MCID: GST050
MIFTS: 54

Gastrointestinal System Disease malady

Gastrointestinal diseases category
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Summaries for Gastrointestinal System Disease

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Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
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Wikipedia:65 The human gastrointestinal tract (GI tract) is an organ system responsible for consuming and digesting... more...

MalaCards: Gastrointestinal System Disease, also known as gastrointestinal diseases, is related to pancreatic cancer and esophageal cancer. An important gene associated with Gastrointestinal System Disease is CD19 (CD19 molecule), and among its related pathways are Nectin adhesion pathway and Thyroid cancer. The drugs sacrosidase and belladonna alkaloids and the compounds d-arginine and saikosaponin have been mentioned in the context of this disorder. Affiliated tissues include the gastrointestinal tract, and related mouse phenotypes are tumorigenesis and renal/urinary system.

Disease Ontology:8 A disease of anatomical entity that is located in the gastrointestinal tract.

Aliases & Classifications for Gastrointestinal System Disease

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Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

gastrointestinal system disease 8 10
gastrointestinal diseases 45 62
digestive system disorders 62
digestive system disorder 8
gastrointestinal disorder 8
alimentary system disease 8
gastrointestinal disease 8
gastroenteropathy 8
git disease 8


External Ids:

Disease Ontology8 DOID:77
NCIt40 C2990
MeSH35 D004066
ICD9CM27 520-579.99
ICD1025 11, K92.2, K92.8

Related Diseases for Gastrointestinal System Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Gastrointestinal System Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 486)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatic cancer29.7PTGS2, JUN, BAX, CDH1, HRAS
2esophageal cancer29.7PTGS2, CDH1
3colon cancer29.6PTGS2, JUN, BAX, CDH1, HRAS
4inflammatory bowel disease29.6PTGS2, ALPI, NOS2
5vascular disease29.6JUN, KNG1, NOS2
6recurrent acute pancreatitis10.4
7cholecystitis10.3
8irritable bowel syndrome10.3
9gastrojejunal ulcer10.3
10gastric ulcer10.3
11eosinophilic gastroenteritis10.2
12galactosemia10.2
13abdominal wall defect10.2
14congenital chloride diarrhea10.2
15chronic diarrhea due to guanylate cyclase 2c overactivity10.2
16perinatal intestinal perforation10.2
17perinatal necrotizing enterocolitis10.2
18pancreas disease10.2
19microvillus inclusion disease10.2
20congenital malabsorptive diarrhea 410.2
21benign recurrent intrahepatic cholestasis10.2
22diarrhea 5, with tufting enteropathy, congenital10.2
23diarrhea 710.2
24meconium ileus10.2
25diarrhea 3, secretory sodium, congenital, syndromic10.2
26congenital enterocyte heparan sulfate deficiency10.2
27epithelio-exfoliative colitis - deafness10.2
28appendicitis10.1
29hepatitis10.1
30protein-losing enteropathy10.1
31gastritis10.1
32dyspepsia10.1
33eating disorder10.1
34congenital diaphragmatic hernia10.1
35leukemia, acute lymphoblastic 310.1CD19, DNTT
36pleurisy10.0KNG1, PTGS2
37angioedema10.0KNG1, PTGS2
38chronic lymphocytic leukemia10.0DNTT, BAX, CD19
39renal fibrosis10.0KNG1, CDH1
40gallbladder cancer10.0BAX, CDH1
41hydrops of gallbladder10.0
42occlusion of gallbladder10.0
43strawberry gallbladder10.0
44perforation of bile duct10.0
45acute orbital inflammation10.0
46biliary tract disease10.0
47cholangitis10.0
48cholestasis10.0
49gallbladder disease10.0
50intestinal disease10.0

Graphical network of the top 20 diseases related to Gastrointestinal System Disease:



Diseases related to gastrointestinal system disease

Symptoms for Gastrointestinal System Disease

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Drugs & Therapeutics for Gastrointestinal System Disease

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Genetic Tests for Gastrointestinal System Disease

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Anatomical Context for Gastrointestinal System Disease

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Sources:
14FMA
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FMA organs/tissues related to Gastrointestinal System Disease:

14
The gastrointestinal tract

Animal Models for Gastrointestinal System Disease or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Gastrointestinal System Disease:

37 (show all 16)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5PTGS2, NOS2, CD19, CDH1, HRAS
2MP:00053678.5PTGS2, BAX, NOS2, CD19, HRAS
3MP:00053888.3PTGS2, JUN, BAX, NOS2, HRAS
4MP:00053908.1PTGS2, JUN, BAX, NOS2, HRAS
5MP:00028738.1PTGS2, JUN, DNTT, CD19, CDH1, HRAS
6MP:00053798.0PTGS2, JUN, BAX, NOS2, CDH1, HRAS
7MP:00053858.0PTGS2, JUN, NOS2, CD19, CDH1, HRAS
8MP:00053867.9PTGS2, JUN, BAX, NOS2, CD19, HRAS
9MP:00036317.9HRAS, CD19, NOS2, BAX, JUN, PTGS2
10MP:00107717.9PTGS2, CLDN1, JUN, NOS2, CD19, CDH1
11MP:00053977.8PTGS2, JUN, DNTT, BAX, NOS2, CD19
12MP:00053877.5PTGS2, JUN, DNTT, BAX, NOS2, CD19
13MP:00053847.5PTGS2, JUN, BAX, NOS2, CD19, CDH1
14MP:00053787.5PTGS2, CLDN1, JUN, BAX, NOS2, CD19
15MP:00107687.4PTGS2, CLDN1, JUN, BAX, NOS2, CD19
16MP:00053767.1HRAS, PTGS2, CLDN1, JUN, BAX, KNG1

Publications for Gastrointestinal System Disease

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Variations for Gastrointestinal System Disease

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Expression for genes affiliated with Gastrointestinal System Disease

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gastrointestinal System Disease

Search GEO for disease gene expression data for Gastrointestinal System Disease.

Pathways for genes affiliated with Gastrointestinal System Disease

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Sources:
50PathCards, 38NCBI BioSystems Database, 30KEGG, 53QIAGEN, 60Thomson Reuters, 55Reactome, 54R&D Systems, 61Tocris Bioscience, 51PharmGKB
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Pathways related to Gastrointestinal System Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CDH1, CLDN1
29.7CDH1, HRAS
39.7HRAS, CDH1
49.7HRAS, JUN
59.7HRAS, JUN
6
Show member pathways
AhR pathway38
9.6JUN, BAX
79.6BAX, JUN
89.4HRAS, KNG1, BAX
9
Show member pathways
9.4JUN, CD19, HRAS
10
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
9.4HRAS, CD19, JUN
11
Show member pathways
9.4HRAS, CD19, JUN
12
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility60
Cytoskeleton remodeling Integrin outside in signaling60
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases60
Cell adhesion Tight junctions60
Development MAG dependent inhibition of neurite outgrowth60
9.4CLDN1, JUN, HRAS
139.4JUN, BAX, CD19
14
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
9.3JUN, BAX, HRAS
15
Show member pathways
9.3JUN, BAX, HRAS
16
Show member pathways
9.3JUN, BAX, HRAS
17
Show member pathways
Prostate Cancer38
Integrated Cancer pathway38
Steroid Biosynthesis38
9.3JUN, BAX, HRAS
189.3JUN, BAX, HRAS
19
Show member pathways
Apoptosis and survival BAD phosphorylation60
Development Alpha 2 adrenergic receptor activation of ERK60
Chemotaxis CXCR4 signaling pathway60
9.3JUN, BAX, HRAS
20
Show member pathways
9.3HRAS, BAX, JUN
219.3HRAS, BAX, JUN
22
Show member pathways
9.3HRAS, BAX, JUN
23
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
9.3HRAS, CDH1, JUN
249.3HRAS, CDH1, JUN
25
Show member pathways
RAC1 signaling pathway38
9.3HRAS, CDH1, JUN
269.3JUN, CDH1, HRAS
279.2CDH1, BAX, JUN
28
Show member pathways
9.1HRAS, JUN, PTGS2
29
Show member pathways
9.1HRAS, JUN, PTGS2
309.1PTGS2, BAX, CDH1
31
Show member pathways
9.0HRAS, CD19, BAX, JUN
329.0BAX, JUN, PTGS2
33
Show member pathways
9.0HRAS, CDH1, JUN, CLDN1
34
Show member pathways
8.9JUN, BAX, CDH1, HRAS
35
Show member pathways
8.9JUN, BAX, CDH1, HRAS
36
Show member pathways
Signal transduction PTEN pathway60
8.9JUN, BAX, CDH1, HRAS
37
Show member pathways
8.9NOS2, JUN, PTGS2
388.9NOS2, JUN, PTGS2
39
Show member pathways
Immune response MIF in innate immunity response60
8.9NOS2, JUN, PTGS2
408.9PTGS2, JUN, NOS2
41
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.8JUN, BAX, NOS2, HRAS
42
Show member pathways
Prolactin Signaling Pathway38
Development Prolactin receptor signaling60
Leptin signaling pathway38
8.8JUN, BAX, NOS2, HRAS
43
Show member pathways
8.8PTGS2, JUN, CD19, HRAS
44
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells38
8.8PTGS2, JUN, CD19, HRAS
45
Show member pathways
8.7PTGS2, JUN, BAX, HRAS
46
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor38
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
8.7PTGS2, JUN, BAX, HRAS
478.7CDH1, JUN, CLDN1, PTGS2
48
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
8.6HRAS, NOS2, JUN, PTGS2
49
Show member pathways
8.3PTGS2, JUN, BAX, CDH1, HRAS
507.8HRAS, CDH1, NOS2, BAX, JUN, PTGS2

Compounds for genes affiliated with Gastrointestinal System Disease

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Sources:
45Novoseek, 24HMDB, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 29IUPHAR, 3BitterDB
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Compounds related to Gastrointestinal System Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 114)
idCompoundScoreTop Affiliating Genes
1d-arginine45 24 1111.8NOS2, KNG1
2saikosaponin459.8BAX, JUN
3ketorolac45 1110.6PTGS2, NOS2
4exisulind459.5CDH1, PTGS2, BAX
5sulindac sulfide459.4BAX, PTGS2, JUN
6vinblastine45 51 1111.4CDH1, BAX, JUN
7c2ceramide459.4BAX, NOS2, JUN
8cyclopentenone459.3PTGS2, JUN, NOS2
9silymarin459.2NOS2, JUN, PTGS2
10sulindac45 1110.2PTGS2, BAX, HRAS, CDH1
11gf 109203x45 6110.1PTGS2, HRAS, KNG1, JUN
1215-deoxy-delta-12,14-prostaglandin j2459.1JUN, NOS2, PTGS2
13mg 13245 6110.1JUN, BAX, NOS2, CDH1
1412-o-tetradecanoylphorbol 13-acetate459.0HRAS, CDH1, DNTT, JUN
154-hydroxynonenal45 2410.0NOS2, BAX, JUN
16troglitazone45 29 61 1112.0BAX, JUN, PTGS2, CDH1
17celecoxib45 61 29 51 24 1114.0BAX, PTGS2, CDH1, NOS2
18doxorubicin45 51 1111.0CD19, BAX, NOS2, CDH1, HRAS
19quercetin45 61 24 1111.9DNTT, NOS2, BAX, JUN
20pdtc458.9JUN, NOS2, PTGS2
21triptolide458.9BAX, JUN, NOS2, PTGS2
22ciglitazone45 299.9NOS2, PTGS2, BAX, JUN
23sulforaphane458.9NOS2, BAX, JUN, PTGS2
24wortmannin458.9BAX, HRAS, CDH1, JUN
25resveratrol45 61 24 1111.9BAX, PTGS2, JUN, NOS2
26indomethacin45 29 61 1111.9NOS2, KNG1, PTGS2, CDH1
27paraffin458.8HRAS, BAX, DNTT, CDH1
28irinotecan45 51 1110.8CDH1, PTGS2, BAX
29pd 98,059458.7HRAS, CDH1, PTGS2, JUN, BAX
30adenylate458.7HRAS, CDH1, NOS2, DNTT, KNG1
31arachidonic acid45 29 24 1111.6KNG1, DNTT, PTGS2, HRAS, CDH1
32herbimycin a45 619.6NOS2, JUN, CDH1, HRAS, PTGS2
33cisplatin45 51 61 1111.6HRAS, CDH1, BAX, PTGS2, DNTT
34actinomycin d458.5PTGS2, JUN, BAX, KNG1, NOS2
35egcg458.5NOS2, BAX, CDH1, JUN, PTGS2
36curcumin458.5JUN, BAX, NOS2, CDH1, PTGS2
37etoposide45 51 61 1111.5CDH1, BAX, PTGS2, DNTT, JUN
38n acetylcysteine458.5BAX, PTGS2, NOS2, CDH1, JUN
39sb 20358045 619.5CDH1, NOS2, BAX, JUN, PTGS2
40cycloheximide458.5BAX, JUN, KNG1, PTGS2, NOS2
41nitric oxide45 24 1110.3HRAS, NOS2, KNG1, PTGS2, DNTT
42butyrate458.3JUN, DNTT, ALPI, BAX, CDH1
43ly294002458.2CDH1, BAX, NOS2, JUN, PTGS2, HRAS
44dexamethasone45 51 29 1111.2PTGS2, NOS2, CDH1, DNTT, JUN
45vegf458.2CDH1, PTGS2, JUN, BAX, NOS2, HRAS
46estrogen458.1BAX, NOS2, HRAS, JUN, PTGS2, CDH1
47phosphatidylinositol457.9HRAS, ALPI, BAX, CDH1, KNG1, JUN
48genistein45 29 61 3 24 1112.9HRAS, CDH1, NOS2, PTGS2, JUN, BAX
49calcium45 51 24 1110.8HRAS, CLDN1, ALPI, KNG1, NOS2, CD19
50pge2457.7JUN, DNTT, KNG1, NOS2, CDH1, HRAS

GO Terms for genes affiliated with Gastrointestinal System Disease

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Sources:
16Gene Ontology
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Cellular components related to Gastrointestinal System Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lateral plasma membraneGO:0163289.8CDH1, CLDN1

Biological processes related to Gastrointestinal System Disease according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of DNA replicationGO:0457409.8HRAS, JUN
2release of cytochrome c from mitochondriaGO:0018369.8JUN, BAX
3cellular response to UVGO:0346449.7BAX, PTGS2
4Fc-epsilon receptor signaling pathwayGO:0380959.6HRAS, CD19, JUN
5negative regulation of neuron apoptotic processGO:0435249.6HRAS, BAX, JUN
6positive regulation of neuron apoptotic processGO:0435259.5BAX, JUN
7learningGO:0076129.4JUN, PTGS2
8positive regulation of apoptotic processGO:0430659.2PTGS2, BAX, KNG1
9positive regulation of smooth muscle cell proliferationGO:0486619.1JUN, PTGS2
10response to drugGO:0424939.1CDH1, JUN, PTGS2
11inflammatory responseGO:0069549.0PTGS2, KNG1, NOS2

Products for genes affiliated with Gastrointestinal System Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gastrointestinal System Disease

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet