MCID: GST050
MIFTS: 54

Gastrointestinal System Disease malady

Gastrointestinal diseases category

Summaries for Gastrointestinal System Disease

About this section
Sources:
9Disease Ontology, 66Wikipedia, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
Wikipedia:66 The human gastrointestinal tract (GI tract) is an organ system responsible for consuming and digesting... more...

MalaCards: Gastrointestinal System Disease, also known as gastrointestinal diseases, is related to pancreatic cancer and esophageal cancer. An important gene associated with Gastrointestinal System Disease is CD19 (CD19 molecule), and among its related pathways are Nectin adhesion pathway and Thyroid cancer. The drugs sacrosidase and belladonna alkaloids and the compounds d-arginine and saikosaponin have been mentioned in the context of this disorder. Affiliated tissues include the gastrointestinal tract, and related mouse phenotypes are tumorigenesis and renal/urinary system.

Disease Ontology:9 A disease of anatomical entity that is located in the gastrointestinal tract.

Aliases & Classifications for Gastrointestinal System Disease

About this section
Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH, 28ICD9CM, 26ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

gastrointestinal system disease 9 11
gastrointestinal diseases 46 63
digestive system disorders 63
digestive system disorder 9
gastrointestinal disorder 9
alimentary system disease 9
gastrointestinal disease 9
gastroenteropathy 9
git disease 9


External Ids:

Disease Ontology9 DOID:77
NCIt41 C2990
MeSH36 D004066
ICD9CM28 520-579.99
ICD1026 11, K92.2, K92.8

Related Diseases for Gastrointestinal System Disease

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases related to Gastrointestinal System Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 486)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatic cancer29.7PTGS2, JUN, BAX, CDH1, HRAS
2esophageal cancer29.7PTGS2, CDH1
3colon cancer29.6PTGS2, JUN, BAX, CDH1, HRAS
4inflammatory bowel disease29.6PTGS2, ALPI, NOS2
5vascular disease29.6JUN, KNG1, NOS2
6recurrent acute pancreatitis10.4
7cholecystitis10.3
8irritable bowel syndrome10.3
9gastrojejunal ulcer10.3
10gastric ulcer10.3
11eosinophilic gastroenteritis10.2
12galactosemia10.2
13abdominal wall defect10.2
14congenital chloride diarrhea10.2
15chronic diarrhea due to guanylate cyclase 2c overactivity10.2
16perinatal intestinal perforation10.2
17perinatal necrotizing enterocolitis10.2
18pancreas disease10.2
19microvillus inclusion disease10.2
20congenital malabsorptive diarrhea 410.2
21benign recurrent intrahepatic cholestasis10.2
22diarrhea 5, with tufting enteropathy, congenital10.2
23diarrhea 710.2
24meconium ileus10.2
25diarrhea 3, secretory sodium, congenital, syndromic10.2
26congenital enterocyte heparan sulfate deficiency10.2
27epithelio-exfoliative colitis - deafness10.2
28appendicitis10.1
29hepatitis10.1
30protein-losing enteropathy10.1
31gastritis10.1
32dyspepsia10.1
33eating disorder10.1
34congenital diaphragmatic hernia10.1
35leukemia, acute lymphoblastic 310.1CD19, DNTT
36pleurisy10.0KNG1, PTGS2
37angioedema10.0KNG1, PTGS2
38chronic lymphocytic leukemia10.0DNTT, BAX, CD19
39renal fibrosis10.0KNG1, CDH1
40gallbladder cancer10.0BAX, CDH1
41hydrops of gallbladder10.0
42occlusion of gallbladder10.0
43strawberry gallbladder10.0
44perforation of bile duct10.0
45acute orbital inflammation10.0
46biliary tract disease10.0
47cholangitis10.0
48cholestasis10.0
49gallbladder disease10.0
50intestinal disease10.0

Graphical network of the top 20 diseases related to Gastrointestinal System Disease:



Diseases related to gastrointestinal system disease

Symptoms for Gastrointestinal System Disease

About this section

Drugs & Therapeutics for Gastrointestinal System Disease

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Gastrointestinal System Disease

Drug clinical trials:

Search ClinicalTrials for Gastrointestinal System Disease

Search NIH Clinical Center for Gastrointestinal System Disease

Search CenterWatch for Gastrointestinal System Disease

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Gastrointestinal System Disease

About this section

Anatomical Context for Gastrointestinal System Disease

About this section
Sources:
15FMA
See all sources

FMA organs/tissues related to Gastrointestinal System Disease:

15
The gastrointestinal tract

Animal Models for Gastrointestinal System Disease or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Gastrointestinal System Disease:

38 (show all 16)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5PTGS2, NOS2, CD19, CDH1, HRAS
2MP:00053678.5PTGS2, BAX, NOS2, CD19, HRAS
3MP:00053888.3PTGS2, JUN, BAX, NOS2, HRAS
4MP:00053908.1PTGS2, JUN, BAX, NOS2, HRAS
5MP:00028738.1PTGS2, JUN, DNTT, CD19, CDH1, HRAS
6MP:00053798.0PTGS2, JUN, BAX, NOS2, CDH1, HRAS
7MP:00053858.0PTGS2, JUN, NOS2, CD19, CDH1, HRAS
8MP:00053867.9PTGS2, JUN, BAX, NOS2, CD19, HRAS
9MP:00036317.9HRAS, CD19, NOS2, BAX, JUN, PTGS2
10MP:00107717.9PTGS2, CLDN1, JUN, NOS2, CD19, CDH1
11MP:00053977.8PTGS2, JUN, DNTT, BAX, NOS2, CD19
12MP:00053877.5PTGS2, JUN, DNTT, BAX, NOS2, CD19
13MP:00053847.5PTGS2, JUN, BAX, NOS2, CD19, CDH1
14MP:00053787.5PTGS2, CLDN1, JUN, BAX, NOS2, CD19
15MP:00107687.4PTGS2, CLDN1, JUN, BAX, NOS2, CD19
16MP:00053767.1HRAS, PTGS2, CLDN1, JUN, BAX, KNG1

Publications for Gastrointestinal System Disease

About this section

Variations for Gastrointestinal System Disease

About this section

Expression for genes affiliated with Gastrointestinal System Disease

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Gastrointestinal System Disease

Search GEO for disease gene expression data for Gastrointestinal System Disease.

Pathways for genes affiliated with Gastrointestinal System Disease

About this section
Sources:
51PathCards, 39NCBI BioSystems Database, 31KEGG, 54QIAGEN, 61Thomson Reuters, 56Reactome, 55R&D Systems, 62Tocris Bioscience, 52PharmGKB
See all sources

Pathways related to Gastrointestinal System Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CDH1, CLDN1
29.7CDH1, HRAS
39.7HRAS, CDH1
49.7HRAS, JUN
59.7HRAS, JUN
6
Show member pathways
AhR pathway39
9.6JUN, BAX
79.6BAX, JUN
89.4HRAS, KNG1, BAX
9
Show member pathways
9.4JUN, CD19, HRAS
10
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
9.4HRAS, CD19, JUN
11
Show member pathways
9.4HRAS, CD19, JUN
12
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility61
Cytoskeleton remodeling Integrin outside in signaling61
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases61
Cell adhesion Tight junctions61
Development MAG dependent inhibition of neurite outgrowth61
9.4CLDN1, JUN, HRAS
139.4JUN, BAX, CD19
14
Show member pathways
IL-9 Signaling Pathway39
Development Thrombopoietin regulated cell processes61
IL-7 Signaling Pathway39
Immune response IL 9 signaling pathway61
9.3JUN, BAX, HRAS
15
Show member pathways
9.3JUN, BAX, HRAS
16
Show member pathways
9.3JUN, BAX, HRAS
17
Show member pathways
Prostate Cancer39
Integrated Cancer pathway39
Steroid Biosynthesis39
9.3JUN, BAX, HRAS
189.3JUN, BAX, HRAS
19
Show member pathways
Apoptosis and survival BAD phosphorylation61
Development Alpha 2 adrenergic receptor activation of ERK61
Chemotaxis CXCR4 signaling pathway61
9.3JUN, BAX, HRAS
20
Show member pathways
9.3HRAS, BAX, JUN
219.3HRAS, BAX, JUN
22
Show member pathways
9.3HRAS, BAX, JUN
23
Show member pathways
Development ERBB family signaling61
Development GDNF family signaling61
9.3HRAS, CDH1, JUN
249.3HRAS, CDH1, JUN
25
Show member pathways
RAC1 signaling pathway39
9.3HRAS, CDH1, JUN
269.3JUN, CDH1, HRAS
279.2CDH1, BAX, JUN
28
Show member pathways
9.1HRAS, JUN, PTGS2
29
Show member pathways
9.1HRAS, JUN, PTGS2
309.1PTGS2, BAX, CDH1
31
Show member pathways
9.0HRAS, CD19, BAX, JUN
329.0BAX, JUN, PTGS2
33
Show member pathways
9.0HRAS, CDH1, JUN, CLDN1
34
Show member pathways
8.9JUN, BAX, CDH1, HRAS
35
Show member pathways
8.9JUN, BAX, CDH1, HRAS
36
Show member pathways
Signal transduction PTEN pathway61
8.9JUN, BAX, CDH1, HRAS
37
Show member pathways
8.9NOS2, JUN, PTGS2
388.9NOS2, JUN, PTGS2
39
Show member pathways
Immune response MIF in innate immunity response61
8.9NOS2, JUN, PTGS2
408.9PTGS2, JUN, NOS2
41
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
8.8JUN, BAX, NOS2, HRAS
42
Show member pathways
Prolactin Signaling Pathway39
Development Prolactin receptor signaling61
Leptin signaling pathway39
8.8JUN, BAX, NOS2, HRAS
43
Show member pathways
8.8PTGS2, JUN, CD19, HRAS
44
Show member pathways
Immune response BCR pathway61
Fc-epsilon receptor I signaling in mast cells39
8.8PTGS2, JUN, CD19, HRAS
45
Show member pathways
8.7PTGS2, JUN, BAX, HRAS
46
Show member pathways
Development EGFR signaling via PIP361
Development PDGF signaling via MAPK cascades61
Apoptosis and survival Anti apoptotic action of membrane bound ESR161
Signaling of Hepatocyte Growth Factor Receptor39
Development EGFR signaling via small GTPases61
Development Neurotrophin family signaling61
Apoptosis and survival NGF signaling pathway61
Apoptosis and survival Role of CDK5 in neuronal death and survival61
8.7PTGS2, JUN, BAX, HRAS
478.7CDH1, JUN, CLDN1, PTGS2
48
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways61
Immune response IL 1 signaling pathway61
8.6HRAS, NOS2, JUN, PTGS2
49
Show member pathways
8.3PTGS2, JUN, BAX, CDH1, HRAS
507.8HRAS, CDH1, NOS2, BAX, JUN, PTGS2

Compounds for genes affiliated with Gastrointestinal System Disease

About this section
Sources:
46Novoseek, 25HMDB, 12DrugBank, 52PharmGKB, 62Tocris Bioscience, 30IUPHAR, 3BitterDB
See all sources

Compounds related to Gastrointestinal System Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 114)
idCompoundScoreTop Affiliating Genes
1d-arginine46 25 1211.8NOS2, KNG1
2saikosaponin469.8BAX, JUN
3ketorolac46 1210.6PTGS2, NOS2
4exisulind469.5CDH1, PTGS2, BAX
5sulindac sulfide469.4BAX, PTGS2, JUN
6vinblastine46 52 1211.4CDH1, BAX, JUN
7c2ceramide469.4BAX, NOS2, JUN
8cyclopentenone469.3PTGS2, JUN, NOS2
9silymarin469.2NOS2, JUN, PTGS2
10sulindac46 1210.2PTGS2, BAX, HRAS, CDH1
11gf 109203x46 6210.1PTGS2, HRAS, KNG1, JUN
1215-deoxy-delta-12,14-prostaglandin j2469.1JUN, NOS2, PTGS2
13mg 13246 6210.1JUN, BAX, NOS2, CDH1
1412-o-tetradecanoylphorbol 13-acetate469.0HRAS, CDH1, DNTT, JUN
154-hydroxynonenal46 2510.0NOS2, BAX, JUN
16troglitazone46 30 62 1212.0BAX, JUN, PTGS2, CDH1
17celecoxib46 62 30 52 25 1214.0BAX, PTGS2, CDH1, NOS2
18doxorubicin46 52 1211.0CD19, BAX, NOS2, CDH1, HRAS
19quercetin46 62 25 1211.9DNTT, NOS2, BAX, JUN
20pdtc468.9JUN, NOS2, PTGS2
21triptolide468.9BAX, JUN, NOS2, PTGS2
22ciglitazone46 309.9NOS2, PTGS2, BAX, JUN
23sulforaphane468.9NOS2, BAX, JUN, PTGS2
24wortmannin468.9BAX, HRAS, CDH1, JUN
25resveratrol46 62 25 1211.9BAX, PTGS2, JUN, NOS2
26indomethacin46 30 62 1211.9NOS2, KNG1, PTGS2, CDH1
27paraffin468.8HRAS, BAX, DNTT, CDH1
28irinotecan46 52 1210.8CDH1, PTGS2, BAX
29pd 98,059468.7HRAS, CDH1, PTGS2, JUN, BAX
30adenylate468.7HRAS, CDH1, NOS2, DNTT, KNG1
31arachidonic acid46 30 25 1211.6KNG1, DNTT, PTGS2, HRAS, CDH1
32herbimycin a46 629.6NOS2, JUN, CDH1, HRAS, PTGS2
33cisplatin46 52 62 1211.6HRAS, CDH1, BAX, PTGS2, DNTT
34actinomycin d468.5PTGS2, JUN, BAX, KNG1, NOS2
35egcg468.5NOS2, BAX, CDH1, JUN, PTGS2
36curcumin468.5JUN, BAX, NOS2, CDH1, PTGS2
37etoposide46 52 62 1211.5CDH1, BAX, PTGS2, DNTT, JUN
38n acetylcysteine468.5BAX, PTGS2, NOS2, CDH1, JUN
39sb 20358046 629.5CDH1, NOS2, BAX, JUN, PTGS2
40cycloheximide468.5BAX, JUN, KNG1, PTGS2, NOS2
41nitric oxide46 25 1210.3HRAS, NOS2, KNG1, PTGS2, DNTT
42butyrate468.3JUN, DNTT, ALPI, BAX, CDH1
43ly294002468.2CDH1, BAX, NOS2, JUN, PTGS2, HRAS
44dexamethasone46 52 30 1211.2PTGS2, NOS2, CDH1, DNTT, JUN
45vegf468.2CDH1, PTGS2, JUN, BAX, NOS2, HRAS
46estrogen468.1BAX, NOS2, HRAS, JUN, PTGS2, CDH1
47phosphatidylinositol467.9HRAS, ALPI, BAX, CDH1, KNG1, JUN
48genistein46 30 62 3 25 1212.9HRAS, CDH1, NOS2, PTGS2, JUN, BAX
49calcium46 52 25 1210.8HRAS, CLDN1, ALPI, KNG1, NOS2, CD19
50pge2467.7JUN, DNTT, KNG1, NOS2, CDH1, HRAS

GO Terms for genes affiliated with Gastrointestinal System Disease

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Gastrointestinal System Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lateral plasma membraneGO:0163289.8CDH1, CLDN1

Biological processes related to Gastrointestinal System Disease according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of DNA replicationGO:0457409.8HRAS, JUN
2release of cytochrome c from mitochondriaGO:0018369.8JUN, BAX
3cellular response to UVGO:0346449.7BAX, PTGS2
4Fc-epsilon receptor signaling pathwayGO:0380959.6HRAS, CD19, JUN
5negative regulation of neuron apoptotic processGO:0435249.6HRAS, BAX, JUN
6positive regulation of neuron apoptotic processGO:0435259.5BAX, JUN
7learningGO:0076129.4JUN, PTGS2
8positive regulation of apoptotic processGO:0430659.2PTGS2, BAX, KNG1
9positive regulation of smooth muscle cell proliferationGO:0486619.1JUN, PTGS2
10response to drugGO:0424939.1CDH1, JUN, PTGS2
11inflammatory responseGO:0069549.0PTGS2, KNG1, NOS2

Products for genes affiliated with Gastrointestinal System Disease

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gastrointestinal System Disease

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet