GANT
MCID: GST019
MIFTS: 83

Gastrointestinal Stromal Tumor (GANT) malady

Gastrointestinal diseases, Cancer diseases categories

Summaries for Gastrointestinal Stromal Tumor

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Sources:
21Genetics Home Reference, 42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Gastrointestinal stromal tumors are a type of soft tissue sarcoma (tumor) that usually begins in cells in the wall of the stomach, intestines, or rectum. these tumors may be noncancerous or cancerous. they can affect adults, adolescents, or children.  it is estimated that around 5,000 new cases of gastrointestinal stromal tumors are diagnosed in the united states each year. last updated: 4/27/2010

MalaCards: Gastrointestinal Stromal Tumor, also known as gastrointestinal stromal tumors, is related to neurofibromatosis and adenocarcinoma, and has symptoms including intestinal perforation, intestinal obstruction/ileus and gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia. An important gene associated with Gastrointestinal Stromal Tumor is SDHB (succinate dehydrogenase complex, subunit B, iron sulfur (Ip)), and among its related pathways are PIP3 activates AKT signaling and Nanog in Mammalian ESC Pluripotency. The compounds tyrosine and vegf have been mentioned in the context of this disorder. Affiliated tissues include small intestine, colon and liver, and related mouse phenotypes are mortality/aging and growth/size.

Genetics Home Reference:21 A gastrointestinal stromal tumor (GIST) is a type of tumor that occurs in the gastrointestinal tract, most commonly in the stomach or small intestine. The tumors are thought to grow from specialized cells found in the gastrointestinal tract called interstitial cells of Cajal (ICCs) or precursors to these cells. GISTs are usually found in adults between ages 40 and 70 and can be cancerous (malignant) or noncancerous (benign).

Wikipedia:63 Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal... more...

Description from OMIM:46 606764

Aliases & Classifications for Gastrointestinal Stromal Tumor

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Sources:
8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 20GeneTests, 22GTR, 21Genetics Home Reference, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Gastrointestinal diseases


Characteristics (Orphanet epidemiological data):

48
gastrointestinal stromal tumor:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Adulthood


Aliases & Descriptions:

gastrointestinal stromal tumor 8 9 21 46 10 44 48
gastrointestinal stromal tumors 42 20 22 60
gist 8 42 21 48
gastrointestinal stromal sarcoma 42 21 60
stromal tumor of gastrointestinal tract 8
gastrointestinal stromal neoplasm 21
gant 8


External Ids:

Disease Ontology8 DOID:9253
NCIt39 C3868
MeSH34 D046152
OMIM46 606764
MESH via Orphanet35 D046152
ICD10 via Orphanet26 C26.9
SNOMED-CT via Orphanet57 128756002, 420120006
UMLS via Orphanet61 C0238198

Related Diseases for Gastrointestinal Stromal Tumor

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Gastrointestinal Stromal Tumor family:

Gastrointestinal Stromal Tumor, Familial

Diseases related to Gastrointestinal Stromal Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 285)
idRelated DiseaseScoreTop Affiliating Genes
1neurofibromatosis31.2KIT, NF2, SDHB, PDGFRA, S100B, KITLG
2adenocarcinoma31.0VIM, NF2, PDGFRB, NES, ACTC1, KITLG
3leiomyoma31.0VIM, S100B, S100A1, PDGFRA, NES, ACTC1
4leiomyosarcoma30.9VIM, S100B, ACTC1, KIT, CD34, DES
5pancreatitis30.9KITLG
6sarcoma30.8KIT, ACTC1, KITLG, CD34, VIM, S100B
7leukemia30.7NES, PDGFRA, PDGFRB, CD34, KITLG, KIT
8smooth muscle tumor30.7ACTC1, DES, S100A1, KIT, VIM, S100B
9paraganglioma30.7S100A1, SDHB, SDHC, SDHA, S100B, KIT
10pheochromocytoma30.6SDHB, SDHC, SDHA
11myeloid leukemia30.6KITLG, CD34, KIT
12melanoma30.5CD34, KITLG, KIT, NF2, PDGFRB, ACTC1
13giant cell tumor30.5ACTC1, S100B, DES, VIM
14malignant peripheral nerve sheath tumor30.3KIT, CD34, NF2, S100A1, S100B, VIM
15adenoma30.3S100A1, SV2A, KITLG, NES, ACTC1
16granular cell tumor30.3S100B, VIM, S100A1, DES
17acute leukemia30.3KIT, KITLG, CD34
18gastrointestinal stromal tumor, somatic30.3KIT, PDGFRA
19paraganglioma and gastric stromal sarcoma30.3SDHB, SDHC
20neurofibroma30.1VIM, S100A1, KITLG, CD34, NF2, PDGFRA
21breast cancer30.1ETV1, NES, KIT, SDHC, SDHB, NF2
22hemangiopericytoma30.1DES, CD34, VIM, S100B, ACTC1, S100A1
23meningioma30.1PDGFRB, NF2, S100A1, S100B, CD34, VIM
24glomus tumor30.1SDHB, ACTC1, DES, S100A1, VIM
25synovial sarcoma30.1KIT, VIM, S100B, NES, DES
26colorectal cancer30.1CD34, KITLG, PDGFRB, NF2, PDGFRA
27angiosarcoma30.1CD34, PDGFRA, VIM, ACTC1
28chronic myeloid leukemia30.1KITLG, KIT, PDGFRB, PDGFRA, CD34
29perineurioma30.1VIM, CD34, S100B
30ovarian cancer30.1NF2, PDGFRA, PDGFRB, CD34
31osteosarcoma30.1PDGFRA, NF2, PDGFRB
32chondroma30.1SDHC, PDGFRA, SDHB
33polycythemia vera30.1KITLG, PDGFRA, PDGFRB, KIT
34polycythemia30.1CD34, KITLG
35adenosarcoma30.1ACTC1, DES
36stomach cancer30.1SDHB, CD34
37hepatocellular carcinoma30.1PDGFRA, CD34
38urticaria pigmentosa30.1KITLG, KIT
39liposarcoma29.8CD34, VIM, DES
40clear cell sarcoma29.8KIT, S100B
41duodenitis10.7
42esophagitis10.6
43intussusception10.5
44gastric adenocarcinoma10.5
45gastrointestinal lymphoma10.5
46hypoglycemia10.5
47prostatitis10.5
48meckel's diverticulum10.4
49gastrointestinal neuroendocrine tumor10.4
50neuroendocrine tumor10.4

Graphical network of the top 20 diseases related to Gastrointestinal Stromal Tumor:



Diseases related to gastrointestinal stromal tumor

Clinical Features for Gastrointestinal Stromal Tumor

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Sources:
46OMIM, 48Orphanet
See all sources

Clinical features from OMIM:

606764

Clinical synopsis from OMIM:

606764

Symptoms:

48 (show all 18)
  • intestinal perforation
  • intestinal obstruction/ileus
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • constipation
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia
  • sarcoma
  • asthenia/fatigue/weakness
  • cutaneous rash
  • irregular/in bands/reticular skin hyperpigmentation
  • hepatitis/icterus/cholestasis
  • anaemia
  • digestive neoplasm/tumor/carcinoma/cancer
  • esophageal neoplasm/tumor/carcinoma/cancer
  • small bowel neoplasm/tumor/carcinoma/cancer
  • colon neoplasm/tumor/carcinoma/cancer
  • rectum/rectal neoplasm/tumor/carcinoma/cancer
  • estomach/gastric neoplasm/tumor/carcinoma/cancer

Drugs & Therapeutics for Gastrointestinal Stromal Tumor

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Gastrointestinal Stromal Tumor

Drug clinical trials:

Search ClinicalTrials for Gastrointestinal Stromal Tumor

Search NIH Clinical Center for Gastrointestinal Stromal Tumor

Search CenterWatch for Gastrointestinal Stromal Tumor

Genetic Tests for Gastrointestinal Stromal Tumor

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20GeneTests, 22GTR
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Genetic tests related to Gastrointestinal Stromal Tumor:

id Genetic test Affiliating Genes
1 Gastrointestinal Stromal Tumor20 PDGFRA
2 Gastrointestinal Stromal Tumors22

Anatomical Context for Gastrointestinal Stromal Tumor

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32MalaCards
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MalaCards organs/tissues related to Gastrointestinal Stromal Tumor:

32
Small intestine, Colon, Liver, Bone, Skin, Pancreas, Smooth muscle, Prostate, Endothelial, Appendix, Myeloid, Lymph node, Testes, Thyroid, Brain, Breast, Ovary, Uterus, Skeletal muscle, B cells, Tongue, Heart, T cells, Spleen, Bone marrow

Animal Models for Gastrointestinal Stromal Tumor or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Gastrointestinal Stromal Tumor:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076811.5SDHC, VIM, TLX2, PDGFRB, PDGFRA, NES
2MP:000537811.3VIM, TLX2, PDGFRB, PDGFRA, NES, ANO1
3MP:000538611.3VIM, S100B, S100A1, PDGFRA, NES, DES
4MP:000363111.0TLX2, ANO1, NF2, ETV1, SV2A, KITLG
5MP:000538011.0VIM, TLX2, PDGFRB, PDGFRA, NES, NF2
6MP:000538411.0VIM, PDGFRB, PDGFRA, NES, ETV1, SV2A
7MP:000536911.0PDGFRB, PDGFRA, ANO1, ETV1, ACTC1
8MP:000287311.0S100B, S100A1, PDGFRB, PDGFRA, ETV1, SV2A
9MP:000537610.9DES, PDGFRA, PDGFRB, VIM, ANO1, NF2
10MP:001077110.9S100B, PDGFRA, ANO1, CD34, KITLG
11MP:000538210.8PDGFRB, PDGFRA, NF2, KITLG, KIT, TLX2
12MP:000538510.6VIM, S100A1, PDGFRB, PDGFRA, DES, KITLG

Publications for Gastrointestinal Stromal Tumor

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50PubMed
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Articles related to Gastrointestinal Stromal Tumor:

(show top 50)    (show all 1106)
idTitleAuthorsYear
1
Accessory spleen arising from the gastric fundus mimicking gastrointestinal stromal tumor following splenectomy: A case report. (24396402)
2014
2
Radiofrequency ablation for liver metastasis from gastrointestinal stromal tumor. (23352855)
2013
3
Intracellular concentration of the tyrosine kinase inhibitor imatinib in gastrointestinal stromal tumor cells. (24361761)
2013
4
Regorafenib: a guide to its use in advanced gastrointestinal stromal tumor (GIST) after failure of imatinib and sunitinib. (23975637)
2013
5
Loss of DOG-1 expression associated with shift from spindled to epithelioid morphology in gastric gastrointestinal stromal tumors with KIT and platelet-derived growth factor receptor I+ mutations. (23218903)
2013
6
Cytokeratin-positive epithelioid gastrointestinal stromal tumor of the stomach - a comment on "gastric undifferentiated carcinoma with diffuse c-kit overexpression and focal neuroendocrine differentiation". (23726927)
2013
7
A hemodialysis patient with primary extra-gastrointestinal stromal tumor: favorable outcome with imatinib mesylate. (22728491)
2012
8
Duodenal gastrointestinal stromal tumor presenting with acute upper gastrointestinal bleeding treated with segmental resection. (22533888)
2012
9
C-KIT mutations were closely associated with the response to Imatinib in Chinese advanced gastrointestinal stromal tumor patients. (22815156)
2012
10
Prolonged Therapy with Imatinib Mesylate before Surgery for Advanced Gastrointestinal Stromal Tumor Results of a Phase II Trial. (23316352)
2012
11
Unusual metastases of gastrointestinal stromal tumor and genotypic correlates: Case report and review of the literature. (22811827)
2011
12
Down-regulation of miR-221 and miR-222 correlates with pronounced Kit expression in gastrointestinal stromal tumors. (21132270)
2011
13
Gastrointestinal stromal tumor: advances in diagnosis and management. (21970485)
2011
14
Gynecomastia during imatinib mesylate treatment for gastrointestinal stromal tumor: a rare adverse event. (22047550)
2011
15
SDHA loss-of-function mutations in KIT-PDGFRA wild-type gastrointestinal stromal tumors identified by massively parallel sequencing. (21505157)
2011
16
VEGF expression is related to good response and long progression-free survival in gastrointestinal stromal tumor patients treated with Sunitinib. (21817899)
2011
17
KIT and PDGFRA mutations and PDGFRA immunostaining in gastrointestinal stromal tumors. (21461555)
2011
18
Malignant gastrointestinal stromal tumor of the tongue: case report and review of the literature. (21497732)
2011
19
First report of connexin 43-positive gastrointestinal stromal tumor (GIST). (21462830)
2010
20
En bloc resection of the pancreatic head and second part of duodenum for a duodenal gastrointestinal stromal tumor: a multi-media report. (20601819)
2010
21
Duodenal gastrointestinal stromal tumor resembling a pancreatic neuroendocrine tumor in a patient with neurofibromatosis type I (von Recklinghausen's disease): a case report. (20825631)
2010
22
Mesenteric fibromatosis mimicking a gastrointestinal stromal tumor. (20440999)
2010
23
Expression of MDR1 and KIT in imatinib-resistant gastrointestinal stromal tumor cells]. (20658364)
2010
24
Laparoscopic excision is an alterative method for rectal gastrointestinal stromal tumor. (20729704)
2010
25
Detection of treatment-induced changes in signaling pathways in gastrointestinal stromal tumors using transcriptomic data. (19903850)
2009
26
Rhabdomyosarcomatous differentiation in gastrointestinal stromal tumors after tyrosine kinase inhibitor therapy: a novel form of tumor progression. (18830121)
2009
27
Perioperative treatment of gastrointestinal stromal tumors. (19283922)
2009
28
High density DNA array analysis reveals distinct genomic profiles in a subset of gastrointestinal stromal tumors. (19585585)
2009
29
PDGFRA immunostaining can help in the diagnosis of gastrointestinal stromal tumors. (18360281)
2008
30
A review of resistance patterns and phenotypic changes in gastrointestinal stromal tumors following imatinib mesylate therapy. (17417711)
2007
31
Pathologic and molecular heterogeneity in imatinib-stable or imatinib-responsive gastrointestinal stromal tumors. (17200352)
2007
32
Presence of homozygous KIT exon 11 mutations is strongly associated with malignant clinical behavior in gastrointestinal stromal tumors. (17632543)
2007
33
Histone H2AX is a mediator of gastrointestinal stromal tumor cell apoptosis following treatment with imatinib mesylate. (17363589)
2007
34
Diagnostic morphological features of PDGFRA-mutated gastrointestinal stromal tumors: molecular genetic and histologic analysis of 60 cases of gastric gastrointestinal stromal tumors. (17240304)
2007
35
Multicentric sporadic gastrointestinal stromal tumors (GISTs) of the stomach with distinct clonal origin: differential diagnosis to familial and syndromal GIST variants and peritoneal metastasis. (17527083)
2007
36
Association of intratumoral vascular endothelial growth factor expression and clinical outcome for patients with gastrointestinal stromal tumors treated with imatinib mesylate. (18006774)
2007
37
Clinical analysis of 60 cases with malignant gastrointestinal stromal tumors]. (17043962)
2006
38
Genetic and pathologic characteristics of gastrointestinal stromal tumors in extragastric lesions. (17089009)
2006
39
STI571 (Glivec) induces cell death in the gastrointestinal stromal tumor cell line, GIST-T1, via endoplasmic reticulum stress response. (16596277)
2006
40
PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib. (15928335)
2005
41
Expression and clinical significance of p27 protein and cyclinD1 protein in gastrointestinal stromal tumors]. (16029637)
2005
42
Patterns of gene amplification in gastrointestinal stromal tumors (GIST). (15864317)
2005
43
Differential expression of KIT/PDGFRA mutant isoforms in epithelioid and mixed variants of gastrointestinal stromal tumors depends predominantly on the tumor site. (15154005)
2004
44
KIT-negative gastrointestinal stromal tumors: proof of concept and therapeutic implications. (15223958)
2004
45
Primary malignant gastrointestinal stromal tumor of the liver. (14632569)
2003
46
Gastrointestinal stromal tumors (GIST): a model for molecule-based diagnosis and treatment of solid tumors. (12824897)
2003
47
Overexpression of high mobility group box 1 in gastrointestinal stromal tumors with KIT mutation. (12727838)
2003
48
Cyclin D3 immunoreactivity in gastrointestinal stromal tumors is independent of cyclin D3 gene amplification and is associated with nuclear p27 accumulation. (13679452)
2003
49
Challenging and unusual cases: Case 2. Concurrent gastrointestinal stromal tumor and Burkitt's lymphoma. (12663737)
2003
50
Biological analysis of gastrointestinal stromal tumors. (12375034)
2002

Genetic Variations for Gastrointestinal Stromal Tumor

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Sources:
62UniProtKB/Swiss-Prot
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Genetic disease variations for Gastrointestinal Stromal Tumor:

62
id Symbol AA change Variation ID SNP ID
1KITp.Lys550IleVAR_033123rs28933968
2KITp.Val559AlaVAR_033126
3KITp.Val559AspVAR_033127
4PDGFRAp.Tyr849CysVAR_066474

Expression for genes affiliated with Gastrointestinal Stromal Tumor

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Gastrointestinal Stromal Tumor

Search GEO for disease gene expression data for Gastrointestinal Stromal Tumor.

Pathways for genes affiliated with Gastrointestinal Stromal Tumor

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Sources:
53Reactome, 51QIAGEN, 4Cell Signaling Technology, 12EMD Millipore, 37NCBI BioSystems Database, 29KEGG, 49PharmGKB
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Pathways related to Gastrointestinal Stromal Tumor according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.8S100B, PDGFRB, PDGFRA, KITLG, KIT
2
Hide members
10.7KIT, KITLG, PDGFRA, PDGFRB, VIM
3
Hide members
10.7PDGFRB, PDGFRA, ETV1, KITLG, KIT
4
Hide members
10.7KIT, KITLG, PDGFRA, PDGFRB
510.7PDGFRB, PDGFRA, KITLG, KIT
6
Hide members
10.7PDGFRB, PDGFRA, KITLG, KIT
7
Hide members
10.7DES, PDGFRA, PDGFRB, VIM
810.7VIM, DES, NF2, ACTC1
9
Hide members
10.6SDHA, SDHC, SDHB
10
Hide members
10.6SDHA, SDHC, SDHB
11
Hide members
10.6SDHA, SDHC, SDHB
1210.6ACTC1, KIT, PDGFRA
13
Hide members
10.6PDGFRB, PDGFRA, KIT
1410.6NF2, PDGFRA, PDGFRB
15
Hide members
10.6VIM, DES, ACTC1
16
Hide members
10.6DES, NES, VIM
1710.6KIT, KITLG, CD34
1810.6KIT, KITLG, CD34
1910.6PDGFRB, PDGFRA

Compounds for genes affiliated with Gastrointestinal Stromal Tumor

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Sources:
44Novoseek, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB
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Compounds related to Gastrointestinal Stromal Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1tyrosine4411.7NES, SV2A, CD34, KITLG, NF2, DES
2vegf4411.6PDGFRA, PDGFRB, S100B, VIM, SDHC, NES
3paraffin4411.6KIT, ACTC1, VIM, S100B, S100A1, PDGFRB
4retinoic acid44 2412.6S100B, PDGFRB, VIM, PDGFRA, DES, CD34
5progesterone44 59 28 11 2415.4CD34, PDGFRB, ACTC1, NF2, DES, KIT
6calcium44 49 11 2414.4KITLG, S100B, DES, ANO1, SV2A, KIT
7iron44 2412.4S100B, S100A1, DES, KITLG, ACTC1, SDHB
8testosterone44 59 11 2414.4VIM, ACTC1, SDHB, KIT, ETV1, PDGFRB
9hematoxylin4411.3S100A1, CD34, KIT, ACTC1, S100B, VIM
10imatinib44 49 1113.3S100B, PDGFRA, PDGFRB, KIT, DES, KITLG
11oxygen44 2412.3S100B, NES, DES, KITLG, SDHB, SDHC
12cysteine4411.3S100A1, S100B, SDHB, KIT, NF2, DES
13bromodeoxyuridine4411.2S100B, VIM, NES, KITLG, DES, PDGFRB
14toluidine4411.2DES, KITLG, KIT, VIM, S100A1
15reticulin4411.2VIM, S100B, DES, ACTC1, CD34
16rapamycin4411.2KITLG, KIT, PDGFRB, NF2, VIM, PDGFRA
17mucicarmine4411.2S100B, ACTC1, DES, S100A1, VIM
18b 7234411.2VIM, S100B, ACTC1, S100A1, DES
19biotin44 11 2413.1DES, S100A1, VIM, ACTC1, KITLG
20formaldehyde44 2412.1VIM, S100B, KIT, ACTC1, DES
21orcein4411.1ACTC1, DES, S100B, VIM
22s 1004411.1VIM, ACTC1, S100B, DES
23lactate4411.1SDHB, S100B, KITLG, VIM, DES, KIT
24ag-12964411.1PDGFRA, PDGFRB, KITLG, KIT
25thymidine44 2412.1KIT, KITLG, S100B, CD34, PDGFRA, DES
26glycogen44 2412.0KIT, SDHB, ACTC1
27UBIQUINONE-11111.0SDHA, SDHC, SDHB
28glucose4411.0SDHB, ACTC1, KITLG, PDGFRB
29agar4411.0NF2, CD34, PDGFRB, KITLG, VIM
30monochloroacetic acid4411.0KITLG, KIT, VIM
31acetylcholine44 49 28 11 2415.0S100A1, NES, SV2A
32pkc 4124411.0KIT, PDGFRA, PDGFRB
33ganglioside4411.0PDGFRB, DES, NES, VIM
342-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol1111.0SDHA, SDHC, SDHB
352-methoxyethanol4411.0S100A1, VIM, ACTC1
36su54164411.0KITLG, PDGFRB, KIT
37Pazopanib1111.0KIT, PDGFRA, PDGFRB
38methionine4410.9PDGFRB, VIM, DES, S100B, KIT
39fluorochrome4410.9KIT, CD34, VIM
40rhodamine 12344 4911.9KITLG, CD34, KIT
41creatinine4410.9ACTC1, SDHB, KITLG
42Regorafenib1110.9KIT, PDGFRA, PDGFRB
43sunitinib44 49 1112.8PDGFRA, KIT, PDGFRB
44iron-sulfur4410.8SDHB, SDHC, SDHA
45paclitaxel44 49 1112.7S100B, PDGFRB
46succinic acid28 11 2412.7SDHC, SDHA, SDHB
47ubiquinone4410.6SDHA, SDHB, SDHC
48actomyosin4410.6ACTC1, S100A1, VIM
49gold4410.5SV2A, DES
50Becaplermin1110.3PDGFRB, PDGFRA

GO Terms for genes affiliated with Gastrointestinal Stromal Tumor

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Sources:
16Gene Ontology
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Cellular components related to Gastrointestinal Stromal Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573711.1DDX39A, PDGFRA, PDGFRB, S100B, TLX2, VIM
2mitochondrial respiratory chain complex IIGO:00574910.6SDHA, SDHC, SDHB
3intermediate filamentGO:00588210.6DES, NES, VIM
4intrinsic to plasma membraneGO:03122610.3PDGFRA, PDGFRB

Biological processes related to Gastrointestinal Stromal Tumor according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1phosphatidylinositol-mediated signalingGO:04801511.0PDGFRB, PDGFRA, KITLG, KIT
2positive regulation of phospholipase C activityGO:01086311.0KIT, PDGFRA, PDGFRB
3cardiac myofibril assemblyGO:05500311.0ACTC1, PDGFRA, PDGFRB
4cell chemotaxisGO:06032611.0PDGFRB, PDGFRA, KIT
5positive regulation of phosphatidylinositol 3-kinase activityGO:04355211.0KIT, PDGFRA, PDGFRB
6tricarboxylic acid cycleGO:00609911.0SDHA, SDHC, SDHB
7fibroblast growth factor receptor signaling pathwayGO:00854311.0KIT, KITLG, PDGFRA, PDGFRB
8muscle filament slidingGO:03004910.9VIM, DES, ACTC1
9Fc-epsilon receptor signaling pathwayGO:03809510.9KIT, KITLG, PDGFRA, PDGFRB
10positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathwayGO:03809110.9PDGFRA, PDGFRB
11positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406810.9PDGFRB, PDGFRA, KIT
12metanephric glomerular capillary formationGO:07227710.9PDGFRA, PDGFRB
13epidermal growth factor receptor signaling pathwayGO:00717310.9PDGFRB, PDGFRA, KITLG, KIT
14germ cell programmed cell deathGO:03523410.9KIT, KITLG
15peptidyl-tyrosine phosphorylationGO:01810810.8PDGFRB, PDGFRA, KIT
16hemopoiesisGO:03009710.8KIT, KITLG, CD34
17innate immune responseGO:04508710.8KIT, KITLG, PDGFRA, PDGFRB, S100B
18stem cell proliferationGO:07208910.7NES, CD34
19retina vasculature development in camera-type eyeGO:06129810.7PDGFRB, PDGFRA
20succinate metabolic processGO:00610510.6SDHA, SDHB
21respiratory electron transport chainGO:02290410.5SDHA, SDHC, SDHB
22neurotrophin TRK receptor signaling pathwayGO:04801110.4PDGFRB, PDGFRA, KITLG, KIT

Molecular functions related to Gastrointestinal Stromal Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.3VIM, S100B, S100A1, PDGFRB, PDGFRA, DDX39A
2succinate dehydrogenase (ubiquinone) activityGO:00817710.7SDHA, SDHB
3vascular endothelial growth factor bindingGO:03808510.6PDGFRB, PDGFRA
4platelet-derived growth factor receptor bindingGO:00516110.6PDGFRA, PDGFRB
5S100 protein bindingGO:04454810.5S100A1, S100B
6platelet-derived growth factor bindingGO:04840710.3PDGFRA, PDGFRB

Products for genes affiliated with Gastrointestinal Stromal Tumor

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Sources for Gastrointestinal Stromal Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet