MCID: GST050
MIFTS: 53

Gastrointestinal System Disease

Categories: Gastrointestinal diseases

Aliases & Classifications for Gastrointestinal System Disease

MalaCards integrated aliases for Gastrointestinal System Disease:

Name: Gastrointestinal System Disease 12 14
Gastrointestinal Diseases 52 69
Digestive System Disorders 69
Alimentary System Disease 12
Digestive System Disorder 12
Gastrointestinal Disorder 12
Digestive System Diseases 42
Gastrointestinal Disease 12
Gastroenteropathy 12
Git Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:77
ICD9CM 35 520-579.99
MeSH 42 D004066
UMLS 69 C0012242

Summaries for Gastrointestinal System Disease

Disease Ontology : 12 A disease of anatomical entity that is located in the gastrointestinal tract.

MalaCards based summary : Gastrointestinal System Disease, also known as gastrointestinal diseases, is related to gastric ulcer and eosinophilic gastroenteritis, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Gastrointestinal System Disease is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Peptide ligand-binding receptors and IL-17 Family Signaling Pathways. The drugs Metronidazole and Acetylcysteine have been mentioned in the context of this disorder. Affiliated tissues include liver, colon and testes, and related phenotypes are digestive/alimentary and homeostasis/metabolism

Wikipedia : 72 Gastrointestinal diseases refer to diseases involving the gastrointestinal tract, namely the esophagus,... more...

Related Diseases for Gastrointestinal System Disease

Diseases related to Gastrointestinal System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 206)
id Related Disease Score Top Affiliating Genes
1 gastric ulcer 31.6 ALB TLR9 TNF
2 eosinophilic gastroenteritis 31.2 AREG GAST GHRL IL1B S100A8
3 tricuspid valve stenosis 11.2 ATP4A CCK SCT
4 cryptogenic organizing pneumonia 11.2 ALB ATP4A TRPV1
5 congenital dyserythropoietic anemia 11.1 ALB TNF
6 eyelid neoplasm 11.1 CCL11 TLR9 TRPV1
7 fecal incontinence 11.1 CCK CCKAR SCT
8 tamoxifen-related endometrial lesion 11.1 CCK GAST SCT
9 scrotal carcinoma 11.1 ATP4A IL1B TNF
10 scrotum melanoma 11.1 ATP12A ATP4A
11 tinea favosa 11.1 IL1B TNF TRPV1
12 perianal hematoma 11.1 CCK GAST MLN
13 epulis 11.1 IL1B TNF TRPV1
14 primary syphilis 11.1 ATP12A ATP4A GAST
15 bone giant cell sarcoma 11.1 ATP12A ATP4A GAST
16 central nervous system leiomyosarcoma 11.1 IL1B TLR9 TNF
17 benign familial infantile epilepsy 11.1 ATP4A IL1B TRPV1
18 mandibular cancer 11.1 CCK CCKAR GHRL TRPV1
19 cataract 11.1 ALB IL1B TNF
20 ovary transitional cell carcinoma 11.1 ALB GAST
21 congenital aphakia 11.1 ATP12A ATP4A
22 acquired thrombocytopenia 11.1 IL1B TNF TRPV1
23 dehydration polycythemia 11.1 CCL11 TLR9 TNF TRPV1
24 fungal gastritis 11.1 ATP12A ATP4A CCL11
25 pelvic varices 11.1 CCL11 TLR9 TNF TRPV1
26 polysyndactyly with cardiac malformation 11.1 ALB ATP12A ATP4A
27 muscle cancer 11.1 ATP12A ATP4A GAST
28 testicular infarct 11.1 IL1B TLR9 TNF
29 myeloid sarcoma 11.1 IL1B TLR9 TNF
30 ostertagiasis 11.1 IL1B TLR9 TNF
31 peripheral degeneration of cornea 11.1 GCG PYY SCT
32 breast disease 11.1 IL1B TLR9 TNF
33 dentin caries 11.1 ALB CCL11 TLR9
34 mesenteric vascular occlusion 11.1 ATP12A ATP4A PYY
35 shwartzman phenomenon 11.1 ATP12A ATP4A
36 arthus reaction 11.1 ALB IL1B TNF
37 chondroma 11.1 CCK GCG SCT TRPV1
38 benign mammary dysplasia 11.1 ALB CCL11 TLR9 TNF
39 urethral calculus 11.1 ATP12A ATP4A
40 mesenchymal cell neoplasm 11.1 IL1B TLR9 TNF TRPV1
41 fuchs' heterochromic uveitis 11.1 CCL11 TLR9 TNF
42 bacterial gastritis 11.1 IL1B TLR9 TNF TRPV1
43 perinatal necrotizing enterocolitis 11.1 ALB CCK GHRL PYY
44 breast ductal adenoma 11.1 ATP12A ATP4A
45 dermatomyositis 11.1 ALB CCK CCKAR
46 calcinosis 11.1 ALB TLR9 TNF TRPV1
47 tropical sprue 11.1 CCK GCG PYY
48 mikulicz disease 11.1 ALB IL1B TLR9 TNF
49 legionellosis 11.1 IL1B TLR9 TNF
50 hypopituitarism 11.1 ATP12A ATP4A

Graphical network of the top 20 diseases related to Gastrointestinal System Disease:



Diseases related to Gastrointestinal System Disease

Symptoms & Phenotypes for Gastrointestinal System Disease

UMLS symptoms related to Gastrointestinal System Disease:


abdominal pain, constipation, diarrhea, dyspepsia, halitosis, heartburn, icterus, nausea and vomiting, oral manifestations, pathological conditions, signs and symptoms, signs and symptoms of ill-defined conditions, digestive system symptom, gastrointestinal gas, abdomen, acute, abdominal cramps, eructation, flatulence, flatulence, eructation, and gas pain, glossalgia, nausea, rectal pain, signs and symptoms, digestive, vomiting, tongue discoloration, liver tender, symptoms involving digestive system, other symptoms involving digestive system, odynophagia, abdominal discomfort, upper abdominal pain, lower abdominal pain, retching, rectal tenesmus, dry throat, hyperemesis, abdominal distress, epigastric pain not food-related, right upper quadrant pain, epigastric food-related pain, upset stomach, abdominal fullness, salivary gland pain, abdominal distention, gaseous, edema of mouth, anal pain, burning tongue, infantile colic, vomiting in newborn, change in bowel habits, stomach cramps (finding), gastric irritation, swallowing problems, gastrointestinal symptoms, sore lip, gastrointestinal pain, vomiting alone, abdominal distress/pain as reason for lower g.i. examination, abdominal distress/pain as reason for upper g.i. examination, anal discomfort, abdominal bloating, epigastric discomfort, blood in stool, catarrh, peeling tongue

MGI Mouse Phenotypes related to Gastrointestinal System Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.61 ALB AREG ATP12A ATP4A CCKAR GAST
2 homeostasis/metabolism MP:0005376 9.47 HTR4 IL1B PYY TLR9 TNF TRPV1

Drugs & Therapeutics for Gastrointestinal System Disease

Drugs for Gastrointestinal System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1444)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metronidazole Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 443-48-1 4173
2
Acetylcysteine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 616-91-1 12035
3
Cisplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
4
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-78-2 2244
5
Benzocaine Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 1994-09-7, 94-09-7 2337
6
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 26787-78-0 33613 2171
7
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 85721-33-1 2764
8
Amlodipine Approved Phase 4,Phase 1,Phase 2 88150-42-9 2162
9
Perindopril Approved Phase 4 107133-36-8, 82834-16-0 107807
10
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
11
Pancrelipase Approved Phase 4,Phase 2,Phase 3,Phase 1 53608-75-6
12
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 104987-11-3 445643 439492
13
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 57-27-2 5288826
14
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 73590-58-6 4594
15
Rabeprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 117976-89-3 5029
16
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 51-43-4 5816
17 Racepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1
18
Caspofungin Approved Phase 4 179463-17-3, 162808-62-0 468682 2826718
19
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
20
Esomeprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 161796-78-7, 119141-88-7 4594 9579578
21
Ezetimibe Approved Phase 4,Phase 2 163222-33-1 150311
22
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1 103-90-2 1983
23
Clonidine Approved Phase 4,Phase 3,Phase 2,Phase 1 4205-90-7 2803
24
Ropivacaine Approved Phase 4,Phase 3,Phase 2,Phase 1 84057-95-4 71273 175805
25
Sufentanil Approved, Investigational Phase 4,Phase 2 56030-54-7 41693
26
Tramadol Approved, Investigational Phase 4,Phase 2,Phase 3 27203-92-5 33741
27
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 437-38-7 3345
28
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 128794-94-5 5281078
29
Mycophenolic acid Approved Phase 4,Phase 3,Phase 1,Phase 2 24280-93-1 446541
30
Propranolol Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 525-66-6 4946
31
Nadolol Approved Phase 4,Phase 3 42200-33-9 39147
32
Cefoperazone Approved Phase 4 62893-19-0 44185
33
Chlorhexidine Approved, Vet_approved Phase 4,Phase 2 55-56-1 9552079 2713
34
Meropenem Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 119478-56-7 64778 441130
35
Somatostatin Approved Phase 4,Phase 3,Phase 2,Phase 1 38916-34-6, 51110-01-1 53481605
36
Clarithromycin Approved Phase 4,Phase 3,Phase 2 81103-11-9 84029
37
Clofazimine Approved, Investigational Phase 4,Phase 3 2030-63-9 2794
38
Rifabutin Approved Phase 4,Phase 3 72559-06-9 6323490
39
Rifaximin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 80621-81-4 6436173
40
Adefovir Dipivoxil Approved, Investigational Phase 4,Phase 1,Phase 2 142340-99-6 60871
41
Telbivudine Approved, Investigational Phase 4,Phase 2 3424-98-4 159269
42
Spironolactone Approved Phase 4,Phase 2,Phase 3 1952-01-7, 52-01-7 5833
43
Magnesium oxide Approved Phase 4,Phase 1 1309-48-4 14792
44
Lamivudine Approved, Investigational Phase 4,Phase 1,Phase 2 134678-17-4 60825
45
Ketamine Approved, Vet_approved Phase 4,Phase 2,Phase 3 6740-88-1 3821
46
Remifentanil Approved Phase 4,Phase 2 132875-61-7 60815
47
Carvedilol Approved, Investigational Phase 4,Phase 3 72956-09-3 2585
48
Ursodeoxycholic acid Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 128-13-2 31401
49
Adalimumab Approved Phase 4,Phase 3,Phase 2,Phase 1 331731-18-1 16219006
50
Infliximab Approved Phase 4,Phase 2,Phase 3,Phase 1 170277-31-3

Interventional clinical trials:

(show top 50) (show all 10000)

id Name Status NCT ID Phase Drugs
1 The Treatment of Periodontal Diseases Unknown status NCT01318928 Phase 4 Metronidazol
2 Prophylactic Pancreatic Duct Stent Placement After ESP of Major Papillary Tumors; Prospective, Randomized Study Unknown status NCT01737463 Phase 4
3 THE USE OF N-ACETYLCYSTEINE ATTENUATING CISPLATIN-INDUCED TOXICITIES BY OXIDATIVE STRESS Unknown status NCT02241876 Phase 4 N-acetylcysteine
4 Prospective Random Comparing Study on EUS-guided Pseudocyst Drainage by Naso-pancreatic Tube and Stents Unknown status NCT01585662 Phase 4
5 The Risk of Bleeding After Removal of Large Colorectal Polyps in Patients Taking Aspirin Unknown status NCT01549418 Phase 4 Aspirin (ASA);Placebo
6 The Effect of Vitamin D3 to Maintain Surgical Remission in Postoperative Crohn's Disease Unknown status NCT02010762 Phase 4 Vitamin D;Placebo
7 Diverticulitis: Antibiotics or Close Observation? Unknown status NCT01111253 Phase 4 Amoxicillin-clavulanate
8 The Orange-III Trial: Optimised Recovery With Movicol® Preoperatively Within an Enhanced Recovery Programme Unknown status NCT01429779 Phase 4 Movicol
9 Placebo Controlled Study Using Lovaza as Treatment for Non-Alcoholic Fatty Liver Disease Unknown status NCT00941642 Phase 4 Lovaza;placebo control
10 Perindopril and Telmisartan for the Treatment of Nonalcoholic Fatty Liver Disease Unknown status NCT02213224 Phase 4 Perindopril;Telmisartan;Amlodipine
11 Double- Versus Single-balloon Enteroscopy for Obscure Small-bowel Bleeding Unknown status NCT01176864 Phase 4
12 The Effect Of Dual Treatment With L-Carnitine And Magnesium On Fatty Liver Unknown status NCT01956825 Phase 4
13 Effect of an Artificial Pancreas in Patients Undergoing Pancreatic Resection Unknown status NCT00661648 Phase 4
14 A Study of Thymoglobulin and Tacrolimus in Liver Transplant Unknown status NCT00564538 Phase 4 anti-thymocyte globulin (rabbit);tacrolimus
15 Intravenous-Morphine and Glucagon-Usage Enhanced MR Cholangiography Unknown status NCT00155376 Phase 4 morphine and glucagon
16 The Impact of Rockall Risk Scoring System on Management of Upper Gastrointestinal System Bleeding Unknown status NCT01269814 Phase 4
17 Comparison of Oral Rabeprazole vs. iv Omeprazole in Mild to Moderate Nonvariceal Upper Gastrointestinal Bleeding Unknown status NCT00861640 Phase 4 Intravenous Omeprazole;Oral Rabeprazole
18 Trial of Hemospray Plus Epinephrine Injection Versus Endoscopic Hemoclip Unknown status NCT02537353 Phase 4 Hemospray;Adrenaline
19 Single-Operator Versus Dual-Operator Double-balloon Endoscopy in Patients With Small-Bowel Disorders Unknown status NCT01184690 Phase 4
20 Pharmacokinetics of Caspofungin After One Dose in Patients With Liver Failure Unknown status NCT01968395 Phase 4 Caspofungin 70 mg
21 A Double Blind Study Comparing Two Doses of IV Esomeprazole After Successful Endoscopic Therapy Unknown status NCT01275937 Phase 4 Esomeprazole;esomeprazole
22 SILS™ Port Laparoscopic Cholecystectomy Post Market Study Unknown status NCT00832767 Phase 4
23 Lifestyle Versus Ezetimibe Plus Lifestyle in Patients With Non-alcoholic Steatohepatitis Unknown status NCT01950884 Phase 4 Ezetimibe
24 Epidural Analgesia for Pancreatitis (Epipan Study) Unknown status NCT02126332 Phase 4
25 Outcome Study of Double Bare Stent for Malignant Gastric Outlet Obstruction Unknown status NCT02156505 Phase 4
26 Analgesic Efficacy of Intravenous Hyoscine-N-Butylbromide (HNB) in Abdominal Colic Associated With Acute Gastroenteritis Unknown status NCT02508142 Phase 4 Hyoscine-N-Butylbromide
27 TO Compare the Triple Drug Therapy and Dual Therapy . Unknown status NCT02075242 Phase 4 Mycophenolate Mofetil;Tacrolimus
28 A Trial of EVL\GVS Alone vs. EVL\GVS Combined Propranolol Unknown status NCT01298284 Phase 4 propranolol
29 Endoscopic Cyanoacrylate Obliteration vs. Nadolol Treatment in the Prevention of Gastric Variceal Rebleeding Unknown status NCT00567216 Phase 4 Nadolol
30 Multi-center Clinical Study of Early Antibios of Severe Acute Pancreatitis Unknown status NCT01992198 Phase 4 cefoperazone + metronidazole;Somatostatin;Meropenem
31 Comparative Study About the Impact of Two Oil Emulsions Administered Intravenously on Severe Acute Pancreatitis Unknown status NCT01376817 Phase 4 Fat emulsion with MCT, LCT, olive oil and omega 3 fatty acids;Fat emulsion with MCT and LCT
32 Evaluation of PET CT in the Management of Patients With Crohn's Disease. Unknown status NCT00731809 Phase 4
33 VSL#3 Treatment in Children With Crohn's Disease Unknown status NCT00367705 Phase 4
34 Effect of Probiotics on Gut-Liver Axis of Alcoholic Hepatitis Unknown status NCT02335632 Phase 4 Probiotics (Lacidofil®);Placebo
35 Treatment of Crohn's Disease With an Antibiotic Regimen Directed Against Mycobacterium Avium Paratuberculosis Unknown status NCT00513552 Phase 4 Rifabutin, Clarithromycin, and Clofazimine
36 Confocal Endomicroscopy During Endoscopy Unknown status NCT00988273 Phase 4
37 Rifaximin Predicts the Complications of Decompensated Cirrhosis Unknown status NCT02074280 Phase 4 rifaximin
38 Telbivudine Renoprotective Effect in Patients With the HBV-related Liver Cirrhosis: a Randomized Controlled Trial Unknown status NCT01799486 Phase 4 Telbivudine;Enecavir;Adefovir
39 Effect of Betablocker or Aldosterone Antagonist Therapy on Patients With Liver Cirrhosis Unknown status NCT00332904 Phase 4 propranolol;spironolactone
40 Magnesium in Liver Cirrhosis Unknown status NCT01894867 Phase 4
41 Withholding Feeds During Red Blood Cell Transfusion and TRAGI Unknown status NCT02132819 Phase 4
42 Telbivudine Renoprotective Effect in Patients With HBV-related Liver Cirrhosis Unknown status NCT01693679 Phase 4 Telbivudine, Lamivudine, Adefovir ,Enecavir
43 Development of an Imaging Biomarker for Hepatic Fibrosis Using Gadoxetate Disodium Unknown status NCT01783314 Phase 4
44 LGG for Prevention of Infectious Complications During PPI Treatment in Children Unknown status NCT01782118 Phase 4
45 Effect of Intraoperative Nefopam on Acute Pain After Remifentanil Based Anesthesia Unknown status NCT02493231 Phase 4 Nefopam;Ketamine;Saline
46 Efficacy and Safety of Floseal for the Haemostasis During Laparoscopic Cholecystectomy in Acute Cholecystitis (GLA) Unknown status NCT01126281 Phase 4
47 RCT of Carvedilol Versus Variceal Band Ligation in the Primary Prophylaxis of Oesophageal Variceal Haemorrhage Unknown status NCT01070641 Phase 4 Carvedilol
48 Echocardiographic Assessment of Intrapulmonary Vasodilatation: Agitated Saline Versus Polygeline Unknown status NCT00343122 Phase 4
49 Efficacy and Safety of Ursodeoxycholic Acid (UDCA) Added to the DPP-4 Inhibitor in People With Type 2 Diabetes and Chronic Liver Diseases Unknown status NCT01337440 Phase 4 UDCA;Sitagliptin
50 Use of Combined Measurements of Serum Infliximab and Anti-infliximab Antibodies in the Treatment of Patients With Crohns Disease Failing Infliximab Therapy Unknown status NCT00851565 Phase 4

Search NIH Clinical Center for Gastrointestinal System Disease

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: digestive system diseases

Genetic Tests for Gastrointestinal System Disease

Anatomical Context for Gastrointestinal System Disease

MalaCards organs/tissues related to Gastrointestinal System Disease:

39
Liver, Colon, Testes, Bone, Lung, Pancreas, T Cells

Publications for Gastrointestinal System Disease

Variations for Gastrointestinal System Disease

Expression for Gastrointestinal System Disease

Search GEO for disease gene expression data for Gastrointestinal System Disease.

Pathways for Gastrointestinal System Disease

Pathways related to Gastrointestinal System Disease according to GeneCards Suite gene sharing:

(show all 11)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.24 CCK CCKAR GCG GHRL HTR4 MLN
2
Show member pathways
12.11 CCL11 IL1B S100A8 TNF
3
Show member pathways
11.92 CCL11 IL1B TLR9 TNF
4 11.55 IL1B TLR9 TNF
5 11.48 MADCAM1 TLR9 TNF
6 11.41 CCL11 IL1B TNF
7 11.23 IL1B TLR9 TNF
8 10.88 IL1B TLR9 TNF
9 10.64 AREG IL1B TNF
10 9.96 ATP4A GAST
11 9.64 CCK GAST SCT

GO Terms for Gastrointestinal System Disease

Cellular components related to Gastrointestinal System Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 ALB CCK CCL11 GAST GCG GHRL
2 extracellular space GO:0005615 9.47 ALB AREG ATP4A CCK CCL11 GAST

Biological processes related to Gastrointestinal System Disease according to GeneCards Suite gene sharing:

(show all 26)
id Name GO ID Score Top Affiliating Genes
1 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.78 CCK S100A8 TNF
2 positive regulation of JNK cascade GO:0046330 9.75 IL1B TLR9 TNF
3 regulation of insulin secretion GO:0050796 9.74 GCG IL1B TNF
4 neutrophil chemotaxis GO:0030593 9.72 CCL11 IL1B S100A8
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.71 IL1B S100A8 TLR9 TNF
6 positive regulation of interleukin-6 production GO:0032755 9.69 IL1B TLR9 TNF
7 leukocyte tethering or rolling GO:0050901 9.63 MADCAM1 TNF
8 feeding behavior GO:0007631 9.63 CCKAR GCG PYY
9 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.62 IL1B TNF
10 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.62 ATP12A ATP4A
11 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.61 IL1B TNF
12 positive regulation of nitric oxide biosynthetic process GO:0045429 9.61 IL1B TNF TRPV1
13 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.6 IL1B TLR9
14 positive regulation of chemokine biosynthetic process GO:0045080 9.59 IL1B TNF
15 regulation of appetite GO:0032098 9.58 HTR4 PYY
16 chronic inflammatory response GO:0002544 9.56 CCL11 S100A8
17 regulation of establishment of endothelial barrier GO:1903140 9.52 IL1B TNF
18 fever generation GO:0001660 9.49 IL1B TRPV1
19 positive regulation of fever generation GO:0031622 9.48 IL1B TNF
20 positive regulation of interleukin-8 production GO:0032757 9.43 IL1B TLR9 TNF
21 inflammatory response GO:0006954 9.43 CCL11 IL1B S100A8 TLR9 TNF TRPV1
22 sequestering of triglyceride GO:0030730 9.37 IL1B TNF
23 positive regulation of NF-kappaB import into nucleus GO:0042346 9.33 IL1B TLR9 TNF
24 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.32 IL1B TNF
25 G-protein coupled receptor signaling pathway GO:0007186 9.28 AREG CCKAR CCL11 GAST GCG GHRL
26 signal transduction GO:0007165 10.19 CCK CCKAR CCL11 GAST GCG HTR4

Molecular functions related to Gastrointestinal System Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.46 AREG CCL11 IL1B TNF
2 sodium:potassium-exchanging ATPase activity GO:0005391 9.26 ATP12A ATP4A
3 hormone activity GO:0005179 9.17 CCK GAST GCG GHRL MLN PYY
4 hydrogen:potassium-exchanging ATPase activity GO:0008900 8.96 ATP12A ATP4A

Sources for Gastrointestinal System Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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