MCID: GST012
MIFTS: 38

Gastroesophageal Junction Adenocarcinoma malady

Gastrointestinal diseases, Cancer diseases, Cardiovascular diseases categories

Summaries for Gastroesophageal Junction Adenocarcinoma

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34MalaCards
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MalaCards: Gastroesophageal Junction Adenocarcinoma, also known as adenocarcinoma of the gastroesophageal junction, is related to adenocarcinoma and esophagitis. An important gene associated with Gastroesophageal Junction Adenocarcinoma is TYMS (thymidylate synthetase), and among its related pathways are Alpha6-Beta4 Integrin Signaling Pathway and Agrin Interactions at Neuromuscular Junction. The compounds capecitabine and levamisole have been mentioned in the context of this disorder. Affiliated tissues include lymph node, liver and testes, and related mouse phenotype tumorigenesis.

Aliases & Classifications for Gastroesophageal Junction Adenocarcinoma

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9Disease Ontology, 63UMLS, 41NCIt
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Classifications:



Aliases & Descriptions:

gastroesophageal junction adenocarcinoma 9
adenocarcinoma of the gastroesophageal junction 63
adenocarcinoma of cardioesophageal junction 9


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Disease Ontology9 DOID:4944
NCIt41 C9296

Related Diseases for Gastroesophageal Junction Adenocarcinoma

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18GeneCards, 19GeneDecks
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Diseases related to Gastroesophageal Junction Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 36)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.4TYMS, PTK2, ERBB2, CDK6
2esophagitis10.5
3biliary tract neoplasm10.1TYMS, ERBB2
4factor vii deficiency10.1TYMS, ERBB2
5toxic shock syndrome10.1IL1B, TYMS
6diarrhea10.0ERBB2, TYMS
7adenoid cystic carcinoma10.0ERBB2, DYT10
8monocytic leukemia10.0IL1B, DYT10
9neutropenia10.0ERBB2, TYMS
10idiopathic pulmonary fibrosis10.0IL1B, DYT10
11meningitis10.0IL1B, PTK2
12t-cell leukemia10.0CDK6, DYT10, TYMS
13osteosarcoma10.0TYMS, DYT10, EXT1
14acute lymphocytic leukemia10.0TYMS, DYT10, CDK6
15cervical cancer10.0ERBB2, PTK2, TYMS
16stomach cancer10.0ERBB2, IL1B, TYMS
17colorectal cancer10.0ERBB2, PTK2, TYMS
18ovarian cancer10.0TYMS, PTK2, ERBB2
19endometrial carcinoma10.0CDK6, ERBB2, PTK2
20colon adenocarcinoma10.0DYT10, PTK2, TYMS
21cholangiocarcinoma10.0ERBB2, DYT10, PTK2
22sarcoma10.0PTK2, EXT1, CDK6
23lung adenocarcinoma10.0PTK2, DYT10, ERBB2
24colon cancer9.9DYT10, PTK2, TYMS
25astrocytoma9.9PTK2, IL1B, DYT10
26squamous cell carcinoma of the head and neck9.9TYMS, PTK2, ERBB2, CDK6
27non-small cell lung carcinoma9.9CDK6, ERBB2, PTK2, TYMS
28pancreatic cancer9.9TYMS, PTK2, ERBB2, CDK6
29tongue squamous cell carcinoma9.9CDK6, ERBB2, PTK2, TYMS
30lung cancer9.9ERBB2, DYT10, PTK2, TYMS
31breast cancer9.9TYMS, PTK2, DYT10, ERBB2
32glioblastoma multiforme9.9PTK2, DYT10, ERBB2, CDK6
33atherosclerosis9.9PTK2, IL1B, DYT10
34prostate cancer9.9CDK6, ERBB2, DYT10, PTK2
35retinoblastoma9.9TYMS, PTK2, DYT10, ERBB2, CDK6
36leukemia9.9TYMS, PTK2, IL1B, DYT10, CDK6

Graphical network of the top 20 diseases related to Gastroesophageal Junction Adenocarcinoma:



Diseases related to gastroesophageal junction adenocarcinoma

Symptoms for Gastroesophageal Junction Adenocarcinoma

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Drugs & Therapeutics for Gastroesophageal Junction Adenocarcinoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Gastroesophageal Junction Adenocarcinoma

Drug clinical trials:

Search ClinicalTrials for Gastroesophageal Junction Adenocarcinoma

Search NIH Clinical Center for Gastroesophageal Junction Adenocarcinoma

Search CenterWatch for Gastroesophageal Junction Adenocarcinoma

Genetic Tests for Gastroesophageal Junction Adenocarcinoma

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Anatomical Context for Gastroesophageal Junction Adenocarcinoma

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34MalaCards
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MalaCards organs/tissues related to Gastroesophageal Junction Adenocarcinoma:

34
Lymph node, Liver, Testes

Animal Models for Gastroesophageal Junction Adenocarcinoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Gastroesophageal Junction Adenocarcinoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.0CDK6, EXT1, ERBB2, IL1B, PTK2

Publications for Gastroesophageal Junction Adenocarcinoma

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53PubMed
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Articles related to Gastroesophageal Junction Adenocarcinoma:

(show all 42)
idTitleAuthorsYear
1
Prognostic importance and therapeutic implications of PAK1, a drugable protein kinase, in gastroesophageal junction adenocarcinoma. (24236193)
2013
2
Results of docetaxel plus oxaliplatin (DOCOX) A+ cetuximab in patients with metastatic gastric and/or gastroesophageal junction adenocarcinoma: results of a randomised Phase 2 study. (23747051)
2013
3
Snail1 correlates with patient outcomes in E-cadherin-preserved gastroesophageal junction adenocarcinoma. (24356933)
2013
4
The metastasis-associated gene MTA3, a component of the Mi-2/NuRD transcriptional repression complex, predicts prognosis of gastroesophageal junction adenocarcinoma. (23671646)
2013
5
HER2 expression and relevant clinicopathological features in gastric and gastroesophageal junction adenocarcinoma in a Chinese population. (23656792)
2013
6
Gastroesophageal junction adenocarcinoma metastasizing to gingiva. (23776844)
2013
7
Reconstructive options for gastroesophageal junction adenocarcinoma after Roux-en-Y gastric bypass. (23988286)
2013
8
A phase II study of neoadjuvant docetaxel, oxaliplatin, and S-1 (DOS) chemotherapy followed by surgery and adjuvant S-1 chemotherapy in potentially resectable gastric or gastroesophageal junction adenocarcinoma. (23921575)
2013
9
Unanswered questions in the management of gastroesophageal junction adenocarcinoma. (23714486)
2013
10
The incidence and prognostic value of HER2 overexpression and cyclin D1 expression in patients with gastric or gastroesophageal junction adenocarcinoma in Israel. (23420289)
2013
11
HER2 expression in gastric and gastroesophageal junction adenocarcinoma in a US population: clinicopathologic analysis with proposed approach to HER2 assessment. (21617522)
2012
12
Postoperative intraperitoneal 5-fluoro-2'-deoxyuridine added to chemoradiation in patients curatively resected (R0) for locally advanced gastric and gastroesophageal junction adenocarcinoma. (21769462)
2012
13
Results of postoperative radiochemotherapy of the patients with resectable gastroesophageal junction adenocarcinoma in Slovenia. (23412351)
2012
14
HER2/neu gene amplification and protein overexpression in gastric and gastroesophageal junction adenocarcinoma: a review of histopathology, diagnostic testing, and clinical implications. (22646280)
2012
15
Relationship between gastroesophageal junction adenocarcinoma and Helicobacter pylori infection in Japan. (22472851)
2012
16
Preoperative chemotherapy with cisplatin and docetaxel followed by surgery and clip-oriented postoperative chemoradiation in patients with localized gastric or gastroesophageal junction adenocarcinoma: results from a phase II feasibility study. (21063792)
2011
17
A multicenter, phase II study of bortezomib (PS-341) in patients with unresectable or metastatic gastric and gastroesophageal junction adenocarcinoma. (20574790)
2011
18
Gastroesophageal junction adenocarcinoma of young patients who underwent curative surgery: a comparative analysis with older group. (21264755)
2011
19
Adjuvant bi-weekly combination of cisplatin, infusional 5-fluorouracil and folinic acid followed by concomitant chemoradiotherapy with infusional fluorouracil for high risk operated gastric and gastroesophageal junction adenocarcinoma. (21338186)
2010
20
Phase II study of sorafenib in combination with docetaxel and cisplatin in the treatment of metastatic or advanced gastric and gastroesophageal junction adenocarcinoma: ECOG 5203. (20458043)
2010
21
Phase II study of epirubicin, oxaliplatin and docetaxel combination in metastatic gastric or gastroesophageal junction adenocarcinoma. (19267943)
2009
22
Predictive value of initial PET-SUVmax in patients with locally advanced esophageal and gastroesophageal junction adenocarcinoma. (19487968)
2009
23
Transition in biology and philosophy in the treatment of gastroesophageal junction adenocarcinoma. (19139425)
2009
24
Local recurrence following adjuvant chemotherapy without radiotherapy in completely resected stomach and gastroesophageal junction adenocarcinoma. (19443416)
2009
25
Is radiation therapy needed in the treatment of gastroesophageal junction adenocarcinoma? (19343142)
2008
26
Molecular dissection of the chromosome band 7q21 amplicon in gastroesophageal junction adenocarcinomas identifies cyclin-dependent kinase 6 at both genomic and protein expression levels. (18438866)
2008
27
Irinotecan, docetaxel and oxaliplatin combination in metastatic gastric or gastroesophageal junction adenocarcinoma. (17667920)
2007
28
High-resolution array comparative genomic hybridization of chromosome 8q: evaluation of putative progression markers for gastroesophageal junction adenocarcinomas. (18000363)
2007
29
Lymph node involvement in advanced gastroesophageal junction adenocarcinoma. (17662776)
2007
30
The prevalence of Helicobacter pylori infection and the status of gastric acid secretion in patients with gastroesophageal junction adenocarcinoma in Japan. (17450443)
2007
31
Interleukin-1 genetic polymorphisms and their relationship to the cancer anorexia/weight loss syndrome in metastatic gastric and gastroesophageal junction adenocarcinoma. (17265786)
2007
32
Phase II study of cetuximab in combination with FOLFIRI in patients with untreated advanced gastric or gastroesophageal junction adenocarcinoma (FOLCETUX study). (17164226)
2007
33
New proposal for postsurgery pathologic staging of esophageal or gastroesophageal junction adenocarcinoma: why bother? (17327615)
2007
34
Multicentre phase II pharmacokinetic and pharmacodynamic study of OSI-7904L in previously untreated patients with advanced gastric or gastroesophageal junction adenocarcinoma. (16880795)
2006
35
Multicenter phase II study of irinotecan, cisplatin, and bevacizumab in patients with metastatic gastric or gastroesophageal junction adenocarcinoma. (17114652)
2006
36
A multi-center phase II study of sequential paclitaxel and bryostatin-1 (NSC 339555) in patients with untreated, advanced gastric or gastroesophageal junction adenocarcinoma. (16683077)
2006
37
Gastroesophageal junction adenocarcinoma: what are the factors influencing long-term survival? (16845860)
2006
38
Multicenter phase II trial of S-1 plus cisplatin in patients with untreated advanced gastric or gastroesophageal junction adenocarcinoma. (16446338)
2006
39
Comparison of the clinical and histological characteristics and survival of distal esophageal-gastroesophageal junction adenocarcinoma in patients with and without barrett mucosa. (15967904)
2005
40
Metastatic gastroesophageal junction adenocarcinoma to the extraocular muscles. (12578774)
2003
41
A phase II study of 5-fluorouracil, leucovorin, adriamycin, and cisplatin (FLAP) for metastatic gastric and gastroesophageal junction adenocarcinoma. A Penn Cancer Clinical Trial Group and Roswell Park Cancer Institute Community Oncology Research Program Trial. (9167745)
1997
42
Rapid progression of gastroesophageal junction adenocarcinoma after liver transplantation. (9013353)
1997

Variations for Gastroesophageal Junction Adenocarcinoma

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Expression for genes affiliated with Gastroesophageal Junction Adenocarcinoma

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gastroesophageal Junction Adenocarcinoma

Search GEO for disease gene expression data for Gastroesophageal Junction Adenocarcinoma.

Pathways for genes affiliated with Gastroesophageal Junction Adenocarcinoma

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 54QIAGEN, 31KEGG, 62Tocris Bioscience
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Pathways related to Gastroesophageal Junction Adenocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3ERBB2, PTK2
29.3PTK2, ERBB2
39.1CDK6, PTK2
4
Show member pathways
8.9PTK2, IL1B, ERBB2
5
Show member pathways
8.9ERBB2, IL1B, PTK2
68.8PTK2, ERBB2, CDK6
7
Show member pathways
Integrin-mediated cell adhesion39
Focal Adhesion39
8.8CDK6, ERBB2, PTK2
8
Show member pathways
8.4CDK6, ERBB2, IL1B, PTK2

Compounds for genes affiliated with Gastroesophageal Junction Adenocarcinoma

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 30IUPHAR, 62Tocris Bioscience, 25HMDB, 3BitterDB
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Compounds related to Gastroesophageal Junction Adenocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1capecitabine46 52 1212.2ERBB2, TYMS
2levamisole46 1211.1TYMS, ERBB2
3risedronate46 52 30 62 1214.1TYMS, IL1B
45-methylthioadenosine4610.1ERBB2, TYMS
5vinorelbine46 52 1212.0TYMS, ERBB2
6taxane4610.0TYMS, ERBB2
7n-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide46 1210.9DYT10, ERBB2
8ag-126469.8IL1B, DYT10
9n,n-dimethylsphingosine46 6210.8IL1B, DYT10
10mezerein469.8IL1B, DYT10
11pd153035469.8DYT10, ERBB2
12cetuximab46 52 1211.8ERBB2, TYMS
13aacocf3469.8DYT10, IL1B
14gefitinib46 52 1211.7CDK6, ERBB2, TYMS
15methotrexate52 46 1211.7TYMS, IL1B, ERBB2
16staurosporin469.7DYT10, IL1B
17valine469.6CDK6, ERBB2, TYMS
18docetaxel46 52 62 1212.4ERBB2, PTK2, TYMS
19polymyxin b469.3DYT10, IL1B
20phorbol 12,13-dibutyrate469.3CDK6, DYT10
21quercetin46 62 25 1212.3IL1B, PTK2, TYMS
225fluorouracil469.3ERBB2, PTK2, TYMS
23curcumin469.3PTK2, IL1B, ERBB2
24resveratrol46 62 25 1212.2PTK2, ERBB2, CDK6
25egcg469.2CDK6, ERBB2, PTK2
26etoposide46 52 62 1212.1ERBB2, PTK2, TYMS
27ag 1478469.1PTK2, DYT10, ERBB2
28tgf beta1469.1CDK6, IL1B, PTK2
29carbachol46 30 1211.1PTK2, DYT10, ERBB2
30ro 31 8220469.1PTK2, IL1B, DYT10
31c2ceramide469.1DYT10, IL1B, PTK2
32gnrh469.0ERBB2, DYT10, PTK2
33rottlerin468.9CDK6, DYT10, PTK2
34butyrate468.9TYMS, PTK2, CDK6
35cisplatin46 52 62 1211.9CDK6, ERBB2, PTK2, TYMS
36arginine468.9TYMS, PTK2, ERBB2, EXT1
37sb 20358046 629.7DYT10, IL1B, PTK2
38calpeptin46 629.7DYT10, PTK2
39erbstatin468.7ERBB2, DYT10, IL1B, PTK2
40n acetylcysteine468.7PTK2, IL1B, DYT10, ERBB2
41dexamethasone46 52 30 1211.7CDK6, ERBB2, IL1B, PTK2
42genistein46 30 62 3 25 1213.7ERBB2, DYT10, IL1B, PTK2
43rapamycin468.6PTK2, DYT10, ERBB2, CDK6
44glutamate468.6TYMS, PTK2, DYT10, ERBB2
45cycloheximide468.4ERBB2, DYT10, IL1B, PTK2, TYMS
46vegf468.4ERBB2, DYT10, IL1B, PTK2, TYMS
47tamoxifen46 52 30 1211.3TYMS, PTK2, DYT10, ERBB2, CDK6
48herbimycin a46 629.2PTK2, IL1B, DYT10, ERBB2, CDK6
49ly294002468.2CDK6, ERBB2, DYT10, IL1B, PTK2
50serine468.2TYMS, PTK2, DYT10, ERBB2, CDK6

GO Terms for genes affiliated with Gastroesophageal Junction Adenocarcinoma

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17Gene Ontology
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Biological processes related to Gastroesophageal Junction Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axon guidanceGO:0074118.9EXT1, ERBB2, PTK2
2positive regulation of protein phosphorylationGO:0019348.6ERBB2, IL1B, PTK2

Products for genes affiliated with Gastroesophageal Junction Adenocarcinoma

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Gastroesophageal Junction Adenocarcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet