MCID: GST012
MIFTS: 33

Gastroesophageal Junction Adenocarcinoma malady

Gastrointestinal, Cardiovascular categories

Summaries for Gastroesophageal Junction Adenocarcinoma

Sources:
33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Gastroesophageal Junction Adenocarcinoma, also known as adenocarcinoma of the gastroesophageal junction, is related to adenocarcinoma and squamous cell carcinoma. An important gene associated with Gastroesophageal Junction Adenocarcinoma is PICK1 (protein interacting with PRKCA 1), and among its related pathways are Apoptosis Pathway and Toll-like Receptor Pathway. The compounds glutamate and capecitabine have been mentioned in the context of this disorder. Affiliated tissues include lymph node, liver and pancreas, and related mouse phenotype tumorigenesis.

Aliases & Classifications for Gastroesophageal Junction Adenocarcinoma

Sources:
8Disease Ontology, 61UMLS, 40NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal, Cardiovascular


Aliases & Descriptions:

gastroesophageal junction adenocarcinoma 8
adenocarcinoma of the gastroesophageal junction 61
adenocarcinoma of cardioesophageal junction 8


External Ids:

Disease Ontology8 DOID:4944
NCIt40 C9296

Related Diseases for Gastroesophageal Junction Adenocarcinoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Gastroesophageal Junction Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.5ERBB2, PTK2, CDK6, TYMS
2squamous cell carcinoma30.4TYMS, CDK6, PTK2, ERBB2
3h. pylori infection10.4
4cerebellar degeneration10.3
5paraneoplastic cerebellar degeneration10.3
6barrett's adenocarcinoma10.2
7gallbladder cancer10.0TYMS
8myeloma10.0IL1B
9peritonitis10.0IL1B
10adenoma10.0PTK2
11hepatocellular carcinoma10.0PTK2
12schizophrenia10.0PICK1
13fibrosarcoma10.0PTK2
14primary hyperoxaluria10.0IL1B
15papilloma10.0PTK2
16pancreatitis10.0IL1B
17neutropenia10.0ERBB2, TYMS
18oral cancer10.0DYT10
19biliary tract cancer10.0TYMS, ERBB2
20uremia10.0DYT10
21lung cancer10.0ERBB2, TYMS
22myeloid leukemia10.0DYT10
23gout10.0IL1B
24diarrhea10.0ERBB2, TYMS
25thyroid cancer10.0PTK2, CDK6
26factor vii deficiency10.0ERBB2, TYMS
27bladder carcinoma10.0ERBB2, TYMS
28stomach cancer10.0ERBB2, IL1B, TYMS
29chondrosarcoma10.0PTK2, EXT1
30malignant glioma10.0PTK2, DYT10
31adenoid cystic carcinoma10.0ERBB2, DYT10
32cervical cancer10.0TYMS, PTK2, ERBB2
33sarcoma10.0EXT1, CDK6, PTK2
34endometrial carcinoma10.0ERBB2, PTK2, CDK6
35osteosarcoma10.0EXT1, DYT10, TYMS
36colon adenocarcinoma10.0DYT10, TYMS, PTK2
37t-cell leukemia10.0CDK6, TYMS, DYT10
38colorectal cancer10.0ERBB2, PTK2, TYMS
39meningitis10.0IL1B, PTK2
40cholangiocarcinoma10.0DYT10, PTK2, ERBB2
41acute lymphocytic leukemia10.0CDK6, TYMS, DYT10
42squamous cell carcinoma of the head and neck10.0TYMS, CDK6, PTK2, ERBB2
43pancreatic cancer10.0ERBB2, PTK2, CDK6, TYMS
44ovarian cancer10.0ERBB2, PTK2, CDK6, TYMS
45lung adenocarcinoma10.0DYT10, PTK2, ERBB2
46non-small cell lung carcinoma10.0TYMS, CDK6, PTK2, ERBB2
47astrocytoma10.0PTK2, IL1B, DYT10
48melanoma10.0PTK2, CDK6, DYT10
49breast cancer10.0DYT10, TYMS, PTK2, ERBB2
50prostate cancer10.0ERBB2, PTK2, CDK6, DYT10

Graphical network of the top 20 diseases related to Gastroesophageal Junction Adenocarcinoma:



Diseases related to gastroesophageal junction adenocarcinoma

Clinical Features for Gastroesophageal Junction Adenocarcinoma

Drugs & Therapeutics for Gastroesophageal Junction Adenocarcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Gastroesophageal Junction Adenocarcinoma

Drug clinical trials:

Search ClinicalTrials for Gastroesophageal Junction Adenocarcinoma

Search NIH Clinical Center for Gastroesophageal Junction Adenocarcinoma

Search CenterWatch for Gastroesophageal Junction Adenocarcinoma

Genetic Tests for Gastroesophageal Junction Adenocarcinoma

Anatomical Context for Gastroesophageal Junction Adenocarcinoma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Gastroesophageal Junction Adenocarcinoma:

33
Lymph node, Liver, Pancreas

Animal Models for Gastroesophageal Junction Adenocarcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Gastroesophageal Junction Adenocarcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020067.8ERBB2, PTK2, IL1B, CDK6, EXT1

Publications for Gastroesophageal Junction Adenocarcinoma

Sources:
51PubMed
See all sources

Articles related to Gastroesophageal Junction Adenocarcinoma:

(show top 50)    (show all 60)
idTitleAuthorsYear
1
Results of docetaxel plus oxaliplatin (DOCOX) A+ cetuximab in patients with metastatic gastric and/or gastroesophageal junction adenocarcinoma: results of a randomised Phase 2 study. (23747051)
2013
2
Snail1 correlates with patient outcomes in E-cadherin-preserved gastroesophageal junction adenocarcinoma. (24356933)
2013
3
Gastroesophageal junction adenocarcinoma metastasizing to gingiva. (23776844)
2013
4
Reconstructive options for gastroesophageal junction adenocarcinoma after Roux-en-Y gastric bypass. (23988286)
2013
5
A phase II study of neoadjuvant docetaxel, oxaliplatin, and S-1 (DOS) chemotherapy followed by surgery and adjuvant S-1 chemotherapy in potentially resectable gastric or gastroesophageal junction adenocarcinoma. (23921575)
2013
6
HER2 gene amplification in esophageal squamous cell carcinoma is less than in gastroesophageal junction and gastric adenocarcinoma. (23946770)
2013
7
Genetic polymorphisms at TIMP3 are associated with survival of adenocarcinoma of the gastroesophageal junction. (23527119)
2013
8
The incidence and prognostic value of HER2 overexpression and cyclin D1 expression in patients with gastric or gastroesophageal junction adenocarcinoma in Israel. (23420289)
2013
9
HER2 expression in gastric and gastroesophageal junction adenocarcinoma in a US population: clinicopathologic analysis with proposed approach to HER2 assessment. (21617522)
2012
10
Postoperative intraperitoneal 5-fluoro-2'-deoxyuridine added to chemoradiation in patients curatively resected (R0) for locally advanced gastric and gastroesophageal junction adenocarcinoma. (21769462)
2012
11
Results of postoperative radiochemotherapy of the patients with resectable gastroesophageal junction adenocarcinoma in Slovenia. (23412351)
2012
12
HER2/neu gene amplification and protein overexpression in gastric and gastroesophageal junction adenocarcinoma: a review of histopathology, diagnostic testing, and clinical implications. (22646280)
2012
13
Relationship between gastroesophageal junction adenocarcinoma and Helicobacter pylori infection in Japan. (22472851)
2012
14
Clinicopathologic characteristics and survival outcomes of patients with advanced esophageal, gastroesophageal junction, and gastric adenocarcinoma: a single-institution experience. (23300355)
2012
15
Preoperative chemotherapy with cisplatin and docetaxel followed by surgery and clip-oriented postoperative chemoradiation in patients with localized gastric or gastroesophageal junction adenocarcinoma: results from a phase II feasibility study. (21063792)
2011
16
A multicenter, phase II study of bortezomib (PS-341) in patients with unresectable or metastatic gastric and gastroesophageal junction adenocarcinoma. (20574790)
2011
17
Gastroesophageal junction adenocarcinoma of young patients who underwent curative surgery: a comparative analysis with older group. (21264755)
2011
18
Adjuvant bi-weekly combination of cisplatin, infusional 5-fluorouracil and folinic acid followed by concomitant chemoradiotherapy with infusional fluorouracil for high risk operated gastric and gastroesophageal junction adenocarcinoma. (21338186)
2010
19
Phase II study of sorafenib in combination with docetaxel and cisplatin in the treatment of metastatic or advanced gastric and gastroesophageal junction adenocarcinoma: ECOG 5203. (20458043)
2010
20
Phase II study of epirubicin, oxaliplatin and docetaxel combination in metastatic gastric or gastroesophageal junction adenocarcinoma. (19267943)
2009
21
Array comparative genomic hybridization, expression array, and protein analysis of critical regions on chromosome arms 1q, 7q, and 8p in adenocarcinomas of the gastroesophageal junction. (19167610)
2009
22
Predictive value of initial PET-SUVmax in patients with locally advanced esophageal and gastroesophageal junction adenocarcinoma. (19487968)
2009
23
Transition in biology and philosophy in the treatment of gastroesophageal junction adenocarcinoma. (19139425)
2009
24
Polymeric immunoglobulin receptor-negative tumors represent a more aggressive type of adenocarcinomas of distal esophagus and gastroesophageal junction. (18684029)
2008
25
Is radiation therapy needed in the treatment of gastroesophageal junction adenocarcinoma? (19343142)
2008
26
Molecular dissection of the chromosome band 7q21 amplicon in gastroesophageal junction adenocarcinomas identifies cyclin-dependent kinase 6 at both genomic and protein expression levels. (18438866)
2008
27
Anti-Yo-associated paraneoplastic cerebellar degeneration in a man with adenocarcinoma of the gastroesophageal junction. (17785986)
2007
28
The prevalence of Helicobacter pylori infection and the status of gastric acid secretion in patients with gastroesophageal junction adenocarcinoma in Japan. (17450443)
2007
29
Interleukin-1 genetic polymorphisms and their relationship to the cancer anorexia/weight loss syndrome in metastatic gastric and gastroesophageal junction adenocarcinoma. (17265786)
2007
30
Molecular prognostic factors in adenocarcinoma of the esophagus and gastroesophageal junction. (17122988)
2007
31
New proposal for postsurgery pathologic staging of esophageal or gastroesophageal junction adenocarcinoma: why bother? (17327615)
2007
32
Phase II trial of erlotinib in gastroesophageal junction and gastric adenocarcinomas: SWOG 0127. (17050876)
2006
33
Familiality in Barrett's esophagus, adenocarcinoma of the esophagus, and adenocarcinoma of the gastroesophageal junction. (16985029)
2006
34
Multicentre phase II pharmacokinetic and pharmacodynamic study of OSI-7904L in previously untreated patients with advanced gastric or gastroesophageal junction adenocarcinoma. (16880795)
2006
35
Multicenter phase II study of irinotecan, cisplatin, and bevacizumab in patients with metastatic gastric or gastroesophageal junction adenocarcinoma. (17114652)
2006
36
A multi-center phase II study of sequential paclitaxel and bryostatin-1 (NSC 339555) in patients with untreated, advanced gastric or gastroesophageal junction adenocarcinoma. (16683077)
2006
37
Preservation of gastric acid secretion may be important for the development of gastroesophageal junction adenocarcinoma in Japanese people, irrespective of the H. pylori infection status. (16573782)
2006
38
Gastroesophageal junction adenocarcinoma: what are the factors influencing long-term survival? (16845860)
2006
39
Multicenter phase II trial of S-1 plus cisplatin in patients with untreated advanced gastric or gastroesophageal junction adenocarcinoma. (16446338)
2006
40
Reduced p120ctn expression correlates with poor survival in patients with adenocarcinoma of the gastroesophageal junction. (16231374)
2005
41
Significance and prognostic value of lysosomal enzyme activities measured in surgically operated adenocarcinomas of the gastroesophageal junction and squamous cell carcinomas of the lower third of esophagus. (16270380)
2005
42
Comparison of the clinical and histological characteristics and survival of distal esophageal-gastroesophageal junction adenocarcinoma in patients with and without barrett mucosa. (15967904)
2005
43
Neuroendocrine in Barrett's mucosa and adenocarcinomas of the gastroesophageal junction. (15173916)
2004
44
Molecular genetic analysis of the von Hippel-Lindau and human peroxisome proliferator-activated receptor gamma tumor-suppressor genes in adenocarcinomas of the gastroesophageal junction. (11745495)
2001
45
Gastroesophageal junction adenocarcinoma. (12057146)
2000
46
Comparative genomic hybridization of cancer of the gastroesophageal junction: deletion of 14Q31-32.1 discriminates between esophageal (Barrett's) and gastric cardia adenocarcinomas. (9973227)
1999
47
Paclitaxel and concurrent radiation therapy for locally advanced adenocarcinomas of the pancreas, stomach, and gastroesophageal junction. (10210540)
1999
48
A phase II study of 5-fluorouracil, leucovorin, adriamycin, and cisplatin (FLAP) for metastatic gastric and gastroesophageal junction adenocarcinoma. A Penn Cancer Clinical Trial Group and Roswell Park Cancer Institute Community Oncology Research Program Trial. (9167745)
1997
49
Rapid progression of gastroesophageal junction adenocarcinoma after liver transplantation. (9013353)
1997
50
Intensive preoperative chemotherapy with colony-stimulating factor for resectable adenocarcinoma of the esophagus or gastroesophageal junction. (8418237)
1993

Genetic Variations for Gastroesophageal Junction Adenocarcinoma

Expression for genes affiliated with Gastroesophageal Junction Adenocarcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Gastroesophageal Junction Adenocarcinoma

Search GEO for disease gene expression data for Gastroesophageal Junction Adenocarcinoma.

Pathways for genes affiliated with Gastroesophageal Junction Adenocarcinoma

Sources:
60Tocris Bioscience, 54Reactome, 52QIAGEN, 38NCBI BioSystems Database, 30KEGG
See all sources

Pathways related to Gastroesophageal Junction Adenocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.7PTK2
2
Hide members
9.3ERBB2, PTK2
3
Hide members
9.3ERBB2, PTK2
4
Hide members
9.0PTK2, CDK6
5
Hide members
8.7CDK6, PTK2, ERBB2

Compounds for genes affiliated with Gastroesophageal Junction Adenocarcinoma

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 24HMDB, 2BitterDB
See all sources

Compounds related to Gastroesophageal Junction Adenocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1glutamate4510.6PICK1
2capecitabine45 50 1112.1ERBB2, TYMS
3vegf4510.1IL1B, TYMS
4levamisole45 1111.1ERBB2, TYMS
55-methylthioadenosine4510.1ERBB2, TYMS
6vinorelbine45 1111.0ERBB2, TYMS
7risedronate45 60 50 29 1114.0IL1B, TYMS
8taxane4510.0ERBB2, TYMS
9n-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide45 1111.0ERBB2, DYT10
10pd153035459.9ERBB2, DYT10
11ag-126459.9DYT10, IL1B
12n,n-dimethylsphingosine45 6010.9DYT10, IL1B
13mezerein459.9IL1B, DYT10
14dexamethasone45 50 29 1112.9PTK2
15aacocf3459.9DYT10, IL1B
16staurosporin459.8IL1B, DYT10
17cetuximab45 50 1111.8ERBB2, TYMS
18resveratrol45 60 11 2412.7ERBB2, PTK2
19polymyxin b459.6DYT10, IL1B
20methotrexate45 50 1111.6TYMS, IL1B, ERBB2
21gefitinib45 50 1111.5TYMS, CDK6, ERBB2
22phorbol 12,13-dibutyrate459.5DYT10, CDK6
2317-(allylamino)-17-demethoxygeldanamycin459.5ERBB2, CDK6
24valine459.5TYMS, CDK6, ERBB2
25docetaxel45 50 60 1112.3ERBB2, PTK2, TYMS
26calpeptin45 6010.3DYT10, PTK2
27quercetin45 60 11 2412.2PTK2, IL1B, TYMS
285fluorouracil459.2TYMS, PTK2, ERBB2
29ag 1478459.2ERBB2, PTK2, DYT10
30curcumin459.2ERBB2, PTK2, IL1B
31carbachol45 29 1111.1DYT10, PTK2, ERBB2
32ro 31 8220459.1PTK2, IL1B, DYT10
33c2ceramide459.1DYT10, IL1B, PTK2
34etoposide45 50 60 1112.0ERBB2, PTK2, TYMS
35gnrh459.0ERBB2, PTK2, DYT10
36tgf beta1458.9PTK2, IL1B, CDK6
37rottlerin458.9DYT10, CDK6, PTK2
38bapta458.8PTK2, DYT10
39erbstatin458.8ERBB2, PTK2, IL1B, DYT10
40n acetylcysteine458.7ERBB2, PTK2, IL1B, DYT10
41genistein45 29 60 2 11 2413.7DYT10, IL1B, PTK2, ERBB2
42cisplatin45 50 60 1111.7TYMS, CDK6, PTK2, ERBB2
43arginine458.6EXT1, TYMS, PTK2, ERBB2
44sb 20358045 609.6DYT10, IL1B, PTK2
45rapamycin458.6DYT10, CDK6, PTK2, ERBB2
46cycloheximide458.4DYT10, TYMS, IL1B, PTK2, ERBB2
47tamoxifen45 50 29 1111.2ERBB2, PTK2, CDK6, TYMS, DYT10
48herbimycin a45 609.1DYT10, CDK6, IL1B, PTK2, ERBB2
49ly294002458.1DYT10, CDK6, IL1B, PTK2, ERBB2
50serine457.9DYT10, PICK1, TYMS, CDK6, PTK2, ERBB2

GO Terms for genes affiliated with Gastroesophageal Junction Adenocarcinoma

Sources:
16Gene Ontology
See all sources

Biological processes related to Gastroesophageal Junction Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell adhesionGO:0457859.0ERBB2, PTK2
2axon guidanceGO:0074118.9ERBB2, PTK2, EXT1
3positive regulation of protein phosphorylationGO:0019348.7ERBB2, PTK2, IL1B

Products for genes affiliated with Gastroesophageal Junction Adenocarcinoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gastroesophageal Junction Adenocarcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet