEGFC, FIGF, ALB, PDGFB, HGF
2	secretory granule	GO:030141	9.0	GAL, CPE, DBH, TFF3, TRH, GHRL
3	extracellular space	GO:005615	5.2	CCL11, CCK, IFNA2, ALB, CALCA, GHRL
4	extracellular region	GO:005576	4.2	GAST, CRP, NOV, RNASE3, PDGFB, TLR9

Biological processes related to gastroenteritis according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of T-helper 1 type immune response	GO:002827	10.5	IL12RB1, IL23A, SLC11A1
2	negative regulation of glutamate secretion	GO:014050	9.8	TRH, IL1RN, IL1B
3	positive regulation of interferon-gamma production	GO:032729	9.7	SLC11A1, IL23A, IL2, IL1B, IL12RB1
4	positive regulation of interleukin-8 production	GO:032757	9.7	TLR9, TLR5, CALCA, IL1B
5	response to molecule of bacterial origin	GO:002237	9.7	IL10, IL8, TLR9
6	vasculature development	GO:001944	9.5	SPI1, CALCA, FLT4
7	positive regulation of cell division	GO:051781	9.3	VEGFC, FIGF, IL1B, CAT, PDGFB
8	positive regulation of immunoglobulin secretion	GO:051024	9.3	IL6, IL5, IL2
9	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.3	HGF, PDGFB, CCK, IL6, IL5
10	response to hypoxia	GO:001666	9.0	PDGFB, PLOD2, CRP, SRF, TRH, CAT
11	positive regulation of interleukin-6 production	GO:032755	9.0	FIGF, IL1B, IL6, TLR9
12	platelet activation	GO:030168	9.0	HGF, SOS1, PDGFB, SRF, ALB, IL6
13	cell-cell signaling	GO:007267	8.2	PYY, TRH, CALCA, IFNA2, IL2, IL1B
14	inflammatory response	GO:006954	7.7	IL10, GAL, SLC11A1, TLR9, TLR5, CRP

Molecular functions related to gastroenteritis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	neuropeptide hormone activity	GO:005184	9.6	CCK, TRH, PYY, GAL
2	interleukin-1 receptor binding	GO:005149	9.4	TLR9, TLR5, IL1RN, IL1B
3	cytokine activity	GO:005125	8.3	IL6, IL5, IL23A, IL2, IL1B, IL10
4	growth factor activity	GO:008083	8.0	VEGFC, EPGN, HGF, PDGFB, NOV, IL6