GANT
MCID: GST019
MIFTS: 83

Gastrointestinal Stromal Tumor (GANT) malady

Genetic diseases, Rare diseases, Gastrointestinal diseases, Cancer diseases categories

Summaries for Gastrointestinal Stromal Tumor

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OMIM:46 Gastrointestinal stromal tumors are mesenchymal tumors found in the gastrointestinal tract that originate from the... (606764) more...

MalaCards based summary: Gastrointestinal Stromal Tumor, also known as gastrointestinal stromal sarcoma, is related to neurofibromatosis and desmoid tumor, and has symptoms including neoplasm of the stomach, sarcoma and nausea and vomiting. An important gene associated with Gastrointestinal Stromal Tumor is SDHB (succinate dehydrogenase complex, subunit B, iron sulfur (Ip)), and among its related pathways are Osteoblast Signaling and Carbon metabolism. The compounds monochloroacetic acid and pkc 412 have been mentioned in the context of this disorder. Affiliated tissues include small intestine, colon and liver, and related mouse phenotypes are limbs/digits/tail and hearing/vestibular/ear.

Genetics Home Reference:22 A gastrointestinal stromal tumor (GIST) is a type of tumor that occurs in the gastrointestinal tract, most commonly in the stomach or small intestine. The tumors are thought to grow from specialized cells found in the gastrointestinal tract called interstitial cells of Cajal (ICCs) or precursors to these cells. GISTs are usually found in adults between ages 40 and 70; rarely, children and young adults develop these tumors. The tumors can be cancerous (malignant) or noncancerous (benign).

NIH Rare Diseases:42 Gastrointestinal stromal tumors are a type of soft tissue sarcoma (tumor) that usually begins in cells in the wall of the stomach, intestines, or rectum. these tumors may be noncancerous or cancerous. they can affect adults, adolescents, or children.  it is estimated that around 5,000 new cases of gastrointestinal stromal tumors are diagnosed in the united states each year. last updated: 4/27/2010

Wikipedia:64 Gastrointestinal stromal tumors (GISTs) are the most common[citation needed]mesenchymal tumors of the... more...

Aliases & Classifications for Gastrointestinal Stromal Tumor

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Sources:
9Disease Ontology, 10diseasecard, 42NIH Rare Diseases, 21GeneTests, 23GTR, 22Genetics Home Reference, 46OMIM, 11DISEASES, 44Novoseek, 48Orphanet, 61UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 35MESH via Orphanet, 27ICD10 via Orphanet, 62UMLS via Orphanet
See all sources

Gastrointestinal Stromal Tumor, Aliases & Descriptions:

Name: Gastrointestinal Stromal Tumor 9 10 22 46 11 44 48
Gastrointestinal Stromal Sarcoma 42 22 48 61
Gastrointestinal Stromal Tumors 42 21 23 61
Gist 9 42 22 48
 
Stromal Tumor of Gastrointestinal Tract 9 61
Gastrointestinal Stromal Neoplasm 22 61
Gant 9


Classifications:



Characteristics (Orphanet epidemiological data):

48
gastrointestinal stromal tumor:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Adulthood


External Ids:

Disease Ontology9 DOID:9253
MeSH34 D046152
NCIt39 C3868
OMIM46 606764
MESH via Orphanet35 D046152
ICD10 via Orphanet27 C26.9
UMLS via Orphanet62 C0238198

Related Diseases for Gastrointestinal Stromal Tumor

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Diseases in the Gastrointestinal Stromal Tumor family:

Gastrointestinal Stromal Tumor, Familial

Diseases related to Gastrointestinal Stromal Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 274)
idRelated DiseaseScoreTop Affiliating Genes
1neurofibromatosis31.5NF2, SDHB
2desmoid tumor31.3KIT, PDGFRB, PDGFRA, ACTC1, DES
3fibromatosis31.3CD34, KIT, S100A1, PDGFRB, ACTC1, VIM
4acute myeloid leukemia31.1KIT, FLT3
5leiomyoma31.1CD34, KIT, S100B, S100A1, PDGFRA, ACTC1
6myeloid leukemia31.1CD34, KITLG, KIT, CSF1R, FLT3
7adenosarcoma31.1ACTC1, DES
8granular cell tumor31.0S100B, S100A1, VIM, DES
9leiomyosarcoma31.0CD34, KIT, S100B, S100A1, PDGFRB, PDGFRA
10adenocarcinoma31.0CD34, NF2, KITLG, PDGFRB, CSF1R, ITGA6
11urticaria pigmentosa31.0KITLG, KIT
12perineurioma30.9CD34, S100B, VIM
13refractory anemia30.9KITLG, KIT, FLT3
14leukemia30.9CD34, KITLG, KIT, PDGFRB, PDGFRA, CSF1R
15mastocytosis30.9KITLG, KIT, PDGFRB, PDGFRA
16angiosarcoma30.8CD34, PDGFRA, ACTC1, VIM
17adenoma30.8KITLG, S100A1, ITGA6, ACTC1, NES, MKI67
18endometriosis30.8PDGFRA, ITGA6, ACTC1
19carney triad30.7KIT, PDGFRA, SDHC, SDHB
20osteosarcoma30.7NF2, PDGFRB, PDGFRA, CSF1R
21malignant peripheral nerve sheath tumor30.7CD34, NF2, KIT, S100B, S100A1, PDGFRA
22hemangiopericytoma30.6CD34, S100B, S100A1, ACTC1, VIM, DES
23chronic myeloid leukemia30.6CD34, KITLG, KIT, PDGFRB, PDGFRA, FLT3
24colorectal cancer30.6CD34, NF2, KITLG, PDGFRB, PDGFRA
25ovarian cancer30.6CD34, NF2, PDGFRB, PDGFRA, CSF1R
26synovial sarcoma30.6KIT, S100B, NES, VIM, MKI67, DES
27smooth muscle tumor30.5KIT, S100B, S100A1, ACTC1, VIM, MKI67
28burkitt's lymphoma30.5CD34, S100A1, CSF1R, ACTC1, FLT3, MKI67
29paraganglioma and gastric stromal sarcoma30.5SDHC, SDHB
30myelodysplastic syndromes30.5CD34, KITLG, KIT, PDGFRB, PDGFRA, CSF1R
31meningioma30.4CD34, NF2, S100B, S100A1, PDGFRB, VIM
32dermatofibrosarcoma protuberans30.4CD34, KIT, S100B, S100A1, PDGFRB, ACTC1
33breast cancer30.4NF2, S100A1, CSF1R, ITGA6, ACTC1, VIM
34sarcoma30.3CD34, NF2, KITLG, KIT, S100B, S100A1
35paraganglioma30.3KIT, S100B, S100A1, SDHA, SDHC, SDHB
36chondroma30.2PDGFRA, SDHC, SDHB
37neurofibroma30.2CD34, NF2, KITLG, KIT, S100B, S100A1
38multiple endocrine neoplasia30.2NF2, SDHC, SDHB
39multiple endocrine neoplasia type 2a30.1SDHC, SDHB
40melanoma29.9CD34, NF2, KITLG, KIT, S100B, S100A1
41duodenitis10.8
42esophagitis10.7
43pancreatitis10.7
44infantile myofibromatosis10.6DES
45fibrous histiocytoma10.6CD34
46mixed glioma10.6PDGFRA
47rosai-dorfman disease10.6S100B
48histiocytosis10.6S100B
49ganglioglioma10.6S100B
50papilloma10.6ACTC1

Graphical network of the top 20 diseases related to Gastrointestinal Stromal Tumor:



Diseases related to gastrointestinal stromal tumor

Symptoms for Gastrointestinal Stromal Tumor

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Symptoms by clinical synopsis from OMIM:

606764

Clinical features from OMIM:

606764

Symptoms:

 48 (show all 18)
  • estomach/gastric neoplasm/tumor/carcinoma/cancer
  • sarcoma
  • feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • constipation
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • intestinal obstruction/ileus
  • intestinal perforation
  • asthenia/fatigue/weakness
  • cutaneous rash
  • irregular/in bands/reticular skin hyperpigmentation
  • hepatitis/icterus/cholestasis
  • anaemia
  • digestive neoplasm/tumor/carcinoma/cancer
  • esophageal neoplasm/tumor/carcinoma/cancer
  • small bowel neoplasm/tumor/carcinoma/cancer
  • colon neoplasm/tumor/carcinoma/cancer
  • rectum/rectal neoplasm/tumor/carcinoma/cancer

HPO human phenotypes related to Gastrointestinal Stromal Tumor:

(show all 25)
id Description Frequency HPO Source Accession
1 neoplasm of the stomach hallmark (90%) HP:0006753
2 sarcoma hallmark (90%) HP:0100242
3 nausea and vomiting typical (50%) HP:0002017
4 constipation typical (50%) HP:0002019
5 gastrointestinal hemorrhage typical (50%) HP:0002239
6 intestinal obstruction typical (50%) HP:0005214
7 feeding difficulties in infancy typical (50%) HP:0008872
8 skin rash occasional (7.5%) HP:0000988
9 abnormality of the liver occasional (7.5%) HP:0001392
10 anemia occasional (7.5%) HP:0001903
11 irregular hyperpigmentation occasional (7.5%) HP:0007400
12 neoplasm of the colon occasional (7.5%) HP:0100273
13 neoplasm of the rectum occasional (7.5%) HP:0100743
14 esophageal neoplasm occasional (7.5%) HP:0100751
15 neoplasm of the small intestine occasional (7.5%) HP:0100833
16 autosomal dominant inheritance HP:0000006
17 hyperpigmentation of the skin HP:0000953
18 urticaria HP:0001025
19 neurofibromas HP:0001067
20 large hands HP:0001176
21 dysphagia HP:0002015
22 constipation HP:0002019
23 sporadic HP:0003745
24 intestinal obstruction HP:0005214
25 gastrointestinal stroma tumor HP:0100723

Drugs & Therapeutics for Gastrointestinal Stromal Tumor

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Drug clinical trials:

Search ClinicalTrials for Gastrointestinal Stromal Tumor

Search NIH Clinical Center for Gastrointestinal Stromal Tumor

Genetic Tests for Gastrointestinal Stromal Tumor

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Genetic tests related to Gastrointestinal Stromal Tumor:

id Genetic test Affiliating Genes
1 Gastrointestinal Stromal Tumor21 PDGFRA
2 Gastrointestinal Stromal Tumors23

Anatomical Context for Gastrointestinal Stromal Tumor

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MalaCards organs/tissues related to Gastrointestinal Stromal Tumor:

32
Small intestine, Colon, Liver, Bone, Skin, Pancreas, Lymph node, Prostate, Smooth muscle, Endothelial, Testes, Myeloid, Appendix, Brain, Thyroid, Breast, Bone marrow, Spleen, Heart, Skeletal muscle, Ovary, Uterus, T cells, B cells, Tongue, Neutrophil

Animal Models for Gastrointestinal Stromal Tumor or affiliated genes

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MGI Mouse Phenotypes related to Gastrointestinal Stromal Tumor:

36 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.7KITLG, KIT, PDGFRA, CSF1R, ITGA6
2MP:00053779.6ITGA6, CSF1R, KIT, KITLG, NF2
3MP:00053829.5ITGA6, CSF1R, PDGFRA, PDGFRB, KIT, KITLG
4MP:00020069.5FLT3, ITGA6, PDGFRA, KIT, KITLG, NF2
5MP:00053919.5SDHC, VIM, ITGA6, PDGFRB, KIT, KITLG
6MP:00053699.4DES, VIM, ETV1, ACTC1, PDGFRA, PDGFRB
7MP:00053809.4VIM, NES, ITGA6, PDGFRA, PDGFRB, KIT
8MP:00053799.4ITGA6, CSF1R, PDGFRA, PDGFRB, KIT, KITLG
9MP:00053859.2DES, VIM, ACTC1, ITGA6, PDGFRA, PDGFRB
10MP:00107719.2ITGA6, CSF1R, PDGFRA, PDGFRB, S100B, KIT
11MP:00028739.1ETV1, ACTC1, PDGFRA, PDGFRB, S100A1, S100B
12MP:00036319.1VIM, NES, ETV1, ITGA6, PDGFRA, PDGFRB
13MP:00053979.0FLT3, VIM, ITGA6, CSF1R, PDGFRA, PDGFRB
14MP:00053899.0VIM, CSF1R, PDGFRA, PDGFRB, KIT, KITLG
15MP:00053868.9DES, VIM, NES, ETV1, CSF1R, PDGFRA
16MP:00053878.9CSF1R, ITGA6, VIM, FLT3, PDGFRA, PDGFRB
17MP:00053768.8DES, FLT3, VIM, ACTC1, CSF1R, PDGFRA
18MP:00053788.7ACTC1, ETV1, NES, VIM, FLT3, ITGA6
19MP:00053848.6ACTC1, ETV1, NES, VIM, FLT3, ITGA6
20MP:00107688.4NF2, DES, SDHC, FLT3, VIM, NES

Publications for Gastrointestinal Stromal Tumor

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Articles related to Gastrointestinal Stromal Tumor:

(show top 50)    (show all 1130)
idTitleAuthorsYear
1
Chromosomal aberrations in primary PDGFRA-mutated gastrointestinal stromal tumors. (24157063)
2014
2
Angiomatous leiomyoma of the urachus: A rare entity masquerading as extraluminal gastrointestinal stromal tumor. (24049386)
2013
3
Single-incision laparoscopic and endoscopic cooperative surgery for gastrointestinal stromal tumor arising from the duodenum. (24308591)
2013
4
Gastrointestinal stromal tumor of small intestine and synchronous bilateral papillary renal cell carcinoma. (24195178)
2013
5
Gastrointestinal stromal tumor: an unusual cause of gastrointestinal bleeding. (23633157)
2013
6
Dedifferentiation in gastrointestinal stromal tumor to an anaplastic KIT-negative phenotype: a diagnostic pitfall: morphologic and molecular characterization of 8 cases occurring either de novo or after imatinib therapy. (23348204)
2013
7
Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147) is associated with low survival in patients with gastrointestinal stromal tumors (GISTs). (22281667)
2012
8
Surgical treatment of a giant mesenteric fibromatosis mimicking a gastrointestinal stromal tumor: a case report and current treatment aspects. (23175930)
2012
9
GLP-2 receptors in human disease: high expression in gastrointestinal stromal tumors and Crohn's disease. (22951144)
2012
10
A Case of KIT-Negative Extra-Gastrointestinal Stromal Tumor of the Lesser Omentum. (22855655)
2012
11
Multifocal gastric gastrointestinal stromal tumors (GISTs) with lymph node metastases in children and young adults: a comparative clinical and histomorphological study of three cases including a new case of Carney triad. (21663639)
2011
12
Synchronous double tumor of breast cancer and gastrointestinal stromal tumor in a patient with neurofibromatosis type 1: report of a case. (22199319)
2011
13
Frequency, phenotype, and genotype of minute gastrointestinal stromal tumors in the stomach: an autopsy study. (21658742)
2011
14
Gastrointestinal stromal tumor presenting as dyspareunia. (22234771)
2011
15
CT features, mimics and atypical presentations of gastrointestinal stromal tumor (GIST). (22013291)
2011
16
Recurring gastrointestinal stromal tumor with splenic metastasis. (22319733)
2011
17
Unusual metastases of gastrointestinal stromal tumor and genotypic correlates: Case report and review of the literature. (22811827)
2011
18
Comparison of RECIST and Choi criteria for computed tomographic response evaluation in patients with advanced gastrointestinal stromal tumor treated with sunitinib. (21289369)
2011
19
First report of connexin 43-positive gastrointestinal stromal tumor (GIST). (21462830)
2010
20
Detection of treatment-induced changes in signaling pathways in gastrointestinal stromal tumors using transcriptomic data. (19903850)
2009
21
Kinase mutations and efficacy of imatinib in Korean patients with advanced gastrointestinal stromal tumors. (19411681)
2009
22
Aberrations of chromosome 13q in gastrointestinal stromal tumors: analysis of 91 cases by fluorescence in situ hybridization (FISH). (19430298)
2009
23
Expression of CD117, CD34, SMA, S-100 protein, Vim and desmin in patients with gastrointestinal stromal tumors]. (18359707)
2008
24
PDGFRalpha gene mutation and protein expression in gastrointestinal stromal tumors. (18547963)
2008
25
Gastrointestinal stromal tumors: past, present, and future. (18648736)
2008
26
Site-dependent differential KIT and PDGFRA expression in gastric and intestinal gastrointestinal stromal tumors. (17673922)
2007
27
Gastrointestinal Stromal Tumors (GIST) and Their Management. (19360154)
2007
28
Imatinib in gastrointestinal stromal tumor treatment--results from University Hospital Centre Zagreb]. (16910417)
2006
29
Gastrointestinal stromal tumors express the orexigen ghrelin. (16954444)
2006
30
Malignant gastrointestinal stromal tumor of the ampulla of Vater presenting with obstructive jaundice. (16855323)
2006
31
Interobserver variability in histologic recognition, interpretation of KIT immunostaining, and determining MIB-1 labeling indices in gastrointestinal stromal tumors and other spindle cell tumors of the gastrointestinal tract. (16540730)
2006
32
Polyclonal evolution of multiple secondary KIT mutations in gastrointestinal stromal tumors under treatment with imatinib mesylate. (16551858)
2006
33
A long-term survival case with multiple liver metastases from duodenal gastrointestinal stromal tumor that was drastically reduced by the treatment with imatinib]. (16315926)
2005
34
Hypoxia-inducible factor-1alpha is associated with risk of aggressive behavior and tumor angiogenesis in gastrointestinal stromal tumor. (15845570)
2005
35
Serum KIT and KIT ligand levels in patients with gastrointestinal stromal tumors treated with imatinib. (15070666)
2004
36
Current clinical management of gastrointestinal stromal tumors. (15270663)
2004
37
Malignant gastrointestinal stromal tumor originating in the lesser omentum, complicated by rapidly progressive glomerulonephritis and gastric carcinoma. (15005250)
2004
38
A new mutation in the KIT ATP pocket causes acquired resistance to imatinib in a gastrointestinal stromal tumor patient. (15236194)
2004
39
Gastrointestinal stromal tumors in a mouse model by targeted mutation of the Kit receptor tyrosine kinase. (12754375)
2003
40
PDGFRA activating mutations in gastrointestinal stromal tumors. (12522257)
2003
41
Secondary amyloidosis and gastrointestinal stromal tumors. A case report and discussion of pathogenesis. (12683877)
2003
42
Prognostic predictors of gastrointestinal stromal tumors: a multi-institutional analysis of 102 patients with definition of a prognostic index. (12875864)
2003
43
Hypoxia-inducible factor-1alpha expression and angiogenesis in gastrointestinal stromal tumor of the stomach. (12792726)
2003
44
Approval summary: imatinib mesylate in the treatment of metastatic and/or unresectable malignant gastrointestinal stromal tumors. (12374669)
2002
45
Germline-activating mutation in the kinase domain of KIT gene in familial gastrointestinal stromal tumors. (11073817)
2000
46
Specific mutation in exon 11 of c-kit proto-oncogene in a malignant gastrointestinal stromal tumor of the rectum. (11063223)
2000
47
C-kit gene abnormalities in gastrointestinal stromal tumors (tumors of interstitial cells of Cajal. (10665649)
1999
48
Mutations of c-kit JM domain are found in a minority of human gastrointestinal stromal tumors. (10086344)
1999
49
Interstitial cells of Cajal as precursors of gastrointestinal stromal tumors. (10199467)
1999
50
The gastric hypercellular microleiomyoma as a precursor lesion for clinical gastrointestinal stromal tumors. (9416690)
1997

Variations for Gastrointestinal Stromal Tumor

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UniProtKB/Swiss-Prot genetic disease variations for Gastrointestinal Stromal Tumor:

63
id Symbol AA change Variation ID SNP ID
1KITp.Lys550IleVAR_033123rs28933968
2KITp.Val559AlaVAR_033126
3KITp.Val559AspVAR_033127
4PDGFRAp.Tyr849CysVAR_066474

Clinvar genetic disease variations for Gastrointestinal Stromal Tumor:

7 (show all 14)
id Gene Name Type Significance SNP ID Assembly Location
1SDHBNM_003000.2(SDHB): c.725G> A (p.Arg242His)single nucleotide variantPathogenicrs74315368GRCh37Chr 1, 17349143: 17349143
2PDGFRANM_006206.4(PDGFRA): c.2525A> T (p.Asp842Val)single nucleotide variantPathogenicrs121908585GRCh37Chr 4, 55152093: 55152093
3PDGFRAPDGFRA, 4-CODON DEL, 842DIMHdeletionPathogenic
4PDGFRAPDGFRA, 4-CODON DEL, 845HDSNdeletionPathogenic
5PDGFRANM_006206.4(PDGFRA): c.1682T> A (p.Val561Asp)single nucleotide variantPathogenicrs121908586GRCh37Chr 4, 55141036: 55141036
6PDGFRAPDGFRA, 2-CODON INS, 561ERinsertionPathogenic
7PDGFRAPDGFRA, 5-CODON DEL, 560RVIESdeletionPathogenic
8PDGFRAPDGFRA, 6-CODON DEL, 566SPDGHEdeletionPathogenic
9KITKIT, 6-BP DELdeletionPathogenic
10KITKIT, 15-BP DELdeletionPathogenic
11KITKIT, 15-BP DEL/LYS550ILEdeletionPathogenic
12KITNM_000222.2(KIT): c.1676T> A (p.Val559Asp)single nucleotide variantPathogenicrs121913517GRCh37Chr 4, 55593610: 55593610
13KITKIT, 27-BP DELdeletionPathogenic
14SDHCNM_003001.3(SDHC): c.405+1G> Asingle nucleotide variantPathogenicGRCh37Chr 1, 161326631: 161326631

Expression for genes affiliated with Gastrointestinal Stromal Tumor

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Expression patterns in normal tissues for genes affiliated with Gastrointestinal Stromal Tumor

Search GEO for disease gene expression data for Gastrointestinal Stromal Tumor.

Pathways for genes affiliated with Gastrointestinal Stromal Tumor

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Pathways related to Gastrointestinal Stromal Tumor according to GeneCards/GeneDecks:

(show all 35)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2PDGFRA, PDGFRB
2
Show member pathways
L-serine degradation37
pentose phosphate pathway (oxidative branch)37
formaldehyde oxidation II (glutathione-dependent)37
10.1SDHA, SDHC, SDHB
3
Show member pathways
TCA cycle37
pyruvate decarboxylation to acetyl CoA37
NAD phosphorylation and dephosphorylation37
TCA Cycle37
conversion of glucose to acetyl CoA and entry into the TCA cycle37
10.1SDHA, SDHC, SDHB
410.1KIT, PDGFRA, ACTC1
5
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy37
10.0ITGA6, ACTC1, DES
610.0ITGA6, PDGFRA, PDGFRB
710.0PDGFRA, PDGFRB, NF2
8
Show member pathways
10.0DES, VIM, ACTC1
9
Show member pathways
Cytoskeleton remodeling Neurofilaments59
10.0NES, VIM, DES
10
Show member pathways
Development EDNRB signaling59
Development ACM2 and ACM4 activation of ERK59
Cell adhesion Integrin inside out signaling59
Development G Proteins mediated regulation MARK ERK signaling59
Signal transduction IP3 signaling59
Development Angiotensin signaling via PYK259
Development EPO induced MAPK pathway59
9.9PDGFRA, PDGFRB, KIT, KITLG
11
Show member pathways
9.9PDGFRA, PDGFRB, KIT, KITLG
12
Show member pathways
9.9PDGFRA, PDGFRB, KIT, KITLG
13
Show member pathways
9.8KIT, PDGFRB, PDGFRA, FLT3
149.8DES, VIM, ACTC1, NF2
159.7CSF1R, KIT, KITLG, CD34
16
Show member pathways
9.7KITLG, KIT, PDGFRB, PDGFRA, ITGA6
17
Show member pathways
9.7ITGA6, PDGFRA, PDGFRB, KIT, KITLG
18
Show member pathways
9.7PDGFRA, PDGFRB, S100B, KIT, KITLG
19
Show member pathways
9.7CSF1R, PDGFRA, PDGFRB, KIT, KITLG
20
Show member pathways
9.7CSF1R, PDGFRA, PDGFRB, KIT, KITLG
21
Show member pathways
9.7CSF1R, PDGFRA, PDGFRB, KIT, KITLG
22
Show member pathways
9.6PDGFRA, PDGFRB, KIT, KITLG, CD34
239.5ITGA6, CSF1R, PDGFRA, PDGFRB, KIT, KITLG
24
Show member pathways
9.5FLT3, CSF1R, PDGFRA, PDGFRB, KIT, KITLG
25
Show member pathways
9.5FLT3, CSF1R, PDGFRA, PDGFRB, KIT, KITLG
26
Show member pathways
9.5FLT3, CSF1R, PDGFRA, PDGFRB, KIT, KITLG
279.5FLT3, CSF1R, PDGFRA, PDGFRB, KIT, KITLG
28
Show member pathways
9.4FLT3, ITGA6, CSF1R, PDGFRA, PDGFRB, KIT
299.3CD34, KITLG, KIT, CSF1R, ITGA6, FLT3
30
Show member pathways
9.3FLT3, ITGA6, CSF1R, PDGFRA, PDGFRB, KIT
31
Show member pathways
9.3FLT3, ITGA6, CSF1R, PDGFRA, PDGFRB, KIT
329.3FLT3, ITGA6, CSF1R, PDGFRA, PDGFRB, KIT
33
Show member pathways
9.3FLT3, VIM, CSF1R, PDGFRA, PDGFRB, KIT
34
Show member pathways
9.0FLT3, ETV1, ITGA6, CSF1R, PDGFRA, PDGFRB
35
Show member pathways
8.9DES, FLT3, VIM, ITGA6, CSF1R, PDGFRA

Compounds for genes affiliated with Gastrointestinal Stromal Tumor

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Compounds related to Gastrointestinal Stromal Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 132)
idCompoundScoreTop Affiliating Genes
1monochloroacetic acid4410.2VIM, KITLG, KIT
2pkc 4124410.2FLT3, KIT, PDGFRB, PDGFRA
3orcein4410.2S100B, ACTC1, VIM, DES
4Fumaric acid2510.2SDHB, SDHC, SDHA
5s 1004410.2VIM, DES, ACTC1, S100B
6su54164410.2FLT3, KITLG, KIT, PDGFRB
7ag-12964410.1PDGFRA, KIT, FLT3, PDGFRB, KITLG
8sunitinib44 50 1212.0PDGFRB, CSF1R, KIT, FLT3, PDGFRA
9toluidine4410.0KITLG, KIT, VIM, DES, S100A1
10mucicarmine4410.0ACTC1, S100A1, S100B, DES, VIM
11reticulin4410.0VIM, ACTC1, CD34, S100B, DES
12b 7234410.0ACTC1, DES, VIM, S100B, S100A1
13methylcellulose449.9FLT3, CD34, KITLG, KIT
14cytarabine44 50 1211.8CSF1R, FLT3, KITLG, VIM, KIT
15formaldehyde44 2510.8ACTC1, DES, VIM, KIT, MKI67, S100B
16agarose449.8ITGA6, S100B, KIT, KITLG, FLT3
17biotin44 25 1211.8VIM, KITLG, S100A1, ACTC1, MKI67, DES
18tgf beta1449.8PDGFRB, MKI67, FLT3, VIM, PDGFRA, KITLG
19phosphotyrosine449.7KIT, FLT3, ITGA6, CSF1R, PDGFRA, PDGFRB
20methionine449.7PDGFRB, VIM, S100B, DES, CSF1R, KIT
21bromodeoxyuridine449.7NES, PDGFRB, S100B, KITLG, VIM, MKI67
22paclitaxel44 50 1211.7VIM, MKI67, PDGFRB, KIT, KITLG, S100B
23rapamycin449.7FLT3, VIM, KITLG, PDGFRB, KIT, PDGFRA
24dmso449.6CSF1R, VIM, SDHB, NES, KITLG
25agar449.6CSF1R, VIM, CD34, NF2, PDGFRB, KITLG
26methotrexate50 44 1211.6VIM, MKI67, KIT, ITGA6, KITLG
27doxorubicin44 50 1211.6MKI67, FLT3, KITLG, DES, VIM, KIT
282-methoxyethanol449.6ACTC1, VIM, S100A1
29glycogen44 2510.5SDHB, MKI67, VIM, DES, ACTC1, S100A1
30lactate449.5VIM, DES, MKI67, SDHB, KITLG, KIT
31steroid449.5KIT, KITLG, DES, S100B, CSF1R, ACTC1
32iron44 2510.4S100B, KITLG, S100A1, ACTC1, VIM, SDHA
33thymidine44 2510.4FLT3, PDGFRA, DES, KIT, KITLG, CD34
34hematoxylin449.4DES, S100B, KIT, CD34, MKI67, VIM
35imatinib44 50 1211.4KITLG, KIT, S100B, PDGFRB, PDGFRA, CSF1R
36glucose449.4KIT, S100B, PDGFRB, ACTC1, NES, SDHB
37threonine449.3MKI67, FLT3, CSF1R, PDGFRB, S100B, KIT
38atp44 2910.3SDHB, KIT, S100B, PDGFRB, PDGFRA, CSF1R
39oxygen44 2510.3S100B, DES, KITLG, MKI67, SDHB, SDHC
40oligonucleotide449.3VIM, ITGA6, CSF1R, PDGFRA, PDGFRB, KIT
41cysteine449.2KIT, NF2, VIM, S100B, S100A1, PDGFRB
42testosterone44 60 25 1212.2SDHB, S100B, KIT, KITLG, ACTC1, ETV1
43serine449.0PDGFRB, CSF1R, NF2, KITLG, KIT, S100B
44calcium44 50 25 1211.7PDGFRA, PDGFRB, S100A1, S100B, KIT, KITLG
45estrogen448.6NES, VIM, MKI67, DES, ACTC1, CSF1R
46progesterone44 29 60 25 1212.5VIM, MKI67, CD34, NF2, KIT, S100B
47paraffin448.4VIM, MKI67, NES, ACTC1, DES, CD34
48vegf448.2SDHC, FLT3, VIM, NES, ACTC1, ITGA6
49retinoic acid44 259.1VIM, FLT3, SDHC, MKI67, DES, NES
50tyrosine447.8CSF1R, ITGA6, ACTC1, ETV1, PDGFRA, PDGFRB

GO Terms for genes affiliated with Gastrointestinal Stromal Tumor

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Cellular components related to Gastrointestinal Stromal Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial respiratory chain complex IIGO:00574910.2SDHA, SDHC, SDHB
2intrinsic component of plasma membraneGO:03122610.2PDGFRB, PDGFRA
3external side of plasma membraneGO:0098979.8ITGA6, PDGFRA, KIT, CD34
4intermediate filamentGO:0058829.7NES, VIM, DES
5plasma membraneGO:0058868.8VIM, ITGA6, CSF1R, PDGFRA, PDGFRB, KIT
6cytoplasmGO:0057378.7MKI67, VIM, NES, ACTC1, PDGFRA, PDGFRB

Biological processes related to Gastrointestinal Stromal Tumor according to GeneCards/GeneDecks:

(show all 38)
idNameGO IDScoreTop Affiliating Genes
1metanephric glomerular capillary formationGO:07227710.5PDGFRA, PDGFRB
2positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathwayGO:03809110.5PDGFRA, PDGFRB
3tricarboxylic acid cycleGO:00609910.5SDHB, SDHC, SDHA
4retina vasculature development in camera-type eyeGO:06129810.5PDGFRA, PDGFRB
5ectopic germ cell programmed cell deathGO:03523410.5KIT, KITLG
6positive regulation of phospholipase C activityGO:01086310.5PDGFRA, PDGFRB, KIT
7myeloid progenitor cell differentiationGO:00231810.4FLT3, KIT
8succinate metabolic processGO:00610510.4SDHB, SDHA
9cardiac myofibril assemblyGO:05500310.4ACTC1, PDGFRA, PDGFRB
10cell chemotaxisGO:06032610.4PDGFRA, PDGFRB, KIT
11regulation of actin cytoskeleton reorganizationGO:200024910.4CSF1R, PDGFRA
12stem cell proliferationGO:07208910.4NES, CD34
13muscle filament slidingGO:03004910.4ACTC1, VIM, DES
14odontogenesis of dentin-containing toothGO:04247510.3NF2, PDGFRA, ITGA6
15respiratory electron transport chainGO:02290410.3SDHA, SDHC, SDHB
16positive regulation of MAP kinase activityGO:04340610.3KITLG, PDGFRB, FLT3
17phosphatidylinositol metabolic processGO:04648810.3PDGFRB, CSF1R
18positive regulation of phosphatidylinositol 3-kinase activityGO:04355210.3KIT, PDGFRB, PDGFRA, FLT3
19positive regulation of phosphatidylinositol 3-kinase signalingGO:01406810.2KIT, PDGFRB, PDGFRA, FLT3
20fibroblast growth factor receptor signaling pathwayGO:00854310.2KITLG, KIT, PDGFRB, PDGFRA
21Fc-epsilon receptor signaling pathwayGO:03809510.2PDGFRA, PDGFRB, KIT, KITLG
22epidermal growth factor receptor signaling pathwayGO:00717310.2KITLG, KIT, PDGFRB, PDGFRA
23positive regulation of cell migrationGO:03033510.2KIT, PDGFRB, PDGFRA, CSF1R
24embryonic hemopoiesisGO:03516210.2KITLG, KIT
25cellular metabolic processGO:04423710.2SDHA, SDHC, SDHB
26neurotrophin TRK receptor signaling pathwayGO:04801110.1KITLG, KIT, PDGFRB, PDGFRA
27positive regulation of ERK1 and ERK2 cascadeGO:07037410.1CSF1R, PDGFRA, PDGFRB
28phosphatidylinositol-mediated signalingGO:04801510.1KITLG, KIT, PDGFRB, PDGFRA, CSF1R
29hemopoiesisGO:03009710.1CD34, KIT, CSF1R, FLT3
30regulation of cell shapeGO:00836010.1KIT, S100B, CSF1R
31cellular response to cytokine stimulusGO:07134510.0FLT3, CSF1R
32peptidyl-tyrosine phosphorylationGO:01810810.0FLT3, CSF1R, PDGFRA, PDGFRB, KIT
33protein autophosphorylationGO:04677710.0FLT3, CSF1R, PDGFRA, PDGFRB, KIT
34tissue homeostasisGO:00189410.0PDGFRB, CD34
35aerobic respirationGO:0090609.9SDHC, SDHB
36innate immune responseGO:0450879.9CSF1R, PDGFRA, PDGFRB, S100B, KIT, KITLG
37cell proliferationGO:0082839.8MKI67, CSF1R, S100B, KITLG, CD34
38positive regulation of cell proliferationGO:0082849.8FLT3, CSF1R, PDGFRA, PDGFRB, S100B, KIT

Molecular functions related to Gastrointestinal Stromal Tumor according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1succinate dehydrogenase (ubiquinone) activityGO:00817710.5SDHA, SDHB
2succinate dehydrogenase activityGO:00010410.4SDHA, SDHC
3vascular endothelial growth factor bindingGO:03808510.4PDGFRB, PDGFRA
4vascular endothelial growth factor-activated receptor activityGO:00502110.2FLT3, PDGFRA
5transmembrane receptor protein tyrosine kinase activityGO:00471410.2FLT3, PDGFRA, KIT
6platelet-derived growth factor bindingGO:04840710.2PDGFRB, PDGFRA
7S100 protein bindingGO:04454810.1S100B, S100A1
8phosphatidylinositol 3-kinase bindingGO:04354810.1PDGFRB, FLT3
9platelet-derived growth factor receptor bindingGO:00516110.1PDGFRA, PDGFRB
10cytokine bindingGO:0199559.8KIT, CSF1R
11protein homodimerization activityGO:0428039.6FLT3, CSF1R, PDGFRA, S100A1, S100B, KIT
12ATP bindingGO:0055249.4MKI67, FLT3, ACTC1, CSF1R, PDGFRA, PDGFRB
13protein bindingGO:0055158.1NF2, DES, MKI67, SDHB, SDHA, FLT3

Products for genes affiliated with Gastrointestinal Stromal Tumor

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Sources for Gastrointestinal Stromal Tumor

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet