MCID: GST014
MIFTS: 49

Gastrointestinal Lymphoma malady

Gastrointestinal diseases, Immune diseases categories

Summaries for Gastrointestinal Lymphoma

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32MalaCards
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MalaCards: Gastrointestinal Lymphoma is related to sarcoma and gastric lymphoma. An important gene associated with Gastrointestinal Lymphoma is NBN (nibrin), and among its related pathways are Fanconi Anemia pathway and Glioma. The compounds cycloheximide and tamoxifen have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and lymph node, and related mouse phenotypes are tumorigenesis and vision/eye.

Aliases & Classifications for Gastrointestinal Lymphoma

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Immune diseases


Aliases & Descriptions:

gastrointestinal lymphoma 8 10 60


External Ids:

Disease Ontology8 DOID:903
NCIt39 C38162

Related Diseases for Gastrointestinal Lymphoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Gastrointestinal Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 118)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma29.9TP53
2gastric lymphoma10.1
3pediatric lymphoma10.1
4heavy chain disease10.1
5hodgkin's lymphoma10.1
6inflammatory bowel disease10.1
7gastrointestinal stromal tumor10.0IFI27
8smooth muscle tumor10.0IFI27
9leukoplakia10.0IFI27
10cervical intraepithelial neoplasia10.0IFI27
11pituitary adenoma10.0IFI27
12thymoma10.0IFI27
13pituitary tumors10.0IFI27
14ischemia10.0CASP7
15multiple sclerosis10.0CASP8
16hepatitis10.0CASP8
17keratoacanthoma10.0CDKN1A
18nijmegen breakage syndrome10.0NBN
19monocytic leukemia10.0CASP8
20molluscum contagiosum10.0CASP8
21tongue cancer10.0CDKN1A
22acute leukemia10.0CASP8
23werner syndrome10.0NBN
24renal clear cell carcinoma10.0CASP8
25hepatitis b10.0CASP8
26fanconi's anemia10.0NBN
27cervical squamous cell carcinoma10.0CDKN1A
28lichen sclerosus10.0CD44
29thoracic cancer10.0CDKN1A
30asthma10.0CASP8
31atherosclerosis10.0IFI27
32cervical adenocarcinoma10.0IFI27, CDKN1A
33arthritis10.0CD44
34mycosis fungoides10.0TRG
35fibrosarcoma10.0CASP7, CDKN1A
36gallbladder cancer10.0TP53
37neuroblastoma10.0TP53
38leiomyosarcoma10.0TP53
39parathyroid carcinoma10.0CCND1
40esophageal squamous cell carcinoma10.0IFI27, CCND1
41tuberous sclerosis10.0IFI27
42lynch syndrome10.0TP53
43ulcerative colitis10.0TP53
44cholangiocarcinoma10.0TP53
45lymphoma, small cleaved-cell, diffuse10.0BCL2, CCND1
46medulloblastoma10.0CASP8, TP53
47rhabdomyosarcoma10.0CASP8, TP53
48malt lymphoma10.0CCND1, BCL2
49mantle cell lymphoma10.0BCL2, CCND1
50multiple myeloma10.0CD44, CCND1

Graphical network of the top 20 diseases related to Gastrointestinal Lymphoma:



Diseases related to gastrointestinal lymphoma

Clinical Features for Gastrointestinal Lymphoma

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Drugs & Therapeutics for Gastrointestinal Lymphoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Gastrointestinal Lymphoma

Drug clinical trials:

Search ClinicalTrials for Gastrointestinal Lymphoma

Search NIH Clinical Center for Gastrointestinal Lymphoma

Search CenterWatch for Gastrointestinal Lymphoma

Genetic Tests for Gastrointestinal Lymphoma

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Anatomical Context for Gastrointestinal Lymphoma

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32MalaCards
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MalaCards organs/tissues related to Gastrointestinal Lymphoma:

32
B cells, T cells, Lymph node, Colon, Thyroid, Appendix

Animal Models for Gastrointestinal Lymphoma or affiliated genes

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Sources:
36MGI
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Publications for Gastrointestinal Lymphoma

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Sources:
50PubMed
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Articles related to Gastrointestinal Lymphoma:

(show top 50)    (show all 202)
idTitleAuthorsYear
1
Endoscopic appearance of AIDS-related gastrointestinal lymphoma with c-MYC rearrangements: case report and literature review. (23922484)
2013
2
Clinically undiagnosed enteropathy associated T-cell lymphoma type II presenting with prolonged lower gastrointestinal tract symptoms: report of an autopsy case and review of diagnostic challenges and clinicopathological correlation. (23450273)
2013
3
Primary follicular lymphoma of the gastrointestinal tract: effect of stage, symptoms and treatment choice on outcome. (22642933)
2013
4
Sonographic features of gastrointestinal lymphoma in 15 dogs. (23888986)
2013
5
Gastrointestinal follicular lymphoma with lymphoepithelial lesions. (24149616)
2013
6
Detection and clinical significance of genes in primary gastrointestinal MALT lymphoma. (24272086)
2013
7
Education and Imaging. Gastrointestinal: Unusual duodenal follicular lymphoma observed by magnifying endoscopy with narrow-band imaging. (23875635)
2013
8
Usefulness of HGAL and LMO2 immunohistochemistry in the identification of follicular lymphomas of the non-gastric gastrointestinal tract. (22914613)
2013
9
Education and imaging. Gastrointestinal: MALT lymphoma of the small bowel accompanied by NSAID-induced enteropathy. (22621456)
2012
10
Primary gastrointestinal follicular lymphoma: single-center 12-year experiences. (22020908)
2012
11
Simultaneous primary gastric and duodenal MALT lymphoma presenting with gastrointestinal bleeding. (23007819)
2012
12
Gastrointestinal B-cell lymphomas: From understanding B-cell physiology to classification and molecular pathology. (23443141)
2012
13
Feline gastrointestinal lymphoma: mucosal architecture, immunophenotype, and molecular clonality. (21505197)
2012
14
Gastrointestinal lymphoma: a spectrum of fluoroscopic and CT findings. (20725903)
2011
15
Prevalence of API2-MALT1 fusion gene in gastrointestinal mucosa-associated lymphoid tissue lymphomas and diffuse large B cell lymphomas]. (20079017)
2009
16
Gastrointestinal stromal tumor with autonomic nerve differentiation and coexistent mantle cell lymphoma involving the appendix. (19636397)
2009
17
Composite gastrointestinal lymphoma consisting of diffuse large B-cell lymphoma and peripheral T-cell lymphoma. (19588220)
2009
18
Diagnosis and treatment of 81 patients with primary gastrointestinal lymphoma. (19648667)
2009
19
What to do when you suspect gastrointestinal lymphoma: a pathologist's perspective. (17336592)
2007
20
Primary gastrointestinal lymphoma--a clinicopathologic study. (17883049)
2007
21
Gastric MALT lymphoma in the absence of Helicobacter pylori infection presenting as an upper gastrointestinal hemorrhage. (17100037)
2006
22
Increased risk of gastrointestinal lymphoma in carriers of the 657del5 NBS1 gene mutation. (16998789)
2006
23
Images of interest. Gastrointestinal: Burkitt's lymphoma. (16174083)
2005
24
Clinico-pathological features and outcome of management of pediatric gastrointestinal lymphoma. (17102814)
2005
25
Gastrointestinal lymphoma: where morphology meets molecular biology. (15643667)
2005
26
Expression of BCL-10 in gastrointestinal mucosa-associated lymphoid tissue lymphoma]. (15634591)
2004
27
Occurrence of a myelodysplastic syndrome (MDS) during first-line 2-chloro-deoxyadenosine (2-CDA) treatment of a low-grade gastrointestinal MALT lymphoma. Case report and review of the literature. (15075093)
2004
28
AIDS-associated gastrointestinal lymphoma: is there a role for surgery in the standard of care? (14600583)
2003
29
CT findings in peripheral T-cell lymphoma involving the gastrointestinal tract. (12601189)
2003
30
Interleukin 8 and Flt3 ligand as markers of advanced disease in primary gastrointestinal non-Hodgkin's lymphoma. (11956621)
2002
31
Primary gastrointestinal non-Hodgkin's lymphoma: II. Combined surgical and conservative or conservative management only in localized gastric lymphoma--results of the prospective German Multicenter Study GIT NHL 01/92. (11559725)
2001
32
Gastrointestinal lymphoma: prevention and treatment of early lesions. (11355919)
2001
33
Complete remission of generalized relapsed extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type of the gastrointestinal tract after high-dose chemotherapy and autologous peripheral stem cell transplantation. (11195010)
2000
34
Value of barium studies for predicting primary versus secondary non-Hodgkin's gastrointestinal lymphoma. (10926188)
2000
35
Epstein-Barr virus-associated primary gastrointestinal lymphoma in non-immunocompromised patients in Korea. (9088952)
1997
36
Gastrointestinal lymphoma in adults: clinical features and management of 300 cases. (8143991)
1994
37
Immunoglobulin specificity of low grade B cell gastrointestinal lymphoma of mucosa-associated lymphoid tissue (MALT) type. (8424461)
1993
38
Bcl-2 gene rearrangements in primary B-cell lymphoma of the gastrointestinal tract reveal follicular lymphoma as a subtype. (8426481)
1993
39
Biclonal gammopathy--report of a case with primary gastrointestinal lymphoma. (1845345)
1991
40
Primary gastrointestinal lymphoma in childhood (up to 18 years of age). A morphological, immunohistochemical and clinical study. (2324163)
1990
41
Genomic analysis of T-cell receptor and immunoglobulin antigen receptor genes and breakpoint cluster regions in gastrointestinal lymphomas. (2249841)
1990
42
Gastrointestinal lymphoma in 20 dogs. A retrospective study. (2715959)
1989
43
Gastrointestinal lymphoma and sarcoma. A case for aggressive search and destroy. (3592804)
1987
44
Primary gastrointestinal lymphoma complicated by common bile duct obstruction: report of two cases. (3526871)
1986
45
Primary gastrointestinal lymphoma. (4023780)
1985
46
Primary gastrointestinal lymphoma in Thailand. (3897434)
1985
47
Gastrointestinal lymphoma with total involvement of the gut--report of one case. (6549075)
1984
48
Gastrointestinal mucosa and primary gastrointestinal lymphoma. (109421)
1979
49
New presentation of alpha heavy chain disease: North American polypoid gastrointestinal lymphoma. Clinical and cellular studies. (416900)
1978
50
Primary gastrointestinal lymphoma in the Sudan. (933093)
1976

Genetic Variations for Gastrointestinal Lymphoma

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Expression for genes affiliated with Gastrointestinal Lymphoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Gastrointestinal Lymphoma

Search GEO for disease gene expression data for Gastrointestinal Lymphoma.

Pathways for genes affiliated with Gastrointestinal Lymphoma

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Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG, 55SinoBiological, 51QIAGEN, 12EMD Millipore, 59Tocris Bioscience, 4Cell Signaling Technology, 52R&D Systems
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Pathways related to Gastrointestinal Lymphoma according to GeneCards/GeneDecks:

(show top 50)    (show all 55)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.7TP53, NBN
2
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9.7CDKN1A, TP53
3
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9.7TP53, CDKN1A
4
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9.7CASP7
5
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9.6BCL2, TP53
69.4CCND1, CDKN1A, BCL2
79.4CCND1, CDKN1A, BCL2
89.4TP53, CDKN1A, CCND1
9
Hide members
9.4TP53, CDKN1A, CCND1
109.4TP53, CDKN1A, CCND1
119.4TP53, CDKN1A, CCND1
12
Hide members
9.4CCND1, CDKN1A, TP53
13
Hide members
9.4CCND1, CDKN1A, TP53
14
Hide members
9.4TP53, CDKN1A, CCND1
15
Transcription P53 signaling pathway
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9.3TP53, BCL2, CDKN1A
169.3CDKN1A, BCL2, TP53
179.3CDKN1A, BCL2, TP53
189.3CCND1, BCL2, TP53
199.1CCND1, CDKN1A, NBN, TP53
209.1TP53, CDKN1A, CASP8, CCND1
21
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9.0CASP8, CASP7, CCND1
229.0CCND1, CD44, CDKN1A, TP53
239.0CCND1, CD44, CDKN1A, TP53
24
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9.0CCND1, CASP8, BCL2, TP53
259.0CCND1, CASP8, BCL2, TP53
268.9CCND1, CDKN1A, BCL2, TP53
27
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8.9CCND1, CDKN1A, BCL2, TP53
28
Apoptosis and survival Caspase cascade
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8.9CASP7, CASP8, BCL2
29
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8.9BCL2, CASP8, CASP7
30
Hide members
8.9BCL2, CASP8, CASP7
318.9CASP7, CASP8, BCL2
32
Hide members
8.9CASP7, CASP8, BCL2
33
Hide members
8.9CASP7, CASP8, BCL2
348.9CASP7, CASP8, BCL2
358.9CASP7, CASP8, BCL2
368.9TP53, BCL2, CDKN1A, CD44
378.9CD44, CDKN1A, BCL2, TP53
38
Hide members
8.8CCND1, CASP8, CDKN1A, NBN, TP53
39
Hide members
8.7CDKN1A, CASP8, CASP7, CCND1
408.6CCND1, CASP8, CDKN1A, BCL2, TP53
41
Hide members
8.6CCND1, CASP8, CDKN1A, BCL2, TP53
428.6TP53, BCL2, CDKN1A, CD44, CCND1
43
Hide members
8.6CCND1, CD44, CDKN1A, BCL2, TP53
448.5TP53, BCL2, CDKN1A, CASP7
45
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8.3BCL2, CDKN1A, CASP8, CASP7, CCND1
46
Apoptosis and survival Apoptotic TNF-family pathways
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8.2CASP7, CASP8, CDKN1A, BCL2, TP53
47
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8.2CASP7, CASP8, CDKN1A, BCL2, TP53
48
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8.1CASP7, CASP8, CD44, BCL2, TP53
49
Hide members
7.8CCND1, CASP7, CASP8, CDKN1A, BCL2, TP53
507.8TP53, BCL2, CDKN1A, CASP8, CASP7, CCND1

Compounds for genes affiliated with Gastrointestinal Lymphoma

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Sources:
44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 24HMDB
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Compounds related to Gastrointestinal Lymphoma according to GeneCards/GeneDecks:

(show top 50)    (show all 145)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.5CASP8
2tamoxifen44 49 28 1113.2CDKN1A, CCND1
3depsipeptide4410.1CCND1, TP53
4optimax449.5CCND1, CDKN1A, IFI27
5serine449.5CCND1, CD44, NBN
6sulindac sulfide449.3TP53, BCL2, CASP8, CCND1
7sulforaphane449.3CCND1, CDKN1A, BCL2, CASP8
8noxa449.2CDKN1A, BCL2, CASP8, TP53
9olomoucine44 1110.1CASP8, CCND1, CDKN1A, BCL2, TP53
10eb 108944 5910.0CCND1, BCL2, CDKN1A, IFI27
11suberoylanilide hydroxamic acid449.0CCND1, CASP8, BCL2, TP53, CDKN1A
122-methoxyestradiol44 59 2411.0CCND1, CDKN1A, BCL2, TP53, CASP8
13n-(4-hydroxyphenyl)retinamide449.0BCL2, CDKN1A, CCND1, TP53, CASP8
14arsenite44 2410.0BCL2, CDKN1A, CASP8, CCND1, TP53
15flavopiridol44 1110.0CCND1, TP53, BCL2, CDKN1A, CASP8
1610-hydroxycamptothecin449.0TP53, CDKN1A, BCL2
17gemcitabine44 49 1111.0CASP8, TP53, BCL2, CDKN1A, CCND1
18lactacystin449.0CCND1, CDKN1A, CASP8, BCL2, TP53
19paraffin449.0IFI27, BCL2, CDKN1A, CD44
20z-vad-fmk44 599.8CASP8, BCL2, TP53, CASP7
21mevastatin44 28 1110.8CASP8, CASP7, CDKN1A, IFI27
22curcumin448.7BCL2, CASP8, CCND1, TP53, CDKN1A
23etoposide44 49 59 1111.7NBN, BCL2, CD44, CASP8, CASP7
24troglitazone44 28 59 1111.7CCND1, CASP8, IFI27, CDKN1A, BCL2
25adriamycin448.7CCND1, TP53, BCL2, CASP8, CD44, CDKN1A
26thymidylate448.6IFI27, CCND1, CDKN1A, TP53, BCL2
27topotecan44 119.6CASP7, CASP8, BCL2, TP53
28cd 437448.6CASP8, CASP7, CDKN1A, TP53, BCL2
29dutp448.5CCND1, CASP7, CASP8, BCL2, TP53
30indole-3-carbinol448.5CCND1, CASP8, TP53, IFI27, CDKN1A, BCL2
31sulindac44 119.5BCL2, CCND1, CASP8, TP53, IFI27, CDKN1A
32roscovitine448.5BCL2, CDKN1A, IFI27, CCND1, TP53, CASP8
33docetaxel44 49 59 1111.4CASP7, CASP8, CDKN1A, BCL2, TP53
34retinoid448.4TP53, IFI27, BCL2, CDKN1A, CASP8, CCND1
35camptothecin44 59 1110.3TP53, CASP7, BCL2, NBN, CDKN1A, CASP8
36bortezomib44 119.2CASP8, CDKN1A, CCND1, BCL2, CASP7, TP53
37sp 60012544 599.2TP53, BCL2, CDKN1A, CASP8, CASP7, CCND1
38cytarabine44 49 1110.1TP53, BCL2, IFI27, CDKN1A, CASP7
39phosphatidylserine44 28 1110.1TP53, BCL2, CD44, CASP7, CASP8
40paclitaxel44 49 1110.1CCND1, IFI27, TP53, BCL2, CD44, CDKN1A
415fluorouracil448.1BCL2, CASP7, CASP8, TP53, CDKN1A
42adpribose447.6CASP7, CASP8, IFI27, CDKN1A, BCL2, TP53
43mg 13244 598.6IFI27, CCND1, CASP7, CASP8, CDKN1A, BCL2
44progesterone44 59 28 11 2411.4BCL2, CDKN1A, CASP7, CD44, IFI27, TP53
45n acetylcysteine447.4CASP7, TP53, IFI27, CASP8, BCL2, NBN
46vegf447.3TP53, BCL2, IFI27, CASP7, CCND1, CD44
47ly294002447.3IFI27, TP53, BCL2, CD44, CDKN1A, CCND1
48cisplatin44 49 59 1110.2CASP8, CD44, CDKN1A, BCL2, CASP7, CCND1
49retinoic acid44 248.2TP53, CCND1, CASP8, CASP7, IFI27, CDKN1A
50doxorubicin44 49 119.0CDKN1A, NBN, BCL2, CD44, TP53, IFI27

GO Terms for genes affiliated with Gastrointestinal Lymphoma

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Sources:
16Gene Ontology
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Cellular components related to Gastrointestinal Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein kinase holoenzyme complexGO:0003079.8CDKN1A, CCND1
2replication forkGO:0056579.4NBN, TP53
3mitochondrial outer membraneGO:0057419.0BCL2, IFI27, CASP8
4nucleoplasmGO:0056548.2TP53, NBN, CDKN1A, CASP7, CCND1

Biological processes related to Gastrointestinal Lymphoma according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1response to organonitrogen compoundGO:01024310.1CDKN1A, CCND1
2response to corticosterone stimulusGO:05141210.1CDKN1A, CCND1
3response to iron ionGO:01003910.1BCL2, CCND1
4DNA damage response, signal transduction by p53 class mediatorGO:03033010.0NBN, TP53
5mitotic cell cycle arrestGO:07185010.0TP53, CDKN1A
6mitotic G1 DNA damage checkpointGO:03157110.0CCND1, TP53
7positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayGO:190074010.0BCL2, CASP8
8B cell lineage commitmentGO:00232610.0TP53, BCL2
9response to X-rayGO:0101659.9TP53, CCND1
10regulation of mitochondrial membrane permeabilityGO:0469029.9TP53, BCL2
11cellular response to ionizing radiationGO:0714799.9CDKN1A, TP53
12positive regulation of intrinsic apoptotic signaling pathwayGO:20012449.8BCL2, TP53
13positive regulation of reactive oxygen species metabolic processGO:20003799.8TP53, CDKN1A
14cell agingGO:0075699.8BCL2, TP53
15response to gamma radiationGO:0103329.7TP53, BCL2
16response to antibioticGO:0466779.7CASP8, TP53
17cell cycle arrestGO:0070509.7TP53, NBN, CDKN1A
18negative regulation of cell growthGO:0303089.6TP53, BCL2, CDKN1A
19T cell differentiation in thymusGO:0330779.5TP53, BCL2
20neuron apoptotic processGO:0514029.3TP53, BCL2
21response to DNA damage stimulusGO:0069749.3CCND1, CDKN1A, BCL2, TP53
22release of cytochrome c from mitochondriaGO:0018369.2CASP7, BCL2, TP53
23negative regulation of apoptotic processGO:0430669.2CD44, CDKN1A, BCL2, TP53
24heart developmentGO:0075079.1CASP7, CASP8, ADAP2
25apoptotic processGO:0069158.7BCL2, NBN, CASP8, CASP7
26intrinsic apoptotic signaling pathwayGO:0971938.5TP53, BCL2, CDKN1A, CASP8, CASP7

Molecular functions related to Gastrointestinal Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein phosphatase 2A bindingGO:0517219.6TP53, BCL2
2protease bindingGO:0020209.2TP53, BCL2, CASP8
3protein bindingGO:0055156.3CCND1, CASP7, CASP8, CD44, CDKN1A, NBN

Products for genes affiliated with Gastrointestinal Lymphoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gastrointestinal Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet