GERD
MCID: GST034
MIFTS: 67

Gastroesophageal Reflux Disease (GERD) malady

Gastrointestinal diseases category

Summaries for Gastroesophageal Reflux Disease

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33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Your esophagus is the tube that carries food from your mouth to your stomach. gastroesophageal reflux disease (gerd) happens when a muscle at the end of your esophagus does not close properly. this allows stomach contents to leak back, or reflux, into the esophagus and irritate it. you may feel a burning in the chest or throat called heartburn. sometimes, you can taste stomach fluid in the back of the mouth. if you have these symptoms more than twice a week, you may have gerd. you can also have gerd without having heartburn. your symptoms could include a dry cough, asthma symptoms, or trouble swallowing. anyone, including infants and children, can have gerd. if not treated, it can lead to more serious health problems. in some cases, you might need medicines or surgery. however, many people can improve their symptoms by avoiding alcohol and spicy, fatty or acidic foods that trigger heartburn eating smaller meals not eating close to bedtime losing weight if needed wearing loose-fitting clothes nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Gastroesophageal Reflux Disease, also known as gastroesophageal reflux, is related to esophagitis and obesity. An important gene associated with Gastroesophageal Reflux Disease is GER (Gastroesophageal reflux), and among its related pathways are Citalopram Pathway, Pharmacokinetics and Ifosfamide Pathway, Pharmacokinetics. The drugs aluminum hydroxide and aluminum hydroxide gel and the compounds pge2 and ranitidine have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and lung, and related mouse phenotypes are endocrine/exocrine gland and homeostasis/metabolism.

Wikipedia:63 Gastroesophageal reflux disease (GERD), gastro-oesophageal reflux disease (GORD), gastric reflux... more...

Description from OMIM:46 109350

Aliases & Classifications for Gastroesophageal Reflux Disease

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Sources:
8Disease Ontology, 9diseasecard, 46OMIM, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

gastroesophageal reflux disease 8 10 44 60
gastroesophageal reflux 8 9 46
gerd 8 33
gerd - gastro-esophageal reflux disease 8
gastro-esophageal reflux 8
gastresophageal reflux 8
acid reflux 8


External Ids:

Disease Ontology8 DOID:8534
MeSH34 D005764
OMIM46 109350
NCIt39 C26781
ICD9CM27 530.81

Related Diseases for Gastroesophageal Reflux Disease

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17GeneCards, 18GeneDecks
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Diseases related to Gastroesophageal Reflux Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 299)
idRelated DiseaseScoreTop Affiliating Genes
1esophagitis31.6S100A8, GAST, NTS, TRPV1, CYP2C19, HRH2
2obesity31.2NTS, PYY, CYP3A4, CCKAR, TRPV1, CSN1S1
3barrett's esophagus31.1S100A8, PTGS1, GAST
4dyspepsia31.0MLN, GAST, CCK, HRH2
5adenocarcinoma30.9PTGS1, PYY, CSN1S1, SCT, CCK, GAST
6asthma30.9S100A8, HRH2, CSN1S1, SCT, NTS, PTGS1
7bile reflux30.8CCK
8irritable bowel syndrome30.8MLN, TRPV1, CCK
9morbid obesity30.7GCG, CCK, PYY
10diabetes mellitus30.6CCKAR, CSN1S1, CCK, MLN, SCT, CYP3A4
11duodenitis30.5GAST, S100A8
12neuropathy30.5DNAH8, TRPV1
13gastric ulcer30.5CYP2C19, S100A8, HRH2, GAST, PTGS1, TRPV1
14peptic ulcer30.5PTGS1, HRH2, CYP2C19, DNAH8, GAST, SCT
15duodenal ulcer30.4S100A8, SCT, HRH2, GAST
16autonomic neuropathy30.4GAST, MLN, GCG, CCK
17arthritis30.4CSN1S1, HRH2, S100A8, PTGS1, TRPV1
18rheumatoid arthritis30.4TRPV1, CSN1S1, PTGS1, DNAH8, CYP3A4, DSPP
19parkinson's disease30.2NTS
20zollinger-ellison syndrome30.2HRH2, GAST, SCT
21hepatitis30.2HRH2, CYP3A4
22duodenogastric reflux30.2GAST, MLN, CCK, NTS
23cystic fibrosis30.2S100A8, SCT, NTS, DNAH8
24gastritis30.2GAST, SCT, S100A8
25gastroparesis30.2GCG, CCK, MLN, GAST
26bulimia nervosa30.2CCK, PYY
27celiac disease30.2PYY, CSN1S1, CCK
28type 2 diabetes mellitus30.2PYY, CCKAR, CCK, CSN1S1, SCT, GCG
29constipation30.0PYY, MLN, CCK
30dumping syndrome30.0NTS, PYY, MLN, GCG
31atrophic gastritis29.9SCT, GAST, S100A8
32stomach disease29.8PTGS1, HRH2
33cholelithiasis29.8CCK
34gastric adenocarcinoma29.8HRH2, GAST, S100A8
35esophageal disease11.1
36eosinophilic esophagitis10.7
37laryngeal disease10.6
38laryngitis10.6
39esophagus adenocarcinoma10.5
40hiatus hernia10.5
41barrett's adenocarcinoma10.5
42tooth disease10.5
43tooth erosion10.4
44bruxism10.4
45diabetic neuropathy10.4
46duodenal disease10.4
47movement disease10.4
48hereditary sensory and autonomic neuropathy type 1b10.3
49bronchiolitis obliterans10.3
50bronchiolitis10.3

Graphical network of the top 20 diseases related to Gastroesophageal Reflux Disease:



Diseases related to gastroesophageal reflux disease

Clinical Features for Gastroesophageal Reflux Disease

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Sources:
46OMIM
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Clinical features from OMIM:

109350

Drugs & Therapeutics for Gastroesophageal Reflux Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Gastroesophageal Reflux Disease

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Anatomical Context for Gastroesophageal Reflux Disease

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Sources:
32MalaCards
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MalaCards organs/tissues related to Gastroesophageal Reflux Disease:

32
Kidney, Testes, Lung, Liver, T cells, Bone marrow, Colon, Heart, Bone, Tongue

Animal Models for Gastroesophageal Reflux Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Gastroesophageal Reflux Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.1CCKAR, CCK, GAST, MAB21L1, PTGS1, GCG
2MP:00053769.7PTGS1, GCG, PYY, CCKAR, CCK, SCT

Publications for Gastroesophageal Reflux Disease

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Sources:
50PubMed
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Articles related to Gastroesophageal Reflux Disease:

(show top 50)    (show all 607)
idTitleAuthorsYear
1
Incidence of gastroesophageal reflux disease and positive maxillary antral cultures in children with symptoms of chronic rhinosinusitis. (24360949)
2014
2
Cardiac mucosa at the Gastroesophageal Junction: Indicator of Gastroesophageal Reflux Disease? Data from a Prospective Central European Multicenter Study on histologic and endoscopic diagnosis of esophagitis (histoGERD). (24393213)
2014
3
Gastroesophageal reflux disease. (23853605)
2013
4
Generation of Gastroesophageal Reflux Disease Symptoms During Esophageal Acid Infusion With Concomitant Esophageal pH Monitoring in Healthy Adults. (24199011)
2013
5
Endolumenal therapies for gastroesophageal reflux disease. (23168118)
2013
6
Are there risks associated with empiric acid suppression treatment of infants and children suspected of having gastroesophageal reflux disease? (24319831)
2013
7
Development of food allergies in patients with gastroesophageal reflux disease treated with gastric acid suppressive medications. (23905907)
2013
8
What is the best test for pediatric gastroesophageal reflux disease? (24114940)
2013
9
Esophageal barrier function and tight junction expression in healthy subjects and patients with gastroesophageal reflux disease: functionality of esophageal mucosa exposed to bile salt and trypsin in vitro. (24047393)
2013
10
Atrial fibrillation ablation in patients with gastroesophageal reflux disease or irritable bowel syndrome-the heart to gut connection! (23736874)
2013
11
Combined multichannel intraluminal impedance and pH monitoring assists the diagnosis of sliding hiatal hernia in children with gastroesophageal reflux disease. (23397115)
2013
12
Guidelines for the diagnosis and management of gastroesophageal reflux disease. (23419381)
2013
13
Gastroesophageal reflux disease: impact on work productivity and daily-life activities of daytime workers. A French cross-sectional study. (23238032)
2013
14
Diagnostic accuracy of tests in pediatric gastroesophageal reflux disease. (23219449)
2013
15
Diagnosis and management of gastroesophageal reflux disease (GERD): an Indian perspective. (23396785)
2013
16
Gastroesophageal reflux disease in neonates and infants : when and how to treat. (23322552)
2013
17
Comparison of central and intraesophageal factors between gastroesophageal reflux disease (GERD) patients and those with GERD-related noncardiac chest pain. (22309285)
2012
18
Gastroesophageal reflux disease and tympanoplasty surgical outcome: is there a relationship? (22494440)
2012
19
Symptoms and quality of life in underweight gastroesophageal reflux disease patients and therapeutic responses to proton pump inhibitors. (22142515)
2012
20
The impact of the vitamins A, C and E in the prevention of gastroesophageal reflux disease, Barrett's oesophagus and oesophageal adenocarcinoma. (23213946)
2012
21
Influence of lumbar kyphosis and back muscle strength on the symptoms of gastroesophageal reflux disease in middle-aged and elderly people. (22370926)
2012
22
A single institution's experience and journey with over 1000 laparoscopic fundoplications for gastroesophageal reflux disease. (22964197)
2012
23
Positive effect of abdominal breathing exercise on gastroesophageal reflux disease: a randomized, controlled study. (22146488)
2012
24
Gastroesophageal Reflux Disease in Iran: SEPAHAN Systematic Review No. 2. (22826749)
2012
25
Gastroesophageal reflux disease and postlaryngectomy tracheoesophageal fistula. (22298249)
2012
26
Impaired ghrelin signaling is associated with gastrointestinal dysmotility in rats with gastroesophageal reflux disease. (22517773)
2012
27
Lifestyle factors affecting gastroesophageal reflux disease symptoms: a cross-sectional study of healthy 19864 adults using FSSG scores. (22554226)
2012
28
The effects of laparoscopic Nissen fundoplication on patients with severe gastroesophageal reflux disease and steroid-dependent asthma. (22703777)
2012
29
Prevalence of broncopulmonary and otorhinolaryngologic symptoms in children under investigation for gastroesophageal reflux disease: retrospective analysis. (21739007)
2011
30
Review of the persistence of gastroesophageal reflux disease in children, adolescents and adults: does gastroesophageal reflux disease in adults sometimes begin in childhood? (21675820)
2011
31
Gastroesophageal reflux disease. (21889027)
2011
32
Effects of environment and lifestyle on gastroesophageal reflux disease. (21734389)
2011
33
Characteristics of non-erosive gastroesophageal reflux disease refractory to proton pump inhibitor therapy. (21528060)
2011
34
Relationship between atrial fibrillation and gastroesophageal reflux disease: a multicenter questionnaire survey. (21985841)
2011
35
How is the autonomic nerve function different between gastroesophageal reflux disease alone and gastroesophageal reflux disease with diabetes mellitus neuropathy? (22148117)
2011
36
The histological and immunohistochemical aspects of bile reflux in patients with gastroesophageal reflux disease. (21822428)
2011
37
Association between gastroesophageal reflux disease and laparoscopic sleeve gastrectomy. (21429818)
2011
38
Introduction to the Mini-Symposium on new advances in the diagnosis and treatment of gastroesophageal reflux disease. (21349781)
2011
39
Do eosinophil numbers differentiate eosinophilic esophagitis from gastroesophageal reflux disease? (20524860)
2010
40
Gastroesophageal reflux disease and morbid obesity: is there a relation? (19404705)
2009
41
Chronic mucosal inflammation of the gastric cardia in gastroesophageal reflux disease is not regulated by FOXP3-expressing T cells. (19242793)
2009
42
Gastroesophageal reflux disease does not lead to changes in the secretory leukocyte protease inhibitor expression in esophageal mucosa. (19212204)
2009
43
Increased expression of eotaxin-3 distinguishes between eosinophilic esophagitis and gastroesophageal reflux disease. (17900656)
2007
44
Lack of distal esophageal contractions is a key determinant of gastroesophageal reflux disease after repair of esophageal atresia. (18082699)
2007
45
Gastroesophageal Reflux Disease (GERD) Hospitalizations in 1998 and 2005: Statistical Brief #44 (21755625)
2006
46
Gastroesophageal reflux disease, tooth erosion, and prosthodontic rehabilitation: a clinical report. (15061234)
2003
47
Effect of cytochrome P4502C19 genotypic differences on cure rates for gastroesophageal reflux disease by lansoprazole. (12386647)
2002
48
Enhancement of salivary esophagoprotection: rationale for a physiological approach to gastroesophageal reflux disease. (8608875)
1996
49
Association of gastroesophageal reflux with obstructive lung disease in children after allogeneic bone marrow transplantation. (7780159)
1995
50
Gastroesophageal reflux disease is associated with enteric hormone abnormalities. (8311131)
1994

Genetic Variations for Gastroesophageal Reflux Disease

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Expression for genes affiliated with Gastroesophageal Reflux Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gastroesophageal Reflux Disease

Search GEO for disease gene expression data for Gastroesophageal Reflux Disease.

Pathways for genes affiliated with Gastroesophageal Reflux Disease

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Sources:
49PharmGKB, 53Reactome, 37NCBI BioSystems Database, 29KEGG
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Pathways related to Gastroesophageal Reflux Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4CYP2C19, CYP3A4
2
Hide members
10.4CYP2C19, CYP3A4
3
Hide members
10.4CYP2C19, CYP3A4
410.4PTGS1, CYP3A4
5
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10.3CYP2C19, CYP3A4, PTGS1
6
Hide members
10.1GCG, CCKAR, CCK, GAST, MLN, NTS
7
Hide members
10.0HRH2, GCG, PYY, CCKAR, CCK, SCT
8
Hide members
10.0GCG, PYY, CCKAR, CCK, SCT, GAST

Compounds for genes affiliated with Gastroesophageal Reflux Disease

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 2BitterDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Gastroesophageal Reflux Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 307)
idCompoundScoreTop Affiliating Genes
1pge24410.7TRPV1
2ranitidine44 28 11 2413.7HRH2, CYP2C19, MLN, SCT, CCK
3acetaminophen44 2 49 11 2414.7PYY, CSN1S1, CYP2C19, CYP3A4, HRH2
4loxiglumide4410.6SCT, CCKAR, GAST, CCK, NTS
5caerulein4410.6CCKAR, MLN, SCT, CCK
6lafutidine4410.6HRH2, GAST, SCT, MLN
7diphenhydramine44 28 2 11 2414.6PTGS1, HRH2, CYP3A4, CYP2C19, NTS
8amoxicillin44 49 1112.6DSPP, S100A8, GAST, CYP2C19, HRH2
9pepsinogen4410.6HRH2, GAST, SCT, CCK
10pantoprazole44 49 11 2413.6GAST, DNAH8, CYP2C19, CYP3A4, HRH2
11metronidazole44 1111.6GAST, CYP3A4, S100A8, CYP2C19, DSPP
12lansoprazole49 44 11 2413.6GAST, DNAH8, CYP2C19, CYP3A4, HRH2
13clarithromycin44 1111.6CYP3A4, S100A8, GAST, CYP2C19, HRH2
14peptone4410.6GCG, GAST, CSN1S1, CCK
15cisapride44 28 1112.6HRH2, GCG, CCK, MLN, CYP2C19, CYP3A4
16ondansetron44 49 11 2413.6MLN, GAST, CCK, CCKAR, CYP3A4
17bethanechol44 28 1112.6GCG, CCK, GAST, MLN
18c-peptide4410.5CCK, GAST, NTS, GCG, PYY, SCT
19oxyntomodulin44 5911.5NTS, MLN, GAST, SCT, CCK, GCG
20octreotide44 59 28 1113.5NTS, GCG, MLN, GAST, SCT, CCK
21morphine44 49 28 1113.5CCKAR, CSN1S1, NTS, TRPV1, CYP3A4, CCK
22tetrodotoxin44 59 2812.5GCG, CCK, SCT, MLN, NTS, TRPV1
23gaba4410.5TRPV1, CCKAR, NTS, GAST, SCT, CCK
24atropine44 28 1112.5GAST, MLN, NTS, HRH2, SCT, CCK
25cimetidine44 28 1112.5GAST, HRH2, CYP3A4, CYP2C19, SCT
265-hydroxytryptamine4410.5CCK, GAST, HRH2, MLN, PYY, NTS
27cocaine44 1111.4CCK, CCKAR, PYY, GCG, CYP3A4, NTS
28epinephrine44 11 2412.4HRH2, GCG, GAST, NTS, DSPP, DNAH8
29clonidine44 28 1112.4DNAH8, CYP3A4, NTS, PYY, SCT
30nifedipine44 49 28 1113.4GAST, MLN, GCG, NTS, CYP2C19, CYP3A4
31diclofenac44 28 49 1113.4CYP2C19, CYP3A4, HRH2, PTGS1, CSN1S1
32indomethacin44 59 28 1113.4PTGS1, CYP2C19, DNAH8, NTS, SCT, CCKAR
33carbachol44 28 1112.4NTS, GAST, CCK, PYY, GCG, SCT
34dopamine44 28 11 2413.4GAST, TRPV1, MLN, SCT, CCK, CCKAR
35histamine44 28 2412.4CCK, HRH2, NTS, SCT, CSN1S1, PYY
36hydrogen44 2411.4SCT, CYP2C19, DNAH8, TRPV1, MLN, GAST
37acetylcholine44 49 28 11 2414.3CCK, HRH2, GAST, SCT, MLN, CSN1S1
38adenylate4410.3TRPV1, MLN, GAST, GCG, DNAH8, NTS
39omeprazole44 28 49 11 2414.3HRH2, CYP3A4, CYP2C19, DNAH8, MLN, GAST
40erythromycin44 49 2 1113.3CCKAR, CYP3A4, MLN, CYP2C19, GAST
41carbohydrates4410.3CSN1S1, CCK, CCKAR, PYY, DSPP, GCG
42serine4410.3CSN1S1, S100A8, PYY, GCG, MLN, NTS
43glutamate4410.2SCT, PTGS1, DNAH8, TRPV1, CSN1S1, GCG
44alanine4410.2PTGS1, CSN1S1, S100A8, CCKAR, GCG, DNAH8
45ethanol44 49 11 2413.1SCT, PYY, NTS, TRPV1, CYP2C19, CYP3A4
46norepinephrine44 11 2412.1DNAH8, GCG, PYY, CCK, SCT, GAST
47calcium44 49 11 2413.1S100A8, CCK, CCKAR, PYY, SCT, CSN1S1
48arginine4410.0DNAH8, DSPP, NTS, MLN, SCT, CCK
49thyroxine44 2411.0CSN1S1, DNAH8, NTS, GAST, MLN, SCT
50domperidone44 28 1112.0HRH2, CYP3A4, GAST, MLN

GO Terms for genes affiliated with Gastroesophageal Reflux Disease

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Sources:
16Gene Ontology
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Cellular components related to Gastroesophageal Reflux Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.0NTS, MLN, GAST, SCT, CSN1S1, S100A8

Biological processes related to Gastroesophageal Reflux Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1feeding behaviorGO:00763110.4CCKAR, PYY, GCG
2heterocycle metabolic processGO:04648310.4CYP2C19, CYP3A4
3monoterpenoid metabolic processGO:01609810.3CYP2C19, CYP3A4
4G-protein coupled receptor signaling pathwayGO:00718610.2MLN, GAST, PYY, GCG
5exogenous drug catabolic processGO:04273810.1CYP3A4, CYP2C19

Molecular functions related to Gastroesophageal Reflux Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid hydroxylase activityGO:00839510.4CYP3A4, CYP2C19
2hormone activityGO:00517910.0MLN, GCG, PYY, CCK, SCT, GAST
3neuropeptide hormone activityGO:00518410.0NTS, CCK, PYY

Products for genes affiliated with Gastroesophageal Reflux Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gastroesophageal Reflux Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet