MCID: GST014
MIFTS: 44

Gastrointestinal Lymphoma malady

Gastrointestinal, Immune categories

Summaries for Gastrointestinal Lymphoma

Sources:
33MalaCards
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MalaCards: Gastrointestinal Lymphoma is related to lymphoma, diffuse large cell and b-cell lymphomas. An important gene associated with Gastrointestinal Lymphoma is NBN (nibrin), and among its related pathways are Fanconi Anemia pathway and Glioma. The compounds cycloheximide and tamoxifen have been mentioned in the context of this disorder. Affiliated tissues include lymph node, small intestine and colon, and related mouse phenotypes are tumorigenesis and vision/eye.

Aliases & Classifications for Gastrointestinal Lymphoma

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 40NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal, Immune


Aliases & Descriptions:

gastrointestinal lymphoma 8 10 61


External Ids:

Disease Ontology8 DOID:903
NCIt40 C38162

Related Diseases for Gastrointestinal Lymphoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Gastrointestinal Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1lymphoma, diffuse large cell29.9BCL2, CD44
2b-cell lymphomas29.8CCND1, CASP8, IFI27, TRG, CD44, CDKN1A
3gastric lymphoma10.1
4pediatric lymphoma10.1
5gastrointestinal stromal tumor10.0IFI27
6smooth muscle tumor10.0IFI27
7leukoplakia10.0IFI27
8cervical intraepithelial neoplasia10.0IFI27
9pituitary adenoma10.0IFI27
10thymoma10.0IFI27
11pituitary tumors10.0IFI27
12ischemia10.0CASP7
13multiple sclerosis10.0CASP8
14hepatitis10.0CASP8
15keratoacanthoma10.0CDKN1A
16nijmegen breakage syndrome10.0NBN
17monocytic leukemia10.0CASP8
18molluscum contagiosum10.0CASP8
19tongue cancer10.0CDKN1A
20acute leukemia10.0CASP8
21werner syndrome10.0NBN
22renal clear cell carcinoma10.0CASP8
23hepatitis b10.0CASP8
24fanconi's anemia10.0NBN
25cervical squamous cell carcinoma10.0CDKN1A
26lichen sclerosus10.0CD44
27thoracic cancer10.0CDKN1A
28asthma10.0CASP8
29atherosclerosis10.0IFI27
30cervical adenocarcinoma10.0IFI27, CDKN1A
31arthritis10.0CD44
32mycosis fungoides10.0TRG
33fibrosarcoma10.0CASP7, CDKN1A
34gallbladder cancer10.0TP53
35sarcoma10.0TP53
36neuroblastoma10.0TP53
37skin cancer10.0TP53
38leiomyosarcoma10.0TP53
39parathyroid carcinoma10.0CCND1
40esophageal squamous cell carcinoma10.0IFI27, CCND1
41tuberous sclerosis10.0IFI27
42lynch syndrome10.0TP53
43ulcerative colitis10.0TP53
44cholangiocarcinoma10.0TP53
45lymphoma, small cleaved-cell, diffuse10.0BCL2, CCND1
46medulloblastoma10.0CASP8, TP53
47rhabdomyosarcoma10.0CASP8, TP53
48lymphoma, malt, somatic10.0CCND1, BCL2
49mantle cell lymphoma10.0BCL2, CCND1
50multiple myeloma10.0CD44, CCND1

Graphical network of the top 20 diseases related to Gastrointestinal Lymphoma:



Diseases related to gastrointestinal lymphoma

Clinical Features for Gastrointestinal Lymphoma

Drugs & Therapeutics for Gastrointestinal Lymphoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Gastrointestinal Lymphoma

Drug clinical trials:

Search ClinicalTrials for Gastrointestinal Lymphoma

Search NIH Clinical Center for Gastrointestinal Lymphoma

Search CenterWatch for Gastrointestinal Lymphoma

Genetic Tests for Gastrointestinal Lymphoma

Anatomical Context for Gastrointestinal Lymphoma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Gastrointestinal Lymphoma:

33
Lymph node, Small intestine, Colon, Thyroid, T cells, B cells, Appendix

Animal Models for Gastrointestinal Lymphoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Gastrointestinal Lymphoma

Sources:
51PubMed
See all sources

Articles related to Gastrointestinal Lymphoma:

(show top 50)    (show all 206)
idTitleAuthorsYear
1
Diffuse gastric mantle cell lymphoma resembling gastrointestinal stromal tumors. (24368075)
2013
2
Gastrointestinal lymphoma: recent advances in diagnosis and treatment. (23635497)
2013
3
High-resolution genomic profiling reveals clonal evolution and competition in gastrointestinal marginal zone B-cell lymphoma and its large cell variant. (22890838)
2013
4
The management of gastrointestinal follicular lymphoma: some observations on a rare disease. (22812508)
2013
5
Education and imaging. Gastrointestinal: Cavitating mesenteric lymph node syndrome as manifestation of anaplastic large cell lymphoma. (22260283)
2012
6
CT features of peripheral T-cell lymphoma in the gastrointestinal tract in Chinese population and literature review. (22498185)
2012
7
Expression of the Bcl-2 apoptotic marker in cats diagnosed with inflammatory bowel disease and gastrointestinal lymphoma. (22710860)
2012
8
Endoscopic findings in mantle cell lymphoma with gastrointestinal tract involvement. (22236942)
2012
9
Increasing incidence rates, distribution and histological characteristics of primary gastrointestinal non-Hodgkin lymphoma in a North American population. (22803021)
2012
10
Clinical features of gastrointestinal follicular lymphoma: comparison with nodal follicular lymphoma and gastrointestinal MALT lymphoma. (21266815)
2011
11
Primary gastrointestinal lymphoma. (21390139)
2011
12
Primary gastrointestinal diffuse large B cell lymphoma presenting with cold agglutinin disease. (21887126)
2011
13
The role of neuregulin4 and HER4 in gastrointestinal malignant lymphoma. (21805036)
2011
14
Mixed response in interim positron emission tomography/computed tomography leads to detection of a gastrointestinal stromal tumor in a patient with mediastinal diffuse large B-cell lymphoma. (20194849)
2010
15
Double-balloon endoscopy depicts diminutive small bowel lesions in gastrointestinal lymphoma. (19241169)
2010
16
Efficacy of combination chemotherapy for treatment of gastrointestinal lymphoma in dogs. (19192147)
2009
17
Imaging of gastrointestinal lymphoma. (18619382)
2008
18
What to do when you suspect gastrointestinal lymphoma: a pathologist's perspective. (17336592)
2007
19
Absence of CASP7 and CASP8 mutation in gastrointestinal lymphomas. (17532763)
2007
20
Education and imaging. Gastrointestinal: MALT lymphoma of the terminal ileum. (16911702)
2006
21
Expression of BCL-10 in gastrointestinal mucosa-associated lymphoid tissue lymphoma]. (15634591)
2004
22
Investigation of T-cell receptor-gamma gene rearrangement in gastrointestinal lymphomas by PCR-SSCP analysis. (15052681)
2004
23
Combination treatment of rituximab and imatinib mesylate for simultaneous relapse of MALT lymphoma and a gastrointestinal stromal tumor. (15512830)
2004
24
Epstein-Barr virus-associated peripheral T-cell lymphoma with gastrointestinal tract involvement. (14649966)
2003
25
Methylation analysis of cyclin-dependent kinase inhibitor genes in primary gastrointestinal lymphomas. (12920218)
2003
26
Primary gastric B-cell lymphoma: results of a prospective multicenter study. The German-Austrian Gastrointestinal Lymphoma Study Group. (11054376)
2000
27
Frequent mutation of bcl-6 proto-oncogene in high grade, but not low grade, MALT lymphomas of the gastrointestinal tract. (10406897)
1999
28
Differences in endoscopic and clinicopathological features of primary and secondary gastric non-Hodgkin's lymphoma. German Gastrointestinal Lymphoma Study Group. (10049413)
1999
29
p53 protein expression in gastrointestinal lymphomas. (8978599)
1997
30
Protocol for the examination of specimens removed from patients with gastrointestinal lymphoma. A basis for checklists. The Cancer Committee, College of American Pathologists, and the Task Force for Protocols on the Examination of Specimens From Patients With Gastrointestinal Lymphoma. (9341582)
1997
31
Primary gastrointestinal T-cell lymphoma resembling multiple lymphomatous polyposis. (8780585)
1996
32
Primary gastrointestinal lymphoma: 30-year experience at the Cancer Institute, Madras, India. (7666666)
1995
33
A case of neural cell adhesion molecule-positive peripheral T-cell lymphoma associated with human T-cell lymphotrophic virus type 1 showing an unusual involvement of the gastrointestinal tract during the course of the disease. (7959673)
1994
34
MRI manifestations of gastrointestinal lymphoma. (7820018)
1994
35
Immunoglobulin specificity of low grade B cell gastrointestinal lymphoma of mucosa-associated lymphoid tissue (MALT) type. (8424461)
1993
36
Lymphocyte homing receptor (CD44) expression is associated with poor prognosis in gastrointestinal lymphoma. (8347502)
1993
37
Bcl-2 gene rearrangements in primary B-cell lymphoma of the gastrointestinal tract reveal follicular lymphoma as a subtype. (8426481)
1993
38
Gastrointestinal lymphoma: a surgical perspective. (8420540)
1993
39
Peripheral T-cell lymphoma of AILD (angioimmunoblastic lymphadenopathy with dysproteinemia) type involving gastrointestinal tract. A morphologic, phenotypic and genotypic study. (1314007)
1992
40
CD30 (Ki-1)-positive, anaplastic large cell lymphoma mimicking gastrointestinal carcinoma. (1330283)
1992
41
Role of surgery in multimodality therapy for gastrointestinal lymphoma. (2031540)
1991
42
Gastrointestinal lymphoma: sonographic findings in 54 patients. (2119110)
1990
43
Lymphomatoid granulomatosis presenting as ulcerodestructive gastrointestinal tract lesions in patients with human immunodeficiency virus infection. A new association. (2244777)
1990
44
Immunophenotypic and genotypic characterization of primary non-Hodgkin's lymphoma of the gastrointestinal tract. (2217150)
1990
45
Gastrointestinal lymphoma. A case for primary surgical resection. (2378562)
1990
46
Gamma 3 heavy chain disease and monoclonal IgMk in a patient with a gastrointestinal lymphoma. (3924773)
1985
47
Primary gastrointestinal lymphoma in Kuwait. An 11-yr retrospective analysis of 108 cases. (4007022)
1985
48
Computed tomography of gastrointestinal lymphoma. (6603767)
1983
49
Lymphomatoid granulomatosis involving the gastrointestinal tract. Two case reports and a review of the literature. (6600693)
1983
50
Malignant lymphoma of Waldeyer's ring following gastrointestinal lymphoma. (6774806)
1980

Genetic Variations for Gastrointestinal Lymphoma

Expression for genes affiliated with Gastrointestinal Lymphoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Gastrointestinal Lymphoma

Search GEO for disease gene expression data for Gastrointestinal Lymphoma.

Pathways for genes affiliated with Gastrointestinal Lymphoma

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG, 56SinoBiological, 52QIAGEN, 12EMD Millipore, 60Tocris Bioscience, 4Cell Signaling Technology, 53R&D Systems
See all sources

Pathways related to Gastrointestinal Lymphoma according to GeneCards/GeneDecks:

(show top 50)    (show all 55)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.7TP53, NBN
2
Hide members
9.7CDKN1A, TP53
3
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9.7TP53, CDKN1A
4
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9.7CASP7
5
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9.6BCL2, TP53
69.4CCND1, CDKN1A, BCL2
79.4CCND1, CDKN1A, BCL2
89.4TP53, CDKN1A, CCND1
9
Hide members
9.4TP53, CDKN1A, CCND1
109.4TP53, CDKN1A, CCND1
119.4TP53, CDKN1A, CCND1
12
Hide members
9.4CCND1, CDKN1A, TP53
13
Hide members
9.4CCND1, CDKN1A, TP53
14
Hide members
9.4TP53, CDKN1A, CCND1
15
Transcription P53 signaling pathway
Hide members
9.3TP53, BCL2, CDKN1A
169.3CDKN1A, BCL2, TP53
179.3CDKN1A, BCL2, TP53
189.3CCND1, BCL2, TP53
199.1CCND1, CDKN1A, NBN, TP53
209.1TP53, CDKN1A, CASP8, CCND1
21
Hide members
9.0CASP8, CASP7, CCND1
229.0CCND1, CD44, CDKN1A, TP53
239.0CCND1, CD44, CDKN1A, TP53
24
Hide members
9.0CCND1, CASP8, BCL2, TP53
259.0CCND1, CASP8, BCL2, TP53
268.9CCND1, CDKN1A, BCL2, TP53
27
Hide members
8.9CCND1, CDKN1A, BCL2, TP53
28
Apoptosis and survival Caspase cascade
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8.9CASP7, CASP8, BCL2
29
Hide members
8.9BCL2, CASP8, CASP7
30
Hide members
8.9BCL2, CASP8, CASP7
318.9CASP7, CASP8, BCL2
32
Hide members
8.9CASP7, CASP8, BCL2
33
Hide members
8.9CASP7, CASP8, BCL2
348.9CASP7, CASP8, BCL2
358.9CASP7, CASP8, BCL2
368.9TP53, BCL2, CDKN1A, CD44
378.9CD44, CDKN1A, BCL2, TP53
38
Hide members
8.8CCND1, CASP8, CDKN1A, NBN, TP53
39
Hide members
8.7CDKN1A, CASP8, CASP7, CCND1
408.6CCND1, CASP8, CDKN1A, BCL2, TP53
41
Hide members
8.6CCND1, CASP8, CDKN1A, BCL2, TP53
428.6TP53, BCL2, CDKN1A, CD44, CCND1
43
Hide members
8.6CCND1, CD44, CDKN1A, BCL2, TP53
448.5TP53, BCL2, CDKN1A, CASP7
45
Hide members
8.3BCL2, CDKN1A, CASP8, CASP7, CCND1
46
Apoptosis and survival Apoptotic TNF-family pathways
Hide members
8.2CASP7, CASP8, CDKN1A, BCL2, TP53
47
Hide members
8.2CASP7, CASP8, CDKN1A, BCL2, TP53
48
Hide members
8.1CASP7, CASP8, CD44, BCL2, TP53
49
Hide members
7.8CCND1, CASP7, CASP8, CDKN1A, BCL2, TP53
507.8TP53, BCL2, CDKN1A, CASP8, CASP7, CCND1

Compounds for genes affiliated with Gastrointestinal Lymphoma

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 60Tocris Bioscience, 24HMDB
See all sources

Compounds related to Gastrointestinal Lymphoma according to GeneCards/GeneDecks:

(show top 50)    (show all 145)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.5CASP8
2tamoxifen45 50 29 1113.2CDKN1A, CCND1
3depsipeptide4510.1TP53, CCND1
4optimax459.5CDKN1A, IFI27, CCND1
5serine459.5NBN, CD44, CCND1
6sulindac sulfide459.3CCND1, CASP8, BCL2, TP53
7sulforaphane459.3CCND1, CASP8, CDKN1A, BCL2
8noxa459.3CASP8, CDKN1A, BCL2, TP53
9olomoucine45 1110.1CCND1, CASP8, CDKN1A, BCL2, TP53
10suberoylanilide hydroxamic acid459.0CCND1, CASP8, CDKN1A, BCL2, TP53
11eb 108945 6010.0CCND1, IFI27, CDKN1A, BCL2
122-methoxyestradiol45 60 2411.0CCND1, CASP8, CDKN1A, BCL2, TP53
13n-(4-hydroxyphenyl)retinamide459.0CCND1, CASP8, CDKN1A, BCL2, TP53
14arsenite45 2410.0TP53, BCL2, CDKN1A, CASP8, CCND1
15flavopiridol45 1110.0CCND1, CASP8, CDKN1A, BCL2, TP53
1610-hydroxycamptothecin459.0TP53, BCL2, CDKN1A
17gemcitabine45 50 1111.0CCND1, CASP8, CDKN1A, BCL2, TP53
18lactacystin459.0CCND1, CASP8, CDKN1A, BCL2, TP53
19paraffin459.0IFI27, CD44, CDKN1A, BCL2
20z-vad-fmk45 609.8TP53, BCL2, CASP8, CASP7
21mevastatin45 29 1110.8CASP7, CASP8, IFI27, CDKN1A
22curcumin458.7CCND1, CASP8, CDKN1A, BCL2, TP53
23etoposide45 50 60 1111.7CASP7, CASP8, CD44, NBN, BCL2
24troglitazone45 29 60 1111.7CCND1, CASP8, IFI27, CDKN1A, BCL2
25adriamycin458.7CCND1, CASP8, CD44, CDKN1A, BCL2, TP53
26thymidylate458.6CCND1, IFI27, CDKN1A, BCL2, TP53
27topotecan45 119.6TP53, BCL2, CASP8, CASP7
28cd 437458.6CASP7, CASP8, CDKN1A, BCL2, TP53
29dutp458.5CCND1, CASP7, CASP8, BCL2, TP53
30indole-3-carbinol458.5CCND1, CASP8, IFI27, CDKN1A, BCL2, TP53
31sulindac45 119.5CCND1, CASP8, IFI27, CDKN1A, BCL2, TP53
32roscovitine458.5CCND1, CASP8, IFI27, CDKN1A, BCL2, TP53
33docetaxel45 50 60 1111.4CASP7, CASP8, CDKN1A, BCL2, TP53
34retinoid458.4TP53, BCL2, CDKN1A, IFI27, CASP8, CCND1
35camptothecin45 60 1110.3CASP7, CASP8, CDKN1A, NBN, BCL2, TP53
36bortezomib45 119.2CCND1, CASP7, CASP8, CDKN1A, BCL2, TP53
37sp 60012545 609.2CCND1, CASP7, CASP8, CDKN1A, BCL2, TP53
38cytarabine45 50 1110.1CASP7, IFI27, CDKN1A, BCL2, TP53
39phosphatidylserine45 29 1110.1TP53, BCL2, CD44, CASP8, CASP7
40paclitaxel45 50 1110.1CCND1, CASP8, IFI27, CD44, CDKN1A, BCL2
415fluorouracil458.1CASP7, CASP8, CDKN1A, BCL2, TP53
42adpribose457.6CCND1, CASP7, CASP8, IFI27, CDKN1A, BCL2
43mg 13245 608.6CCND1, CASP7, CASP8, IFI27, CDKN1A, BCL2
44progesterone45 60 29 11 2411.4CCND1, CASP7, IFI27, CD44, CDKN1A, BCL2
45n acetylcysteine457.4CCND1, CASP7, CASP8, IFI27, CDKN1A, NBN
46vegf457.3CCND1, CASP7, IFI27, CD44, CDKN1A, BCL2
47ly294002457.3CCND1, CASP7, CASP8, IFI27, CD44, CDKN1A
48cisplatin45 50 60 1110.2CCND1, CASP7, CASP8, IFI27, CD44, CDKN1A
49retinoic acid45 248.2CCND1, CASP7, CASP8, IFI27, CD44, CDKN1A
50doxorubicin45 50 119.0TP53, CCND1, CASP7, CASP8, IFI27, CD44

GO Terms for genes affiliated with Gastrointestinal Lymphoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Gastrointestinal Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein kinase holoenzyme complexGO:0003079.8CDKN1A, CCND1
2replication forkGO:0056579.4NBN, TP53
3mitochondrial outer membraneGO:0057419.0BCL2, IFI27, CASP8
4nucleoplasmGO:0056548.2TP53, NBN, CDKN1A, CASP7, CCND1

Biological processes related to Gastrointestinal Lymphoma according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1response to organonitrogen compoundGO:01024310.1CDKN1A, CCND1
2response to corticosterone stimulusGO:05141210.1CDKN1A, CCND1
3response to iron ionGO:01003910.1BCL2, CCND1
4DNA damage response, signal transduction by p53 class mediatorGO:03033010.0NBN, TP53
5mitotic cell cycle arrestGO:07185010.0TP53, CDKN1A
6mitotic G1 DNA damage checkpointGO:03157110.0CCND1, TP53
7positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayGO:190074010.0BCL2, CASP8
8B cell lineage commitmentGO:00232610.0TP53, BCL2
9response to X-rayGO:0101659.9TP53, CCND1
10regulation of mitochondrial membrane permeabilityGO:0469029.9TP53, BCL2
11cellular response to ionizing radiationGO:0714799.9CDKN1A, TP53
12positive regulation of intrinsic apoptotic signaling pathwayGO:20012449.8BCL2, TP53
13positive regulation of reactive oxygen species metabolic processGO:20003799.8TP53, CDKN1A
14cell agingGO:0075699.8BCL2, TP53
15response to gamma radiationGO:0103329.7TP53, BCL2
16response to antibioticGO:0466779.7CASP8, TP53
17cell cycle arrestGO:0070509.7TP53, NBN, CDKN1A
18negative regulation of cell growthGO:0303089.6TP53, BCL2, CDKN1A
19T cell differentiation in thymusGO:0330779.5TP53, BCL2
20neuron apoptotic processGO:0514029.3TP53, BCL2
21response to DNA damage stimulusGO:0069749.3CCND1, CDKN1A, BCL2, TP53
22release of cytochrome c from mitochondriaGO:0018369.2CASP7, BCL2, TP53
23negative regulation of apoptotic processGO:0430669.2CD44, CDKN1A, BCL2, TP53
24heart developmentGO:0075079.1CASP7, CASP8, ADAP2
25apoptotic processGO:0069158.7BCL2, NBN, CASP8, CASP7
26intrinsic apoptotic signaling pathwayGO:0971938.5TP53, BCL2, CDKN1A, CASP8, CASP7

Molecular functions related to Gastrointestinal Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein phosphatase 2A bindingGO:0517219.6TP53, BCL2
2protease bindingGO:0020209.2TP53, BCL2, CASP8
3protein bindingGO:0055156.3CCND1, CASP7, CASP8, CD44, CDKN1A, NBN

Products for genes affiliated with Gastrointestinal Lymphoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gastrointestinal Lymphoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet