MCID: GST050
MIFTS: 54

Gastrointestinal System Disease malady

Gastrointestinal diseases category

Summaries for Gastrointestinal System Disease

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 The human gastrointestinal tract (GI tract) is an organ system responsible for consuming and digesting... more...

MalaCards: Gastrointestinal System Disease, also known as gastrointestinal diseases, is related to colon cancer and recurrent acute pancreatitis. An important gene associated with Gastrointestinal System Disease is CD19 (CD19 molecule), and among its related pathways are IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation and Hematopoietic cell lineage. The drugs prednisolone and prednisone and the compounds flagellin and belatacept have been mentioned in the context of this disorder. Affiliated tissues include the gastrointestinal tract, and related mouse phenotypes are renal/urinary system and immune system.

Disease Ontology:8 A disease of anatomical entity that is located in the gastrointestinal tract.

Aliases & Classifications for Gastrointestinal System Disease

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 27ICD9CM, 56SNOMED-CT, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

gastrointestinal system disease 8 10
gastrointestinal diseases 44 60
digestive system disorders 60
alimentary system disease 8
gastrointestinal disorder 8
digestive system disorder 8
gastrointestinal disease 8
gastroenteropathy 8
git disease 8


External Ids:

Disease Ontology8 DOID:77
MeSH34 D004066
ICD9CM27 520-579.99
NCIt39 C2990
ICD1025 11, K92.2, K92.8

Related Diseases for Gastrointestinal System Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Gastrointestinal System Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 172)
idRelated DiseaseScoreTop Affiliating Genes
1colon cancer29.7ALPI, RRM2, TAC1, CD80
2recurrent acute pancreatitis10.4
3cholecystitis10.3
4irritable bowel syndrome10.2
5eosinophilic gastroenteritis10.2
6gastroenteritis10.2
7congenital chloride diarrhea10.1
8chronic diarrhea due to guanylate cyclase 2c overactivity10.1
9perinatal intestinal perforation10.1
10pancreas disease10.1
11cholestasis, progressive familial intrahepatic 110.1
12microvillus inclusion disease10.1
13congenital malabsorptive diarrhea 410.1
14benign recurrent intrahepatic cholestasis10.1
15diarrhea 5, with tufting enteropathy, congenital10.1
16meconium ileus10.1
17diarrhea 3, secretory sodium, congenital, syndromic10.1
18congenital chronic diarrhea with protein-losing enteropathy10.1
19congenital enterocyte heparan sulfate deficiency10.1
20epithelio-exfoliative colitis - deafness10.1
21protein-losing enteropathy10.1
22food allergy10.1
23gastritis10.1
24dyspepsia10.1
25eating disorder10.1
26systemic mastocytosis10.0
27perforation of bile duct10.0
28hydrops of gallbladder10.0
29occlusion of gallbladder10.0
30perinatal necrotizing enterocolitis10.0
31strawberry gallbladder10.0
32acute orbital inflammation10.0
33biliary tract disease10.0
34cholangitis10.0
35gallbladder disease10.0
36autoimmune pancreatitis10.0
37benign recurrent intrahepatic cholestasis 210.0
38primary sclerosing cholangitis10.0
39cholestasis, progressive familial intrahepatic 210.0
40cholestasis, progressive familial intrahepatic 310.0
41gallbladder disease 110.0
42pancreatitis, chronic10.0
43fibrocalculous pancreatic diabetes10.0
44meconium ileus in cystic fibrosis10.0
45autoimmune pancreatitis type 210.0
46autoimmune pancreatitis type 110.0
47crohn's disease10.0LYZ
48nephritis10.0CXCR3
49psoriasis10.0NPS, CXCR3, TAC1
50lupus nephritis10.0CXCR3, DNTT

Graphical network of the top 20 diseases related to Gastrointestinal System Disease:



Diseases related to gastrointestinal system disease

Clinical Features for Gastrointestinal System Disease

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Drugs & Therapeutics for Gastrointestinal System Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Gastrointestinal System Disease

Drug clinical trials:

Search ClinicalTrials for Gastrointestinal System Disease

Search NIH Clinical Center for Gastrointestinal System Disease

Search CenterWatch for Gastrointestinal System Disease

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Gastrointestinal System Disease

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Anatomical Context for Gastrointestinal System Disease

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Sources:
14FMA
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FMA organs/tissues related to Gastrointestinal System Disease:

14
The gastrointestinal tract

Animal Models for Gastrointestinal System Disease or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Gastrointestinal System Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.2MYD88, EHD3, TAC1, PER2
2MP:000538710.2PTH, MYD88, DNTT, CD19, CD86, CD80
3MP:000538410.2EHD3, DNTT, CD19, CD86, CD80, CXCR3
4MP:000539710.0MYD88, DNTT, CD19, CD86, CD80, MS4A1

Publications for Gastrointestinal System Disease

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Sources:
50PubMed
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Articles related to Gastrointestinal System Disease:

idTitleAuthorsYear
1
Spectrum of autoantibodies for gastrointestinal autoimmune diseases in systemic lupus erythematosus patients. (24057059)
2013
2
Simultaneous involvement of nervous and gastrointestinal systems in BehAset's disease. (22577280)
2012
3
"Pulmonary hypertension" of the gastrointestinal tract in patients with systemic sclerosis: thoughts on a not (yet) existing disease entity]. (18814097)
2008
4
Biologic therapies against inflammatory bowel disease: a dysregulated immune system and the cross talk with gastrointestinal mucosa hold the key. (20021434)
2008
5
Systemic mastocytosis mimicking inflammatory bowel disease: A case report and discussion of gastrointestinal pathology in systemic mastocytosis. (17063092)
2006
6
Changes in the gastrointestinal system of children with inflammatory systemic connective tissue diseases]. (8657492)
1995
7
Effects of tixocortol pivalate on gastrointestinal disease in systemic mastocytosis: a preliminary study. (2043986)
1991
8
The role of the mast cell in clinical gastrointestinal disease with special reference to systemic mastocytosis. (16799607)
1991
9
The role of the mast cell in clinical gastrointestinal disease with special reference to systemic mastocytosis. (2002261)
1991

Genetic Variations for Gastrointestinal System Disease

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Expression for genes affiliated with Gastrointestinal System Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gastrointestinal System Disease

Search GEO for disease gene expression data for Gastrointestinal System Disease.

Pathways for genes affiliated with Gastrointestinal System Disease

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Sources:
53Reactome, 29KEGG, 37NCBI BioSystems Database
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Pathways related to Gastrointestinal System Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4MYD88, UBA52
210.4CD19, MS4A1, DNTT
310.4CD80, CD86, CD19, SAA1, LYZ
4
Hide members
10.4CD80, UBA52, CD19, CD86
5
Hide members
10.4CD86, CD80, UBA52, CD19
6
Hide members
10.4UBA52, CD19, CD86, CD80
7
Hide members
10.3PTH, SAA1, NPS, CXCR3, TAC1
8
Hide members
10.3CD86, CD80, CD19, MYD88, UBA52
9
Hide members
10.3UBA52, CD80, CD86, CD19, MYD88, SAA1
10
Hide members
10.2CD86, CD19, CD80, CXCR3, TAC1, PTH

Compounds for genes affiliated with Gastrointestinal System Disease

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB, 59Tocris Bioscience
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Compounds related to Gastrointestinal System Disease according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
1flagellin44 2811.7MYD88, CD86, CXCR3
2belatacept44 1111.7CD86, CD80
3abatacept44 1111.6CD86, CD80
4endotoxin4410.6CXCR3, CD86, MYD88, SAA1
5dexamethasone44 49 28 1113.6SAA1, DNTT, CD86, CD80, CXCR3, TAC1
6nitric oxide44 11 2412.5MYD88, DNTT, CD86, CD80, CXCR3, TAC1
7allergens4410.5CD86, CD80, CXCR3
8ctla4-ig4410.5CD80, CD86
9calcium44 49 11 2413.5ALPI, SAA1, TYRP1, CD19, CD80, CLDN1
10phosphatidylinositol4410.5MYD88, CD19, CD80, CXCR3, TAC1, ALPI
11tyrosine4410.5MYD88, TYRP1, CD19, CD86, CD80, CXCR3
12lipid4410.4SAA1, MYD88, CD19, TAC1, MS4A1, LAP3
13bestatin44 28 59 1113.4LAP3, TAC1
14butyrate4410.3DNTT, CD86, LAP3, ALPI
151-chloro-24-dinitrobenzene4410.3CD86, CD80
16wortmannin4410.1TYRP1, CD86, CD80, CXCR3

GO Terms for genes affiliated with Gastrointestinal System Disease

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Sources:
16Gene Ontology
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Cellular components related to Gastrointestinal System Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.3MS4A1, CXCR3, CD80, CD86, CD19
2plasma membraneGO:00588610.2MYD88, EHD3, CD19, CD86, CD80, CXCR3
3endosome membraneGO:01000810.0UBA52, MYD88, EHD3, TYRP1

Biological processes related to Gastrointestinal System Disease according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1neurotrophin TRK receptor signaling pathwayGO:04801110.6CD80, CD86, CD19, MYD88, UBA52
2fibroblast growth factor receptor signaling pathwayGO:00854310.6UBA52, CD19, CD86, CD80
3positive regulation of action potentialGO:04576010.6TAC1, NPS
4Fc-epsilon receptor signaling pathwayGO:03809510.6CD80, CD86, CD19, UBA52
5innate immune responseGO:04508710.6UBA52, SAA1, MYD88, CD19, CD86, CD80
6positive regulation of synaptic transmission, GABAergicGO:03223010.6TAC1, NPS
7epidermal growth factor receptor signaling pathwayGO:00717310.6UBA52, CD19, CD86, CD80
8positive regulation of signal transductionGO:00996710.5PTH, CD80
9cell-cell signalingGO:00726710.5CD86, CD80, TAC1, PTH
10positive regulation of interleukin-2 biosynthetic processGO:04508610.4CD86, CD80
11toll-like receptor signaling pathwayGO:00222410.4CD86, MYD88, UBA52
12inflammatory responseGO:00695410.3LYZ, TAC1, CXCR3, MYD88
13elevation of cytosolic calcium ion concentrationGO:00720410.1SAA1, CXCR3, TAC1

Products for genes affiliated with Gastrointestinal System Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gastrointestinal System Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet