MCID: GST092
MIFTS: 60

Gastroesophageal Reflux malady

Gastrointestinal diseases category

Summaries for Gastroesophageal Reflux

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MedlinePlus:32 Your esophagus is the tube that carries food from your mouth to your stomach. gastroesophageal reflux disease (gerd) happens when a muscle at the end of your esophagus does not close properly. this allows stomach contents to leak back, or reflux, into the esophagus and irritate it. you may feel a burning in the chest or throat called heartburn. sometimes, you can taste stomach fluid in the back of the mouth. if you have these symptoms more than twice a week, you may have gerd. you can also have gerd without having heartburn. your symptoms could include a dry cough, asthma symptoms, or trouble swallowing. anyone, including infants and children, can have gerd. if not treated, it can lead to more serious health problems. in some cases, you might need medicines or surgery. however, many people can improve their symptoms by avoiding alcohol and spicy, fatty or acidic foods that trigger heartburn eating smaller meals not eating close to bedtime losing weight if needed wearing loose-fitting clothes nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Gastroesophageal Reflux, also known as gastroesophageal reflux disease, is related to esophagitis and dyspepsia, and has symptoms including autosomal dominant inheritance, abnormality of metabolism/homeostasis and gastroesophageal reflux. An important gene associated with Gastroesophageal Reflux is GER (Gastroesophageal reflux), and among its related pathways are Gastrin-CREB signalling pathway via PKC and MAPK and Signaling by GPCR. The drugs aluminum hydroxide and aluminum hydroxide gel and the compounds bismuth subcitrate and enterogastrone have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and lung, and related mouse phenotypes are behavior/neurological and nervous system.

OMIM:45 Gastroesophageal reflux (GER) is characterized by the retrograde movement of stomach contents into the esophagus. In... (109350) more...

Wikipedia:63 Gastroesophageal reflux disease (GERD), gastro-oesophageal reflux disease (GORD), gastric reflux... more...

Aliases & Classifications for Gastroesophageal Reflux

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Gastroesophageal Reflux, Aliases & Descriptions:

Name: Gastroesophageal Reflux 45 9 10
Gastroesophageal Reflux Disease 9 11 43 60
Gerd 9 32
Gerd - Gastro-Esophageal Reflux Disease 9
 
Gastro-Esophageal Reflux 9
Gastresophageal Reflux 9
Acid Reflux 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

OMIM45 109350
Disease Ontology9 DOID:8534
MeSH33 D005764
ICD9CM27 530.81
NCIt38 C26781

Related Diseases for Gastroesophageal Reflux

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Graphical network of the top 20 diseases related to Gastroesophageal Reflux:



Diseases related to gastroesophageal reflux

Symptoms for Gastroesophageal Reflux

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Symptoms by clinical synopsis from OMIM:

109350

Clinical features from OMIM:

109350

HPO human phenotypes related to Gastroesophageal Reflux:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 abnormality of metabolism/homeostasis HP:0001939
3 gastroesophageal reflux HP:0002020
4 neoplasm HP:0002664
5 esophagitis HP:0100633

Genetic Tests for Gastroesophageal Reflux

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Anatomical Context for Gastroesophageal Reflux

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MalaCards organs/tissues related to Gastroesophageal Reflux:

31
Kidney, Testes, Lung, Liver, T cells, Bone marrow, Bone, Cortex, Heart, Colon, Tongue

Animal Models for Gastroesophageal Reflux or affiliated genes

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MGI Mouse Phenotypes related to Gastroesophageal Reflux:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053867.8HRH2, NTS, CCKAR, SCT, PYY
2MP:00036317.2HRH2, NTS, CCKAR, CCK, SCT, PYY
3MP:00053767.0PYY, SCT, CCK, CCKAR, NTS, HRH2

Publications for Gastroesophageal Reflux

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Articles related to Gastroesophageal Reflux:

(show top 50)    (show all 789)
idTitleAuthorsYear
1
Factors affecting response to proton pump inhibitor therapy in patients with gastroesophageal reflux disease: a multicenter prospective observational study. (25851931)
2015
2
Impedance-detected Symptom Association and Number of Reflux Episodes as Pre-treatment Parameters That Predict Outcomes of Gastroesophageal Reflux Disease Patients. (25843082)
2015
3
Scintigraphy in laryngopharyngeal and gastroesophageal reflux disease: A definitive diagnostic test? (25834329)
2015
4
Is gastroesophageal reflux contribute to the development chronic cough by triggering pulmonary fibrosis. (25910367)
2014
5
Acidic and neutral liquid ingestion in patients with gastroesophageal reflux disease. (25296082)
2014
6
The effects of baclofen for the treatment of gastroesophageal reflux disease: a meta-analysis of randomized controlled trials. (25389436)
2014
7
Association of sleep dysfunction and emotional status with gastroesophageal reflux disease in Korea. (23875102)
2013
8
Gastroesophageal reflux disease. (23853605)
2013
9
The value of early wireless esophageal pH monitoring in diagnosing functional heartburn in refractory gastroesophageal reflux disease. (23765257)
2013
10
Helicobacter pylori infection has no impact on manometric and pH-metric findings in adolescents and young adults with gastroesophageal reflux and antral gastritis: eradication results to no significant clinical improvement. (23667732)
2013
11
Halitosis and tongue coating in patients with erosive gastroesophageal reflux disease versus nonerosive gastroesophageal reflux disease. (22437377)
2013
12
Systematic review of patient-reported outcome instruments for gastroesophageal reflux disease symptoms. (23202695)
2013
13
Rabeprazole 10 mg versus 20 mg in preventing relapse of gastroesophageal reflux disease: a meta-analysis. (23981627)
2013
14
Laparoscopic anterior 180-degree versus nissen fundoplication for gastroesophageal reflux disease: systematic review and meta-analysis of randomized clinical trials. (23470572)
2013
15
Association between atrophic gastritis and gastroesophageal reflux symptoms. (24634926)
2013
16
Relationships between sleep disturbances and gastroesophageal reflux disease in Asian sleep clinic referrals. (24290045)
2013
17
Sleep disturbances and refractory gastroesophageal reflux disease symptoms in patients receiving once-daily proton pump inhibitors and efficacy of twice-daily rabeprazole treatment. (24008338)
2013
18
High-resolution Manometry and Globus: Comparison of Globus, Gastroesophageal Reflux Disease and Normal Controls Using High-resolution Manometry. (24199007)
2013
19
Symptoms of gastroesophageal reflux disease improve after parathyroidectomy. (23158189)
2012
20
Hiatal hernia, Barrett's esophagus, and long-term symptom control after laparoscopic fundoplication for gastroesophageal reflux. (22648102)
2012
21
Gastroesophageal reflux disease--from reflux episodes to mucosal inflammation. (22105108)
2012
22
Oral symptoms including dental erosion in gastroesophageal reflux disease are associated with decreased salivary flow volume and swallowing function. (22200941)
2012
23
Assessment of desmosomal components (desmoglein 1-3, plakoglobin) in cardia mucosa in relation to gastroesophageal reflux disease and Helicobacter pylori infection. (22521077)
2012
24
The effect of Helicobacter pylori on gastroesophageal reflux disease. (23477175)
2012
25
A prospective multicenter registry of patients with chronic gastroesophageal reflux disease receiving transoral incisionless fundoplication. (22939637)
2012
26
Bravo 48-hour Wireless pH Monitoring in Patients With Non-cardiac Chest Pain. Objective Gastroesophageal Reflux Disease Parameters Predict the Responses to Proton Pump Inhibitors. (22523725)
2012
27
Frequency and clinical implications of supraesophageal and dyspeptic symptoms in gastroesophageal reflux disease. (22330237)
2012
28
Extraesophageal manifestations of gastroesophageal reflux disease: cough, asthma, laryngitis, chest pain. (22442097)
2012
29
Gastroesophageal reflux disease: another risk factor for atrial fibrillation? (22261930)
2011
30
Cow's Milk Allergy among Children with Gastroesophageal Reflux Disease. (21927657)
2011
31
Comparison of presentation and impact on quality of life of gastroesophageal reflux disease between young and old adults in a Chinese population. (22147968)
2011
32
Treatment of gastroesophageal reflux disease: a call for increase awareness and local research. (21465947)
2011
33
The value of Carlsson-dent questionnaire in diagnosis of gastroesophageal reflux disease in area with low prevalence of gastroesophageal reflux disease. (21602993)
2011
34
Symptom indexes in refractory gastroesophageal reflux disease: overrated or misunderstood? (21791195)
2011
35
Control of intragastric pH and its relationship to gastroesophageal reflux disease outcomes. (21694609)
2011
36
Do eosinophil numbers differentiate eosinophilic esophagitis from gastroesophageal reflux disease? (20524860)
2010
37
Menkes disease with gastroesophageal reflux disease and successful surgical treatment: a case report and literature review. (20718197)
2010
38
Gastroesophageal reflux, eosinophilic esophagitis, and foreign body. (21111120)
2010
39
Prevalence of bile reflux in gastroesophageal reflux disease patients not responsive to proton pump inhibitors. (19140233)
2009
40
Pylorospasm (simulating hypertrophic pyloric stenosis) with secondary gastroesophageal reflux. (18528245)
2008
41
Gastric ulcer after laparoscopic fundoplication for gastroesophageal reflux disease: significance of the eradication of Helicobacter pylori. (17581465)
2007
42
Gastroesophageal Reflux Disease (GERD) (21919262)
2005
43
Influence of cure of Helicobacter pylori infection on gastric acidity and gastroesophageal reflux: study by 24-h pH monitoring in patients with gastric or duodenal ulcer. (15870971)
2005
44
Gastroesophageal reflux disease, tooth erosion, and prosthodontic rehabilitation: a clinical report. (15061234)
2003
45
Effect of cytochrome P4502C19 genotypic differences on cure rates for gastroesophageal reflux disease by lansoprazole. (12386647)
2002
46
The role of gastroesophageal reflux in the pathogenesis of laryngeal carcinoma. (12430127)
2002
47
Head and neck manifestations of gastroesophageal reflux disease. (10498113)
1999
48
Enteral feeding associated gastroesophageal reflux and aspiration pneumonia: a review. (9063023)
1996
49
Complications of gastroesophageal reflux disease. Role of the lower esophageal sphincter, esophageal acid and acid/alkaline exposure, and duodenogastric reflux. (1632700)
1992
50
Apparent G syndrome presenting as neck and upper limb dystonia and severe gastroesophageal reflux. (3425612)
1987

Variations for Gastroesophageal Reflux

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Expression for genes affiliated with Gastroesophageal Reflux

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Search GEO for disease gene expression data for Gastroesophageal Reflux.

Pathways for genes affiliated with Gastroesophageal Reflux

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Compounds for genes affiliated with Gastroesophageal Reflux

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Compounds related to Gastroesophageal Reflux according to GeneCards Suite gene sharing:

(show top 50)    (show all 127)
idCompoundScoreTop Affiliating Genes
1bismuth subcitrate439.9DSPP, HRH2
2enterogastrone439.8PYY, CCK
31,4-benzodiazepine439.7CCK, CCKAR
4asperlicin439.7CCK, CCKAR
5epft439.7SCT, CCK
6cisapride43 28 1211.6CYP2C19, CCK, HRH2
7amoxicillin43 49 1211.6HRH2, DSPP, CYP2C19
8benzodiazepines439.6CCK, CCKAR, HRH2
9intralipid439.5CCKAR, CCK, PYY
10pepsinogen439.5HRH2, CCK, SCT
11caerulein439.3CCKAR, CCK, SCT
12acetaminophen43 2 49 24 1213.3HRH2, CCK, CYP2C19, PYY
13diphenhydramine43 28 2 24 1213.3CYP2C19, NTS, HRH2
14cimetidine43 28 1211.2CYP2C19, SCT, HRH2
15ym022439.2CCKAR, CCK
16ranitidine43 28 24 1212.1CYP2C19, SCT, CCK, HRH2
17benzodiazepine439.0CCK, CCKAR, NTS
18carbohydrates438.9PYY, DSPP, CCK, CCKAR
19amphetamine43 49 1210.9PYY, CCK, NTS
205-hydroxytryptamine438.8HRH2, NTS, CCK, PYY
21haloperidol43 49 28 2 1212.7PYY, CYP2C19, CCKAR, NTS
22amine438.7PYY, SCT, NTS, HRH2
23cocaine43 129.7PYY, CCK, CCKAR, NTS
24carbon438.7HRH2, NTS, CCK, DSPP
25bicarbonate438.6SCT, CCK, NTS, HRH2
26oxyntomodulin43 599.6NTS, CCK, SCT, PYY
27isoproterenol43 129.6PYY, SCT, NTS, HRH2
28c-peptide438.6PYY, SCT, CCK, NTS
29carbachol43 28 1210.6PYY, SCT, CCK, NTS
30clonidine43 49 28 1211.6NTS, SCT, PYY
31oleic acid43 28 24 1211.5PYY, SCT, CCKAR, NTS
32loxiglumide438.5NTS, CCKAR, CCK, SCT
33acth438.5PYY, SCT, CCK, NTS
34guanine43 24 1210.4HRH2, NTS, CCKAR, SCT
35epinephrine43 24 1210.4HRH2, NTS, DSPP, SCT
36indomethacin43 28 59 1211.3CYP2C19, SCT, CCKAR, NTS
37ethanol43 49 24 1211.3PYY, CYP2C19, SCT, NTS, HRH2
38histamine43 28 2410.3HRH2, NTS, CCK, SCT, PYY
39acetylcholine43 49 28 24 1212.3PYY, SCT, CCK, NTS, HRH2
40norepinephrine43 24 1210.2PYY, SCT, CCK, NTS
41omeprazole43 49 28 24 1212.2HRH2, CCKAR, CCK, SCT, CYP2C19, PYY
42octreotide43 59 28 1211.1PYY, SCT, CCK, CCKAR, NTS
43cyclic amp43 249.1PYY, SCT, CCKAR, NTS, HRH2
44gaba438.1PYY, SCT, CCK, CCKAR, NTS
45atropine43 28 129.8PYY, SCT, CCK, CCKAR, NTS, HRH2
46tetrodotoxin43 59 289.8PYY, SCT, CCK, CCKAR, NTS, HRH2
47dopamine43 28 24 1210.7PYY, CYP2C19, SCT, CCK, CCKAR, NTS
48lipid437.7PYY, CYP2C19, SCT, CCKAR, NTS, HRH2
49arginine437.7PYY, SCT, DSPP, CCK, NTS
50calcium43 49 24 1210.1PYY, SCT, DSPP, CCK, CCKAR, NTS

GO Terms for genes affiliated with Gastroesophageal Reflux

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Cellular components related to Gastroesophageal Reflux according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.7NTS, CCK, DSPP, SCT, PYY

Biological processes related to Gastroesophageal Reflux according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1eating behaviorGO:00427559.7PYY, CCK
2feeding behaviorGO:00076319.6PYY, CCKAR
3axonogenesisGO:00074099.5CCK, CCKAR
4visual learningGO:00085429.4HRH2, SCT
5digestionGO:00075869.3PYY, CCKAR

Molecular functions related to Gastroesophageal Reflux according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051799.0CCK, SCT, PYY
2neuropeptide hormone activityGO:00051848.5NTS, CCK, PYY

Products for genes affiliated with Gastroesophageal Reflux

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  • Antibodies
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  • Kits and Assays

Sources for Gastroesophageal Reflux

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet