Gastrointestinal System Disease malady

Wikipedia: The human gastrointestinal tract is the stomach and intestine, sometimes including all the structures...⁴⁴ more...

MalaCards: Gastrointestinal System Disease, also known as gastrointestinal diseases, is related to nervous system disease and central nervous system disease. An important gene associated with Gastrointestinal System Disease is NPS (neuropeptide S), and among its related pathways are Bacterial infections in CF airways and Th1 Differentiation. The drugs prednisolone acetate and prednisolone and the compounds ionomycin and isoproterenol have been mentioned in the context of this disorder. Affiliated tissues include the gastrointestinal tract, and related mouse phenotypes are respiratory system and craniofacial.

Disease Ontology: A disease of anatomical entity that is located in the gastrointestinal tract.⁶

Aliases & Descriptions:

gastrointestinal system disease 6 gastrointestinal diseases 32 43 digestive system disorders 43 digestive system disorder 6 gastrointestinal disorder 6

alimentary system disease 6 gastrointestinal disease 6 gastroenteropathy 6 systemic disease 43 git disease 6

Diseases related to gastrointestinal system disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 968)

id	Related Disease	Score	Top Affiliating Genes
1	nervous system disease	31.3	ITGAM, IL18, IL1B, IL6, CCL2, NOS2
2	central nervous system disease	31.0	ITGAM, IL18, IL1B, IL6, CCL2, NOS2
3	lymphatic system disease	29.0	MS4A1, CD79A, CD4, CD34, IL2, IL6
4	syphilis	27.3	CD79A, CD4, FN1, DDX41
5	intermediate uveitis	27.0	IL2RA, IFNG, CXCR3
6	pancreatic cancer	26.8	CHGA, MAPK1, SST, SRC, CTNNB1, NFKBIA
7	meningoencephalitis	26.8	CD79A, CD4, IL6, CCL5, HSPG2
8	diabetic macular edema	26.7	IL6, CCL2, ICAM1, SST
9	constipation	26.5	KIT, CHGA, GUSB, PTGS2, CYP3A4, SST
10	bacteriuria	26.2	CD79A, IL6, IL8, TLR4
11	cholestasis	26.1	PCNA, BCL2, BAX, LAP3, IL2RA, IL6
12	multiple sclerosis	26.0	CD40, IL1B, IL1RN, IL2RA, IFNG, ICAM1
13	hemophagocytic lymphohistiocytosis	25.6	IL18, IL2, IL2RA, IL8, CCL2, CCL5
14	complex regional pain syndrome	25.3	IL1B, IL6, CCL5, IFNG, CALCA, TGFB1
15	pemphigus vulgaris	25.3	CD79A, MMP9, IL1B, IL1RN, IL2, IL4
16	hyperhomocysteinemia	25.2	IL18, IL1B, IL1RN, IL6, IL8, CCL2
17	skin disease	25.2	SELL, CD79A, CD40, IL18, IL4, IL8
18	gastroesophageal reflux disease	25.2	BCL2, IL1B, IL1RN, IL6, IL8, CCL2
19	vascular disease	24.9	ITGAM, MMP9, MAPK1, CCL2, ICAM1, NOS2
20	congenital heart defect	24.8	CD40, IL6, HSPA4, SRC, NOS2, TTR
21	muscular dystrophy	24.7	BCL2, LAP3, CD80, MMP2, HSPG2, HSPA4
22	irritable bowel syndrome	24.6	CHGA, CD79A, FOS, IL1RN, IL2, IL4
23	acne	24.3	MMP2, MMP9, IL18, IL1RN, IL4, IL8
24	neurodegenerative disease	24.3	BCL2, GUSB, IL1B, MAPK1, HSPA4, NOS2
25	immunodeficiency	24.0	SELL, MYD88, CD28, CD79A, CD4, CD80
26	hyperparathyroidism	23.9	PCNA, CHGA, BAX, IL2, IL2RA, IL4
27	systemic lupus erythematosus	23.7	CD28, CD79A, CD86, CD4, CD80, CD40
28	wegener's granulomatosis	23.4	CD28, CD86, CD80, CD40, IL18, IL2RA
29	pemphigus	22.8	BAX, MS4A1, CD79A, CD40, MMP9, IL1B
30	anaplastic large cell lymphoma	22.4	KIT, PCNA, BCL2, CD4, CD44, IL2
31	amyloidosis	22.1	BCL2, SAA1, CD79A, CD40, MMP9, FOS
32	amyotrophic lateral sclerosis	21.6	SELL, BCL2, CHGA, BAX, CD79A, MMP2
33	uveitis	20.9	SELL, CD79A, CD4, CD40, GUSB, IL18
34	measles	20.6	MYD88, MS4A1, CD28, CD79A, CD4, IL1B
35	hypersensitivity reaction type ii disease	20.6	SELL, MYD88, MS4A1, CD28, CD79A, CD86
36	homocysteine	20.5	PCNA, MS4A1, MMP2, MMP9, FOS, IL18
37	celiac disease	20.1	SELL, CD28, CD79A, CD80, IL18, IL1B
38	diabetic retinopathy	19.7	SELL, CD79A, ITGAM, MMP2, MMP9, FN1
39	anemia	18.3	KIT, PCNA, SELL, BCL2, CHGA, SAA1
40	acute pancreatitis	18.1	BCL2, BAX, CD79A, ITGAM, MMP2, MMP9
41	vasculitis	17.5	SELL, MS4A1, CD28, CD79A, CD86, CD4
42	neuropathy	17.4	CHGA, CD79A, CD4, CD80, MMP2, MMP9
43	gingivitis	16.2	PCNA, SELL, MYD88, BCL2, MS4A1, CD79A
44	lupus erythematosus	16.0	PCNA, SELL, MYD88, BCL2, CHGA, BAX
45	psoriasis	15.4	PCNA, BCL2, BAX, CD28, CD79A, CD86
46	colon cancer	14.8	PCNA, SELL, MYD88, BCL2, CHGA, BAX
47	hepatitis	13.7	KIT, PCNA, SELL, MYD88, BCL2, CHGA
48	granulocytopenia	13.7	SELL, ITGAM, CSF2
49	lactose intolerance	13.7	CD79A, GLB1, LTF, CSN1S1
50	idiopathic myopathy	13.7	CCL2, CCL5, TGM2

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 belladonna, belladonna alkaloids, belladonna extract, belladonna leaf, dicyclomine, dicyclomine hydrochloride, polymyxin b, polymyxin b sulfate, prednisolone, prednisolone acetate, prednisolone acetate pwdr [va product], prednisolone pwdr [va product], prednisolone sodium phosphate, prednisolone tebutate, prednisone, prednisone pwdr [va product], sacrosidase

FMA organs/tissues related to gastrointestinal system disease:

¹¹

MGI Mouse Phenotypes related to gastrointestinal system disease:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.5	SELL, CALCA, PTPRC
2	craniofacial phenotype	MP:0005382	10.1	CSF2, TYRP1, PTH, HSPG2, GUSB, KIT
3	endocrine/exocrine gland phenotype	MP:0005379	9.8	PTH, PER2, IFNG, IL2, GUSB, SELL
4	no phenotypic analysis	MP:0003012	9.3	PER2, TGM2, CTNNB1, SST, PTGS2, CD44
5	renal/urinary system phenotype	MP:0005367	9.2	KIT, MYD88, BCL2, CHGA, BAX, GLB1
6	hematopoietic system phenotype	MP:0005397	9.2	PTH, PTPRC, TGFBI, TGM2, CSF2, PER2
7	liver/biliary system phenotype	MP:0005370	9.1	TLR4, PTPRC, GLB1, HSPG2, IFNG, IL6
8	pigmentation phenotype	MP:0001186	9.1	TYRP1, CTNNB1, SRC, CCL2, CDKN2A, BCL2
9	hearing/vestibular/ear phenotype	MP:0005377	8.7	CALCA, CTNNB1, NFKB1, TYRP1, TLR4, HSPG2
10	limbs/digits/tail phenotype	MP:0005371	8.7	TLR4, CTNNB1, SRC, PTH, HSPG2, GUSB
11	other phenotype	MP:0005395	8.5	CSF2, CXCR3, STAT3, NOS2, PTGS2, HSPG2
12	nervous system phenotype	MP:0003631	8.3	CD44, ITGAM, MMP2, FOS, MAPK1, HSPG2
13	normal phenotype	MP:0002873	8.1	PTPRC, SST, NFKBIA, ELANE, DNTT, STAT3
14	integument phenotype	MP:0010771	8.0	BCL2, CD4, CD34, CD44, FOS, GUSB
15	skeleton phenotype	MP:0005390	7.7	PTH, PTPRC, SRC, CTNNB1, NFKB1, TYRP1
16	adipose tissue phenotype	MP:0005375	7.6	NOS2, TLR4, TGFB1, STAT3, CSF2, PTGS2
17	immune system phenotype	MP:0005387	7.3	KIT, IFNG, HSPG2, PTH, PTPRC, SRC
18	digestive/alimentary phenotype	MP:0005381	7.0	IL18, CCL2, IFNG, HSPG2, PTPRC, SST
19	growth/size phenotype	MP:0005378	6.9	TLR4, TGFBI, STAT3, CSF2, PER2, EHD3
20	mortality/aging	MP:0010768	6.6	MYD88, NOS2, NFKBIA, ELANE, TYRP1, TLR4
21	behavior/neurological phenotype	MP:0005386	6.5	NOS2, CTNNB1, SRC, SST, GLB1, NFKB1
22	reproductive system phenotype	MP:0005389	6.3	IL6, MAPK1, CCL2, IFNG, GLB1, PTGS2
23	vision/eye phenotype	MP:0005391	5.3	SRC, PTGS2, HSPG2, ICAM1, CTNNB1, NOS2
24	muscle phenotype	MP:0005369	5.3	IFNG, ICAM1, HSPG2, PTGS2, CTNNB1, NOS2
25	tumorigenesis	MP:0002006	4.7	FOS, FN1, IL1B, IL2, IL6, CCL2
26	cardiovascular system phenotype	MP:0005385	4.2	PTH, GAPDH, EHD3, CTNNB1, NOS2, TLR4
27	homeostasis/metabolism phenotype	MP:0005376	3.8	IL1RN, NFKBIA, LTF, ELANE, TYRP1, TTR
28	cellular phenotype	MP:0005384	2.0	KIT, PCNA, SELL, MYD88, EHD3, BCL2

Genes related to gastrointestinal system disease according to GeneCards:

(show top 50)    (show all 74)

id	Symbol	Description	Score	GeneCards Section Context
1	NPS	neuropeptide S	11.0
2	LYZ	lysozyme	11.0
3	EHD3	EH-domain containing 3	11.0
4	LAP3	leucine aminopeptidase 3	11.0
5	DNTT	deoxynucleotidyltransferase, terminal	11.0
6	PER2	period homolog 2 (Drosophila)	11.0
7	PTH	parathyroid hormone	11.0
8	GLB1	galactosidase, beta 1	11.0
9	SAA1	serum amyloid A1	11.0
10	UBA52	ubiquitin A-52 residue ribosomal protein fusion product 1	11.0
11	TGFBI	transforming growth factor, beta-induced, 68kDa	11.0
12	TYRP1	tyrosinase-related protein 1	11.0
13	MS4A1	membrane-spanning 4-domains, subfamily A, member 1	11.0
14	DDX41	DEAD (Asp-Glu-Ala-Asp) box polypeptide 41	11.0
15	MYD88	myeloid differentiation primary response gene (88)	11.0
16	TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	11.0
17	GUSB	glucuronidase, beta	11.0
18	ITGAM	integrin, alpha M (complement component 3 receptor 3 subunit)	11.0
19	CD28	CD28 molecule	11.0
20	NLRP1	NLR family, pyrin domain containing 1	11.0
21	SELL	selectin L	11.0
22	CXCR3	chemokine (C-X-C motif) receptor 3	11.0
23	CD34	CD34 molecule	11.0
24	TAC1	tachykinin, precursor 1	11.0
25	CD80	CD80 molecule	11.0
26	CD86	CD86 molecule	11.0
27	CSN1S1	casein alpha s1	11.0
28	CHGA	chromogranin A (parathyroid secretory protein 1)	11.0
29	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	11.0
30	SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	11.0
31	LTF	lactotransferrin	11.0
32	SST	somatostatin	11.0
33	TTR	transthyretin	11.0
34	TLR4	toll-like receptor 4	11.0
35	PCNA	proliferating cell nuclear antigen	11.0
36	NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	11.0
37	NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	11.0
38	PTPRC	protein tyrosine phosphatase, receptor type, C	11.0
39	CD44	CD44 molecule (Indian blood group)	11.0
40	STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	11.0
41	MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	11.0
42	FOS	FBJ murine osteosarcoma viral oncogene homolog	11.0
43	HSPG2	heparan sulfate proteoglycan 2	11.0
44	HSPA4	heat shock 70kDa protein 4	11.0
45	GAPDH	glyceraldehyde-3-phosphate dehydrogenase	11.0
46	CSF2	colony stimulating factor 2 (granulocyte-macrophage)	11.0
47	CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	11.0
48	FN1	fibronectin 1	11.0
49	ELANE	elastase, neutrophil expressed	11.0
50	CYP3A4	cytochrome P450, family 3, subfamily A, polypeptide 4	11.0

Pathways related to gastrointestinal system disease according to GeneDecks:

(show top 50)    (show all 216)

id	Pathway	Score	Top Affiliating Genes
1	Bacterial infections in CF airways41	10.1	MYD88
2	Th1 Differentiation37	9.0	TLR4, IFNG, IL2, IL18, FOS, CD4
3	NFAT Signaling and Lymphocyte Interactions36	9.0	CD4, BAX, BCL2, CD80, CCL2, IL4
4	Hematopoietic cell lineage20	8.9	IL2RA, IL1B, ITGAM, CSF2, DNTT, IL6
5	Regulation of eIF4 and p70S6K36	8.9	CD80, CCL5, ITGAM, IL6, IL4, IL2
6	Immune response_Bacterial infections in normal airways41	8.8	NFKBIA, MYD88, IFNG, NOS2, IL1B
7	Cytokine production by Th17 cells in CF41	8.8	STAT3, MYD88, IL6, CSF2, ICAM1, NFKB1
8	Cytokine production by Th17 cells in CF (Mouse model)41	8.5	IL6, NFKBIA, MYD88, STAT3, TGFB1, NFKB1
9	Endothelin-1 Signaling Pathway36	8.4	SRC, CCL5, MAPK1, IL6, IL4, IL2
10	Akt Signaling36	8.4	IL2RA, IL4, IL6, CCL2, CSF2, CXCR3
11	IL-6 Pathway36	8.2	STAT3, BAX, CSF2, CCL5, CCL2, MAPK1
12	Measles20	8.0	STAT3, NFKBIA, NFKB1, IFNG, IL2RA, TLR4
13	T cell receptor signaling pathway20	8.0	PTPRC, NFKB1, CSF2, IFNG, MAPK1, IL4
14	NOD-like receptor signaling pathway20	7.9	NFKB1, NFKBIA, NLRP1, CCL5, CCL2, MAPK1
15	Toll-like receptor signaling pathway20	7.9	CD86, TLR4, NFKBIA, CD80, CD40, FOS
16	Pathways in cancer20	7.9	MAPK1, CTNNB1, NOS2, NFKBIA, TGFB1, STAT3
17	Immune response IL-1 signaling pathway10	7.9	FOS, IL6, IL8, PTGS2, NOS2, NFKB1
18	Immune response_IL-1 signaling pathway41	7.8	NFKB1, MYD88, UBA52, FOS, IL1B, IL6
19	Colorectal Cancer Metastasis36	7.7	BAX, IFNG, NFKB1, TLR4, CTNNB1, TGFB1
20	ERK Signaling36	7.7	IL2, IL1B, IL18, FN1, ITGAM, CD80
21	Amoebiasis20	7.6	CSF2, TGFB1, TLR4, NOS2, IL8, IL6
22	Malaria20	7.6	TGFB1, TLR4, ICAM1, MYD88, CD40, IL18
23	Molecular Mechanisms of Cancer36	7.6	ITGAM, FOS, FN1, IL2, IL6, MAPK1
24	Leishmaniasis20	7.5	MYD88, ITGAM, FOS, IL1B, IL4, MAPK1
25	Immune response MIF in innate immunity response10	7.5	NOS2, NFKB1, NFKBIA, TLR4, MYD88, IFNG
26	Pertussis20	7.5	NOS2, TLR4, NFKB1, MYD88, MAPK1, FOS
27	Immune response_MIF in innate immunity response41	7.5	IFNG, IL8, IL6, IL1B, MYD88, PTGS2
28	Chagas disease (American trypanosomiasis)20	7.5	MYD88, FOS, IL1B, IL6, MAPK1, CCL2
29	PGC1Alpha Pathway36	7.5	CCL5, IL8, IL4, IL2, BAX, IL1B
30	Rheumatoid arthritis20	7.2	CSF2, TGFB1, IL18, FOS, CD80, CD86
31	Immune response_MIF-mediated glucocorticoid regulation41	7.2	MAPK1, IL8, IL6, IL2, FOS, IFNG
32	Immune response MIF-mediated glucocorticoid regulation10	7.2	NFKBIA, NFKB1, NOS2, PTGS2, ICAM1, IFNG
33	Influenza A20	7.2	MYD88, IL18, IL1B, IL6, MAPK1, CCL2
34	Tuberculosis20	6.9	TGFB1, MYD88, BCL2, BAX, ITGAM, IL18
35	SOCS Pathway36	6.8	CD80, CD4, BAX, BCL2, IL1B, IL2
36	all-trans-Retinoic Acid Signaling in Brain36	6.7	CCL2, PTGS2, CSF2, IL6, IL4, IL2
37	PEDF Induced Signaling36	6.4	IL8, MAPK1, CCL2, CCL5, NFKB1, NFKBIA
38	Cytokine-cytokine receptor interaction20	6.4	IL2, IL2RA, IL6, IL8, CCL2, CCL5
39	PAK Pathway36	6.3	IL2RA, IL4, CD80, IL18, IL1B, KIT
40	MIF Mediated Glucocorticoid Regulation36	6.1	IL8, CCL5, PTGS2, NFKB1, NFKBIA, TLR4
41	TGF-Beta Pathway36	6.1	IL2, IL2RA, IL4, IL6, IL8, MAPK1
42	p38 Signaling36	6.1	CD4, CD80, IL18, IL1B, IL2, IL2RA
43	STAT3 Pathway36	6.0	BCL2, BAX, CD28, CD4, CD80, IL18
44	MIF Regulation of Innate Immune Cells36	6.0	BCL2, BAX, CD80, FOS, IL18, IL1B
45	MAPK Family Pathway36	5.9	BCL2, BAX, CD4, CD80, IL18, IL1B
46	Tec Kinases Signaling36	5.9	MYD88, BCL2, BAX, CD28, NFKB1, TLR4
47	Glucocorticoid Receptor Signaling36	5.9	MAPK1, IL8, IL6, IL4, IL2RA, IL2
48	Rho Family GTPases36	5.9	FOS, CSF2, TGFB1, NFKB1, HSPG2, FN1
49	Antioxidant Action of Vitamin-C36	5.5	IL2RA, IL4, IL6, IL8, MAPK1, CCL2
50	JAK-STAT Pathway36	5.3	KIT, BCL2, BAX, CD4, CD80, FOS

Compounds related to gastrointestinal system disease according to GeneDecks:

(show top 50)    (show all 472)

id	Compound	Score	Top Affiliating Genes
1	ionomycin32	10.1	FOS, CD40, PTPRC, NFKBIA, CSF2
2	isoproterenol32 9 9	11.1	CSF2, ELANE, LTF, NOS2, SST, PTH
3	calcitriol32 42 9 18 9	13.0	CD44, ITGAM, FOS, CSF2, NFKBIA, SRC
4	atorvastatin32 34 9 18 9	13.0	IL2RA, IL1RN, IL18, MMP9, MMP2, ITGAM
5	arginine32	8.8	CSN1S1, CXCR3, TAC1, TGFBI, TTR, NFKBIA
6	phorbol32	8.6	CSF2, ICAM1, MAPK1, IL2RA, FN1, FOS
7	estrogen32	8.5	TTR, ELANE, LTF, NOS2, PTH, CALCA
8	n acetylcysteine32	8.5	SRC, PTPRC, IL2RA, IL18, FOS, MMP9
9	doxorubicin32 34 9 9	11.3	NFKBIA, CTNNB1, SRC, SST, CYP3A4, HSPA4
10	sb 20358032 42	9.2	IFNG, CCL5, IL6, FOS, MMP9, MMP2
11	prednisolone32 9 9	10.1	GAPDH, CSN1S1, CYP3A4, IFNG, IL6, IL2RA
12	thalidomide32 42 9 9	11.0	NFKBIA, NFKB1, PTGS2, IFNG, CCL5, IL6
13	norepinephrine32 9 18 9	11.0	CALCA, CCL2, IL6, IL2RA, IL1RN, IL18
14	aspirin32 34 18	9.8	PCNA, PTGS2, HSPA4, HSPG2, CCL5, IL2RA
15	matrigel32	7.7	IL8, IL18, FN1, MMP9, MMP2, CD44
16	polymyxin b32	7.7	LTF, ICAM1, IFNG, CCL2, IL8, IL6
17	leukotriene b432 42 18	9.7	CSF2, ELANE, LTF, CCL5, CCL2, IL8
18	cytochalasin d32 42	8.6	LTF, CTNNB1, SRC, ICAM1, CCL5, CCL2
19	fluticasone propionate32 42 9 9	10.6	MMP9, IL1B, CSF2, ELANE, NFKBIA, CYP3A4
20	il-1232	7.5	CSF2, IFNG, CCL2, IL8, IL6, IL4
21	mg 13232 42	8.5	GAPDH, NFKBIA, NOS2, HSPA4, ICAM1, MAPK1
22	paclitaxel32 34 9 9	10.5	SRC, KIT, CYP3A4, HSPA4, MAPK1, IL2RA
23	polyinosinic-polycytidylic acid32	7.3	IL6, IL4, IL2, IL18, CD40, STAT3
24	cysteine32	7.2	GAPDH, CSN1S1, CSF2, TGFBI, ELANE, LTF
25	tacrolimus32 34 9 9	10.2	GAPDH, CXCR3, TGFB1, PCNA, CD28, CD79A
26	wortmannin32 42	8.1	CSF2, CXCR3, STAT3, CD80, CD86, CD28
27	oxygen32 18	8.1	ITGAM, CD44, CD80, CDKN2A, BAX, BCL2
28	simvastatin32 34 42 9 18 9	12.0	TLR4, NFKBIA, CYP3A4, HSPG2, ICAM1, IFNG
29	gm-csf32	6.8	ICAM1, IFNG, CCL5, CCL2, IL8, IL6
30	5fluorouracil32	6.8	CSF2, BCL2, PCNA, KIT, BAX, CDKN2A
31	ciglitazone32	6.8	CCL2, MAPK1, IL8, IL6, IL1B, MMP9
32	histamine32 18	7.7	CSN1S1, IL2, IL1RN, IL18, GUSB, ITGAM
33	pentoxifylline32 9 9	8.6	IFNG, IL8, IL6, IL4, IL2RA, IL2
34	adenylate32	6.5	HSPA4, HSPG2, MAPK1, IL4, IL2RA, IL1RN
35	paraffin32	6.5	IL4, IL2RA, FN1, MMP9, MMP2, CD44
36	hydrocortisone32 9 9	8.5	CSF2, CXCR3, ELANE, LTF, CD40, SST
37	cisplatin32 34 9 9	9.5	MAPK1, IL2RA, IL2, IL18, FN1, CD44
38	troglitazone32 42 9 9	9.4	TGFB1, BCL2, BAX, CYP3A4, PTGS2, ICAM1
39	il 1032	6.3	CCL2, IL8, IL6, IL4, IL2RA, IL2
40	neopterin32	6.3	CSF2, TTR, ELANE, LTF, ICAM1, IFNG
41	lactate32	5.9	DNTT, TGFB1, TLR4, TTR, ELANE, NFKBIA
42	butyrate32	5.8	CSF2, DNTT, TGFB1, NFKBIA, CTNNB1, HSPA4
43	nitric oxide32 9 18 9	8.6	IL6, IL1RN, IL1B, IL18, ITGAM, CD44
44	triptolide32	5.5	NOS2, PTGS2, ICAM1, IFNG, CCL5, CCL2
45	indomethacin32 9 9	7.4	TGFB1, IL1B, IL18, FN1, ITGAM, CD40
46	retinoic acid32 42 18	7.2	IFNG, BAX, CHGA, SELL, KIT, LAP3
47	herbimycin a32 42	5.2	NFKBIA, IL2, IL1B, FN1, FOS, MMP9
48	actinomycin d32	3.0	TAC1, TGFB1, TLR4, LTF, NFKBIA, NOS2
49	genistein32 9 18 9	5.5	CSN1S1, CSF2, STAT3, TLR4, TTR, NFKBIA
50	dexamethasone32 42 34 9 9	5.3	STAT3, TAC1, DNTT, TGFB1, TLR4, TTR

Cellular components related to gastrointestinal system disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:009897	8.2	CXCR3, CD79A, CD28, SELL, KIT, CD86
2	plasma membrane	GO:005886	7.3	CTNNB1, SRC, PTPRC, HSPG2, ICAM1, NFKBIA
3	cytoplasm	GO:005737	6.0	TLR4, TTR, NFKBIA, NFKB1, NOS2, TGFB1
4	extracellular space	GO:005615	4.9	LYZ, CSF2, TAC1, TGFBI, TGFB1, TTR
5	extracellular region	GO:005576	4.9	ELANE, LTF, SST, PTH, CALCA, TTR

Biological processes related to gastrointestinal system disease according to GeneDecks:

(show top 50)    (show all 96)

id	Name	GO ID	Score	Top Affiliating Genes
1	leukocyte migration	GO:050900	10.0	ICAM1, SRC, FN1, ITGAM, SELL, ELANE
2	positive regulation of interleukin-2 biosynthetic process	GO:045086	10.0	CD86, CD4, CD80, CD28, IL1B
3	toll-like receptor 1 signaling pathway	GO:034130	10.0	TLR4, MYD88, UBA52, FOS, MAPK1, NFKB1
4	toll-like receptor 2 signaling pathway	GO:034134	10.0	MAPK1, NFKBIA, FOS, TLR4, NFKB1, UBA52
5	MyD88-dependent toll-like receptor signaling pathway	GO:002755	10.0	MAPK1, NFKB1, NFKBIA, TLR4, FOS, MYD88
6	Toll signaling pathway	GO:008063	10.0	NFKB1, NFKBIA, MAPK1, TLR4, FOS, MYD88
7	toll-like receptor 4 signaling pathway	GO:034142	10.0	UBA52, FOS, MAPK1, NFKB1, NFKBIA, TLR4
8	toll-like receptor signaling pathway	GO:002224	10.0	TLR4, NFKBIA, MAPK1, NFKB1, MYD88, UBA52
9	positive regulation of interleukin-17 production	GO:032740	9.9	MYD88, TGFB1, IL2, IL18
10	TRIF-dependent toll-like receptor signaling pathway	GO:035666	9.9	TLR4, NFKBIA, NFKB1, MAPK1, UBA52, FOS
11	positive regulation of smooth muscle cell proliferation	GO:048661	9.8	ELANE, TGM2, CCL5, PTGS2, IL6, MYD88
12	toll-like receptor 3 signaling pathway	GO:034138	9.8	MAPK1, NFKB1, NFKBIA, FOS, UBA52, TLR4
13	B cell proliferation	GO:042100	9.8	CD40, CD79A, PTPRC, BCL2
14	acute-phase response	GO:006953	9.8	IL6, STAT3, FN1, IL1RN, SAA1
15	positive regulation of gene expression	GO:010628	9.7	IL18, CD44, CD34, KIT, CCL5, CSF2
16	cellular response to mechanical stimulus	GO:071260	9.7	CD40, MYD88, TLR4, NFKB1, IL1B, IL18
17	monocyte chemotaxis	GO:002548	9.7	CCL5, CALCA, CCL2, IL6
18	cellular calcium ion homeostasis	GO:006874	9.6	CCL2, CCL5, CD40, TGFB1, ELANE, PTH
19	positive regulation of tyrosine phosphorylation of Stat5 protein	GO:042523	9.6	IL2, IL4, CSF2, KIT
20	positive regulation of chemokine biosynthetic process	GO:045080	9.5	IFNG, IL1B, MYD88, IL4
21	cellular response to organic cyclic compound	GO:071407	9.5	CCL5, CTNNB1, CCL2, IL1B, IL18, TGFB1
22	cell surface receptor signaling pathway	GO:007166	9.4	SST, PTPRC, IFNG, CCL2, CD4, CD28
23	lipopolysaccharide-mediated signaling pathway	GO:031663	9.4	CCL5, CCL2, IL1B, NFKBIA, MYD88, IL18
24	positive regulation of isotype switching to IgG isotypes	GO:048304	9.4	CD40, PTPRC, IFNG, IL4, IL2
25	response to radiation	GO:009314	9.4	BCL2, KIT, IL18, MMP9, TGFB1
26	positive regulation of nitric oxide biosynthetic process	GO:045429	9.3	ICAM1, IL1B, IFNG, PTGS2, TLR4
27	response to gamma radiation	GO:010332	9.3	PTPRC, IL1B, BAX, BCL2, CCL2
28	positive regulation of B cell proliferation	GO:030890	9.3	IL4, BCL2, CD40, IL2, PTPRC, TLR4
29	humoral immune response	GO:006959	9.2	LTF, IFNG, CCL2, BCL2, CD28, IL6
30	cell adhesion	GO:007155	9.2	CXCR3, TGFBI, CCL2, IL2, FN1, ITGAM
31	cell-cell signaling	GO:007267	9.2	CD80, CD86, PTH, SST, CALCA, CCL5
32	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.1	IL1B, CD40, MYD88, UBA52, TGFB1, IL6
33	defense response to virus	GO:051607	9.1	DDX41, PTPRC, IFNG, IL6, CD86, CD40
34	MAPK cascade	GO:000165	9.1	CCL5, TGFB1, IL18, CCL2, MAPK1, IL1B
35	response to ethanol	GO:045471	9.1	MMP9, IL4, STAT3, TLR4, ICAM1, CCL2
36	cellular response to interleukin-1	GO:071347	9.0	ICAM1, CCL5, NFKB1, CCL2, IL8, MMP9
37	innate immune response	GO:045087	8.9	CD4, NFKBIA, MYD88, NFKB1, NLRP1, MAPK1
38	positive regulation of T cell proliferation	GO:042102	8.9	IL1B, IL6, CCL5, IFNG, PTPRC, IL4
39	response to heat	GO:009408	8.9	MMP9, BCL2, CALCA, SST, HSPA4, CCL2
40	cytokine-mediated signaling pathway	GO:019221	8.9	CCL2, STAT3, ICAM1, IFNG, KIT, MYD88
41	cellular response to tumor necrosis factor	GO:071356	8.8	CCL5, ICAM1, CCL2, IL8, IL18
42	angiogenesis	GO:001525	8.8	CCL2, IL8, HSPG2, MMP2, IL18, FN1
43	neutrophil chemotaxis	GO:030593	8.7	SAA1, IL8, CCL2, IL1B, IFNG
44	cellular response to lipopolysaccharide	GO:071222	8.4	ICAM1, TLR4, NOS2, IFNG, CCL2, IL8
45	anti-apoptosis	GO:006916	8.4	NFKBIA, MYD88, BCL2, UBA52, IL1B, CCL2
46	immune response	GO:006955	8.2	IL8, CD4, IL18, MS4A1, IL2RA, CSF2
47	response to hypoxia	GO:001666	8.1	IL1B, IL18, MMP9, BCL2, TGFB1, CCL2
48	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.5	DDX41, STAT3, TGFB1, TLR4, NFKBIA, CTNNB1
49	response to drug	GO:042493	7.5	IL4, ICAM1, IL1RN, SST, IFNG, TGFB1
50	inflammatory response	GO:006954	7.4	LYZ, KIT, TAC1, TGFB1, PTGS2, CALCA

Molecular functions related to gastrointestinal system disease according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	coreceptor activity	GO:015026	10.0	CD80, CD4, CD86, CD28
2	heparin binding	GO:008201	9.7	ELANE, LTF, PTPRC, CCL5, CCL2, FN1
3	protease binding	GO:002020	9.7	ELANE, CD28, BCL2, SELL, KIT
4	enzyme binding	GO:019899	9.1	TGFB1, NFKBIA, NLRP1, CTNNB1, CYP3A4, PTGS2
5	growth factor activity	GO:008083	8.6	TGFB1, IL6, IL4, IL2, IL1B, CSF2
6	cytokine activity	GO:005125	8.2	CSF2, IFNG, IL6, IL4, IL2, IL1B
7	protein homodimerization activity	GO:042803	7.6	TGFB1, TYRP1, NFKB1, NOS2, PTGS2, CCL5
8	protein binding	GO:005515	3.1	GAPDH, NFKB1, NLRP1, NOS2, CTNNB1, SRC