GANT
MCID: GST019
MIFTS: 83

Gastrointestinal Stromal Tumor (GANT) malady

Gastrointestinal diseases, Cancer diseases categories

Summaries for Gastrointestinal Stromal Tumor

About this section
Sources:
21Genetics Home Reference, 42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:42 Gastrointestinal stromal tumors are a type of soft tissue sarcoma (tumor) that usually begins in cells in the wall of the stomach, intestines, or rectum. these tumors may be noncancerous or cancerous. they can affect adults, adolescents, or children.  it is estimated that around 5,000 new cases of gastrointestinal stromal tumors are diagnosed in the united states each year. last updated: 4/27/2010

MalaCards: Gastrointestinal Stromal Tumor, also known as gastrointestinal stromal tumors, is related to neurofibromatosis and adenocarcinoma, and has symptoms including intestinal perforation, intestinal obstruction/ileus and gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia. An important gene associated with Gastrointestinal Stromal Tumor is SDHB (succinate dehydrogenase complex, subunit B, iron sulfur (Ip)), and among its related pathways are PIP3 activates AKT signaling and Nanog in Mammalian ESC Pluripotency. The compounds tyrosine and vegf have been mentioned in the context of this disorder. Affiliated tissues include small intestine, colon and liver, and related mouse phenotypes are mortality/aging and growth/size.

Genetics Home Reference:21 A gastrointestinal stromal tumor (GIST) is a type of tumor that occurs in the gastrointestinal tract, most commonly in the stomach or small intestine. The tumors are thought to grow from specialized cells found in the gastrointestinal tract called interstitial cells of Cajal (ICCs) or precursors to these cells. GISTs are usually found in adults between ages 40 and 70 and can be cancerous (malignant) or noncancerous (benign).

Wikipedia:63 Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal... more...

Description from OMIM:46 606764

Aliases & Classifications for Gastrointestinal Stromal Tumor

About this section
Sources:
8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 20GeneTests, 22GTR, 21Genetics Home Reference, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Gastrointestinal diseases


Characteristics (Orphanet epidemiological data):

48
gastrointestinal stromal tumor:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Adulthood


Aliases & Descriptions:

gastrointestinal stromal tumor 8 9 21 46 10 44 48
gastrointestinal stromal tumors 42 20 22 60
gist 8 42 21 48
gastrointestinal stromal sarcoma 42 21 60
stromal tumor of gastrointestinal tract 8
gastrointestinal stromal neoplasm 21
gant 8


External Ids:

Disease Ontology8 DOID:9253
NCIt39 C3868
MeSH34 D046152
OMIM46 606764
MESH via Orphanet35 D046152
ICD10 via Orphanet26 C26.9
SNOMED-CT via Orphanet57 128756002, 420120006
UMLS via Orphanet61 C0238198

Related Diseases for Gastrointestinal Stromal Tumor

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Gastrointestinal Stromal Tumor family:

Gastrointestinal Stromal Tumor, Familial

Diseases related to Gastrointestinal Stromal Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 285)
idRelated DiseaseScoreTop Affiliating Genes
1neurofibromatosis31.2KIT, NF2, SDHB, PDGFRA, S100B, KITLG
2adenocarcinoma31.0VIM, NF2, PDGFRB, NES, ACTC1, KITLG
3leiomyoma31.0VIM, S100B, S100A1, PDGFRA, NES, ACTC1
4leiomyosarcoma30.9VIM, S100B, ACTC1, KIT, CD34, DES
5pancreatitis30.9KITLG
6sarcoma30.8KIT, ACTC1, KITLG, CD34, VIM, S100B
7leukemia30.7NES, PDGFRA, PDGFRB, CD34, KITLG, KIT
8smooth muscle tumor30.7ACTC1, DES, S100A1, KIT, VIM, S100B
9paraganglioma30.7S100A1, SDHB, SDHC, SDHA, S100B, KIT
10pheochromocytoma30.6SDHB, SDHC, SDHA
11myeloid leukemia30.6KITLG, CD34, KIT
12melanoma30.5CD34, KITLG, KIT, NF2, PDGFRB, ACTC1
13giant cell tumor30.5ACTC1, S100B, DES, VIM
14malignant peripheral nerve sheath tumor30.3KIT, CD34, NF2, S100A1, S100B, VIM
15adenoma30.3S100A1, SV2A, KITLG, NES, ACTC1
16granular cell tumor30.3S100B, VIM, S100A1, DES
17acute leukemia30.3KIT, KITLG, CD34
18gastrointestinal stromal tumor, somatic30.3KIT, PDGFRA
19paraganglioma and gastric stromal sarcoma30.3SDHB, SDHC
20neurofibroma30.1VIM, S100A1, KITLG, CD34, NF2, PDGFRA
21breast cancer30.1ETV1, NES, KIT, SDHC, SDHB, NF2
22hemangiopericytoma30.1DES, CD34, VIM, S100B, ACTC1, S100A1
23meningioma30.1PDGFRB, NF2, S100A1, S100B, CD34, VIM
24glomus tumor30.1SDHB, ACTC1, DES, S100A1, VIM
25synovial sarcoma30.1KIT, VIM, S100B, NES, DES
26colorectal cancer30.1CD34, KITLG, PDGFRB, NF2, PDGFRA
27angiosarcoma30.1CD34, PDGFRA, VIM, ACTC1
28chronic myeloid leukemia30.1KITLG, KIT, PDGFRB, PDGFRA, CD34
29perineurioma30.1VIM, CD34, S100B
30ovarian cancer30.1NF2, PDGFRA, PDGFRB, CD34
31osteosarcoma30.1PDGFRA, NF2, PDGFRB
32chondroma30.1SDHC, PDGFRA, SDHB
33polycythemia vera30.1KITLG, PDGFRA, PDGFRB, KIT
34polycythemia30.1CD34, KITLG
35adenosarcoma30.1ACTC1, DES
36stomach cancer30.1SDHB, CD34
37hepatocellular carcinoma30.1PDGFRA, CD34
38urticaria pigmentosa30.1KITLG, KIT
39liposarcoma29.8CD34, VIM, DES
40clear cell sarcoma29.8KIT, S100B
41duodenitis10.7
42esophagitis10.6
43intussusception10.5
44gastric adenocarcinoma10.5
45gastrointestinal lymphoma10.5
46hypoglycemia10.5
47prostatitis10.5
48meckel's diverticulum10.4
49gastrointestinal neuroendocrine tumor10.4
50neuroendocrine tumor10.4

Graphical network of the top 20 diseases related to Gastrointestinal Stromal Tumor:



Diseases related to gastrointestinal stromal tumor

Clinical Features for Gastrointestinal Stromal Tumor

About this section
Sources:
46OMIM, 48Orphanet
See all sources

Clinical features from OMIM:

606764

Clinical synopsis from OMIM:

606764

Symptoms:

48 (show all 18)
  • intestinal perforation
  • intestinal obstruction/ileus
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • constipation
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia
  • sarcoma
  • asthenia/fatigue/weakness
  • cutaneous rash
  • irregular/in bands/reticular skin hyperpigmentation
  • hepatitis/icterus/cholestasis
  • anaemia
  • digestive neoplasm/tumor/carcinoma/cancer
  • esophageal neoplasm/tumor/carcinoma/cancer
  • small bowel neoplasm/tumor/carcinoma/cancer
  • colon neoplasm/tumor/carcinoma/cancer
  • rectum/rectal neoplasm/tumor/carcinoma/cancer
  • estomach/gastric neoplasm/tumor/carcinoma/cancer

Drugs & Therapeutics for Gastrointestinal Stromal Tumor

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Gastrointestinal Stromal Tumor

Drug clinical trials:

Search ClinicalTrials for Gastrointestinal Stromal Tumor

Search NIH Clinical Center for Gastrointestinal Stromal Tumor

Search CenterWatch for Gastrointestinal Stromal Tumor

Genetic Tests for Gastrointestinal Stromal Tumor

About this section
Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Gastrointestinal Stromal Tumor:

id Genetic test Affiliating Genes
1 Gastrointestinal Stromal Tumor20 PDGFRA
2 Gastrointestinal Stromal Tumors22

Anatomical Context for Gastrointestinal Stromal Tumor

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Gastrointestinal Stromal Tumor:

32
Small intestine, Colon, Liver, Bone, Skin, Pancreas, Smooth muscle, Prostate, Endothelial, Appendix, Myeloid, Lymph node, Testes, Thyroid, Brain, Breast, Ovary, Uterus, Skeletal muscle, B cells, Tongue, Heart, T cells, Spleen, Bone marrow

Animal Models for Gastrointestinal Stromal Tumor or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Gastrointestinal Stromal Tumor:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076811.5SDHC, ACTC1, KIT, KITLG, SV2A, ETV1
2MP:000537811.3NES, ETV1, SV2A, KITLG, KIT, ACTC1
3MP:000538611.3ETV1, SV2A, PDGFRA, VIM, S100B, S100A1
4MP:000363111.0SV2A, TLX2, ANO1, NF2, ETV1, KITLG
5MP:000538011.0NF2, KITLG, KIT, NES, PDGFRA, TLX2
6MP:000538411.0NES, VIM, SV2A, CD34, ETV1, KITLG
7MP:000536911.0PDGFRB, PDGFRA, ANO1, ETV1, ACTC1
8MP:000287311.0PDGFRB, S100A1, PDGFRA, ETV1, SV2A, KIT
9MP:000537610.9VIM, PDGFRB, PDGFRA, DES, ACTC1, KITLG
10MP:001077110.9CD34, ANO1, PDGFRA, S100B, KITLG
11MP:000538210.8KIT, KITLG, NF2, PDGFRA, PDGFRB, TLX2
12MP:000538510.6PDGFRA, DES, KITLG, KIT, ACTC1, S100A1

Publications for Gastrointestinal Stromal Tumor

About this section
Sources:
50PubMed
See all sources

Articles related to Gastrointestinal Stromal Tumor:

(show top 50)    (show all 1106)
idTitleAuthorsYear
1
Gastrointestinal stromal tumor of small intestine and synchronous bilateral papillary renal cell carcinoma. (24195178)
2013
2
Esophageal gastrointestinal stromal tumor: diagnostic complexity and management pitfalls. (23738186)
2013
3
Robot-assisted laparoscopic resection for gastric gastrointestinal stromal tumor. (22678340)
2012
4
Imatinib-associated bilateral gynecomastia and unilateral testicular hydrocele in male patient with metastatic gastrointestinal stromal tumor: a literature review. (22009701)
2012
5
Caecal gastrointestinal stromal tumor with perforation and obstruction. (24293969)
2012
6
Synchronous appearance of gastrointestinal stromal tumor and neuroendocrine tumor in stomach: review of the literature and management strategies. (22798116)
2012
7
KRAS and BRAF mutations predict primary resistance to imatinib in gastrointestinal stromal tumors. (22282465)
2012
8
CT features, mimics and atypical presentations of gastrointestinal stromal tumor (GIST). (22013291)
2011
9
Discovered on gastrointestinal stromal tumor 1 (DOG1) is expressed in pancreatic centroacinar cells and in solid-pseudopapillary neoplasms--novel evidence for a histogenetic relationship. (21295818)
2011
10
Dual energy CT for monitoring targeted therapies in patients with advanced gastrointestinal stromal tumor: initial results. (21342100)
2011
11
Successful treatment with sunitinib in a young patient with metastatic gastrointestinal stromal tumor after failure on adjuvant imatinib. (22269418)
2011
12
Primary Malignant Gastrointestinal Stromal Tumor (GIST) of the Gallbladder: Report of a Case. (22086710)
2011
13
Response assessment in gastrointestinal stromal tumor. (20957633)
2011
14
Extra-gastrointestinal stromal tumor of the pancreas: clinical characteristics, diagnosis, treatment, and outcome. (21240986)
2011
15
A distinct pediatric-type gastrointestinal stromal tumor in adults: potential role of succinate dehydrogenase subunit A mutations. (21997697)
2011
16
CT findings of primary extra-intestinal gastrointestinal stromal tumor of greater omentum with extensive peritoneal and bilateral ovarian metastases. (21330768)
2011
17
Chromosome copy number changes carry prognostic information independent of KIT/PDGFRA point mutations in gastrointestinal stromal tumors. (20470368)
2010
18
Malignant gastrointestinal stromal tumor presenting with hemoperitoneum in puerperium: report of a case with review of the literature. (21054898)
2010
19
Commentary: gastrointestinal stromal tumor. (20463548)
2010
20
Large gastrointestinal stromal tumor size does not imply early recurrence. (23754882)
2010
21
Cytoreductive surgery in patients with metastatic gastrointestinal stromal tumor treated with sunitinib malate. (19898902)
2010
22
Local resection of gastrointestinal stromal tumor of the second part of duodenum. (22049897)
2010
23
Gastrointestinal stromal tumors presenting as a prostatic mass. (19222892)
2009
24
Gastrointestinal stromal tumor of the uterus: a case report with genetic analyses of c-kit and PDGFRA genes. (19047911)
2009
25
Comparison of tissue microarray and full section in immunohistochemistry of gastrointestinal stromal tumors. (20021609)
2009
26
KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients. (19164557)
2009
27
An acute hepatitis resembling autoimmune hepatitis occurring during imatinib therapy in a gastrointestinal stromal tumor patient. (19955903)
2009
28
Gastrointestinal stromal tumor with autonomic nerve differentiation and coexistent mantle cell lymphoma involving the appendix. (19636397)
2009
29
Effect of c-kit mutation on the prognosis of gastrointestinal stromal tumors: a meta-analysis]. (19961019)
2009
30
Evolution from heterozygous to homozygous KIT mutation in gastrointestinal stromal tumor correlates with the mechanism of mitotic nondisjunction and significant tumor progression. (18488000)
2008
31
Familial gastrointestinal stromal tumors and germ-line mutations. (17804857)
2007
32
Synchronous gastric gastrointestinal stromal tumor and signet-ring cell adenocarcinoma: a case report. (17913950)
2007
33
Gastrointestinal stromal tumors express the orexigen ghrelin. (16954444)
2006
34
Early effects of imatinib mesylate on the expression of insulin-like growth factor binding protein-3 and positron emission tomography in patients with gastrointestinal stromal tumor. (16986125)
2006
35
Allelic loss of Hox11L1 gene locus predicts outcome of gastrointestinal stromal tumors. (16969514)
2006
36
Immunohistochemical and genetic features of gastric and metastatic liver gastrointestinal stromal tumors: sequential analyses. (16441423)
2006
37
Treatment of gastrointestinal stromal tumors with imatinib mesylate: a major breakthrough in the understanding of tumor-specific molecular characteristics. (15706444)
2005
38
Analysis of CD117-negative gastrointestinal stromal tumors. (15742414)
2005
39
Multivariate analysis of prognosis in gastrointestinal stromal tumor]. (16438868)
2005
40
Gastrointestinal stromal tumors: insights from a new familial GIST kindred with unusual genetic and pathologic features. (16327443)
2005
41
Estimation of the malignant potential of gastrointestinal stromal tumors: the value of contrast-enhanced coded phase-inversion harmonics US. (15830283)
2005
42
Prognostic value of KIT mutation in gastrointestinal stromal tumors. (15991300)
2005
43
Papillary renal cell carcinoma and gastrointestinal stromal tumor: a unique association. (15111359)
2004
44
Evaluation of prognosis for malignant rectal gastrointestinal stromal tumor by clinical parameters and immunohistochemical staining. (15622586)
2004
45
Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors. (12949711)
2003
46
Role of imatinib mesylate (Gleevec/Glivec) in gastrointestinal stromal tumors. (14686698)
2003
47
Study of gastrointestinal stromal tumors by light microscopy, electron microscopy and immunohistochemistry. (12475434)
2002
48
Somatostatinoma of the papilla of Vater with multiple gastrointestinal stromal tumors in a patient with von Recklinghausen's disease. (12483251)
2002
49
Germline mutation in the juxtamembrane domain of the kit gene in a family with gastrointestinal stromal tumors and urticaria pigmentosa. (11505412)
2001
50
Spindle cell tumor of urinary bladder serosa with phenotypic and genotypic features of gastrointestinal stromal tumor. (10835530)
2000

Genetic Variations for Gastrointestinal Stromal Tumor

About this section
Sources:
62UniProtKB/Swiss-Prot
See all sources

Genetic disease variations for Gastrointestinal Stromal Tumor:

62
id Symbol AA change Variation ID SNP ID
1KITp.Lys550IleVAR_033123rs28933968
2KITp.Val559AlaVAR_033126
3KITp.Val559AspVAR_033127
4PDGFRAp.Tyr849CysVAR_066474

Expression for genes affiliated with Gastrointestinal Stromal Tumor

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Gastrointestinal Stromal Tumor

Search GEO for disease gene expression data for Gastrointestinal Stromal Tumor.

Pathways for genes affiliated with Gastrointestinal Stromal Tumor

About this section
Sources:
53Reactome, 51QIAGEN, 4Cell Signaling Technology, 12EMD Millipore, 37NCBI BioSystems Database, 29KEGG, 49PharmGKB
See all sources

Pathways related to Gastrointestinal Stromal Tumor according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.8PDGFRB, PDGFRA, KITLG, S100B, KIT
2
Hide members
10.7KITLG, PDGFRA, PDGFRB, VIM, KIT
3
Hide members
10.7KITLG, ETV1, PDGFRA, PDGFRB, KIT
4
Hide members
10.7PDGFRA, KITLG, KIT, PDGFRB
510.7PDGFRB, PDGFRA, KITLG, KIT
6
Hide members
10.7KIT, KITLG, PDGFRB, PDGFRA
7
Hide members
10.7PDGFRA, PDGFRB, VIM, DES
810.7DES, ACTC1, VIM, NF2
9
Hide members
10.6SDHC, SDHA, SDHB
10
Hide members
10.6SDHC, SDHA, SDHB
11
Hide members
10.6SDHA, SDHC, SDHB
1210.6PDGFRA, KIT, ACTC1
13
Hide members
10.6PDGFRB, KIT, PDGFRA
1410.6PDGFRB, PDGFRA, NF2
15
Hide members
10.6VIM, DES, ACTC1
16
Hide members
10.6DES, NES, VIM
1710.6KIT, KITLG, CD34
1810.6KIT, KITLG, CD34
1910.6PDGFRA, PDGFRB

Compounds for genes affiliated with Gastrointestinal Stromal Tumor

About this section
Sources:
44Novoseek, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB
See all sources

Compounds related to Gastrointestinal Stromal Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1tyrosine4411.7NES, SV2A, CD34, KITLG, NF2, DES
2vegf4411.6PDGFRA, PDGFRB, S100B, VIM, SDHC, NES
3paraffin4411.6KIT, ACTC1, VIM, S100B, S100A1, PDGFRB
4retinoic acid44 2412.6S100B, PDGFRB, VIM, PDGFRA, DES, CD34
5progesterone44 59 28 11 2415.4CD34, PDGFRB, ACTC1, NF2, DES, KIT
6calcium44 49 11 2414.4KITLG, S100B, DES, ANO1, SV2A, KIT
7iron44 2412.4S100B, S100A1, DES, KITLG, ACTC1, SDHB
8testosterone44 59 11 2414.4VIM, ACTC1, SDHB, KIT, ETV1, PDGFRB
9hematoxylin4411.3S100A1, CD34, KIT, ACTC1, S100B, VIM
10imatinib44 49 1113.3S100B, PDGFRA, PDGFRB, KIT, DES, KITLG
11oxygen44 2412.3S100B, NES, DES, KITLG, SDHB, SDHC
12cysteine4411.3S100A1, S100B, SDHB, KIT, NF2, DES
13bromodeoxyuridine4411.2S100B, VIM, NES, KITLG, DES, PDGFRB
14toluidine4411.2DES, KITLG, KIT, VIM, S100A1
15reticulin4411.2VIM, S100B, DES, ACTC1, CD34
16rapamycin4411.2KITLG, KIT, PDGFRB, NF2, VIM, PDGFRA
17mucicarmine4411.2S100B, ACTC1, DES, S100A1, VIM
18b 7234411.2VIM, S100B, ACTC1, S100A1, DES
19biotin44 11 2413.1DES, S100A1, VIM, ACTC1, KITLG
20formaldehyde44 2412.1VIM, S100B, KIT, ACTC1, DES
21orcein4411.1ACTC1, DES, S100B, VIM
22s 1004411.1VIM, ACTC1, S100B, DES
23lactate4411.1SDHB, S100B, KITLG, VIM, DES, KIT
24ag-12964411.1PDGFRA, PDGFRB, KITLG, KIT
25thymidine44 2412.1KIT, KITLG, S100B, CD34, PDGFRA, DES
26glycogen44 2412.0KIT, SDHB, ACTC1
27UBIQUINONE-11111.0SDHA, SDHC, SDHB
28glucose4411.0SDHB, ACTC1, KITLG, PDGFRB
29agar4411.0NF2, CD34, PDGFRB, KITLG, VIM
30monochloroacetic acid4411.0KITLG, KIT, VIM
31acetylcholine44 49 28 11 2415.0S100A1, NES, SV2A
32pkc 4124411.0KIT, PDGFRA, PDGFRB
33ganglioside4411.0PDGFRB, DES, NES, VIM
342-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol1111.0SDHA, SDHC, SDHB
352-methoxyethanol4411.0S100A1, VIM, ACTC1
36su54164411.0KITLG, PDGFRB, KIT
37Pazopanib1111.0KIT, PDGFRA, PDGFRB
38methionine4410.9PDGFRB, VIM, DES, S100B, KIT
39fluorochrome4410.9KIT, CD34, VIM
40rhodamine 12344 4911.9KITLG, CD34, KIT
41creatinine4410.9ACTC1, SDHB, KITLG
42Regorafenib1110.9KIT, PDGFRA, PDGFRB
43sunitinib44 49 1112.8PDGFRA, KIT, PDGFRB
44iron-sulfur4410.8SDHB, SDHC, SDHA
45paclitaxel44 49 1112.7S100B, PDGFRB
46succinic acid28 11 2412.7SDHC, SDHA, SDHB
47ubiquinone4410.6SDHA, SDHB, SDHC
48actomyosin4410.6ACTC1, S100A1, VIM
49gold4410.5SV2A, DES
50Becaplermin1110.3PDGFRB, PDGFRA

GO Terms for genes affiliated with Gastrointestinal Stromal Tumor

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Gastrointestinal Stromal Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573711.1ACTC1, VIM, TLX2, S100B, PDGFRB, PDGFRA
2mitochondrial respiratory chain complex IIGO:00574910.6SDHB, SDHC, SDHA
3intermediate filamentGO:00588210.6DES, NES, VIM
4intrinsic to plasma membraneGO:03122610.3PDGFRA, PDGFRB

Biological processes related to Gastrointestinal Stromal Tumor according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1phosphatidylinositol-mediated signalingGO:04801511.0PDGFRB, PDGFRA, KITLG, KIT
2positive regulation of phospholipase C activityGO:01086311.0KIT, PDGFRA, PDGFRB
3cardiac myofibril assemblyGO:05500311.0ACTC1, PDGFRA, PDGFRB
4cell chemotaxisGO:06032611.0PDGFRB, PDGFRA, KIT
5positive regulation of phosphatidylinositol 3-kinase activityGO:04355211.0KIT, PDGFRA, PDGFRB
6tricarboxylic acid cycleGO:00609911.0SDHA, SDHC, SDHB
7fibroblast growth factor receptor signaling pathwayGO:00854311.0KIT, KITLG, PDGFRA, PDGFRB
8muscle filament slidingGO:03004910.9VIM, DES, ACTC1
9Fc-epsilon receptor signaling pathwayGO:03809510.9KIT, KITLG, PDGFRA, PDGFRB
10positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathwayGO:03809110.9PDGFRA, PDGFRB
11positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406810.9PDGFRB, PDGFRA, KIT
12metanephric glomerular capillary formationGO:07227710.9PDGFRA, PDGFRB
13epidermal growth factor receptor signaling pathwayGO:00717310.9PDGFRB, PDGFRA, KITLG, KIT
14germ cell programmed cell deathGO:03523410.9KIT, KITLG
15peptidyl-tyrosine phosphorylationGO:01810810.8PDGFRB, PDGFRA, KIT
16hemopoiesisGO:03009710.8KIT, KITLG, CD34
17innate immune responseGO:04508710.8KIT, KITLG, PDGFRA, PDGFRB, S100B
18stem cell proliferationGO:07208910.7NES, CD34
19retina vasculature development in camera-type eyeGO:06129810.7PDGFRB, PDGFRA
20succinate metabolic processGO:00610510.6SDHA, SDHB
21respiratory electron transport chainGO:02290410.5SDHA, SDHC, SDHB
22neurotrophin TRK receptor signaling pathwayGO:04801110.4PDGFRB, PDGFRA, KITLG, KIT

Molecular functions related to Gastrointestinal Stromal Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.3PDGFRB, VIM, S100B, S100A1, PDGFRA, DDX39A
2succinate dehydrogenase (ubiquinone) activityGO:00817710.7SDHB, SDHA
3vascular endothelial growth factor bindingGO:03808510.6PDGFRA, PDGFRB
4platelet-derived growth factor receptor bindingGO:00516110.6PDGFRB, PDGFRA
5S100 protein bindingGO:04454810.5S100B, S100A1
6platelet-derived growth factor bindingGO:04840710.3PDGFRA, PDGFRB

Products for genes affiliated with Gastrointestinal Stromal Tumor

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gastrointestinal Stromal Tumor

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet