Gastrointestinal Lymphoma disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Gastrointestinal Lymphoma

MalaCards based summary: Gastrointestinal Lymphoma is related to b-cell lymphomas and intestinal disease. An important gene associated with Gastrointestinal Lymphoma is NBN (nibrin), and among its related pathways are Transcriptional activation of cell cycle inhibitor p21 and Validated targets of C-MYC transcriptional repression. The compounds optimax and sulindac sulfide have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and colon, and related mouse phenotypes are craniofacial and renal/urinary system.

Aliases & Classifications for Gastrointestinal Lymphoma

Sources:
⁹Disease Ontology, ¹¹DISEASES, ⁶¹UMLS, ³⁹NCIt
See all sources

Gastrointestinal Lymphoma, Aliases & Descriptions:

Name: Gastrointestinal Lymphoma ⁹ ¹¹ ⁶¹

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Gastrointestinal diseases, Immune diseases

External Ids:

Disease Ontology⁹ DOID:903

NCIt³⁹ C38162

UMLS⁶¹ C0740372

Related Diseases for Gastrointestinal Lymphoma

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
See all sources

Diseases related to Gastrointestinal Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 74)

id	Related Disease	Score	Top Affiliating Genes
1	b-cell lymphomas	28.2	TRG, CD44, CDKN1A, CASP8, BCL2, IFI27
2	intestinal disease	10.5	IGHV1-2
3	thoracic cancer	10.3	CDKN1A
4	esophageal squamous cell carcinoma	10.2	CCND1, IFI27
5	multiple myeloma	10.2	CD44, CCND1
6	bladder transitional cell carcinoma	10.2	IFI27, TP53
7	breast ductal carcinoma	10.1	CD44, TP53
8	cervical adenocarcinoma	10.1	IFI27, CDKN1A
9	follicular adenoma	10.1	CD44, IFI27
10	heavy chain disease	10.1
11	inflammatory bowel disease	10.1
12	ductal carcinoma in situ	10.1	CCND1, TP53
13	li-fraumeni syndrome	10.1	CDKN1A, TP53
14	papillary thyroid carcinoma	10.1	CD44, IFI27, CCND1
15	lymphoma, small cleaved-cell, diffuse	10.1	CCND1, BCL2
16	tongue squamous cell carcinoma	10.1	CCND1, CD44
17	mantle cell lymphoma	10.0	CCND1, BCL2
18	esophageal cancer	10.0	IFI27, CCND1, TP53
19	ataxia telangiectasia	10.0	NBN, TP53, CDKN1A
20	papilloma	10.0	CDKN1A, IFI27, TP53
21	hodgkin's lymphoma	10.0
22	amyloidosis	10.0
23	sarcoma	10.0
24	alpha heavy-chain disease	10.0
25	barrett's esophagus	10.0	CCND1, TP53
26	thyroid cancer, anaplastic	10.0	CDKN1A, CASP8, TP53
27	kidney cancer	9.9	IFI27, CASP8, CASP7, CD44
28	bladder carcinoma	9.9	CD44, CDKN1A, TP53
29	malt lymphoma	9.9	CCND1, BCL2
30	endometrial carcinoma	9.9	BCL2, TP53
31	rheumatoid arthritis	9.9	TRG, CD44, CASP7, CASP8
32	squamous cell carcinoma of the head and neck	9.9	TP53, CCND1, CDKN1A
33	thyroid hurthle cell carcinoma	9.9	TP53, CCND1, CDKN1A
34	gastric adenocarcinoma	9.9	BCL2, CASP8, CD44
35	bladder carcinoma in situ	9.9	CCND1, TP53
36	basal cell carcinoma	9.9	CD44, BCL2, TP53
37	follicular lymphoma	9.9	CASP8, BCL2, CCND1
38	acute lymphoblastic leukemia	9.8	NBN, BCL2, CASP8, TRG
39	transitional cell carcinoma	9.8	TP53, IFI27, CDKN1A, CD44
40	chronic lymphocytic leukemia	9.8	CCND1, BCL2, CASP8
41	acute promyelocytic leukemia	9.8	BCL2, CASP8, CDKN1A
42	vascular disease	9.8	TP53, BCL2, CASP8
43	colon adenocarcinoma	9.8	CDKN1A, CASP8, BCL2
44	glioblastoma multiforme	9.8	TP53, CASP8, CDKN1A, CD44
45	brain cancer	9.8	TP53, CASP8, CDKN1A, CD44
46	oral cancer	9.8	TP53, CCND1, IFI27, CDKN1A
47	burkitt's lymphoma	9.8	CD44, CASP8, BCL2, IFI27
48	myeloid leukemia	9.7	CDKN1A, CASP8, BCL2
49	laryngeal benign neoplasm	9.7	TP53, CCND1, IFI27, BCL2
50	lung small cell carcinoma	9.7	TP53, BCL2, CASP8, CD44

Graphical network of the top 20 diseases related to Gastrointestinal Lymphoma:

Symptoms for Gastrointestinal Lymphoma

Drugs & Therapeutics for Gastrointestinal Lymphoma

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials
See all sources

Drug clinical trials:

Search ClinicalTrials for Gastrointestinal Lymphoma

Search NIH Clinical Center for Gastrointestinal Lymphoma

Genetic Tests for Gastrointestinal Lymphoma

Anatomical Context for Gastrointestinal Lymphoma

Sources:
³²MalaCards
See all sources

MalaCards organs/tissues related to Gastrointestinal Lymphoma:

³²

T cells, B cells, Colon

Animal Models for Gastrointestinal Lymphoma or affiliated genes

Sources:
³⁶MGI
See all sources

MGI Mouse Phenotypes related to Gastrointestinal Lymphoma:

³⁶ (show all 18)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	craniofacial phenotype	MP:0005382	8.8	NBN, TP53, CCND1, BCL2, CDKN1A
2	renal/urinary system phenotype	MP:0005367	8.8	TP53, BCL2, CASP8, CDKN1A, CD44
3	tumorigenesis	MP:0002006	8.7	NBN, TP53, CCND1, BCL2, CDKN1A, CD44
4	respiratory system phenotype	MP:0005388	8.7	TP53, CCND1, BCL2, CASP8, CDKN1A, CD44
5	reproductive system phenotype	MP:0005389	8.6	NBN, TP53, CCND1, BCL2, CDKN1A, CD44
6	behavior/neurological phenotype	MP:0005386	8.5	CD44, CDKN1A, BCL2, CCND1, TP53, NBN
7	endocrine/exocrine gland phenotype	MP:0005379	8.5	NBN, TP53, CCND1, BCL2, CASP8, CDKN1A
8	muscle phenotype	MP:0005369	8.5	TP53, BCL2, CASP8, CDKN1A, CD44
9	digestive/alimentary phenotype	MP:0005381	8.4	TP53, CCND1, BCL2, CDKN1A, CD44, TRG
10	integument phenotype	MP:0010771	8.2	TP53, CCND1, BCL2, CASP8, CDKN1A, CD44
11	vision/eye phenotype	MP:0005391	8.1	TP53, CCND1, BCL2, CASP7, CDKN1A, CD44
12	growth/size/body phenotype	MP:0005378	8.1	NBN, TP53, CCND1, BCL2, CASP8, CDKN1A
13	cardiovascular system phenotype	MP:0005385	7.8	TP53, CCND1, BCL2, CASP8, CASP7, CDKN1A
14	nervous system phenotype	MP:0003631	7.6	NBN, TP53, CCND1, BCL2, CASP8, CASP7
15	mortality/aging	MP:0010768	7.5	NBN, TP53, CCND1, BCL2, CASP8, CASP7
16	hematopoietic system phenotype	MP:0005397	7.2	TRG, NBN, TP53, CCND1, BCL2, CASP8
17	immune system phenotype	MP:0005387	7.1	NBN, TP53, CCND1, BCL2, CASP8, CASP7
18	cellular phenotype	MP:0005384	7.1	NBN, TP53, CCND1, BCL2, CASP8, CASP7

Publications for Gastrointestinal Lymphoma

Sources:
⁵¹PubMed
See all sources

Articles related to Gastrointestinal Lymphoma:

(show top 50) (show all 121)

id	Title	Authors	Year
1	Primary extranodal gastrointestinal lymphoma: a single center experience from southern Iran - report of changing epidemiology. (25204482)	Geramizadeh B.... Keshtkar Jahromi M.	2014
2	Clinicopathological characteristics and prognostic factors of primary gastrointestinal lymphoma: a 22-year experience from South China. (24966993)	Li M.... Zhong B.	2014
3	Endoscopic appearance of AIDS-related gastrointestinal lymphoma with c-MYC rearrangements: case report and literature review. (23922484)	Tanaka S.... Uemura N.	2013
4	Primary gastrointestinal lymphoma in an Egyptian district: a study using a population-based cancer registry. (23719408)	Saber M.M.... Farag S.A.	2013
5	Gastrointestinal lymphoma: recent advances in diagnosis and treatment. (23635497)	Nakamura S.... Matsumoto T.	2013
6	Imaging of primary gastrointestinal lymphoma. (24332207)	Chang S.T.... Menias C.O.	2013
7	Primary gastrointestinal lymphoma. (23626617)	Aledavood A.... Mohtashami S.	2012
8	Primary gastrointestinal lymphoma. (21390139)	Ghimire P.... Zhu L.	2011
9	Primary pediatric gastrointestinal lymphoma. (22174497)	Bandyopadhyay R.... Biswas P.K.	2011
10	Double-balloon endoscopy depicts diminutive small bowel lesions in gastrointestinal lymphoma. (19241169)	Matsumoto T.... Iida M.	2010
11	The association of HTLV-1 infection, persistent intestinal infection with Strongyloides stercoralis and gastrointestinal lymphoma. (21686837)	Choksi M.... Ramakrishna B.S.	2009
12	Efficacy of combination chemotherapy for treatment of gastrointestinal lymphoma in dogs. (19192147)	Rassnick K.M.... Bailey D.B.	2009
13	Imaging of gastrointestinal lymphoma. (18619382)	Gollub M.J.	2008
14	What to do when you suspect gastrointestinal lymphoma: a pathologist's perspective. (17336592)	Gurbuxani S.... Anastasi J.	2007
15	Primary gastrointestinal lymphoma--a clinicopathologic study. (17883049)	Shukla K.... Palanki S.	2007
16	Absence of CASP7 and CASP8 mutation in gastrointestinal lymphomas. (17532763)	Yoo N.J.... Lee S.H.	2007
17	Gastrointestinal lymphoma in Thailand: a clinicopathologic analysis of 120 cases at Siriraj Hospital according to WHO classification. (15916100)	Sukpanichnant S.... Chinswangwatanakul V.	2004
18	AIDS-associated gastrointestinal lymphoma: is there a role for surgery in the standard of care? (14600583)	Fasan M.L.... Cargnel A.	2003
19	The role of cytomegalovirus in inflammatory bowel disease and gastrointestinal lymphoma. (12105877)	Adani G.L.... Avital I.	2002
20	p53 protein expression in gastrointestinal lymphomas. (8978599)	Hazar B.... Tuncer I.	1997
21	Prognostic factors for primary gastrointestinal lymphoma. (7622145)	Liang R.... Ho F.C.	1995
22	Detection of clonal T-cell populations in gastrointestinal lymphomas by analysis of cRNA conformational polymorphisms of rearranged T-cell-receptor-gamma genes. (8199020)	Koch O.M.... Danenberg P.V.	1994
23	Predominantly gastrointestinal symptoms and signs in 11 consecutive AIDS patients with gastrointestinal lymphoma: a multicenter, multiyear study including 763 HIV-seropositive patients. (8147357)	Cappell M.S.... Botros N.	1994
24	Immunoglobulin specificity of low grade B cell gastrointestinal lymphoma of mucosa-associated lymphoid tissue (MALT) type. (8424461)	Hussell T.... Spencer J.	1993
25	Lymphocyte homing receptor (CD44) expression is associated with poor prognosis in gastrointestinal lymphoma. (8347502)	Joensuu H.... Jalkanen S.	1993
26	Clinical oncology: case presentations from oncology centres. Intensive treatment of poor prognosis gastrointestinal lymphoma. (1382496)	Pettengell R.... Crowther D.	1992
27	Primary gastrointestinal lymphoma: a clinicopathological study of 58 cases. (1398301)	Cirillo M.... Silingardi V.	1992
28	Primary gastrointestinal lymphoma in childhood (up to 18 years of age). A morphological, immunohistochemical and clinical study. (2324163)	Takahashi H.... Hansmann M.L.	1990
29	Outcome analysis of localized gastrointestinal lymphoma treated with surgery and postoperative irradiation. (2262357)	Gospodarowicz M.K.... Bush R.S.	1990
30	Gastrointestinal lymphoma: sonographic findings in 54 patients. (2119110)	Goerg C.... Goerg K.	1990
31	Genomic analysis of T-cell receptor and immunoglobulin antigen receptor genes and breakpoint cluster regions in gastrointestinal lymphomas. (2249841)	Hey M.M.... MA1ller-Hermelink H.K.	1990
32	Gastrointestinal lymphoma in 20 dogs. A retrospective study. (2715959)	Couto C.G.... Rojko J.	1989
33	Primary gastrointestinal lymphoma. (3285479)	Haber D.A.... Mayer R.J.	1988
34	Gastrointestinal lymphoma in Chinese: a retrospective analysis. (3297967)	Liang R.... Ho F.C.	1987
35	Gastrointestinal lymphoma and sarcoma. A case for aggressive search and destroy. (3592804)	Adkins R.B.... Sawyers J.L.	1987
36	Primary gastrointestinal lymphoma. (3112669)	Ampil F.L.	1987
37	Primary gastrointestinal lymphoma complicated by common bile duct obstruction: report of two cases. (3526871)	Radhakrishnan S.... Al Ruwaih A.	1986
38	Primary gastrointestinal lymphoma. A clinicopathologic study of 102 patients. (3887261)	Aozasa K.... Nosaka J.	1985
39	Primary gastrointestinal lymphoma. (4023780)	Fitch D.D.... Wilson J.A.	1985
40	Gastrointestinal lymphoma with total involvement of the gut--report of one case. (6549075)	Aspestrand F.... Melsom M.	1984
41	Primary gastrointestinal lymphoma: a review of 21 cases. (6374297)	Kaufman Z.... Dinbar A.	1984
42	Primary gastrointestinal lymphoma in Jordan. (6670122)	Dajani Y.F.... al-Jitawi S.	1983
43	Computed tomography of gastrointestinal lymphoma. (6603767)	Megibow A.J.... Bosniak M.A.	1983
44	Curability of gastrointestinal lymphoma with combined surgery and radiation. (6841173)	Gospodarowicz M.K.... Chua T.	1983
45	Gastrointestinal lymphoma. (6656946)	Philben V.J.... Armitage J.O.	1983
46	On primary gastrointestinal lymphoma in Iraq (experience with 47 patients). (4571783)	l-Bahrani Z.R.	1972
47	Primary gastrointestinal lymphoma. A clinicopathologic study of fifty-seven cases. (4554148)	Kahn L.B.... Kaschula R.O.	1972
48	Gastrointestinal lymphoma in childhood. (4920414)	Berry C.L.... Keeling J.W.	1970
49	GASTROINTESTINAL LYMPHOMA. (14136947)	Johnson L.A.	1964
50	Roentgen therapy of primary gastrointestinal lymphoma. (13881055)	COOK J.C.... CORBETT D.P.	1962

Genes related to Gastrointestinal Lymphoma

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals
See all sources

Genes related to Gastrointestinal Lymphoma:

(show all 12)

- Elite gene

id	Symbol	Description	Score	Implication
1	NBN	nibrin	20.78	GeneCards inferred via : Publications (show sections)
2	CD44	CD44 molecule (Indian blood group)	19.11	GeneCards inferred via : Publications (show sections)
3	CASP8	caspase 8, apoptosis-related cysteine peptidase	17.44	GeneCards inferred via : Publications (show sections)
4	CCND1	cyclin D1	15.78	GeneCards inferred via : Publications (show sections)
5	CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	14.11	GeneCards inferred via : Publications (show sections)
6	BCL2	B-cell CLL/lymphoma 2	12.44	GeneCards inferred via : Publications (show sections)
7	TP53	tumor protein p53	10.78	GeneCards inferred via : Publications (show sections)
8	IGHV1-2	immunoglobulin heavy variable 1-2	9.11	GeneCards inferred via : Disorders (show sections)
9	TRG	T cell receptor gamma locus	7.44	GeneCards inferred via : Publications (show sections)
10	ADAP2	ArfGAP with dual PH domains 2	5.78	GeneCards inferred via : Disorders (show sections)
11	CASP7	caspase 7, apoptosis-related cysteine peptidase	4.11	GeneCards inferred via : Publications (show sections)
12	IFI27	interferon, alpha-inducible protein 27	2.44	GeneCards inferred via : Publications (show sections)

Products for genes related to Gastrointestinal Lymphoma disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	10	-	11	10
2	Novus Biologicals	10	9	11	-

Variations for Gastrointestinal Lymphoma

Expression for genes affiliated with Gastrointestinal Lymphoma

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Gastrointestinal Lymphoma

Search GEO for disease gene expression data for Gastrointestinal Lymphoma.

Pathways for genes affiliated with Gastrointestinal Lymphoma

Sources:
⁴⁹PathCards, ⁵⁴Reactome, ³⁷NCBI BioSystems Database, ⁵²QIAGEN, ³⁰KEGG, ⁵⁹Thomson Reuters, ¹³EMD Millipore, ⁵⁰PharmGKB, ⁵Cell Signaling Technology, ⁶⁰Tocris Bioscience, ⁵³R&D Systems, ⁵⁵SinoBiological
See all sources

Pathways related to Gastrointestinal Lymphoma according to GeneCards/GeneDecks:

(show top 50) (show all 74)

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Transcriptional activation of cell cycle inhibitor p21⁵⁴ Show member pathways Transcriptional activation of p53 responsive genes⁵⁴	9.7	TP53, CDKN1A
2	Validated targets of C-MYC transcriptional repression³⁷	9.4	CDKN1A, BCL2, CCND1
3	C-MYB transcription factor network³⁷	9.4	CDKN1A, BCL2, CCND1
4	miRNAs involved in DDR³⁷	9.4	TP53, CCND1, CDKN1A
5	Cyclins and Cell Cycle Regulation⁵² Show member pathways Cell Cycle Control by BTG Proteins⁵² Phosphorylation of proteins involved in G1/S transition by active Cyclin E-Cdk2 complexes⁵⁴ G1-S Phase Transition⁵² G1 Phase⁵⁴ Cyclin D associated events in G1⁵⁴	9.4	TP53, CCND1, CDKN1A
6	GADD45 Pathway⁵²	9.4	TP53, CCND1, CDKN1A
7	Cell cycle³⁰ Show member pathways Cell cycle³⁷	9.4	CDKN1A, CCND1, TP53
8	RB in Cancer³⁷	9.4	TP53, CCND1, CDKN1A
9	Chronic myeloid leukemia³⁰ Show member pathways Pancreatic cancer³⁰	9.4	TP53, CCND1, CDKN1A
10	Glioblastoma Multiforme⁵²	9.4	CDKN1A, CCND1, TP53
11	Development IGF 1 receptor signaling⁵⁹ Show member pathways Development IGF RI signaling¹³ Immune response IL 4 signaling pathway⁵⁹ Signal transduction AKT signaling⁵⁹	9.4	CDKN1A, CCND1, TP53
12	ErbB signaling pathway³⁰ Show member pathways ErbB receptor signaling network³⁷ ErbB signaling pathway³⁷ EGFR Inhibitor Pathway, Pharmacodynamics⁵⁰	9.4	TP53, CCND1, CDKN1A
13	Small cell lung cancer³⁰	9.4	BCL2, CCND1, TP53
14	TP53 network³⁷ Show member pathways Activation, translocation and oligomerization of BAX⁵⁴	9.3	CDKN1A, BCL2, TP53
15	Transcription P53 signaling pathway⁵⁹	9.3	CDKN1A, BCL2, TP53
16	Direct p53 effectors³⁷	9.3	TP53, BCL2, CDKN1A
17	Cell Cycle / Checkpoint Control⁵ Show member pathways DNA Damage⁵	9.1	NBN, TP53, CCND1, CDKN1A
18	DNA damage ATM ATR regulation of G1 S checkpoint⁵⁹	9.1	CDKN1A, CCND1, TP53, NBN
19	Proteoglycans in cancer³⁰	9.1	TP53, CCND1, CDKN1A, CD44
20	TGF-beta Receptor Signaling Pathway³⁷	9.1	CD44, CDKN1A, CCND1, TP53
21	Viral carcinogenesis³⁰	9.1	TP53, CCND1, CASP8, CDKN1A
22	Prostate cancer³⁰ Show member pathways Prostate Cancer³⁷ Integrated Cancer pathway³⁷ Steroid Biosynthesis³⁷	9.1	TP53, CCND1, BCL2, CASP8
23	Integrated Breast Cancer Pathway³⁷	9.1	TP53, CCND1, BCL2, CASP8
24	Senescence and Autophagy³⁷	9.1	CD44, CDKN1A, BCL2, TP53
25	Epstein-Barr virus infection³⁰	9.1	CD44, CDKN1A, BCL2, TP53
26	PI3K-Akt signaling pathway³⁰	9.0	CDKN1A, BCL2, CCND1, TP53
27	Glioma³⁰ Show member pathways Melanoma³⁰ Non-small cell lung cancer³⁰ Bladder cancer³⁰ Prostate cancer³⁰ Signaling Pathways in Glioblastoma³⁷	9.0	TP53, CCND1, BCL2, CDKN1A
28	Endometrial cancer³⁰ Show member pathways Colorectal cancer³⁰ Signal transduction PTEN pathway⁵⁹ Acute myeloid leukemia³⁰	9.0	TP53, CCND1, BCL2, CDKN1A
29	Ceramide Pathway⁵² Show member pathways TNF-Induced Apoptosis Implicating Sphingolipids⁵²	9.0	CASP7, CASP8, BCL2
30	Apoptosis and survival Caspase cascade⁵⁹ Show member pathways Breakdown of the nuclear lamina⁵⁴ FAS pathway and Stress induction of HSP regulation³⁷ Apoptosis and survival FAS signaling cascades⁵⁹ Caspase cascade in apoptosis³⁷ Stimulation of the cell death response by PAK-2p34⁵⁴	9.0	BCL2, CASP8, CASP7
31	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways⁵⁴ Show member pathways The IPAF inflammasome⁵⁴ NOD pathway³⁷ Inflammasomes⁵⁴ Influenza A virus infection³⁷ NOD1/2 Signaling Pathway⁵⁴ The AIM2 inflammasome⁵⁴ The NLRP1 inflammasome⁵⁴ NOD-like receptor signaling pathway³⁰	9.0	BCL2, CASP8, CASP7
32	Presenilin-Mediated Signaling⁵²	9.0	BCL2, CASP8, CASP7
33	p53 signaling pathway³⁰ Show member pathways DNA damage response³⁷	8.8	CDKN1A, CASP8, CCND1, TP53, NBN
34	MicroRNAs in cancer³⁰	8.7	TP53, CCND1, BCL2, CDKN1A, CD44
35	Wnt Signaling Pathway³⁷ Show member pathways DNA damage response (only ATM dependent)³⁷ Wnt Signaling Pathway and Pluripotency³⁷	8.7	TP53, CCND1, BCL2, CDKN1A, CD44
36	Toll-like receptor signaling pathway³⁰ Show member pathways Chagas disease (American trypanosomiasis)³⁰ Toll-like receptor signaling pathway³⁷ Regulation of toll-like receptor signaling pathway³⁷ Hepatitis B³⁰	8.7	TP53, CCND1, BCL2, CASP8, CDKN1A
37	Pathways in cancer³⁰	8.7	TP53, CCND1, BCL2, CASP8, CDKN1A
38	Apoptosis⁵⁴ Show member pathways 14-3-3 Induced Apoptosis⁵² Apoptosis³⁰	8.6	CASP7, CASP8, BCL2, TP53
39	Activation of BH3-only proteins⁵⁴ Show member pathways Intrinsic Pathway for Apoptosis⁵⁴ Activation of BMF and translocation to mitochondria⁵⁴ Activation, myristolyation of BID and translocation to mitochondria⁵⁴ Release of apoptotic factors from the mitochondria⁵⁴ Activation of BIM and translocation to mitochondria⁵⁴ Activation of NOXA and translocation to mitochondria⁵⁴ Apoptotic factor-mediated response⁵⁴ Activation of BAD and translocation to mitochondria⁵⁴ Activation of PUMA and translocation to mitochondria⁵⁴	8.6	TP53, BCL2, CASP8, CASP7
40	Apoptosis Pathway⁶⁰ Show member pathways Akt Pathway⁶⁰ NF-kappaB Pathway⁶⁰	8.6	TP53, BCL2, CASP8, CASP7
41	TWEAK Pathway⁵² Show member pathways Apoptotic Pathways Triggered By HIV1⁵² Apoptosis and survival TNFR1 signaling pathway⁵⁹ TRAIL Pathway⁵² Fas Signaling⁵² GITR Pathway⁵² TNFR1 Pathway⁵² DR3 Signaling⁵² Apoptosis through Death Receptors⁵² TWEAK Signaling Pathway³⁷ TNF Signaling⁵² Apoptosis Modulation by HSP70³⁷ Viral RNP Complexes in the Host Cell Nucleus⁵⁴ HIV-1 Nef- Negative effector of Fas and TNF-alpha³⁷	8.6	CASP7, CASP8, BCL2, TP53
42	Apoptosis⁵⁴ Show member pathways Apoptosis Modulation and Signaling³⁷ Apoptosis³⁷	8.6	TP53, BCL2, CASP8, CASP7
43	Selected targets of p53¹³	8.5	TP53, BCL2, CASP7, CDKN1A
44	Apoptotic Pathways in Synovial Fibroblasts⁵² Show member pathways Actin-Based Motility by Rho Family GTPases⁵² PPAR Pathway⁵² Cellular Apoptosis Pathway⁵² Rac1 Pathway⁵² Glioma Invasiveness⁵² eIF2 Pathway⁵² ERK5 Signaling⁵² p53 Mediated Apoptosis⁵² Mitochondrial Apoptosis⁵² Rap1 Pathway⁵² Telomerase Components in Cell Signaling⁵² Nuclear Receptor Activation by Vitamin-A⁵² DHA Signaling⁵²	8.3	TP53, BCL2, CASP8, CASP7, CD44
45	PEDF Induced Signaling⁵² Show member pathways all-trans-Retinoic Acid Signaling in Brain⁵² Cytokine-cytokine receptor interaction³⁰ NFAT Signaling and Lymphocyte Interactions⁵² STAT3 Pathway⁵² RAR-Gamma-RXR-Alpha Degradation⁵² PGC1Alpha Pathway⁵² Glucocorticoid Receptor Signaling⁵² IL-6 Pathway⁵² Endothelin-1 Signaling Pathway⁵² MIF Regulation of Innate Immune Cells⁵² MIF Mediated Glucocorticoid Regulation⁵²	8.2	TP53, BCL2, CASP8, CASP7, CDKN1A
46	Apoptosis Signaling Pathways⁵³ Show member pathways Apoptosis and survival Apoptotic TNF family pathways⁵⁹	8.2	TP53, BCL2, CASP8, CASP7, CDKN1A
47	p53 Signaling⁵² Show member pathways p53 Pathway⁵⁵	7.9	CDKN1A, CASP7, CASP8, BCL2, CCND1, TP53
48	ERK Signaling⁵² Show member pathways ILK Signaling⁵² Molecular Mechanisms of Cancer⁵² Rho Family GTPases⁵² MAPK Signaling⁵²	7.9	TP53, CCND1, BCL2, CASP8, CASP7, CDKN1A
49	Integrated Pancreatic Cancer Pathway³⁷	7.9	TP53, CCND1, BCL2, CASP8, CASP7, CDKN1A
50	CDK-mediated phosphorylation and removal of Cdc6⁵⁴ Show member pathways APC/C-mediated degradation of cell cycle proteins⁵⁴ Antigen processing-Cross presentation⁵⁴ Autodegradation of the E3 ubiquitin ligase COP1⁵⁴ Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)⁵⁴ SCF-beta-TrCP mediated degradation of Emi1⁵⁴ Regulation of Apoptosis⁵⁴ Regulation of PAK-2p34 activity by PS-GAP/RHG10⁵⁴ Destabilization of mRNA by KSRP⁵⁴ DNA Replication Pre-Initiation⁵⁴ Cross-presentation of particulate exogenous antigens (phagosomes)⁵⁴ Switching of origins to a post-replicative state⁵⁴ Proteasome Degradation³⁷ Regulation of mRNA Stability by Proteins that Bind AU-rich Elements⁵⁴ M/G1 Transition⁵⁴ Conversion from APC/C-Cdc20 to APC/C-Cdh1 in late anaphase⁵⁴ CDC6 association with the ORC-origin complex⁵⁴ S Phase⁵⁴ Degradation of beta-catenin by the destruction complex⁵⁴ Immune response Antigen presentation by MHC class I⁵⁹ Phosphorylation of the APC/C⁵⁴ Regulation of mitotic cell cycle⁵⁴ Cyclin A-Cdk2-associated events at S phase entry⁵⁴ Regulation of APC/C activators between G1/S and early anaphase⁵⁴ APC/C-Cdc20 mediated degradation of mitotic proteins⁵⁴ Proteasome³⁰ Association of licensing factors with the pre-replicative complex⁵⁴ ER-Phagosome pathway⁵⁴ CDT1 association with the CDC6-ORC-origin complex⁵⁴ Cell Cycle Checkpoints⁵⁴ Cyclin E associated events during G1/S transition⁵⁴ Beta-catenin phosphorylation cascade⁵⁴ Parkinson's Disease Pathway⁵² APC/C-Cdh1 mediated degradation of Cdc20 and other APC/C-Cdh1 targeted proteins in late mitosis/early G1⁵⁴ APC/C-Cdc20 mediated degradation of Securin⁵⁴ Activation of APC/C and APC/C-Cdc20 mediated degradation of mitotic proteins⁵⁴ Activation of NF-kappaB in B Cells⁵⁴ Vpu mediated degradation of CD4⁵⁴ Regulation of activated PAK-2p34 by proteasome mediated degradation⁵⁴ p53-Independent G1/S DNA damage checkpoint⁵⁴ Regulation of ornithine decarboxylase (ODC)⁵⁴ Stabilization of mRNA by HuR⁵⁴ WNT5A-dependent internalization of FZD4⁵⁴ Destabilization of mRNA by Tristetraprolin (TTP)⁵⁴ SCF(Skp2)-mediated degradation of p27/p21⁵⁴ Regulation of DNA replication⁵⁴ Role of DCC in regulating apoptosis⁵⁴ Ubiquitin-dependent degradation of Cyclin D⁵⁴ Ubiquitin Mediated Degradation of Phosphorylated Cdc25A⁵⁴ p53-Dependent G1/S DNA damage checkpoint⁵⁴ p53-Dependent G1 DNA Damage Response⁵⁴ Apoptosis⁵⁴ DNA Replication⁵⁴ Vif-mediated degradation of APOBEC3G⁵⁴ Destabilization of mRNA by AUF1 (hnRNP D0)⁵⁴ p53-Independent DNA Damage Response⁵⁴ Cross-presentation of soluble exogenous antigens (endosomes)⁵⁴ Removal of licensing factors from origins⁵⁴ Endosomal/Vacuolar pathway⁵⁴ Stabilization of p53⁵⁴ Assembly of the pre-replicative complex⁵⁴ Ubiquitin-dependent degradation of Cyclin D1⁵⁴ PCP/CE pathway⁵⁴ G1/S DNA Damage Checkpoints⁵⁴ Orc1 removal from chromatin⁵⁴ Asymmetric localization of PCP proteins⁵⁴ Autodegradation of Cdh1 by Cdh1-APC/C⁵⁴ Establishment of Sister Chromatid Cohesion⁵⁴ WNT5A-dependent internalization of FZD2, FZD5 and ROR2⁵⁴ Synthesis of DNA⁵⁴	7.9	TP53, CCND1, BCL2, CASP8, CASP7, CDKN1A

Compounds for genes affiliated with Gastrointestinal Lymphoma

Sources:
⁴⁴Novoseek, ¹²DrugBank, ⁶⁰Tocris Bioscience, ²⁵HMDB, ²⁹IUPHAR, ⁵⁰PharmGKB
See all sources

Compounds related to Gastrointestinal Lymphoma according to GeneCards/GeneDecks:

(show top 50) (show all 160)

id	Compound	Score	Top Affiliating Genes
1	optimax⁴⁴	9.6	CCND1, IFI27, CDKN1A
2	sulindac sulfide⁴⁴	9.4	BCL2, CCND1, TP53, CASP8
3	noxa⁴⁴	9.3	TP53, BCL2, CASP8, CDKN1A
4	olomoucine⁴⁴ ¹²	10.1	CCND1, CASP8, CDKN1A, TP53, BCL2
5	sulforaphane⁴⁴	9.1	BCL2, CDKN1A, CCND1, CASP8
6	eb 1089⁴⁴ ⁶⁰	10.1	CDKN1A, BCL2, IFI27, CCND1
7	depsipeptide⁴⁴	9.1	TP53, CCND1, BCL2, CASP8, CDKN1A
8	suberoylanilide hydroxamic acid⁴⁴	9.1	CASP8, BCL2, CCND1, CDKN1A, TP53
9	2-methoxyestradiol⁴⁴ ⁶⁰ ²⁵	11.1	TP53, CCND1, CASP8, CDKN1A, BCL2
10	n-(4-hydroxyphenyl)retinamide⁴⁴	9.1	CDKN1A, CASP8, BCL2, TP53, CCND1
11	flavopiridol⁴⁴ ¹²	10.1	CCND1, CDKN1A, CASP8, BCL2, TP53
12	topotecan⁴⁴ ¹²	10.1	CASP8, CASP7
13	lactacystin⁴⁴	9.0	CCND1, CASP8, CDKN1A, BCL2, TP53
14	z-vad-fmk⁴⁴ ⁶⁰	9.9	CASP7, CASP8, BCL2, TP53
15	egcg⁴⁴	8.9	CCND1, CDKN1A, TP53, CASP8, BCL2
16	mevastatin⁴⁴ ²⁹ ¹²	10.8	CASP8, CASP7, CDKN1A, IFI27
17	adriamycin⁴⁴	8.8	BCL2, CCND1, CASP8, TP53, CD44, CDKN1A
18	troglitazone⁴⁴ ²⁹ ⁶⁰ ¹²	11.8	CCND1, IFI27, BCL2, CASP8, CDKN1A
19	thymidylate⁴⁴	8.8	BCL2, CDKN1A, TP53, IFI27, CCND1
20	indole-3-carbinol⁴⁴	8.6	TP53, IFI27, BCL2, CCND1, CASP8, CDKN1A
21	sulindac⁴⁴ ¹²	9.6	CASP8, CDKN1A, TP53, CCND1, IFI27, BCL2
22	dutp⁴⁴	8.6	CASP8, CASP7, BCL2, CCND1, TP53
23	roscovitine⁴⁴	8.6	CDKN1A, TP53, CASP8, BCL2, IFI27, CCND1
24	cd 437⁴⁴	8.6	CDKN1A, CASP7, CASP8, BCL2, TP53
25	curcumin⁴⁴	8.6	CDKN1A, CASP8, BCL2, TP53, CCND1
26	retinoid⁴⁴	8.5	TP53, CASP8, BCL2, IFI27, CCND1, CDKN1A
27	docetaxel⁴⁴ ⁵⁰ ⁶⁰ ¹²	11.4	CASP7, TP53, CASP8, BCL2, CDKN1A
28	camptothecin⁴⁴ ⁶⁰ ¹²	10.3	CDKN1A, BCL2, CASP7, CASP8, TP53, NBN
29	bortezomib⁴⁴ ⁵⁰ ¹²	10.3	CDKN1A, CASP7, CASP8, BCL2, CCND1, TP53
30	gemcitabine⁴⁴ ⁵⁰ ¹²	10.3	CDKN1A, BCL2, CCND1, TP53, CASP7, CASP8
31	sp 600125⁴⁴ ⁶⁰	9.3	TP53, CDKN1A, CCND1, CASP7, CASP8, BCL2
32	paraffin⁴⁴	8.3	CD44, CDKN1A, BCL2, IFI27, CCND1, TP53
33	phosphatidylserine⁴⁴ ²⁹ ¹²	10.3	TP53, BCL2, CASP7, CASP8, CD44
34	arsenite⁴⁴ ²⁵	9.3	CASP7, BCL2, TP53, CCND1, CDKN1A, CASP8
35	cytarabine⁴⁴ ⁵⁰ ¹²	10.3	IFI27, TP53, CASP7, CDKN1A, BCL2
36	etoposide⁴⁴ ⁵⁰ ⁶⁰ ¹²	11.1	CASP7, BCL2, NBN, TP53, CD44, CDKN1A
37	cycloheximide⁴⁴	7.9	CCND1, BCL2, CASP8, CASP7, CDKN1A, CD44
38	adpribose⁴⁴	7.8	CASP7, IFI27, TP53, CDKN1A, CCND1, BCL2
39	resveratrol⁴⁴ ⁶⁰ ²⁵ ¹²	10.8	CASP8, CASP7, CDKN1A, BCL2, TP53, CCND1
40	mg 132⁴⁴ ⁶⁰	8.8	CCND1, IFI27, BCL2, CASP8, CDKN1A, CASP7
41	tamoxifen⁴⁴ ⁵⁰ ²⁹ ¹²	10.8	CCND1, IFI27, BCL2, CASP7, CDKN1A, CD44
42	progesterone⁴⁴ ²⁹ ⁶⁰ ²⁵ ¹²	11.7	CDKN1A, CASP7, TP53, CCND1, IFI27, BCL2
43	n acetylcysteine⁴⁴	7.6	BCL2, CASP8, CASP7, CDKN1A, IFI27, TP53
44	butyrate⁴⁴	7.5	CD44, CDKN1A, CASP7, CASP8, IFI27, TP53
45	paclitaxel⁴⁴ ⁵⁰ ¹²	9.5	CASP8, CD44, BCL2, IFI27, CCND1, TP53
46	ly294002⁴⁴	7.5	CD44, CDKN1A, CASP7, BCL2, IFI27, CCND1
47	cisplatin⁴⁴ ⁵⁰ ⁶⁰ ¹²	10.5	TP53, CCND1, IFI27, BCL2, CASP8, CASP7
48	vegf⁴⁴	7.5	BCL2, CASP7, CDKN1A, TP53, CCND1, CD44
49	retinoic acid⁴⁴ ²⁵	8.4	CASP8, CASP7, TP53, BCL2, IFI27, CDKN1A
50	doxorubicin⁴⁴ ⁵⁰ ¹²	9.3	CDKN1A, TP53, CCND1, BCL2, CASP8, CASP7

GO Terms for genes affiliated with Gastrointestinal Lymphoma

Sources:
¹⁷Gene Ontology
See all sources

Cellular components related to Gastrointestinal Lymphoma according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cyclin-dependent protein kinase holoenzyme complex	GO:000307	9.9	CDKN1A, CCND1
2	replication fork	GO:005657	9.7	NBN, TP53
3	mitochondrial outer membrane	GO:005741	9.3	CASP8, BCL2, IFI27
4	nucleolus	GO:005730	8.8	CDKN1A, CASP8, CCND1, TP53, NBN
5	nucleoplasm	GO:005654	8.3	NBN, TP53, CCND1, CASP7, CDKN1A
6	cytosol	GO:005829	7.6	TP53, CCND1, BCL2, CASP8, CASP7, CDKN1A

Biological processes related to Gastrointestinal Lymphoma according to GeneCards/GeneDecks:

(show all 36)

id	Name	GO ID	Score	Top Affiliating Genes
1	DNA damage response, signal transduction by p53 class mediator	GO:030330	10.2	TP53, NBN
2	response to iron ion	GO:010039	10.2	BCL2, CCND1
3	response to organonitrogen compound	GO:010243	10.1	CDKN1A, CCND1
4	mitotic G1 DNA damage checkpoint	GO:031571	10.1	TP53, CCND1
5	response to corticosterone	GO:051412	10.1	CDKN1A, CCND1
6	mitotic cell cycle arrest	GO:071850	10.1	TP53, CDKN1A
7	B cell lineage commitment	GO:002326	10.1	BCL2, TP53
8	regulation of mitochondrial membrane permeability	GO:046902	10.1	BCL2, TP53
9	response to X-ray	GO:010165	10.1	TP53, CCND1
10	cellular response to glucose starvation	GO:042149	10.0	TP53, BCL2
11	response to ischemia	GO:002931	10.0	TP53, BCL2
12	cellular response to ionizing radiation	GO:071479	10.0	TP53, CDKN1A
13	positive regulation of reactive oxygen species metabolic process	GO:2000379	10.0	CDKN1A, TP53
14	response to antibiotic	GO:046677	10.0	CASP8, TP53
15	cell aging	GO:007569	10.0	TP53, BCL2
16	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	GO:042771	10.0	TP53, CDKN1A
17	response to gamma radiation	GO:010332	9.9	BCL2, TP53
18	positive regulation of B cell proliferation	GO:030890	9.9	CDKN1A, BCL2
19	T cell differentiation in thymus	GO:033077	9.9	BCL2, TP53
20	positive regulation of intrinsic apoptotic signaling pathway	GO:2001244	9.9	TP53, BCL2
21	extrinsic apoptotic signaling pathway via death domain receptors	GO:008625	9.9	BCL2, CASP8
22	cell cycle arrest	GO:007050	9.8	NBN, TP53, CDKN1A
23	neuron apoptotic process	GO:051402	9.8	BCL2, TP53
24	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	GO:035872	9.8	CASP8, BCL2
25	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	GO:1900740	9.8	TP53, BCL2, CASP8
26	negative regulation of cell growth	GO:030308	9.7	TP53, BCL2, CDKN1A
27	execution phase of apoptosis	GO:097194	9.7	CASP8, CASP7
28	response to drug	GO:042493	9.4	CDKN1A, BCL2, CCND1
29	cellular response to DNA damage stimulus	GO:006974	9.4	CDKN1A, BCL2, CCND1, TP53
30	negative regulation of apoptotic process	GO:043066	9.4	CD44, CDKN1A, BCL2, TP53
31	release of cytochrome c from mitochondria	GO:001836	9.3	CASP7, BCL2, TP53
32	positive regulation of neuron apoptotic process	GO:043525	9.1	TP53, CASP7
33	heart development	GO:007507	9.1	ADAP2, CASP8, CASP7
34	response to UV	GO:009411	9.0	CASP7, CDKN1A
35	apoptotic process	GO:006915	8.9	TP53, BCL2, CASP8, CASP7
36	intrinsic apoptotic signaling pathway	GO:097193	8.4	CDKN1A, NBN, TP53, BCL2, CASP8, CASP7

Molecular functions related to Gastrointestinal Lymphoma according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	protease binding	GO:002020	9.5	TP53, BCL2, CASP8
2	protein phosphatase 2A binding	GO:051721	9.4	BCL2, TP53
3	ubiquitin protein ligase binding	GO:031625	9.4	CASP8, BCL2, TP53
4	cysteine-type endopeptidase activity involved in apoptotic process	GO:097153	9.4	CASP7, CASP8
5	transcription factor binding	GO:008134	9.2	BCL2, CCND1, TP53, NBN
6	protein binding	GO:005515	6.6	NBN, TP53, ADAP2, CCND1, BCL2, CASP8