MCID: GST019
MIFTS: 84

Gastrointestinal Stromal Tumor malady

Genetic diseases, Rare diseases, Gastrointestinal diseases, Cancer diseases categories

Summaries for Gastrointestinal Stromal Tumor

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OMIM:47 Gastrointestinal stromal tumors are mesenchymal tumors found in the gastrointestinal tract that originate from the... (606764) more...

MalaCards based summary: Gastrointestinal Stromal Tumor, also known as gastrointestinal stromal sarcoma, is related to neurofibromatosis and adenocarcinoma, and has symptoms including neoplasm of the stomach, sarcoma and nausea and vomiting. An important gene associated with Gastrointestinal Stromal Tumor is KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog), and among its related pathways are Osteoblast Signaling and Cardiac Progenitor Differentiation. The compounds monochloroacetic acid and pkc 412 have been mentioned in the context of this disorder. Affiliated tissues include small intestine, colon and smooth muscle, and related mouse phenotypes are limbs/digits/tail and hearing/vestibular/ear.

NIH Rare Diseases:43 Gastrointestinal stromal tumors are a type of soft tissue sarcoma (tumor) that usually begins in cells in the wall of the stomach, intestines, or rectum. these tumors may be noncancerous or cancerous. they can affect adults, adolescents, or children.  it is estimated that around 5,000 new cases of gastrointestinal stromal tumors are diagnosed in the united states each year. last updated: 4/27/2010

Genetics Home Reference:23 A gastrointestinal stromal tumor (GIST) is a type of tumor that occurs in the gastrointestinal tract, most commonly in the stomach or small intestine. The tumors are thought to grow from specialized cells found in the gastrointestinal tract called interstitial cells of Cajal (ICCs) or precursors to these cells. GISTs are usually found in adults between ages 40 and 70; rarely, children and young adults develop these tumors. The tumors can be cancerous (malignant) or noncancerous (benign).

Wikipedia:65 Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the... more...

Aliases & Classifications for Gastrointestinal Stromal Tumor

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Sources:
47OMIM, 10Disease Ontology, 11diseasecard, 43NIH Rare Diseases, 23Genetics Home Reference, 12DISEASES, 45Novoseek, 49Orphanet, 62UMLS, 22GeneTests, 24GTR, 57SNOMED-CT, 40NCIt, 35MeSH, 36MESH via Orphanet, 28ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Gastrointestinal Stromal Tumor, Aliases & Descriptions:

Name: Gastrointestinal Stromal Tumor 47 10 11 43 23 12 45 49
Gastrointestinal Stromal Sarcoma 43 23 49 62
Gastrointestinal Stromal Tumors 43 22 24 62
Gist 10 43 23 49
Stromal Tumor of Gastrointestinal Tract 10 62
 
Gastrointestinal Stromal Neoplasm 23 62
Gastrointestinal Stromal Tumor, Familial 47
Gastrointestinal Stromal Tumor, Somatic 47
Gant 10


Classifications:



Characteristics (Orphanet epidemiological data):

49
gastrointestinal stromal tumor:
Inheritance: Not applicable; Prevalence: 1-5/10000 (Europe); Age of onset: Adult


External Ids:

OMIM47 606764
Disease Ontology10 DOID:9253
NCIt40 C3868
MeSH35 D046152
Orphanet49 44890
MESH via Orphanet36 D046152
ICD10 via Orphanet28 C26.9
UMLS via Orphanet63 C0238198

Related Diseases for Gastrointestinal Stromal Tumor

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Diseases related to Gastrointestinal Stromal Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 276)
idRelated DiseaseScoreTop Affiliating Genes
1neurofibromatosis31.3NF2, PDGFRA, SDHC, SDHB
2adenocarcinoma31.2CD34, NF2, KITLG, PDGFRB, CSF1R, ITGA6
3leiomyoma31.1CD34, KIT, S100B, S100A1, PDGFRA, ACTC1
4leiomyosarcoma31.0CD34, KIT, S100B, S100A1, PDGFRB, PDGFRA
5fibromatosis31.0CD34, KIT, S100A1, PDGFRB, ACTC1, VIM
6leukemia30.8CD34, KITLG, KIT, PDGFRB, PDGFRA, CSF1R
7sarcoma30.8CD34, NF2, KITLG, KIT, S100B, S100A1
8carney triad30.8KIT, PDGFRA, SDHC, SDHB
9paraganglioma30.7KIT, S100B, S100A1, SDHA, SDHC, SDHB
10myeloid leukemia30.7CD34, KITLG, KIT, CSF1R, FLT3
11melanoma30.6CD34, NF2, KITLG, KIT, S100B, S100A1
12granular cell tumor30.5S100B, S100A1, VIM, DES
13adenoma30.5KITLG, S100A1, ITGA6, ACTC1, NES, MKI67
14hepatocellular carcinoma30.5CD34, PDGFRA, CSF1R, ITGA6, MKI67
15malignant peripheral nerve sheath tumor30.5CD34, NF2, KIT, S100B, S100A1, PDGFRA
16paraganglioma and gastric stromal sarcoma30.4SDHC, SDHB
17adenosarcoma30.3ACTC1, DES
18urticaria pigmentosa30.3KITLG, KIT
19perineurioma30.3CD34, S100B, VIM
20refractory anemia30.3KITLG, KIT, FLT3
21mastocytosis30.3KITLG, KIT, PDGFRB, PDGFRA
22angiosarcoma30.3CD34, PDGFRA, ACTC1, VIM
23endometriosis30.3PDGFRA, ITGA6, ACTC1
24hemangiopericytoma30.3CD34, S100B, S100A1, ACTC1, VIM, DES
25colorectal cancer30.3CD34, NF2, KITLG, PDGFRB, PDGFRA
26smooth muscle tumor30.2KIT, S100B, S100A1, ACTC1, VIM, MKI67
27myelodysplastic syndrome30.2CD34, KITLG, KIT, PDGFRB, PDGFRA, CSF1R
28glomus tumor30.2S100A1, ACTC1, VIM, SDHB, DES
29dermatofibrosarcoma protuberans30.2CD34, KIT, S100B, S100A1, PDGFRB, ACTC1
30breast cancer30.2NF2, S100A1, CSF1R, ITGA6, ACTC1, VIM
31chondroma30.2PDGFRA, SDHC, SDHB
32neurofibroma30.2CD34, NF2, KITLG, KIT, S100B, S100A1
33multiple endocrine neoplasia30.2NF2, SDHC, SDHB
34duodenitis10.8
35neurofibromatosis, type 110.7
36pancreatitis10.7
37esophagitis10.7
38intussusception10.6
39hepatitis10.5
40hypoglycemia10.5
41prostatitis10.5
42meckel's diverticulum10.5
43gastric adenocarcinoma10.5
44peritonitis10.5
45endotheliitis10.5
46pheochromocytoma10.4
47renal cell carcinoma10.4
48somatostatinoma10.4
49neuroendocrine tumor10.4
50bacteremia10.3

Graphical network of the top 20 diseases related to Gastrointestinal Stromal Tumor:



Diseases related to gastrointestinal stromal tumor

Symptoms for Gastrointestinal Stromal Tumor

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Symptoms by clinical synopsis from OMIM:

606764

Clinical features from OMIM:

606764

Symptoms:

 49 (show all 18)
  • estomach/gastric neoplasm/tumor/carcinoma/cancer
  • sarcoma
  • feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • constipation
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • intestinal obstruction/ileus
  • intestinal perforation
  • asthenia/fatigue/weakness
  • cutaneous rash
  • irregular/in bands/reticular skin hyperpigmentation
  • hepatitis/icterus/cholestasis
  • anaemia
  • digestive neoplasm/tumor/carcinoma/cancer
  • esophageal neoplasm/tumor/carcinoma/cancer
  • small bowel neoplasm/tumor/carcinoma/cancer
  • colon neoplasm/tumor/carcinoma/cancer
  • rectum/rectal neoplasm/tumor/carcinoma/cancer

HPO human phenotypes related to Gastrointestinal Stromal Tumor:

(show all 25)
id Description Frequency HPO Source Accession
1 neoplasm of the stomach hallmark (90%) HP:0006753
2 sarcoma hallmark (90%) HP:0100242
3 nausea and vomiting typical (50%) HP:0002017
4 constipation typical (50%) HP:0002019
5 gastrointestinal hemorrhage typical (50%) HP:0002239
6 intestinal obstruction typical (50%) HP:0005214
7 feeding difficulties in infancy typical (50%) HP:0008872
8 skin rash occasional (7.5%) HP:0000988
9 abnormality of the liver occasional (7.5%) HP:0001392
10 anemia occasional (7.5%) HP:0001903
11 irregular hyperpigmentation occasional (7.5%) HP:0007400
12 neoplasm of the colon occasional (7.5%) HP:0100273
13 neoplasm of the rectum occasional (7.5%) HP:0100743
14 esophageal neoplasm occasional (7.5%) HP:0100751
15 neoplasm of the small intestine occasional (7.5%) HP:0100833
16 autosomal dominant inheritance HP:0000006
17 hyperpigmentation of the skin HP:0000953
18 urticaria HP:0001025
19 neurofibromas HP:0001067
20 large hands HP:0001176
21 dysphagia HP:0002015
22 constipation HP:0002019
23 sporadic HP:0003745
24 intestinal obstruction HP:0005214
25 gastrointestinal stroma tumor HP:0100723

Drugs & Therapeutics for Gastrointestinal Stromal Tumor

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Drug clinical trials:

Search ClinicalTrials for Gastrointestinal Stromal Tumor

Search NIH Clinical Center for Gastrointestinal Stromal Tumor

Genetic Tests for Gastrointestinal Stromal Tumor

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Genetic tests related to Gastrointestinal Stromal Tumor:

id Genetic test Affiliating Genes
1 Gastrointestinal Stromal Tumor22 PDGFRA
2 Gastrointestinal Stromal Tumors24

Anatomical Context for Gastrointestinal Stromal Tumor

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MalaCards organs/tissues related to Gastrointestinal Stromal Tumor:

33
Small intestine, Colon, Smooth muscle, Liver, Skin, Bone, Pancreas, Lymph node, Prostate, Endothelial, Testes, Myeloid, Appendix, Brain, Thyroid, Bone marrow, Spleen, Heart, Skeletal muscle, Breast, Ovary, Uterus, T cells, B cells, Tongue, Neutrophil

Animal Models for Gastrointestinal Stromal Tumor or affiliated genes

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MGI Mouse Phenotypes related to Gastrointestinal Stromal Tumor:

37 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.7KITLG, KIT, PDGFRA, CSF1R, ITGA6
2MP:00053779.6ITGA6, CSF1R, KIT, KITLG, NF2
3MP:00053829.5ITGA6, CSF1R, PDGFRA, PDGFRB, KIT, KITLG
4MP:00020069.5FLT3, ITGA6, PDGFRA, KIT, KITLG, NF2
5MP:00053919.5SDHC, VIM, ITGA6, PDGFRB, KIT, KITLG
6MP:00053699.4DES, VIM, ETV1, ACTC1, PDGFRA, PDGFRB
7MP:00053809.4VIM, NES, ITGA6, PDGFRA, PDGFRB, KIT
8MP:00053799.4ITGA6, CSF1R, PDGFRA, PDGFRB, KIT, KITLG
9MP:00053859.2DES, VIM, ACTC1, ITGA6, PDGFRA, PDGFRB
10MP:00107719.2ITGA6, CSF1R, PDGFRA, PDGFRB, S100B, KIT
11MP:00028739.2ETV1, ACTC1, PDGFRA, PDGFRB, S100A1, S100B
12MP:00036319.1VIM, NES, ETV1, ITGA6, PDGFRA, PDGFRB
13MP:00053979.0FLT3, VIM, ITGA6, CSF1R, PDGFRA, PDGFRB
14MP:00053899.0VIM, CSF1R, PDGFRA, PDGFRB, KIT, KITLG
15MP:00053869.0DES, VIM, NES, ETV1, CSF1R, PDGFRA
16MP:00053878.9CSF1R, ITGA6, VIM, FLT3, PDGFRA, PDGFRB
17MP:00053768.8DES, FLT3, VIM, ACTC1, CSF1R, PDGFRA
18MP:00053788.7ACTC1, ETV1, NES, VIM, FLT3, ITGA6
19MP:00053848.6ACTC1, ETV1, NES, VIM, FLT3, ITGA6
20MP:00107688.4NF2, DES, SDHC, FLT3, VIM, NES

Publications for Gastrointestinal Stromal Tumor

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Articles related to Gastrointestinal Stromal Tumor:

(show top 50)    (show all 1151)
idTitleAuthorsYear
1
Inhibition of KIT-Glycosylation by 2-Deoxyglucose Abrogates KIT-Signaling and Combination with ABT-263 Synergistically Induces Apoptosis in Gastrointestinal Stromal Tumor. (25781619)
2015
2
Gastric Schwannoma mimicking malignant gastrointestinal stromal tumor and misdiagnosed by (18)F-FDG PET/CT. (25840576)
2015
3
Chromosomal aberrations in primary PDGFRA-mutated gastrointestinal stromal tumors. (24157063)
2014
4
Angiomatous leiomyoma of the urachus: A rare entity masquerading as extraluminal gastrointestinal stromal tumor. (24049386)
2013
5
Single-incision laparoscopic and endoscopic cooperative surgery for gastrointestinal stromal tumor arising from the duodenum. (24308591)
2013
6
Gastrointestinal stromal tumor of small intestine and synchronous bilateral papillary renal cell carcinoma. (24195178)
2013
7
Gastrointestinal stromal tumor: an unusual cause of gastrointestinal bleeding. (23633157)
2013
8
Gastrointestinal stromal tumor with dedifferentiation to undifferentiated pleomorphic sarcoma. (24200161)
2013
9
Dedifferentiation in gastrointestinal stromal tumor to an anaplastic KIT-negative phenotype: a diagnostic pitfall: morphologic and molecular characterization of 8 cases occurring either de novo or after imatinib therapy. (23348204)
2013
10
Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147) is associated with low survival in patients with gastrointestinal stromal tumors (GISTs). (22281667)
2012
11
Surgical treatment of a giant mesenteric fibromatosis mimicking a gastrointestinal stromal tumor: a case report and current treatment aspects. (23175930)
2012
12
GLP-2 receptors in human disease: high expression in gastrointestinal stromal tumors and Crohn's disease. (22951144)
2012
13
A Case of KIT-Negative Extra-Gastrointestinal Stromal Tumor of the Lesser Omentum. (22855655)
2012
14
Multifocal gastric gastrointestinal stromal tumors (GISTs) with lymph node metastases in children and young adults: a comparative clinical and histomorphological study of three cases including a new case of Carney triad. (21663639)
2011
15
Synchronous double tumor of breast cancer and gastrointestinal stromal tumor in a patient with neurofibromatosis type 1: report of a case. (22199319)
2011
16
Frequency, phenotype, and genotype of minute gastrointestinal stromal tumors in the stomach: an autopsy study. (21658742)
2011
17
Gastrointestinal stromal tumor presenting as dyspareunia. (22234771)
2011
18
CT features, mimics and atypical presentations of gastrointestinal stromal tumor (GIST). (22013291)
2011
19
Recurring gastrointestinal stromal tumor with splenic metastasis. (22319733)
2011
20
Unusual metastases of gastrointestinal stromal tumor and genotypic correlates: Case report and review of the literature. (22811827)
2011
21
Comparison of RECIST and Choi criteria for computed tomographic response evaluation in patients with advanced gastrointestinal stromal tumor treated with sunitinib. (21289369)
2011
22
First report of connexin 43-positive gastrointestinal stromal tumor (GIST). (21462830)
2010
23
Is laparoscopic resection the appropriate management of a jejunal gastrointestinal stromal tumor (GIST)? Report of a case. (20975491)
2010
24
Detection of treatment-induced changes in signaling pathways in gastrointestinal stromal tumors using transcriptomic data. (19903850)
2009
25
Kinase mutations and efficacy of imatinib in Korean patients with advanced gastrointestinal stromal tumors. (19411681)
2009
26
Aberrations of chromosome 13q in gastrointestinal stromal tumors: analysis of 91 cases by fluorescence in situ hybridization (FISH). (19430298)
2009
27
Expression of CD117, CD34, SMA, S-100 protein, Vim and desmin in patients with gastrointestinal stromal tumors]. (18359707)
2008
28
PDGFRalpha gene mutation and protein expression in gastrointestinal stromal tumors. (18547963)
2008
29
Site-dependent differential KIT and PDGFRA expression in gastric and intestinal gastrointestinal stromal tumors. (17673922)
2007
30
Imatinib in gastrointestinal stromal tumor treatment--results from University Hospital Centre Zagreb]. (16910417)
2006
31
Gastrointestinal stromal tumors express the orexigen ghrelin. (16954444)
2006
32
Malignant gastrointestinal stromal tumor of the ampulla of Vater presenting with obstructive jaundice. (16855323)
2006
33
Interobserver variability in histologic recognition, interpretation of KIT immunostaining, and determining MIB-1 labeling indices in gastrointestinal stromal tumors and other spindle cell tumors of the gastrointestinal tract. (16540730)
2006
34
Polyclonal evolution of multiple secondary KIT mutations in gastrointestinal stromal tumors under treatment with imatinib mesylate. (16551858)
2006
35
A long-term survival case with multiple liver metastases from duodenal gastrointestinal stromal tumor that was drastically reduced by the treatment with imatinib]. (16315926)
2005
36
Hypoxia-inducible factor-1alpha is associated with risk of aggressive behavior and tumor angiogenesis in gastrointestinal stromal tumor. (15845570)
2005
37
Serum KIT and KIT ligand levels in patients with gastrointestinal stromal tumors treated with imatinib. (15070666)
2004
38
Current clinical management of gastrointestinal stromal tumors. (15270663)
2004
39
Malignant gastrointestinal stromal tumor originating in the lesser omentum, complicated by rapidly progressive glomerulonephritis and gastric carcinoma. (15005250)
2004
40
A new mutation in the KIT ATP pocket causes acquired resistance to imatinib in a gastrointestinal stromal tumor patient. (15236194)
2004
41
Gastrointestinal stromal tumors in a mouse model by targeted mutation of the Kit receptor tyrosine kinase. (12754375)
2003
42
PDGFRA activating mutations in gastrointestinal stromal tumors. (12522257)
2003
43
Secondary amyloidosis and gastrointestinal stromal tumors. A case report and discussion of pathogenesis. (12683877)
2003
44
Prognostic predictors of gastrointestinal stromal tumors: a multi-institutional analysis of 102 patients with definition of a prognostic index. (12875864)
2003
45
Hypoxia-inducible factor-1alpha expression and angiogenesis in gastrointestinal stromal tumor of the stomach. (12792726)
2003
46
Approval summary: imatinib mesylate in the treatment of metastatic and/or unresectable malignant gastrointestinal stromal tumors. (12374669)
2002
47
Specific mutation in exon 11 of c-kit proto-oncogene in a malignant gastrointestinal stromal tumor of the rectum. (11063223)
2000
48
C-kit gene abnormalities in gastrointestinal stromal tumors (tumors of interstitial cells of Cajal. (10665649)
1999
49
Mutations of c-kit JM domain are found in a minority of human gastrointestinal stromal tumors. (10086344)
1999
50
The gastric hypercellular microleiomyoma as a precursor lesion for clinical gastrointestinal stromal tumors. (9416690)
1997

Variations for Gastrointestinal Stromal Tumor

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UniProtKB/Swiss-Prot genetic disease variations for Gastrointestinal Stromal Tumor:

64
id Symbol AA change Variation ID SNP ID
1KITp.Lys550IleVAR_033123rs28933968
2KITp.Val559AlaVAR_033126
3KITp.Val559AspVAR_033127
4PDGFRAp.Tyr849CysVAR_066474

Clinvar genetic disease variations for Gastrointestinal Stromal Tumor:

7 (show all 14)
id Gene Variation Type Significance SNP ID Assembly Location
1SDHBNM_003000.2(SDHB): c.725G> A (p.Arg242His)single nucleotide variantPathogenicrs74315368GRCh37Chr 1, 17349143: 17349143
2PDGFRANM_006206.4(PDGFRA): c.2525A> T (p.Asp842Val)single nucleotide variantPathogenicrs121908585GRCh37Chr 4, 55152093: 55152093
3PDGFRAPDGFRA, 4-CODON DEL, 842DIMHdeletionPathogenic
4PDGFRAPDGFRA, 4-CODON DEL, 845HDSNdeletionPathogenic
5PDGFRANM_006206.4(PDGFRA): c.1682T> A (p.Val561Asp)single nucleotide variantPathogenicrs121908586GRCh37Chr 4, 55141036: 55141036
6PDGFRAPDGFRA, 2-CODON INS, 561ERinsertionPathogenic
7PDGFRAPDGFRA, 5-CODON DEL, 560RVIESdeletionPathogenic
8PDGFRAPDGFRA, 6-CODON DEL, 566SPDGHEdeletionPathogenic
9KITKIT, 6-BP DELdeletionPathogenic
10KITKIT, 15-BP DELdeletionPathogenic
11KITKIT, 15-BP DEL/LYS550ILEdeletionPathogenic
12KITNM_000222.2(KIT): c.1676T> A (p.Val559Asp)single nucleotide variantPathogenicrs121913517GRCh37Chr 4, 55593610: 55593610
13KITKIT, 27-BP DELdeletionPathogenic
14SDHCNM_003001.3(SDHC): c.405+1G> Asingle nucleotide variantPathogenicGRCh37Chr 1, 161326631: 161326631

Expression for genes affiliated with Gastrointestinal Stromal Tumor

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Search GEO for disease gene expression data for Gastrointestinal Stromal Tumor.

Pathways for genes affiliated with Gastrointestinal Stromal Tumor

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Pathways related to Gastrointestinal Stromal Tumor according to GeneCards/GeneDecks:

(show all 35)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2PDGFRB, PDGFRA
210.1PDGFRA, ACTC1, KIT
3
Show member pathways
TCA cycle38
pyruvate decarboxylation to acetyl CoA38
NAD phosphorylation and dephosphorylation38
TCA Cycle38
conversion of glucose to acetyl CoA and entry into the TCA cycle38
10.1SDHC, SDHA, SDHB
4
Show member pathways
L-serine degradation38
pentose phosphate pathway (oxidative branch)38
formaldehyde oxidation II (glutathione-dependent)38
10.1SDHA, SDHC, SDHB
510.0ITGA6, PDGFRB, PDGFRA
6
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy38
10.0ACTC1, DES, ITGA6
710.0PDGFRB, NF2, PDGFRA
8
Show member pathways
10.0ACTC1, VIM, DES
9
Show member pathways
Cytoskeleton remodeling Neurofilaments60
10.0VIM, DES, NES
10
Show member pathways
9.9KITLG, PDGFRB, PDGFRA, KIT
11
Show member pathways
9.9PDGFRB, KITLG, KIT, PDGFRA
12
Show member pathways
Development EDNRB signaling60
Development ACM2 and ACM4 activation of ERK60
Cell adhesion Integrin inside out signaling60
Development G Proteins mediated regulation MARK ERK signaling60
Signal transduction IP3 signaling60
Development Angiotensin signaling via PYK260
Development EPO induced MAPK pathway60
9.9KITLG, KIT, PDGFRB, PDGFRA
13
Show member pathways
9.8KIT, PDGFRB, PDGFRA, FLT3
149.8ACTC1, VIM, DES, NF2
15
Show member pathways
9.7KITLG, KIT, PDGFRB, ITGA6, PDGFRA
16
Show member pathways
9.7KIT, PDGFRB, KITLG, PDGFRA, ITGA6
179.7KITLG, KIT, CD34, CSF1R
18
Show member pathways
9.7KIT, S100B, PDGFRB, KITLG, PDGFRA
19
Show member pathways
9.7PDGFRB, KIT, KITLG, PDGFRA, CSF1R
20
Show member pathways
9.7KITLG, KIT, PDGFRB, CSF1R, PDGFRA
21
Show member pathways
9.7KITLG, KIT, PDGFRB, PDGFRA, CSF1R
22
Show member pathways
9.6KIT, PDGFRB, CD34, KITLG, PDGFRA
239.5PDGFRA, KITLG, KIT, ITGA6, CSF1R, PDGFRB
24
Show member pathways
9.5PDGFRA, PDGFRB, KIT, KITLG, CSF1R, FLT3
25
Show member pathways
9.5FLT3, CSF1R, PDGFRA, PDGFRB, KIT, KITLG
269.5PDGFRA, PDGFRB, KIT, CSF1R, KITLG, FLT3
27
Show member pathways
9.5KIT, KITLG, PDGFRB, CSF1R, FLT3, PDGFRA
28
Show member pathways
9.5KIT, PDGFRB, CSF1R, ITGA6, FLT3, PDGFRA
299.3CD34, ITGA6, CSF1R, KIT, KITLG, FLT3
30
Show member pathways
9.3PDGFRB, FLT3, ITGA6, PDGFRA, KITLG, KIT
31
Show member pathways
9.3ITGA6, CSF1R, PDGFRA, PDGFRB, KIT, KITLG
329.3KIT, PDGFRA, PDGFRB, KITLG, FLT3, CSF1R
33
Show member pathways
9.3KITLG, FLT3, PDGFRA, CSF1R, PDGFRB, KIT
34
Show member pathways
9.1PDGFRB, KIT, KITLG, CSF1R, ETV1, ITGA6
35
Show member pathways
8.9PDGFRB, ITGA6, VIM, FLT3, DES, KIT

Compounds for genes affiliated with Gastrointestinal Stromal Tumor

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Compounds related to Gastrointestinal Stromal Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 132)
idCompoundScoreTop Affiliating Genes
1monochloroacetic acid4510.3VIM, KITLG, KIT
2pkc 4124510.2FLT3, KIT, PDGFRB, PDGFRA
3orcein4510.2S100B, ACTC1, VIM, DES
4s 1004510.2VIM, DES, ACTC1, S100B
5Fumaric acid2610.2SDHB, SDHC, SDHA
6su54164510.2FLT3, KITLG, KIT, PDGFRB
7ag-12964510.1PDGFRA, KIT, FLT3, PDGFRB, KITLG
8sunitinib45 51 1312.0PDGFRB, CSF1R, KIT, FLT3, PDGFRA
9toluidine4510.0KITLG, KIT, VIM, DES, S100A1
10mucicarmine4510.0ACTC1, S100A1, S100B, DES, VIM
11reticulin4510.0VIM, ACTC1, CD34, S100B, DES
12b 7234510.0ACTC1, DES, VIM, S100B, S100A1
13methylcellulose459.9FLT3, CD34, KITLG, KIT
14cytarabine45 51 1311.8CSF1R, FLT3, KITLG, VIM, KIT
15formaldehyde45 2610.8ACTC1, DES, VIM, KIT, MKI67, S100B
16agarose459.8ITGA6, S100B, KIT, KITLG, FLT3
17tgf beta1459.8PDGFRB, MKI67, FLT3, VIM, PDGFRA, KITLG
18biotin45 26 1311.8VIM, KITLG, S100A1, ACTC1, MKI67, DES
19phosphotyrosine459.7KIT, FLT3, ITGA6, CSF1R, PDGFRA, PDGFRB
20methionine459.7PDGFRB, VIM, S100B, DES, CSF1R, KIT
21paclitaxel45 51 1311.7VIM, MKI67, PDGFRB, KIT, KITLG, S100B
22rapamycin459.7FLT3, VIM, KITLG, PDGFRB, KIT, PDGFRA
23bromodeoxyuridine459.7NES, PDGFRB, S100B, KITLG, VIM, MKI67
24methotrexate51 45 1311.6VIM, MKI67, KIT, ITGA6, KITLG
25agar459.6CSF1R, VIM, CD34, NF2, PDGFRB, KITLG
26dmso459.6CSF1R, VIM, SDHB, NES, KITLG
27doxorubicin45 51 1311.6MKI67, FLT3, KITLG, DES, VIM, KIT
282-methoxyethanol459.6ACTC1, VIM, S100A1
29glycogen45 2610.5SDHB, MKI67, VIM, DES, ACTC1, S100A1
30lactate459.5VIM, DES, MKI67, SDHB, KITLG, KIT
31steroid459.5KIT, KITLG, DES, S100B, CSF1R, ACTC1
32thymidine45 2610.4FLT3, PDGFRA, DES, KIT, KITLG, CD34
33imatinib45 51 1311.4KITLG, KIT, S100B, PDGFRB, PDGFRA, CSF1R
34hematoxylin459.4DES, S100B, KIT, CD34, MKI67, VIM
35iron45 2610.4S100B, KITLG, S100A1, ACTC1, VIM, SDHA
36glucose459.4KIT, S100B, PDGFRB, ACTC1, NES, SDHB
37threonine459.3MKI67, FLT3, CSF1R, PDGFRB, S100B, KIT
38atp45 3010.3SDHB, KIT, S100B, PDGFRB, PDGFRA, CSF1R
39oligonucleotide459.3VIM, ITGA6, CSF1R, PDGFRA, PDGFRB, KIT
40oxygen45 2610.3S100B, DES, KITLG, MKI67, SDHB, SDHC
41cysteine459.2KIT, NF2, VIM, S100B, S100A1, PDGFRB
42testosterone45 61 26 1312.2SDHB, S100B, KIT, KITLG, ACTC1, ETV1
43serine459.0PDGFRB, CSF1R, NF2, KITLG, KIT, S100B
44calcium45 51 26 1311.7PDGFRA, PDGFRB, S100A1, S100B, KIT, KITLG
45estrogen458.6NES, VIM, MKI67, DES, ACTC1, CSF1R
46progesterone45 30 61 26 1312.5VIM, MKI67, CD34, NF2, KIT, S100B
47paraffin458.4VIM, MKI67, NES, ACTC1, DES, CD34
48vegf458.2SDHC, FLT3, VIM, NES, ACTC1, ITGA6
49retinoic acid45 269.1VIM, FLT3, SDHC, MKI67, DES, NES
50tyrosine457.9CSF1R, ITGA6, ACTC1, ETV1, PDGFRA, PDGFRB

GO Terms for genes affiliated with Gastrointestinal Stromal Tumor

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Cellular components related to Gastrointestinal Stromal Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intrinsic component of plasma membraneGO:003122610.2PDGFRB, PDGFRA
2mitochondrial respiratory chain complex IIGO:000574910.2SDHB, SDHC, SDHA
3external side of plasma membraneGO:00098979.9CD34, KIT, PDGFRA, ITGA6
4intermediate filamentGO:00058829.7DES, VIM, NES
5plasma membraneGO:00058868.8VIM, ITGA6, CSF1R, PDGFRA, PDGFRB, KIT
6cytoplasmGO:00057378.7NES, CD34, NF2, KITLG, S100B, PDGFRB

Biological processes related to Gastrointestinal Stromal Tumor according to GeneCards/GeneDecks:

(show all 38)
idNameGO IDScoreTop Affiliating Genes
1metanephric glomerular capillary formationGO:007227710.5PDGFRB, PDGFRA
2positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathwayGO:003809110.5PDGFRA, PDGFRB
3retina vasculature development in camera-type eyeGO:006129810.5PDGFRB, PDGFRA
4positive regulation of phospholipase C activityGO:001086310.5KIT, PDGFRA, PDGFRB
5ectopic germ cell programmed cell deathGO:003523410.5KITLG, KIT
6myeloid progenitor cell differentiationGO:000231810.5FLT3, KIT
7tricarboxylic acid cycleGO:000609910.5SDHB, SDHA, SDHC
8succinate metabolic processGO:000610510.4SDHA, SDHB
9cardiac myofibril assemblyGO:005500310.4PDGFRB, ACTC1, PDGFRA
10cell chemotaxisGO:006032610.4PDGFRB, PDGFRA, KIT
11muscle filament slidingGO:003004910.4DES, VIM, ACTC1
12regulation of actin cytoskeleton reorganizationGO:0200024910.4CSF1R, PDGFRA
13stem cell proliferationGO:007208910.3NES, CD34
14odontogenesis of dentin-containing toothGO:004247510.3PDGFRA, ITGA6, NF2
15positive regulation of MAP kinase activityGO:004340610.3KITLG, PDGFRB, FLT3
16respiratory electron transport chainGO:002290410.3SDHC, SDHB, SDHA
17positive regulation of phosphatidylinositol 3-kinase activityGO:004355210.3PDGFRA, FLT3, KIT, PDGFRB
18phosphatidylinositol metabolic processGO:004648810.3PDGFRB, CSF1R
19positive regulation of phosphatidylinositol 3-kinase signalingGO:001406810.3PDGFRB, PDGFRA, FLT3, KIT
20fibroblast growth factor receptor signaling pathwayGO:000854310.2KITLG, PDGFRA, KIT, PDGFRB
21Fc-epsilon receptor signaling pathwayGO:003809510.2KIT, KITLG, PDGFRB, PDGFRA
22epidermal growth factor receptor signaling pathwayGO:000717310.2PDGFRB, KIT, PDGFRA, KITLG
23positive regulation of cell migrationGO:003033510.2PDGFRB, KIT, PDGFRA, CSF1R
24aerobic respirationGO:000906010.2SDHB, SDHC
25neurotrophin TRK receptor signaling pathwayGO:004801110.2PDGFRA, PDGFRB, KIT, KITLG
26cellular metabolic processGO:004423710.1SDHB, SDHC, SDHA
27positive regulation of ERK1 and ERK2 cascadeGO:007037410.1CSF1R, PDGFRA, PDGFRB
28phosphatidylinositol-mediated signalingGO:004801510.1CSF1R, PDGFRA, KITLG, KIT, PDGFRB
29hemopoiesisGO:003009710.1CSF1R, KIT, CD34, FLT3
30regulation of cell shapeGO:000836010.1CSF1R, S100B, KIT
31tissue homeostasisGO:000189410.1PDGFRB, CD34
32peptidyl-tyrosine phosphorylationGO:001810810.0CSF1R, KIT, PDGFRB, PDGFRA, FLT3
33protein autophosphorylationGO:004677710.0PDGFRA, CSF1R, PDGFRB, KIT, FLT3
34cellular response to cytokine stimulusGO:00713459.9CSF1R, FLT3
35embryonic hemopoiesisGO:00351629.9KIT, KITLG
36innate immune responseGO:00450879.9CSF1R, PDGFRA, S100B, PDGFRB, KIT, KITLG
37positive regulation of cell proliferationGO:00082849.8KIT, S100B, PDGFRB, PDGFRA, CSF1R, FLT3
38cell proliferationGO:00082839.8MKI67, CSF1R, S100B, KITLG, CD34

Molecular functions related to Gastrointestinal Stromal Tumor according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1succinate dehydrogenase (ubiquinone) activityGO:000817710.4SDHB, SDHA
2vascular endothelial growth factor bindingGO:003808510.4PDGFRB, PDGFRA
3succinate dehydrogenase activityGO:000010410.4SDHC, SDHA
4vascular endothelial growth factor-activated receptor activityGO:000502110.3FLT3, PDGFRA
5platelet-derived growth factor bindingGO:004840710.2PDGFRB, PDGFRA
6transmembrane receptor protein tyrosine kinase activityGO:000471410.2FLT3, PDGFRA, KIT
7phosphatidylinositol 3-kinase bindingGO:004354810.1PDGFRB, FLT3
8platelet-derived growth factor receptor bindingGO:000516110.1PDGFRA, PDGFRB
9S100 protein bindingGO:004454810.1S100B, S100A1
10cytokine bindingGO:00199559.8CSF1R, KIT
11protein homodimerization activityGO:00428039.6FLT3, CSF1R, PDGFRA, S100A1, S100B, KIT
12ATP bindingGO:00055249.4KIT, CSF1R, PDGFRB, PDGFRA, MKI67, FLT3
13protein bindingGO:00055158.1S100B, PDGFRB, PDGFRA, ITGA6, ETV1, VIM

Products for genes affiliated with Gastrointestinal Stromal Tumor

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Sources for Gastrointestinal Stromal Tumor

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet