GANT
MCID: GST019
MIFTS: 75

Gastrointestinal Stromal Tumor (GANT) malady

Gastrointestinal, Cancer categories

Summaries for Gastrointestinal Stromal Tumor

Sources:
43NIH Rare Diseases, 21Genetics Home Reference, 64Wikipedia, 47OMIM, 33MalaCards
See all sources

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NIH Rare Diseases:43 Gastrointestinal stromal tumors are a type of soft tissue sarcoma (tumor) that usually begins in cells in the wall of the stomach, intestines, or rectum. these tumors may be noncancerous or cancerous. they can affect adults, adolescents, or children.  it is estimated that around 5,000 new cases of gastrointestinal stromal tumors are diagnosed in the united states each year. last updated: 4/27/2010

MalaCards: Gastrointestinal Stromal Tumor, also known as gastrointestinal stromal tumors, is related to neurofibromatosis and adenocarcinoma, and has symptoms including nausea/vomiting/regurgitation/merycism/hyperemesis, feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia and constipation. An important gene associated with Gastrointestinal Stromal Tumor is SDHB (succinate dehydrogenase complex, subunit B, iron sulfur (Ip)), and among its related pathways are PIP3 activates AKT signaling and Nanog in Mammalian ESC Pluripotency. The compounds tyrosine and vegf have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and liver, and related mouse phenotypes are mortality/aging and growth/size.

Genetics Home Reference:21 A gastrointestinal stromal tumor (GIST) is a type of tumor that occurs in the gastrointestinal tract, most commonly in the stomach or small intestine. The tumors are thought to grow from specialized cells found in the gastrointestinal tract called interstitial cells of Cajal (ICCs) or precursors to these cells. GISTs are usually found in adults between ages 40 and 70 and can be cancerous (malignant) or noncancerous (benign).

Wikipedia:64 Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal... more...

Description from OMIM:47 606764

Aliases & Classifications for Gastrointestinal Stromal Tumor

Sources:
8Disease Ontology, 9diseasecard, 43NIH Rare Diseases, 20GeneTests, 22GTR, 21Genetics Home Reference, 47OMIM, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 40NCIt, 35MeSH, 57SNOMED-CT, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Gastrointestinal


Characteristics (Orphanet epidemiological data):

49
gastrointestinal stromal tumor:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Adulthood


Aliases & Descriptions:

gastrointestinal stromal tumor 8 9 21 47 10 45 49
gastrointestinal stromal tumors 43 20 22 61
gist 8 43 21 49
gastrointestinal stromal sarcoma 43 21 61
stromal tumor of gastrointestinal tract 8
gastrointestinal stromal neoplasm 21
gant 8


External Ids:

Disease Ontology8 DOID:9253
NCIt40 C3868
MeSH35 D046152
OMIM47 606764
MESH via Orphanet36 D046152
ICD10 via Orphanet26 C26.9
SNOMED-CT via Orphanet58 128756002, 420120006
UMLS via Orphanet62 C0238198

Related Diseases for Gastrointestinal Stromal Tumor

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Gastrointestinal Stromal Tumor family:

gastrointestinal stromal tumor, familial

Diseases related to Gastrointestinal Stromal Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 252)
idRelated DiseaseScoreTop Affiliating Genes
1neurofibromatosis31.2S100B, PDGFRA, SDHC, SDHB, KIT, KITLG
2adenocarcinoma31.1VIM, PDGFRB, NES, NF2, SV2A, CD34
3fibromatosis30.9ACTC1, KIT, CD34, DES, PDGFRB, S100A1
4smooth muscle tumor30.7VIM, S100B, S100A1, DES, KIT, ACTC1
5paraganglioma30.7S100B, S100A1, KIT, SDHB, SDHC, SDHA
6carney triad30.7SDHB, KIT, PDGFRA, SDHC
7desmoid tumor30.6PDGFRB, PDGFRA, DES, KIT, ACTC1
8adenoma30.6S100A1, NES, SV2A, KITLG, ACTC1
9pheochromocytoma30.6SDHA, SDHC, SDHB
10gastrointestinal stromal tumor, somatic30.6PDGFRA, KIT
11granular cell tumor30.4DES, S100A1, S100B, VIM
12rhabdoid tumor30.4VIM, DES, ACTC1
13acute leukemia30.4CD34, KITLG, KIT
14paraganglioma and gastric stromal sarcoma30.4SDHB, SDHC
15dermatofibrosarcoma protuberans30.2S100B, VIM, S100A1, PDGFRB, DES, ACTC1
16synovial sarcoma30.2VIM, S100B, NES, DES, KIT
17colorectal cancer30.2KITLG, CD34, NF2, PDGFRA, PDGFRB
18angiosarcoma30.2ACTC1, CD34, PDGFRA, VIM
19mastocytosis30.2PDGFRB, PDGFRA, KITLG, KIT
20chronic myeloid leukemia30.2PDGFRB, PDGFRA, CD34, KITLG, KIT
21polycythemia vera30.2KIT, KITLG, PDGFRA, PDGFRB
22adenosarcoma30.2DES, ACTC1
23stomach cancer30.2CD34, SDHB
24multiple endocrine neoplasia30.2NF2, SDHB, SDHC
25urticaria pigmentosa30.2KITLG, KIT
26thymic carcinoma29.8KIT
27clear cell sarcoma29.8S100B, KIT
28gastrointestinal stromal tumor, familial10.7
29intussusception10.6
30meckel's diverticulum10.5
31gastrointestinal lymphoma10.5
32hypoglycemia10.5
33gastrointestinal adenoma10.4
34papillary carcinoma10.4
35papillary renal cell carcinoma10.4
36somatostatinoma10.4
37papillary renal carcinoma10.4
38crohn's disease10.3
39acute pancreatitis10.3
40neuroendocrine carcinoma10.3
41renal clear cell carcinoma10.3
42acute myeloid leukemia10.3
43familial adenomatous polyposis10.3
44gynecomastia10.3
45hyperinsulinemic hypoglycemia10.3
46mantle cell lymphoma10.3
47n syndrome10.3
48stomach disease10.3
49clear cell renal cell carcinoma10.3
50hypoxia10.3

Graphical network of the top 20 diseases related to Gastrointestinal Stromal Tumor:



Diseases related to gastrointestinal stromal tumor

Clinical Features for Gastrointestinal Stromal Tumor

Sources:
47OMIM, 49Orphanet
See all sources

Clinical features from OMIM:

606764

Clinical synopsis from OMIM:

606764

Symptoms:

49 (show all 18)
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia
  • constipation
  • asthenia/fatigue/weakness
  • hepatitis/icterus/cholestasis
  • anaemia
  • cutaneous rash
  • irregular/in bands/reticular skin hyperpigmentation
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • intestinal obstruction/ileus
  • colon neoplasm/tumor/carcinoma/cancer
  • sarcoma
  • digestive neoplasm/tumor/carcinoma/cancer
  • intestinal perforation
  • estomach/gastric neoplasm/tumor/carcinoma/cancer
  • small bowel neoplasm/tumor/carcinoma/cancer
  • esophageal neoplasm/tumor/carcinoma/cancer
  • rectum/rectal neoplasm/tumor/carcinoma/cancer

Drugs & Therapeutics for Gastrointestinal Stromal Tumor

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Gastrointestinal Stromal Tumor

Drug clinical trials:

Search ClinicalTrials for Gastrointestinal Stromal Tumor

Search NIH Clinical Center for Gastrointestinal Stromal Tumor

Search CenterWatch for Gastrointestinal Stromal Tumor

Genetic Tests for Gastrointestinal Stromal Tumor

Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Gastrointestinal Stromal Tumor:

id Genetic test Affiliating Genes
1 Gastrointestinal Stromal Tumor20 PDGFRA
2 Gastrointestinal Stromal Tumors22

Anatomical Context for Gastrointestinal Stromal Tumor

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Gastrointestinal Stromal Tumor:

33
Skin, Ovary, Liver, Tongue, Brain, Lymph node, Spleen, Uterus, Bone marrow, Whole blood, Heart, Smooth muscle, Skeletal muscle, Small intestine, Colon, Pancreas, Thyroid, Breast, Prostate, Myeloid, T cells, B cells, Endothelial, Appendix, Pancreatic islet

Animal Models for Gastrointestinal Stromal Tumor or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Gastrointestinal Stromal Tumor

Sources:
51PubMed
See all sources

Articles related to Gastrointestinal Stromal Tumor:

(show top 50)    (show all 1108)
idTitleAuthorsYear
1
Gastrointestinal stromal tumor: an unusual cause of gastrointestinal bleeding. (23633157)
2013
2
DOG1 is useful for diagnosis of KIT-negative gastrointestinal stromal tumor of stomach. (24379641)
2013
3
Multiple liver abscess formation and primary gastrointestinal stromal tumor. (24179663)
2013
4
Gastrointestinal stromal tumor of the stomach. (23945486)
2013
5
BRAF mutant gastrointestinal stromal tumor: first report of regression with BRAF inhibitor dabrafenib (GSK2118436) and whole exomic sequencing for analysis of acquired resistance. (23470635)
2013
6
Surgical treatment of a giant mesenteric fibromatosis mimicking a gastrointestinal stromal tumor: a case report and current treatment aspects. (23175930)
2012
7
Effectiveness of adjuvant imatinib in patients with gastrointestinal stromal tumor: results of a population-based, matched-cohort study. (22506625)
2012
8
Expression and significance of twist, E-cadherin, and N-cadherin in gastrointestinal stromal tumors. (22576709)
2012
9
Gastrointestinal stromal tumor: psychosocial characteristics and considerations. (22426502)
2012
10
Gastrointestinal stromal tumor in the duodenal blind spot: role of pediatric colonoscope and endoscopic ultrasound. (23082718)
2012
11
ACRIN 6665/RTOG 0132 phase II trial of neoadjuvant imatinib mesylate for operable malignant gastrointestinal stromal tumor: monitoring with 18F-FDG PET and correlation with genotype and GLUT4 expression. (22381410)
2012
12
Orbital gastrointestinal stromal tumor metastasis. (22489857)
2012
13
Gastrointestinal stromal tumor presenting as a rectovaginal mass. Clinicopathologic and molecular-genetic characterization of a rare tumor with a literature review. (21237497)
2011
14
Response to imatinib rechallenge in a patient with a recurrent gastrointestinal stromal tumor after adjuvant therapy: a case report. (21975443)
2011
15
A case of gossypiboma masquerading as a gastrointestinal stromal tumor. (22741113)
2011
16
Totally laparoscopic resection for a large gastrointestinal stromal tumor of stomach. (22324017)
2011
17
Extra-gastrointestinal stromal tumor presenting as a surgical emergency. (22287408)
2011
18
DOG1 antibody is a highly sensitive and specific marker for gastrointestinal stromal tumors in cytology cell blocks. (21350101)
2011
19
Clinical practice guideline for accurate diagnosis and effective treatment of gastrointestinal stromal tumor in Korea. (21060741)
2010
20
Gastrointestinal stromal tumors: a paradigm for therapeutic options in solid organ tumors. (20500152)
2010
21
Reduced expression of PTEN protein and its prognostic significance in the gastrointestinal stromal tumor. (20407866)
2010
22
Imatinib mesylate for the treatment of gastrointestinal stromal tumor. (20469993)
2010
23
Gastrointestinal stromal tumor in a patient with undiagnosed neurofibromatosis type I: an uncommon cause of extrahepatic cholestasis. (20352594)
2010
24
Segmental duodenectomy for gastrointestinal stromal tumor of the duodenum. (20533599)
2010
25
Gastrointestinal stromal tumor: Role of surgery and immunotherapy. (21170201)
2010
26
Gastrointestinal stromal tumor of the stomach: How to manage? (21160626)
2010
27
Gastrointestinal stromal tumor (GIST) recurrence following surgery: review of the clinical utility of imatinib treatment. (20957137)
2010
28
Mesenteric gastrointestinal stromal tumor. (20373839)
2010
29
Gastrointestinal stromal tumor: an ultrastructural investigation on regional differences with considerations on their histogenesis. (20455665)
2010
30
Friend leukemia virus integration-1 (FLI-1) expression in gastrointestinal stromal tumors. (19530039)
2009
31
A case of von Recklinghausen's disease with coincident malignant peripheral nerve sheath tumor and gastrointestinal stromal tumor. (19262018)
2009
32
Gastrointestinal stromal tumors: past, present, and future. (18648736)
2008
33
A gastrointestinal stromal tumor in a patient with multiple endocrine neoplasia type 2A and metastatic medullary thyroid cancer to the ovaries. (18996821)
2008
34
A novel monoclonal antibody against DOG1 is a sensitive and specific marker for gastrointestinal stromal tumors. (18223323)
2008
35
A 17 year-old man with an exon 11 mutation of CD-117 causing a gastrointestinal stromal tumor. (18259950)
2008
36
Symptomatic hypoglycemia during imatinib mesylate in a non-diabetic female patient with gastrointestinal stromal tumor. (17923802)
2007
37
The role of KIT in the management of patients with gastrointestinal stromal tumors. (17437861)
2007
38
Interobserver variability in histologic recognition, interpretation of KIT immunostaining, and determining MIB-1 labeling indices in gastrointestinal stromal tumors and other spindle cell tumors of the gastrointestinal tract. (16540730)
2006
39
Predicting the antitumor effects of STI571 by analysis of c-kit gene mutations in gastrointestinal stromal tumors of the stomach: Report of a case. (17072721)
2006
40
Novel NF1 gene mutation in a Japanese patient with neurofibromatosis type 1 and a gastrointestinal stromal tumor. (16741618)
2006
41
Advanced-stage gastrointestinal stromal tumor treated with imatinib in a 12-year-old girl with a unique mutation of PDGFRA. (16291174)
2005
42
High expression of both mutant and wild-type alleles of c-kit in gastrointestinal stromal tumors. (15062876)
2004
43
Recent advances in cell biology, diagnosis, and therapy of gastrointestinal stromal tumor (GIST). (14726714)
2004
44
Gastrointestinal stromal tumors carrying PDGFRalpha mutations occur preferentially in the stomach and exhibit an epithelioid or mixed phenotype]. (16892550)
2004
45
Expression of human telomerase reverse transcriptase in gastrointestinal stromal tumors occurs preferentially in malignant neoplasms. (15492990)
2004
46
Expression of vascular endothelial growth factor and angiogenesis in gastrointestinal stromal tumor of the stomach. (12697968)
2003
47
Mutations in exon 11 of the c-kit gene in a myogenic tumor and a neurogenic tumor as well as in gastrointestinal stromal tumors. Utility of c-kit mutation as a prognostic biomarker for gastrointestinal mesenchymal tumor. (12759497)
2003
48
Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors. gastrointestinal stromal tumors. (12072198)
2002
49
Different patterns of DNA copy number changes in gastrointestinal stromal tumors, leiomyomas, and schwannomas. (9596271)
1998
50
Apoptotic gastrointestinal stromal tumor--AGIST]. (1340400)
1992

Genetic Variations for Gastrointestinal Stromal Tumor

Sources:
63UniProtKB/Swiss-Prot
See all sources

Genetic disease variations for Gastrointestinal Stromal Tumor:

63
id Symbol AA change Variation SNP ID
1KITp.Lys550IleVAR_033123rs28933968
2KITp.Val559AlaVAR_033126
3KITp.Val559AspVAR_033127
4PDGFRAp.Tyr849CysVAR_066474

Expression for genes affiliated with Gastrointestinal Stromal Tumor

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Gastrointestinal Stromal Tumor

Search GEO for disease gene expression data for Gastrointestinal Stromal Tumor.

Pathways for genes affiliated with Gastrointestinal Stromal Tumor

Sources:
54Reactome, 52QIAGEN, 4Cell Signaling Technology, 12EMD Millipore, 38NCBI BioSystems Database, 30KEGG, 50PharmGKB
See all sources

Pathways related to Gastrointestinal Stromal Tumor according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.8S100B, PDGFRB, PDGFRA, KITLG, KIT
2
Hide members
10.7KIT, KITLG, PDGFRA, PDGFRB, VIM
3
Hide members
10.7PDGFRB, PDGFRA, ETV1, KITLG, KIT
4
Hide members
10.7KIT, KITLG, PDGFRA, PDGFRB
510.7PDGFRB, PDGFRA, KITLG, KIT
6
Hide members
10.7PDGFRB, PDGFRA, KITLG, KIT
7
Hide members
10.7DES, PDGFRA, PDGFRB, VIM
810.7VIM, DES, NF2, ACTC1
9
Hide members
10.6SDHA, SDHC, SDHB
10
Hide members
10.6SDHA, SDHC, SDHB
11
Hide members
10.6SDHA, SDHC, SDHB
1210.6ACTC1, KIT, PDGFRA
13
Hide members
10.6PDGFRB, PDGFRA, KIT
1410.6NF2, PDGFRA, PDGFRB
15
Hide members
10.6VIM, DES, ACTC1
16
Hide members
10.6DES, NES, VIM
1710.6KIT, KITLG, CD34
1810.6KIT, KITLG, CD34
1910.6PDGFRB, PDGFRA

Compounds for genes affiliated with Gastrointestinal Stromal Tumor

Sources:
45Novoseek, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 50PharmGKB
See all sources

Compounds related to Gastrointestinal Stromal Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1tyrosine4511.7DES, NES, PDGFRA, PDGFRB, S100A1, S100B
2vegf4511.6NES, PDGFRA, PDGFRB, S100B, VIM, DES
3paraffin4511.6ACTC1, VIM, S100B, S100A1, PDGFRB, PDGFRA
4retinoic acid45 2412.6VIM, S100B, S100A1, PDGFRB, PDGFRA, NES
5progesterone45 60 29 11 2415.4VIM, S100B, S100A1, PDGFRB, NES, DES
6calcium45 50 11 2414.4S100B, S100A1, PDGFRB, PDGFRA, DES, ANO1
7iron45 2412.4VIM, S100B, S100A1, DES, KITLG, ACTC1
8testosterone45 60 11 2414.4VIM, S100B, PDGFRB, DES, ETV1, KITLG
9hematoxylin4511.3VIM, S100B, S100A1, DES, CD34, KIT
10imatinib45 50 1113.3S100B, PDGFRB, PDGFRA, DES, KITLG, KIT
11oxygen45 2412.3S100B, NES, DES, KITLG, SDHB, SDHC
12cysteine4511.3VIM, S100B, S100A1, PDGFRB, DES, NF2
13bromodeoxyuridine4511.2KITLG, DES, NES, PDGFRB, S100B, VIM
14toluidine4511.2VIM, S100A1, DES, KITLG, KIT
15reticulin4511.2VIM, S100B, DES, CD34, ACTC1
16rapamycin4511.2KIT, KITLG, NF2, PDGFRA, PDGFRB, VIM
17mucicarmine4511.2VIM, S100B, S100A1, DES, ACTC1
18b 7234511.2ACTC1, DES, S100A1, S100B, VIM
19biotin45 11 2413.1VIM, S100A1, DES, KITLG, ACTC1
20formaldehyde45 2412.1VIM, S100B, DES, KIT, ACTC1
21orcein4511.1VIM, S100B, DES, ACTC1
22s 1004511.1VIM, S100B, DES, ACTC1
23lactate4511.1VIM, S100B, DES, KITLG, KIT, SDHB
24ag-12964511.1PDGFRB, PDGFRA, KITLG, KIT
25thymidine45 2412.1S100B, PDGFRA, DES, CD34, KITLG, KIT
26glycogen45 2412.0KIT, ACTC1, SDHB
27UBIQUINONE-11111.0SDHA, SDHC, SDHB
28glucose4511.0SDHB, ACTC1, KITLG, PDGFRB
29agar4511.0VIM, PDGFRB, NF2, CD34, KITLG
30monochloroacetic acid4511.0KIT, KITLG, VIM
31acetylcholine45 50 29 11 2415.0S100A1, NES, SV2A
32pkc 4124511.0PDGFRB, PDGFRA, KIT
332-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol1111.0SDHB, SDHC, SDHA
34ganglioside4511.0VIM, PDGFRB, NES, DES
352-methoxyethanol4511.0VIM, S100A1, ACTC1
36su54164511.0PDGFRB, KITLG, KIT
37Pazopanib1111.0KIT, PDGFRA, PDGFRB
38methionine4510.9VIM, S100B, PDGFRB, DES, KIT
39fluorochrome4510.9KIT, CD34, VIM
40rhodamine 12345 5011.9KIT, KITLG, CD34
41creatinine4510.9KITLG, ACTC1, SDHB
42Regorafenib1110.9KIT, PDGFRA, PDGFRB
43sunitinib45 50 1112.8KIT, PDGFRA, PDGFRB
44succinic acid29 11 2412.8SDHB, SDHC, SDHA
45paclitaxel45 50 1112.7PDGFRB, S100B
46iron-sulfur4510.7SDHB, SDHC, SDHA
47ubiquinone4510.6SDHA, SDHC, SDHB
48actomyosin4510.6ACTC1, S100A1, VIM
49gold4510.5DES, SV2A
50Becaplermin1110.3PDGFRA, PDGFRB

GO Terms for genes affiliated with Gastrointestinal Stromal Tumor

Sources:
16Gene Ontology
See all sources

Cellular components related to Gastrointestinal Stromal Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573711.1DDX39A, PDGFRA, PDGFRB, S100B, TLX2, VIM
2mitochondrial respiratory chain complex IIGO:00574910.6SDHA, SDHC, SDHB
3intermediate filamentGO:00588210.6DES, NES, VIM
4intrinsic to plasma membraneGO:03122610.3PDGFRA, PDGFRB

Biological processes related to Gastrointestinal Stromal Tumor according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1phosphatidylinositol-mediated signalingGO:04801511.0PDGFRB, PDGFRA, KITLG, KIT
2positive regulation of phospholipase C activityGO:01086311.0KIT, PDGFRA, PDGFRB
3cardiac myofibril assemblyGO:05500311.0ACTC1, PDGFRA, PDGFRB
4cell chemotaxisGO:06032611.0PDGFRB, PDGFRA, KIT
5positive regulation of phosphatidylinositol 3-kinase activityGO:04355211.0KIT, PDGFRA, PDGFRB
6tricarboxylic acid cycleGO:00609911.0SDHA, SDHC, SDHB
7fibroblast growth factor receptor signaling pathwayGO:00854311.0KIT, KITLG, PDGFRA, PDGFRB
8muscle filament slidingGO:03004910.9VIM, DES, ACTC1
9Fc-epsilon receptor signaling pathwayGO:03809510.9KIT, KITLG, PDGFRA, PDGFRB
10positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathwayGO:03809110.9PDGFRA, PDGFRB
11positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406810.9PDGFRB, PDGFRA, KIT
12metanephric glomerular capillary formationGO:07227710.9PDGFRA, PDGFRB
13epidermal growth factor receptor signaling pathwayGO:00717310.9PDGFRB, PDGFRA, KITLG, KIT
14germ cell programmed cell deathGO:03523410.9KIT, KITLG
15peptidyl-tyrosine phosphorylationGO:01810810.8PDGFRB, PDGFRA, KIT
16hemopoiesisGO:03009710.8KIT, KITLG, CD34
17innate immune responseGO:04508710.8KIT, KITLG, PDGFRA, PDGFRB, S100B
18stem cell proliferationGO:07208910.7NES, CD34
19retina vasculature development in camera-type eyeGO:06129810.7PDGFRB, PDGFRA
20succinate metabolic processGO:00610510.6SDHA, SDHB
21respiratory electron transport chainGO:02290410.5SDHA, SDHC, SDHB
22neurotrophin TRK receptor signaling pathwayGO:04801110.4PDGFRB, PDGFRA, KITLG, KIT

Molecular functions related to Gastrointestinal Stromal Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.3VIM, S100B, S100A1, PDGFRB, PDGFRA, DDX39A
2succinate dehydrogenase (ubiquinone) activityGO:00817710.7SDHA, SDHB
3vascular endothelial growth factor bindingGO:03808510.6PDGFRB, PDGFRA
4platelet-derived growth factor receptor bindingGO:00516110.6PDGFRA, PDGFRB
5S100 protein bindingGO:04454810.5S100A1, S100B
6platelet-derived growth factor bindingGO:04840710.3PDGFRA, PDGFRB

Products for genes affiliated with Gastrointestinal Stromal Tumor

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gastrointestinal Stromal Tumor

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet