Gastrointestinal Stromal Tumor, Somatic malady

MalaCards: Gastrointestinal Stromal Tumor, Somatic, also known as gastrointestinal stromal tumors, is related to gastrointestinal stromal tumor and leiomyoma. An important gene associated with Gastrointestinal Stromal Tumor, Somatic is PDGFRA (platelet-derived growth factor receptor, alpha polypeptide), and among its related pathways are Innate Immune System and Tyrosine Kinases / Adaptors. The compounds pkc 412 and ag-1296 have been mentioned in the context of this disorder. Related mouse phenotype pigmentation.

OMIM: 606764

gastrointestinal stromal tumor, somatic 33 gastrointestinal stromal tumors 43

Diseases related to gastrointestinal stromal tumor, somatic by text searches and GeneDecks gene sharing:

(show top 50)    (show all 86)

id	Related Disease	Score	Top Affiliating Genes
1	gastrointestinal stromal tumor	40.6	KIT, PDGFRA
2	leiomyoma	32.5	KIT, PDGFRA
3	leiomyosarcoma	32.3	KIT, PDGFRA
4	neurofibromatosis	31.7	KIT, PDGFRA
5	carney triad	30.3	PDGFRA, KIT
6	perineurioma	28.9	KIT, PDGFRA
7	neurofibroma	28.9	KIT, PDGFRA
8	mastocytosis	28.9	PDGFRA, KIT
9	fibromatosis	28.9	KIT, PDGFRA
10	fibrosarcoma of bone	12.6	KIT, PDGFRA
11	piebaldism	12.6	PDGFRA, KIT
12	sarcomatoid renal cell carcinoma	12.6	KIT, PDGFRA
13	chondroma	12.6	PDGFRA, KIT
14	chronic myelomonocytic leukemia	12.6	KIT, PDGFRA
15	gliosarcoma	12.6	KIT, PDGFRA
16	uterine sarcoma	12.6	KIT, PDGFRA
17	desmoid tumor	12.6	PDGFRA, KIT
18	ocular melanoma	12.6	PDGFRA, KIT
19	sm-ahnmd	12.6	KIT, PDGFRA
20	hypereosinophilic syndrome	12.6	KIT, PDGFRA
21	adenosquamous carcinoma	12.6	KIT, PDGFRA
22	dermatofibrosarcoma protuberans	12.6	PDGFRA, KIT
23	endometrial stromal sarcoma	12.6	PDGFRA, KIT
24	dermatofibrosarcoma	12.6	PDGFRA, KIT
25	neurilemmoma	12.6	KIT, PDGFRA
26	malignant peripheral nerve sheath tumor	12.5	PDGFRA, KIT
27	angiosarcoma	12.5	KIT, PDGFRA
28	peripheral primitive neuroectodermal tumor	12.5	KIT, PDGFRA
29	abrikosov's tumor	12.5	PDGFRA, KIT
30	nephroblastoma	12.5	KIT, PDGFRA
31	merkel cell carcinoma	12.5	KIT, PDGFRA
32	cblc	12.5	KIT, PDGFRA
33	polycythemia vera	12.5	PDGFRA, KIT
34	myelofibrosis	12.5	KIT, PDGFRA
35	cerebral primitive neuroectodermal tumor	12.5	KIT, PDGFRA
36	neuroendocrine carcinoma	12.5	KIT, PDGFRA
37	pediatric cns embryonal cell carcinoma	12.5	PDGFRA, KIT
38	myelodysplastic syndrome	12.5	PDGFRA, KIT
39	polycythemia	12.5	KIT, PDGFRA
40	neuroectodermal tumors	12.5	KIT, PDGFRA
41	small cell carcinoma	12.5	PDGFRA, KIT
42	myeloproliferative disorder	12.5	KIT, PDGFRA
43	seminoma	12.4	KIT, PDGFRA
44	testicular germ cell tumor	12.4	KIT, PDGFRA
45	adenoid cystic carcinoma	12.4	PDGFRA, KIT
46	thymoma	12.4	KIT, PDGFRA
47	vitiligo	12.4	PDGFRA, KIT
48	chronic myeloid leukemia	12.4	PDGFRA, KIT
49	soft tissue sarcoma	12.3	KIT, PDGFRA
50	adenoiditis	12.3	PDGFRA, KIT

Clinical features from OMIM: 606764

Approved drugs:

Drug clinical trials:

MGI Mouse Phenotypes related to gastrointestinal stromal tumor, somatic:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	pigmentation phenotype	MP:0001186	9.1	KIT, PDGFRA

Genes related to gastrointestinal stromal tumor, somatic according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	11.0
2	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	11.0

Pathways related to gastrointestinal stromal tumor, somatic according to GeneDecks:

(show all 39)

id	Pathway	Score	Top Affiliating Genes
1	Innate Immune System38	9.6	PDGFRA, KIT
2	Tyrosine Kinases / Adaptors3	9.6	KIT, PDGFRA
3	Actin Nucleation and Branching36	9.5	PDGFRA, KIT
4	Apoptotic Pathways in Synovial Fibroblasts36	9.5	KIT, PDGFRA
5	P2Y Receptor Signaling36	9.5	KIT, PDGFRA
6	p53 Mediated Apoptosis36	9.5	PDGFRA, KIT
7	Telomerase Components in Cell Signaling36	9.5	PDGFRA, KIT
8	Actin Nucleation by ARP-WASP Complex36	9.5	PDGFRA, KIT
9	CDC42 Pathway36	9.5	PDGFRA, KIT
10	Mitochondrial Apoptosis36	9.5	PDGFRA, KIT
11	DHA Signaling36	9.5	PDGFRA, KIT
12	ERK5 Signaling36	9.5	KIT, PDGFRA
13	Cellular Apoptosis Pathway36	9.5	PDGFRA, KIT
14	Endocytosis20	9.5	KIT, PDGFRA
15	PPAR Pathway36	9.5	PDGFRA, KIT
16	eIF2 Pathway36	9.5	PDGFRA, KIT
17	Nanog in Mammalian ESC Pluripotency36	9.5	KIT, PDGFRA
18	Nuclear Receptor Activation by Vitamin-A36	9.5	KIT, PDGFRA
19	Actin-Based Motility by Rho Family GTPases36	9.5	PDGFRA, KIT
20	p70S6K Signaling36	9.5	KIT, PDGFRA
21	Activation of PKC through GPCR36	9.5	PDGFRA, KIT
22	Paxillin Interactions36	9.5	PDGFRA, KIT
23	Endothelin-1 Signaling Pathway36	9.4	PDGFRA, KIT
24	Renin-Angiotensin Pathway36	9.4	KIT, PDGFRA
25	14-3-3 Induced Intracellular Signaling36	9.4	KIT, PDGFRA
26	Ras Pathway36	9.4	PDGFRA, KIT
27	Pancreatic Adenocarcinoma36	9.4	PDGFRA, KIT
28	Cytokine-cytokine receptor interaction20	9.4	PDGFRA, KIT
29	eNOS Signaling36	9.4	KIT, PDGFRA
30	CREB Pathway36	9.4	PDGFRA, KIT
31	NFAT in Immune Response36	9.3	PDGFRA, KIT
32	PTEN Pathway36	9.3	KIT, PDGFRA
33	Estrogen Pathway36	9.3	KIT, PDGFRA
34	GPCR Pathway36	9.2	KIT, PDGFRA
35	GSK3 Signaling36	9.2	KIT, PDGFRA
36	PAK Pathway36	9.1	PDGFRA, KIT
37	JAK-STAT Pathway36	9.1	PDGFRA, KIT
38	Pathways in cancer20	9.0	KIT, PDGFRA
39	JNK Pathway36	8.8	PDGFRA, KIT

Compounds related to gastrointestinal stromal tumor, somatic according to GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	pkc 41232	9.3	PDGFRA, KIT
2	ag-129632	9.2	PDGFRA, KIT
3	sunitinib32 9 9	11.2	PDGFRA, KIT
4	hydroxyurea32 9 9	11.1	PDGFRA, KIT
5	rapamycin32 42	10.1	PDGFRA, KIT
6	imatinib32 34 9 9	12.0	KIT, PDGFRA
7	phosphotyrosine32	8.8	KIT, PDGFRA

Biological processes related to gastrointestinal stromal tumor, somatic according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of phospholipase C activity	GO:010863	9.3	KIT, PDGFRA
2	cell chemotaxis	GO:060326	9.2	PDGFRA, KIT
3	positive regulation of phosphatidylinositol 3-kinase activity	GO:043552	9.2	PDGFRA, KIT
4	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	9.1	KIT, PDGFRA
5	positive regulation of cell proliferation	GO:008284	9.1	PDGFRA, KIT
6	peptidyl-tyrosine phosphorylation	GO:018108	9.0	PDGFRA, KIT
7	protein autophosphorylation	GO:046777	8.8	KIT, PDGFRA

Molecular functions related to gastrointestinal stromal tumor, somatic according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	transmembrane receptor protein tyrosine kinase activity	GO:004714	9.1	KIT, PDGFRA