MCID: GST092
MIFTS: 60

Gastroesophageal Reflux malady

Gastrointestinal diseases category

Summaries for Gastroesophageal Reflux

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MedlinePlus:34 Your esophagus is the tube that carries food from your mouth to your stomach. gastroesophageal reflux disease (gerd) happens when a muscle at the end of your esophagus does not close properly. this allows stomach contents to leak back, or reflux, into the esophagus and irritate it. you may feel a burning in the chest or throat called heartburn. sometimes, you can taste stomach fluid in the back of the mouth. if you have these symptoms more than twice a week, you may have gerd. you can also have gerd without having heartburn. your symptoms could include a dry cough, asthma symptoms, or trouble swallowing. anyone, including infants and children, can have gerd. if not treated, it can lead to more serious health problems. in some cases, you might need medicines or surgery. however, many people can improve their symptoms by avoiding alcohol and spicy, fatty or acidic foods that trigger heartburn eating smaller meals not eating close to bedtime losing weight if needed wearing loose-fitting clothes nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Gastroesophageal Reflux, also known as gastroesophageal reflux disease, is related to esophagitis and obesity, and has symptoms including autosomal dominant inheritance, abnormality of metabolism/homeostasis and gastroesophageal reflux. An important gene associated with Gastroesophageal Reflux is GER (Gastroesophageal reflux), and among its related pathways are Gastrin-CREB signalling pathway via PKC and MAPK and Signaling by GPCR. The compounds bismuth subcitrate and enterogastrone have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and lung, and related mouse phenotypes are behavior/neurological and nervous system.

OMIM:47 Gastroesophageal reflux (GER) is characterized by the retrograde movement of stomach contents into the esophagus. In... (109350) more...

Wikipedia:65 Gastroesophageal reflux disease (GERD), gastro-oesophageal reflux disease (GORD), gastric reflux... more...

Aliases & Classifications for Gastroesophageal Reflux

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Gastroesophageal Reflux, Aliases & Descriptions:

Name: Gastroesophageal Reflux 47 10 11
Gastroesophageal Reflux Disease 10 12 45
Gerd 10 34
Gerd - Gastro-Esophageal Reflux Disease 10
 
Gastro-Esophageal Reflux 10
Gastresophageal Reflux 10
Acid Reflux 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

OMIM47 109350
Disease Ontology10 DOID:8534
MeSH35 D005764
ICD9CM29 530.81
NCIt40 C26781

Related Diseases for Gastroesophageal Reflux

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Diseases related to Gastroesophageal Reflux via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 303)
idRelated DiseaseScoreTop Affiliating Genes
1esophagitis31.7HRH2, NTS, CYP2C19
2obesity31.1CCK, NTS, CCKAR, PYY
3dyspepsia31.1CCK, HRH2
4asthma30.9SCT, NTS, HRH2
5irritable bowel syndrome30.9CCK
6adenocarcinoma30.9CCK, CCKAR, NTS, PYY, SCT
7morbid obesity30.9PYY, CCK
8duodenal ulcer30.6HRH2, SCT
9duodenogastric reflux30.6NTS, CCK
10gastritis30.6HRH2, CYP2C19, SCT, CCK, NTS
11gastric ulcer30.4CYP2C19, HRH2
12celiac disease30.4PYY, CCK
13peptic ulcer disease30.3HRH2, CCK, SCT, CYP2C19
14bulimia nervosa30.2PYY, CCK
15zollinger-ellison syndrome30.2SCT, HRH2
16constipation30.2CCK, PYY
17dumping syndrome30.2PYY, NTS
18laryngitis10.8
19hiatus hernia10.7
20esophageal atresia10.6
21pulmonary fibrosis10.5
22obstructive sleep apnea10.5
23chronic laryngitis10.5
24achalasia10.5
25atrial fibrillation10.5
26sleep apnea10.5
27bruxism10.4
28bronchiectasis10.4
29duodenitis10.4
30neuropathy10.4
31tooth erosion10.4
32neuropathy, hereditary sensory, type ib10.4
33bile reflux10.4
34chronic hiccups10.4
35laryngomalacia10.4
36dysphagia10.4
37blindness10.4
38pulmonary function10.3
39h. pylori infection10.3
40bronchiolitis obliterans10.3
41atrophic gastritis10.3
42bronchiolitis10.3
43cornelia de lange syndrome10.3
44peptic esophagitis10.3
45congenital diaphragmatic hernia10.3
46aspiration pneumonia10.3
47obstructive lung disease10.3
48pneumonia10.3
49rhinitis10.3
50ehlers-danlos syndrome classical type10.3

Graphical network of the top 20 diseases related to Gastroesophageal Reflux:



Diseases related to gastroesophageal reflux

Symptoms for Gastroesophageal Reflux

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Symptoms by clinical synopsis from OMIM:

109350

Clinical features from OMIM:

109350

HPO human phenotypes related to Gastroesophageal Reflux:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 abnormality of metabolism/homeostasis HP:0001939
3 gastroesophageal reflux HP:0002020
4 neoplasm HP:0002664
5 esophagitis HP:0100633

Drugs & Therapeutics for Gastroesophageal Reflux

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Drug clinical trials:

Search ClinicalTrials for Gastroesophageal Reflux

Search NIH Clinical Center for Gastroesophageal Reflux

Genetic Tests for Gastroesophageal Reflux

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Anatomical Context for Gastroesophageal Reflux

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MalaCards organs/tissues related to Gastroesophageal Reflux:

33
Kidney, Testes, Lung, Liver, T cells, Bone marrow, Bone, Cortex, Heart, Colon, Tongue

Animal Models for Gastroesophageal Reflux or affiliated genes

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MGI Mouse Phenotypes related to Gastroesophageal Reflux:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053867.8HRH2, NTS, CCKAR, SCT, PYY
2MP:00036317.2HRH2, NTS, CCKAR, CCK, SCT, PYY
3MP:00053767.0PYY, SCT, CCK, CCKAR, NTS, HRH2

Publications for Gastroesophageal Reflux

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Articles related to Gastroesophageal Reflux:

(show top 50)    (show all 789)
idTitleAuthorsYear
1
Factors affecting response to proton pump inhibitor therapy in patients with gastroesophageal reflux disease: a multicenter prospective observational study. (25851931)
2015
2
Impedance-detected Symptom Association and Number of Reflux Episodes as Pre-treatment Parameters That Predict Outcomes of Gastroesophageal Reflux Disease Patients. (25843082)
2015
3
Scintigraphy in laryngopharyngeal and gastroesophageal reflux disease: A definitive diagnostic test? (25834329)
2015
4
Is gastroesophageal reflux contribute to the development chronic cough by triggering pulmonary fibrosis. (25910367)
2014
5
Acidic and neutral liquid ingestion in patients with gastroesophageal reflux disease. (25296082)
2014
6
The effects of baclofen for the treatment of gastroesophageal reflux disease: a meta-analysis of randomized controlled trials. (25389436)
2014
7
Association of sleep dysfunction and emotional status with gastroesophageal reflux disease in Korea. (23875102)
2013
8
Gastroesophageal reflux disease. (23853605)
2013
9
The value of early wireless esophageal pH monitoring in diagnosing functional heartburn in refractory gastroesophageal reflux disease. (23765257)
2013
10
Helicobacter pylori infection has no impact on manometric and pH-metric findings in adolescents and young adults with gastroesophageal reflux and antral gastritis: eradication results to no significant clinical improvement. (23667732)
2013
11
Halitosis and tongue coating in patients with erosive gastroesophageal reflux disease versus nonerosive gastroesophageal reflux disease. (22437377)
2013
12
Systematic review of patient-reported outcome instruments for gastroesophageal reflux disease symptoms. (23202695)
2013
13
Rabeprazole 10 mg versus 20 mg in preventing relapse of gastroesophageal reflux disease: a meta-analysis. (23981627)
2013
14
Laparoscopic anterior 180-degree versus nissen fundoplication for gastroesophageal reflux disease: systematic review and meta-analysis of randomized clinical trials. (23470572)
2013
15
Association between atrophic gastritis and gastroesophageal reflux symptoms. (24634926)
2013
16
Relationships between sleep disturbances and gastroesophageal reflux disease in Asian sleep clinic referrals. (24290045)
2013
17
Sleep disturbances and refractory gastroesophageal reflux disease symptoms in patients receiving once-daily proton pump inhibitors and efficacy of twice-daily rabeprazole treatment. (24008338)
2013
18
High-resolution Manometry and Globus: Comparison of Globus, Gastroesophageal Reflux Disease and Normal Controls Using High-resolution Manometry. (24199007)
2013
19
Symptoms of gastroesophageal reflux disease improve after parathyroidectomy. (23158189)
2012
20
Hiatal hernia, Barrett's esophagus, and long-term symptom control after laparoscopic fundoplication for gastroesophageal reflux. (22648102)
2012
21
Gastroesophageal reflux disease--from reflux episodes to mucosal inflammation. (22105108)
2012
22
Oral symptoms including dental erosion in gastroesophageal reflux disease are associated with decreased salivary flow volume and swallowing function. (22200941)
2012
23
Assessment of desmosomal components (desmoglein 1-3, plakoglobin) in cardia mucosa in relation to gastroesophageal reflux disease and Helicobacter pylori infection. (22521077)
2012
24
The effect of Helicobacter pylori on gastroesophageal reflux disease. (23477175)
2012
25
A prospective multicenter registry of patients with chronic gastroesophageal reflux disease receiving transoral incisionless fundoplication. (22939637)
2012
26
Bravo 48-hour Wireless pH Monitoring in Patients With Non-cardiac Chest Pain. Objective Gastroesophageal Reflux Disease Parameters Predict the Responses to Proton Pump Inhibitors. (22523725)
2012
27
Frequency and clinical implications of supraesophageal and dyspeptic symptoms in gastroesophageal reflux disease. (22330237)
2012
28
Extraesophageal manifestations of gastroesophageal reflux disease: cough, asthma, laryngitis, chest pain. (22442097)
2012
29
Gastroesophageal reflux disease: another risk factor for atrial fibrillation? (22261930)
2011
30
Cow's Milk Allergy among Children with Gastroesophageal Reflux Disease. (21927657)
2011
31
Comparison of presentation and impact on quality of life of gastroesophageal reflux disease between young and old adults in a Chinese population. (22147968)
2011
32
Treatment of gastroesophageal reflux disease: a call for increase awareness and local research. (21465947)
2011
33
The value of Carlsson-dent questionnaire in diagnosis of gastroesophageal reflux disease in area with low prevalence of gastroesophageal reflux disease. (21602993)
2011
34
Symptom indexes in refractory gastroesophageal reflux disease: overrated or misunderstood? (21791195)
2011
35
Control of intragastric pH and its relationship to gastroesophageal reflux disease outcomes. (21694609)
2011
36
Do eosinophil numbers differentiate eosinophilic esophagitis from gastroesophageal reflux disease? (20524860)
2010
37
Menkes disease with gastroesophageal reflux disease and successful surgical treatment: a case report and literature review. (20718197)
2010
38
Gastroesophageal reflux, eosinophilic esophagitis, and foreign body. (21111120)
2010
39
Prevalence of bile reflux in gastroesophageal reflux disease patients not responsive to proton pump inhibitors. (19140233)
2009
40
Pylorospasm (simulating hypertrophic pyloric stenosis) with secondary gastroesophageal reflux. (18528245)
2008
41
Gastric ulcer after laparoscopic fundoplication for gastroesophageal reflux disease: significance of the eradication of Helicobacter pylori. (17581465)
2007
42
Gastroesophageal Reflux Disease (GERD) (21919262)
2005
43
Influence of cure of Helicobacter pylori infection on gastric acidity and gastroesophageal reflux: study by 24-h pH monitoring in patients with gastric or duodenal ulcer. (15870971)
2005
44
Gastroesophageal reflux disease, tooth erosion, and prosthodontic rehabilitation: a clinical report. (15061234)
2003
45
Effect of cytochrome P4502C19 genotypic differences on cure rates for gastroesophageal reflux disease by lansoprazole. (12386647)
2002
46
The role of gastroesophageal reflux in the pathogenesis of laryngeal carcinoma. (12430127)
2002
47
Head and neck manifestations of gastroesophageal reflux disease. (10498113)
1999
48
Enteral feeding associated gastroesophageal reflux and aspiration pneumonia: a review. (9063023)
1996
49
Complications of gastroesophageal reflux disease. Role of the lower esophageal sphincter, esophageal acid and acid/alkaline exposure, and duodenogastric reflux. (1632700)
1992
50
Apparent G syndrome presenting as neck and upper limb dystonia and severe gastroesophageal reflux. (3425612)
1987

Variations for Gastroesophageal Reflux

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Expression for genes affiliated with Gastroesophageal Reflux

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Search GEO for disease gene expression data for Gastroesophageal Reflux.

Pathways for genes affiliated with Gastroesophageal Reflux

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Compounds for genes affiliated with Gastroesophageal Reflux

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Compounds related to Gastroesophageal Reflux according to GeneCards/GeneDecks:

(show top 50)    (show all 127)
idCompoundScoreTop Affiliating Genes
1bismuth subcitrate459.9DSPP, HRH2
2enterogastrone459.8PYY, CCK
31,4-benzodiazepine459.7CCKAR, CCK
4asperlicin459.7CCK, CCKAR
5epft459.7CCK, SCT
6cisapride45 30 1311.6CCK, HRH2, CYP2C19
7amoxicillin45 51 1311.6DSPP, CYP2C19, HRH2
8benzodiazepines459.6CCKAR, CCK, HRH2
9intralipid459.5CCKAR, CCK, PYY
10pepsinogen459.5SCT, HRH2, CCK
11caerulein459.3SCT, CCKAR, CCK
12acetaminophen45 3 51 26 1313.3HRH2, CYP2C19, PYY, CCK
13diphenhydramine45 30 3 26 1313.3CYP2C19, HRH2, NTS
14cimetidine45 30 1311.2HRH2, CYP2C19, SCT
15ym022459.2CCKAR, CCK
16ranitidine45 30 26 1312.1SCT, CCK, HRH2, CYP2C19
17benzodiazepine459.0CCKAR, NTS, CCK
18carbohydrates458.9CCK, CCKAR, DSPP, PYY
19amphetamine45 51 1310.9CCK, PYY, NTS
205-hydroxytryptamine458.8HRH2, NTS, CCK, PYY
21haloperidol45 51 30 3 1312.7NTS, CCKAR, PYY, CYP2C19
22amine458.7NTS, SCT, PYY, HRH2
23cocaine45 139.7CCKAR, NTS, CCK, PYY
24carbon458.7DSPP, CCK, HRH2, NTS
25bicarbonate458.6SCT, HRH2, NTS, CCK
26oxyntomodulin45 619.6PYY, CCK, NTS, SCT
27isoproterenol45 139.6NTS, SCT, PYY, HRH2
28c-peptide458.6PYY, SCT, CCK, NTS
29clonidine45 51 30 1311.6NTS, SCT, PYY
30carbachol45 30 1310.6PYY, SCT, CCK, NTS
31oleic acid45 30 26 1311.5SCT, PYY, CCKAR, NTS
32loxiglumide458.5SCT, CCKAR, NTS, CCK
33acth458.5SCT, NTS, CCK, PYY
34guanine45 26 1310.4CCKAR, SCT, HRH2, NTS
35epinephrine45 26 1310.4DSPP, SCT, NTS, HRH2
36indomethacin45 30 61 1311.3NTS, SCT, CCKAR, CYP2C19
37ethanol45 51 26 1311.3PYY, SCT, NTS, HRH2, CYP2C19
38histamine45 30 2610.3HRH2, NTS, CCK, SCT, PYY
39acetylcholine45 51 30 26 1312.3SCT, CCK, HRH2, NTS, PYY
40norepinephrine45 26 1310.2NTS, CCK, SCT, PYY
41omeprazole45 51 30 26 1312.2PYY, HRH2, CCKAR, CCK, SCT, CYP2C19
42octreotide45 61 30 1311.1NTS, CCK, SCT, PYY, CCKAR
43cyclic amp45 269.1CCKAR, NTS, SCT, PYY, HRH2
44gaba458.1SCT, CCK, NTS, CCKAR, PYY
45atropine45 30 139.8PYY, SCT, CCK, NTS, HRH2, CCKAR
46tetrodotoxin45 61 309.8CCK, SCT, PYY, CCKAR, NTS, HRH2
47dopamine45 30 26 1310.7SCT, NTS, CCKAR, CCK, CYP2C19, PYY
48lipid457.7CCKAR, CYP2C19, SCT, PYY, NTS, HRH2
49arginine457.7NTS, CCK, DSPP, SCT, PYY
50calcium45 51 26 1310.1SCT, HRH2, CCK, DSPP, CCKAR, NTS

GO Terms for genes affiliated with Gastroesophageal Reflux

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Cellular components related to Gastroesophageal Reflux according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.7NTS, CCK, DSPP, SCT, PYY

Biological processes related to Gastroesophageal Reflux according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1eating behaviorGO:00427559.7CCK, PYY
2feeding behaviorGO:00076319.6CCKAR, PYY
3axonogenesisGO:00074099.5CCKAR, CCK
4visual learningGO:00085429.4SCT, HRH2
5digestionGO:00075869.3CCKAR, PYY

Molecular functions related to Gastroesophageal Reflux according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051799.0CCK, SCT, PYY
2neuropeptide hormone activityGO:00051848.5NTS, CCK, PYY

Products for genes affiliated with Gastroesophageal Reflux

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Sources for Gastroesophageal Reflux

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet