MCID: GST050
MIFTS: 56

Gastrointestinal System Disease malady

Categories: Gastrointestinal diseases

Aliases & Classifications for Gastrointestinal System Disease

Aliases & Descriptions for Gastrointestinal System Disease:

Name: Gastrointestinal System Disease 12 14
Gastrointestinal Diseases 52 69
Gastrointestinal Disease 12 14
Digestive System Disorders 69
Alimentary System Disease 12
Digestive System Disorder 12
Gastrointestinal Disorder 12
Digestive System Diseases 42
Gastroenteropathy 12
Git Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:77
ICD9CM 35 520-579.99
MeSH 42 D004066
UMLS 69 C0012242

Summaries for Gastrointestinal System Disease

Disease Ontology : 12 A disease of anatomical entity that is located in the gastrointestinal tract.

MalaCards based summary : Gastrointestinal System Disease, also known as gastrointestinal diseases, is related to lymphocytic gastritis and celiac disease, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Gastrointestinal System Disease is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Peptide ligand-binding receptors and Allograft rejection. The drugs Ethanol and Heparin have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and small intestine, and related phenotypes are digestive/alimentary and homeostasis/metabolism

Wikipedia : 71 Gastrointestinal diseases refer to diseases involving the gastrointestinal tract, namely the esophagus,... more...

Related Diseases for Gastrointestinal System Disease

Diseases related to Gastrointestinal System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 235)
id Related Disease Score Top Affiliating Genes
1 lymphocytic gastritis 30.1 ATP12A ATP4A CCL11
2 celiac disease 10.8
3 gastritis, familial giant hypertrophic 10.8
4 eosinophilic enteropathy 10.8
5 gallbladder disease 10.6
6 esophageal atresia/tracheoesophageal fistula 10.6
7 mucositis 10.6
8 diarrhea 10.6
9 mouth disease 10.6
10 intestinal disease 10.6
11 esophageal disease 10.6
12 stomach disease 10.6
13 peritonitis 10.6
14 lactase deficiency, congenital 10.6
15 post-vaccinal encephalitis 10.5 GAST SCT
16 intussusception 10.5 IL1B TNF
17 tricuspid valve insufficiency 10.5 ATP4A CCK SCT
18 female stress incontinence 10.5 CCK CCKAR SCT
19 congenital dyserythropoietic anemia 10.5 ALB TNF
20 inhalation anthrax 10.5 ALB ATP4A TRPV1
21 breast malignant eccrine spiradenoma 10.5 CCK GAST SCT
22 angiomatosis, diffuse corticomeningeal, of divry and van bogaert 10.5 GHRL IL6 TNF
23 cataract 10.5 ALB IL1B TNF
24 childhood endodermal sinus tumor 10.5 IL1B TNF TRPV1
25 mandibular cancer 10.5 CCK CCKAR GHRL TRPV1
26 vein disease 10.5 ATP4A GAST S100A8
27 myocardial stunning 10.5 CCK GAST MLN
28 amyotrophic lateral sclerosis type 10 10.5 ATP12A ATP4A NOD2
29 glucosephosphate dehydrogenase deficiency 10.5 ALB IL1B IL6
30 bipolar i disorder 10.5 IL1B IL6 TNF
31 secondary syphilis 10.5 ATP12A ATP4A GAST
32 brain edema 10.5 ATP12A ATP4A GAST
33 generalized epilepsy with febrile seizures plus 10.5 ATP4A IL1B TRPV1
34 porencephaly, cerebellar hypoplasia, and internal malformations 10.5 ALB ATP12A ATP4A
35 human immunodeficiency virus infectious disease 10.5 IL1B IL6 TNF
36 peripheral degeneration of cornea 10.5 GCG PYY SCT
37 amyotrophic lateral sclerosis type 14 10.5 IL1B NOD2 TNF
38 measles 10.5 IL1B IL6 TNF
39 meier-gorlin syndrome 3 10.5 IL1B NOD2 TNF
40 dextrocardia 10.5 IL1B IL6 TNF
41 hypoparathyroidism-retardation-dysmorphism syndrome 10.5 IL1B IL6 TNF
42 steroid dehydrogenase deficiency dental anomalies 10.5 IL1B IL6 TNF
43 liver rhabdomyosarcoma 10.5 ATP12A ATP4A GAST
44 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.5 IL6 TNF
45 benign neonatal seizures 10.5 IL1B IL6 TNF
46 rheumatoid factor-negative juvenile idiopathic arthritis without anti-nuclear antibodies 10.5 IL1B IL6 TNF
47 mesenteric vascular occlusion 10.5 ATP12A ATP4A PYY
48 gonococcal endophthalmia 10.5 IL1B IL6 TNF
49 cholesteatoma 10.5 ALB CCK GHRL PYY
50 ectodermal dysplasia bartalos type 10.5 IL1B IL6 TNF

Graphical network of the top 20 diseases related to Gastrointestinal System Disease:



Diseases related to Gastrointestinal System Disease

Symptoms & Phenotypes for Gastrointestinal System Disease

UMLS symptoms related to Gastrointestinal System Disease:


abdominal pain, constipation, diarrhea, dyspepsia, halitosis, heartburn, icterus, nausea and vomiting, oral manifestations, pathological conditions, signs and symptoms, signs and symptoms of ill-defined conditions, digestive system symptom, gastrointestinal gas, abdomen, acute, abdominal cramps, eructation, flatulence, flatulence, eructation, and gas pain, glossalgia, nausea, rectal pain, signs and symptoms, digestive, vomiting, tongue discoloration, liver tender, symptoms involving digestive system, other symptoms involving digestive system, odynophagia, abdominal discomfort, upper abdominal pain, lower abdominal pain, retching, rectal tenesmus, dry throat, hyperemesis, abdominal distress, epigastric pain not food-related, right upper quadrant pain, epigastric food-related pain, upset stomach, abdominal fullness, salivary gland pain, abdominal distention, gaseous, edema of mouth, anal pain, burning tongue, infantile colic, vomiting in newborn, change in bowel habits, stomach cramps (finding), gastric irritation, swallowing problems, gastrointestinal symptoms, sore lip, gastrointestinal pain, vomiting alone, abdominal distress/pain as reason for lower g.i. examination, abdominal distress/pain as reason for upper g.i. examination, anal discomfort, abdominal bloating, epigastric discomfort, blood in stool, catarrh, peeling tongue

MGI Mouse Phenotypes related to Gastrointestinal System Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.61 ALB ATP12A ATP4A CCKAR GAST GHRL
2 homeostasis/metabolism MP:0005376 9.47 NOD2 PYY TNF TRPV1 ALB ATP12A

Drugs & Therapeutics for Gastrointestinal System Disease

Drugs for Gastrointestinal System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1172)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 64-17-5 702
2
Heparin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 9005-49-6 772 46507594
3
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
4
Clonidine Approved Phase 4,Phase 3,Phase 2,Phase 1 4205-90-7 2803
5
Nitric Oxide Approved Phase 4,Phase 1,Phase 2 10102-43-9 145068
6
Mannitol Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 69-65-8 453 6251
7
Baclofen Approved Phase 4,Phase 3,Phase 2,Phase 1 1134-47-0 2284
8
Rosiglitazone Approved, Investigational Phase 4,Phase 2 122320-73-4 77999
9
Ezetimibe Approved Phase 4,Phase 2 163222-33-1 150311
10
Pioglitazone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 111025-46-8 4829
11
Simvastatin Approved Phase 4,Phase 2,Phase 3,Phase 1 79902-63-9 54454
12
Zinc Approved Phase 4,Phase 2,Phase 3,Phase 1 7440-66-6 32051 23994
13
Tacrolimus Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 104987-11-3 445643 439492
14
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-78-2 2244
15
Colchicine Approved Phase 4,Phase 3,Phase 1 64-86-8 6167 2833
16
Cisplatin Approved Phase 4,Phase 3,Phase 2 15663-27-1 84093 441203 2767
17
Loperamide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 53179-11-6 3955
18
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
19
Midazolam Approved, Illicit Phase 4,Phase 2,Phase 3,Phase 1 59467-70-8 4192
20
Ursodeoxycholic acid Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 128-13-2 31401
21
Iron Approved Phase 4,Phase 3,Phase 1,Phase 2 7439-89-6 23925
22
Indomethacin Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 53-86-1 3715
23
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2 24280-93-1 446541
24
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 2 128794-94-5 5281078
25
Pantoprazole Approved Phase 4,Phase 3,Phase 2,Phase 1 102625-70-7 4679
26
Diclofenac Approved, Vet_approved Phase 4,Phase 1 15307-86-5 3033
27
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 73590-58-6 4594
28
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 85721-33-1 2764
29
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 57-27-2 5288826
30
Acetaminophen Approved Phase 4,Phase 3,Phase 2 103-90-2 1983
31
Lamivudine Approved, Investigational Phase 4,Phase 1,Phase 2 134678-17-4 60825
32
Metformin Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 657-24-9 14219 4091
33
Losartan Approved Phase 4,Phase 3,Phase 2 114798-26-4 3961
34
Spironolactone Approved Phase 4,Phase 2,Phase 3 1952-01-7, 52-01-7 5833
35
Amlodipine Approved Phase 4,Phase 1,Phase 2 88150-42-9 2162
36
Carvedilol Approved, Investigational Phase 4,Phase 3 72956-09-3 2585
37
Diltiazem Approved Phase 4,Phase 3,Phase 1 42399-41-7 39186
38
Glycerol Approved, Experimental Phase 4,Phase 3,Phase 2 56-81-5 753
39
Azathioprine Approved Phase 4,Phase 2,Phase 3,Phase 1 446-86-6 2265
40
Ribavirin Approved Phase 4,Phase 3,Phase 2,Phase 1 36791-04-5 37542
41
Histamine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 75614-87-8, 51-45-6 774
42
Propranolol Approved, Investigational Phase 4,Phase 2,Phase 3 525-66-6 4946
43
Adalimumab Approved Phase 4,Phase 3,Phase 2,Phase 1 331731-18-1 16219006
44
Hydrocortisone Approved, Vet_approved Phase 4,Phase 2,Phase 1 50-23-7 5754 657311
45
Naloxone Approved, Vet_approved Phase 4,Phase 3,Phase 1 465-65-6 5284596
46
Infliximab Approved Phase 4,Phase 2,Phase 3,Phase 1 170277-31-3
47
Nadolol Approved Phase 4,Phase 3 42200-33-9 39147
48
Selenium Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 7782-49-2
49
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
50
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189

Interventional clinical trials:

(show top 50) (show all 5425)
id Name Status NCT ID Phase
1 The Treatment of Periodontal Diseases Unknown status NCT01318928 Phase 4
2 Prophylactic Pancreatic Duct Stent Placement After ESP of Major Papillary Tumors; Prospective, Randomized Study Unknown status NCT01737463 Phase 4
3 Gastric Functions & Proton Pump Inhibitor( PPI) Study Unknown status NCT00951431 Phase 4
4 THE USE OF N-ACETYLCYSTEINE ATTENUATING CISPLATIN-INDUCED TOXICITIES BY OXIDATIVE STRESS Unknown status NCT02241876 Phase 4
5 Prospective Random Comparing Study on EUS-guided Pseudocyst Drainage by Naso-pancreatic Tube and Stents Unknown status NCT01585662 Phase 4
6 The Risk of Bleeding After Removal of Large Colorectal Polyps in Patients Taking Aspirin Unknown status NCT01549418 Phase 4
7 The Effect of Vitamin D3 to Maintain Surgical Remission in Postoperative Crohn's Disease Unknown status NCT02010762 Phase 4
8 Diverticulitis: Antibiotics or Close Observation? Unknown status NCT01111253 Phase 4
9 Placebo Controlled Study of Baclofen for GERD in Children With Cerebral Palsy Unknown status NCT01386255 Phase 4
10 Placebo Controlled Study Using Lovaza as Treatment for Non-Alcoholic Fatty Liver Disease Unknown status NCT00941642 Phase 4
11 The Effect Of Dual Treatment With L-Carnitine And Magnesium On Fatty Liver Unknown status NCT01956825 Phase 4
12 A Study of Thymoglobulin and Tacrolimus in Liver Transplant Unknown status NCT00564538 Phase 4
13 Effect of an Artificial Pancreas in Patients Undergoing Pancreatic Resection Unknown status NCT00661648 Phase 4
14 Intravenous-Morphine and Glucagon-Usage Enhanced MR Cholangiography Unknown status NCT00155376 Phase 4
15 The Orange-III Trial: Optimised Recovery With Movicol® Preoperatively Within an Enhanced Recovery Programme Unknown status NCT01429779 Phase 4
16 Double- Versus Single-balloon Enteroscopy for Obscure Small-bowel Bleeding Unknown status NCT01176864 Phase 4
17 Pharmacokinetics of Caspofungin After One Dose in Patients With Liver Failure Unknown status NCT01968395 Phase 4
18 SILS™ Port Laparoscopic Cholecystectomy Post Market Study Unknown status NCT00832767 Phase 4
19 Lifestyle Versus Ezetimibe Plus Lifestyle in Patients With Non-alcoholic Steatohepatitis Unknown status NCT01950884 Phase 4
20 Epidural Analgesia for Pancreatitis (Epipan Study) Unknown status NCT02126332 Phase 4
21 Endoscopic Cyanoacrylate Obliteration vs. Nadolol Treatment in the Prevention of Gastric Variceal Rebleeding Unknown status NCT00567216 Phase 4
22 TO Compare the Triple Drug Therapy and Dual Therapy . Unknown status NCT02075242 Phase 4
23 A Trial of EVL\GVS Alone vs. EVL\GVS Combined Propranolol Unknown status NCT01298284 Phase 4
24 Multi-center Clinical Study of Early Antibios of Severe Acute Pancreatitis Unknown status NCT01992198 Phase 4
25 Comparative Study About the Impact of Two Oil Emulsions Administered Intravenously on Severe Acute Pancreatitis Unknown status NCT01376817 Phase 4
26 Single-Operator Versus Dual-Operator Double-balloon Endoscopy in Patients With Small-Bowel Disorders Unknown status NCT01184690 Phase 4
27 The Impact of Rockall Risk Scoring System on Management of Upper Gastrointestinal System Bleeding Unknown status NCT01269814 Phase 4
28 Outcome Study of Double Bare Stent for Malignant Gastric Outlet Obstruction Unknown status NCT02156505 Phase 4
29 A Double Blind Study Comparing Two Doses of IV Esomeprazole After Successful Endoscopic Therapy Unknown status NCT01275937 Phase 4
30 Comparison of Oral Rabeprazole vs. iv Omeprazole in Mild to Moderate Nonvariceal Upper Gastrointestinal Bleeding Unknown status NCT00861640 Phase 4
31 Study of Long-Term Peg Intron Vs. Colchicine in Non-Responders. Unknown status NCT00179413 Phase 4
32 Telbivudine Renoprotective Effect in Patients With the HBV-related Liver Cirrhosis: a Randomized Controlled Trial Unknown status NCT01799486 Phase 4
33 Telbivudine Renoprotective Effect in Patients With HBV-related Liver Cirrhosis Unknown status NCT01693679 Phase 4
34 Development of an Imaging Biomarker for Hepatic Fibrosis Using Gadoxetate Disodium Unknown status NCT01783314 Phase 4
35 Magnesium in Liver Cirrhosis Unknown status NCT01894867 Phase 4
36 Endoscopic Band Ligation (EBL) Versus Propranolol for Primary Prophylaxis of Variceal Bleeding Unknown status NCT00965900 Phase 4
37 Efficacy and Safety of Floseal for the Haemostasis During Laparoscopic Cholecystectomy in Acute Cholecystitis (GLA) Unknown status NCT01126281 Phase 4
38 Effect of Betablocker or Aldosterone Antagonist Therapy on Patients With Liver Cirrhosis Unknown status NCT00332904 Phase 4
39 Rifaximin Predicts the Complications of Decompensated Cirrhosis Unknown status NCT02074280 Phase 4
40 RCT of Carvedilol Versus Variceal Band Ligation in the Primary Prophylaxis of Oesophageal Variceal Haemorrhage Unknown status NCT01070641 Phase 4
41 Echocardiographic Assessment of Intrapulmonary Vasodilatation: Agitated Saline Versus Polygeline Unknown status NCT00343122 Phase 4
42 Confocal Endomicroscopy During Endoscopy Unknown status NCT00988273 Phase 4
43 Withholding Feeds During Red Blood Cell Transfusion and TRAGI Unknown status NCT02132819 Phase 4
44 Efficacy and Safety of Ursodeoxycholic Acid (UDCA) Added to the DPP-4 Inhibitor in People With Type 2 Diabetes and Chronic Liver Diseases Unknown status NCT01337440 Phase 4
45 The Effect of Probiotics on Exacerbation of Inflammatory Bowel Disease Exacerbation (Crohn's Disease) Unknown status NCT01765998 Phase 4
46 A Prospective, Placebo Controlled, Double-Blind, Cross-over Study on the Effects of a Probiotic Preparation (VSL#3) on Metabolic Profile, Intestinal Permeability, Microbiota, Cytokines and Chemokines Expression and Other Inflammatory Markers in Pediatric Unknown status NCT01632462 Phase 4
47 Use of Combined Measurements of Serum Infliximab and Anti-infliximab Antibodies in the Treatment of Patients With Crohns Disease Failing Infliximab Therapy Unknown status NCT00851565 Phase 4
48 Evaluation of PET CT in the Management of Patients With Crohn's Disease. Unknown status NCT00731809 Phase 4
49 The Effect of Probiotics on the Rate of Recovery of Inflammatory Bowel Disease Exacerbation, Endothelial Function, and Markers of Inflammation Unknown status NCT01078935 Phase 4
50 Comparison of a Nutritional Anti-Inflammatory Treatment to Steroids for Pediatric Crohn's Disease - the Molecular Basis Unknown status NCT00265772 Phase 4

Search NIH Clinical Center for Gastrointestinal System Disease

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: digestive system diseases

Genetic Tests for Gastrointestinal System Disease

Anatomical Context for Gastrointestinal System Disease

MalaCards organs/tissues related to Gastrointestinal System Disease:

39
Liver, Pancreas, Small Intestine, Tongue, Salivary Gland

The Foundational Model of Anatomy Ontology organs/tissues related to Gastrointestinal System Disease:

18
The Gastrointestinal Tract

Publications for Gastrointestinal System Disease

Variations for Gastrointestinal System Disease

Expression for Gastrointestinal System Disease

Search GEO for disease gene expression data for Gastrointestinal System Disease.

Pathways for Gastrointestinal System Disease

Pathways related to Gastrointestinal System Disease according to GeneCards Suite gene sharing:

(show all 26)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.45 CCK CCKAR GCG GHRL HTR4 MLN
2
Show member pathways
12.76 CCL11 IL1B IL6 MADCAM1 TNF
3
Show member pathways
12.24 ALB IL1B IL6 TNF
4 12.13 IL1B IL6 NOD2 TNF
5
Show member pathways
12.08 CCL11 IL1B IL6 TNF
6
Show member pathways
11.89 CCL11 IL1B IL6 S100A8 TNF
7 11.76 IL1B IL6 TNF
8 11.73 CCL11 IL1B IL6 TNF
9 11.67 IL1B IL6 TNF
10 11.67 IL1B IL6 TNF
11 11.62 IL6 MADCAM1 TNF
12 11.59 IL1B IL6 NOD2 TNF
13
Show member pathways
11.57 IL1B IL6 TNF
14 11.48 IL1B IL6 TNF
15 11.41 IL1B IL6 TNF
16 11.4 IL1B IL6 TNF
17 11.32 IL1B IL6 TNF
18 11.2 IL1B IL6 TNF
19 11.18 IL1B IL6 TNF
20 11.12 CCL11 IL1B IL6 TNF
21 11.11 IL1B IL6 TNF
22 11.07 IL1B IL6 TNF
23 11.06 CCL11 IL1B IL6 TNF
24 10.97 IL1B IL6 TNF