MCID: GST045
MIFTS: 53

Gastroenteritis malady

Gastrointestinal diseases category

Summaries for Gastroenteritis

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Have you ever had the "stomach flu?" what you probably had was gastroenteritis - not a type of flu at all. gastroenteritis is an inflammation of the lining of the intestines caused by a virus, bacteria or parasites. viral gastroenteritis is the second most common illness in the u.s. the cause is often a norovirus infection. it spreads through contaminated food or water, and contact with an infected person. the best prevention is frequent hand washing. symptoms of gastroenteritis include diarrhea, abdominal pain, vomiting, headache, fever and chills. most people recover with no treatment. the most common problem with gastroenteritis is dehydration. this happens if you do not drink enough fluids to replace what you lose through vomiting and diarrhea. dehydration is most common in babies, young children, the elderly and people with weak immune systems. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Gastroenteritis, also known as cholera morbus, is related to eosinophilic gastroenteritis and pancreatitis. An important gene associated with Gastroenteritis is IL5 (interleukin 5 (colony-stimulating factor, eosinophil)), and among its related pathways are Allograft rejection and IL4-mediated signaling events. The drug erythromycin pwdr and the compounds histamine and prednisolone have been mentioned in the context of this disorder. Affiliated tissues include kidney, small intestine and testes.

Disease Ontology:8 A gastrointestinal system infectious disease that involves inflammation of the lining of the stomach and small and large intestines, which is caused by viruses, bacteria, or parasites. chemicals and drugs also cause gastroenteritis. the symptoms include diarrhea, loss of appetite, nausea, vomiting, cramps, and discomfort in the abdomen.

Wikipedia:63 Gastroenteritis or infectious diarrhea is a medical condition characterized by inflammation (\"-itis\")... more...

Aliases & Classifications for Gastroenteritis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

gastroenteritis 8 10 44 33 60
cholera morbus 8 60
infectious colitis, enteritis and gastroenteritis 8


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Disease Ontology8 DOID:2326
MeSH34 D005759
NCIt39 C34632

Related Diseases for Gastroenteritis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Gastroenteritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 227)
idRelated DiseaseScoreTop Affiliating Genes
1eosinophilic gastroenteritis31.6CCL11, CSN1S1, IGHE, IL5
2pancreatitis30.5ALB
3eosinophilic esophagitis30.4CCL11, IL5
4esophagitis30.4IL5, PRG2, CCL11
5eosinophilia30.4SRF, IL5, RNASE3, IGHE, PRG2, CCL11
6arthritis30.4ALB, LACTB, SRF, ANPEP, CSN1S1
7diarrhea30.3CSN1S1, ALB
8food allergy30.2CCL11, CSN3, CSN1S1, IGHE, RNASE3, IL5
9asthma30.2CCL11, CSN1S1, PRG2, IGHE, RNASE3, IL5
10peritonitis30.0LACTB, ALB
11crohn's disease30.0ALB
12dermatitis29.9IL5, BTD, IGHE, CCL11
13bronchitis29.9LACTB, IL5, RNASE3, IGHE, CCL11
14pneumonia29.9LACTB, IL5, CCL11
15churg-strauss syndrome29.9IL5, RNASE3
16gastric ulcer29.9HGF, SRF
17influenza29.9LACTB, CCL11
18hepatitis29.9HGF, CCL11, ANPEP
19eosinophilic pneumonia29.7IL5, RNASE3, IGHE, CCL11
20leukemia29.7CCL11, PRG2, ANPEP, RNASE3, SRF, LACTB
21meningitis29.7ALB, LACTB
22skin disease29.7CCL11, IGHE, RNASE3, IL5, SRF
23urticaria29.7CSN1S1, PRG2, IGHE, RNASE3
24pulmonary fibrosis29.7HGF, PRG2
25allergic asthma29.7CCL11, IGHE, RNASE3, IL5
26atherosclerosis29.7ALB, SRF, ANPEP, CCL11
27hypertension29.7ALB
28cholera29.7CCL11, CSN1S1
29celiac disease29.7CSN1S1
30liver cirrhosis29.7ALB, LACTB, CSN1S1, HGF
31angioedema29.7IGHE, RNASE3, IL5
32ulcerative colitis29.7SRF, RNASE3, CSN1S1, CCL11
33encephalomyelitis29.7ANPEP
34duodenitis10.3
35protein-losing enteropathy10.3
36irritable bowel syndrome10.3
37reactive arthritis10.2
38pyloric stenosis10.2
39cryptosporidiosis10.2
40dysentery10.2
41listeriosis10.1
42duodenal obstruction10.1
43acute pancreatitis10.0
44acute diarrhea10.0
45intussusception10.0
46cholangitis10.0
47inflammatory bowel disease10.0
48eosinophilic enteropathy10.0
49atopic dermatitis10.0CCL11, CSN3, CSN1S1, PRG2, IGHE, RNASE3
50hypereosinophilic syndrome10.0CCL11, PRG2, IGHE, RNASE3, IL5

Graphical network of the top 20 diseases related to Gastroenteritis:



Diseases related to gastroenteritis

Clinical Features for Gastroenteritis

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Drugs & Therapeutics for Gastroenteritis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Gastroenteritis

Drug clinical trials:

Search ClinicalTrials for Gastroenteritis

Search NIH Clinical Center for Gastroenteritis

Search CenterWatch for Gastroenteritis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Gastroenteritis

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Anatomical Context for Gastroenteritis

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32MalaCards
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MalaCards organs/tissues related to Gastroenteritis:

32
Kidney, Small intestine, Testes, Colon, Liver, Pancreas, Bone, T cells, Pituitary, Thyroid, Bone marrow, Lung, Eye, Skin, Tonsil

Animal Models for Gastroenteritis or affiliated genes

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Publications for Gastroenteritis

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Sources:
50PubMed
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Articles related to Gastroenteritis:

(show top 50)    (show all 875)
idTitleAuthorsYear
1
Hospital-based Surveillance for Rotavirus Gastroenteritis in Children Younger Than 5 Years of Age in Ethiopia: 2007-2012. (24343610)
2014
2
Acute kidney injury after acute gastroenteritis in an infant with hereditary hypouricemia. (23652934)
2014
3
Successful discharge of children with gastroenteritis requiring intravenous rehydration. (23993936)
2014
4
Epidemiological and clinical characteristics of acute gastroenteritis according to their etiology (rotavirus or other) in children younger than 5 years old at a private institution in the city of Buenos Aires. (23732348)
2013
5
Impact of the Family Health Program on gastroenteritis in children in Bahia, Northeast Brazil: an analysis of primary care-sensitive conditions. (23932060)
2013
6
Correspondence on "Clinical Characterization of Gastroenteritis-Related Seizures in Children: Impact of Fever and Serum Sodium Levels" (23945928)
2013
7
Nontyphoidal Salmonella Infection in Children with Acute Gastroenteritis: Prevalence, Serotypes, and Antimicrobial Resistance in Shanghai, China. (24313784)
2013
8
Heat waves, incidence of infectious gastroenteritis, and relapse rates of inflammatory bowel disease: a retrospective controlled observational study. (23939628)
2013
9
Rapid adoption of Lactobacillus rhamnosus GG for acute gastroenteritis. (23457156)
2013
10
Risk of Norovirus Gastroenteritis from Consumption of Vegetables Irrigated with Highly Treated Municipal Wastewater-Evaluation of Methods to Estimate Sewage Quality. (24286258)
2013
11
Identification of cellular proteome using two-dimensional difference gel electrophoresis in ST cells infected with transmissible gastroenteritis coronavirus. (23855489)
2013
12
Antiviral effects of a probiotic Enterococcus faecium strain against transmissible gastroenteritis coronavirus. (23188495)
2013
13
Regulation of ROS in transmissible gastroenteritis virus-activated apoptotic signaling. (24225120)
2013
14
Enhanced therapeutic response with addition of loratadine in subserosal eosinophilic gastroenteritis. (23348189)
2013
15
Protection of montelukast on OVA-induced eosinophilic gastroenteritis via modulating IL-5, eotaxin-1 and MBP expression. (23855447)
2013
16
Burden of norovirus gastroenteritis in the ambulatory setting--United States, 2001-2009. (23300161)
2013
17
Astrovirus gastroenteritis in hospitalized children of less than 5 years of age in Taiwan, 2009. (22209687)
2012
18
Detection of human bocaviruses 1, 2 and 3 in Irish children presenting with gastroenteritis. (22614812)
2012
19
Acute gastroenteritis disease: Report of the FISPGHAN Working Group. (22983379)
2012
20
All-cause gastroenteritis and rotavirus-coded hospitalizations among US children, 2000-2009. (22543022)
2012
21
Outbreaks of acute gastroenteritis transmitted by person-to-person contact--United States, 2009-2010. (23235338)
2012
22
Gastroenteritis in children: Part II. Prevention and management. (22962878)
2012
23
Prevalence of norovirus infection in children and adults with acute gastroenteritis, Tehran, Iran, 2008-2009. (23412762)
2012
24
Global study of viral diarrhea in hospitalized children in Spain: results of structural surveillance of viral gastroenteritis net work (VIGESS-net) 2006-2008. (21963269)
2011
25
Antiemetics for reducing vomiting related to acute gastroenteritis in children and adolescents. (21901699)
2011
26
Fecal contamination of drinking water supplies in and around Chandigarh and correlation with acute gastroenteritis. (23781632)
2011
27
Molecular epidemiology of enteric viruses in children with sporadic gastroenteritis in Valencia, Venezuela. (21915873)
2011
28
Eosinophilic gastroenteritis in a young man. (20956505)
2011
29
Benign afebrile convulsions in the course of mild acute gastroenteritis: a study of 28 patients and a literature review. (22068069)
2011
30
Patient volume and quality of care for young children hospitalized with acute gastroenteritis. (21893651)
2011
31
MEFV gene mutations in a patient with eosinophilic gastroenteritis. (20890251)
2010
32
Benign convulsions with mild gastroenteritis: is it associated with sodium channel gene SCN1A mutation? (20519669)
2010
33
Rotavirus gastroenteritis complicated with toxic megacolon. (19650837)
2009
34
Adult eosinophilic gastroenteritis and hypereosinophilic syndromes. (19058302)
2008
35
The diagnostic value of serum interleukins 6 and 8 in children with acute gastroenteritis. (16819373)
2006
36
Eosinophilic gastroenteritis presenting as acute gastric perforation. (17130750)
2006
37
Molecular and experimental virulence of Listeria monocytogenes strains isolated from cases with invasive listeriosis and febrile gastroenteritis. (15708319)
2005
38
Rebound eosinophilia after treatment of hypereosinophilic syndrome and eosinophilic gastroenteritis with monoclonal anti-IL-5 antibody SCH55700. (15577851)
2004
39
A case of eosinophilic gastroenteritis: observation of serum IL-5 and sIL-2R levels before and after remission]. (15187490)
2004
40
Eosinophilic gastroenteritis masquerading as ampullary adenoma. (11873104)
2002
41
A randomized clinical trial comparing oral ondansetron with placebo in children with vomiting from acute gastroenteritis. (11919526)
2002
42
Pediatric eosinophilic gastroenteritis: report of one case. (11100528)
2000
43
Aeromonas sobria infection with severe soft tissue damage and segmental necrotizing gastroenteritis in a patient with alcoholic liver cirrhosis. (10469397)
1999
44
Eosinophilic gastroenteritis with esophageal involvement. (8688708)
1996
45
Pancreatic and biliary obstruction due to eosinophilic gastroenteritis. (2239893)
1990
46
Near fatal eosinophilic gastroenteritis responding to oral sodium chromoglycate. (3143628)
1988
47
The patient with gastroenteritis. Module 1. Epidemiology and etiology of acute diarrhea. (3728302)
1986
48
Eosinophilic gastroenteritis in extreme allergy. Immunopathological comparison with nonallergic gastrointestinal disease. (456850)
1979
49
Co-existent eosinophilic gastroenteritis and hypothalamic-pituitary dysfunction. (882484)
1977
50
Eosinophilic cystitis associated with eosinophilic gastroenteritis. (4814420)
1974

Genetic Variations for Gastroenteritis

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Expression for genes affiliated with Gastroenteritis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gastroenteritis

Search GEO for disease gene expression data for Gastroenteritis.

Pathways for genes affiliated with Gastroenteritis

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29KEGG, 37NCBI BioSystems Database
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Pathways related to Gastroenteritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5IL5, RNASE3, PRG2, CCL11
210.5IL5, IGHE, CCL11

Compounds for genes affiliated with Gastroenteritis

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Sources:
44Novoseek, 28IUPHAR, 24HMDB, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Gastroenteritis according to GeneCards/GeneDecks:

(show top 50)    (show all 134)
idCompoundScoreTop Affiliating Genes
1histamine44 28 2413.0CCL11, HGF, RNASE3, PRG2, IGHE, IL5
2prednisolone44 28 1113.0IL5, ALB, HGF, CSN1S1, IGHE, RNASE3
3allergens4411.0IGHE, CCL11, CSN3, CSN1S1, PRG2, RNASE3
4lactate4411.0CSN1S1, BTD, RNASE3, SRF, ALB, ANPEP
5arginine4410.9RNASE3, HGF, CSN1S1, PRG2, ANPEP, IGHE
6unicap4410.9IGHE, CCL11, IL5, RNASE3
7sodium cromoglycate4410.9RNASE3, IL5, CCL11, IGHE
8heparin44 28 11 2413.9PRG2, CCL11, RNASE3, SRF, CSN1S1
9pgd24410.9IL5, RNASE3, IGHE, PRG2, CCL11
10cetirizine44 28 11 2413.9IL5, IGHE, CCL11, RNASE3
11methacholine44 1111.9IL5, PRG2, CCL11, IGHE, RNASE3
12alanine4410.9HGF, ALB, CCL11, SRF, BTD, IGHE
13ketotifen44 1111.9IL5, IGHE, CCL11, RNASE3
14retinoic acid44 2411.9PRG2, HGF, IL5, RNASE3, SRF, CSN1S1
15montelukast44 49 28 1113.9CCL11, IL5, IGHE, RNASE3
16pge24410.9RNASE3, CCL11, SRF, IL5, ANPEP, CSN1S1
17sulfamethoxazole44 49 1112.9ALB, IGHE, IL5, LACTB
18ltc44410.9IL5, PRG2, RNASE3, CCL11
19budesonide44 49 1112.9CCL11, RNASE3, IL5, IGHE
20salbutamol44 49 28 11 2414.9IGHE, CCL11, RNASE3, IL5
21indomethacin44 59 28 1113.9ALB, IL5, IGHE, CCL11, HGF, PRG2
22fluticasone propionate44 49 59 1113.9IL5, RNASE3, IGHE, CCL11
23creatinine4410.9ALB, IGHE, SRF, RNASE3, CSN1S1, MDH2
24beclomethasone dipropionate4410.9RNASE3, IL5, IGHE
25anti-histamine4410.9RNASE3, CCL11, IGHE
26thyroxine44 2411.9ANPEP, CSN1S1, ALB, IL5, IGHE
27ovomucoid4410.9IGHE, CSN1S1, IL5
28toluene diisocyanate4410.9IL5, RNASE3, IGHE
29lte44410.9RNASE3, CCL11, IL5
30lactose44 1111.8CSN3, CSN1S1, ANPEP, IL5
31nedocromil sodium4410.8RNASE3, IL5, IGHE
32capsaicin44 2811.8HGF, IGHE, RNASE3, IL5
33genistein44 28 59 2 11 2415.8SRF, CCL11, HGF, CSN1S1, PRG2, IL5
34pranlukast44 28 1112.8RNASE3, CCL11, IL5
35cyclosporin a44 28 5912.8CCL11, HGF, SRF, IL5, RNASE3, IGHE
36ceftriaxone44 1111.8IL5, LACTB, ALB
37dexamethasone44 49 28 1113.8IGHE, SRF, IL5, HGF, CCL11, RNASE3
38vitamin a44 11 2412.8IGHE, CSN1S1, HGF, SRF
39methotrexate44 49 1112.8IGHE, IL5, ALB, HGF, SRF
40praziquantel44 1111.7RNASE3, IGHE, IL5
41agar4410.7IL5, HGF, CSN1S1, LACTB, SRF
42salmeterol44 49 28 1113.7IL5, RNASE3, CCL11
43superoxide44 2411.6MDH2, PRG2, SRF
44penicillin4410.6LACTB, IGHE, IL5
45gliadin4410.6RNASE3, CSN1S1, IGHE
46azelastine44 1111.6RNASE3, IL5, IGHE
47glutamate4410.5SRF, IL5, ANPEP, MDH2, CSN1S1, HGF
48itraconazole44 1111.5CSN1S1, IGHE, IL5
49matrigel4410.4CSN1S1, ANPEP, CCL11
50aspartate4410.2CSN1S1, HGF, MDH2, IGHE, ANPEP, ALB

GO Terms for genes affiliated with Gastroenteritis

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16Gene Ontology
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Cellular components related to Gastroenteritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.5ALB, CCL11, CSN3, CSN1S1, PRG2, PRB3

Products for genes affiliated with Gastroenteritis

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  • Antibodies
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Sources for Gastroenteritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet