MCID: GST050
MIFTS: 55

Gastrointestinal System Disease malady

Gastrointestinal diseases category

Summaries for Gastrointestinal System Disease

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Wikipedia:64 The human gastrointestinal tract, or GI tract, is an organ system responsible for consuming and... more...

MalaCards based summary: Gastrointestinal System Disease, also known as gastrointestinal diseases, is related to esophageal cancer and vascular disease. An important gene associated with Gastrointestinal System Disease is CD19 (CD19 molecule), and among its related pathways are Nectin adhesion pathway and Thyroid cancer. The drugs sacrosidase and belladonna alkaloids and the compounds d-arginine and saikosaponin have been mentioned in the context of this disorder. Affiliated tissues include the gastrointestinal tract, and related mouse phenotypes are tumorigenesis and renal/urinary system.

Disease Ontology:9 A disease of anatomical entity that is located in the gastrointestinal tract.

Aliases & Classifications for Gastrointestinal System Disease

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Sources:
9Disease Ontology, 11DISEASES, 61UMLS, 44Novoseek, 56SNOMED-CT, 28ICD9CM, 34MeSH, 39NCIt, 26ICD10
See all sources

Gastrointestinal System Disease, Aliases & Descriptions:

Name: Gastrointestinal System Disease 9 11 61
Gastrointestinal Diseases 44 61
Digestive System Disorders 61
Alimentary System Diseases 61
Alimentary System Disease 9
 
Gastrointestinal Disorder 9
Digestive System Disorder 9
Gastrointestinal Disease 9
Gastroenteropathy 9
Git Disease 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology9 DOID:77
ICD9CM28 520-579.99
MeSH34 D004066
NCIt39 C2990
ICD1026 11, K92.2, K92.8

Related Diseases for Gastrointestinal System Disease

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Diseases related to Gastrointestinal System Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 495)
idRelated DiseaseScoreTop Affiliating Genes
1esophageal cancer30.0PTGS2, CDH1
2vascular disease29.4JUN, KNG1, NOS2
3pancreatic cancer29.3PTGS2, JUN, BAX, CDH1, HRAS
4gastrojejunal ulcer10.3
5gastric ulcer10.3
6irritable bowel syndrome10.3
7leukemia, acute lymphoblastic 310.2CD19, DNTT
8eosinophilic gastroenteritis10.2
9gastroenteritis10.2
10galactosemia10.2
11abdominal wall defect10.2
12pleurisy10.2KNG1, PTGS2
13cholestasis, progressive familial intrahepatic 110.2
14benign recurrent intrahepatic cholestasis10.2
15angioedema10.2KNG1, PTGS2
16chronic lymphocytic leukemia10.1DNTT, BAX, CD19
17renal fibrosis10.1KNG1, CDH1
18protein-losing enteropathy10.1
19gastritis10.1
20eosinophilic enteropathy10.1
21appendicitis10.1
22cholecystitis10.1
23gallbladder cancer10.1BAX, CDH1
24precursor t-cell acute lymphoblastic leukemia10.1DNTT, BAX, HRAS
25dyspepsia10.1
26eating disorder10.1
27congenital heart disease10.1DNTT, BAX, KNG1
28hepatitis10.1
29congenital diaphragmatic hernia10.1
30follicular adenoma10.1HRAS, CDH1
31papillary thyroid carcinoma10.1HRAS, CDH1, BAX
32bladder carcinoma in situ10.0PTGS2, CDH1, HRAS
33spiradenoma10.0BAX, DNTT, JUN
34bladder carcinoma10.0BAX, CDH1, HRAS
35benign recurrent intrahepatic cholestasis 210.0
36cholestasis, progressive familial intrahepatic 210.0
37cholestasis, progressive familial intrahepatic 310.0
38primary sclerosing cholangitis10.0
39meconium ileus in cystic fibrosis10.0
40skin benign neoplasm10.0JUN, HRAS
41acute promyelocytic leukemia10.0BAX, DNTT, JUN
42celiac disease10.0
43cyclic vomiting syndrome10.0
44atopy10.0
45myeloma10.0DNTT, BAX, CD19, HRAS
46crohn's disease10.0
47cystic fibrosis10.0
48systemic mastocytosis10.0
49collagenous colitis10.0
50hirschsprung's disease10.0

Graphical network of the top 20 diseases related to Gastrointestinal System Disease:



Diseases related to gastrointestinal system disease

Symptoms for Gastrointestinal System Disease

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Drugs & Therapeutics for Gastrointestinal System Disease

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Genetic Tests for Gastrointestinal System Disease

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Anatomical Context for Gastrointestinal System Disease

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FMA organs/tissues related to Gastrointestinal System Disease:

15
The gastrointestinal tract

Animal Models for Gastrointestinal System Disease or affiliated genes

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MGI Mouse Phenotypes related to Gastrointestinal System Disease:

36 (show all 16)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5PTGS2, NOS2, CD19, CDH1, HRAS
2MP:00053678.5PTGS2, BAX, NOS2, CD19, HRAS
3MP:00053888.3PTGS2, JUN, BAX, NOS2, HRAS
4MP:00053908.1PTGS2, JUN, BAX, NOS2, HRAS
5MP:00028738.1PTGS2, JUN, DNTT, CD19, CDH1, HRAS
6MP:00053798.0PTGS2, JUN, BAX, NOS2, CDH1, HRAS
7MP:00053858.0PTGS2, JUN, NOS2, CD19, CDH1, HRAS
8MP:00053867.9PTGS2, JUN, BAX, NOS2, CD19, HRAS
9MP:00036317.9HRAS, CD19, NOS2, BAX, JUN, PTGS2
10MP:00107717.9PTGS2, CLDN1, JUN, NOS2, CD19, CDH1
11MP:00053977.8PTGS2, JUN, DNTT, BAX, NOS2, CD19
12MP:00053877.5PTGS2, JUN, DNTT, BAX, NOS2, CD19
13MP:00053847.5PTGS2, JUN, BAX, NOS2, CD19, CDH1
14MP:00053787.5PTGS2, CLDN1, JUN, BAX, NOS2, CD19
15MP:00107687.4PTGS2, CLDN1, JUN, BAX, NOS2, CD19
16MP:00053767.1HRAS, PTGS2, CLDN1, JUN, BAX, KNG1

Publications for Gastrointestinal System Disease

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Variations for Gastrointestinal System Disease

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Expression for genes affiliated with Gastrointestinal System Disease

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Expression patterns in normal tissues for genes affiliated with Gastrointestinal System Disease

Search GEO for disease gene expression data for Gastrointestinal System Disease.

Pathways for genes affiliated with Gastrointestinal System Disease

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Pathways related to Gastrointestinal System Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CDH1, CLDN1
29.7CDH1, HRAS
39.7HRAS, CDH1
49.7HRAS, JUN
59.7HRAS, JUN
6
Show member pathways
AhR pathway37
9.6JUN, BAX
79.6BAX, JUN
89.4HRAS, KNG1, BAX
9
Show member pathways
9.4JUN, CD19, HRAS
10
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
9.4HRAS, CD19, JUN
11
Show member pathways
9.4HRAS, CD19, JUN
12
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility59
Cytoskeleton remodeling Integrin outside in signaling59
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases59
Cell adhesion Tight junctions59
Development MAG dependent inhibition of neurite outgrowth59
9.4CLDN1, JUN, HRAS
139.4JUN, BAX, CD19
14
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes59
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway59
9.3JUN, BAX, HRAS
15
Show member pathways
9.3JUN, BAX, HRAS
16
Show member pathways
9.3JUN, BAX, HRAS
17
Show member pathways
Prostate Cancer37
Integrated Cancer pathway37
Steroid Biosynthesis37
9.3JUN, BAX, HRAS
189.3JUN, BAX, HRAS
19
Show member pathways
Apoptosis and survival BAD phosphorylation59
Development Alpha 2 adrenergic receptor activation of ERK59
Chemotaxis CXCR4 signaling pathway59
9.3JUN, BAX, HRAS
20
Show member pathways
9.3HRAS, BAX, JUN
219.3HRAS, BAX, JUN
22
Show member pathways
9.3HRAS, BAX, JUN
23
Show member pathways
Development ERBB family signaling59
Development GDNF family signaling59
9.3HRAS, CDH1, JUN
249.3HRAS, CDH1, JUN
25
Show member pathways
RAC1 signaling pathway37
9.3HRAS, CDH1, JUN
269.3JUN, CDH1, HRAS
279.2CDH1, BAX, JUN
28
Show member pathways
9.1HRAS, JUN, PTGS2
29
Show member pathways
9.1HRAS, JUN, PTGS2
309.1PTGS2, BAX, CDH1
31
Show member pathways
9.0HRAS, CD19, BAX, JUN
329.0BAX, JUN, PTGS2
33
Show member pathways
9.0HRAS, CDH1, JUN, CLDN1
34
Show member pathways
8.9JUN, BAX, CDH1, HRAS
35
Show member pathways
8.9JUN, BAX, CDH1, HRAS
36
Show member pathways
Signal transduction PTEN pathway59
8.9JUN, BAX, CDH1, HRAS
37
Show member pathways
8.9NOS2, JUN, PTGS2
388.9NOS2, JUN, PTGS2
39
Show member pathways
Immune response MIF in innate immunity response59
8.9NOS2, JUN, PTGS2
408.9PTGS2, JUN, NOS2
41
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.8JUN, BAX, NOS2, HRAS
42
Show member pathways
Prolactin Signaling Pathway37
Development Prolactin receptor signaling59
Leptin signaling pathway37
8.8JUN, BAX, NOS2, HRAS
43
Show member pathways
8.8PTGS2, JUN, CD19, HRAS
44
Show member pathways
Immune response BCR pathway59
Fc-epsilon receptor I signaling in mast cells37
8.8PTGS2, JUN, CD19, HRAS
45
Show member pathways
8.7PTGS2, JUN, BAX, HRAS
46
Show member pathways
Development EGFR signaling via PIP359
Development PDGF signaling via MAPK cascades59
Apoptosis and survival Anti apoptotic action of membrane bound ESR159
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases59
Development Neurotrophin family signaling59
Apoptosis and survival NGF signaling pathway59
Apoptosis and survival Role of CDK5 in neuronal death and survival59
8.7PTGS2, JUN, BAX, HRAS
478.7CDH1, JUN, CLDN1, PTGS2
48
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways59
Immune response IL 1 signaling pathway59
8.6HRAS, NOS2, JUN, PTGS2
49
Show member pathways
8.3PTGS2, JUN, BAX, CDH1, HRAS
507.8HRAS, CDH1, NOS2, BAX, JUN, PTGS2

Compounds for genes affiliated with Gastrointestinal System Disease

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Compounds related to Gastrointestinal System Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 114)
idCompoundScoreTop Affiliating Genes
1d-arginine44 25 1211.8NOS2, KNG1
2saikosaponin449.8BAX, JUN
3ketorolac44 1210.6PTGS2, NOS2
4exisulind449.5CDH1, PTGS2, BAX
5sulindac sulfide449.4BAX, PTGS2, JUN
6vinblastine44 50 1211.4CDH1, BAX, JUN
7c2ceramide449.4BAX, NOS2, JUN
8cyclopentenone449.3PTGS2, JUN, NOS2
9silymarin449.2NOS2, JUN, PTGS2
10sulindac44 1210.2PTGS2, BAX, HRAS, CDH1
11gf 109203x44 6010.1PTGS2, HRAS, KNG1, JUN
1215-deoxy-delta-12,14-prostaglandin j2449.1JUN, NOS2, PTGS2
13mg 13244 6010.1JUN, BAX, NOS2, CDH1
1412-o-tetradecanoylphorbol 13-acetate449.0HRAS, CDH1, DNTT, JUN
154-hydroxynonenal44 2510.0NOS2, BAX, JUN
16troglitazone44 29 60 1212.0BAX, JUN, PTGS2, CDH1
17celecoxib44 60 29 50 25 1214.0BAX, PTGS2, CDH1, NOS2
18doxorubicin44 50 1211.0CD19, BAX, NOS2, CDH1, HRAS
19quercetin44 60 25 1211.9DNTT, NOS2, BAX, JUN
20pdtc448.9JUN, NOS2, PTGS2
21triptolide448.9BAX, JUN, NOS2, PTGS2
22ciglitazone44 299.9NOS2, PTGS2, BAX, JUN
23sulforaphane448.9NOS2, BAX, JUN, PTGS2
24wortmannin448.9BAX, HRAS, CDH1, JUN
25resveratrol44 60 25 1211.9BAX, PTGS2, JUN, NOS2
26indomethacin44 29 60 1211.9NOS2, KNG1, PTGS2, CDH1
27paraffin448.8HRAS, BAX, DNTT, CDH1
28irinotecan44 50 1210.8CDH1, PTGS2, BAX
29pd 98,059448.7HRAS, CDH1, PTGS2, JUN, BAX
30adenylate448.7HRAS, CDH1, NOS2, DNTT, KNG1
31arachidonic acid44 29 25 1211.6KNG1, DNTT, PTGS2, HRAS, CDH1
32herbimycin a44 609.6NOS2, JUN, CDH1, HRAS, PTGS2
33cisplatin44 50 60 1211.6HRAS, CDH1, BAX, PTGS2, DNTT
34actinomycin d448.5PTGS2, JUN, BAX, KNG1, NOS2
35egcg448.5NOS2, BAX, CDH1, JUN, PTGS2
36curcumin448.5JUN, BAX, NOS2, CDH1, PTGS2
37etoposide44 50 60 1211.5CDH1, BAX, PTGS2, DNTT, JUN
38n acetylcysteine448.5BAX, PTGS2, NOS2, CDH1, JUN
39sb 20358044 609.5CDH1, NOS2, BAX, JUN, PTGS2
40cycloheximide448.5BAX, JUN, KNG1, PTGS2, NOS2
41nitric oxide44 25 1210.3HRAS, NOS2, KNG1, PTGS2, DNTT
42butyrate448.3JUN, DNTT, ALPI, BAX, CDH1
43ly294002448.2CDH1, BAX, NOS2, JUN, PTGS2, HRAS
44dexamethasone44 50 29 1211.2PTGS2, NOS2, CDH1, DNTT, JUN
45vegf448.2CDH1, PTGS2, JUN, BAX, NOS2, HRAS
46estrogen448.1BAX, NOS2, HRAS, JUN, PTGS2, CDH1
47phosphatidylinositol447.9HRAS, ALPI, BAX, CDH1, KNG1, JUN
48genistein44 29 60 3 25 1212.9HRAS, CDH1, NOS2, PTGS2, JUN, BAX
49calcium44 50 25 1210.8HRAS, CLDN1, ALPI, KNG1, NOS2, CD19
50pge2447.7JUN, DNTT, KNG1, NOS2, CDH1, HRAS

GO Terms for genes affiliated with Gastrointestinal System Disease

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Cellular components related to Gastrointestinal System Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lateral plasma membraneGO:0163289.8CDH1, CLDN1

Biological processes related to Gastrointestinal System Disease according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of DNA replicationGO:0457409.8HRAS, JUN
2release of cytochrome c from mitochondriaGO:0018369.8JUN, BAX
3cellular response to UVGO:0346449.7BAX, PTGS2
4Fc-epsilon receptor signaling pathwayGO:0380959.6HRAS, CD19, JUN
5negative regulation of neuron apoptotic processGO:0435249.6HRAS, BAX, JUN
6positive regulation of neuron apoptotic processGO:0435259.5BAX, JUN
7learningGO:0076129.4JUN, PTGS2
8positive regulation of apoptotic processGO:0430659.2PTGS2, BAX, KNG1
9positive regulation of smooth muscle cell proliferationGO:0486619.1JUN, PTGS2
10response to drugGO:0424939.1CDH1, JUN, PTGS2
11inflammatory responseGO:0069549.0PTGS2, KNG1, NOS2

Products for genes affiliated with Gastrointestinal System Disease

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Sources for Gastrointestinal System Disease

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet