MCID: GST012
MIFTS: 39

Gastroesophageal Junction Adenocarcinoma malady

Gastrointestinal diseases, Cardiovascular diseases categories

Summaries for Gastroesophageal Junction Adenocarcinoma

About this section
Sources:
32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Gastroesophageal Junction Adenocarcinoma, also known as adenocarcinoma of the gastroesophageal junction, is related to adenocarcinoma and squamous cell carcinoma. An important gene associated with Gastroesophageal Junction Adenocarcinoma is PICK1 (protein interacting with PRKCA 1), and among its related pathways are Apoptosis Pathway and Toll-like Receptor Pathway. The compounds glutamate and capecitabine have been mentioned in the context of this disorder. Affiliated tissues include lymph node, liver and pancreas, and related mouse phenotype tumorigenesis.

Aliases & Classifications for Gastroesophageal Junction Adenocarcinoma

About this section
Sources:
8Disease Ontology, 60UMLS, 39NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Cardiovascular diseases


Aliases & Descriptions:

gastroesophageal junction adenocarcinoma 8
adenocarcinoma of the gastroesophageal junction 60
adenocarcinoma of cardioesophageal junction 8


External Ids:

Disease Ontology8 DOID:4944
NCIt39 C9296

Related Diseases for Gastroesophageal Junction Adenocarcinoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Gastroesophageal Junction Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 56)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.4PTK2, TYMS, CDK6, ERBB2
2squamous cell carcinoma30.3CDK6, TYMS, PTK2, ERBB2
3gastric adenocarcinoma10.9
4barrett's adenocarcinoma10.4
5esophagus adenocarcinoma10.4
6esophagitis10.4
7barrett's esophagus10.3
8esophagus squamous cell carcinoma10.3
9gallbladder cancer10.0TYMS
10myeloma10.0IL1B
11peritonitis10.0IL1B
12adenoma10.0PTK2
13hepatocellular carcinoma10.0PTK2
14schizophrenia10.0PICK1
15fibrosarcoma10.0PTK2
16primary hyperoxaluria10.0IL1B
17papilloma10.0PTK2
18pancreatitis10.0IL1B
19neutropenia10.0TYMS, ERBB2
20oral cancer10.0DYT10
21biliary tract neoplasm10.0TYMS, ERBB2
22uremia10.0DYT10
23lung cancer10.0TYMS, ERBB2
24myeloid leukemia10.0DYT10
25gout10.0IL1B
26diarrhea10.0TYMS, ERBB2
27thyroid cancer10.0PTK2, CDK6
28factor vii deficiency10.0TYMS, ERBB2
29bladder carcinoma10.0TYMS, ERBB2
30stomach cancer10.0IL1B, TYMS, ERBB2
31chondrosarcoma10.0PTK2, EXT1
32malignant glioma10.0DYT10, PTK2
33adenoid cystic carcinoma10.0ERBB2, DYT10
34cervical cancer10.0ERBB2, PTK2, TYMS
35sarcoma10.0PTK2, CDK6, EXT1
36endometrial carcinoma10.0PTK2, ERBB2, CDK6
37osteosarcoma10.0DYT10, TYMS, EXT1
38colon adenocarcinoma10.0TYMS, DYT10, PTK2
39t-cell leukemia10.0TYMS, DYT10, CDK6
40colorectal cancer10.0TYMS, PTK2, ERBB2
41meningitis10.0IL1B, PTK2
42cholangiocarcinoma10.0PTK2, ERBB2, DYT10
43acute lymphocytic leukemia10.0TYMS, DYT10, CDK6
44squamous cell carcinoma of the head and neck10.0PTK2, TYMS, ERBB2, CDK6
45pancreatic cancer10.0TYMS, CDK6, PTK2, ERBB2
46ovarian cancer10.0TYMS, PTK2, ERBB2, CDK6
47lung adenocarcinoma10.0PTK2, DYT10, ERBB2
48non-small cell lung carcinoma10.0ERBB2, PTK2, CDK6, TYMS
49astrocytoma10.0DYT10, IL1B, PTK2
50melanoma10.0CDK6, PTK2, DYT10

Graphical network of the top 20 diseases related to Gastroesophageal Junction Adenocarcinoma:



Diseases related to gastroesophageal junction adenocarcinoma

Clinical Features for Gastroesophageal Junction Adenocarcinoma

About this section

Drugs & Therapeutics for Gastroesophageal Junction Adenocarcinoma

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Gastroesophageal Junction Adenocarcinoma

Drug clinical trials:

Search ClinicalTrials for Gastroesophageal Junction Adenocarcinoma

Search NIH Clinical Center for Gastroesophageal Junction Adenocarcinoma

Search CenterWatch for Gastroesophageal Junction Adenocarcinoma

Genetic Tests for Gastroesophageal Junction Adenocarcinoma

About this section

Anatomical Context for Gastroesophageal Junction Adenocarcinoma

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Gastroesophageal Junction Adenocarcinoma:

32
Lymph node, Liver, Pancreas, Testes

Animal Models for Gastroesophageal Junction Adenocarcinoma or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Gastroesophageal Junction Adenocarcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020067.8ERBB2, PTK2, IL1B, CDK6, EXT1

Publications for Gastroesophageal Junction Adenocarcinoma

About this section
Sources:
50PubMed
See all sources

Articles related to Gastroesophageal Junction Adenocarcinoma:

(show top 50)    (show all 61)
idTitleAuthorsYear
1
Prognostic importance and therapeutic implications of PAK1, a drugable protein kinase, in gastroesophageal junction adenocarcinoma. (24236193)
2013
2
Results of docetaxel plus oxaliplatin (DOCOX) A+ cetuximab in patients with metastatic gastric and/or gastroesophageal junction adenocarcinoma: results of a randomised Phase 2 study. (23747051)
2013
3
Snail1 correlates with patient outcomes in E-cadherin-preserved gastroesophageal junction adenocarcinoma. (24356933)
2013
4
Lymph node micrometastases of adenocarcinoma located in gastroesophagal junction. (24166601)
2013
5
The metastasis-associated gene MTA3, a component of the Mi-2/NuRD transcriptional repression complex, predicts prognosis of gastroesophageal junction adenocarcinoma. (23671646)
2013
6
HER2 expression and relevant clinicopathological features in gastric and gastroesophageal junction adenocarcinoma in a Chinese population. (23656792)
2013
7
Gastroesophageal junction adenocarcinoma metastasizing to gingiva. (23776844)
2013
8
Reconstructive options for gastroesophageal junction adenocarcinoma after Roux-en-Y gastric bypass. (23988286)
2013
9
A phase II study of neoadjuvant docetaxel, oxaliplatin, and S-1 (DOS) chemotherapy followed by surgery and adjuvant S-1 chemotherapy in potentially resectable gastric or gastroesophageal junction adenocarcinoma. (23921575)
2013
10
Unanswered questions in the management of gastroesophageal junction adenocarcinoma. (23714486)
2013
11
Genetic polymorphisms at TIMP3 are associated with survival of adenocarcinoma of the gastroesophageal junction. (23527119)
2013
12
The incidence and prognostic value of HER2 overexpression and cyclin D1 expression in patients with gastric or gastroesophageal junction adenocarcinoma in Israel. (23420289)
2013
13
HER2 expression in gastric and gastroesophageal junction adenocarcinoma in a US population: clinicopathologic analysis with proposed approach to HER2 assessment. (21617522)
2012
14
Postoperative intraperitoneal 5-fluoro-2'-deoxyuridine added to chemoradiation in patients curatively resected (R0) for locally advanced gastric and gastroesophageal junction adenocarcinoma. (21769462)
2012
15
Results of postoperative radiochemotherapy of the patients with resectable gastroesophageal junction adenocarcinoma in Slovenia. (23412351)
2012
16
HER2/neu gene amplification and protein overexpression in gastric and gastroesophageal junction adenocarcinoma: a review of histopathology, diagnostic testing, and clinical implications. (22646280)
2012
17
Relationship between gastroesophageal junction adenocarcinoma and Helicobacter pylori infection in Japan. (22472851)
2012
18
Clinicopathologic characteristics and survival outcomes of patients with advanced esophageal, gastroesophageal junction, and gastric adenocarcinoma: a single-institution experience. (23300355)
2012
19
A multicenter, phase II study of bortezomib (PS-341) in patients with unresectable or metastatic gastric and gastroesophageal junction adenocarcinoma. (20574790)
2011
20
Gastroesophageal junction adenocarcinoma of young patients who underwent curative surgery: a comparative analysis with older group. (21264755)
2011
21
Adjuvant bi-weekly combination of cisplatin, infusional 5-fluorouracil and folinic acid followed by concomitant chemoradiotherapy with infusional fluorouracil for high risk operated gastric and gastroesophageal junction adenocarcinoma. (21338186)
2010
22
Phase II study of sorafenib in combination with docetaxel and cisplatin in the treatment of metastatic or advanced gastric and gastroesophageal junction adenocarcinoma: ECOG 5203. (20458043)
2010
23
Array comparative genomic hybridization, expression array, and protein analysis of critical regions on chromosome arms 1q, 7q, and 8p in adenocarcinomas of the gastroesophageal junction. (19167610)
2009
24
Predictive value of initial PET-SUVmax in patients with locally advanced esophageal and gastroesophageal junction adenocarcinoma. (19487968)
2009
25
Local recurrence following adjuvant chemotherapy without radiotherapy in completely resected stomach and gastroesophageal junction adenocarcinoma. (19443416)
2009
26
Is radiation therapy needed in the treatment of gastroesophageal junction adenocarcinoma? (19343142)
2008
27
Molecular dissection of the chromosome band 7q21 amplicon in gastroesophageal junction adenocarcinomas identifies cyclin-dependent kinase 6 at both genomic and protein expression levels. (18438866)
2008
28
Irinotecan, docetaxel and oxaliplatin combination in metastatic gastric or gastroesophageal junction adenocarcinoma. (17667920)
2007
29
Anti-Yo-associated paraneoplastic cerebellar degeneration in a man with adenocarcinoma of the gastroesophageal junction. (17785986)
2007
30
High-resolution array comparative genomic hybridization of chromosome 8q: evaluation of putative progression markers for gastroesophageal junction adenocarcinomas. (18000363)
2007
31
Lymph node involvement in advanced gastroesophageal junction adenocarcinoma. (17662776)
2007
32
Interleukin-1 genetic polymorphisms and their relationship to the cancer anorexia/weight loss syndrome in metastatic gastric and gastroesophageal junction adenocarcinoma. (17265786)
2007
33
Phase II study of cetuximab in combination with FOLFIRI in patients with untreated advanced gastric or gastroesophageal junction adenocarcinoma (FOLCETUX study). (17164226)
2007
34
Molecular prognostic factors in adenocarcinoma of the esophagus and gastroesophageal junction. (17122988)
2007
35
Phase II trial of erlotinib in gastroesophageal junction and gastric adenocarcinomas: SWOG 0127. (17050876)
2006
36
Familiality in Barrett's esophagus, adenocarcinoma of the esophagus, and adenocarcinoma of the gastroesophageal junction. (16985029)
2006
37
Multicenter phase II study of irinotecan, cisplatin, and bevacizumab in patients with metastatic gastric or gastroesophageal junction adenocarcinoma. (17114652)
2006
38
A multi-center phase II study of sequential paclitaxel and bryostatin-1 (NSC 339555) in patients with untreated, advanced gastric or gastroesophageal junction adenocarcinoma. (16683077)
2006
39
Preservation of gastric acid secretion may be important for the development of gastroesophageal junction adenocarcinoma in Japanese people, irrespective of the H. pylori infection status. (16573782)
2006
40
Gastroesophageal junction adenocarcinoma: what are the factors influencing long-term survival? (16845860)
2006
41
Reduced p120ctn expression correlates with poor survival in patients with adenocarcinoma of the gastroesophageal junction. (16231374)
2005
42
Significance and prognostic value of lysosomal enzyme activities measured in surgically operated adenocarcinomas of the gastroesophageal junction and squamous cell carcinomas of the lower third of esophagus. (16270380)
2005
43
Comparison of the clinical and histological characteristics and survival of distal esophageal-gastroesophageal junction adenocarcinoma in patients with and without barrett mucosa. (15967904)
2005
44
Neuroendocrine in Barrett's mucosa and adenocarcinomas of the gastroesophageal junction. (15173916)
2004
45
Metastatic gastroesophageal junction adenocarcinoma to the extraocular muscles. (12578774)
2003
46
Molecular genetic analysis of the von Hippel-Lindau and human peroxisome proliferator-activated receptor gamma tumor-suppressor genes in adenocarcinomas of the gastroesophageal junction. (11745495)
2001
47
Gastroesophageal junction adenocarcinoma. (12057146)
2000
48
Comparative genomic hybridization of cancer of the gastroesophageal junction: deletion of 14Q31-32.1 discriminates between esophageal (Barrett's) and gastric cardia adenocarcinomas. (9973227)
1999
49
Paclitaxel and concurrent radiation therapy for locally advanced adenocarcinomas of the pancreas, stomach, and gastroesophageal junction. (10210540)
1999
50
A phase II study of 5-fluorouracil, leucovorin, adriamycin, and cisplatin (FLAP) for metastatic gastric and gastroesophageal junction adenocarcinoma. A Penn Cancer Clinical Trial Group and Roswell Park Cancer Institute Community Oncology Research Program Trial. (9167745)
1997

Genetic Variations for Gastroesophageal Junction Adenocarcinoma

About this section

Expression for genes affiliated with Gastroesophageal Junction Adenocarcinoma

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Gastroesophageal Junction Adenocarcinoma

Search GEO for disease gene expression data for Gastroesophageal Junction Adenocarcinoma.

Pathways for genes affiliated with Gastroesophageal Junction Adenocarcinoma

About this section
Sources:
59Tocris Bioscience, 53Reactome, 51QIAGEN, 37NCBI BioSystems Database, 29KEGG
See all sources

Pathways related to Gastroesophageal Junction Adenocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.7PTK2
2
Hide members
9.3ERBB2, PTK2
3
Hide members
9.3ERBB2, PTK2
4
Hide members
9.0PTK2, CDK6
5
Hide members
8.7CDK6, PTK2, ERBB2

Compounds for genes affiliated with Gastroesophageal Junction Adenocarcinoma

About this section
Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB, 2BitterDB
See all sources

Compounds related to Gastroesophageal Junction Adenocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1glutamate4410.6PICK1
2capecitabine44 49 1112.1TYMS, ERBB2
3vegf4410.1IL1B, TYMS
4levamisole44 1111.1TYMS, ERBB2
55-methylthioadenosine4410.1ERBB2, TYMS
6vinorelbine44 1111.0TYMS, ERBB2
7risedronate44 59 49 28 1114.0TYMS, IL1B
8taxane4410.0ERBB2, TYMS
9n-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide44 1111.0DYT10, ERBB2
10ag-126449.9IL1B, DYT10
11pd153035449.9DYT10, ERBB2
12n,n-dimethylsphingosine44 5910.9IL1B, DYT10
13mezerein449.9IL1B, DYT10
14dexamethasone44 49 28 1112.9PTK2
15aacocf3449.9IL1B, DYT10
16staurosporin449.8DYT10, IL1B
17cetuximab44 49 1111.8TYMS, ERBB2
18resveratrol44 59 11 2412.7ERBB2, PTK2
19polymyxin b449.6DYT10, IL1B
20methotrexate44 49 1111.6TYMS, IL1B, ERBB2
21gefitinib44 49 1111.5ERBB2, CDK6, TYMS
22phorbol 12,13-dibutyrate449.5DYT10, CDK6
2317-(allylamino)-17-demethoxygeldanamycin449.5ERBB2, CDK6
24valine449.5CDK6, TYMS, ERBB2
25docetaxel44 49 59 1112.3TYMS, ERBB2, PTK2
26calpeptin44 5910.3DYT10, PTK2
27quercetin44 59 11 2412.2TYMS, IL1B, PTK2
285fluorouracil449.2TYMS, PTK2, ERBB2
29ag 1478449.2PTK2, ERBB2, DYT10
30curcumin449.2IL1B, PTK2, ERBB2
31carbachol44 28 1111.1DYT10, PTK2, ERBB2
32ro 31 8220449.1PTK2, DYT10, IL1B
33c2ceramide449.1PTK2, DYT10, IL1B
34etoposide44 49 59 1112.0ERBB2, PTK2, TYMS
35gnrh449.0PTK2, DYT10, ERBB2
36tgf beta1448.9IL1B, PTK2, CDK6
37rottlerin448.9CDK6, PTK2, DYT10
38bapta448.8DYT10, PTK2
39erbstatin448.8ERBB2, PTK2, DYT10, IL1B
40n acetylcysteine448.7ERBB2, IL1B, PTK2, DYT10
41genistein44 28 59 2 11 2413.7PTK2, ERBB2, DYT10, IL1B
42cisplatin44 49 59 1111.7TYMS, CDK6, ERBB2, PTK2
43arginine448.6TYMS, EXT1, PTK2, ERBB2
44sb 20358044 599.6DYT10, IL1B, PTK2
45rapamycin448.6CDK6, ERBB2, PTK2, DYT10
46cycloheximide448.4PTK2, DYT10, IL1B, TYMS, ERBB2
47tamoxifen44 49 28 1111.2DYT10, TYMS, CDK6, PTK2, ERBB2
48herbimycin a44 599.1CDK6, PTK2, ERBB2, IL1B, DYT10
49ly294002448.1PTK2, ERBB2, DYT10, CDK6, IL1B
50serine447.9CDK6, ERBB2, DYT10, PTK2, PICK1, TYMS

GO Terms for genes affiliated with Gastroesophageal Junction Adenocarcinoma

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Gastroesophageal Junction Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell adhesionGO:0457859.0ERBB2, PTK2
2axon guidanceGO:0074118.9ERBB2, PTK2, EXT1
3positive regulation of protein phosphorylationGO:0019348.7ERBB2, PTK2, IL1B

Products for genes affiliated with Gastroesophageal Junction Adenocarcinoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gastroesophageal Junction Adenocarcinoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet