MCID: GST045
MIFTS: 53

Gastroenteritis malady

Gastrointestinal diseases category

Summaries for Gastroenteritis

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Have you ever had the "stomach flu?" what you probably had was gastroenteritis - not a type of flu at all. gastroenteritis is an inflammation of the lining of the intestines caused by a virus, bacteria or parasites. viral gastroenteritis is the second most common illness in the u.s. the cause is often a norovirus infection. it spreads through contaminated food or water, and contact with an infected person. the best prevention is frequent hand washing. symptoms of gastroenteritis include diarrhea, abdominal pain, vomiting, headache, fever and chills. most people recover with no treatment. the most common problem with gastroenteritis is dehydration. this happens if you do not drink enough fluids to replace what you lose through vomiting and diarrhea. dehydration is most common in babies, young children, the elderly and people with weak immune systems. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Gastroenteritis, also known as cholera morbus, is related to eosinophilic gastroenteritis and pancreatitis. An important gene associated with Gastroenteritis is IL5 (interleukin 5 (colony-stimulating factor, eosinophil)), and among its related pathways are Allograft rejection and IL4-mediated signaling events. The drug erythromycin pwdr and the compounds histamine and prednisolone have been mentioned in the context of this disorder. Affiliated tissues include kidney, small intestine and testes.

Disease Ontology:8 A gastrointestinal system infectious disease that involves inflammation of the lining of the stomach and small and large intestines, which is caused by viruses, bacteria, or parasites. chemicals and drugs also cause gastroenteritis. the symptoms include diarrhea, loss of appetite, nausea, vomiting, cramps, and discomfort in the abdomen.

Wikipedia:63 Gastroenteritis or infectious diarrhea is a medical condition characterized by inflammation (\"-itis\")... more...

Aliases & Classifications for Gastroenteritis

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

gastroenteritis 8 10 44 33 60
cholera morbus 8 60
infectious colitis, enteritis and gastroenteritis 8


External Ids:

Disease Ontology8 DOID:2326
MeSH34 D005759
NCIt39 C34632

Related Diseases for Gastroenteritis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Gastroenteritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 227)
idRelated DiseaseScoreTop Affiliating Genes
1eosinophilic gastroenteritis31.6CCL11, CSN1S1, IGHE, IL5
2pancreatitis30.5ALB
3eosinophilic esophagitis30.4CCL11, IL5
4esophagitis30.4IL5, PRG2, CCL11
5eosinophilia30.4SRF, IL5, RNASE3, IGHE, PRG2, CCL11
6arthritis30.4ALB, LACTB, SRF, ANPEP, CSN1S1
7diarrhea30.3CSN1S1, ALB
8food allergy30.2CCL11, CSN3, CSN1S1, IGHE, RNASE3, IL5
9asthma30.2CCL11, CSN1S1, PRG2, IGHE, RNASE3, IL5
10peritonitis30.0LACTB, ALB
11crohn's disease30.0ALB
12dermatitis29.9IL5, BTD, IGHE, CCL11
13bronchitis29.9LACTB, IL5, RNASE3, IGHE, CCL11
14pneumonia29.9LACTB, IL5, CCL11
15churg-strauss syndrome29.9IL5, RNASE3
16gastric ulcer29.9HGF, SRF
17influenza29.9LACTB, CCL11
18hepatitis29.9HGF, CCL11, ANPEP
19eosinophilic pneumonia29.7IL5, RNASE3, IGHE, CCL11
20leukemia29.7CCL11, PRG2, ANPEP, RNASE3, SRF, LACTB
21meningitis29.7ALB, LACTB
22skin disease29.7CCL11, IGHE, RNASE3, IL5, SRF
23urticaria29.7CSN1S1, PRG2, IGHE, RNASE3
24pulmonary fibrosis29.7HGF, PRG2
25allergic asthma29.7CCL11, IGHE, RNASE3, IL5
26atherosclerosis29.7ALB, SRF, ANPEP, CCL11
27hypertension29.7ALB
28cholera29.7CCL11, CSN1S1
29celiac disease29.7CSN1S1
30liver cirrhosis29.7ALB, LACTB, CSN1S1, HGF
31angioedema29.7IGHE, RNASE3, IL5
32ulcerative colitis29.7SRF, RNASE3, CSN1S1, CCL11
33encephalomyelitis29.7ANPEP
34duodenitis10.3
35protein-losing enteropathy10.3
36irritable bowel syndrome10.3
37reactive arthritis10.2
38pyloric stenosis10.2
39cryptosporidiosis10.2
40dysentery10.2
41listeriosis10.1
42duodenal obstruction10.1
43acute pancreatitis10.0
44acute diarrhea10.0
45intussusception10.0
46cholangitis10.0
47inflammatory bowel disease10.0
48eosinophilic enteropathy10.0
49atopic dermatitis10.0CCL11, CSN3, CSN1S1, PRG2, IGHE, RNASE3
50hypereosinophilic syndrome10.0CCL11, PRG2, IGHE, RNASE3, IL5

Graphical network of the top 20 diseases related to Gastroenteritis:



Diseases related to gastroenteritis

Clinical Features for Gastroenteritis

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Drugs & Therapeutics for Gastroenteritis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Gastroenteritis

Drug clinical trials:

Search ClinicalTrials for Gastroenteritis

Search NIH Clinical Center for Gastroenteritis

Search CenterWatch for Gastroenteritis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Gastroenteritis

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Anatomical Context for Gastroenteritis

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32MalaCards
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MalaCards organs/tissues related to Gastroenteritis:

32
Kidney, Small intestine, Testes, Colon, Liver, Bone, T cells, Pancreas, Tonsil, Bone marrow, Skin, Thyroid, Lung, Eye, Pituitary

Animal Models for Gastroenteritis or affiliated genes

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Publications for Gastroenteritis

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50PubMed
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Articles related to Gastroenteritis:

(show top 50)    (show all 875)
idTitleAuthorsYear
1
Effectiveness of a multifactorial handwashing program to reduce school absenteeism due to acute gastroenteritis. (24096730)
2014
2
Epidemiology of rotavirus diarrhea and diversity of rotavirus strains among children less than 5 years of age with acute gastroenteritis in mauritius: june 2008 to december 2010. (24343614)
2014
3
Comparison of rectal swabs and faeces for real-time PCR detection of enteric agents in Rwandan children with gastroenteritis. (24073740)
2013
4
Duration of immunity to norovirus gastroenteritis. (23876612)
2013
5
The role of household transmission in an outbreak of viral gastroenteritis in a primary school in Liverpool, England. (23972357)
2013
6
Genetic analysis of PRRT2 for benign infantile epilepsy, infantile convulsions with choreoathetosis syndrome, and benign convulsions with mild gastroenteritis. (23073245)
2013
7
Development of Norwalk virus-specific monoclonal antibodies with therapeutic potential for the treatment of Norwalk virus gastroenteritis. (23785216)
2013
8
Transmissible gastroenteritis virus infection induces cell cycle arrest at S and G2/M phases via p53-dependent pathway. (24095767)
2013
9
Incidence and characteristics of sporadic norovirus gastroenteritis associated with hospitalization of children less than 5 years of age in Israel. (23411623)
2013
10
Estimating rotavirus gastroenteritis hospitalisations by using hospital episode statistics before and after the introduction of rotavirus vaccine in Australia. (23246261)
2013
11
Monoclonal antibody against membrane protein of transmissible gastroenteritis virus. (23600504)
2013
12
Whole genome sequence analysis of bovine G6P[11] rotavirus strain found in a child with gastroenteritis. (22995281)
2013
13
Parasitic gastroenteritis and fasciolosis widely reported in sheep. (23475043)
2013
14
A survey of emergency department resources and strategies employed in the treatment of pediatric gastroenteritis. (23701343)
2013
15
Efficacy of a pentavalent human-bovine reassortant rotavirus vaccine against rotavirus gastroenteritis among American Indian children. (22252206)
2012
16
Genetic characterization of sapovirus detected in hospitalized children with acute gastroenteritis in Korea. (23289192)
2012
17
Campylobacter gastroenteritis associated with Sweet's syndrome. (22723255)
2012
18
Diagnostic performance of serum interleukin-6 and interleukin-10 levels and clinical predictors in children with rotavirus and norovirus gastroenteritis. (22592039)
2012
19
Acute motor-sensory axonal Guillain-BarrAc syndrome with unilateral facial nerve paralysis after rotavirus gastroenteritis in a 2-year-old boy. (21915637)
2012
20
Ulcerative colitis presenting as acute infectious gastroenteritis with a paralytic ileus. (22605860)
2012
21
Changes in causes of acute gastroenteritis in the United Kingdom over 15 years: microbiologic findings from 2 prospective, population-based studies of infectious intestinal disease. (22412058)
2012
22
Factors affecting prevention and control of viral gastroenteritis outbreaks in care homes. (22926136)
2012
23
Molecular detection and epidemiology of astrovirus, bocavirus, and sapovirus in Italian children admitted to hospital with acute gastroenteritis, 2008-2009. (22337304)
2012
24
Gastroenteritis outbreaks in elderly homes in the east of France during winter 2009/10: aetiology research for a series of 37 outbreaks. (22401565)
2012
25
Norovirus gastroenteritis in immunocompromised patients. (23190223)
2012
26
Comment to case report on eosinophilic gastroenteritis. (21646676)
2011
27
Randomized clinical trial of rapid versus 24-hour rehydration for children with acute gastroenteritis. (21949149)
2011
28
Two New Zealand outbreaks of norovirus gastroenteritis linked to commercially farmed oysters. (22237569)
2011
29
Central diabetes insipidus misdiagnosed as acute gastroenteritis in a pediatric patient. (18826743)
2008
30
Effects of enteral and parenteral nutrition on gastroenteric hormones and gastric motility after subtotal gastrectomy. (18686631)
2008
31
Emphysematous pyelonephritis presenting as gastroenteritis. (18090885)
2007
32
Eosinophilic gastroenteritis of the pancreas: an unusual cause of obstructive jaundice. (16917405)
2006
33
Eosinophilic gastroenteritis associated with systemic lupus erythematosus. (16145355)
2005
34
Ghrelin in gastroenteric pathophysiology. (16370568)
2005
35
Eosinophilic gastroenteritis and gluten-sensitive enteropathy in the same patient. (11960068)
2002
36
Rotavirus gastroenteritis possibly causing reye syndrome. (10852203)
2000
37
Laryngeal cleft and eosinophilic gastroenteritis: report of 2 cases. (10680877)
2000
38
Food poisoning, listeriosis, and febrile gastroenteritis. (9155220)
1997
39
Interspecies aminopeptidase-N chimeras reveal species-specific receptor recognition by canine coronavirus, feline infectious peritonitis virus, and transmissible gastroenteritis virus. (8985407)
1997
40
Eosinophilic gastroenteritis. (8775302)
1995
41
Antiviral action of interferon-alpha against porcine transmissible gastroenteritis virus. (7653029)
1995
42
Eosinophilic ascites without eosinophilia: a unique presentation of serosal eosinophilic gastroenteritis. (8338104)
1993
43
Eosinophilic gastroenteritis: 10 years experience. (8420276)
1993
44
Eosinophilic gastroenteritis. (8333365)
1993
45
Eosinophilic gastroenteritis. (2023169)
1991
46
Eosinophilic gastroenteritis--a rare cause of severe abdominal pain. Case report. (1678637)
1991
47
Eosinophilic gastroenteritis presenting with biliary and duodenal obstruction. (3605038)
1987
48
Lactose intolerance in pateints with gastroenteritis between 0--2 years of age. (800247)
1976
49
Eosinophilic gastroenteritis with malabsorption, extensive villous atrophy, recurrent hemorrhage and chronic pulmonary fibrosis. (1080012)
1975
50
Pancreatitis and eosinophilic gastroenteritis. (4707722)
1973

Genetic Variations for Gastroenteritis

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Expression for genes affiliated with Gastroenteritis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gastroenteritis

Search GEO for disease gene expression data for Gastroenteritis.

Pathways for genes affiliated with Gastroenteritis

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29KEGG, 37NCBI BioSystems Database
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Pathways related to Gastroenteritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5IL5, RNASE3, PRG2, CCL11
210.5IL5, IGHE, CCL11

Compounds for genes affiliated with Gastroenteritis

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Sources:
44Novoseek, 28IUPHAR, 24HMDB, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Gastroenteritis according to GeneCards/GeneDecks:

(show top 50)    (show all 134)
idCompoundScoreTop Affiliating Genes
1histamine44 28 2413.0CCL11, HGF, RNASE3, PRG2, IGHE, IL5
2prednisolone44 28 1113.0IL5, ALB, HGF, CSN1S1, IGHE, RNASE3
3allergens4411.0IGHE, CCL11, CSN3, CSN1S1, PRG2, RNASE3
4lactate4411.0CSN1S1, BTD, RNASE3, SRF, ALB, ANPEP
5arginine4410.9RNASE3, HGF, CSN1S1, PRG2, ANPEP, IGHE
6unicap4410.9IGHE, CCL11, IL5, RNASE3
7sodium cromoglycate4410.9RNASE3, IL5, CCL11, IGHE
8heparin44 28 11 2413.9PRG2, CCL11, RNASE3, SRF, CSN1S1
9pgd24410.9IL5, RNASE3, IGHE, PRG2, CCL11
10cetirizine44 28 11 2413.9IL5, IGHE, CCL11, RNASE3
11methacholine44 1111.9IL5, PRG2, CCL11, IGHE, RNASE3
12alanine4410.9HGF, ALB, CCL11, SRF, BTD, IGHE
13ketotifen44 1111.9IL5, IGHE, CCL11, RNASE3
14retinoic acid44 2411.9PRG2, HGF, IL5, RNASE3, SRF, CSN1S1
15montelukast44 49 28 1113.9CCL11, IL5, IGHE, RNASE3
16pge24410.9RNASE3, CCL11, SRF, IL5, ANPEP, CSN1S1
17sulfamethoxazole44 49 1112.9ALB, IGHE, IL5, LACTB
18ltc44410.9IL5, PRG2, RNASE3, CCL11
19budesonide44 49 1112.9CCL11, RNASE3, IL5, IGHE
20salbutamol44 49 28 11 2414.9IGHE, CCL11, RNASE3, IL5
21indomethacin44 59 28 1113.9ALB, IL5, IGHE, CCL11, HGF, PRG2
22fluticasone propionate44 49 59 1113.9IL5, RNASE3, IGHE, CCL11
23creatinine4410.9ALB, IGHE, SRF, RNASE3, CSN1S1, MDH2
24beclomethasone dipropionate4410.9RNASE3, IL5, IGHE
25anti-histamine4410.9RNASE3, CCL11, IGHE
26thyroxine44 2411.9ANPEP, CSN1S1, ALB, IL5, IGHE
27ovomucoid4410.9IGHE, CSN1S1, IL5
28toluene diisocyanate4410.9IL5, RNASE3, IGHE
29lte44410.9RNASE3, CCL11, IL5
30lactose44 1111.8CSN3, CSN1S1, ANPEP, IL5
31nedocromil sodium4410.8RNASE3, IL5, IGHE
32capsaicin44 2811.8HGF, IGHE, RNASE3, IL5
33genistein44 28 59 2 11 2415.8SRF, CCL11, HGF, CSN1S1, PRG2, IL5
34pranlukast44 28 1112.8RNASE3, CCL11, IL5
35cyclosporin a44 28 5912.8CCL11, HGF, SRF, IL5, RNASE3, IGHE
36ceftriaxone44 1111.8IL5, LACTB, ALB
37dexamethasone44 49 28 1113.8IGHE, SRF, IL5, HGF, CCL11, RNASE3
38vitamin a44 11 2412.8IGHE, CSN1S1, HGF, SRF
39methotrexate44 49 1112.8IGHE, IL5, ALB, HGF, SRF
40praziquantel44 1111.7RNASE3, IGHE, IL5
41agar4410.7IL5, HGF, CSN1S1, LACTB, SRF
42salmeterol44 49 28 1113.7IL5, RNASE3, CCL11
43superoxide44 2411.6MDH2, PRG2, SRF
44penicillin4410.6LACTB, IGHE, IL5
45gliadin4410.6RNASE3, CSN1S1, IGHE
46azelastine44 1111.6RNASE3, IL5, IGHE
47glutamate4410.5SRF, IL5, ANPEP, MDH2, CSN1S1, HGF
48itraconazole44 1111.5CSN1S1, IGHE, IL5
49matrigel4410.4CSN1S1, ANPEP, CCL11
50aspartate4410.2CSN1S1, HGF, MDH2, IGHE, ANPEP, ALB

GO Terms for genes affiliated with Gastroenteritis

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16Gene Ontology
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Cellular components related to Gastroenteritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.5ALB, CCL11, CSN3, CSN1S1, PRG2, PRB3

Products for genes affiliated with Gastroenteritis

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Sources for Gastroenteritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet