GERD
MCID: GST034
MIFTS: 66

Gastroesophageal Reflux Disease (GERD) malady

Gastrointestinal diseases category
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Summaries for Gastroesophageal Reflux Disease

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MedlinePlus:33 Your esophagus is the tube that carries food from your mouth to your stomach. gastroesophageal reflux disease (gerd) happens when a muscle at the end of your esophagus does not close properly. this allows stomach contents to leak back, or reflux, into the esophagus and irritate it. you may feel a burning in the chest or throat called heartburn. sometimes, you can taste stomach fluid in the back of the mouth. if you have these symptoms more than twice a week, you may have gerd. you can also have gerd without having heartburn. your symptoms could include a dry cough, asthma symptoms, or trouble swallowing. anyone, including infants and children, can have gerd. if not treated, it can lead to more serious health problems. in some cases, you might need medicines or surgery. however, many people can improve their symptoms by avoiding alcohol and spicy, fatty or acidic foods that trigger heartburn eating smaller meals not eating close to bedtime losing weight if needed wearing loose-fitting clothes nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Gastroesophageal Reflux Disease, also known as gastroesophageal reflux, is related to esophagitis and dyspepsia, and has symptoms including An important gene associated with Gastroesophageal Reflux Disease is GER (Gastroesophageal reflux), and among its related pathways are Gastrin-CREB signalling pathway via PKC and MAPK and Signaling by GPCR. The drugs sodium bicarbonate and sodium bicarbonate powder and the compounds enterogastrone and asperlicin have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and lung, and related mouse phenotypes are behavior/neurological and nervous system.

Wikipedia:65 Gastroesophageal reflux disease (GERD), gastro-oesophageal reflux disease (GORD), gastric reflux... more...

Description from OMIM:46 109350

Aliases & Classifications for Gastroesophageal Reflux Disease

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Gastroesophageal Reflux Disease, Aliases & Descriptions:

Name: Gastroesophageal Reflux Disease 8 10 44 62
Gastroesophageal Reflux 8 9 46
Gerd - Gastro-Esophageal Reflux Disease 8 62
Gerd 8 33
 
Gastro-Esophageal Reflux 8
Gastresophageal Reflux 8
Acid Reflux 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology8 DOID:8534
MeSH34 D005764
NCIt39 C26781
ICD9CM27 530.81
OMIM46 109350

Related Diseases for Gastroesophageal Reflux Disease

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Diseases related to Gastroesophageal Reflux Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 265)
idRelated DiseaseScoreTop Affiliating Genes
1esophagitis31.8CYP2C19, NTS, HRH2
2dyspepsia31.3CCK, HRH2
3irritable bowel syndrome31.2CCK
4morbid obesity30.9PYY, CCK
5duodenal ulcer30.8HRH2, SCT
6gastric ulcer30.8CYP2C19, HRH2
7asthma30.7SCT, NTS, HRH2
8obesity30.7PYY, CCK, CCKAR, NTS
9zollinger-ellison syndrome30.6HRH2, SCT
10dumping syndrome30.5PYY, NTS
11bulimia nervosa30.4PYY, CCK
12duodenogastric reflux30.3CCK, NTS
13constipation30.3PYY, CCK
14peptic ulcer disease30.2HRH2, CCK, SCT, CYP2C19
15celiac disease30.2CCK, PYY
16adenocarcinoma30.2NTS, CCKAR, CCK, SCT, PYY
17diabetes mellitus30.1CCKAR, CCK, SCT, PYY
18parkinson's disease30.0HRH2, NTS, CCKAR, CYP2C19
19gastritis29.5CYP2C19, SCT, CCK, NTS, HRH2
20type 2 diabetes mellitus29.4NTS, CCKAR, CCK, SCT, PYY
21barrett's esophagus10.8
22eosinophilic esophagitis10.7
23laryngitis10.6
24hiatus hernia10.6
25obstructive sleep apnea10.5
26bile reflux10.5
27sleep apnea10.5
28chronic obstructive pulmonary disease10.5
29bruxism10.5
30tooth erosion10.5
31blindness10.5
32eating disorder10.4PYY
33atrophic gastritis10.4
34laryngomalacia10.4
35achalasia10.4
36duodenitis10.4
37pulmonary function10.4
38h. pylori infection10.3
39hereditary sensory and autonomic neuropathy type 1b10.3
40arthritis10.3
41bronchiolitis obliterans10.3
42rheumatoid arthritis10.3
43bronchiolitis10.3
44eosinophilia10.3
45neuropathy10.3
46chronic hiccups10.3
47barrett's adenocarcinoma10.3
48ehlers-danlos syndrome10.3
49ehlers-danlos syndrome type iv10.3
50esophageal cancer10.3

Graphical network of the top 20 diseases related to Gastroesophageal Reflux Disease:



Diseases related to gastroesophageal reflux disease

Symptoms for Gastroesophageal Reflux Disease

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Clinical features from OMIM:

109350

HPO human phenotypes related to Gastroesophageal Reflux Disease:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 abnormality of metabolism/homeostasis HP:0001939
3 gastroesophageal reflux HP:0002020
4 neoplasm HP:0002664
5 esophagitis HP:0100633

Genetic Tests for Gastroesophageal Reflux Disease

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Anatomical Context for Gastroesophageal Reflux Disease

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MalaCards organs/tissues related to Gastroesophageal Reflux Disease:

32
Kidney, Testes, Lung, T cells, Cortex, Heart, Colon, Liver, Tongue

Animal Models for Gastroesophageal Reflux Disease or affiliated genes

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MGI Mouse Phenotypes related to Gastroesophageal Reflux Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053867.7HRH2, NTS, CCKAR, SCT, PYY
2MP:00036317.1HRH2, NTS, CCKAR, CCK, SCT, PYY
3MP:00053766.9PYY, SCT, CCK, CCKAR, NTS, HRH2

Publications for Gastroesophageal Reflux Disease

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Articles related to Gastroesophageal Reflux Disease:

(show top 50)    (show all 613)
idTitleAuthorsYear
1
Acidic and neutral liquid ingestion in patients with gastroesophageal reflux disease. (25296082)
2014
2
The effects of baclofen for the treatment of gastroesophageal reflux disease: a meta-analysis of randomized controlled trials. (25389436)
2014
3
Does laparoscopic sleeve gastrectomy have any influence on gastroesophageal reflux disease? Preliminary results. (25303918)
2014
4
Risk factors for gastroesophageal reflux disease: the role of diet. (25396005)
2014
5
Association of sleep dysfunction and emotional status with gastroesophageal reflux disease in Korea. (23875102)
2013
6
Gastroesophageal reflux disease. (23853605)
2013
7
The value of early wireless esophageal pH monitoring in diagnosing functional heartburn in refractory gastroesophageal reflux disease. (23765257)
2013
8
Halitosis and tongue coating in patients with erosive gastroesophageal reflux disease versus nonerosive gastroesophageal reflux disease. (22437377)
2013
9
Systematic review of patient-reported outcome instruments for gastroesophageal reflux disease symptoms. (23202695)
2013
10
Rabeprazole 10 mg versus 20 mg in preventing relapse of gastroesophageal reflux disease: a meta-analysis. (23981627)
2013
11
Laparoscopic anterior 180-degree versus nissen fundoplication for gastroesophageal reflux disease: systematic review and meta-analysis of randomized clinical trials. (23470572)
2013
12
Relationships between sleep disturbances and gastroesophageal reflux disease in Asian sleep clinic referrals. (24290045)
2013
13
Sleep disturbances and refractory gastroesophageal reflux disease symptoms in patients receiving once-daily proton pump inhibitors and efficacy of twice-daily rabeprazole treatment. (24008338)
2013
14
High-resolution Manometry and Globus: Comparison of Globus, Gastroesophageal Reflux Disease and Normal Controls Using High-resolution Manometry. (24199007)
2013
15
Lifestyle characteristics and gastroesophageal reflux disease: a population-based study in Albania. (23509449)
2013
16
Dental findings of gastroesophageal reflux disease and treatment planning. (23794348)
2013
17
Long-term results of electrical stimulation of the lower esophageal sphincter for the treatment of gastroesophageal reflux disease. (23881803)
2013
18
Symptoms of gastroesophageal reflux disease improve after parathyroidectomy. (23158189)
2012
19
Gastroesophageal reflux disease--from reflux episodes to mucosal inflammation. (22105108)
2012
20
Oral symptoms including dental erosion in gastroesophageal reflux disease are associated with decreased salivary flow volume and swallowing function. (22200941)
2012
21
Assessment of desmosomal components (desmoglein 1-3, plakoglobin) in cardia mucosa in relation to gastroesophageal reflux disease and Helicobacter pylori infection. (22521077)
2012
22
The effect of Helicobacter pylori on gastroesophageal reflux disease. (23477175)
2012
23
A prospective multicenter registry of patients with chronic gastroesophageal reflux disease receiving transoral incisionless fundoplication. (22939637)
2012
24
Bravo 48-hour Wireless pH Monitoring in Patients With Non-cardiac Chest Pain. Objective Gastroesophageal Reflux Disease Parameters Predict the Responses to Proton Pump Inhibitors. (22523725)
2012
25
Frequency and clinical implications of supraesophageal and dyspeptic symptoms in gastroesophageal reflux disease. (22330237)
2012
26
Extraesophageal manifestations of gastroesophageal reflux disease: cough, asthma, laryngitis, chest pain. (22442097)
2012
27
Comparison of central and intraesophageal factors between gastroesophageal reflux disease (GERD) patients and those with GERD-related noncardiac chest pain. (22309285)
2012
28
Single nucleotide polymorphisms in the matrix metalloproteinase gene family and the frequency and duration of gastroesophageal reflux disease influence the risk of esophageal adenocarcinoma. (22422400)
2012
29
Transoral incisionless fundoplication for treatment of gastroesophageal reflux disease in clinical practice. (22648098)
2012
30
Gastroesophageal reflux disease: another risk factor for atrial fibrillation? (22261930)
2011
31
Cow's Milk Allergy among Children with Gastroesophageal Reflux Disease. (21927657)
2011
32
Comparison of presentation and impact on quality of life of gastroesophageal reflux disease between young and old adults in a Chinese population. (22147968)
2011
33
Treatment of gastroesophageal reflux disease: a call for increase awareness and local research. (21465947)
2011
34
The value of Carlsson-dent questionnaire in diagnosis of gastroesophageal reflux disease in area with low prevalence of gastroesophageal reflux disease. (21602993)
2011
35
Symptom indexes in refractory gastroesophageal reflux disease: overrated or misunderstood? (21791195)
2011
36
Control of intragastric pH and its relationship to gastroesophageal reflux disease outcomes. (21694609)
2011
37
Prevalence of broncopulmonary and otorhinolaryngologic symptoms in children under investigation for gastroesophageal reflux disease: retrospective analysis. (21739007)
2011
38
Expression pattern of cathepsin W isoforms in peripheral blood and gastroesophageal mucosa of patients with gastroesophageal reflux disease. (22050231)
2011
39
Genetic factors in the pathogenesis of gastroesophageal reflux disease. (21562717)
2011
40
Do eosinophil numbers differentiate eosinophilic esophagitis from gastroesophageal reflux disease? (20524860)
2010
41
Menkes disease with gastroesophageal reflux disease and successful surgical treatment: a case report and literature review. (20718197)
2010
42
Prevalence of bile reflux in gastroesophageal reflux disease patients not responsive to proton pump inhibitors. (19140233)
2009
43
Comorbidities in severe asthma: frequency of rhinitis, nasal polyposis, gastroesophageal reflux disease, vocal cord dysfunction and bronchiectasis. (19690661)
2009
44
Gastric ulcer after laparoscopic fundoplication for gastroesophageal reflux disease: significance of the eradication of Helicobacter pylori. (17581465)
2007
45
Gastroesophageal Reflux Disease (GERD) (21919262)
2005
46
Gastroesophageal reflux disease, tooth erosion, and prosthodontic rehabilitation: a clinical report. (15061234)
2003
47
Relationship of sliding hiatus hernia to gastroesophageal reflux disease: a possible role for Helicobacter pylori infection? (12643607)
2003
48
Effect of cytochrome P4502C19 genotypic differences on cure rates for gastroesophageal reflux disease by lansoprazole. (12386647)
2002
49
Head and neck manifestations of gastroesophageal reflux disease. (10498113)
1999
50
Complications of gastroesophageal reflux disease. Role of the lower esophageal sphincter, esophageal acid and acid/alkaline exposure, and duodenogastric reflux. (1632700)
1992

Variations for Gastroesophageal Reflux Disease

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Expression for genes affiliated with Gastroesophageal Reflux Disease

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Expression patterns in normal tissues for genes affiliated with Gastroesophageal Reflux Disease

Search GEO for disease gene expression data for Gastroesophageal Reflux Disease.

Pathways for genes affiliated with Gastroesophageal Reflux Disease

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Compounds for genes affiliated with Gastroesophageal Reflux Disease

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Compounds related to Gastroesophageal Reflux Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 120)
idCompoundScoreTop Affiliating Genes
1enterogastrone449.8PYY, CCK
2asperlicin449.7CCKAR, CCK
3epft449.6SCT, CCK
41,4-benzodiazepine449.6CCKAR, CCK
5dexloxiglumide44 2810.6CCKAR, CCK
6ym022449.5CCK, CCKAR
7cisapride44 28 1111.5HRH2, CCK, CYP2C19
8lorglumide44 2810.5CCK, CCKAR
9benzodiazepines449.5CCK, HRH2, CCKAR
10l365260449.4CCKAR, CCK
11intralipid449.4PYY, CCK, CCKAR
12pepsinogen449.4CCK, HRH2, SCT
13cimetidine44 28 1111.3CYP2C19, SCT, HRH2
14caerulein449.2CCKAR, CCK, SCT
15diphenhydramine44 28 2 24 1113.2CYP2C19, NTS, HRH2
16acetaminophen44 2 50 24 1113.1PYY, CYP2C19, CCK, HRH2
17amphetamine44 50 1111.0CCK, NTS, PYY
18benzodiazepine449.0CCKAR, CCK, NTS
19ranitidine44 28 24 1111.9HRH2, CCK, SCT, CYP2C19
20clonidine44 50 28 1111.9SCT, NTS, PYY
215-hydroxytryptamine448.7PYY, HRH2, NTS, CCK
22propranolol44 28 50 24 1112.7SCT, PYY, CYP2C19
23opiate448.7CCK, NTS, HRH2
24haloperidol44 50 28 2 1112.7NTS, PYY, CCKAR, CYP2C19
25amine448.6NTS, SCT, PYY, HRH2
26isoproterenol44 119.6PYY, SCT, HRH2, NTS
27cocaine44 119.6NTS, PYY, CCKAR, CCK
28bicarbonate448.6HRH2, SCT, CCK, NTS
29oxyntomodulin44 619.5SCT, NTS, CCK, PYY
30c-peptide448.5NTS, SCT, CCK, PYY
31oleic acid44 28 24 1111.5NTS, PYY, CCKAR, SCT
32carbachol44 28 1110.5NTS, SCT, CCK, PYY
33guanine44 24 1110.5NTS, CCKAR, HRH2, SCT
34loxiglumide448.4CCKAR, NTS, CCK, SCT
35acth448.4PYY, NTS, CCK, SCT
36indomethacin44 28 61 1111.4CYP2C19, CCKAR, SCT, NTS
37norepinephrine44 24 1110.3NTS, CCK, SCT, PYY
38ethanol44 50 24 1111.2SCT, NTS, HRH2, PYY, CYP2C19
39histamine44 28 2410.1NTS, HRH2, PYY, SCT, CCK
40acetylcholine44 50 28 24 1112.1PYY, SCT, CCK, NTS, HRH2
41cyclic amp44 249.1PYY, SCT, CCKAR, NTS, HRH2
42omeprazole44 50 28 24 1112.0HRH2, SCT, CYP2C19, PYY, CCKAR, CCK
43octreotide44 61 28 1111.0CCKAR, PYY, CCK, SCT, NTS
44gaba448.0NTS, PYY, SCT, CCK, CCKAR
45atropine44 28 119.7HRH2, NTS, CCKAR, CCK, SCT, PYY
46tetrodotoxin44 61 289.7NTS, HRH2, CCKAR, CCK, SCT, PYY
47lipid447.6NTS, SCT, HRH2, CCKAR, CYP2C19, PYY
48glucose447.6NTS, CCK, SCT, PYY, CCKAR
49dopamine44 28 24 1110.6SCT, PYY, CYP2C19, NTS, CCK, CCKAR
50tyrosine447.4CYP2C19, CCKAR, PYY, SCT, NTS, CCK

GO Terms for genes affiliated with Gastroesophageal Reflux Disease

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Cellular components related to Gastroesophageal Reflux Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.1NTS, CCK, SCT, PYY

Biological processes related to Gastroesophageal Reflux Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1eating behaviorGO:0427559.7CCK, PYY
2feeding behaviorGO:0076319.6CCKAR, PYY
3visual learningGO:0085429.5HRH2, SCT
4digestionGO:0075869.4PYY, CCKAR
5neuron migrationGO:0017649.4CCKAR, CCK
6axonogenesisGO:0074099.1CCKAR, CCK

Molecular functions related to Gastroesophageal Reflux Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051798.9CCK, SCT, PYY
2neuropeptide hormone activityGO:0051848.4NTS, CCK, PYY

Products for genes affiliated with Gastroesophageal Reflux Disease

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Sources for Gastroesophageal Reflux Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet