MCID: GST050
MIFTS: 47

Gastrointestinal System Disease malady

Gastrointestinal diseases category

Aliases & Classifications for Gastrointestinal System Disease

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 61UMLS, 56SNOMED-CT, 39NCIt, 33MeSH, 27ICD9CM, 25ICD10
See all sources

Aliases & Descriptions for Gastrointestinal System Disease:

Name: Gastrointestinal System Disease 8 10
Gastrointestinal Diseases 44 61
Digestive System Disorders 61
Alimentary System Disease 8
Gastrointestinal Disorder 8
 
Digestive System Disorder 8
Gastrointestinal Disease 8
Gastroenteropathy 8
Git Disease 8


Classifications:



External Ids:

Disease Ontology8 DOID:77
NCIt39 C2990
MeSH33 D004066
ICD9CM27 520-579.99
ICD1025 11, K92.2, K92.8

Summaries for Gastrointestinal System Disease

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Disease Ontology:8 A disease of anatomical entity that is located in the gastrointestinal tract.

MalaCards based summary: Gastrointestinal System Disease, also known as gastrointestinal diseases, is related to esophageal cancer and vascular disease. An important gene associated with Gastrointestinal System Disease is CD19 (CD19 molecule), and among its related pathways are Nectin adhesion pathway and Thyroid cancer. The drugs belladonna alkaloids and dicyclomine and the compounds d-arginine and saikosaponin have been mentioned in the context of this disorder. Affiliated tissues include the gastrointestinal tract, and related mouse phenotypes are tumorigenesis and renal/urinary system.

Related Diseases for Gastrointestinal System Disease

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Diseases related to Gastrointestinal System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 390)
idRelated DiseaseScoreTop Affiliating Genes
1esophageal cancer30.0PTGS2, CDH1
2vascular disease29.4KNG1, NOS2, JUN
3pancreatic cancer29.3HRAS, BAX, CDH1, JUN, PTGS2
4irritable bowel syndrome10.3
5gastrojejunal ulcer10.3
6gastric ulcer10.3
7eosinophilic gastroenteritis10.2
8gastroenteritis10.2
9galactosemia10.2
10cholecystitis10.2
11abdominal wall defect10.2
12precursor b-cell acute lymphoblastic leukemia10.2DNTT, CD19
13cholestasis, benign recurrent intrahepatic10.2
14cholestasis, progressive familial intrahepatic 110.2
15perinatal intestinal perforation10.2
16perinatal necrotizing enterocolitis10.2
17pleurisy10.2KNG1, PTGS2
18angioedema10.2PTGS2, KNG1
19chronic lymphocytic leukemia10.1DNTT, CD19, BAX
20renal fibrosis10.1CDH1, KNG1
21protein-losing enteropathy10.1
22gastritis10.1
23dyspepsia10.1
24eating disorder10.1
25precursor t-cell acute lymphoblastic leukemia10.1HRAS, BAX, DNTT
26gallbladder cancer10.1BAX, CDH1
27appendicitis10.1
28congenital diaphragmatic hernia10.1
29congenital heart disease10.1KNG1, BAX, DNTT
30follicular adenoma10.1HRAS, CDH1
31thyroid carcinoma, papillary10.0BAX, CDH1, HRAS
32eye disease10.0BAX, DNTT, JUN
33cholestasis, benign recurrent intrahepatic, 210.0
34cholangitis, primary sclerosing10.0
35meconium ileus10.0
36cholestasis, progressive familial intrahepatic 210.0
37cholestasis, progressive familial intrahepatic 310.0
38intestinal obstruction10.0
39bladder cancer, somatic10.0BAX, CDH1, HRAS
40cystic fibrosis10.0
41hepatitis10.0
42systemic mastocytosis10.0
43mastocytosis10.0
44pleomorphic adenoma10.0HRAS, NOS2
45skin benign neoplasm10.0JUN, HRAS
46celiac disease10.0
47atopy10.0
48cyclic vomiting syndrome10.0
49leukemia, acute promyelocytic10.0BAX, DNTT, JUN
50myeloma10.0HRAS, DNTT, CD19, BAX

Graphical network of the top 20 diseases related to Gastrointestinal System Disease:



Diseases related to gastrointestinal system disease

Symptoms for Gastrointestinal System Disease

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Drugs & Therapeutics for Gastrointestinal System Disease

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Genetic Tests for Gastrointestinal System Disease

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Anatomical Context for Gastrointestinal System Disease

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FMA organs/tissues related to Gastrointestinal System Disease:

14
The gastrointestinal tract

Animal Models for Gastrointestinal System Disease or affiliated genes

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MGI Mouse Phenotypes related to Gastrointestinal System Disease:

35 (show all 16)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5HRAS, CDH1, CD19, NOS2, PTGS2
2MP:00053678.5PTGS2, BAX, CD19, NOS2, HRAS
3MP:00053888.3JUN, PTGS2, NOS2, BAX, HRAS
4MP:00053908.1HRAS, JUN, BAX, NOS2, PTGS2
5MP:00028738.1DNTT, PTGS2, JUN, CD19, CDH1, HRAS
6MP:00053798.0PTGS2, JUN, BAX, CDH1, HRAS, NOS2
7MP:00053858.0JUN, HRAS, CD19, CDH1, PTGS2, NOS2
8MP:00053867.9HRAS, NOS2, JUN, PTGS2, CD19, BAX
9MP:00036317.9HRAS, PTGS2, BAX, NOS2, CD19, JUN
10MP:00107717.9CDH1, CLDN1, PTGS2, NOS2, CD19, JUN
11MP:00053977.8BAX, CD19, DNTT, JUN, PTGS2, NOS2
12MP:00053877.5JUN, PTGS2, CDH1, CD19, NOS2, BAX
13MP:00053847.5CDH1, CD19, NOS2, BAX, PTGS2, JUN
14MP:00053787.5CDH1, CD19, NOS2, BAX, JUN, HRAS
15MP:00107687.4CDH1, HRAS, CD19, NOS2, BAX, JUN
16MP:00053767.1HRAS, CDH1, CD19, NOS2, KNG1, BAX

Publications for Gastrointestinal System Disease

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Variations for Gastrointestinal System Disease

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Expression for genes affiliated with Gastrointestinal System Disease

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Search GEO for disease gene expression data for Gastrointestinal System Disease.

Pathways for genes affiliated with Gastrointestinal System Disease

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Pathways related to Gastrointestinal System Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 61)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CDH1, CLDN1
29.7CDH1, HRAS
39.7CDH1, HRAS
49.7HRAS, JUN
59.7JUN, HRAS
6
Show member pathways
AhR pathway36
9.6BAX, JUN
79.6BAX, JUN
89.4BAX, HRAS, KNG1
9
Show member pathways
9.4JUN, CD19, HRAS
10
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
9.4JUN, CD19, HRAS
11
Show member pathways
9.4HRAS, JUN, CD19
12
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility59
Cytoskeleton remodeling Integrin outside in signaling59
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases59
Cell adhesion Tight junctions59
Development MAG dependent inhibition of neurite outgrowth59
9.4CLDN1, JUN, HRAS
139.4CD19, JUN, BAX
14
Show member pathways
9.3JUN, BAX, HRAS
159.3JUN, BAX, HRAS
16
Show member pathways
Apoptosis and survival BAD phosphorylation59
Development Alpha 2 adrenergic receptor activation of ERK59
Chemotaxis CXCR4 signaling pathway59
9.3JUN, BAX, HRAS
179.3BAX, HRAS, JUN
18
Show member pathways
Prostate Cancer36
Integrated Cancer pathway36
Steroid Biosynthesis36
9.3HRAS, JUN, BAX
19
Show member pathways
9.3BAX, JUN, HRAS
20
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes59
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway59
9.3HRAS, JUN, BAX
21
Show member pathways
9.3HRAS, BAX, JUN
22
Show member pathways
9.3BAX, JUN, HRAS
23
Show member pathways
Development ERBB family signaling59
Development GDNF family signaling59
9.3JUN, CDH1, HRAS
249.3JUN, CDH1, HRAS
25
Show member pathways
RAC1 signaling pathway36
9.3HRAS, CDH1, JUN
269.3HRAS, JUN, CDH1
279.2JUN, BAX, CDH1
28
Show member pathways
9.1HRAS, JUN, PTGS2
29
Show member pathways
9.1HRAS, PTGS2, JUN
309.1PTGS2, BAX, CDH1
31
Show member pathways
9.0CD19, HRAS, JUN, BAX
329.0JUN, BAX, PTGS2
33
Show member pathways
9.0CDH1, JUN, CLDN1, HRAS
34
Show member pathways
8.9CDH1, BAX, JUN, HRAS
35
Show member pathways
8.9JUN, BAX, CDH1, HRAS
36
Show member pathways
Signal transduction PTEN pathway59
8.9BAX, HRAS, CDH1, JUN
378.9NOS2, JUN, PTGS2
388.9PTGS2, JUN, NOS2
39
Show member pathways
8.9NOS2, PTGS2, JUN
40
Show member pathways
Immune response MIF in innate immunity response59
8.9JUN, PTGS2, NOS2
41
Show member pathways
Prolactin Signaling Pathway36
Development Prolactin receptor signaling59
Leptin signaling pathway36
8.8BAX, NOS2, HRAS, JUN
42
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.8HRAS, BAX, JUN, NOS2
43
Show member pathways
8.8PTGS2, JUN, CD19, HRAS
44
Show member pathways
Immune response BCR pathway59
Fc-epsilon receptor I signaling in mast cells36
8.8HRAS, CD19, JUN, PTGS2
45
Show member pathways
8.7HRAS, JUN, PTGS2, BAX
46
Show member pathways
Development EGFR signaling via PIP359
Development PDGF signaling via MAPK cascades59
Apoptosis and survival Anti apoptotic action of membrane bound ESR159
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases59
Development Neurotrophin family signaling59
Apoptosis and survival NGF signaling pathway59
Apoptosis and survival Role of CDK5 in neuronal death and survival59
8.7BAX, HRAS, JUN, PTGS2
478.7JUN, CDH1, CLDN1, PTGS2
48
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways59
Immune response IL 1 signaling pathway59
8.6PTGS2, HRAS, NOS2, JUN
49
Show member pathways
8.3JUN, BAX, PTGS2, HRAS, CDH1
507.8PTGS2, CDH1, NOS2, BAX, JUN, HRAS

Compounds for genes affiliated with Gastrointestinal System Disease

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Compounds related to Gastrointestinal System Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 114)
idCompoundScoreTop Affiliating Genes
1d-arginine44 24 1111.8NOS2, KNG1
2saikosaponin449.8BAX, JUN
3ketorolac44 1110.6PTGS2, NOS2
4exisulind449.5CDH1, PTGS2, BAX
5sulindac sulfide449.4BAX, PTGS2, JUN
6vinblastine44 50 1111.4CDH1, BAX, JUN
7c2ceramide449.4BAX, NOS2, JUN
8cyclopentenone449.3PTGS2, JUN, NOS2
9silymarin449.2NOS2, JUN, PTGS2
10sulindac44 1110.2PTGS2, BAX, HRAS, CDH1
11gf 109203x44 6010.1PTGS2, HRAS, KNG1, JUN
1215-deoxy-delta-12,14-prostaglandin j2449.1JUN, NOS2, PTGS2
13mg 13244 6010.1JUN, BAX, NOS2, CDH1
1412-o-tetradecanoylphorbol 13-acetate449.0HRAS, CDH1, DNTT, JUN
154-hydroxynonenal44 2410.0NOS2, BAX, JUN
16troglitazone44 28 60 1112.0BAX, JUN, PTGS2, CDH1
17celecoxib44 60 28 50 24 1114.0BAX, PTGS2, CDH1, NOS2
18doxorubicin44 50 1111.0CD19, BAX, NOS2, CDH1, HRAS
19quercetin44 60 24 1111.9DNTT, NOS2, BAX, JUN
20pdtc448.9JUN, NOS2, PTGS2
21triptolide448.9BAX, JUN, NOS2, PTGS2
22ciglitazone44 289.9NOS2, PTGS2, BAX, JUN
23sulforaphane448.9NOS2, BAX, JUN, PTGS2
24wortmannin448.9BAX, HRAS, CDH1, JUN
25resveratrol44 60 24 1111.9BAX, PTGS2, JUN, NOS2
26indomethacin44 28 60 1111.9NOS2, KNG1, PTGS2, CDH1
27paraffin448.8HRAS, BAX, DNTT, CDH1
28irinotecan44 50 1110.8CDH1, PTGS2, BAX
29pd 98,059448.7HRAS, CDH1, PTGS2, JUN, BAX
30adenylate448.7HRAS, CDH1, NOS2, DNTT, KNG1
31arachidonic acid44 28 24 1111.6KNG1, DNTT, PTGS2, HRAS, CDH1
32herbimycin a44 609.6NOS2, JUN, CDH1, HRAS, PTGS2
33cisplatin44 50 60 1111.6HRAS, CDH1, BAX, PTGS2, DNTT
34actinomycin d448.5PTGS2, JUN, BAX, KNG1, NOS2
35egcg448.5NOS2, BAX, CDH1, JUN, PTGS2
36curcumin448.5JUN, BAX, NOS2, CDH1, PTGS2
37etoposide44 50 60 1111.5CDH1, BAX, PTGS2, DNTT, JUN
38n acetylcysteine448.5BAX, PTGS2, NOS2, CDH1, JUN
39sb 20358044 609.5CDH1, NOS2, BAX, JUN, PTGS2
40cycloheximide448.5BAX, JUN, KNG1, PTGS2, NOS2
41nitric oxide44 24 1110.3HRAS, NOS2, KNG1, PTGS2, DNTT
42butyrate448.3JUN, DNTT, ALPI, BAX, CDH1
43ly294002448.2CDH1, BAX, NOS2, JUN, PTGS2, HRAS
44dexamethasone44 50 28 1111.2PTGS2, NOS2, CDH1, DNTT, JUN
45vegf448.2CDH1, PTGS2, JUN, BAX, NOS2, HRAS
46estrogen448.1BAX, NOS2, HRAS, JUN, PTGS2, CDH1
47phosphatidylinositol447.9HRAS, ALPI, BAX, CDH1, KNG1, JUN
48genistein44 28 60 1 24 1112.9HRAS, CDH1, NOS2, PTGS2, JUN, BAX
49calcium44 50 24 1110.8HRAS, CLDN1, ALPI, KNG1, NOS2, CD19
50pge2447.7JUN, DNTT, KNG1, NOS2, CDH1, HRAS

GO Terms for genes affiliated with Gastrointestinal System Disease

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Cellular components related to Gastrointestinal System Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lateral plasma membraneGO:00163289.8CDH1, CLDN1

Biological processes related to Gastrointestinal System Disease according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of DNA replicationGO:00457409.8HRAS, JUN
2release of cytochrome c from mitochondriaGO:00018369.8JUN, BAX
3cellular response to UVGO:00346449.7BAX, PTGS2
4Fc-epsilon receptor signaling pathwayGO:00380959.6HRAS, CD19, JUN
5negative regulation of neuron apoptotic processGO:00435249.6HRAS, BAX, JUN
6positive regulation of neuron apoptotic processGO:00435259.5BAX, JUN
7learningGO:00076129.4JUN, PTGS2
8positive regulation of apoptotic processGO:00430659.2PTGS2, BAX, KNG1
9positive regulation of smooth muscle cell proliferationGO:00486619.1JUN, PTGS2
10response to drugGO:00424939.1CDH1, JUN, PTGS2
11inflammatory responseGO:00069549.0PTGS2, KNG1, NOS2

Sources for Gastrointestinal System Disease

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet