MCID: GST050
MIFTS: 50

Gastrointestinal System Disease malady

Gastrointestinal category

Summaries for Gastrointestinal System Disease

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Wikipedia:64 The human gastrointestinal tract is the stomach and intestine, sometimes including all the structures... more...

MalaCards: Gastrointestinal System Disease, also known as gastrointestinal diseases, is related to irritable bowel syndrome and eosinophilic gastroenteritis. An important gene associated with Gastrointestinal System Disease is CD19 (CD19 molecule), and among its related pathways are IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation and Hematopoietic cell lineage. The drugs prednisolone and prednisone and the compounds flagellin and belatacept have been mentioned in the context of this disorder. Affiliated tissues include the gastrointestinal tract, and related mouse phenotypes are renal/urinary system and immune system.

Disease Ontology:8 A disease of anatomical entity that is located in the gastrointestinal tract.

Aliases & Classifications for Gastrointestinal System Disease

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH, 27ICD9CM, 57SNOMED-CT, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal


Aliases & Descriptions:

gastrointestinal system disease 8 10
gastrointestinal diseases 45 61
digestive system disorders 61
alimentary system disease 8
gastrointestinal disorder 8
digestive system disorder 8
gastrointestinal disease 8
gastroenteropathy 8
git disease 8


External Ids:

Disease Ontology8 DOID:77
MeSH35 D004066
ICD9CM27 520-579.99
NCIt40 C2990
ICD1025 11, K92.2, K92.8

Related Diseases for Gastrointestinal System Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Gastrointestinal System Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 127)
idRelated DiseaseScoreTop Affiliating Genes
1irritable bowel syndrome10.3
2eosinophilic gastroenteritis10.2
3protein-losing enteropathy10.1
4eosinophilic enteropathy10.1
5dyspepsia10.1
6systemic mastocytosis10.1
7mastocytosis10.1
8superior mesenteric artery syndrome10.1
9pain disorder10.0
10celiac disease10.0
11cyclic vomiting syndrome10.0
12alagille syndrome10.0
13cystic fibrosis10.0
14giardiasis10.0
15hermansky-pudlak syndrome10.0
16crohn's disease10.0LYZ
17nephritis10.0CXCR3
18psoriasis10.0NPS, CXCR3, TAC1
19lupus nephritis10.0CXCR3, DNTT
20hepatitis c10.0CXCR3, CD86
21lymphoma, malt, somatic10.0CD80, CXCR3
22multiple myeloma10.0CD19
23dermatitis10.0NPS, CXCR3, TAC1
24complex regional pain syndrome10.0NPS, TAC1
25hepatitis b10.0MYD88, CD86, CD80
26tetanus10.0CD80, CD86
27herpes simplex10.0CD80, DNTT
28sarcoma10.0LYZ
29cork-handlers' disease10.0LYZ, RRM2, CD19
30atherosclerosis10.0CXCR3, MYD88, SAA1
31skin disease10.0LYZ
32myeloma10.0DNTT, CD19, CD86, CD80
33autoimmune thyroiditis10.0TYRP1, CD80, CXCR3
34cholera10.0TYRP1, TAC1, PTH
35b-cell lymphomas10.0MS4A1, CXCR3, CD80, CD19
36sarcoidosis10.0CD86, CD80, CXCR3, TAC1, LYZ
37diabetes mellitus10.0PTH, RRM2, TAC1, NPS
38chronic lymphocytic leukemia10.0DNTT, CD19, CD86, CD80, CXCR3, MS4A1
39non-hodgkin lymphoma10.0DNTT, CD19, CD86, CD80, MS4A1
40colorectal cancer10.0CD80, CD86
41acute leukemia10.0CD80, DNTT
42arthritis10.0SAA1, NPS, CD86, CD80, CXCR3, TAC1
43hypertension10.0PTH, RRM2, TAC1
44influenza10.0CXCR3, CD80, CD86, MYD88
45meningitis10.0LYZ
46acute lymphocytic leukemia10.0DNTT, CD19, CXCR3, TAC1
47leukemia10.0DNTT, CD19, CD86, CD80, CXCR3, LYZ
48sjogren's syndrome10.0CXCR3, CD80, CD86
49ulcerative colitis10.0TAC1, CXCR3, CD80, CD86
50inflammatory bowel disease10.0CD86, CD80, TAC1, ALPI

Graphical network of the top 20 diseases related to Gastrointestinal System Disease:



Diseases related to gastrointestinal system disease

Clinical Features for Gastrointestinal System Disease

Drugs & Therapeutics for Gastrointestinal System Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Gastrointestinal System Disease

Drug clinical trials:

Search ClinicalTrials for Gastrointestinal System Disease

Search NIH Clinical Center for Gastrointestinal System Disease

Search CenterWatch for Gastrointestinal System Disease

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Gastrointestinal System Disease

Anatomical Context for Gastrointestinal System Disease

Sources:
14FMA
See all sources

FMA organs/tissues related to Gastrointestinal System Disease:

14
The gastrointestinal tract

Animal Models for Gastrointestinal System Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Gastrointestinal System Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.2PER2, TAC1, EHD3, MYD88
2MP:000538710.2CD19, MS4A1, LAP3, PTH, CD80, CD86
3MP:000538410.2CD80, CXCR3, MS4A1, MYD88, CD86, CD19
4MP:000539710.0CD80, CD86, DNTT, MS4A1, PTH, PER2

Publications for Gastrointestinal System Disease

Sources:
51PubMed
See all sources

Articles related to Gastrointestinal System Disease:

(show all 11)
idTitleAuthorsYear
1
Spectrum of autoantibodies for gastrointestinal autoimmune diseases in systemic lupus erythematosus patients. (24057059)
2013
2
Simultaneous involvement of nervous and gastrointestinal systems in BehAset's disease. (22577280)
2012
3
Helicobacter pylori infection and gastritis: the Systematic Investigation of gastrointestinaL diseases in China (SILC). (21198827)
2011
4
Epidemiology of peptic ulcer disease: endoscopic results of the systematic investigation of gastrointestinal disease in China. (20736940)
2010
5
"Pulmonary hypertension" of the gastrointestinal tract in patients with systemic sclerosis: thoughts on a not (yet) existing disease entity]. (18814097)
2008
6
Biologic therapies against inflammatory bowel disease: a dysregulated immune system and the cross talk with gastrointestinal mucosa hold the key. (20021434)
2008
7
Systemic mastocytosis mimicking inflammatory bowel disease: A case report and discussion of gastrointestinal pathology in systemic mastocytosis. (17063092)
2006
8
Changes in the gastrointestinal system of children with inflammatory systemic connective tissue diseases]. (8657492)
1995
9
Effects of tixocortol pivalate on gastrointestinal disease in systemic mastocytosis: a preliminary study. (2043986)
1991
10
The role of the mast cell in clinical gastrointestinal disease with special reference to systemic mastocytosis. (16799607)
1991
11
The role of the mast cell in clinical gastrointestinal disease with special reference to systemic mastocytosis. (2002261)
1991

Genetic Variations for Gastrointestinal System Disease

Expression for genes affiliated with Gastrointestinal System Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Gastrointestinal System Disease

Search GEO for disease gene expression data for Gastrointestinal System Disease.

Pathways for genes affiliated with Gastrointestinal System Disease

Sources:
54Reactome, 30KEGG, 38NCBI BioSystems Database
See all sources

Pathways related to Gastrointestinal System Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4MYD88, UBA52
210.4CD19, MS4A1, DNTT
310.4CD80, CD86, CD19, SAA1, LYZ
4
Hide members
10.4CD80, UBA52, CD19, CD86
5
Hide members
10.4CD86, CD80, UBA52, CD19
6
Hide members
10.4UBA52, CD19, CD86, CD80
7
Hide members
10.3PTH, SAA1, NPS, CXCR3, TAC1
8
Hide members
10.3CD86, CD80, CD19, MYD88, UBA52
9
Hide members
10.3UBA52, CD80, CD86, CD19, MYD88, SAA1
10
Hide members
10.2CD86, CD19, CD80, CXCR3, TAC1, PTH

Compounds for genes affiliated with Gastrointestinal System Disease

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 50PharmGKB, 24HMDB, 60Tocris Bioscience
See all sources

Compounds related to Gastrointestinal System Disease according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
1flagellin45 2911.7MYD88, CXCR3, CD86
2belatacept45 1111.7CD80, CD86
3abatacept45 1111.6CD86, CD80
4endotoxin4510.6SAA1, MYD88, CXCR3, CD86
5dexamethasone45 50 29 1113.6DNTT, CD86, TAC1, CXCR3, CD80, PTH
6nitric oxide45 11 2412.5DNTT, PTH, CXCR3, TAC1, CD80, CD86
7allergens4510.5CD80, CXCR3, CD86
8ctla4-ig4510.5CD86, CD80
9calcium45 50 11 2413.5TAC1, PTH, LAP3, MS4A1, CXCR3, CLDN1
10phosphatidylinositol4510.5MYD88, CD80, CXCR3, TAC1, CD19, ALPI
11tyrosine4510.5CD19, MYD88, TYRP1, CD86, PTH, RRM2
12lipid4510.4SAA1, ALPI, LAP3, MS4A1, TAC1, CD19
13bestatin45 29 60 1113.4TAC1, LAP3
14butyrate4510.3CD86, DNTT, ALPI, LAP3
15wortmannin4510.3CXCR3, CD80, CD86, TYRP1
161-chloro-24-dinitrobenzene4510.1CD80, CD86

GO Terms for genes affiliated with Gastrointestinal System Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Gastrointestinal System Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.3CD19, CD86, CD80, CXCR3, MS4A1
2plasma membraneGO:00588610.2UBA52, MYD88, EHD3, CD19, CD86, CD80
3endosome membraneGO:01000810.0UBA52, MYD88, EHD3, TYRP1

Biological processes related to Gastrointestinal System Disease according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1neurotrophin TRK receptor signaling pathwayGO:04801110.6MYD88, CD19, CD86, UBA52, CD80
2fibroblast growth factor receptor signaling pathwayGO:00854310.6CD19, CD86, CD80, UBA52
3positive regulation of action potentialGO:04576010.6TAC1, NPS
4Fc-epsilon receptor signaling pathwayGO:03809510.6UBA52, CD19, CD86, CD80
5innate immune responseGO:04508710.6MYD88, CD86, SAA1, UBA52, CD80, CD19
6positive regulation of synaptic transmission, GABAergicGO:03223010.6TAC1, NPS
7epidermal growth factor receptor signaling pathwayGO:00717310.6CD19, CD86, CD80, UBA52
8positive regulation of signal transductionGO:00996710.5PTH, CD80
9cell-cell signalingGO:00726710.5TAC1, PTH, CD86, CD80
10positive regulation of interleukin-2 biosynthetic processGO:04508610.4CD86, CD80
11toll-like receptor signaling pathwayGO:00222410.4CD86, UBA52, MYD88
12inflammatory responseGO:00695410.3LYZ, TAC1, MYD88, CXCR3
13elevation of cytosolic calcium ion concentrationGO:00720410.1TAC1, CXCR3, SAA1

Products for genes affiliated with Gastrointestinal System Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gastrointestinal System Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet