GERD
MCID: GST034
MIFTS: 65

Gastroesophageal Reflux Disease (GERD) malady

Gastrointestinal category

Summaries for Gastroesophageal Reflux Disease

Sources:
34MedlinePlus, 64Wikipedia, 47OMIM, 33MalaCards
See all sources

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MedlinePlus:34 Your esophagus is the tube that carries food from your mouth to your stomach. gastroesophageal reflux disease (gerd) happens when a muscle at the end of your esophagus does not close properly. this allows stomach contents to leak back, or reflux, into the esophagus and irritate it. you may feel a burning in the chest or throat called heartburn. sometimes, you can taste stomach fluid in the back of the mouth. if you have these symptoms more than twice a week, you may have gerd. you can also have gerd without having heartburn. your symptoms could include a dry cough, asthma symptoms, or trouble swallowing. anyone, including infants and children, can have gerd. if not treated, it can lead to more serious health problems. in some cases, you might need medicines or surgery. however, many people can improve their symptoms by avoiding alcohol and spicy, fatty or acidic foods that trigger heartburn eating smaller meals not eating close to bedtime losing weight if needed wearing loose-fitting clothes nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Gastroesophageal Reflux Disease, also known as gastroesophageal reflux, is related to dyspepsia and barrett's esophagus. An important gene associated with Gastroesophageal Reflux Disease is GER (Gastroesophageal reflux), and among its related pathways are Citalopram Pathway, Pharmacokinetics and Ifosfamide Pathway, Pharmacokinetics. The drugs aluminum hydroxide and aluminum hydroxide gel and the compounds pge2 and ranitidine have been mentioned in the context of this disorder. Affiliated tissues include liver, tongue and kidney, and related mouse phenotypes are endocrine/exocrine gland and homeostasis/metabolism.

Wikipedia:64 Gastroesophageal reflux disease (GERD), gastro-oesophageal reflux disease (GORD), gastric reflux... more...

Description from OMIM:47 109350

Aliases & Classifications for Gastroesophageal Reflux Disease

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 34MedlinePlus, 9diseasecard, 47OMIM, 57SNOMED-CT, 35MeSH, 40NCIt, 27ICD9CM
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal


Aliases & Descriptions:

gastroesophageal reflux disease 8 10 45 61
gastroesophageal reflux 8 9 47
gerd 8 34
gerd - gastro-esophageal reflux disease 8
gastro-esophageal reflux 8
gastresophageal reflux 8
acid reflux 8


External Ids:

Disease Ontology8 DOID:8534
MeSH35 D005764
OMIM47 109350
NCIt40 C26781
ICD9CM27 530.81

Related Diseases for Gastroesophageal Reflux Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Gastroesophageal Reflux Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 292)
idRelated DiseaseScoreTop Affiliating Genes
1dyspepsia31.0MLN, GAST, CCK, HRH2
2barrett's esophagus31.0S100A8, PTGS1, GAST
3adenocarcinoma31.0PTGS1, PYY, CSN1S1, SCT, CCK, GAST
4asthma30.9S100A8, HRH2, CSN1S1, SCT, NTS, PTGS1
5bile reflux30.9CCK
6irritable bowel syndrome30.8MLN, TRPV1, CCK
7morbid obesity30.8GCG, CCK, PYY
8gastric ulcer30.6CYP2C19, S100A8, HRH2, GAST, PTGS1, TRPV1
9duodenal ulcer30.4S100A8, SCT, HRH2, GAST
10autonomic neuropathy30.4GAST, MLN, GCG, CCK
11arthritis30.4CSN1S1, HRH2, S100A8, PTGS1, TRPV1
12parkinson's disease30.2NTS
13zollinger-ellison syndrome30.2HRH2, GAST, SCT
14duodenogastric reflux30.2GAST, MLN, CCK, NTS
15cystic fibrosis30.2S100A8, SCT, NTS, DNAH8
16gastroparesis30.2GCG, CCK, MLN, GAST
17bulimia nervosa30.2CCK, PYY
18celiac disease30.2PYY, CSN1S1, CCK
19dumping syndrome30.1NTS, PYY, MLN, GCG
20atrophic gastritis29.9SCT, GAST, S100A8
21stomach disease29.9PTGS1, HRH2
22cholelithiasis29.9CCK
23eosinophilic esophagitis10.7
24h. pylori infection10.5
25tooth disease10.5
26devic disease10.5
27barrett esophagus/esophageal adenocarcinoma10.5
28barrett's adenocarcinoma10.5
29tooth erosion10.5
30sleep apnea10.5
31bruxism10.4
32m�ni�re disease10.4
33pulmonary function10.4
34pulmonary disease, chronic obstructive10.4
35hereditary sensory and autonomic neuropathy type 1b10.3
36bronchiolitis obliterans10.3
37bronchiolitis10.3
38achalasia10.3
39tongue disease10.3
40chronic hiccups10.3
41swallowing disorders10.3
42ehlers–danlos syndrome10.2
43type i ehlers-danlos syndrome10.2
44intrinsic asthma10.2
45systemic scleroderma10.2
46pierre robin sequence10.2
47abdominal wall defect10.2
48diabetic nephropathy10.2
49major depressive disorder10.2
50menkes disease10.2

Graphical network of the top 20 diseases related to Gastroesophageal Reflux Disease:



Diseases related to gastroesophageal reflux disease

Clinical Features for Gastroesophageal Reflux Disease

Sources:
47OMIM
See all sources

Clinical features from OMIM:

109350

Drugs & Therapeutics for Gastroesophageal Reflux Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Genetic Tests for Gastroesophageal Reflux Disease

Anatomical Context for Gastroesophageal Reflux Disease

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Gastroesophageal Reflux Disease:

33
Liver, Tongue, Kidney, Lung, Bone marrow, Heart, Colon, T cells, B cells, Bronchial epithelium

Animal Models for Gastroesophageal Reflux Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Gastroesophageal Reflux Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.1CCKAR, CCK, GAST, MAB21L1, PTGS1, GCG
2MP:00053769.7PTGS1, GCG, PYY, CCKAR, CCK, SCT

Publications for Gastroesophageal Reflux Disease

Sources:
51PubMed
See all sources

Articles related to Gastroesophageal Reflux Disease:

(show top 50)    (show all 608)
idTitleAuthorsYear
1
The diagnostic value of gastroesophageal reflux disease (GERD) symptoms and detection of pepsin and bile acids in bronchoalveolar lavage fluid and exhaled breath condensate for identifying lung transplantation patients with GERD-induced aspiration. (24414458)
2014
2
Association of sleep dysfunction and emotional status with gastroesophageal reflux disease in Korea. (23875102)
2013
3
Laparoscopic anterior 180-degree versus nissen fundoplication for gastroesophageal reflux disease: systematic review and meta-analysis of randomized clinical trials. (23470572)
2013
4
High-resolution Manometry and Globus: Comparison of Globus, Gastroesophageal Reflux Disease and Normal Controls Using High-resolution Manometry. (24199007)
2013
5
Lifestyle characteristics and gastroesophageal reflux disease: a population-based study in Albania. (23509449)
2013
6
Pathophysiology of gastroesophageal reflux disease. (23998973)
2013
7
Gastroesophageal reflux disease prevalence in the city of Sivas. (24254260)
2013
8
Barrett's esophagus in Latinos undergoing endoscopy for gastroesophageal reflux disease symptoms. (22332868)
2013
9
A case of obstructive sleep apnea, gastroesophageal reflux disease, and chronic hiccups: will CPAP help? (23319912)
2013
10
Gastroesophageal Reflux Disease Questionnaire (GerdQ) in real-world practice: a national multicenter survey on 8065 patients. (23301662)
2013
11
Increased Proximal Reflux in a Hypersensitive Esophagus Might Explain Symptoms Resistant to Proton Pump Inhibitors in Patients With Gastroesophageal Reflux Disease. (24184737)
2013
12
Online follow-up of individuals with gastroesophageal reflux disease using a patient-reported outcomes instrument: results of an observational study. (24083342)
2013
13
Gastroesophageal reflux disease and sleep. (23452631)
2013
14
Structured diagnostic and treatment approach versus the usual primary care approach in patients with gastroesophageal reflux disease: a cluster-randomized multicenter study. (23426452)
2013
15
Comparative Study of 2 Different Questionnaires in Japanese Patients: The Quality of Life and Utility Evaluation Survey Technology Questionnaire (QUEST) Versus the Frequency Scale for the Symptoms of Gastroesophageal Reflux Disease Questionnaire (FSSG). (23350048)
2013
16
Correlation of the gastroesophageal flap valve grade with the surgery rate in patients with gastroesophageal reflux disease. (23052497)
2013
17
Response of chronic cough to acid-suppressive therapy in patients with gastroesophageal reflux disease. (23117307)
2013
18
Gastroesophageal reflux disease and antireflux surgery-what is the proper preoperative work-up? (23090280)
2013
19
Gastroesophageal Reflux Disease Relief in Patients Treated with Rabeprazole 20a88mg versus Omeprazole 20a88mg: A Meta-Analysis. (24106498)
2013
20
Prognostic values of multichannel intraluminal impedance and pH monitoring in newborns with symptoms of gastroesophageal reflux disease. (23146428)
2013
21
The role of obesity in gastroesophageal reflux disease and Barrett's esophagus. (22722430)
2012
22
Utility of pH/multichannel intraluminal impedance probe in identifying operative patients in infants with gastroesophageal reflux disease. (22568542)
2012
23
Air column in esophagus and symptoms of gastroesophageal reflux disease. (22277022)
2012
24
Effect of Helicobacter pylori treatment on gastroesophageal reflux disease (GERD): meta-analysis of randomized controlled trials. (22229305)
2012
25
The Therapeutic and Diagnostic Value of 2-week High Dose Proton Pump Inhibitor Treatment in Overlapping Non-erosive Gastroesophageal Reflux Disease and Functional Dyspepsia Patients. (22523726)
2012
26
Open access capture of patients with gastroesophageal reflux disease using an online patient-reported outcomes instrument. (23611985)
2012
27
Low levels of adherence with proton pump inhibitor therapy contribute to therapeutic failure in gastroesophageal reflux disease. (21777341)
2012
28
In gastroesophageal reflux disease, differential gene expression in the duodenum points towards enhanced chylomicron production and secretion. (22350785)
2012
29
Salivary parameters and teeth erosions in patients with gastroesophageal reflux disease. (23011245)
2012
30
Prevalence and demographic determinants of gastroesophageal reflux disease (GERD) in the Turkish general population: a population-based cross-sectional study. (22965502)
2012
31
Limited ability of the proton-pump inhibitor test to identify patients with gastroesophageal reflux disease. (22813439)
2012
32
Nonerosive gastroesophageal reflux disease and mild degree of esophagitis: comparison of symptoms endoscopic, manometric and pH-metric patterns. (22591510)
2012
33
Extraesophageal gastroesophageal reflux disease (GERD) symptoms are not more frequently associated with proximal esophageal reflux than typical GERD symptoms. (22243631)
2012
34
Gastroesophageal reflux disease: another risk factor for atrial fibrillation? (22261930)
2011
35
Pharmacokinetics and tolerability of rabeprazole in children 1 to 11 years old with gastroesophageal reflux disease. (21478756)
2011
36
Columnar-lined esophagus CK7 positive is an early marker of gastroesophageal reflux disease. (21502913)
2011
37
Curry induces acid reflux and symptoms in gastroesophageal reflux disease. (21735083)
2011
38
SSAT maintenance of certification: literature review on gastroesophageal reflux disease and hiatal hernia. (21594701)
2011
39
Gastroesophageal reflux disease: endoscopy, duration of treatment, and choice of PPI. (21667598)
2011
40
P53 and Ki-67 overexpression in gastroesophageal reflux disease--Barrett's esophagus and adenocarcinoma sequence. (19302208)
2009
41
Gastroesophageal reflux disease correlation with posterior laryngitis. (19489474)
2009
42
Prevalence and risk factors for overlaps between gastroesophageal reflux disease, dyspepsia, and irritable bowel syndrome: a population-based study. (19342860)
2009
43
Gastroesophageal reflux disease: alexithymia and attachment style. (17918582)
2007
44
Influence of CYP2C19 polymorphism and Helicobacter pylori status on the antisecretory effect of omeprazole in gastroesophageal reflux disease]. (17047431)
2006
45
Gastroesophageal Reflux Disease (GERD) (21919262)
2005
46
Esomeprazole-induced healing of gastroesophageal reflux disease is unrelated to the genotype of CYP2C19: evidence from clinical and pharmacokinetic data. (16338278)
2005
47
Effects of gastroesophageal reflux disease in laryngeal carcinoma. (15373871)
2004
48
Gastroesophageal reflux disease and progressive nephropathy after improving glycemic control in an adolescent with diabetic dwarfism. (11815520)
2002
49
The importance of vacA, cagA, and iceA genotypes of Helicobacter pylori infection in peptic ulcer disease and gastroesophageal reflux disease. (11569682)
2001
50
Chronic hiccups and gastroesophageal reflux disease: the acid perfusion test as a provocative maneuver. (3729205)
1986

Genetic Variations for Gastroesophageal Reflux Disease

Expression for genes affiliated with Gastroesophageal Reflux Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Gastroesophageal Reflux Disease

Search GEO for disease gene expression data for Gastroesophageal Reflux Disease.

Pathways for genes affiliated with Gastroesophageal Reflux Disease

Sources:
50PharmGKB, 54Reactome, 38NCBI BioSystems Database, 30KEGG
See all sources

Pathways related to Gastroesophageal Reflux Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4CYP2C19, CYP3A4
2
Hide members
10.4CYP3A4, CYP2C19
3
Hide members
10.4CYP2C19, CYP3A4
410.4CYP3A4, PTGS1
5
Hide members
10.3CYP2C19, CYP3A4, PTGS1
6
Hide members
10.1GCG, CCKAR, CCK, GAST, MLN, NTS
7
Hide members
10.0CCKAR, GCG, PYY, CCK, SCT, MLN
8
Hide members
10.0PYY, HRH2, SCT, NTS, GCG, MLN

Compounds for genes affiliated with Gastroesophageal Reflux Disease

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 2BitterDB, 50PharmGKB, 60Tocris Bioscience
See all sources

Compounds related to Gastroesophageal Reflux Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 307)
idCompoundScoreTop Affiliating Genes
1pge24510.7TRPV1
2ranitidine45 29 11 2413.7HRH2, CYP2C19, MLN, SCT, CCK
3acetaminophen45 2 50 11 2414.7PYY, CSN1S1, CYP2C19, CYP3A4, HRH2
4loxiglumide4510.6SCT, CCKAR, GAST, CCK, NTS
5caerulein4510.6CCKAR, MLN, SCT, CCK
6lafutidine4510.6HRH2, GAST, SCT, MLN
7diphenhydramine45 29 2 11 2414.6PTGS1, HRH2, CYP3A4, CYP2C19, NTS
8amoxicillin45 50 1112.6DSPP, S100A8, GAST, CYP2C19, HRH2
9pepsinogen4510.6HRH2, GAST, SCT, CCK
10pantoprazole45 50 11 2413.6GAST, DNAH8, CYP2C19, CYP3A4, HRH2
11metronidazole45 1111.6GAST, CYP3A4, S100A8, CYP2C19, DSPP
12lansoprazole50 45 11 2413.6GAST, DNAH8, CYP2C19, CYP3A4, HRH2
13clarithromycin45 1111.6CYP3A4, S100A8, GAST, CYP2C19, HRH2
14peptone4510.6GCG, GAST, CSN1S1, CCK
15cisapride45 29 1112.6HRH2, GCG, CCK, MLN, CYP2C19, CYP3A4
16ondansetron45 50 11 2413.6MLN, GAST, CCK, CCKAR, CYP3A4
17bethanechol45 29 1112.6GCG, CCK, GAST, MLN
18c-peptide4510.5CCK, GAST, NTS, GCG, PYY, SCT
19oxyntomodulin45 6011.5NTS, MLN, GAST, SCT, CCK, GCG
20octreotide45 60 29 1113.5NTS, GCG, MLN, GAST, SCT, CCK
21morphine45 50 29 1113.5CCKAR, CSN1S1, NTS, TRPV1, CYP3A4, CCK
22tetrodotoxin45 60 2912.5GCG, CCK, SCT, MLN, NTS, TRPV1
23gaba4510.5TRPV1, CCKAR, NTS, GAST, SCT, CCK
24atropine45 29 1112.5GAST, MLN, NTS, HRH2, SCT, CCK
25cimetidine45 29 1112.5GAST, HRH2, CYP3A4, CYP2C19, SCT
265-hydroxytryptamine4510.5CCK, GAST, HRH2, MLN, PYY, NTS
27cocaine45 1111.4CCK, CCKAR, PYY, GCG, CYP3A4, NTS
28epinephrine45 11 2412.4HRH2, GCG, GAST, NTS, DSPP, DNAH8
29clonidine45 29 1112.4DNAH8, CYP3A4, NTS, PYY, SCT
30nifedipine45 50 29 1113.4GAST, MLN, GCG, NTS, CYP2C19, CYP3A4
31diclofenac45 29 50 1113.4CYP2C19, CYP3A4, HRH2, PTGS1, CSN1S1
32indomethacin45 60 29 1113.4PTGS1, CYP2C19, DNAH8, NTS, SCT, CCKAR
33carbachol45 29 1112.4NTS, GAST, CCK, PYY, GCG, SCT
34dopamine45 29 11 2413.4GAST, TRPV1, MLN, SCT, CCK, CCKAR
35histamine45 29 2412.4CCK, HRH2, NTS, SCT, CSN1S1, PYY
36hydrogen45 2411.4SCT, CYP2C19, DNAH8, TRPV1, MLN, GAST
37acetylcholine45 50 29 11 2414.3CCK, HRH2, GAST, SCT, MLN, CSN1S1
38adenylate4510.3TRPV1, MLN, GAST, GCG, DNAH8, NTS
39omeprazole45 29 50 11 2414.3HRH2, CYP3A4, CYP2C19, DNAH8, MLN, GAST
40erythromycin45 50 2 1113.3CCKAR, CYP3A4, MLN, CYP2C19, GAST
41carbohydrates4510.3CSN1S1, CCK, CCKAR, PYY, DSPP, GCG
42serine4510.3CSN1S1, S100A8, PYY, GCG, MLN, NTS
43glutamate4510.2SCT, PTGS1, DNAH8, TRPV1, CSN1S1, GCG
44alanine4510.2PTGS1, CSN1S1, S100A8, CCKAR, GCG, DNAH8
45ethanol45 50 11 2413.1SCT, PYY, NTS, TRPV1, CYP2C19, CYP3A4
46norepinephrine45 11 2412.1DNAH8, GCG, PYY, CCK, SCT, GAST
47calcium45 50 11 2413.1S100A8, CCK, CCKAR, PYY, SCT, CSN1S1
48arginine4510.0DNAH8, DSPP, NTS, MLN, SCT, CCK
49thyroxine45 2411.0CSN1S1, DNAH8, NTS, GAST, MLN, SCT
50domperidone45 29 1112.0HRH2, CYP3A4, GAST, MLN

GO Terms for genes affiliated with Gastroesophageal Reflux Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Gastroesophageal Reflux Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.0NTS, MLN, GAST, SCT, CSN1S1, S100A8

Biological processes related to Gastroesophageal Reflux Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1feeding behaviorGO:00763110.4CCKAR, PYY, GCG
2heterocycle metabolic processGO:04648310.4CYP2C19, CYP3A4
3monoterpenoid metabolic processGO:01609810.3CYP2C19, CYP3A4
4G-protein coupled receptor signaling pathwayGO:00718610.2MLN, GAST, PYY, GCG
5exogenous drug catabolic processGO:04273810.1CYP3A4, CYP2C19

Molecular functions related to Gastroesophageal Reflux Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid hydroxylase activityGO:00839510.4CYP3A4, CYP2C19
2hormone activityGO:00517910.0MLN, GCG, PYY, CCK, SCT, GAST
3neuropeptide hormone activityGO:00518410.0NTS, CCK, PYY

Products for genes affiliated with Gastroesophageal Reflux Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gastroesophageal Reflux Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet