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MCID: GST019

Gastrointestinal Stromal Tumor malady
161 genes, 13 tissues, 826 related diseases, 29 phenotypes, 432 articles, clinical trials, genetic tests.

Summaries for Gastrointestinal Stromal Tumor

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30NIH Rare Diseases, 23MedlinePlus, 17Genetics Home Reference, 44Wikipedia, 22MalaCards
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MedlinePlus: Your small intestine is part of your digestive system. it is a long tube that connects your stomach to your large intestine. intestinal cancer is rare, but eating a high-fat diet or having crohn's disease, celiac disease, or a history of colonic polyps can increase your risk. abdominal pain or lumps, weight loss for no reason or blood in the stool can be symptoms. imaging tests that create pictures of the small intestine and the area around it can help diagnose intestinal cancer and show whether it has spread. surgery is the most common treatment. additional options include chemotherapy, radiation or a combination. nih: national cancer institute23

MalaCards: Gastrointestinal Stromal Tumor, also known as intestinal cancer, is related to neurofibromatosis and carney triad. An important gene associated with Gastrointestinal Stromal Tumor is KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog), and among its related pathways are Apoptosis and survival Role of CDK5 in neuronal death and survival and Colorectal cancer. The compounds glucose and roscovitine have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, small intestine and colon, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

NIH Rare Diseases: Gastrointestinal stromal tumors are a type of soft tissue sarcoma (tumor) that usually begins in cells in the wall of the stomach, intestines, or rectum. These tumors may be noncancerous or cancerous. They can affect adults, adolescents, or children.  It is estimated that around 5,000 new cases of gastrointestinal stromal tumors are diagnosed in the United States each year.30

Genetics Home Reference: A gastrointestinal stromal tumor (GIST) is a type of tumor that occurs in the gastrointestinal tract, most commonly in the stomach or small intestine. The tumors are thought to grow from specialized cells found in the gastrointestinal tract called interstitial cells of Cajal (ICCs) or precursors to these cells. GISTs are usually found in adults between ages 40 and 70 and can be cancerous (malignant) or noncancerous (benign).17

Wikipedia: A gastrointestinal stromal tumor (GIST) is one of the most common mesenchymal tumors of the...44 more...

Aliases & Descriptions for Gastrointestinal Stromal Tumor

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6Disease Ontology, 7diseasecard, 17Genetics Home Reference, 8DISEASES, 32Novoseek , 30NIH Rare Diseases, 16GeneTests, 43UMLS, 23MedlinePlus, 24MeSH, 40SNOMED-CT, 33OMIM, 27NCIt
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Aliases & Descriptions:

gastrointestinal stromal tumor 6 7 17 8 32
intestinal cancer 17 32 23 43
gist 6 30 16 17
gastrointestinal stromal tumors 30 16 43
stromal tumor of gastrointestinal tract 6
gastrointestinal stromal sarcoma 30
stromal neoplasm 43
gant 6

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Related Diseases for Gastrointestinal Stromal Tumor

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13GeneCards, 14GeneDecks
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Diseases related to gastrointestinal stromal tumor by text searches and GeneDecks gene sharing:

(show top 50)    (show all 823)
idRelated DiseaseScoreTop Affiliating Genes
1neurofibromatosis34.0SDHB, SDHD, CD44, EZR, AKT1, NF1
2carney triad32.9KIT, SDHA, SDHB, SDHC, SDHD, PDGFRA
3hyperinsulinemic hypoglycemia31.5PCNA, VIM, ENO2, IGF1R, IGF2, IGF1
4perineurioma31.3NCAM1, KIT, VIM, BRAF, S100B, CD34
5hypoglycemia31.1PIK3CG, PCNA, VIM, VEGFA, ENO2, CCND1
6paraganglioma31.0NCAM1, KIT, PCNA, VIM, BCL2, SDHA
7paraganglioma and gastric stromal sarcoma30.8SDHB, SDHC, SDHD
8sex cord-gonadal stromal tumor30.6VIM, S100B, WT1, DES, PGR
9mastocytosis30.2PIK3CA, PIK3R1, KIT, KITLG, VIM, BCL2
10neurofibroma30.1KIT, KITLG, VIM, VEGFA, VCAN, S100A1
11endometrial stromal tumor29.3VIM, CCND1, CTNNB1, DES
12fibromatosis29.2KIT, PCNA, VIM, S100A1, CDKN2A, CD34
13leiomyosarcoma28.7KIT, PCNA, VIM, VEGFA, BCL2, MUC16
14vasculitis28.7VEGFA, S100A1, MMP9, ANGPT2, ANXA5, IFNA1
15multiple endocrine neoplasia28.0SDHB, SDHC, SDHD, CDKN1A, CDKN2B, CDKN2A
16smooth muscle tumor27.5KIT, PCNA, VIM, VEGFA, BCL2, S100A1
17duodenitis26.8PIK3CG, KIT, KITLG, PCNA, BRAF, BCL2
18leiomyoma25.3PIK3R1, KIT, PCNA, VIM, VEGFA, VCAN
19gallbladder carcinoma21.5PIK3CA, NCAM1, PCNA, SERPINB5, VEGFA, BCL2
20pheochromocytoma21.5NCAM1, KIT, VEGFA, RAF1, BCL2, SDHA
21polyposis20.9PIK3CG, KITLG, PCNA, VIM, BRAF, VEGFA
22peritonitis19.9KIT, KITLG, PCNA, VIM, VEGFA, VCAN
23esophagitis19.3PIK3CA, PIK3CG, KLF5, NCAM1, KIT, KITLG
24hypoxia18.7PIK3CA, PIK3R1, PIK3CG, KLF5, KIT, KITLG
25pancreatitis18.3PIK3CA, PIK3R1, PIK3CG, KLF5, NCAM1, KIT
26thyroid cancer17.8PIK3CA, PIK3R1, PIK3CG, KIT, PCNA, SERPINB5
27adenocarcinoma17.8PIK3CA, PIK3R1, PIK3CG, NCAM1, KIT, KITLG
28leukemia17.4PIK3CA, PIK3R1, PIK3CG, KLF5, NCAM1, NCR3
29prostatitis17.1PIK3CA, PIK3R1, PIK3CG, KLF5, NCAM1, KIT
30sarcoma17.0PIK3CA, PIK3R1, PIK3CG, NCAM1, KIT, KITLG
31myeloid leukemia17.0PIK3CA, PIK3R1, PIK3CG, KLF5, NCAM1, NCR3
32adenoma16.9PIK3CA, NCAM1, KIT, KITLG, PCNA, SERPINB5
33thyroiditis16.2PIK3CA, PIK3R1, PIK3CG, NCAM1, KIT, KITLG
34hepatitis15.9PIK3CA, PIK3R1, PIK3CG, NCAM1, NCR3, KIT
35carcinoma15.5PIK3CA, PIK3R1, PIK3CG, KLF5, NCAM1, NCR3
36polymorphous low-grade adenocarcinoma14.4KIT, PCNA, SERPINB5, VIM, S100A1, S100B
37perivascular epithelioid cell tumor14.4KIT, KITLG, VIM, S100A1, S100B, CDKN2A
38cutaneous fibrous histiocytoma14.3KITLG, S100A1, S100B, CD34, ACTC1, DES
39glomus tumor14.3VIM, SDHB, SDHD, S100A1, S100B, CDKN2B
40cutaneous leiomyosarcoma14.3KIT, VIM, S100B, ACTC1, DES
41spindle cell lipoma14.3VIM, S100A1, CD34, ACTC1, DES
42chondroma14.3KIT, SDHA, SDHB, SDHC, SDHD, S100A1
43ossifying fibromyxoid tumor14.3VIM, S100A1, S100B, ACTC1, DES
44spindle cell sarcoma14.3VIM, S100B, NTRK3, ACTC1, DES
45fibrous histiocytoma14.2VIM, S100B, CD34, ACTC1, DES
46ossifying fibroma14.2VIM, MUC16, S100A1, CD34, ACTC1, DES
47pulmonary vein stenosis14.2MKI67, PDGFRA, ACTC1, DES, PECAM1
48congenital epulis14.2VIM, S100B, ENO2, DES
49salivary adenoma14.2KITLG, VIM, S100B, PLAG1
50epulis14.1VIM, S100B, ENO2, DES

Graphical network of the top 20 diseases related to gastrointestinal stromal tumor:



Graphical network of diseases related to gastrointestinal stromal tumor

Clinical Features for Gastrointestinal Stromal Tumor

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Drugs & Therapeutics for Gastrointestinal Stromal Tumor

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for gastrointestinal stromal tumor

Search NIH Clinical Center for gastrointestinal stromal tumor

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Genetic Tests for Gastrointestinal Stromal Tumor

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16GeneTests
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Genetic tests related to gastrointestinal stromal tumor:

id Genetic test Affiliating Genes
1 Gastrointestinal Stromal Tumor
clinical/research 		KIT, PDGFRA

Anatomical Context for Gastrointestinal Stromal Tumor

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22MalaCards
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MalaCards organs/tissues related to gastrointestinal stromal tumor:

22
Smooth muscle, Small intestine, Colon, Liver, Thyroid, Ovary, Uterus, Prostate, Myeloid, T cells, B cells, Endothelial, Appendix

Phenotypes for genes affiliated with Gastrointestinal Stromal Tumor

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25MGI
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MGI Mouse Phenotypes related to gastrointestinal stromal tumor:

25 (show all 29)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1respiratory system phenotypeMP:000538810.8KLF5, NF1, NF2, TIE1, PRKCQ, MYH11
2endocrine/exocrine gland phenotypeMP:000537910.2KLF5, CDKN2B, FGFR1, AMPH, CASP2, CASP8
3craniofacial phenotypeMP:00053829.9KIT, KITLG, L1CAM, GRB2, IGF1R, CASP9
4hematopoietic system phenotypeMP:00053979.8KIT, PCNA, BRAF, BCL2, BCL2L11, MSH2
5other phenotypeMP:00053959.2JAK2, CDKN2A, ITGA6, TP73, PTGS2, SPP1
6liver/biliary system phenotypeMP:00053709.2KIT, VEGFA, MTAP, MDK, AKT1, TP53
7pigmentation phenotypeMP:00011868.9KIT, KITLG, BRAF, BCL2, BCL2L11, L1CAM
8renal/urinary system phenotypeMP:00053678.5KIT, BRAF, BCL2, BCL2L11, BCR, BAX
9hearing/vestibular/ear phenotypeMP:00053778.0KIT, KITLG, BCL2, BCL2L11, BCR, BAX
10immune system phenotypeMP:00053878.0KLF5, KIT, VIM, BRAF, RAF1, BCL2L11
11behavior/neurological phenotypeMP:00053868.0PIK3CA, NCAM1, KIT, VIM, BRAF, BCR
12embryogenesis phenotypeMP:00053807.7PIK3CA, KLF5, KIT, SERPINB5, VIM, BRAF
13limbs/digits/tail phenotypeMP:00053717.5KIT, KITLG, VEGFA, VCAN, BCL2L11, BAX
14nervous system phenotypeMP:00036317.5KIT, KITLG, BRAF, VCAN, RAF1, BCL2L11
15reproductive system phenotypeMP:00053897.4PIK3CA, VEGFA, L1CAM, CDKN2B, CD44, CDH1
16normal phenotypeMP:00028737.4PIK3R1, KLF5, BRAF, VEGFA, VCAN, BCL2L11
17no phenotypic analysisMP:00030127.4PIK3R1, PCNA, VEGFA, L1CAM, CD44, CDH1
18adipose tissue phenotypeMP:00053757.0PIK3CA, PIK3R1, BRAF, BCL2, CDKN1A, MCM2
19mortality/agingMP:00107686.9PIK3CA, KLF5, NCAM1, KITLG, SERPINB5, BRAF
20integument phenotypeMP:00107716.7PIK3CG, KIT, KITLG, BRAF, RAF1, BCL2
21vision/eye phenotypeMP:00053916.5PIK3CA, NCAM1, KIT, KITLG, VIM, BRAF
22digestive/alimentary phenotypeMP:00053815.9KLF5, KIT, KITLG, BRAF, VEGFA, BCL2
23growth/size phenotypeMP:00053784.8PIK3CA, PIK3R1, PIK3CG, KLF5, KIT, KITLG
24skeleton phenotypeMP:00053904.7PIK3CG, KIT, KITLG, BRAF, VEGFA, VCAN
25muscle phenotypeMP:00053694.2PIK3CA, PIK3R1, PIK3CG, KLF5, KIT, VIM
26tumorigenesisMP:00020064.0PIK3CA, PIK3R1, KIT, KITLG, BRAF, BCL2
27cardiovascular system phenotypeMP:00053852.9PIK3CA, PIK3R1, PIK3CG, KLF5, KIT, KITLG
28cellular phenotypeMP:00053841.9PIK3CA, PIK3R1, PIK3CG, KLF5, NCAM1, KIT
29homeostasis/metabolism phenotypeMP:00053761.2PIK3CA, PIK3R1, PIK3CG, KLF5, KIT, KITLG

Publications for genes affiliated with Gastrointestinal Stromal Tumor

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35PubMed
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Articles related to gastrointestinal stromal tumor:

(show top 50)    (show all 432)
idTitleAuthorsYearAffiliating Genes
1DOG1 and PKC-I, are useful in the diagnosis of KIT-neg ative gastrointestinal stromal tumors. (21358619)Kang G.H.... Kim K.M.2011PRKCQ, ANO1
2KIT-negative gastrointestinal stromal tumor of the ab dominal soft tissue: a clinicopathologic and genetic study of 10 cases. (21836495)Yamamoto H.... Oda Y.2011KIT
3Gastrointestinal stromal tumors: a paradigm for thera peutic options in solid organ tumors. (20500152)Novak C.... Trevino J.G.2010PDGFRB, VEGFA
4Role for the proapoptotic factor BIM in mediating ima tinib-induced apoptosis in a c-KIT-dependent gastrointestinal stromal tumor cel l line. (20231287)Gordon P.M.... Fisher D.E.2010KIT, BCL2L11
5Disappearance of lentigines in a patient receiving im atinib treatment for familial gastrointestinal stromal tumor syndrome. (19917964)Campbell T.... Moore J.2009NTRK3
6Residual and recurrent gastrointestinal stromal tumor s with KIT mutations: findings at first follow-up CT after imatinib treatment. (19620409)Choi D.... Chang I.2009KIT
7Up-regulated expression of ADAM17 in gastrointestinal stromal tumors: coexpression with EGFR and EGFR ligands. (19298600)Nakagawa M.... Iwasaki H.2009ADAM17, ADAM9, AREG
8Circulating levels of soluble KIT serve as a biomarke r for clinical outcome in gastrointestinal stromal tumor patients receiving sun itinib following imatinib failure. (19737953)Deprimo S.E.... Demetri G.D.2009KIT
9Gastrointestinal stromal tumor: a bridge between benc h and bedside. (20047122)Nishida T.... Miyazaki Y.2009PDGFRA
10Gastrointestinal stromal tumors: past, present, and f uture. (18648736)Kitamura Y.2008KIT
11The insulin-like growth factor system as a potential therapeutic target in gastrointestinal stromal tumors. (18818517)Belinsky M.G.... Godwin A.K.2008PDGFRA
12A 17 year-old man with an exon 11 mutation of CD-117 causing a gastrointestinal stromal tumor. (18259950)Bauer T.M.... Berlin J.D.2008KIT
13Genetic aberrations of gastrointestinal stromal tumors. (18671247)Yang J.... Zhang W.2008PDGFRA, KIT
14Novel V600E BRAF mutations in imatinib-naive and imatinib-resistant gastrointestinal stromal tumors. (18615679)Agaram N.P.... Antonescu C.R.2008PDGFRA, KIT, BRAF
15Expression of stem cell factor (SCF), a KIT ligand, in gastrointestinal stromal tumors (GISTs): a potential marker for tumor proliferation. (18602222)Hirano K.... Kamma H.2008KIT, KITLG
16Gastrointestinal Stromal Tumors (GIST) and Their Management. (19360154)Maki R.G.2007KIT
17Association of intratumoral vascular endothelial growth factor expression and clinical outcome for patients with gastrointestinal stromal tumors treated with imatinib mesylate. (18006774)McAuliffe J.C.... Trent J.C.2007VEGFA
18A review of resistance patterns and phenotypic changes in gastrointestinal stromal tumors following imatinib mesylate therapy. (17417711)Bickenbach K.... Roggin K.K.2007KIT
19Sorafenib inhibits the imatinib-resistant KITT670I ga tekeeper mutation in gastrointestinal stromal tumor. (17699867)Guo T.... Antonescu C.R.2007KIT
20Genetics of carney triad: recurrent losses at chromosome 1 but lack of germline mutations in genes associated with paragangliomas and gastrointestinal stromal tumors. (17535989)Matyakhina L.... Stratakis C.A.2007SDHB, SDHC, SDHD
21Diagnostic morphological features of PDGFRA-mutated gastrointestinal stromal tumors: molecular genetic and histologic analysis of 60 cases of gastric gastrointestinal stromal tumors. (17240304)Daum O.... Michal M.2007KIT
22Effect of loss of heterozygosity of the c-kit gene on prognosis after hepatectomy for metastatic liver gastrointestinal stromal tumors. (17894554)Kikuchi H.... Konno H.2007KIT
23Pediatric KIT wild-type and platelet-derived growth factor receptor alpha-wild-type gastrointestinal stromal tumors share KIT activation but not mechanisms of genetic progression with adult gastrointestinal stromal tumors. (17909012)Janeway K.A.... Fletcher J.A.2007PDGFRA, KIT
24Expression of alpha6 integrin subunit is associated with malignancy in gastric gastrointestinal stromal tumors. (17261983)Takeyama H.... Manabe T.2007ITGA6
25Highly accurate two-gene classifier for differentiating gastrointestinal stromal tumors and leiomyosarcomas. (17360660)Price N.D.... Zhang W.2007OBSCN, PRUNE2
26Prognostic value of P16 gene methylation and P16 protein expression in gastrointestinal stromal tumor (17659467)Liang J.F.... Wang H.K.2007CDKN2A
27Differentially expressed proteins in gastrointestinal stromal tumors with KIT and PDGFRA mutations. (16402362)Kang H.J.... Kim H.2006PDGFRA, KIT, ANXA5
28Imatinib in gastrointestinal stromal tumor treatment--results from University Hospital Centre Zagreb (16910417)Vrbanec D.... JakiA8-RazumoviA8 J.2006PDGFRA
29Early effects of imatinib mesylate on the expression of insulin-like growth factor binding protein-3 and positron emission tomography in patients with gastrointestinal stromal tumor. (16986125)Trent J.C.... Zhang W.2006IGFBP3
30Status and clinical implication of c-kit and PDGFRA mutations in 165 cases of gastrointestinal stromal tumor (GIST) (16776995)He H.Y.... Wu B.Q.2006PDGFRA
31Ultrastructural features and platelet-derived growth factor receptor A gene mutations in CD117-negative gastrointestinal stromal tumor (16630479)Xiang Y.N.... Zheng J.2006PDGFRA, KIT
32PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib. (15928335)Corless C.L.... Heinrich M.C.2005PDGFRA
33Expression and clinical significance of p27 protein and cyclinD1 protein in gastrointestinal stromal tumors (16029637)Yang X.D.... Pan K.2005IFI27
34Gastrointestinal stromal tumor (GIST) in southern Taiwan: a clinicopathologic study of 93 resected cases. (15807305)Li C.F.... Lin C.N.2005ACTC1, S100A1
35Relationship between expression of cyclin D1, Ki-67 and bcl-2 and biologic behavior in CD117-positive gastrointestinal stromal tumors (16545187)Sun M.... Li D.F.2005BCL2
36Prognostic value of KIT mutation in gastrointestinal stromal tumors. (15991300)Liu X.H.... Ma D.L.2005KIT
37Prognostic role of E2F1 and members of the CDKN2A network in gastrointestinal stromal tumors. (16166437)Haller F.... FA1zesi L.2005E2F1
38Gastrointestinal stromal tumors (GISTs): clinical an d pathological features (16052979)KovA!cs M.... FehAcr J.2005PRKCQ
39Effects of imatinib vary with the types of KIT-mutation in gastrointestinal stromal tumor cell lines. (16077968)Noma K.... Tanaka N.2005KIT, FAM215A
40Novel germline mutation of KIT associated with familial gastrointestinal stromal tumors and mastocytosis. (16143141)Hartmann K.... Longley B.J.2005KIT
41Gastrointestinal stromal tumor presenting as a pelvic mass. (14675690)Zighelboim I.... Edwards C.2003ACTC1
42KIT 1530ins6 mutation defines a subset of predominantly malignant gastrointestinal stromal tumors of intestinal origin. (14691917)Lasota J.... Miettinen M.2003KITLG
43Gastrointestinal stromal tumors in a mouse model by targeted mutation of the Kit receptor tyrosine kinase. (12754375)Sommer G.... Besmer P.2003KIT
44Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors. gastrointestinal stromal tumors. (12072198)Sandberg A.A.... Bridge J.A.2002KIT
45Expression and mutation of c-kit gene in gastrointestinal stromal tumor (12485499)Ma D.... Xie Q.2002KIT
46Mutations in c-kit gene exons 9 and 13 in gastrointestinal stromal tumors among Japanese. (11376557)Sakurai S.... Saito K.2001KIT
47Gastrointestinal stromal tumor with skeinoid fibers of the ileum. (11002369)Hirokawa M.... Sano T.2000S100A1
48Embryonic form of smooth muscle myosin heavy chain (SMemb/MHC-B) in gastrointestinal stromal tumor and interstitial cells of Cajal. (9916914)Sakurai S.... Fukayama M.1999MYH11
49Gastrointestinal stromal tumors--value of CD34 antigen in their identification and separation from true leiomyomas and schwannomas. (7530409)Miettinen M.... Maarit-Sarlomo-Rikala .1995CD34, PECAM1
50Gastrointestinal stromal tumor (GIST): morphologic a nd immunohistochemical study of 10 cases (1843094)Hirata L.... Schmitt F.C.1991S100A1

Expression for genes affiliated with Gastrointestinal Stromal Tumor

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Gastrointestinal Stromal Tumor

Pathways for genes affiliated with Gastrointestinal Stromal Tumor

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10EMD Millipore, 20KEGG, 34PharmGKB, 36QIAGEN, 41Thomson Reuters
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Pathways related to gastrointestinal stromal tumor according to GeneDecks:

(show top 50)    (show all 374)
idPathwayScoreTop Affiliating Genes
1Apoptosis and survival Role of CDK5 in neuronal death and survival1010.6BCL2, CASP9
2Colorectal cancer2010.3PIK3R1, PIK3CG, BRAF, MSH2, CASP9
3Sorafenib Pharmacodynamics349.7PIK3CA, PIK3R1, BRAF, RAF1, FLT3, MAPK1
4Akt Signaling369.5PIK3R1, PIK3CG, KIT, RAF1, ITGA6, FLT3
5Acute myeloid leukemia209.3PIK3CA, PIK3R1, PIK3CG, KIT, BRAF, RAF1
6Signal transduction_AKT signaling419.2PIK3CA, PIK3R1, PCNA, BCL2L11, BAX, CDKN1A
7Apoptosis and survival_Caspase cascade419.2BAX, IGF1R, IGF1, CASP7, CASP10, CASP3
814-3-3 Induced Apoptosis369.1PIK3R1, BCL2, MAPK10, MAPK1, CASP7, CASP10
9ErbB2-ErbB3 Heterodimers369.1PIK3R1, RAF1, GRB2, ERBB2, RPS6KB1, STAT1
10Telomerase Components in Cell Signaling369.0KIT, KITLG, AREG, FGFR1, MDK, IGF1R
11Apoptotic Pathways in Synovial Fibroblasts368.9PIK3R1, KIT, KITLG, AREG, FGFR1, MDK
12Apoptosis and survival Caspase cascade108.9BAX, IGF1R, IGF1, CASP7, CASP10, CASP3
13JNK Pathway368.9PIK3R1, KIT, KITLG, RAF1, BCL2, BAX
14p53 signaling pathway208.8SERPINB5, BAX, CDKN1A, CDKN2A, CCND3, CCND1
15p53 Signaling368.7BCL2, BAX, CDKN1A, MAPK10, CASP10, CASP3
16Antioxidant Action of Vitamin-C368.7KIT, KITLG, BCL2, BAX, JAK2, AREG
17Transcription Receptor-mediated HIF regulation108.7PIK3R1, RAF1, GRB2, MAPK1, IGF1R, IGFBP3
18DHA Signaling368.5PIK3R1, KIT, KITLG, BCL2, BAX, AREG
19Paxillin Interactions368.4PIK3R1, KIT, KITLG, ITGA6, FLT3, AREG
20Non-small cell lung cancer208.3PIK3CA, PIK3R1, PIK3CG, BRAF, RAF1, CDKN2A
21Signal transduction PTEN pathway108.3PIK3CA, PIK3R1, PCNA, RAF1, CDKN1A, GRB2
22PTEN Pathway368.3PIK3R1, KIT, KITLG, BRAF, ITGA6, AREG
23eIF2 Pathway368.2PIK3R1, KIT, KITLG, BRAF, RAF1, AREG
24PPAR Pathway368.2PIK3R1, KIT, KITLG, RAF1, ITGA6, AREG
25Development IGF-RI signaling108.2PIK3CA, PIK3R1, RAF1, GRB2, MAPK1, CCND3
26Development_IGF-1 receptor signaling418.2PIK3CA, PIK3R1, RAF1, GRB2, MAPK1, CCND3
27Mitochondrial Apoptosis368.2PIK3R1, KIT, KITLG, BCL2, BCL2L11, BAX
2814-3-3 Induced Intracellular Signaling368.1PIK3R1, KITLG, RAF1, FLT3, AREG, GRB2
29PAK Pathway368.1PIK3R1, KIT, KITLG, BCL2, BAX, AREG
30eNOS Signaling368.1PIK3R1, KIT, KITLG, FLT3, AREG, FGFR1
31Glioblastoma Multiforme367.9PIK3R1, BRAF, RAF1, CDKN1A, GRB2, MAPK1
32GSK3 Signaling367.9PIK3R1, KIT, KITLG, CDH1, FLT3, AREG
33Apoptosis and survival_Role of CDK5 in neuronal death and survival417.9PIK3CA, PIK3R1, RAF1, BCL2, BAX, MAPK10
34Colorectal Cancer Metastasis367.8PIK3R1, BRAF, BAX, MSH2, CDKN1A, CDH1
35Ras Pathway367.7PIK3R1, KIT, BRAF, RAF1, ITGA6, FLT3
36NFAT in Immune Response367.7PIK3R1, KIT, KITLG, FLT3, AREG, FGFR1
37Endothelin-1 Signaling Pathway367.6PIK3R1, KIT, BRAF, RAF1, FLT3, GRB2
38p38 Signaling367.6KIT, KITLG, BCL2, BAX, FLT3, AREG
39Nanog in Mammalian ESC Pluripotency367.5KIT, KITLG, BRAF, RAF1, FLT3, AREG
40Bladder cancer207.4BRAF, VEGFA, RAF1, CDKN1A, CDKN2A, CDH1
41Development_EGFR signaling pathway417.4PIK3CA, PIK3R1, RAF1, JAK2, MMP9, AREG
42Renin-Angiotensin Pathway367.4PIK3R1, KIT, KITLG, RAF1, JAK2, AREG
43ErbB signaling pathway207.3PIK3CA, PIK3R1, PIK3CG, BRAF, RAF1, CDKN1A
44EGF Pathway367.3PIK3R1, BRAF, RAF1, JAK2, CDH1, GRB2
45ILK Signaling367.2PIK3R1, KIT, KITLG, VIM, CDH1, FLT3
46Rho Family GTPases367.1PIK3R1, KIT, KITLG, VIM, RAF1, BCL2
47GPCR Pathway367.1PIK3R1, KIT, KITLG, BRAF, RAF1, FLT3
48Focal adhesion206.9PIK3CA, PIK3R1, PIK3CG, BRAF, RAF1, BCL2
49JAK-STAT Pathway366.8PIK3R1, KIT, KITLG, RAF1, BCL2, BAX
50Pathways in cancer205.1PIK3CA, PIK3R1, PIK3CG, VEGFA, BCL2, BCR

Compounds for genes affiliated with Gastrointestinal Stromal Tumor

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32Novoseek , 42Tocris Bioscience, 9DrugBank, 18HMDB, 34PharmGKB
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Compounds related to gastrointestinal stromal tumor according to GeneDecks:

(show top 50)    (show all 402)
idCompoundScoreTop Affiliating Genes
1glucose32 10.7KIT, BRAF, VCAN, MUC16, S100B, MKI67
2roscovitine32 10.5PIK3CG, PCNA, VIM, MCL1, IFI27, CASP8
3ac-lehd-afc42 10.2CASP7, CASP10, CASP4, CASP6, CASP2, CASP14
4sp 60012532 42 10.9PIK3CG, CDKN1A, CASP3, AKT1, TP53
5c2ceramide32 9.9PIK3CG, BAX, CASP3, CASP8, AKT1, PTK2
6lovastatin32 42 9 9 12.7RAF1, CDKN1A, CDKN2A, ANXA5, CCND1, IGF1R
7hoechst 3334232 9.7KITLG, PCNA, BCL2, BAX, CDKN1A, ANXA5
8ascorbic acid32 18 10.6PIK3CG, PCNA, RAF1, SDHB, S100B, JAK2
9rosiglitazone32 9 18 9 12.4PIK3CA, PIK3CG, JAK2, CDKN1A, MMP9, MAPK1
10estradiol32 9 18 9 12.4KITLG, PCNA, VIM, MKI67, AREG, GRB2
11tgf beta132 9.3KITLG, VIM, VCAN, CDKN1A, CDKN2B, CDH1
12gnrh32 9.3NCAM1, KITLG, VIM, RAF1, MKI67, FGFR1
13nitric oxide32 9 18 9 12.2NCAM1, KIT, KITLG, SERPINB5, BCL2L11, S100A1
14biotin32 9 18 9 12.2KITLG, PCNA, VIM, S100A1, MSH2, CDKN2A
15ribonucleic acid32 9.1KIT, KITLG, CD9, MMP9, FGFR1, ENO2
16dutp32 9.0PCNA, BCL2, BAX, MKI67, ANXA5, CCND1
174-hydroxytamoxifen32 8.9S100B, AREG, MAPK1, IGF1, HSP90AA1, HMGB1
18creatinine32 8.8NCAM1, KITLG, PCNA, SDHB, MUC16, S100B
19calcitriol32 42 9 18 9 12.8KITLG, CDKN1A, CD44, CDH1, AREG, IGF1R
20ceramide32 8.7PIK3CA, PIK3R1, RAF1, BCL2L11, JAK2, MCL1
21glycogen32 18 9.7PIK3CA, PIK3R1, PIK3CG, KIT, VIM, SDHB
22superoxide32 18 9.7PIK3CA, PIK3R1, KITLG, SDHB, SDHC, MLH1
23atp32 8.6PIK3CA, NCAM1, KIT, BRAF, BCR, SDHB
24noxa32 8.4BCL2, BCL2L11, BAX, CDKN1A, MCL1, ANXA5
25silymarin32 8.4PCNA, VEGFA, MMP9, MAPK1, CCND3, CCND1
26cytochalasin d32 42 9.4PIK3CG, KITLG, VIM, RAF1, BCR, JAK2
27mitoxantrone32 9 9 10.4BCL2, FLT3, ANXA5, IGF1R, IFNA1, CASP3
28troglitazone32 42 9 9 11.3PIK3CG, BCL2, BAX, CDKN1A, CDH1, MMP9
29calcium32 9 18 9 11.3KIT, KITLG, BRAF, BCR, SDHB, S100A1
30camptothecin32 42 9 9 11.2PIK3CG, PCNA, BCL2, BAX, CDKN1A, CDKN2A
31proline32 8.1PIK3R1, KLF5, VIM, S100B, MSH2, JAK2
32cholesterol32 9 18 9 10.9PIK3CA, PIK3R1, KITLG, BCR, SDHB, SDHC
33agar32 7.8PIK3CA, PIK3R1, KITLG, VIM, BRAF, MTAP
34adpribose32 7.7PIK3CA, PIK3CG, PCNA, BCL2, BAX, CDKN1A
35n-(4-hydroxyphenyl)retinamide32 7.6VIM, BCL2, BAX, CDKN1A, ANXA5, CCND1
36matrigel32 7.6PIK3CA, PIK3R1, PIK3CG, NCAM1, SERPINB5, VIM
37tetracycline32 9 9 9.6CDKN2A, MMP9, ANGPT1, IFI27, ALB, CASP1
38oxygen32 18 8.5KITLG, BCL2, BCL2L11, BCR, SDHA, SDHB
39cysteine32 7.2PCNA, RAF1, SDHB, S100A1, S100B, CDKN2A
40phosphotyrosine32 6.9PIK3CA, PIK3R1, PIK3CG, KIT, RAF1, BCR
41adriamycin32 6.3VIM, BCL2, BAX, CDKN1A, CDKN2A, CD44
42arsenite32 18 7.3PIK3CA, PIK3R1, PIK3CG, PCNA, VEGFA, BCL2
43thymidine32 18 7.2PIK3CA, PIK3R1, KIT, KITLG, PCNA, RAF1
44alanine32 6.2KLF5, NCAM1, KITLG, PCNA, BRAF, RAF1
45docetaxel32 34 9 9 8.6KIT, VEGFA, RAF1, BCL2, BAX, CDKN1A
46paraffin32 5.2NCAM1, KIT, KITLG, PCNA, SERPINB5, VIM
47pd 98,05932 5.0PIK3CA, PIK3R1, PIK3CG, KIT, KITLG, BRAF
48curcumin32 4.9PIK3CG, VEGFA, RAF1, BCL2, BCL2L11, BAX
49tamoxifen32 34 9 9 7.6PIK3CA, PCNA, SERPINB5, VIM, VEGFA, RAF1
50testosterone32 9 18 9 7.4PIK3CA, PIK3R1, NCAM1, KIT, KITLG, PCNA

GO Terms for genes affiliated with Gastrointestinal Stromal Tumor

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Sources:
12Gene Ontology
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Cellular components related to gastrointestinal stromal tumor according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial respiratory chain complex IIGO:00574910.2SDHD, SDHC, SDHB, SDHA
2mitochondrial outer membraneGO:0057419.6CASP8, IFI27, MCL1, BAX, BCL2L11, BCL2
3cell surfaceGO:0099869.5PDGFA, ABCB1, HBEGF, CSF1R, ADAM17, ADAM9
4extracellular spaceGO:0056157.9SPP1, HMGB1, GHRL, ALB, PDGFA, EGFR
5nucleoplasmGO:0056547.8TERT, SMARCB1, RPS27A, WT1, HIF1A, TCF3
6plasma membraneGO:0058866.2RPS27A, RPSA, NRAS, CTNNB1, PTEN, TEK
7cytoplasmGO:0057376.1RPSA, NF1, NF2, PDGFRA, PDGFRB, WT1
8cytosolGO:0058296.0MYH11, RPS27A, RPSA, RPS6KB1, CTNNB1, PTK2
9nucleusGO:0056344.4PLAG1, RPS6KB1, RPSA, NF1, NF2, PDGFRA

Biological processes related to gastrointestinal stromal tumor according to GeneDecks:

(show top 50)    (show all 80)
idNameGO IDScoreTop Affiliating Genes
1peptidyl-tyrosine phosphorylationGO:01810810.5PDGFRA, PDGFRB, ABL1, CSF1R, PTK2, TEK
2positive regulation of phosphatidylinositol 3-kinase activityGO:04355210.5PDGFRB, PDGFRA, PTK2, TEK, FLT3, KIT
3hemopoiesisGO:03009710.4CSF1, ANGPT1, FLT3, CD34, KITLG, KIT
4G1 phase of mitotic cell cycleGO:00008010.3E2F1, CDKN1A, CDKN2B, CDKN2A, CCND1, RPS27A
5positive regulation of neuron apoptotic processGO:04352510.3NF1, CASP9, CASP2, CASP6, CASP3, CASP7
6activation of MAPKK activityGO:00018610.2RAF1, JAK2, NRAS, ADAM9
7positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406810.1PTK2, PDGFA, PDGFRA, PDGFRB, TEK, IGF1
8response to tumor necrosis factorGO:03461210.0ADAM9, RPS6KB1, CASP8, CASP3, MMP9, JAK2
9cellular component disassembly involved in apoptotic processGO:00692110.0PRKCQ, CTNNB1, PTK2, HMGB1, CASP8, CASP6
10response to organic cyclic compoundGO:01407010.0PRKCQ, STAT3, RPS6KB1, PTGS2, CASP1, CCND1
11macrophage differentiationGO:0302259.9CSF1R, CSF1, CASP8, MMP9, VEGFA
12induction of apoptosis by extracellular signalsGO:0086249.9OBSCN, RPS27A, CASP8, CASP2, CASP3, CASP10
13leukocyte migrationGO:0509009.8PECAM1, NRAS, TEK, ANGPT4, ANGPT1, ANGPT2
14induction of apoptosisGO:0069179.8CASP1, ETS1, PTEN, WT1, STAT1, CASP6
15positive regulation of smooth muscle cell proliferationGO:0486619.7PTGS2, RPS6KB1, PDGFRB, HBEGF, HIF1A, STAT1
16angiogenesisGO:0015259.6TEK, PTEN, PTK2, PDGFA, HIF1A, TIE1
17G1/S transition of mitotic cell cycleGO:0000829.6E2F1, PSMD9, RPS27A, RPS6KB1, CCND1, MCM2
18positive regulation of MAP kinase activityGO:0434069.6EGFR, PDGFRB, PDGFA, ERBB2, FGFR1, FLT3
19release of cytochrome c from mitochondriaGO:0018369.5TP73, TP53, CASP3, CASP7, BAX, BCL2
20positive regulation of peptidyl-serine phosphorylationGO:0331389.5TEK, AKT1, ANGPT1, CD44, BCL2, RAF1
21positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.5TP53, IGF1, IGF2, ANGPT4, ANGPT1, CD44
22positive regulation of cell migrationGO:0303359.5EGFR, ABCC1, HBEGF, CSF1, CSF1R, ADAM17
23response to hypoxiaGO:0016669.4ADAM17, PRKCQ, HIF1A, NF1, ETS1, CASP1
24response to estradiol stimulusGO:0323559.4STAT3, CTNNB1, PTGS2, ESR1, ETS1, CASP8
25induction of apoptosis by intracellular signalsGO:0086299.4TP53, AKT1, CASP9, CASP8, CASP3, CASP7
26heart developmentGO:0075079.4WT1, NF1, PTEN, TEK, ERBB2, CASP8
27positive regulation of protein kinase B signaling cascadeGO:0518979.4HBEGF, EGFR, PDGFA, PTK2, TEK, IGF1
28positive regulation of apoptotic processGO:0430659.4HMGB1, TP53, PTGS2, CTNNB1, NF1, ABL1
29positive regulation of protein phosphorylationGO:0019349.3ADAM17, CSF1R, PTK2, TEK, ERBB2, AKT1
30positive regulation of nitric oxide biosynthetic processGO:0454299.2EGFR, PTGS2, ESR1, AKT1, HSP90AB1, HSP90AA1
31positive regulation of transcription, DNA-dependentGO:0458939.2WT1, HIF1A, TCF3, STAT3, STAT1, PSMD9
32positive regulation of cell proliferationGO:0082849.1PTK2, NRAS, PDGFA, PDGFRA, PDGFRB, EGFR
33anti-apoptosisGO:0069169.1ETS1, AKT1, GHRL, TEK, TERT, RPS27A
34response to drugGO:0424939.1ABCB1, ABCC1, ABCG2, ACTC1, STAT3, NME1
35phosphatidylinositol-mediated signalingGO:0480159.0IGF1R, IGF1, CA8, CASP9, AKT1, ERBB2
36protein autophosphorylationGO:0467779.0CSF1R, EGFR, PDGFRB, PDGFRA, PTK2, TEK
37cell proliferationGO:0082838.9PTEN, EGFR, STAT3, CSF1, CSF1R, HDGF
38fibroblast growth factor receptor signaling pathwayGO:0085438.9CASP9, AKT1, PTEN, NRAS, RPS27A, MAPK1
39nerve growth factor receptor signaling pathwayGO:0480118.8AKT1, PTEN, NRAS, RPS27A, STAT3, OBSCN
40insulin receptor signaling pathwayGO:0082868.7IGF1R, IGF2, AKT1, NRAS, RPS6KB1, MAPK1
41negative regulation of cell proliferationGO:0082858.7TP53, PTEN, PTGS2, CTNNB1, NF2, WT1
42Ras protein signal transductionGO:0072658.6NF1, NRAS, TP53, IGF1, MAPK1, GRB2
43positive regulation of transcription from RNA polymerase II promoterGO:0459448.4CTNNB1, SMARCB1, RPS27A, HIF1A, TCF3, STAT3
44axon guidanceGO:0074118.1ERBB2, PTK2, NRAS, EGFR, ABL1, PRKCQ
45apoptotic processGO:0069157.9VIM, CASP4, CASP6, CASP1, CASP2, CASP14
46epidermal growth factor receptor signaling pathwayGO:0071737.9PTEN, NRAS, RPS27A, EGFR, HBEGF, ADAM17
47platelet activationGO:0301687.4ALB, AKT1, PTK2, PDGFA, PRKCQ, PECAM1
48signal transductionGO:0071657.3EGFR, PDGFRB, RPS6KB1, TEK, ERBB2, ESR1
49negative regulation of apoptotic processGO:0430667.1RAF1, BCL2, CDKN1A, CD44, ITGA6, FGFR1
50blood coagulationGO:0075966.8IGF1, ALB, AKT1, TP53, TEK, PTK2

Molecular functions related to gastrointestinal stromal tumor according to GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1succinate dehydrogenase activityGO:00010410.5SDHA, SDHC, SDHD
2cysteine-type endopeptidase activityGO:00419710.2CASP9, CASP8, CASP5, CASP14, CASP2, CASP1
3receptor tyrosine kinase bindingGO:03097110.2ANGPT4, ANGPT1, ANXA5, ANGPT2, PCNA
4growth factor activityGO:00808310.0HDGF, CSF1, HBEGF, PDGFA, IGF1, IGF2
5cyclin-dependent protein kinase inhibitor activityGO:0048619.8CDKN1A, CDKN2B, CDKN2A, CASP3
6transmembrane receptor protein tyrosine kinase activityGO:0047149.7TIE1, EGFR, PDGFRA, NTRK3, TEK, ERBB2
7nitric-oxide synthase regulator activityGO:0302359.6EGFR, ESR1, AKT1, HSP90AB1, HSP90AA1
8transcription factor bindingGO:0081349.5CTNNB1, HIF1A, TCF3, STAT3, E2F1, TP73
9protein homodimerization activityGO:0428039.4PTGS2, PDGFA, PDGFRA, ABCG2, TKT, TCF3
10protein tyrosine kinase activityGO:0047139.3PDGFRB, EGFR, ABL1, OBSCN, TEK, ERBB2
11insulin receptor substrate bindingGO:0435609.3IGF1R, GRB2, JAK2, PIK3R1, PIK3CA
12protein kinase bindingGO:0199018.7TP73, PTEN, PTK2, HIF1A, STAT3, ADIPOR1
13protein phosphatase bindingGO:0199038.3EGFR, CTNNB1, ERBB2, GRB2, CDH1, PIK3R1
14protein heterodimerization activityGO:0469828.0ADIPOR1, ADIPOR2, TCF3, HIF1A, EGFR, PDGFA
15enzyme bindingGO:0198997.8PGR, STAT1, HIF1A, EGFR, CTNNB1, PTGS2
16identical protein bindingGO:0428027.1GRB2, IGF1R, HSP90AA1, CASP8, GLUD1, AKT1
17ATP bindingGO:0055246.8ABCB1, EGFR, PDGFRB, PDGFRA, RPS6KB1, NTRK3
18protein bindingGO:0055151.2AKT1, PDGFRB, WT1, NDRG2, KLK3, EGFR

Sources for Gastrointestinal Stromal Tumor

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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