GERD
MCID: GST092
MIFTS: 62

Gastroesophageal Reflux (GERD) malady

Categories: Gastrointestinal diseases

Aliases & Classifications for Gastroesophageal Reflux

Aliases & Descriptions for Gastroesophageal Reflux:

Name: Gastroesophageal Reflux 54 12 13 42 14
Gastroesophageal Reflux Disease 12 29 52 14 69
Gerd 12 41
Gerd - Gastro-Esophageal Reflux Disease 12
Gastro-Esophageal Reflux 12
Gastresophageal Reflux 12
Acid Reflux 12

Characteristics:

HPO:

32
gastroesophageal reflux:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 54 109350
Disease Ontology 12 DOID:8534
ICD10 33 K21 K21.9
ICD9CM 35 530.81
MeSH 42 D005764
UMLS 69 C0017168

Summaries for Gastroesophageal Reflux

MedlinePlus : 41 your esophagus is the tube that carries food from your mouth to your stomach. gastroesophageal reflux disease (gerd) happens when a muscle at the end of your esophagus does not close properly. this allows stomach contents to leak back, or reflux, into the esophagus and irritate it. you may feel a burning in the chest or throat called heartburn. sometimes, you can taste stomach fluid in the back of the mouth. if you have these symptoms more than twice a week, you may have gerd. you can also have gerd without having heartburn. your symptoms could include a dry cough, asthma symptoms, or trouble swallowing. anyone, including infants and children, can have gerd. if not treated, it can lead to more serious health problems. in some cases, you might need medicines or surgery. however, many people can improve their symptoms by avoiding alcohol and spicy, fatty or acidic foods that trigger heartburn eating smaller meals not eating close to bedtime losing weight if needed wearing loose-fitting clothes nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary : Gastroesophageal Reflux, also known as gastroesophageal reflux disease, is related to chagas disease and cervicitis, and has symptoms including esophagitis, barrett esophagus and abdominal pain. An important gene associated with Gastroesophageal Reflux is GER (Gastroesophageal Reflux), and among its related pathways/superpathways are Folate Metabolism and Toll Comparative Pathway. The drugs Dopamine and Baclofen have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and lung, and related phenotypes are behavior/neurological and endocrine/exocrine gland

OMIM : 54 Gastroesophageal reflux (GER) is characterized by the retrograde movement of stomach contents into the esophagus. In... (109350) more...

Wikipedia : 71 Gastroesophageal reflux disease (GERD), also known as acid reflux, is a long-term condition where... more...

Related Diseases for Gastroesophageal Reflux

Diseases related to Gastroesophageal Reflux via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 208)
id Related Disease Score Top Affiliating Genes
1 chagas disease 29.5 CCK GHRL PYY
2 cervicitis 29.3 CCK PTGS1 PTGS2
3 hiatus hernia 11.5
4 spastic paraplegia 9a, autosomal dominant 11.3
5 neuropathy, hereditary sensory, type ib 11.3
6 dyspepsia 11.3
7 chronic laryngitis 11.3
8 laryngomalacia 11.3
9 chronic hiccups 11.3
10 barrett esophagus/esophageal adenocarcinoma 11.2
11 spastic paraplegia 9 11.0
12 combined oxidative phosphorylation deficiency 19 11.0
13 sudden infant death with dysgenesis of the testes syndrome 11.0
14 down syndrome 11.0
15 neuropathy, hereditary sensory and autonomic, type ia 11.0
16 diffuse cutaneous systemic sclerosis 11.0
17 mental retardation, x-linked 98 11.0
18 swallowing disorders 11.0
19 encephalopathy, neonatal severe 11.0
20 mental retardation, x-linked syndromic, lubs type 11.0
21 esophagitis 10.7
22 obesity 10.4
23 laryngitis 10.4
24 adenocarcinoma 10.3
25 asthma 10.3
26 oculomotor nerve paralysis 10.2 CXCL8 IL1B
27 esophageal atresia 10.2
28 common peroneal nerve lesion 10.2 CXCL8 IL1B
29 gemistocytic astrocytoma 10.2 CCK GAST HRH2
30 irritable bowel syndrome 10.2
31 progressive relapsing multiple sclerosis 10.2 GAST HRH2 NTS
32 morbid obesity 10.2
33 mucositis 10.2
34 adult brain stem glioma 10.1 CCK GAST NTS
35 achalasia 10.1
36 lacrimal apparatus disease 10.1 CXCL8 CYP2C19 HRH2 IL1B
37 paranasal sinus cancer, adult 10.1 GAST NTS
38 rickets 10.1 CCK NTS PYY
39 atrial fibrillation 10.1
40 gastritis 10.1
41 pulmonary fibrosis 10.1
42 sleep apnea 10.1
43 obstructive sleep apnea 10.1
44 lung disease 10.1
45 milk allergy 10.1
46 endocrine gland cancer 10.1 CCK GAST NTS
47 ischemic neuropathy 10.0 CCK GAST GHRL
48 nutritional optic neuropathy 10.0 GAST GHRL
49 bile duct clear cell adenocarcinoma 10.0 PTGS2 TP53
50 bronchiectasis 10.0

Comorbidity relations with Gastroesophageal Reflux via Phenotypic Disease Network (PDN): (show all 14)


Acute Cystitis Anxiety Disorder
Bronchitis Chronic Myocardial Ischemia
Deficiency Anemia Dyskinesia of Esophagus
Esophagitis Heart Disease
Hypertension, Essential Hypothyroidism
Intermediate Coronary Syndrome Ischemic Heart Disease
Osteoporosis Peptic Esophagitis

Graphical network of the top 20 diseases related to Gastroesophageal Reflux:



Diseases related to Gastroesophageal Reflux

Symptoms & Phenotypes for Gastroesophageal Reflux

Symptoms by clinical synopsis from OMIM:

109350

Clinical features from OMIM:

109350

Human phenotypes related to Gastroesophageal Reflux:

32
id Description HPO Frequency HPO Source Accession
1 gastroesophageal reflux 32 HP:0002020
2 esophagitis 32 HP:0100633
3 barrett esophagus 32 HP:0100580

UMLS symptoms related to Gastroesophageal Reflux:


abdominal pain, constipation, diarrhea, dyspepsia, heartburn, icterus, nausea and vomiting, gastrointestinal gas

MGI Mouse Phenotypes related to Gastroesophageal Reflux:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.97 CCK F2RL1 GHRL HRH2 NTS PTGS1
2 endocrine/exocrine gland MP:0005379 9.81 CCK CDX2 F2RL1 GAST GHRL HRH2
3 digestive/alimentary MP:0005381 9.8 CDX2 GAST GHRL HRH2 PTGS1 PTGS2
4 homeostasis/metabolism MP:0005376 9.73 CCK CDX2 F2RL1 GAST GHRL HRH2
5 neoplasm MP:0002006 9.17 TP53 CDX2 F2RL1 GAST IL1B PTGS1

Drugs & Therapeutics for Gastroesophageal Reflux

Drugs for Gastroesophageal Reflux (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 423)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 3 51-61-6, 62-31-7 681
2
Baclofen Approved Phase 4,Phase 3,Phase 2,Phase 1 1134-47-0 2284
3
Pantoprazole Approved Phase 4,Phase 3,Phase 2,Phase 1 102625-70-7 4679
4
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 73590-58-6 4594
5
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
6
Sulfamethoxazole Approved Phase 4,Phase 3,Phase 1,Phase 2 723-46-6 5329
7
Lansoprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 103577-45-3 3883
8
Rabeprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 117976-89-3 5029
9
Esomeprazole Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 161796-78-7, 119141-88-7 4594 9579578
10
Trimethoprim Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 738-70-5 5578
11
Domperidone Approved, Investigational, Vet_approved Phase 4,Phase 3 57808-66-9 3151
12
Benzocaine Approved Phase 4,Phase 3 1994-09-7, 94-09-7 2337
13
Menthol Approved Phase 4,Phase 3 2216-51-5 16666
14
Ethanol Approved Phase 4,Phase 3,Phase 2 64-17-5 702
15
Cimetidine Approved Phase 4 51481-61-9 2756
16
Nitrofurantoin Approved, Vet_approved Phase 4,Phase 3 67-20-9 5353830
17
Metoclopramide Approved, Investigational Phase 4,Phase 3 364-62-5 4168
18
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 75614-87-8, 51-45-6 774
19
Ranitidine Approved Phase 4,Phase 3,Phase 2,Phase 1 66357-59-3, 66357-35-5 3001055
20
Propranolol Approved, Investigational Phase 4 525-66-6 4946
21
Famotidine Approved Phase 4,Phase 2,Phase 3 76824-35-6 3325
22
Risperidone Approved, Investigational Phase 4,Phase 2,Phase 3 106266-06-2 5073
23
Dronabinol Approved, Illicit Phase 4 1972-08-3 16078 2978
24
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
25
Clarithromycin Approved Phase 4 81103-11-9 84029
26
Amoxicillin Approved, Vet_approved Phase 4,Phase 3 26787-78-0 33613 2171
27
Nortriptyline Approved Phase 4,Phase 3,Phase 2 72-69-5 4543
28
Nizatidine Approved Phase 4,Phase 3 76963-41-2 3033637
29
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
30
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
31
Sodium Tetradecyl Sulfate Approved Phase 4 1191-50-0, 139-88-8 14492 5248
32
Aluminum hydroxide Approved Phase 4,Phase 3,Phase 1 21645-51-2
33
Polidocanol Approved Phase 4,Phase 3,Phase 1 9002-92-0
34
Magnesium Hydroxide Approved Phase 4,Phase 1 1309-42-8
35 Magnesium trisilicate Approved Phase 4,Phase 3,Phase 1 14987-04-3
36
Verapamil Approved Phase 4 52-53-9 2520
37
Citalopram Approved Phase 4 59729-33-8 2771
38 Trimebutine Approved Phase 4 39133-31-8
39
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
40
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
41
Clozapine Approved Phase 4 5786-21-0 2818
42
Ziprasidone Approved Phase 4 146939-27-7 60854
43
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
44
Asenapine Approved Phase 4 85650-56-2, 65576-45-6 3001386
45
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 1,Phase 2 58-05-9 54575, 6560146 143
46 tannic acid Approved, Nutraceutical Phase 4,Phase 3
47
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 59-30-3 6037
48
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
49
Maleic acid Experimental Phase 4 110-16-7 444266
50 mometasone furoate Phase 4,Phase 2 83919-23-7

Interventional clinical trials:

(show top 50) (show all 1025)
id Name Status NCT ID Phase
1 A Randomized, Double-Blind, Placebo-Controlled Study of Gastroesophageal Reflux Disease Therapy. Unknown status NCT00237068 Phase 4
2 Randomized, Double Blind, Placebo Control Trial to Evaluate the Efficacy of Wu-Chu-Yu Tang on Gastroesophageal Reflux Disease (GERD) Unknown status NCT01822106 Phase 4
3 Dexlansoprazole to Treat Laryngopharyngeal Reflux and Lingual Tonsil Hypertrophy Unknown status NCT01328652 Phase 4
4 Esomeprazole Plus Alginate vs. Esomeprazole Alone for Treatment of Nighttime Reflux Symptom and Sleep Disturbances Unknown status NCT02277886 Phase 4
5 The Relationship Between Gastroesophageal Reflux and Pediatric Rhinitis: Significance of Pale/Blue Colored Turbinate Unknown status NCT02278081 Phase 4
6 Research of Efficient Use of Omeprazole in Combination With Domperidone in Gastroesophageal Reflux Disease of Mild to Moderate Severity Unknown status NCT02140073 Phase 4
7 LGG for Prevention of Infectious Complications During PPI Treatment in Children Unknown status NCT01782118 Phase 4
8 A Prospective Study Comparing the Success Rate of Injection of (DefluxR) Versus (VantrisR) for VUR in Children Unknown status NCT02271035 Phase 4
9 Clasic Laryngeal Mask Airway(C-LMA) and I-gel Releated Regurgitation and Complications Unknown status NCT01876836 Phase 4
10 ClosureFAST - Radiofrequency Great Saphenous Vein Treatment Unknown status NCT00842296 Phase 4
11 PPI-Rebound-Trial. A Study of the Clinical Relevance of the Acid Rebound Phenomena Unknown status NCT00526006 Phase 4
12 Gastric Functions & Proton Pump Inhibitor( PPI) Study Unknown status NCT00951431 Phase 4
13 Clinical Study of Laparoscopic Non Banded Vertical Gastroplasty in Bariatric Surgery Unknown status NCT02050477 Phase 4
14 Placebo Controlled Study of Baclofen for GERD in Children With Cerebral Palsy Unknown status NCT01386255 Phase 4
15 Evaluation of the Effectiveness of Antibiotic Prophylaxis in Children With a Previous Urinary Tract Infection Unknown status NCT00156546 Phase 4
16 Study to Assess the Incidence of Local Oropharyngeal and Laryngeal Adverse Effects of Advair DISKUS 250/50 Mcg BID Unknown status NCT00235053 Phase 4
17 Study of Long-Term Use of Proton-Pump-Inhibitors in General Practice Unknown status NCT00363701 Phase 4
18 Role of Mosapride in Patients With Gastroesophageal Reflux Disease Completed NCT00729339 Phase 4
19 Dexlansoprazole in Asian Participants With Gastroesophageal Reflux Disease Completed NCT02351960 Phase 4
20 Determination of the Minimal Clinically Important Difference After Treatment With Pantoprazole in Patients With Symptoms of Acid Reflux (Gastroesophageal Reflux Disease) (BY1023/M3-340) Completed NCT00246909 Phase 4
21 Local Phase IV, Gastroesophageal Reflux Disease (GERD) Sleep Study US Completed NCT00660660 Phase 4
22 Practice and Patient Compliance on the PPI (Proton Pump Inhibitors) Treatment of Gastroesophageal Reflux in South Korea Completed NCT01018160 Phase 4
23 Study Comparing the Effects of Esomeprazole Adminstered Orally and Intravenously on Basal and Pentrigastrin-stimulated Acid Output in Subjects With Symptoms of Gastroesophageal Reflux Disease (GERD) Completed NCT00625495 Phase 4
24 An Efficacy Study to Compare the Treatment Effects of Rabeprazole and Lansoprazole Depending on the Genotyping of CYP2C19 in Treating Reflux Esophagitis Completed NCT01008696 Phase 4
25 A Study of Nexium (Esomeprazole) 40 mg Once Daily in Subjects With Symptoms of Gastroesophageal Reflux Disease (GORD) After Treatment With a Full Dose of Proton Pump Inhibitor (PPI) Completed NCT00734097 Phase 4
26 Safety and Efficacy of Lansoprazole in Patients With Reflux Disease Completed NCT01135368 Phase 4
27 Esomeprazole and Gastric Emptying of Beer Completed NCT00472550 Phase 4
28 A Multicenter, Randomized, Double-Blind, Placebo-Controlled Efficacy Study Comparing 4 Weeks of Treatment With Esomeprazole 20 mg qd and 40 mg qd to Placebo qd in Patients With Heartburn and Sleep Disturbances Associated With Gastroesophageal Reflux Disea Completed NCT00628342 Phase 4
29 On Demand Treatment of Reflux Disease Completed NCT00184522 Phase 4
30 A Study of the Safety of Rabeprazole Administered to Adults With Gastroesophageal Reflux Disease (GERD) Completed NCT00216489 Phase 4
31 Sleep Disorders and Gastroesophageal Reflux Disease (GERD) Completed NCT00287391 Phase 4
32 Do Laryngeal Tissue Changes in Patients Suspected of Having Laryngopharyngeal Reflux Predict Response to Treatment? Completed NCT00444145 Phase 4
33 Observational Study (This Means That no Drug is Tested) in Patients Suffering of Gastroesophageal Reflux Disease. Completed NCT01601379 Phase 4
34 An Open, Randomized, Two Way Crossover Study Comparing the Effect of 20mg Esomeprazole Administered Orally and Intravenously as a 15 Minute Infusion on Basal and Pentagastrin-Stimulated Acid Output in Subjects With Symptoms of Gastroesophageal Reflux Dise Completed NCT00629564 Phase 4
35 Omeprazole 20 mg in Patients With Laryngopharyngeal reflux and Comorbid Chronic Rhinosinusitis Completed NCT03086070 Phase 4
36 The Role of Anti-Reflux Surgery for Gastroesophageal Reflux Disease in Premature Infants With Bronchopulmonary Dysplasia Completed NCT00926276 Phase 4
37 Study Comparing Esomeprazole Magnesium 40mg Once Daily Versus Lansoprazole 30 mg Twice Daily in Symptom Control of Subjects With Persistent Gastrooesophageal Reflux Disease (GERD) Completed NCT00637845 Phase 4
38 Open, Randomized, Two Way Crossover Study Comparing the Effect of Esomeprazole Adminstered Orally and iv Completed NCT00626262 Phase 4
39 Determination of a Questionnaire After Treatment With Pantoprazole at Full Dose and Half Dose in Adult Patients With Symptoms of Acid Reflux (Gastroesophageal Reflux Disease) (BY1023/UK-506) Completed NCT00261339 Phase 4
40 Study of Changes in Reflux Symptoms and Reflux Finding Score According to Rabeprazole Treatment Period Completed NCT00614536 Phase 4
41 A Study to Evaluate REbamiPide as an Adjuvant Regimen to Heal erosIve Reflux Esophagitis Completed NCT02755753 Phase 4
42 A Study of Rabeprazole and Pantoprazole on Stomach Acid and Esophageal Acid Exposure in Patients With Gastroesophageal Reflux Disease (GERD) and a History of Nighttime Heartburn Completed NCT00237367 Phase 4
43 Alginate-based Reflux Suppressant and Magnesium-aluminium Antacid Gel for Treatment of Heartburn in Pregnancy Completed NCT02470117 Phase 4
44 Nissen and Gastroplasty in Gastroesophageal Reflux Disease (GERD) Completed NCT00872755 Phase 4
45 Comparing Clinical Efficacy of One-Week Dual Delayed-Release Dexlansoprazole and Esomeprazole for GERD Grade A and B Completed NCT03128736 Phase 4
46 Esophageal and Laryngeal Tissue Changes in Patients Suspected of Having Laryngopharyngeal Reflux Completed NCT00373997 Phase 4
47 An Open-Label Study of Once-Daily Oral Administration of Esomeprazole 40 mg in Patients With Symptoms of Gastroesophageal Reflux Disease (GERD) Completed NCT00242736 Phase 4
48 Validation of RDQ Questionnaire Completed NCT00291746 Phase 4
49 Study to Assess Management Strategies for the Use of Esomeprazole (Nexium) in Helicobacter Pylori Infected Patients Completed NCT00574925 Phase 4
50 A Study to Compare the Number of Patients With Gastro-Oesophageal Reflux Disease (GORD) Achieving Heartburn and Regurgitation Symptom Resolution After Treatment With Either Rabeprazole Sodium 20mg, Esomeprazole 20mg or Esomeprazole 40mg Completed NCT00464308 Phase 4

Search NIH Clinical Center for Gastroesophageal Reflux

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: gastroesophageal reflux

Genetic Tests for Gastroesophageal Reflux

Genetic tests related to Gastroesophageal Reflux:

id Genetic test Affiliating Genes
1 Gastroesophageal Reflux 29

Anatomical Context for Gastroesophageal Reflux

MalaCards organs/tissues related to Gastroesophageal Reflux:

39
Kidney, Testes, Lung, T Cells, Liver, Colon, Tongue

Publications for Gastroesophageal Reflux

Articles related to Gastroesophageal Reflux:

(show top 50) (show all 920)
id Title Authors Year
1
Corrigendum: Natural History of Gastroesophageal Reflux Disease and Functional Abdominal Disorders: A Population-Based Study. ( 28534522 )
2017
2
Long-Term Results After Sleeve Gastrectomy for Gastroesophageal Reflux Disease: a Single-Center French Study. ( 28474318 )
2017
3
Gastroesophageal Reflux? ( 28062637 )
2017
4
Gastroesophageal Reflux Disease After Laparoscopic Sleeve Gastrectomy with Concomitant Hiatal Hernia Repair: an Unresolved Question. ( 28455802 )
2017
5
Factors Associated with Potassium-Competitive Acid Blocker Non-Response in Patients with Proton Pump Inhibitor-Refractory Gastroesophageal Reflux Disease. ( 28501868 )
2017
6
Impact of gastroesophageal reflux disease symptoms on the quality of life in pregnant women: a prospective study. ( 28471830 )
2017
7
Surgical Options for the Treatment of Gastroesophageal Reflux Disease. ( 28450820 )
2017
8
Correlation Between Symptom Severity and Health-Related Life Quality of a Population With Gastroesophageal Reflux Disease. ( 28496527 )
2017
9
Impact of gastroesophageal reflux control through tailored proton pump inhibition therapy or fundoplication in patients with Barrett's esophagus. ( 28533674 )
2017
10
Flavonoids from whole Plant of Euphorbia hirta and their Evaluation against Experimentally induced Gastroesophageal Reflux Disease in Rats. ( 28479737 )
2017
11
The Relationship of the Post-reflux Swallow-induced Peristaltic Wave Index and Esophageal Baseline Impedance with Gastroesophageal Reflux Disease Symptoms. ( 28044052 )
2017
12
Disintegrin and metalloproteinases (ADAMs) expression in gastroesophageal reflux disease and in esophageal adenocarcinoma. ( 27026568 )
2017
13
Gastroesophageal reflux after peroral endoscopic myotomy: a multicenter case-control study. ( 28472834 )
2017
14
Gastroesophageal Reflux Disease. ( 28502434 )
2017
15
Clinical Considerations of Silent Gastroesophageal Reflux Disease in Morbidly Obese Patients. ( 28452206 )
2017
16
The Changing Impact of Gastroesophageal Reflux Disease in Clinical Practice. ( 28073299 )
2017
17
Laparoscopic revision surgery for gastroesophageal reflux disease. ( 28072725 )
2017
18
Histopathological Findings Associated With Gastroesophageal Reflux Disease and Aspiration After Lung Transplantation: Initial Brazilian Single-Center Experience. ( 28457418 )
2017
19
Self-rated health and functional capacity in individuals reporting overlapping symptoms of gastroesophageal reflux disease, functional dyspepsia and irritable bowel syndrome - a population based study. ( 28521729 )
2017
20
Role of gastroesophageal reflux disease in lung transplantation. ( 28507913 )
2017
21
The Degree of Disease Knowledge in Patients with Gastroesophageal Reflux Disease: A Multi-center Prospective Study in Korea. ( 28478662 )
2017
22
Quality of Life 1A Year After Laparoscopic Sleeve Gastrectomy Versus Laparoscopic Roux-en-Y Gastric Bypass: a Randomized Controlled Trial Focusing on Gastroesophageal Reflux Disease. ( 28474319 )
2017
23
Efficacy of Magnetic Sphincter Augmentation versus Nissen Fundoplication for Gastroesophageal Reflux Disease in Short Term: A Meta-Analysis. ( 28466002 )
2017
24
Surgical Treatment of Extraesophageal Manifestations of Gastroesophageal Reflux Disease. ( 28508234 )
2017
25
Quality of life, patient satisfaction, and disease burden in patients with gastroesophageal reflux disease with or without laryngopharyngeal reflux symptoms. ( 28052406 )
2017
26
The Effect of Acute Stress on Esophageal Motility and Gastroesophageal Reflux in Healthy Humans. ( 28049863 )
2017
27
Human leukocyte antigen HLADRB1 determinants susceptibility to gastroesophageal reflux disease. ( 28079238 )
2017
28
Food and Gastroesophageal Reflux Disease. ( 28521699 )
2017
29
Gastroesophageal Reflux and Sleep Disturbances: A Bidirectional Association in a Population-Based Cohort Study, The HUNT Study. ( 27166240 )
2016
30
Electroacupuncture to treat gastroesophageal reflux disease: study protocol for a randomized controlled trial. ( 27188910 )
2016
31
24-h Multichannel Intraluminal Impedance PH-metry 1A Year After Laparocopic Sleeve Gastrectomy: an Objective Assessment of Gastroesophageal Reflux Disease. ( 27592124 )
2016
32
Dietary habits and gastroesophageal reflux disease in preschool children. ( 27588031 )
2016
33
A Modern Magnetic Implant for Gastroesophageal Reflux Disease (GERD). ( 28025156 )
2016
34
Prospective Controlled Study of Gastroesophageal Reflux in Dogs with Naturally Occurring Laryngeal Paralysis. ( 27611104 )
2016
35
Diagnosis and treatment of gastroesophageal reflux disease: recommendations of the AsociaciA^n Mexicana de GastroenterologA-a. ( 27595382 )
2016
36
The impact of the speed of food intake on gastroesophageal reflux events in obese female patients. ( 27630010 )
2016
37
Medical cost, incidence rate and treatment status of gastroesophageal reflux disease in Japan: analysis of claims data. ( 27207316 )
2016
38
Randomized, multicenter study: on-demand versus continuous maintenance treatment with esomeprazole in patients with non-erosive gastroesophageal reflux disease. ( 27080034 )
2016
39
Prevalence of dental erosion among people with gastroesophageal reflux disease in China. ( 27616724 )
2016
40
A New Algorithm to Reduce the Incidence of Gastroesophageal Reflux Symptoms after Laparoscopic Sleeve Gastrectomy. ( 28013451 )
2016
41
Rapid progressive long esophageal stricture caused by gastroesophageal reflux disease after pylorus-preserving pancreatoduodenectomy. ( 27090811 )
2016
42
Gastroesophageal reflux disease-related and functional heartburn: pathophysiology and treatment. ( 27206157 )
2016
43
Oesophageal disease: gastroesophageal reflux disease, Barrett's oesophagus, achalasia and eosinophilic oesophagitis. ( 27888864 )
2016
44
Efficacy of acid suppression therapy in gastroesophageal reflux disease-related chronic laryngitis. ( 27749540 )
2016
45
Association between follicular tracheitis and gastroesophageal reflux. ( 26857306 )
2016
46
Gastroesophageal reflux and COPD exacerbations: Is cholinergic-mediated oesophago-bronchial reflex a possible link? - Reply. ( 27634594 )
2016
47
Medicinal Plants for Management of Gastroesophageal Reflux Disease: A Review of Animal and Human Studies. ( 27996295 )
2016
48
The Quality of Care for Gastroesophageal Reflux Disease. ( 28028689 )
2016
49
Roux-en-Y gastric bypass for obesity after Belsey-Mark IV for large hiatus hernia and intrathoracic stomach, in combination with gastroesophageal reflux disease. ( 27414636 )
2016
50
LINX(Ar) magnetic esophageal sphincter augmentation versus Nissen fundoplication for gastroesophageal reflux disease: a systematic review and meta-analysis. ( 27981382 )
2016

Variations for Gastroesophageal Reflux

Expression for Gastroesophageal Reflux

Search GEO for disease gene expression data for Gastroesophageal Reflux.

Pathways for Gastroesophageal Reflux

GO Terms for Gastroesophageal Reflux

Cellular components related to Gastroesophageal Reflux according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.76 CCK CCL26 CXCL8 GAST GHRL IL1B
2 extracellular space GO:0005615 9.17 CCK CCL26 CXCL8 GAST GHRL IL1B
3 organelle membrane GO:0031090 9.13 CYP2C19 PTGS1 PTGS2

Biological processes related to Gastroesophageal Reflux according to GeneCards Suite gene sharing:

(show all 16)
id Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.97 CCK CCL26 CXCL8 F2RL1 GAST HRH2
2 movement of cell or subcellular component GO:0006928 9.58 CXCL8 PTGS2 PYY
3 prostaglandin metabolic process GO:0006693 9.56 PTGS1 PTGS2
4 positive regulation of NF-kappaB import into nucleus GO:0042346 9.55 IL1B PTGS2
5 positive regulation of interleukin-6 secretion GO:2000778 9.54 F2RL1 IL1B
6 positive regulation of protein export from nucleus GO:0046827 9.52 IL1B TP53
7 prostaglandin biosynthetic process GO:0001516 9.51 PTGS1 PTGS2
8 G-protein coupled receptor signaling pathway GO:0007186 9.5 CCL26 CXCL8 F2RL1 GAST GHRL HRH2
9 positive regulation of protein oligomerization GO:0032461 9.49 CCK TP53
10 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.48 F2RL1 IL1B
11 cyclooxygenase pathway GO:0019371 9.46 PTGS1 PTGS2
12 positive regulation of chemotaxis GO:0050921 9.43 CCL26 F2RL1
13 neutrophil chemotaxis GO:0030593 9.43 CCL26 CXCL8 IL1B
14 neutrophil activation GO:0042119 9.32 CXCL8 F2RL1
15 positive regulation of fever generation GO:0031622 9.16 IL1B PTGS2
16 inflammatory response GO:0006954 9.1 CCL26 CXCL8 F2RL1 IL1B PTGS1 PTGS2

Molecular functions related to Gastroesophageal Reflux according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.43 CYP2C19 PTGS1 PTGS2
2 neuropeptide hormone activity GO:0005184 9.33 CCK NTS PYY
3 prostaglandin-endoperoxide synthase activity GO:0004666 8.96 PTGS1 PTGS2
4 hormone activity GO:0005179 8.92 CCK GAST GHRL PYY

Sources for Gastroesophageal Reflux

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
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