GERD
MCID: GST034
MIFTS: 64

Gastroesophageal Reflux Disease (GERD) malady

Gastrointestinal diseases category

Summaries for Gastroesophageal Reflux Disease

About this section
Sources:
35MedlinePlus, 66Wikipedia, 48OMIM, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
MedlinePlus:35 Your esophagus is the tube that carries food from your mouth to your stomach. gastroesophageal reflux disease (gerd) happens when a muscle at the end of your esophagus does not close properly. this allows stomach contents to leak back, or reflux, into the esophagus and irritate it. you may feel a burning in the chest or throat called heartburn. sometimes, you can taste stomach fluid in the back of the mouth. if you have these symptoms more than twice a week, you may have gerd. you can also have gerd without having heartburn. your symptoms could include a dry cough, asthma symptoms, or trouble swallowing. anyone, including infants and children, can have gerd. if not treated, it can lead to more serious health problems. in some cases, you might need medicines or surgery. however, many people can improve their symptoms by avoiding alcohol and spicy, fatty or acidic foods that trigger heartburn eating smaller meals not eating close to bedtime losing weight if needed wearing loose-fitting clothes nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Gastroesophageal Reflux Disease, also known as gastroesophageal reflux, is related to esophagitis and obesity. An important gene associated with Gastroesophageal Reflux Disease is GER (Gastroesophageal reflux), and among its related pathways are Gastrin-CREB signalling pathway via PKC and MAPK and Signaling by GPCR. The drugs aluminum hydroxide and aluminum hydroxide gel and the compounds enterogastrone and asperlicin have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and lung, and related mouse phenotypes are behavior/neurological and nervous system.

Wikipedia:66 Gastroesophageal reflux disease (GERD), gastro-oesophageal reflux disease (GORD), gastric reflux... more...

Description from OMIM:48 109350

Aliases & Classifications for Gastroesophageal Reflux Disease

About this section
Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 35MedlinePlus, 10diseasecard, 48OMIM, 41NCIt, 59SNOMED-CT, 36MeSH, 28ICD9CM
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

gastroesophageal reflux disease 9 11 46 63
gastroesophageal reflux 9 10 48
gerd 9 35
gerd - gastro-esophageal reflux disease 9
gastro-esophageal reflux 9
gastresophageal reflux 9
acid reflux 9


External Ids:

Disease Ontology9 DOID:8534
NCIt41 C26781
MeSH36 D005764
OMIM48 109350
ICD9CM28 530.81

Related Diseases for Gastroesophageal Reflux Disease

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases related to Gastroesophageal Reflux Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 265)
idRelated DiseaseScoreTop Affiliating Genes
1esophagitis31.7CYP2C19, NTS, HRH2
2obesity31.1PYY, CCK, CCKAR, NTS
3dyspepsia31.1CCK, HRH2
4irritable bowel syndrome30.9CCK
5asthma30.9SCT, NTS, HRH2
6adenocarcinoma30.8NTS, CCKAR, CCK, SCT, PYY
7morbid obesity30.8PYY, CCK
8diabetes mellitus30.5CCKAR, CCK, SCT, PYY
9duodenal ulcer30.5HRH2, SCT
10gastric ulcer30.5CYP2C19, HRH2
11peptic ulcer disease30.3HRH2, CCK, SCT, CYP2C19
12zollinger-ellison syndrome30.3HRH2, SCT
13bulimia nervosa30.2PYY, CCK
14dumping syndrome30.2PYY, NTS
15duodenogastric reflux30.2CCK, NTS
16celiac disease30.2CCK, PYY
17constipation30.2PYY, CCK
18parkinson's disease30.1HRH2, NTS, CCKAR, CYP2C19
19gastritis30.0CYP2C19, SCT, CCK, NTS, HRH2
20type 2 diabetes mellitus30.0NTS, CCKAR, CCK, SCT, PYY
21barrett's esophagus10.8
22eosinophilic esophagitis10.7
23laryngitis10.6
24bile reflux10.5
25hiatus hernia10.5
26obstructive sleep apnea10.4
27sleep apnea10.4
28tooth erosion10.4
29blindness10.4
30bruxism10.4
31duodenitis10.4
32neuropathy10.4
33pulmonary function10.4
34hereditary sensory and autonomic neuropathy type 1b10.3
35bronchiolitis10.3
36bronchiolitis obliterans10.3
37achalasia10.3
38arthritis10.3
39eosinophilia10.3
40rheumatoid arthritis10.3
41chronic hiccups10.3
42barrett's adenocarcinoma10.3
43ehlers-danlos syndrome10.3
44ehlers-danlos syndrome type iv10.3
45intrinsic asthma10.2
46type i ehlers-danlos syndrome10.2
47pyloric stenosis10.2
48systemic scleroderma10.2
49pierre robin sequence10.2
50sandifer syndrome10.2

Graphical network of the top 20 diseases related to Gastroesophageal Reflux Disease:



Diseases related to gastroesophageal reflux disease

Symptoms for Gastroesophageal Reflux Disease

About this section
Sources:
48OMIM
See all sources


Clinical features from OMIM:

109350

Drugs & Therapeutics for Gastroesophageal Reflux Disease

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Genetic Tests for Gastroesophageal Reflux Disease

About this section

Anatomical Context for Gastroesophageal Reflux Disease

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Gastroesophageal Reflux Disease:

34
Kidney, Testes, Lung, T cells, Liver, Tongue, Heart, Colon

Animal Models for Gastroesophageal Reflux Disease or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Gastroesophageal Reflux Disease:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053867.7HRH2, NTS, CCKAR, SCT, PYY
2MP:00036317.1HRH2, NTS, CCKAR, CCK, SCT, PYY
3MP:00053766.9PYY, SCT, CCK, CCKAR, NTS, HRH2

Publications for Gastroesophageal Reflux Disease

About this section
Sources:
53PubMed
See all sources

Articles related to Gastroesophageal Reflux Disease:

(show top 50)    (show all 589)
idTitleAuthorsYear
1
Association of sleep dysfunction and emotional status with gastroesophageal reflux disease in Korea. (23875102)
2013
2
Gastroesophageal reflux disease. (23853605)
2013
3
The value of early wireless esophageal pH monitoring in diagnosing functional heartburn in refractory gastroesophageal reflux disease. (23765257)
2013
4
Halitosis and tongue coating in patients with erosive gastroesophageal reflux disease versus nonerosive gastroesophageal reflux disease. (22437377)
2013
5
Systematic review of patient-reported outcome instruments for gastroesophageal reflux disease symptoms. (23202695)
2013
6
Rabeprazole 10 mg versus 20 mg in preventing relapse of gastroesophageal reflux disease: a meta-analysis. (23981627)
2013
7
Laparoscopic anterior 180-degree versus nissen fundoplication for gastroesophageal reflux disease: systematic review and meta-analysis of randomized clinical trials. (23470572)
2013
8
Relationships between sleep disturbances and gastroesophageal reflux disease in Asian sleep clinic referrals. (24290045)
2013
9
Sleep disturbances and refractory gastroesophageal reflux disease symptoms in patients receiving once-daily proton pump inhibitors and efficacy of twice-daily rabeprazole treatment. (24008338)
2013
10
High-resolution Manometry and Globus: Comparison of Globus, Gastroesophageal Reflux Disease and Normal Controls Using High-resolution Manometry. (24199007)
2013
11
Lifestyle characteristics and gastroesophageal reflux disease: a population-based study in Albania. (23509449)
2013
12
Dental findings of gastroesophageal reflux disease and treatment planning. (23794348)
2013
13
Long-term results of electrical stimulation of the lower esophageal sphincter for the treatment of gastroesophageal reflux disease. (23881803)
2013
14
Changes in ghrelin-related factors in gastroesophageal reflux disease in rats. (23653638)
2013
15
Endoscopic grading of the gastroesophageal flap valve is correlated with reflux activity and can predict the size of the esophageal hiatus in patients with gastroesophageal reflux disease. (23846367)
2013
16
Symptoms of gastroesophageal reflux disease improve after parathyroidectomy. (23158189)
2012
17
Gastroesophageal reflux disease--from reflux episodes to mucosal inflammation. (22105108)
2012
18
Oral symptoms including dental erosion in gastroesophageal reflux disease are associated with decreased salivary flow volume and swallowing function. (22200941)
2012
19
Assessment of desmosomal components (desmoglein 1-3, plakoglobin) in cardia mucosa in relation to gastroesophageal reflux disease and Helicobacter pylori infection. (22521077)
2012
20
The effect of Helicobacter pylori on gastroesophageal reflux disease. (23477175)
2012
21
A prospective multicenter registry of patients with chronic gastroesophageal reflux disease receiving transoral incisionless fundoplication. (22939637)
2012
22
Bravo 48-hour Wireless pH Monitoring in Patients With Non-cardiac Chest Pain. Objective Gastroesophageal Reflux Disease Parameters Predict the Responses to Proton Pump Inhibitors. (22523725)
2012
23
Frequency and clinical implications of supraesophageal and dyspeptic symptoms in gastroesophageal reflux disease. (22330237)
2012
24
Extraesophageal manifestations of gastroesophageal reflux disease: cough, asthma, laryngitis, chest pain. (22442097)
2012
25
Comparison of central and intraesophageal factors between gastroesophageal reflux disease (GERD) patients and those with GERD-related noncardiac chest pain. (22309285)
2012
26
Single nucleotide polymorphisms in the matrix metalloproteinase gene family and the frequency and duration of gastroesophageal reflux disease influence the risk of esophageal adenocarcinoma. (22422400)
2012
27
Transoral incisionless fundoplication for treatment of gastroesophageal reflux disease in clinical practice. (22648098)
2012
28
Postprandial proximal gastric acid pocket and gastroesophageal reflux disease. (22171648)
2012
29
The role of obesity in gastroesophageal reflux disease and Barrett's esophagus. (22722430)
2012
30
Gastroesophageal reflux disease: another risk factor for atrial fibrillation? (22261930)
2011
31
Cow's Milk Allergy among Children with Gastroesophageal Reflux Disease. (21927657)
2011
32
Comparison of presentation and impact on quality of life of gastroesophageal reflux disease between young and old adults in a Chinese population. (22147968)
2011
33
Treatment of gastroesophageal reflux disease: a call for increase awareness and local research. (21465947)
2011
34
The value of Carlsson-dent questionnaire in diagnosis of gastroesophageal reflux disease in area with low prevalence of gastroesophageal reflux disease. (21602993)
2011
35
Symptom indexes in refractory gastroesophageal reflux disease: overrated or misunderstood? (21791195)
2011
36
Control of intragastric pH and its relationship to gastroesophageal reflux disease outcomes. (21694609)
2011
37
Prevalence of broncopulmonary and otorhinolaryngologic symptoms in children under investigation for gastroesophageal reflux disease: retrospective analysis. (21739007)
2011
38
Expression pattern of cathepsin W isoforms in peripheral blood and gastroesophageal mucosa of patients with gastroesophageal reflux disease. (22050231)
2011
39
Genetic factors in the pathogenesis of gastroesophageal reflux disease. (21562717)
2011
40
Questionnaire based gastroesophageal reflux disease (GERD) assessment scales. (21785994)
2011
41
Do eosinophil numbers differentiate eosinophilic esophagitis from gastroesophageal reflux disease? (20524860)
2010
42
Menkes disease with gastroesophageal reflux disease and successful surgical treatment: a case report and literature review. (20718197)
2010
43
Prevalence of bile reflux in gastroesophageal reflux disease patients not responsive to proton pump inhibitors. (19140233)
2009
44
Comorbidities in severe asthma: frequency of rhinitis, nasal polyposis, gastroesophageal reflux disease, vocal cord dysfunction and bronchiectasis. (19690661)
2009
45
Gastric ulcer after laparoscopic fundoplication for gastroesophageal reflux disease: significance of the eradication of Helicobacter pylori. (17581465)
2007
46
Gastroesophageal Reflux Disease (GERD) (21919262)
2005
47
Gastroesophageal reflux disease, tooth erosion, and prosthodontic rehabilitation: a clinical report. (15061234)
2003
48
Effect of cytochrome P4502C19 genotypic differences on cure rates for gastroesophageal reflux disease by lansoprazole. (12386647)
2002
49
Head and neck manifestations of gastroesophageal reflux disease. (10498113)
1999
50
Complications of gastroesophageal reflux disease. Role of the lower esophageal sphincter, esophageal acid and acid/alkaline exposure, and duodenogastric reflux. (1632700)
1992

Variations for Gastroesophageal Reflux Disease

About this section

Expression for genes affiliated with Gastroesophageal Reflux Disease

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Gastroesophageal Reflux Disease

Search GEO for disease gene expression data for Gastroesophageal Reflux Disease.

Pathways for genes affiliated with Gastroesophageal Reflux Disease

About this section
Sources:
51PathCards, 56Reactome, 39NCBI BioSystems Database, 31KEGG
See all sources

Compounds for genes affiliated with Gastroesophageal Reflux Disease

About this section
Sources:
46Novoseek, 30IUPHAR, 12DrugBank, 3BitterDB, 25HMDB, 52PharmGKB, 62Tocris Bioscience
See all sources

Compounds related to Gastroesophageal Reflux Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 120)
idCompoundScoreTop Affiliating Genes
1enterogastrone469.8PYY, CCK
2asperlicin469.7CCKAR, CCK
3epft469.6SCT, CCK
41,4-benzodiazepine469.6CCKAR, CCK
5dexloxiglumide46 3010.6CCKAR, CCK
6ym022469.5CCK, CCKAR
7cisapride46 30 1211.5HRH2, CCK, CYP2C19
8lorglumide46 3010.5CCK, CCKAR
9benzodiazepines469.5CCK, HRH2, CCKAR
10l365260469.4CCKAR, CCK
11intralipid469.4PYY, CCK, CCKAR
12pepsinogen469.4CCK, HRH2, SCT
13cimetidine46 30 1211.3CYP2C19, SCT, HRH2
14caerulein469.2CCKAR, CCK, SCT
15diphenhydramine46 30 3 25 1213.2CYP2C19, NTS, HRH2
16acetaminophen46 3 52 25 1213.1PYY, CYP2C19, CCK, HRH2
17amphetamine46 52 1211.0CCK, NTS, PYY
18benzodiazepine469.0CCKAR, CCK, NTS
19ranitidine46 30 25 1211.9HRH2, CCK, SCT, CYP2C19
20clonidine46 52 30 1211.9SCT, NTS, PYY
215-hydroxytryptamine468.7PYY, HRH2, NTS, CCK
22propranolol46 30 52 25 1212.7SCT, PYY, CYP2C19
23opiate468.7CCK, NTS, HRH2
24haloperidol46 52 30 3 1212.7NTS, PYY, CCKAR, CYP2C19
25amine468.6NTS, SCT, PYY, HRH2
26isoproterenol46 129.6PYY, SCT, HRH2, NTS
27cocaine46 129.6NTS, PYY, CCKAR, CCK
28bicarbonate468.6HRH2, SCT, CCK, NTS
29oxyntomodulin46 629.5SCT, NTS, CCK, PYY
30c-peptide468.5NTS, SCT, CCK, PYY
31oleic acid46 30 25 1211.5NTS, PYY, CCKAR, SCT
32carbachol46 30 1210.5NTS, SCT, CCK, PYY
33guanine46 25 1210.5NTS, CCKAR, HRH2, SCT
34loxiglumide468.4CCKAR, NTS, CCK, SCT
35acth468.4PYY, NTS, CCK, SCT
36indomethacin46 30 62 1211.4CYP2C19, CCKAR, SCT, NTS
37norepinephrine46 25 1210.3NTS, CCK, SCT, PYY
38ethanol46 52 25 1211.2SCT, NTS, HRH2, PYY, CYP2C19
39histamine46 30 2510.1NTS, HRH2, PYY, SCT, CCK
40acetylcholine46 52 30 25 1212.1PYY, SCT, CCK, NTS, HRH2
41cyclic amp46 259.1PYY, SCT, CCKAR, NTS, HRH2
42omeprazole46 52 30 25 1212.0HRH2, SCT, CYP2C19, PYY, CCKAR, CCK
43octreotide46 62 30 1211.0CCKAR, PYY, CCK, SCT, NTS
44gaba468.0NTS, PYY, SCT, CCK, CCKAR
45atropine46 30 129.7HRH2, NTS, CCKAR, CCK, SCT, PYY
46tetrodotoxin46 62 309.7NTS, HRH2, CCKAR, CCK, SCT, PYY
47lipid467.6NTS, SCT, HRH2, CCKAR, CYP2C19, PYY
48glucose467.6NTS, CCK, SCT, PYY, CCKAR
49dopamine46 30 25 1210.6SCT, PYY, CYP2C19, NTS, CCK, CCKAR
50tyrosine467.4CYP2C19, CCKAR, PYY, SCT, NTS, CCK

GO Terms for genes affiliated with Gastroesophageal Reflux Disease

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Gastroesophageal Reflux Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.1NTS, CCK, SCT, PYY

Biological processes related to Gastroesophageal Reflux Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1eating behaviorGO:0427559.7CCK, PYY
2feeding behaviorGO:0076319.6CCKAR, PYY
3visual learningGO:0085429.5HRH2, SCT
4digestionGO:0075869.4PYY, CCKAR
5neuron migrationGO:0017649.4CCKAR, CCK
6axonogenesisGO:0074099.1CCKAR, CCK

Molecular functions related to Gastroesophageal Reflux Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051798.9CCK, SCT, PYY
2neuropeptide hormone activityGO:0051848.4NTS, CCK, PYY

Products for genes affiliated with Gastroesophageal Reflux Disease

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gastroesophageal Reflux Disease

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet