GANT
MCID: GST019
MIFTS: 82

Gastrointestinal Stromal Tumor (GANT) malady

Genetic diseases, Rare diseases, Gastrointestinal diseases, Cancer diseases categories
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Summaries for Gastrointestinal Stromal Tumor

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Sources:
21Genetics Home Reference, 43NIH Rare Diseases, 65Wikipedia, 47OMIM, 33MalaCards
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NIH Rare Diseases:43 Gastrointestinal stromal tumors are a type of soft tissue sarcoma (tumor) that usually begins in cells in the wall of the stomach, intestines, or rectum. these tumors may be noncancerous or cancerous. they can affect adults, adolescents, or children.  it is estimated that around 5,000 new cases of gastrointestinal stromal tumors are diagnosed in the united states each year. last updated: 4/27/2010

MalaCards: Gastrointestinal Stromal Tumor, also known as gastrointestinal stromal sarcoma, is related to neurofibromatosis and adenocarcinoma, and has symptoms including feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia, constipation and asthenia/fatigue/weakness. An important gene associated with Gastrointestinal Stromal Tumor is SDHB (succinate dehydrogenase complex, subunit B, iron sulfur (Ip)), and among its related pathways are Osteoblast Signaling and Carbon metabolism. The compounds monochloroacetic acid and pkc 412 have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and liver, and related mouse phenotypes are limbs/digits/tail and hearing/vestibular/ear.

Genetics Home Reference:21 A gastrointestinal stromal tumor (GIST) is a type of tumor that occurs in the gastrointestinal tract, most commonly in the stomach or small intestine. The tumors are thought to grow from specialized cells found in the gastrointestinal tract called interstitial cells of Cajal (ICCs) or precursors to these cells. GISTs are usually found in adults between ages 40 and 70 and can be cancerous (malignant) or noncancerous (benign).

Wikipedia:65 Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal... more...

Description from OMIM:47 606764

Aliases & Classifications for Gastrointestinal Stromal Tumor

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Sources:
8Disease Ontology, 9diseasecard, 21Genetics Home Reference, 47OMIM, 10DISEASES, 45Novoseek, 49Orphanet, 43NIH Rare Diseases, 20GeneTests, 22GTR, 62UMLS, 40NCIt, 58SNOMED-CT, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
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Classifications:



Characteristics (Orphanet epidemiological data):

49
gastrointestinal stromal tumor:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Adulthood


Aliases & Descriptions:

gastrointestinal stromal tumor 8 9 21 47 10 45 49
gastrointestinal stromal sarcoma 43 21 49 62
gastrointestinal stromal tumors 43 20 22 62
gist 8 43 21 49
stromal tumor of gastrointestinal tract 8
gastrointestinal stromal neoplasm 21
gant 8


External Ids:

Disease Ontology8 DOID:9253
NCIt40 C3868
MeSH35 D046152
OMIM47 606764
MESH via Orphanet36 D046152
ICD10 via Orphanet26 C26.9
SNOMED-CT via Orphanet59 128756002, 420120006
UMLS via Orphanet63 C0238198

Related Diseases for Gastrointestinal Stromal Tumor

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17GeneCards, 18GeneDecks
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Diseases in the Gastrointestinal Stromal Tumor family:

Gastrointestinal Stromal Tumor, Familial

Diseases related to Gastrointestinal Stromal Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 270)
idRelated DiseaseScoreTop Affiliating Genes
1neurofibromatosis31.3NF2, SDHB
2adenocarcinoma31.1CD34, NF2, KITLG, PDGFRB, CSF1R, ITGA6
3leiomyoma31.1CD34, KIT, S100B, S100A1, PDGFRA, ACTC1
4fibromatosis31.0CD34, KIT, S100A1, PDGFRB, ACTC1, VIM
5leiomyosarcoma31.0CD34, KIT, S100B, S100A1, PDGFRB, PDGFRA
6leukemia30.8CD34, KITLG, KIT, PDGFRB, PDGFRA, CSF1R
7desmoid tumor30.8KIT, PDGFRB, PDGFRA, ACTC1, DES
8carney triad30.8KIT, PDGFRA, SDHC, SDHB
9myeloid leukemia30.7CD34, KITLG, KIT, CSF1R, FLT3
10sarcoma30.7CD34, NF2, KITLG, KIT, S100B, S100A1
11paraganglioma30.6KIT, S100B, S100A1, SDHA, SDHC, SDHB
12acute myeloid leukemia30.6KIT, FLT3
13granular cell tumor30.6S100B, S100A1, VIM, DES
14adenoma30.5KITLG, S100A1, ITGA6, ACTC1, NES, MKI67
15malignant peripheral nerve sheath tumor30.5CD34, NF2, KIT, S100B, S100A1, PDGFRA
16paraganglioma and gastric stromal sarcoma30.4SDHC, SDHB
17adenosarcoma30.4ACTC1, DES
18urticaria pigmentosa30.4KITLG, KIT
19melanoma30.4CD34, NF2, KITLG, KIT, S100B, S100A1
20perineurioma30.4CD34, S100B, VIM
21refractory anemia30.4KITLG, KIT, FLT3
22mastocytosis30.3KITLG, KIT, PDGFRB, PDGFRA
23angiosarcoma30.3CD34, PDGFRA, ACTC1, VIM
24osteosarcoma30.3NF2, PDGFRB, PDGFRA, CSF1R
25hemangiopericytoma30.3CD34, S100B, S100A1, ACTC1, VIM, DES
26chronic myeloid leukemia30.3CD34, KITLG, KIT, PDGFRB, PDGFRA, FLT3
27colorectal cancer30.3CD34, NF2, KITLG, PDGFRB, PDGFRA
28ovarian cancer30.3CD34, NF2, PDGFRB, PDGFRA, CSF1R
29synovial sarcoma30.3KIT, S100B, NES, VIM, MKI67, DES
30hepatocellular carcinoma30.3CD34, PDGFRA, CSF1R, ITGA6, MKI67
31smooth muscle tumor30.3KIT, S100B, S100A1, ACTC1, VIM, MKI67
32burkitt's lymphoma30.3CD34, S100A1, CSF1R, ACTC1, FLT3, MKI67
33myelodysplastic syndromes30.3CD34, KITLG, KIT, PDGFRB, PDGFRA, CSF1R
34glomus tumor30.2S100A1, ACTC1, VIM, SDHB, DES
35meningioma30.2CD34, NF2, S100B, S100A1, PDGFRB, VIM
36dermatofibrosarcoma protuberans30.2CD34, KIT, S100B, S100A1, PDGFRB, ACTC1
37breast cancer30.2NF2, S100A1, CSF1R, ITGA6, ACTC1, VIM
38chondroma30.2PDGFRA, SDHC, SDHB
39neurofibroma30.2CD34, NF2, KITLG, KIT, S100B, S100A1
40multiple endocrine neoplasia30.2NF2, SDHC, SDHB
41multiple endocrine neoplasia type 2a30.2SDHC, SDHB
42duodenitis10.8
43esophagitis10.6
44pancreatitis10.6
45intussusception10.6
46prostatitis10.5
47meckel's diverticulum10.5
48hypoglycemia10.5
49gastric adenocarcinoma10.5
50peritonitis10.5

Graphical network of the top 20 diseases related to Gastrointestinal Stromal Tumor:



Diseases related to gastrointestinal stromal tumor

Symptoms for Gastrointestinal Stromal Tumor

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Sources:
47OMIM, 49Orphanet
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Symptoms by clinical synopsis from OMIM:

606764

Clinical features from OMIM:

606764

Symptoms:

49 (show all 18)
  • feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia
  • constipation
  • asthenia/fatigue/weakness
  • hepatitis/icterus/cholestasis
  • anaemia
  • cutaneous rash
  • irregular/in bands/reticular skin hyperpigmentation
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • intestinal obstruction/ileus
  • colon neoplasm/tumor/carcinoma/cancer
  • sarcoma
  • digestive neoplasm/tumor/carcinoma/cancer
  • esophageal neoplasm/tumor/carcinoma/cancer
  • estomach/gastric neoplasm/tumor/carcinoma/cancer
  • small bowel neoplasm/tumor/carcinoma/cancer
  • rectum/rectal neoplasm/tumor/carcinoma/cancer
  • intestinal perforation
  • nausea/vomiting/regurgitation/merycism/hyperemesis

Drugs & Therapeutics for Gastrointestinal Stromal Tumor

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Gastrointestinal Stromal Tumor

Search NIH Clinical Center for Gastrointestinal Stromal Tumor

Genetic Tests for Gastrointestinal Stromal Tumor

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20GeneTests, 22GTR
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Genetic tests related to Gastrointestinal Stromal Tumor:

id Genetic test Affiliating Genes
1 Gastrointestinal Stromal Tumor20 PDGFRA
2 Gastrointestinal Stromal Tumors22

Anatomical Context for Gastrointestinal Stromal Tumor

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33MalaCards
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MalaCards organs/tissues related to Gastrointestinal Stromal Tumor:

33
Colon, Small intestine, Liver, Bone, Skin, Pancreas, Prostate, Endothelial, Smooth muscle, Lymph node, Myeloid, Appendix, Testes, Thyroid, Brain, Breast, Spleen, Uterus, Bone marrow, Heart, Skeletal muscle, T cells, B cells, Ovary, Tongue

Animal Models for Gastrointestinal Stromal Tumor or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Gastrointestinal Stromal Tumor:

37 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.7KIT, PDGFRA, CSF1R, ITGA6, KITLG
2MP:00053779.6CSF1R, KIT, KITLG, ITGA6, NF2
3MP:00053829.5ITGA6, CSF1R, PDGFRA, PDGFRB, NF2, KIT
4MP:00020069.5KIT, PDGFRA, ITGA6, KITLG, NF2, CD34
5MP:00053919.5ITGA6, PDGFRB, KIT, KITLG, VIM, SDHC
6MP:00053699.4KIT, S100A1, PDGFRB, PDGFRA, ACTC1, ETV1
7MP:00053809.4KITLG, PDGFRA, NF2, KIT, PDGFRB, ITGA6
8MP:00053799.4NF2, PDGFRA, CSF1R, KITLG, PDGFRB, KIT
9MP:00053859.2ITGA6, ACTC1, VIM, DES, S100A1, KIT
10MP:00107719.2ITGA6, S100B, KITLG, KIT, PDGFRB, PDGFRA
11MP:00028739.1KIT, S100B, S100A1, PDGFRA, ACTC1, ETV1
12MP:00036319.1VIM, NES, ETV1, ITGA6, PDGFRA, KIT
13MP:00053979.0PDGFRB, PDGFRA, FLT3, VIM, ITGA6, KITLG
14MP:00053899.0KITLG, KIT, PDGFRB, PDGFRA, CSF1R, VIM
15MP:00053868.9ETV1, KIT, DES, VIM, NF2, NES
16MP:00053878.9FLT3, CSF1R, ITGA6, PDGFRA, PDGFRB, KIT
17MP:00053768.8CD34, KIT, PDGFRB, PDGFRA, NF2, ACTC1
18MP:00053788.7CSF1R, ITGA6, ETV1, ACTC1, PDGFRA, NES
19MP:00053848.6ETV1, ITGA6, VIM, CSF1R, PDGFRA, PDGFRB
20MP:00107688.4PDGFRA, ITGA6, ACTC1, ETV1, NES, VIM

Publications for Gastrointestinal Stromal Tumor

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52PubMed
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Articles related to Gastrointestinal Stromal Tumor:

(show top 50)    (show all 1087)
idTitleAuthorsYear
1
Angiomatous leiomyoma of the urachus: A rare entity masquerading as extraluminal gastrointestinal stromal tumor. (24049386)
2013
2
Single-incision laparoscopic and endoscopic cooperative surgery for gastrointestinal stromal tumor arising from the duodenum. (24308591)
2013
3
Gastrointestinal stromal tumor of small intestine and synchronous bilateral papillary renal cell carcinoma. (24195178)
2013
4
Gastrointestinal stromal tumor: an unusual cause of gastrointestinal bleeding. (23633157)
2013
5
Gastrointestinal stromal tumor with dedifferentiation to undifferentiated pleomorphic sarcoma. (24200161)
2013
6
Dedifferentiation in gastrointestinal stromal tumor to an anaplastic KIT-negative phenotype: a diagnostic pitfall: morphologic and molecular characterization of 8 cases occurring either de novo or after imatinib therapy. (23348204)
2013
7
Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147) is associated with low survival in patients with gastrointestinal stromal tumors (GISTs). (22281667)
2012
8
Surgical treatment of a giant mesenteric fibromatosis mimicking a gastrointestinal stromal tumor: a case report and current treatment aspects. (23175930)
2012
9
GLP-2 receptors in human disease: high expression in gastrointestinal stromal tumors and Crohn's disease. (22951144)
2012
10
A Case of KIT-Negative Extra-Gastrointestinal Stromal Tumor of the Lesser Omentum. (22855655)
2012
11
Multifocal gastric gastrointestinal stromal tumors (GISTs) with lymph node metastases in children and young adults: a comparative clinical and histomorphological study of three cases including a new case of Carney triad. (21663639)
2011
12
Synchronous double tumor of breast cancer and gastrointestinal stromal tumor in a patient with neurofibromatosis type 1: report of a case. (22199319)
2011
13
Frequency, phenotype, and genotype of minute gastrointestinal stromal tumors in the stomach: an autopsy study. (21658742)
2011
14
Gastrointestinal stromal tumor presenting as dyspareunia. (22234771)
2011
15
CT features, mimics and atypical presentations of gastrointestinal stromal tumor (GIST). (22013291)
2011
16
Recurring gastrointestinal stromal tumor with splenic metastasis. (22319733)
2011
17
Unusual metastases of gastrointestinal stromal tumor and genotypic correlates: Case report and review of the literature. (22811827)
2011
18
Comparison of RECIST and Choi criteria for computed tomographic response evaluation in patients with advanced gastrointestinal stromal tumor treated with sunitinib. (21289369)
2011
19
First report of connexin 43-positive gastrointestinal stromal tumor (GIST). (21462830)
2010
20
Is laparoscopic resection the appropriate management of a jejunal gastrointestinal stromal tumor (GIST)? Report of a case. (20975491)
2010
21
Kinase mutations and efficacy of imatinib in Korean patients with advanced gastrointestinal stromal tumors. (19411681)
2009
22
Aberrations of chromosome 13q in gastrointestinal stromal tumors: analysis of 91 cases by fluorescence in situ hybridization (FISH). (19430298)
2009
23
Expression of CD117, CD34, SMA, S-100 protein, Vim and desmin in patients with gastrointestinal stromal tumors]. (18359707)
2008
24
PDGFRalpha gene mutation and protein expression in gastrointestinal stromal tumors. (18547963)
2008
25
Gastrointestinal stromal tumors: past, present, and future. (18648736)
2008
26
Site-dependent differential KIT and PDGFRA expression in gastric and intestinal gastrointestinal stromal tumors. (17673922)
2007
27
Gastrointestinal Stromal Tumors (GIST) and Their Management. (19360154)
2007
28
Imatinib in gastrointestinal stromal tumor treatment--results from University Hospital Centre Zagreb]. (16910417)
2006
29
Gastrointestinal stromal tumors express the orexigen ghrelin. (16954444)
2006
30
Malignant gastrointestinal stromal tumor of the ampulla of Vater presenting with obstructive jaundice. (16855323)
2006
31
Interobserver variability in histologic recognition, interpretation of KIT immunostaining, and determining MIB-1 labeling indices in gastrointestinal stromal tumors and other spindle cell tumors of the gastrointestinal tract. (16540730)
2006
32
Polyclonal evolution of multiple secondary KIT mutations in gastrointestinal stromal tumors under treatment with imatinib mesylate. (16551858)
2006
33
A long-term survival case with multiple liver metastases from duodenal gastrointestinal stromal tumor that was drastically reduced by the treatment with imatinib]. (16315926)
2005
34
Hypoxia-inducible factor-1alpha is associated with risk of aggressive behavior and tumor angiogenesis in gastrointestinal stromal tumor. (15845570)
2005
35
Serum KIT and KIT ligand levels in patients with gastrointestinal stromal tumors treated with imatinib. (15070666)
2004
36
Current clinical management of gastrointestinal stromal tumors. (15270663)
2004
37
Malignant gastrointestinal stromal tumor originating in the lesser omentum, complicated by rapidly progressive glomerulonephritis and gastric carcinoma. (15005250)
2004
38
A new mutation in the KIT ATP pocket causes acquired resistance to imatinib in a gastrointestinal stromal tumor patient. (15236194)
2004
39
Gastrointestinal stromal tumors in a mouse model by targeted mutation of the Kit receptor tyrosine kinase. (12754375)
2003
40
PDGFRA activating mutations in gastrointestinal stromal tumors. (12522257)
2003
41
Secondary amyloidosis and gastrointestinal stromal tumors. A case report and discussion of pathogenesis. (12683877)
2003
42
Prognostic predictors of gastrointestinal stromal tumors: a multi-institutional analysis of 102 patients with definition of a prognostic index. (12875864)
2003
43
Hypoxia-inducible factor-1alpha expression and angiogenesis in gastrointestinal stromal tumor of the stomach. (12792726)
2003
44
Approval summary: imatinib mesylate in the treatment of metastatic and/or unresectable malignant gastrointestinal stromal tumors. (12374669)
2002
45
Germline-activating mutation in the kinase domain of KIT gene in familial gastrointestinal stromal tumors. (11073817)
2000
46
Specific mutation in exon 11 of c-kit proto-oncogene in a malignant gastrointestinal stromal tumor of the rectum. (11063223)
2000
47
C-kit gene abnormalities in gastrointestinal stromal tumors (tumors of interstitial cells of Cajal. (10665649)
1999
48
Mutations of c-kit JM domain are found in a minority of human gastrointestinal stromal tumors. (10086344)
1999
49
Interstitial cells of Cajal as precursors of gastrointestinal stromal tumors. (10199467)
1999
50
The gastric hypercellular microleiomyoma as a precursor lesion for clinical gastrointestinal stromal tumors. (9416690)
1997

Variations for Gastrointestinal Stromal Tumor

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Sources:
64UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar), 7dbSNP
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UniProtKB/Swiss-Prot genetic disease variations for Gastrointestinal Stromal Tumor:

64
id Symbol AA change Variation ID SNP ID
1KITp.Lys550IleVAR_033123rs28933968
2KITp.Val559AlaVAR_033126
3KITp.Val559AspVAR_033127
4PDGFRAp.Tyr849CysVAR_066474

Clinvar genetic disease variations for Gastrointestinal Stromal Tumor:

1 (show all 14)
id Gene Name Type Significance SNP ID Assembly Location
1SDHBNM_003000.2(SDHB): c.725G> A (p.Arg242His)single nucleotide variantPathogenicrs74315368GRCh37Chr 1, 17349143: 17349143
2PDGFRANM_006206.4(PDGFRA): c.2525A> T (p.Asp842Val)single nucleotide variantPathogenicrs121908585GRCh37Chr 4, 55152093: 55152093
3PDGFRAPDGFRA, 4-CODON DEL, 842DIMHdeletionPathogenic
4PDGFRAPDGFRA, 4-CODON DEL, 845HDSNdeletionPathogenic
5PDGFRANM_006206.4(PDGFRA): c.1682T> A (p.Val561Asp)single nucleotide variantPathogenicrs121908586GRCh37Chr 4, 55141036: 55141036
6PDGFRAPDGFRA, 2-CODON INS, 561ERinsertionPathogenic
7PDGFRAPDGFRA, 5-CODON DEL, 560RVIESdeletionPathogenic
8PDGFRAPDGFRA, 6-CODON DEL, 566SPDGHEdeletionPathogenic
9KITKIT, 6-BP DELdeletionPathogenic
10KITKIT, 15-BP DELdeletionPathogenic
11KITKIT, 15-BP DEL/LYS550ILEdeletionPathogenic
12KITNM_000222.2(KIT): c.1676T> A (p.Val559Asp)single nucleotide variantPathogenicrs121913517GRCh37Chr 4, 55593610: 55593610
13KITKIT, 27-BP DELdeletionPathogenic
14SDHCNM_003001.3(SDHC): c.405+1G> Asingle nucleotide variantPathogenicGRCh37Chr 1, 161326631: 161326631

Expression for genes affiliated with Gastrointestinal Stromal Tumor

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gastrointestinal Stromal Tumor

Search GEO for disease gene expression data for Gastrointestinal Stromal Tumor.

Pathways for genes affiliated with Gastrointestinal Stromal Tumor

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Sources:
50PathCards, 38NCBI BioSystems Database, 30KEGG, 51PharmGKB, 55Reactome, 5Cell Signaling Technology, 53QIAGEN, 12EMD Millipore, 60Thomson Reuters, 61Tocris Bioscience
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Pathways related to Gastrointestinal Stromal Tumor according to GeneCards/GeneDecks:

(show all 35)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2PDGFRB, PDGFRA
2
Show member pathways
L-serine degradation38
pentose phosphate pathway (oxidative branch)38
formaldehyde oxidation II (glutathione-dependent)38
10.1SDHA, SDHC, SDHB
3
Show member pathways
TCA cycle38
pyruvate decarboxylation to acetyl CoA38
NAD phosphorylation and dephosphorylation38
TCA Cycle38
conversion of glucose to acetyl CoA and entry into the TCA cycle38
10.1SDHC, SDHA, SDHB
410.1PDGFRA, ACTC1, KIT
5
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy38
10.0ACTC1, DES, ITGA6
610.0ITGA6, PDGFRB, PDGFRA
710.0PDGFRB, NF2, PDGFRA
8
Show member pathways
10.0ACTC1, VIM, DES
9
Show member pathways
Cytoskeleton remodeling Neurofilaments60
10.0VIM, DES, NES
10
Show member pathways
9.9PDGFRB, KITLG, KIT, PDGFRA
11
Show member pathways
Development EDNRB signaling60
Development ACM2 and ACM4 activation of ERK60
Cell adhesion Integrin inside out signaling60
Development G Proteins mediated regulation MARK ERK signaling60
Signal transduction IP3 signaling60
Development Angiotensin signaling via PYK260
Development EPO induced MAPK pathway60
9.9KITLG, KIT, PDGFRB, PDGFRA
12
Show member pathways
9.9KITLG, PDGFRB, PDGFRA, KIT
13
Show member pathways
9.8KIT, PDGFRB, PDGFRA, FLT3
149.8ACTC1, VIM, DES, NF2
159.7KITLG, KIT, CD34, CSF1R
16
Show member pathways
9.7KIT, PDGFRB, KITLG, PDGFRA, ITGA6
17
Show member pathways
9.7KITLG, KIT, PDGFRB, ITGA6, PDGFRA
18
Show member pathways
9.7KIT, S100B, PDGFRB, KITLG, PDGFRA
19
Show member pathways
9.7PDGFRB, KIT, KITLG, PDGFRA, CSF1R
20
Show member pathways
9.7KITLG, KIT, PDGFRB, PDGFRA, CSF1R
21
Show member pathways
9.7KITLG, KIT, PDGFRB, CSF1R, PDGFRA
22
Show member pathways
9.6KIT, PDGFRB, CD34, KITLG, PDGFRA
239.5PDGFRA, KITLG, KIT, ITGA6, CSF1R, PDGFRB
249.5PDGFRA, PDGFRB, KIT, CSF1R, KITLG, FLT3
25
Show member pathways
9.5PDGFRA, PDGFRB, KIT, KITLG, CSF1R, FLT3
26
Show member pathways
9.5FLT3, CSF1R, PDGFRA, PDGFRB, KIT, KITLG
27
Show member pathways
9.5KIT, KITLG, PDGFRB, CSF1R, FLT3, PDGFRA
28
Show member pathways
9.4KIT, PDGFRB, CSF1R, ITGA6, FLT3, PDGFRA
299.3CD34, ITGA6, CSF1R, KIT, KITLG, FLT3
30
Show member pathways
9.3PDGFRB, FLT3, ITGA6, PDGFRA, KITLG, KIT
31
Show member pathways
9.3ITGA6, CSF1R, PDGFRA, PDGFRB, KIT, KITLG
329.3KIT, PDGFRA, PDGFRB, KITLG, FLT3, CSF1R
33
Show member pathways
9.3KITLG, FLT3, PDGFRA, CSF1R, PDGFRB, KIT
34
Show member pathways
9.0PDGFRB, KIT, KITLG, CSF1R, ETV1, ITGA6
35
Show member pathways
8.9PDGFRB, ITGA6, VIM, FLT3, DES, KIT

Compounds for genes affiliated with Gastrointestinal Stromal Tumor

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Sources:
45Novoseek, 24HMDB, 51PharmGKB, 11DrugBank, 29IUPHAR, 61Tocris Bioscience
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Compounds related to Gastrointestinal Stromal Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 132)
idCompoundScoreTop Affiliating Genes
1monochloroacetic acid4510.2VIM, KITLG, KIT
2pkc 4124510.2FLT3, KIT, PDGFRB, PDGFRA
3orcein4510.2S100B, ACTC1, VIM, DES
4Fumaric acid2410.2SDHB, SDHC, SDHA
5s 1004510.2VIM, DES, ACTC1, S100B
6su54164510.2FLT3, KITLG, KIT, PDGFRB
7ag-12964510.1PDGFRA, KIT, FLT3, PDGFRB, KITLG
8sunitinib45 51 1112.0PDGFRB, CSF1R, KIT, FLT3, PDGFRA
9toluidine4510.0KITLG, KIT, VIM, DES, S100A1
10mucicarmine4510.0ACTC1, S100A1, S100B, DES, VIM
11reticulin4510.0VIM, ACTC1, CD34, S100B, DES
12b 7234510.0ACTC1, DES, VIM, S100B, S100A1
13methylcellulose459.9FLT3, CD34, KITLG, KIT
14cytarabine45 51 1111.8CSF1R, FLT3, KITLG, VIM, KIT
15formaldehyde45 2410.8ACTC1, DES, VIM, KIT, MKI67, S100B
16agarose459.8ITGA6, S100B, KIT, KITLG, FLT3
17biotin45 24 1111.8VIM, KITLG, S100A1, ACTC1, MKI67, DES
18tgf beta1459.8PDGFRB, MKI67, FLT3, VIM, PDGFRA, KITLG
19phosphotyrosine459.7KIT, FLT3, ITGA6, CSF1R, PDGFRA, PDGFRB
20methionine459.7PDGFRB, VIM, S100B, DES, CSF1R, KIT
21bromodeoxyuridine459.7NES, PDGFRB, S100B, KITLG, VIM, MKI67
22paclitaxel45 51 1111.7VIM, MKI67, PDGFRB, KIT, KITLG, S100B
23rapamycin459.7FLT3, VIM, KITLG, PDGFRB, KIT, PDGFRA
24dmso459.6CSF1R, VIM, SDHB, NES, KITLG
25agar459.6CSF1R, VIM, CD34, NF2, PDGFRB, KITLG
26methotrexate51 45 1111.6VIM, MKI67, KIT, ITGA6, KITLG
27doxorubicin45 51 1111.6MKI67, FLT3, KITLG, DES, VIM, KIT
282-methoxyethanol459.6ACTC1, VIM, S100A1
29glycogen45 2410.5SDHB, MKI67, VIM, DES, ACTC1, S100A1
30lactate459.5VIM, DES, MKI67, SDHB, KITLG, KIT
31steroid459.5KIT, KITLG, DES, S100B, CSF1R, ACTC1
32iron45 2410.4S100B, KITLG, S100A1, ACTC1, VIM, SDHA
33thymidine45 2410.4FLT3, PDGFRA, DES, KIT, KITLG, CD34
34hematoxylin459.4DES, S100B, KIT, CD34, MKI67, VIM
35imatinib45 51 1111.4KITLG, KIT, S100B, PDGFRB, PDGFRA, CSF1R
36glucose459.4KIT, S100B, PDGFRB, ACTC1, NES, SDHB
37threonine459.3MKI67, FLT3, CSF1R, PDGFRB, S100B, KIT
38atp45 2910.3SDHB, KIT, S100B, PDGFRB, PDGFRA, CSF1R
39oxygen45 2410.3S100B, DES, KITLG, MKI67, SDHB, SDHC
40oligonucleotide459.3VIM, ITGA6, CSF1R, PDGFRA, PDGFRB, KIT
41cysteine459.2KIT, NF2, VIM, S100B, S100A1, PDGFRB
42testosterone45 61 24 1112.2SDHB, S100B, KIT, KITLG, ACTC1, ETV1
43serine459.0PDGFRB, CSF1R, NF2, KITLG, KIT, S100B
44calcium45 51 24 1111.7PDGFRA, PDGFRB, S100A1, S100B, KIT, KITLG
45estrogen458.6NES, VIM, MKI67, DES, ACTC1, CSF1R
46progesterone45 29 61 24 1112.5VIM, MKI67, CD34, NF2, KIT, S100B
47paraffin458.4VIM, MKI67, NES, ACTC1, DES, CD34
48vegf458.2SDHC, FLT3, VIM, NES, ACTC1, ITGA6
49retinoic acid45 249.1VIM, FLT3, SDHC, MKI67, DES, NES
50tyrosine457.8CSF1R, ITGA6, ACTC1, ETV1, PDGFRA, PDGFRB

GO Terms for genes affiliated with Gastrointestinal Stromal Tumor

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Sources:
16Gene Ontology
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Cellular components related to Gastrointestinal Stromal Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial respiratory chain complex IIGO:00574910.2SDHA, SDHC, SDHB
2intrinsic component of plasma membraneGO:03122610.2PDGFRB, PDGFRA
3external side of plasma membraneGO:0098979.8ITGA6, PDGFRA, KIT, CD34
4intermediate filamentGO:0058829.7NES, VIM, DES
5plasma membraneGO:0058868.8VIM, ITGA6, CSF1R, PDGFRA, PDGFRB, KIT
6cytoplasmGO:0057378.7MKI67, VIM, NES, ACTC1, PDGFRA, PDGFRB

Biological processes related to Gastrointestinal Stromal Tumor according to GeneCards/GeneDecks:

(show all 38)
idNameGO IDScoreTop Affiliating Genes
1metanephric glomerular capillary formationGO:07227710.5PDGFRA, PDGFRB
2positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathwayGO:03809110.5PDGFRA, PDGFRB
3tricarboxylic acid cycleGO:00609910.5SDHB, SDHC, SDHA
4retina vasculature development in camera-type eyeGO:06129810.5PDGFRA, PDGFRB
5ectopic germ cell programmed cell deathGO:03523410.5KIT, KITLG
6positive regulation of phospholipase C activityGO:01086310.5PDGFRA, PDGFRB, KIT
7myeloid progenitor cell differentiationGO:00231810.4FLT3, KIT
8succinate metabolic processGO:00610510.4SDHB, SDHA
9cardiac myofibril assemblyGO:05500310.4ACTC1, PDGFRA, PDGFRB
10cell chemotaxisGO:06032610.4PDGFRA, PDGFRB, KIT
11regulation of actin cytoskeleton reorganizationGO:200024910.4CSF1R, PDGFRA
12stem cell proliferationGO:07208910.4NES, CD34
13muscle filament slidingGO:03004910.4ACTC1, VIM, DES
14odontogenesis of dentin-containing toothGO:04247510.3NF2, PDGFRA, ITGA6
15respiratory electron transport chainGO:02290410.3SDHA, SDHC, SDHB
16positive regulation of MAP kinase activityGO:04340610.3KITLG, PDGFRB, FLT3
17phosphatidylinositol metabolic processGO:04648810.3PDGFRB, CSF1R
18positive regulation of phosphatidylinositol 3-kinase activityGO:04355210.3KIT, PDGFRB, PDGFRA, FLT3
19positive regulation of phosphatidylinositol 3-kinase signalingGO:01406810.2KIT, PDGFRB, PDGFRA, FLT3
20fibroblast growth factor receptor signaling pathwayGO:00854310.2KITLG, KIT, PDGFRB, PDGFRA
21Fc-epsilon receptor signaling pathwayGO:03809510.2PDGFRA, PDGFRB, KIT, KITLG
22epidermal growth factor receptor signaling pathwayGO:00717310.2KITLG, KIT, PDGFRB, PDGFRA
23positive regulation of cell migrationGO:03033510.2KIT, PDGFRB, PDGFRA, CSF1R
24embryonic hemopoiesisGO:03516210.2KITLG, KIT
25cellular metabolic processGO:04423710.2SDHA, SDHC, SDHB
26neurotrophin TRK receptor signaling pathwayGO:04801110.1KITLG, KIT, PDGFRB, PDGFRA
27positive regulation of ERK1 and ERK2 cascadeGO:07037410.1CSF1R, PDGFRA, PDGFRB
28phosphatidylinositol-mediated signalingGO:04801510.1KITLG, KIT, PDGFRB, PDGFRA, CSF1R
29hemopoiesisGO:03009710.1CD34, KIT, CSF1R, FLT3
30regulation of cell shapeGO:00836010.1KIT, S100B, CSF1R
31cellular response to cytokine stimulusGO:07134510.0FLT3, CSF1R
32peptidyl-tyrosine phosphorylationGO:01810810.0FLT3, CSF1R, PDGFRA, PDGFRB, KIT
33protein autophosphorylationGO:04677710.0FLT3, CSF1R, PDGFRA, PDGFRB, KIT
34tissue homeostasisGO:00189410.0PDGFRB, CD34
35aerobic respirationGO:0090609.9SDHC, SDHB
36innate immune responseGO:0450879.9CSF1R, PDGFRA, PDGFRB, S100B, KIT, KITLG
37cell proliferationGO:0082839.8MKI67, CSF1R, S100B, KITLG, CD34
38positive regulation of cell proliferationGO:0082849.8FLT3, CSF1R, PDGFRA, PDGFRB, S100B, KIT

Molecular functions related to Gastrointestinal Stromal Tumor according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1succinate dehydrogenase (ubiquinone) activityGO:00817710.5SDHA, SDHB
2succinate dehydrogenase activityGO:00010410.4SDHA, SDHC
3vascular endothelial growth factor bindingGO:03808510.4PDGFRB, PDGFRA
4vascular endothelial growth factor-activated receptor activityGO:00502110.2FLT3, PDGFRA
5transmembrane receptor protein tyrosine kinase activityGO:00471410.2FLT3, PDGFRA, KIT
6platelet-derived growth factor bindingGO:04840710.2PDGFRB, PDGFRA
7S100 protein bindingGO:04454810.1S100B, S100A1
8phosphatidylinositol 3-kinase bindingGO:04354810.1PDGFRB, FLT3
9platelet-derived growth factor receptor bindingGO:00516110.1PDGFRA, PDGFRB
10cytokine bindingGO:0199559.8KIT, CSF1R
11protein homodimerization activityGO:0428039.6FLT3, CSF1R, PDGFRA, S100A1, S100B, KIT
12ATP bindingGO:0055249.4MKI67, FLT3, ACTC1, CSF1R, PDGFRA, PDGFRB
13protein bindingGO:0055158.1NF2, DES, MKI67, SDHB, SDHA, FLT3

Products for genes affiliated with Gastrointestinal Stromal Tumor

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gastrointestinal Stromal Tumor

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet