MCID: GST012
MIFTS: 38

Gastroesophageal Junction Adenocarcinoma malady

Gastrointestinal diseases, Cardiovascular diseases categories

Summaries for Gastroesophageal Junction Adenocarcinoma

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MalaCards based summary: Gastroesophageal Junction Adenocarcinoma, also known as adenocarcinoma of cardioesophageal junction, is related to adenocarcinoma and meningitis. An important gene associated with Gastroesophageal Junction Adenocarcinoma is TYMS (thymidylate synthetase), and among its related pathways are Alpha6-Beta4 Integrin Signaling Pathway and Agrin Interactions at Neuromuscular Junction. The compounds capecitabine and levamisole have been mentioned in the context of this disorder. Affiliated tissues include lymph node, brain and liver, and related mouse phenotype tumorigenesis.

Aliases & Classifications for Gastroesophageal Junction Adenocarcinoma

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Gastroesophageal Junction Adenocarcinoma, Aliases & Descriptions:

Name: Gastroesophageal Junction Adenocarcinoma 10
Adenocarcinoma of Cardioesophageal Junction 10 62
 
Adenocarcinoma of the Gastroesophageal Junction 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Cardiovascular diseases


External Ids:

Disease Ontology10 DOID:4944
NCIt40 C9296

Related Diseases for Gastroesophageal Junction Adenocarcinoma

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Diseases related to Gastroesophageal Junction Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 35)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.5TYMS, PTK2, ERBB2, CDK6
2meningitis30.3IL1B, PTK2
3esophagitis10.5
4h. pylori infection10.2
5biliary tract neoplasm10.0TYMS, ERBB2
6factor vii deficiency10.0TYMS, ERBB2
7toxic shock syndrome10.0IL1B, TYMS
8diarrhea10.0ERBB2, TYMS
9salivary gland adenoid cystic carcinoma10.0ERBB2, DYT10
10monocytic leukemia10.0IL1B, DYT10
11neutropenia10.0ERBB2, TYMS
12pulmonary fibrosis, idiopathic10.0IL1B, DYT10
13t-cell leukemia10.0CDK6, DYT10, TYMS
14osteosarcoma, somatic10.0TYMS, DYT10, EXT1
15leukemia, acute lymphoblastic10.0TYMS, DYT10, CDK6
16cervical cancer, somatic10.0ERBB2, PTK2, TYMS
17gastric cancer, somatic10.0ERBB2, IL1B, TYMS
18ovarian cancer, somatic10.0TYMS, PTK2, ERBB2
19endometrial cancer10.0CDK6, ERBB2, PTK2
20colon adenocarcinoma10.0DYT10, PTK2, TYMS
21cholangiocarcinoma10.0ERBB2, DYT10, PTK2
22sarcoma10.0PTK2, EXT1, CDK6
23lung cancer susceptibility 310.0PTK2, DYT10, ERBB2
24colorectal cancer10.0DYT10, PTK2, TYMS
25astrocytoma10.0PTK2, IL1B, DYT10
26squamous cell carcinoma, head and neck10.0TYMS, PTK2, ERBB2, CDK6
27lung cancer10.0CDK6, ERBB2, PTK2, TYMS
28pancreatic cancer10.0TYMS, PTK2, ERBB2, CDK6
29tongue squamous cell carcinoma10.0CDK6, ERBB2, PTK2, TYMS
30breast cancer10.0TYMS, PTK2, DYT10, ERBB2
31glioblastoma9.9PTK2, DYT10, ERBB2, CDK6
32atherosclerosis9.9PTK2, IL1B, DYT10
33prostate cancer9.9CDK6, ERBB2, DYT10, PTK2
34retinoblastoma9.9TYMS, PTK2, DYT10, ERBB2, CDK6
35leukemia9.9TYMS, PTK2, IL1B, DYT10, CDK6

Graphical network of the top 20 diseases related to Gastroesophageal Junction Adenocarcinoma:



Diseases related to gastroesophageal junction adenocarcinoma

Symptoms for Gastroesophageal Junction Adenocarcinoma

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Drugs & Therapeutics for Gastroesophageal Junction Adenocarcinoma

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Drug clinical trials:

Search ClinicalTrials for Gastroesophageal Junction Adenocarcinoma

Search NIH Clinical Center for Gastroesophageal Junction Adenocarcinoma

Genetic Tests for Gastroesophageal Junction Adenocarcinoma

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Anatomical Context for Gastroesophageal Junction Adenocarcinoma

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MalaCards organs/tissues related to Gastroesophageal Junction Adenocarcinoma:

33
Lymph node, Brain, Liver, Testes

Animal Models for Gastroesophageal Junction Adenocarcinoma or affiliated genes

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MGI Mouse Phenotypes related to Gastroesophageal Junction Adenocarcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.0CDK6, EXT1, ERBB2, IL1B, PTK2

Publications for Gastroesophageal Junction Adenocarcinoma

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Articles related to Gastroesophageal Junction Adenocarcinoma:

(show all 48)
idTitleAuthorsYear
1
Incidence of brain metastases in HER2+ gastric or gastroesophageal junction adenocarcinoma. (25753188)
2015
2
Personalizing risk stratification by addition of PAK1 expression to TNM staging: Improving the accuracy of clinical decision for gastroesophageal junction adenocarcinoma. (25159681)
2014
3
Combined neutron brachytherapy with external beam radiation in patients with inoperable gastroesophageal junction adenocarcinoma. (25296599)
2014
4
The safety and usefulness of neutron brachytherapy and external beam radiation in the treatment of patients with gastroesophageal junction adenocarcinoma with or without chemotherapy. (24774780)
2014
5
Prognostic importance and therapeutic implications of PAK1, a drugable protein kinase, in gastroesophageal junction adenocarcinoma. (24236193)
2013
6
Meningeal carcinomatosis: a metastasis from gastroesophageal junction adenocarcinoma. (24454393)
2013
7
Results of docetaxel plus oxaliplatin (DOCOX) A+ cetuximab in patients with metastatic gastric and/or gastroesophageal junction adenocarcinoma: results of a randomised Phase 2 study. (23747051)
2013
8
Snail1 correlates with patient outcomes in E-cadherin-preserved gastroesophageal junction adenocarcinoma. (24356933)
2013
9
The metastasis-associated gene MTA3, a component of the Mi-2/NuRD transcriptional repression complex, predicts prognosis of gastroesophageal junction adenocarcinoma. (23671646)
2013
10
Distant lymph node metastases in gastroesophageal junction adenocarcinoma: impact of endoscopic ultrasound-guided fine-needle aspiration. (24949383)
2013
11
HER2 expression and relevant clinicopathological features in gastric and gastroesophageal junction adenocarcinoma in a Chinese population. (23656792)
2013
12
Gastroesophageal junction adenocarcinoma metastasizing to gingiva. (23776844)
2013
13
Reconstructive options for gastroesophageal junction adenocarcinoma after Roux-en-Y gastric bypass. (23988286)
2013
14
A phase II study of neoadjuvant docetaxel, oxaliplatin, and S-1 (DOS) chemotherapy followed by surgery and adjuvant S-1 chemotherapy in potentially resectable gastric or gastroesophageal junction adenocarcinoma. (23921575)
2013
15
Unanswered questions in the management of gastroesophageal junction adenocarcinoma. (23714486)
2013
16
The incidence and prognostic value of HER2 overexpression and cyclin D1 expression in patients with gastric or gastroesophageal junction adenocarcinoma in Israel. (23420289)
2013
17
HER2 expression in gastric and gastroesophageal junction adenocarcinoma in a US population: clinicopathologic analysis with proposed approach to HER2 assessment. (21617522)
2012
18
Postoperative intraperitoneal 5-fluoro-2'-deoxyuridine added to chemoradiation in patients curatively resected (R0) for locally advanced gastric and gastroesophageal junction adenocarcinoma. (21769462)
2012
19
Results of postoperative radiochemotherapy of the patients with resectable gastroesophageal junction adenocarcinoma in Slovenia. (23412351)
2012
20
HER2/neu gene amplification and protein overexpression in gastric and gastroesophageal junction adenocarcinoma: a review of histopathology, diagnostic testing, and clinical implications. (22646280)
2012
21
Relationship between gastroesophageal junction adenocarcinoma and Helicobacter pylori infection in Japan. (22472851)
2012
22
Preoperative chemotherapy with cisplatin and docetaxel followed by surgery and clip-oriented postoperative chemoradiation in patients with localized gastric or gastroesophageal junction adenocarcinoma: results from a phase II feasibility study. (21063792)
2011
23
A multicenter, phase II study of bortezomib (PS-341) in patients with unresectable or metastatic gastric and gastroesophageal junction adenocarcinoma. (20574790)
2011
24
Adjuvant bi-weekly combination of cisplatin, infusional 5-fluorouracil and folinic acid followed by concomitant chemoradiotherapy with infusional fluorouracil for high risk operated gastric and gastroesophageal junction adenocarcinoma. (21338186)
2010
25
Phase II study of sorafenib in combination with docetaxel and cisplatin in the treatment of metastatic or advanced gastric and gastroesophageal junction adenocarcinoma: ECOG 5203. (20458043)
2010
26
Phase II study of epirubicin, oxaliplatin and docetaxel combination in metastatic gastric or gastroesophageal junction adenocarcinoma. (19267943)
2009
27
Predictive value of initial PET-SUVmax in patients with locally advanced esophageal and gastroesophageal junction adenocarcinoma. (19487968)
2009
28
Transition in biology and philosophy in the treatment of gastroesophageal junction adenocarcinoma. (19139425)
2009
29
Local recurrence following adjuvant chemotherapy without radiotherapy in completely resected stomach and gastroesophageal junction adenocarcinoma. (19443416)
2009
30
Is radiation therapy needed in the treatment of gastroesophageal junction adenocarcinoma? (19343142)
2008
31
Molecular dissection of the chromosome band 7q21 amplicon in gastroesophageal junction adenocarcinomas identifies cyclin-dependent kinase 6 at both genomic and protein expression levels. (18438866)
2008
32
Irinotecan, docetaxel and oxaliplatin combination in metastatic gastric or gastroesophageal junction adenocarcinoma. (17667920)
2007
33
High-resolution array comparative genomic hybridization of chromosome 8q: evaluation of putative progression markers for gastroesophageal junction adenocarcinomas. (18000363)
2007
34
Lymph node involvement in advanced gastroesophageal junction adenocarcinoma. (17662776)
2007
35
The prevalence of Helicobacter pylori infection and the status of gastric acid secretion in patients with gastroesophageal junction adenocarcinoma in Japan. (17450443)
2007
36
Interleukin-1 genetic polymorphisms and their relationship to the cancer anorexia/weight loss syndrome in metastatic gastric and gastroesophageal junction adenocarcinoma. (17265786)
2007
37
New proposal for postsurgery pathologic staging of esophageal or gastroesophageal junction adenocarcinoma: why bother? (17327615)
2007
38
Multicentre phase II pharmacokinetic and pharmacodynamic study of OSI-7904L in previously untreated patients with advanced gastric or gastroesophageal junction adenocarcinoma. (16880795)
2006
39
Multicenter phase II study of irinotecan, cisplatin, and bevacizumab in patients with metastatic gastric or gastroesophageal junction adenocarcinoma. (17114652)
2006
40
A multi-center phase II study of sequential paclitaxel and bryostatin-1 (NSC 339555) in patients with untreated, advanced gastric or gastroesophageal junction adenocarcinoma. (16683077)
2006
41
Preservation of gastric acid secretion may be important for the development of gastroesophageal junction adenocarcinoma in Japanese people, irrespective of the H. pylori infection status. (16573782)
2006
42
Gastroesophageal junction adenocarcinoma: what are the factors influencing long-term survival? (16845860)
2006
43
Multicenter phase II trial of S-1 plus cisplatin in patients with untreated advanced gastric or gastroesophageal junction adenocarcinoma. (16446338)
2006
44
Comparison of the clinical and histological characteristics and survival of distal esophageal-gastroesophageal junction adenocarcinoma in patients with and without barrett mucosa. (15967904)
2005
45
Metastatic gastroesophageal junction adenocarcinoma to the extraocular muscles. (12578774)
2003
46
Gastroesophageal junction adenocarcinoma. (12057146)
2000
47
A phase II study of 5-fluorouracil, leucovorin, adriamycin, and cisplatin (FLAP) for metastatic gastric and gastroesophageal junction adenocarcinoma. A Penn Cancer Clinical Trial Group and Roswell Park Cancer Institute Community Oncology Research Program Trial. (9167745)
1997
48
Rapid progression of gastroesophageal junction adenocarcinoma after liver transplantation. (9013353)
1997

Variations for Gastroesophageal Junction Adenocarcinoma

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Expression for genes affiliated with Gastroesophageal Junction Adenocarcinoma

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Search GEO for disease gene expression data for Gastroesophageal Junction Adenocarcinoma.

Pathways for genes affiliated with Gastroesophageal Junction Adenocarcinoma

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Pathways related to Gastroesophageal Junction Adenocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3ERBB2, PTK2
29.3PTK2, ERBB2
39.1CDK6, PTK2
4
Show member pathways
8.9PTK2, IL1B, ERBB2
5
Show member pathways
8.9ERBB2, IL1B, PTK2
68.8PTK2, ERBB2, CDK6
7
Show member pathways
Integrin-mediated cell adhesion38
Focal Adhesion38
8.8CDK6, ERBB2, PTK2
8
Show member pathways
8.4CDK6, ERBB2, IL1B, PTK2

Compounds for genes affiliated with Gastroesophageal Junction Adenocarcinoma

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Compounds related to Gastroesophageal Junction Adenocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1capecitabine45 51 1312.2ERBB2, TYMS
2levamisole45 1311.1TYMS, ERBB2
3risedronate45 51 30 61 1314.1TYMS, IL1B
45-methylthioadenosine4510.1ERBB2, TYMS
5vinorelbine45 51 1312.0TYMS, ERBB2
6taxane4510.0TYMS, ERBB2
7n-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide45 1310.9DYT10, ERBB2
8ag-126459.8IL1B, DYT10
9n,n-dimethylsphingosine45 6110.8IL1B, DYT10
10mezerein459.8IL1B, DYT10
11pd153035459.8DYT10, ERBB2
12cetuximab45 51 1311.8ERBB2, TYMS
13aacocf3459.8DYT10, IL1B
14gefitinib45 51 1311.7CDK6, ERBB2, TYMS
15methotrexate51 45 1311.7TYMS, IL1B, ERBB2
16staurosporin459.7DYT10, IL1B
17valine459.6CDK6, ERBB2, TYMS
18docetaxel45 51 61 1312.4ERBB2, PTK2, TYMS
19polymyxin b459.3DYT10, IL1B
20phorbol 12,13-dibutyrate459.3CDK6, DYT10
21quercetin45 61 26 1312.3IL1B, PTK2, TYMS
225fluorouracil459.3ERBB2, PTK2, TYMS
23curcumin459.3PTK2, IL1B, ERBB2
24resveratrol45 61 26 1312.2PTK2, ERBB2, CDK6
25egcg459.2CDK6, ERBB2, PTK2
26etoposide45 51 61 1312.1ERBB2, PTK2, TYMS
27ag 1478459.1PTK2, DYT10, ERBB2
28tgf beta1459.1CDK6, IL1B, PTK2
29carbachol45 30 1311.1PTK2, DYT10, ERBB2
30ro 31 8220459.1PTK2, IL1B, DYT10
31c2ceramide459.1DYT10, IL1B, PTK2
32gnrh459.0ERBB2, DYT10, PTK2
33rottlerin458.9CDK6, DYT10, PTK2
34butyrate458.9TYMS, PTK2, CDK6
35cisplatin45 51 61 1311.9CDK6, ERBB2, PTK2, TYMS
36arginine458.9TYMS, PTK2, ERBB2, EXT1
37sb 20358045 619.7DYT10, IL1B, PTK2
38calpeptin45 619.7DYT10, PTK2
39erbstatin458.7ERBB2, DYT10, IL1B, PTK2
40n acetylcysteine458.7PTK2, IL1B, DYT10, ERBB2
41dexamethasone45 51 30 1311.7CDK6, ERBB2, IL1B, PTK2
42genistein45 30 61 3 26 1313.7ERBB2, DYT10, IL1B, PTK2
43rapamycin458.6PTK2, DYT10, ERBB2, CDK6
44glutamate458.6TYMS, PTK2, DYT10, ERBB2
45cycloheximide458.4ERBB2, DYT10, IL1B, PTK2, TYMS
46vegf458.4ERBB2, DYT10, IL1B, PTK2, TYMS
47tamoxifen45 51 30 1311.3TYMS, PTK2, DYT10, ERBB2, CDK6
48herbimycin a45 619.2PTK2, IL1B, DYT10, ERBB2, CDK6
49ly294002458.2CDK6, ERBB2, DYT10, IL1B, PTK2
50serine458.2TYMS, PTK2, DYT10, ERBB2, CDK6

GO Terms for genes affiliated with Gastroesophageal Junction Adenocarcinoma

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Biological processes related to Gastroesophageal Junction Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axon guidanceGO:00074118.9EXT1, ERBB2, PTK2
2positive regulation of protein phosphorylationGO:00019348.6ERBB2, IL1B, PTK2

Products for genes affiliated with Gastroesophageal Junction Adenocarcinoma

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Sources for Gastroesophageal Junction Adenocarcinoma

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet