MCID: GST012
MIFTS: 39

Gastroesophageal Junction Adenocarcinoma malady

Cancer diseases, Gastrointestinal diseases, Cardiovascular diseases categories
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Summaries for Gastroesophageal Junction Adenocarcinoma

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MalaCards based summary: Gastroesophageal Junction Adenocarcinoma, also known as adenocarcinoma of cardioesophageal junction, is related to adenocarcinoma and meningitis. An important gene associated with Gastroesophageal Junction Adenocarcinoma is TYMS (thymidylate synthetase), and among its related pathways are Alpha6-Beta4 Integrin Signaling Pathway and Agrin Interactions at Neuromuscular Junction. The compounds capecitabine and levamisole have been mentioned in the context of this disorder. Affiliated tissues include lymph node, liver and testes, and related mouse phenotype tumorigenesis.

Aliases & Classifications for Gastroesophageal Junction Adenocarcinoma

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Gastroesophageal Junction Adenocarcinoma, Aliases & Descriptions:

Name: Gastroesophageal Junction Adenocarcinoma 8
Adenocarcinoma of Cardioesophageal Junction 8 62
 
Adenocarcinoma of the Gastroesophageal Junction 62


Classifications:



External Ids:

Disease Ontology8 DOID:4944
NCIt39 C9296

Related Diseases for Gastroesophageal Junction Adenocarcinoma

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Diseases related to Gastroesophageal Junction Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 37)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.2PTK2, ERBB2, TYMS, CDK6
2meningitis30.3PTK2, IL1B
3esophagitis10.5
4biliary tract neoplasm10.3TYMS, ERBB2
5factor vii deficiency10.3ERBB2, TYMS
6toxic shock syndrome10.3IL1B, TYMS
7h. pylori infection10.2
8diarrhea10.2ERBB2, TYMS
9salivary gland adenoid cystic carcinoma10.2DYT10, ERBB2
10monocytic leukemia10.0IL1B, DYT10
11neutropenia10.0ERBB2, TYMS
12idiopathic pulmonary fibrosis10.0IL1B, DYT10
13t-cell leukemia10.0CDK6, TYMS, DYT10
14osteosarcoma10.0TYMS, DYT10, EXT1
15acute lymphoblastic leukemia10.0CDK6, TYMS, DYT10
16cervical cancer10.0TYMS, ERBB2, PTK2
17stomach cancer10.0TYMS, IL1B, ERBB2
18colorectal cancer9.9ERBB2, TYMS, PTK2
19ovarian cancer9.9TYMS, PTK2, ERBB2
20endometrial carcinoma9.9PTK2, ERBB2, CDK6
21colon adenocarcinoma9.9DYT10, TYMS, PTK2
22cholangiocarcinoma9.9PTK2, DYT10, ERBB2
23sarcoma9.8EXT1, CDK6, PTK2
24lung adenocarcinoma9.8PTK2, DYT10, ERBB2
25colonic benign neoplasm9.8DYT10, TYMS, PTK2
26astrocytoma9.8DYT10, IL1B, PTK2
27squamous cell carcinoma of the head and neck9.7PTK2, ERBB2, CDK6, TYMS
28non-small cell lung carcinoma9.7ERBB2, PTK2, CDK6, TYMS
29pancreatic cancer9.7PTK2, TYMS, ERBB2, CDK6
30tongue squamous cell carcinoma9.7CDK6, TYMS, PTK2, ERBB2
31lung cancer9.7PTK2, ERBB2, DYT10, TYMS
32breast cancer9.7DYT10, TYMS, ERBB2, PTK2
33glioblastoma9.6DYT10, ERBB2, PTK2, CDK6
34atherosclerosis9.6IL1B, DYT10, PTK2
35prostate cancer9.6CDK6, DYT10, ERBB2, PTK2
36retinoblastoma9.5ERBB2, DYT10, PTK2, TYMS, CDK6
37leukemia9.4TYMS, PTK2, IL1B, DYT10, CDK6

Graphical network of the top 20 diseases related to Gastroesophageal Junction Adenocarcinoma:



Diseases related to gastroesophageal junction adenocarcinoma

Symptoms for Gastroesophageal Junction Adenocarcinoma

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Drugs & Therapeutics for Gastroesophageal Junction Adenocarcinoma

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Drug clinical trials:

Search ClinicalTrials for Gastroesophageal Junction Adenocarcinoma

Search NIH Clinical Center for Gastroesophageal Junction Adenocarcinoma

Genetic Tests for Gastroesophageal Junction Adenocarcinoma

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Anatomical Context for Gastroesophageal Junction Adenocarcinoma

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MalaCards organs/tissues related to Gastroesophageal Junction Adenocarcinoma:

32
Lymph node, Liver, Testes

Animal Models for Gastroesophageal Junction Adenocarcinoma or affiliated genes

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MGI Mouse Phenotypes related to Gastroesophageal Junction Adenocarcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.0CDK6, EXT1, ERBB2, IL1B, PTK2

Publications for Gastroesophageal Junction Adenocarcinoma

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Articles related to Gastroesophageal Junction Adenocarcinoma:

(show all 48)
idTitleAuthorsYear
1
Personalizing risk stratification by addition of PAK1 expression to TNM staging: Improving the accuracy of clinical decision for gastroesophageal junction adenocarcinoma. (25159681)
2014
2
Combined neutron brachytherapy with external beam radiation in patients with inoperable gastroesophageal junction adenocarcinoma. (25296599)
2014
3
Prognostic importance and therapeutic implications of PAK1, a drugable protein kinase, in gastroesophageal junction adenocarcinoma. (24236193)
2013
4
Meningeal carcinomatosis: a metastasis from gastroesophageal junction adenocarcinoma. (24454393)
2013
5
Results of docetaxel plus oxaliplatin (DOCOX) A+ cetuximab in patients with metastatic gastric and/or gastroesophageal junction adenocarcinoma: results of a randomised Phase 2 study. (23747051)
2013
6
Snail1 correlates with patient outcomes in E-cadherin-preserved gastroesophageal junction adenocarcinoma. (24356933)
2013
7
The metastasis-associated gene MTA3, a component of the Mi-2/NuRD transcriptional repression complex, predicts prognosis of gastroesophageal junction adenocarcinoma. (23671646)
2013
8
Distant lymph node metastases in gastroesophageal junction adenocarcinoma: impact of endoscopic ultrasound-guided fine-needle aspiration. (24949383)
2013
9
HER2 expression and relevant clinicopathological features in gastric and gastroesophageal junction adenocarcinoma in a Chinese population. (23656792)
2013
10
Gastroesophageal junction adenocarcinoma metastasizing to gingiva. (23776844)
2013
11
Reconstructive options for gastroesophageal junction adenocarcinoma after Roux-en-Y gastric bypass. (23988286)
2013
12
A phase II study of neoadjuvant docetaxel, oxaliplatin, and S-1 (DOS) chemotherapy followed by surgery and adjuvant S-1 chemotherapy in potentially resectable gastric or gastroesophageal junction adenocarcinoma. (23921575)
2013
13
Unanswered questions in the management of gastroesophageal junction adenocarcinoma. (23714486)
2013
14
The incidence and prognostic value of HER2 overexpression and cyclin D1 expression in patients with gastric or gastroesophageal junction adenocarcinoma in Israel. (23420289)
2013
15
HER2 expression in gastric and gastroesophageal junction adenocarcinoma in a US population: clinicopathologic analysis with proposed approach to HER2 assessment. (21617522)
2012
16
Postoperative intraperitoneal 5-fluoro-2'-deoxyuridine added to chemoradiation in patients curatively resected (R0) for locally advanced gastric and gastroesophageal junction adenocarcinoma. (21769462)
2012
17
Results of postoperative radiochemotherapy of the patients with resectable gastroesophageal junction adenocarcinoma in Slovenia. (23412351)
2012
18
HER2/neu gene amplification and protein overexpression in gastric and gastroesophageal junction adenocarcinoma: a review of histopathology, diagnostic testing, and clinical implications. (22646280)
2012
19
Relationship between gastroesophageal junction adenocarcinoma and Helicobacter pylori infection in Japan. (22472851)
2012
20
Preoperative chemotherapy with cisplatin and docetaxel followed by surgery and clip-oriented postoperative chemoradiation in patients with localized gastric or gastroesophageal junction adenocarcinoma: results from a phase II feasibility study. (21063792)
2011
21
A multicenter, phase II study of bortezomib (PS-341) in patients with unresectable or metastatic gastric and gastroesophageal junction adenocarcinoma. (20574790)
2011
22
Gastroesophageal junction adenocarcinoma of young patients who underwent curative surgery: a comparative analysis with older group. (21264755)
2011
23
Adjuvant bi-weekly combination of cisplatin, infusional 5-fluorouracil and folinic acid followed by concomitant chemoradiotherapy with infusional fluorouracil for high risk operated gastric and gastroesophageal junction adenocarcinoma. (21338186)
2010
24
Phase II study of sorafenib in combination with docetaxel and cisplatin in the treatment of metastatic or advanced gastric and gastroesophageal junction adenocarcinoma: ECOG 5203. (20458043)
2010
25
Phase II study of epirubicin, oxaliplatin and docetaxel combination in metastatic gastric or gastroesophageal junction adenocarcinoma. (19267943)
2009
26
Predictive value of initial PET-SUVmax in patients with locally advanced esophageal and gastroesophageal junction adenocarcinoma. (19487968)
2009
27
Transition in biology and philosophy in the treatment of gastroesophageal junction adenocarcinoma. (19139425)
2009
28
Local recurrence following adjuvant chemotherapy without radiotherapy in completely resected stomach and gastroesophageal junction adenocarcinoma. (19443416)
2009
29
Is radiation therapy needed in the treatment of gastroesophageal junction adenocarcinoma? (19343142)
2008
30
Molecular dissection of the chromosome band 7q21 amplicon in gastroesophageal junction adenocarcinomas identifies cyclin-dependent kinase 6 at both genomic and protein expression levels. (18438866)
2008
31
Irinotecan, docetaxel and oxaliplatin combination in metastatic gastric or gastroesophageal junction adenocarcinoma. (17667920)
2007
32
High-resolution array comparative genomic hybridization of chromosome 8q: evaluation of putative progression markers for gastroesophageal junction adenocarcinomas. (18000363)
2007
33
Lymph node involvement in advanced gastroesophageal junction adenocarcinoma. (17662776)
2007
34
The prevalence of Helicobacter pylori infection and the status of gastric acid secretion in patients with gastroesophageal junction adenocarcinoma in Japan. (17450443)
2007
35
Interleukin-1 genetic polymorphisms and their relationship to the cancer anorexia/weight loss syndrome in metastatic gastric and gastroesophageal junction adenocarcinoma. (17265786)
2007
36
Phase II study of cetuximab in combination with FOLFIRI in patients with untreated advanced gastric or gastroesophageal junction adenocarcinoma (FOLCETUX study). (17164226)
2007
37
New proposal for postsurgery pathologic staging of esophageal or gastroesophageal junction adenocarcinoma: why bother? (17327615)
2007
38
Multicentre phase II pharmacokinetic and pharmacodynamic study of OSI-7904L in previously untreated patients with advanced gastric or gastroesophageal junction adenocarcinoma. (16880795)
2006
39
Multicenter phase II study of irinotecan, cisplatin, and bevacizumab in patients with metastatic gastric or gastroesophageal junction adenocarcinoma. (17114652)
2006
40
A multi-center phase II study of sequential paclitaxel and bryostatin-1 (NSC 339555) in patients with untreated, advanced gastric or gastroesophageal junction adenocarcinoma. (16683077)
2006
41
Preservation of gastric acid secretion may be important for the development of gastroesophageal junction adenocarcinoma in Japanese people, irrespective of the H. pylori infection status. (16573782)
2006
42
Gastroesophageal junction adenocarcinoma: what are the factors influencing long-term survival? (16845860)
2006
43
Multicenter phase II trial of S-1 plus cisplatin in patients with untreated advanced gastric or gastroesophageal junction adenocarcinoma. (16446338)
2006
44
Comparison of the clinical and histological characteristics and survival of distal esophageal-gastroesophageal junction adenocarcinoma in patients with and without barrett mucosa. (15967904)
2005
45
Metastatic gastroesophageal junction adenocarcinoma to the extraocular muscles. (12578774)
2003
46
Gastroesophageal junction adenocarcinoma. (12057146)
2000
47
A phase II study of 5-fluorouracil, leucovorin, adriamycin, and cisplatin (FLAP) for metastatic gastric and gastroesophageal junction adenocarcinoma. A Penn Cancer Clinical Trial Group and Roswell Park Cancer Institute Community Oncology Research Program Trial. (9167745)
1997
48
Rapid progression of gastroesophageal junction adenocarcinoma after liver transplantation. (9013353)
1997

Variations for Gastroesophageal Junction Adenocarcinoma

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Expression for genes affiliated with Gastroesophageal Junction Adenocarcinoma

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Expression patterns in normal tissues for genes affiliated with Gastroesophageal Junction Adenocarcinoma

Search GEO for disease gene expression data for Gastroesophageal Junction Adenocarcinoma.

Pathways for genes affiliated with Gastroesophageal Junction Adenocarcinoma

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Pathways related to Gastroesophageal Junction Adenocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3ERBB2, PTK2
29.3ERBB2, PTK2
39.1CDK6, PTK2
4
Show member pathways
8.9PTK2, IL1B, ERBB2
5
Show member pathways
8.9PTK2, ERBB2, IL1B
68.8ERBB2, PTK2, CDK6
7
Show member pathways
Integrin-mediated cell adhesion37
Focal Adhesion37
8.8ERBB2, CDK6, PTK2
8
Show member pathways
8.4PTK2, IL1B, ERBB2, CDK6

Compounds for genes affiliated with Gastroesophageal Junction Adenocarcinoma

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Compounds related to Gastroesophageal Junction Adenocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1capecitabine44 50 1112.2ERBB2, TYMS
2levamisole44 1111.1ERBB2, TYMS
3risedronate44 50 28 61 1114.1IL1B, TYMS
45-methylthioadenosine4410.1ERBB2, TYMS
5taxane4410.0ERBB2, TYMS
6vinorelbine44 50 1112.0TYMS, ERBB2
7n-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide44 1110.9DYT10, ERBB2
8ag-126449.8DYT10, IL1B
9n,n-dimethylsphingosine44 6110.8DYT10, IL1B
10mezerein449.8IL1B, DYT10
11pd153035449.8DYT10, ERBB2
12cetuximab44 50 1111.8TYMS, ERBB2
13aacocf3449.8IL1B, DYT10
14gefitinib44 50 1111.7CDK6, ERBB2, TYMS
15methotrexate50 44 1111.7TYMS, ERBB2, IL1B
16staurosporin449.7DYT10, IL1B
17valine449.6CDK6, ERBB2, TYMS
18docetaxel44 50 61 1112.4ERBB2, TYMS, PTK2
19phorbol 12,13-dibutyrate449.3CDK6, DYT10
20quercetin44 61 24 1112.3PTK2, TYMS, IL1B
215fluorouracil449.3TYMS, ERBB2, PTK2
22curcumin449.3ERBB2, IL1B, PTK2
23resveratrol44 61 24 1112.2CDK6, PTK2, ERBB2
24egcg449.2PTK2, CDK6, ERBB2
25polymyxin b449.1DYT10, IL1B
26etoposide44 50 61 1112.1TYMS, PTK2, ERBB2
27ag 1478449.1DYT10, PTK2, ERBB2
28tgf beta1449.1CDK6, PTK2, IL1B
29carbachol44 28 1111.1DYT10, ERBB2, PTK2
30ro 31 8220449.1IL1B, DYT10, PTK2
31c2ceramide449.0IL1B, PTK2, DYT10
32gnrh449.0ERBB2, PTK2, DYT10
33rottlerin448.9CDK6, DYT10, PTK2
34calpeptin44 619.9DYT10, PTK2
35butyrate448.9CDK6, PTK2, TYMS
36cisplatin44 50 61 1111.9CDK6, ERBB2, PTK2, TYMS
37arginine448.9TYMS, EXT1, ERBB2, PTK2
38sb 20358044 619.7PTK2, DYT10, IL1B
39erbstatin448.7PTK2, IL1B, DYT10, ERBB2
40n acetylcysteine448.7IL1B, DYT10, ERBB2, PTK2
41dexamethasone44 50 28 1111.7PTK2, ERBB2, IL1B, CDK6
42genistein44 28 61 2 24 1113.7IL1B, ERBB2, DYT10, PTK2
43rapamycin448.6PTK2, DYT10, ERBB2, CDK6
44glutamate448.6PTK2, ERBB2, DYT10, TYMS
45cycloheximide448.4ERBB2, DYT10, IL1B, PTK2, TYMS
46vegf448.4ERBB2, DYT10, IL1B, PTK2, TYMS
47tamoxifen44 50 28 1111.3TYMS, PTK2, DYT10, ERBB2, CDK6
48herbimycin a44 619.2PTK2, IL1B, DYT10, ERBB2, CDK6
49ly294002448.2PTK2, IL1B, CDK6, ERBB2, DYT10
50serine448.2CDK6, ERBB2, PTK2, DYT10, TYMS

GO Terms for genes affiliated with Gastroesophageal Junction Adenocarcinoma

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Biological processes related to Gastroesophageal Junction Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axon guidanceGO:0074118.9EXT1, ERBB2, PTK2
2positive regulation of protein phosphorylationGO:0019348.6ERBB2, IL1B, PTK2

Products for genes affiliated with Gastroesophageal Junction Adenocarcinoma

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  • Antibodies
  • Proteins
  • Lysates

Sources for Gastroesophageal Junction Adenocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet