MCID: GST078
MIFTS: 35

Gastrointestinal Allergy

Categories: Immune diseases, Gastrointestinal diseases

Aliases & Classifications for Gastrointestinal Allergy

MalaCards integrated aliases for Gastrointestinal Allergy:

Name: Gastrointestinal Allergy 12 51 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0060502
UMLS 69 C0221034

Summaries for Gastrointestinal Allergy

Disease Ontology : 12 A hypersensitivity reaction type I disease located in the gastrointestinal tract.

MalaCards based summary : Gastrointestinal Allergy is related to schistosomiasis and pemphigoid gestationis. An important gene associated with Gastrointestinal Allergy is CCL11 (C-C Motif Chemokine Ligand 11), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include testes, skin and breast, and related phenotypes are hematopoietic system and immune system

Related Diseases for Gastrointestinal Allergy

Diseases related to Gastrointestinal Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 126)
# Related Disease Score Top Affiliating Genes
1 schistosomiasis 27.9 CD79A IGHE IL4 IL5 RNASE3
2 pemphigoid gestationis 10.5 CCL11 IL5
3 enteropathy-associated t-cell lymphoma 10.5 CCL11 ITGAE
4 chronic meningitis 10.5 CCL11 IL5
5 vulvovaginitis 10.5 CCL11 CCL5
6 ascaris lumbricoides infection 10.4 IL5 TSLP
7 respiratory syncytial virus infectious disease 10.4 CCL5 IL5
8 loeffler endocarditis 10.4 IL5 RNASE3
9 paragonimiasis 10.3 IL5 RNASE3
10 esophagitis 10.3 CCL11 IL5 TSLP
11 papillary conjunctivitis 10.3 CCL11 IL4
12 giant papillary conjunctivitis 10.3 CCL11 IL4
13 blepharitis 10.3 CCL11 IL4
14 cold urticaria 10.3 CMA1 RNASE3
15 radiculopathy 10.3 CCL11 CCL5 IL5
16 trichinosis 10.3 IL4 IL5
17 non-suppurative otitis media 10.3 IL4 IL5
18 scleritis 10.3 IL4 IL5
19 apple allergy 10.3 IL4 IL5
20 sinusitis 10.2 IL5 RNASE3
21 cercarial dermatitis 10.2 IL4 IL5
22 pneumonia 10.2 CCL11 CCL5 IL5
23 intestinal schistosomiasis 10.2 IL4 IL5
24 cellulitis 10.2 IL5 RNASE3
25 chronic tic disorder 10.2 IL4 IL5
26 eosinophilic gastroenteritis 10.2 CCL11 IL5 RNASE3
27 cryptosporidiosis 10.2 CCL11 CD79A
28 angiostrongyliasis 10.2 CCL11 IL4 IL5
29 eosinophilic meningitis 10.1 CCL11 IL4 IL5
30 non-secretory myeloma 10.1 CD79A ITGAE
31 anterior scleritis 10.1 CD79A IL5
32 status asthmaticus 10.1 CCL5 IL5 RNASE3
33 chronic interstitial cystitis 10.1 CD79A RNASE3
34 anisakiasis 10.1 CD79A RNASE3
35 urticaria 10.1 AOC1 CMA1 RNASE3
36 inclusion conjunctivitis 10.1 CCL5 CD79A
37 strongyloidiasis 10.1 CCL11 CD79A IL5
38 genital herpes 10.1 CCL5 IL4
39 immunoglobulin a deficiency 1 10.1 CD79A IL4
40 small intestine lymphoma 10.0 CD79A ITGAE
41 parasitic ichthyosporea infectious disease 10.0 CD79A IL4
42 congenital hypogammaglobulinemia 10.0 CD79A IL4
43 rhinosporidiosis 10.0 CD79A IL4
44 allergic contact dermatitis 10.0 IL33 IL4 IL5
45 esophagitis, eosinophilic, 1 10.0 CCL11 IL5 RNASE3 TSLP
46 cough variant asthma 10.0 IL4 IL5 RNASE3
47 pustulosis palmaris et plantaris 10.0 CD79A IL5
48 intrinsic asthma 10.0 IL4 IL5 RNASE3
49 inflammatory bowel disease 4 10.0 IL4 IL5 RNASE3
50 urinary schistosomiasis 10.0 IL4 IL5 RNASE3

Graphical network of the top 20 diseases related to Gastrointestinal Allergy:



Diseases related to Gastrointestinal Allergy

Symptoms & Phenotypes for Gastrointestinal Allergy

MGI Mouse Phenotypes related to Gastrointestinal Allergy:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.9 AOC1 CCL11 CCL5 CD79A CMA1 CRLF2
2 immune system MP:0005387 9.65 TSLP CCL11 CCL5 CD79A CMA1 CRLF2
3 respiratory system MP:0005388 9.1 TSLP CCL11 CRLF2 IL33 IL4 IL5

Drugs & Therapeutics for Gastrointestinal Allergy

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study to Identify Non-Invasive Markers of Gastrointestinal Allergy Completed NCT00272818 Phase 1

Search NIH Clinical Center for Gastrointestinal Allergy

Genetic Tests for Gastrointestinal Allergy

Anatomical Context for Gastrointestinal Allergy

MalaCards organs/tissues related to Gastrointestinal Allergy:

38
Testes, Skin, Breast

Publications for Gastrointestinal Allergy

Articles related to Gastrointestinal Allergy:

(show all 23)
# Title Authors Year
1
IL-33 promotes gastrointestinal allergy in a TSLP-independent manner. ( 29067997 )
2017
2
Effect of raw milk on allergic responses in a murine model of gastrointestinal allergy. ( 24870507 )
2014
3
Dietary elimination of children with food protein induced gastrointestinal allergy - micronutrient adequacy with and without a hypoallergenic formula? ( 25328667 )
2014
4
Guidance for the nutrition management of gastrointestinal allergy in pediatrics. ( 24565537 )
2013
5
Thymic stromal lymphopoietin is required for gastrointestinal allergy but not oral tolerance. ( 20600023 )
2010
6
Experimental gastrointestinal allergy enhances pulmonary responses to specific and unrelated allergens. ( 16890767 )
2006
7
Gastrointestinal allergy in adults. ( 16292080 )
2005
8
Revisiting the "hygiene hypothesis" in gastrointestinal allergy. ( 17033352 )
2002
9
Gastrointestinal allergy: clinical symptoms and immunological mechanisms. ( 11380898 )
2001
10
A critical role for eotaxin in experimental oral antigen-induced eosinophilic gastrointestinal allergy. ( 10841566 )
2000
11
The involvement of the histamine degradation pathway by diamine oxidase in manifest gastrointestinal allergies. ( 10350171 )
1999
12
Anti-schistosomal IgE and its relation to gastrointestinal allergy in breast-fed infants of Schistosoma mansoni infected mothers. ( 9707682 )
1998
13
Gastrointestinal allergy to food: a review. ( 9661317 )
1997
14
Analysis and characteristics of mast cell tryptase and eosinophilic cationic protein from human gut mucosa in gastrointestinal allergy. ( 8813193 )
1996
15
Gastrointestinal allergy. ( 7975041 )
1994
16
Food allergens as causative factors of respiratory, skin and gastrointestinal allergy confirmed by skin prick test and specific IgE and IgG4 FAST in children. ( 1292838 )
1992
17
Malrotation in children with symptoms of gastrointestinal allergy and psychosomatic abdominal pain. ( 3993380 )
1985
18
Cromolyn in combined gastrointestinal allergy. ( 6771419 )
1980
19
Childhood gastrointestinal allergy: forbidden fruits. ( 6902927 )
1980
20
Use of cromolyn in combined gastrointestinal allergy. ( 112265 )
1979
21
Gastrointestinal allergy to soyabean protein in preruminant calves. Allergenic constituents of soyabean products. ( 575571 )
1979
22
Gastrointestinal allergy to soyabean protein in preruminant calves. Antibody production and digestive disturbances in calves fed heated soyabean flour. ( 575570 )
1979
23
Protein-losing enteropathy associated with gastrointestinal allergy. ( 4168025 )
1967

Variations for Gastrointestinal Allergy

Expression for Gastrointestinal Allergy

Search GEO for disease gene expression data for Gastrointestinal Allergy.

Pathways for Gastrointestinal Allergy

Pathways related to Gastrointestinal Allergy according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.8 AOC1 CCL11 CCL5 CD79A IGHE IL33
2
Show member pathways
13.11 CCL11 CCL5 IGHE IL33 IL4 IL5
3
Show member pathways
12.62 CCL11 IL4 IL5 RNASE3
4
Show member pathways
12.33 CD79A IGHE IL4 IL5
5
Show member pathways
12.05 CRLF2 IL4 IL5 TSLP
6 11.78 CD79A IL4 IL5
7 11.74 CCL11 IGHE IL4
8 11.43 IL4 IL5 ITGAE
9 11.42 CCL11 IGHE IL4 IL5
10 11.35 CCL11 CCL5 CMA1 IL4 IL5
11 11.1 IL4 IL5
12 11.06 IL33 IL4 IL5 TSLP
13 11.04 IL4 IL5
14 11.02 CCL11 CRLF2 IL33 IL4 IL5
15 11 CRLF2 IL33 IL4 IL5 ITGAE TSLP
16 10.97 IL4 IL5
17 10.94 CCL11 CCL5 IL4 IL5
18 10.76 CCL11 CCL5 IL4 IL5 ITGAE
19 10.56 IL4 IL5

GO Terms for Gastrointestinal Allergy

Cellular components related to Gastrointestinal Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 AOC1 CCL11 CCL5 IL33 IL4 IL5
2 extracellular region GO:0005576 9.36 AOC1 CCL11 CCL5 CMA1 CRLF2 IGHE

Biological processes related to Gastrointestinal Allergy according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.72 CCL11 CCL5 IGHE IL4 IL5
2 chemotaxis GO:0006935 9.69 CCL11 CCL5 IL4
3 B cell activation GO:0042113 9.52 CD79A IL4
4 positive regulation of JAK-STAT cascade GO:0046427 9.49 CCL5 IL5
5 positive regulation of immunoglobulin secretion GO:0051024 9.48 IL33 IL5
6 eosinophil chemotaxis GO:0048245 9.46 CCL11 CCL5
7 positive regulation of interleukin-5 production GO:0032754 9.43 IL33 TSLP
8 regulation of receptor activity GO:0010469 9.43 CCL11 CCL5 IL33 IL4 IL5 TSLP
9 positive regulation of interleukin-5 secretion GO:2000664 9.4 CRLF2 TSLP
10 type 2 immune response GO:0042092 9.37 IL33 IL4
11 positive regulation of mast cell activation GO:0033005 9.26 CRLF2 TSLP
12 positive regulation of STAT cascade GO:1904894 9.16 CRLF2 TSLP
13 positive regulation of interleukin-13 production GO:0032736 8.8 IL33 IL4 TSLP

Molecular functions related to Gastrointestinal Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 CCL11 CCL5 IL33 IL4 IL5 TSLP

Sources for Gastrointestinal Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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