MCID: GST050
MIFTS: 47

Gastrointestinal System Disease malady

Gastrointestinal diseases category

Aliases & Classifications for Gastrointestinal System Disease

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 55SNOMED-CT, 38NCIt, 33MeSH, 27ICD9CM, 25ICD10
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Gastrointestinal System Disease, Aliases & Descriptions:

Name: Gastrointestinal System Disease 9 11
Gastrointestinal Diseases 43 60
Digestive System Disorders 60
Alimentary System Disease 9
Gastrointestinal Disorder 9
 
Digestive System Disorder 9
Gastrointestinal Disease 9
Gastroenteropathy 9
Git Disease 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology9 DOID:77
NCIt38 C2990
MeSH33 D004066
ICD9CM27 520-579.99
ICD1025 11, K92.2, K92.8

Summaries for Gastrointestinal System Disease

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Disease Ontology:9 A disease of anatomical entity that is located in the gastrointestinal tract.

MalaCards based summary: Gastrointestinal System Disease, also known as gastrointestinal diseases, is related to esophageal cancer and vascular disease. An important gene associated with Gastrointestinal System Disease is CD19 (CD19 molecule), and among its related pathways are Nectin adhesion pathway and Thyroid cancer. The drugs belladonna alkaloids and dicyclomine and the compounds d-arginine and saikosaponin have been mentioned in the context of this disorder. Affiliated tissues include the gastrointestinal tract, and related mouse phenotypes are tumorigenesis and renal/urinary system.

Related Diseases for Gastrointestinal System Disease

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Diseases related to Gastrointestinal System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 390)
idRelated DiseaseScoreTop Affiliating Genes
1esophageal cancer30.0PTGS2, CDH1
2vascular disease29.4KNG1, NOS2, JUN
3pancreatic cancer29.3HRAS, BAX, CDH1, JUN, PTGS2
4irritable bowel syndrome10.3
5gastrojejunal ulcer10.3
6gastric ulcer10.3
7eosinophilic gastroenteritis10.2
8gastroenteritis10.2
9galactosemia10.2
10cholecystitis10.2
11abdominal wall defect10.2
12precursor b-cell acute lymphoblastic leukemia10.2DNTT, CD19
13cholestasis, benign recurrent intrahepatic10.2
14cholestasis, progressive familial intrahepatic 110.2
15perinatal intestinal perforation10.2
16perinatal necrotizing enterocolitis10.2
17pleurisy10.2KNG1, PTGS2
18angioedema10.2PTGS2, KNG1
19chronic lymphocytic leukemia10.1DNTT, CD19, BAX
20renal fibrosis10.1CDH1, KNG1
21protein-losing enteropathy10.1
22gastritis10.1
23dyspepsia10.1
24eating disorder10.1
25precursor t-cell acute lymphoblastic leukemia10.1HRAS, BAX, DNTT
26gallbladder cancer10.1BAX, CDH1
27appendicitis10.1
28congenital diaphragmatic hernia10.1
29congenital heart disease10.1KNG1, BAX, DNTT
30follicular adenoma10.1HRAS, CDH1
31thyroid carcinoma, papillary10.0BAX, CDH1, HRAS
32eye disease10.0BAX, DNTT, JUN
33cholestasis, benign recurrent intrahepatic, 210.0
34cholangitis, primary sclerosing10.0
35meconium ileus10.0
36cholestasis, progressive familial intrahepatic 210.0
37cholestasis, progressive familial intrahepatic 310.0
38intestinal obstruction10.0
39bladder cancer, somatic10.0BAX, CDH1, HRAS
40cystic fibrosis10.0
41hepatitis10.0
42systemic mastocytosis10.0
43mastocytosis10.0
44pleomorphic adenoma10.0HRAS, NOS2
45skin benign neoplasm10.0JUN, HRAS
46celiac disease10.0
47atopy10.0
48cyclic vomiting syndrome10.0
49leukemia, acute promyelocytic10.0BAX, DNTT, JUN
50myeloma10.0HRAS, DNTT, CD19, BAX

Graphical network of the top 20 diseases related to Gastrointestinal System Disease:



Diseases related to gastrointestinal system disease

Symptoms for Gastrointestinal System Disease

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Drugs & Therapeutics for Gastrointestinal System Disease

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Genetic Tests for Gastrointestinal System Disease

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Anatomical Context for Gastrointestinal System Disease

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FMA organs/tissues related to Gastrointestinal System Disease:

14
The gastrointestinal tract

Animal Models for Gastrointestinal System Disease or affiliated genes

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MGI Mouse Phenotypes related to Gastrointestinal System Disease:

35 (show all 16)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5PTGS2, NOS2, CD19, CDH1, HRAS
2MP:00053678.5PTGS2, BAX, NOS2, CD19, HRAS
3MP:00053888.3PTGS2, JUN, BAX, NOS2, HRAS
4MP:00053908.1PTGS2, JUN, BAX, NOS2, HRAS
5MP:00028738.1PTGS2, JUN, DNTT, CD19, CDH1, HRAS
6MP:00053798.0PTGS2, JUN, BAX, NOS2, CDH1, HRAS
7MP:00053858.0PTGS2, JUN, NOS2, CD19, CDH1, HRAS
8MP:00053867.9PTGS2, JUN, BAX, NOS2, CD19, HRAS
9MP:00036317.9HRAS, CD19, NOS2, BAX, JUN, PTGS2
10MP:00107717.9PTGS2, CLDN1, JUN, NOS2, CD19, CDH1
11MP:00053977.8PTGS2, JUN, DNTT, BAX, NOS2, CD19
12MP:00053877.5PTGS2, JUN, DNTT, BAX, NOS2, CD19
13MP:00053847.5PTGS2, JUN, BAX, NOS2, CD19, CDH1
14MP:00053787.5PTGS2, CLDN1, JUN, BAX, NOS2, CD19
15MP:00107687.4PTGS2, CLDN1, JUN, BAX, NOS2, CD19
16MP:00053767.1HRAS, PTGS2, CLDN1, JUN, BAX, KNG1

Publications for Gastrointestinal System Disease

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Variations for Gastrointestinal System Disease

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Expression for genes affiliated with Gastrointestinal System Disease

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Search GEO for disease gene expression data for Gastrointestinal System Disease.

Pathways for genes affiliated with Gastrointestinal System Disease

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Pathways related to Gastrointestinal System Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 61)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CDH1, CLDN1
29.7CDH1, HRAS
39.7HRAS, CDH1
49.7HRAS, JUN
59.7HRAS, JUN
6
Show member pathways
AhR pathway36
9.6JUN, BAX
79.6BAX, JUN
89.4HRAS, KNG1, BAX
9
Show member pathways
9.4JUN, CD19, HRAS
10
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
9.4HRAS, CD19, JUN
11
Show member pathways
9.4HRAS, CD19, JUN
12
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility58
Cytoskeleton remodeling Integrin outside in signaling58
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases58
Cell adhesion Tight junctions58
Development MAG dependent inhibition of neurite outgrowth58
9.4CLDN1, JUN, HRAS
139.4JUN, BAX, CD19
14
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes58
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway58
9.3JUN, BAX, HRAS
15
Show member pathways
9.3JUN, BAX, HRAS
16
Show member pathways
9.3JUN, BAX, HRAS
17
Show member pathways
Prostate Cancer36
Integrated Cancer pathway36
Steroid Biosynthesis36
9.3JUN, BAX, HRAS
189.3JUN, BAX, HRAS
19
Show member pathways
Apoptosis and survival BAD phosphorylation58
Development Alpha 2 adrenergic receptor activation of ERK58
Chemotaxis CXCR4 signaling pathway58
9.3JUN, BAX, HRAS
20
Show member pathways
9.3HRAS, BAX, JUN
219.3HRAS, BAX, JUN
22
Show member pathways
9.3HRAS, BAX, JUN
23
Show member pathways
Development ERBB family signaling58
Development GDNF family signaling58
9.3HRAS, CDH1, JUN
249.3HRAS, CDH1, JUN
25
Show member pathways
RAC1 signaling pathway36
9.3HRAS, CDH1, JUN
269.3JUN, CDH1, HRAS
279.2CDH1, BAX, JUN
28
Show member pathways
9.1HRAS, JUN, PTGS2
29
Show member pathways
9.1HRAS, JUN, PTGS2
309.1PTGS2, BAX, CDH1
31
Show member pathways
9.0HRAS, CD19, BAX, JUN
329.0BAX, JUN, PTGS2
33
Show member pathways
9.0HRAS, CDH1, JUN, CLDN1
34
Show member pathways
8.9JUN, BAX, CDH1, HRAS
35
Show member pathways
8.9JUN, BAX, CDH1, HRAS
36
Show member pathways
Signal transduction PTEN pathway58
8.9JUN, BAX, CDH1, HRAS
37
Show member pathways
8.9NOS2, JUN, PTGS2
388.9NOS2, JUN, PTGS2
39
Show member pathways
Immune response MIF in innate immunity response58
8.9NOS2, JUN, PTGS2
408.9PTGS2, JUN, NOS2
41
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.8JUN, BAX, NOS2, HRAS
42
Show member pathways
Prolactin Signaling Pathway36
Development Prolactin receptor signaling58
Leptin signaling pathway36
8.8JUN, BAX, NOS2, HRAS
43
Show member pathways
8.8PTGS2, JUN, CD19, HRAS
44
Show member pathways
Immune response BCR pathway58
Fc-epsilon receptor I signaling in mast cells36
8.8PTGS2, JUN, CD19, HRAS
45
Show member pathways
8.7PTGS2, JUN, BAX, HRAS
46
Show member pathways
Development EGFR signaling via PIP358
Development PDGF signaling via MAPK cascades58
Apoptosis and survival Anti apoptotic action of membrane bound ESR158
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases58
Development Neurotrophin family signaling58
Apoptosis and survival NGF signaling pathway58
Apoptosis and survival Role of CDK5 in neuronal death and survival58
8.7PTGS2, JUN, BAX, HRAS
478.7CDH1, JUN, CLDN1, PTGS2
48
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
8.6HRAS, NOS2, JUN, PTGS2
49
Show member pathways
8.3PTGS2, JUN, BAX, CDH1, HRAS
507.8HRAS, CDH1, NOS2, BAX, JUN, PTGS2

Compounds for genes affiliated with Gastrointestinal System Disease

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Compounds related to Gastrointestinal System Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 114)
idCompoundScoreTop Affiliating Genes
1d-arginine43 24 1211.8NOS2, KNG1
2saikosaponin439.8BAX, JUN
3ketorolac43 1210.6PTGS2, NOS2
4exisulind439.5CDH1, PTGS2, BAX
5sulindac sulfide439.4BAX, PTGS2, JUN
6vinblastine43 49 1211.4CDH1, BAX, JUN
7c2ceramide439.4BAX, NOS2, JUN
8cyclopentenone439.3PTGS2, JUN, NOS2
9silymarin439.2NOS2, JUN, PTGS2
10sulindac43 1210.2PTGS2, BAX, HRAS, CDH1
11gf 109203x43 5910.1PTGS2, HRAS, KNG1, JUN
1215-deoxy-delta-12,14-prostaglandin j2439.1JUN, NOS2, PTGS2
13mg 13243 5910.1JUN, BAX, NOS2, CDH1
1412-o-tetradecanoylphorbol 13-acetate439.0HRAS, CDH1, DNTT, JUN
154-hydroxynonenal43 2410.0NOS2, BAX, JUN
16troglitazone43 28 59 1212.0BAX, JUN, PTGS2, CDH1
17celecoxib43 59 28 49 24 1214.0BAX, PTGS2, CDH1, NOS2
18doxorubicin43 49 1211.0CD19, BAX, NOS2, CDH1, HRAS
19quercetin43 59 24 1211.9DNTT, NOS2, BAX, JUN
20pdtc438.9JUN, NOS2, PTGS2
21triptolide438.9BAX, JUN, NOS2, PTGS2
22ciglitazone43 289.9NOS2, PTGS2, BAX, JUN
23sulforaphane438.9NOS2, BAX, JUN, PTGS2
24wortmannin438.9BAX, HRAS, CDH1, JUN
25resveratrol43 59 24 1211.9BAX, PTGS2, JUN, NOS2
26indomethacin43 28 59 1211.9NOS2, KNG1, PTGS2, CDH1
27paraffin438.8HRAS, BAX, DNTT, CDH1
28irinotecan43 49 1210.8CDH1, PTGS2, BAX
29pd 98,059438.7HRAS, CDH1, PTGS2, JUN, BAX
30adenylate438.7HRAS, CDH1, NOS2, DNTT, KNG1
31arachidonic acid43 28 24 1211.6KNG1, DNTT, PTGS2, HRAS, CDH1
32herbimycin a43 599.6NOS2, JUN, CDH1, HRAS, PTGS2
33cisplatin43 49 59 1211.6HRAS, CDH1, BAX, PTGS2, DNTT
34actinomycin d438.5PTGS2, JUN, BAX, KNG1, NOS2
35egcg438.5NOS2, BAX, CDH1, JUN, PTGS2
36curcumin438.5JUN, BAX, NOS2, CDH1, PTGS2
37etoposide43 49 59 1211.5CDH1, BAX, PTGS2, DNTT, JUN
38n acetylcysteine438.5BAX, PTGS2, NOS2, CDH1, JUN
39sb 20358043 599.5CDH1, NOS2, BAX, JUN, PTGS2
40cycloheximide438.5BAX, JUN, KNG1, PTGS2, NOS2
41nitric oxide43 24 1210.3HRAS, NOS2, KNG1, PTGS2, DNTT
42butyrate438.3JUN, DNTT, ALPI, BAX, CDH1
43ly294002438.2CDH1, BAX, NOS2, JUN, PTGS2, HRAS
44dexamethasone43 49 28 1211.2PTGS2, NOS2, CDH1, DNTT, JUN
45vegf438.2CDH1, PTGS2, JUN, BAX, NOS2, HRAS
46estrogen438.1BAX, NOS2, HRAS, JUN, PTGS2, CDH1
47phosphatidylinositol437.9HRAS, ALPI, BAX, CDH1, KNG1, JUN
48genistein43 28 59 2 24 1212.9HRAS, CDH1, NOS2, PTGS2, JUN, BAX
49calcium43 49 24 1210.8HRAS, CLDN1, ALPI, KNG1, NOS2, CD19
50pge2437.7JUN, DNTT, KNG1, NOS2, CDH1, HRAS

GO Terms for genes affiliated with Gastrointestinal System Disease

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Cellular components related to Gastrointestinal System Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lateral plasma membraneGO:00163289.8CDH1, CLDN1

Biological processes related to Gastrointestinal System Disease according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of DNA replicationGO:00457409.8HRAS, JUN
2release of cytochrome c from mitochondriaGO:00018369.8JUN, BAX
3cellular response to UVGO:00346449.7BAX, PTGS2
4Fc-epsilon receptor signaling pathwayGO:00380959.6HRAS, CD19, JUN
5negative regulation of neuron apoptotic processGO:00435249.6HRAS, BAX, JUN
6positive regulation of neuron apoptotic processGO:00435259.5BAX, JUN
7learningGO:00076129.4JUN, PTGS2
8positive regulation of apoptotic processGO:00430659.2PTGS2, BAX, KNG1
9positive regulation of smooth muscle cell proliferationGO:00486619.1JUN, PTGS2
10response to drugGO:00424939.1CDH1, JUN, PTGS2
11inflammatory responseGO:00069549.0PTGS2, KNG1, NOS2

Products for genes affiliated with Gastrointestinal System Disease

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  • Antibodies
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  • Kits and Assays

Sources for Gastrointestinal System Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet