MCID: GST037
MIFTS: 56

Gastroparesis malady

Gastrointestinal diseases category
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Summaries for Gastroparesis

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Wikipedia:65 Gastroparesis (gastro-, \"stomach\" + -paresis, \"partial paralysis\"), also called delayed gastric... more...

MalaCards based summary: Gastroparesis, also known as gastroparalysis, is related to dyspepsia and morbid obesity. An important gene associated with Gastroparesis is GHRL (ghrelin/obestatin prepropeptide), and among its related pathways are Gastrin-CREB signalling pathway via PKC and MAPK and Peptide ligand-binding receptors. The drugs metoclopramide and cisapride and the compounds ipamorelin and ghrp-6 have been mentioned in the context of this disorder. Affiliated tissues include small intestine, lung and heart, and related mouse phenotypes are adipose tissue and behavior/neurological.

Aliases & Classifications for Gastroparesis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 34MeSH, 27ICD9CM, 57SNOMED-CT, 39NCIt
See all sources

Gastroparesis, Aliases & Descriptions:

Name: Gastroparesis 8 10 44 62
Gastroparalysis 8 62
 
Gastric Atonia 8 62
Gastroparesis Syndrome 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology8 DOID:11914
MeSH34 D018589
ICD9CM27 536.3
NCIt39 C80512

Related Diseases for Gastroparesis

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Diseases related to Gastroparesis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 90)
idRelated DiseaseScoreTop Affiliating Genes
1dyspepsia31.1CCK, GHRL
2morbid obesity30.5CCK, GHRL
3obesity30.1CCK, GHRL, GHSR, NOS1
4lung cancer30.0CCK, NOS1, GHRL
5diabetes mellitus10.4
6pyloric stenosis10.4NOS1
7neuropathy10.3
8parkinson's disease10.3
9blindness10.3
10anorexia nervosa10.2GHRL, CCK
11growth hormone deficiency10.2GHRL, GHSR
12double outlet right ventricle10.2CCK, GHRL
13neuronitis10.2
14pancreatitis10.2
15bulimia nervosa10.2GHRL, CCK
16glucagonoma10.2CCK, GHRL
17cushing's syndrome10.2GHSR, GHRL
18gastrointestinal system disease10.2CCK, GHRL
19eating disorder10.2GHRL, CCK
20glucose intolerance10.2CCK, GHRL
21thyroid medullary carcinoma10.2GHRL, CCK
22celiac disease10.2CCK, GHRL
23short stature10.2GHSR, GHRL
24pituitary tumors10.2GHRL, GHSR
25type 1 diabetes mellitus10.2
26constipation10.2
27esophagitis10.2
28dysphagia10.2
29hypothyroidism10.2GHSR, GHRL
30gastritis10.2CCK, GHRL
31insulinoma10.2GHRL, GHSR
32neuroepithelioma10.1CCK, NOS1
33hirschsprung's disease10.1NOS1, HMOX2
34psychotic disorder10.1CCK, NOS1
35pituitary adenoma10.1GHRL, GHSR
36cholangiocarcinoma10.1
37multiple sclerosis10.1
38pancreatic cancer10.1
39gastroduodenitis10.1
40autonomic neuropathy10.1
41demyelinating disease10.1
42intestinal pseudo-obstruction10.1
43autonomic dysfunction10.1
44prader-willi syndrome10.0CCK, GHSR, GHRL
45acromegaly10.0CCK, GHSR, GHRL
46neuroendocrine tumor10.0GHRL, CCK, GHSR
47carcinoid syndrome10.0CCK, GHRL, GHSR
48hyperglycemia10.0CCK, GHRL, GHSR
49hyperinsulinism10.0GHRL, CCK
50vascular disease10.0GHRL, NOS1

Graphical network of the top 20 diseases related to Gastroparesis:



Diseases related to gastroparesis

Symptoms for Gastroparesis

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Drugs & Therapeutics for Gastroparesis

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Drug clinical trials:

Search ClinicalTrials for Gastroparesis

Search NIH Clinical Center for Gastroparesis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Gastroparesis

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Anatomical Context for Gastroparesis

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MalaCards organs/tissues related to Gastroparesis:

32
Small intestine, Lung, Heart, Testes, Kidney, Pancreas, Bone marrow, Bone, Spinal cord

Animal Models for Gastroparesis or affiliated genes

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MGI Mouse Phenotypes related to Gastroparesis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.7GHSR, NOS1, GHRL
2MP:00053868.5GHSR, GHRL, NOS1, HMOX2
3MP:00053817.6GHRL, KCNE2, GHSR, HMOX2, NOS1
4MP:00053767.0NOS1, KCNE2, CCK, GHRL, GHSR, HMOX2

Publications for Gastroparesis

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Articles related to Gastroparesis:

(show top 50)    (show all 527)
idTitleAuthorsYear
1
Treatment of functional dyspepsia and gastroparesis. (25169218)
2014
2
SIBO in Gastroparesis: Sci-fi or Science Fact? (24435184)
2014
3
Curcumin improves expression of ghrelin through attenuating oxidative stress in gastric tissues of streptozotocin-induced diabetic gastroparesis rats. (24036253)
2013
4
Bodyweight in Patients with Idiopathic Gastroparesis: Roles of Symptoms, Caloric Intake, Physical Activity, and Body Metabolism. (24286121)
2013
5
Diagnostic assessment of diabetic gastroparesis. (23881199)
2013
6
Evaluation and Treatment of Gastric Stimulator Failure in Patients With Gastroparesis. (24056201)
2013
7
Minimally invasive surgical approach for the treatment of gastroparesis. (22752276)
2013
8
Through-the-scope transpyloric stent placement improves symptoms and gastric emptying in patients with gastroparesis. (23824975)
2013
9
Gastric electrical stimulation for treatment of clinically severe gastroparesis. (24250062)
2013
10
Gastric electrical stimulation for abdominal pain in patients with symptoms of gastroparesis. (23635579)
2013
11
Prevalence of gastroparesis before and after lung transplantation and its association with lung allograft outcomes. (22313020)
2012
12
Laparoscopic longitudinal gastrectomy and duodenojejunostomy for treatment of diabetic gastroparesis. (22963822)
2012
13
Prevalence of hidden gastroparesis in the community: the gastroparesis "iceberg". (22323986)
2012
14
Oxytocin prolongs the gastric emptying time in patients with diabetes mellitus and gastroparesis, but does not affect satiety or volume intake in patients with functional dyspepsia. (22420866)
2012
15
Spectrum of gastroparesis in children. (22314391)
2012
16
Platelet-derived growth factor receptor I+ (PDGFRI+)-expressing "fibroblast-like cells" in diabetic and idiopathic gastroparesis of humans. (22650155)
2012
17
Two-channel gastric pacing in patients with diabetic gastroparesis. (21806741)
2011
18
Bloating in gastroparesis: severity, impact, and associated factors. (21483459)
2011
19
Clinical features of idiopathic gastroparesis vary with sex, body mass, symptom onset, delay in gastric emptying, and gastroparesis severity. (20965184)
2011
20
Severe gastroparesis: medical therapy or gastric electrical stimulation. (19765675)
2010
21
Prevalence of gastroparesis in type 1 diabetes mellitus and its relationship to dyspeptic symptoms. (20922192)
2010
22
Advantages of azithromycin over erythromycin in improving the gastric emptying half-time in adult patients with gastroparesis. (21103422)
2010
23
Diabetic gastroparesis: Therapeutic options. (22127672)
2010
24
Delayed radionucleotide gastric emptying studies predict morbidity in diabetics with symptoms of gastroparesis. (19410575)
2009
25
Methods of gastric electrical stimulation and pacing: a review of their benefits and mechanisms of action in gastroparesis and obesity. (19254353)
2009
26
Gastroparesis: current concepts and management. (20431741)
2009
27
Factors associated with symptom response to pyloric injection of botulinum toxin in a large series of gastroparesis patients. (19184429)
2009
28
Gastroparesis associated with high-dose cytosine arabinoside. (18290834)
2008
29
A case report of gastroparesis secondary to acute renal failure. (19024208)
2008
30
Severe paraneoplastic gastroparesis associated with anti-Hu antibodies preceding the manifestation of small-cell lung cancer. (18322883)
2008
31
Simultaneous fundoplication and gastric stimulation in a lung transplant recipient with gastroparesis and reflux. (18765058)
2008
32
Treatment options for patients with severe gastroparesis. (17519490)
2007
33
Gastroparesis in multiple sclerosis. (17548454)
2007
34
Gastroparesis secondary to a demyelinating disease: a case series. (17266755)
2007
35
Overcoming diabetic gastroparesis en route to kidney transplant. (16640536)
2006
36
Mirtazapine for severe gastroparesis unresponsive to conventional prokinetic treatment. (16959934)
2006
37
Treating gastroparesis. (17022124)
2006
38
Severe isolated myopathic gastroparesis: a case report with pathological findings. (17047114)
2006
39
Symptom responses, long-term outcomes and adverse events beyond 3 years of high-frequency gastric electrical stimulation for gastroparesis. (16371079)
2006
40
Relief of acute pain in chronic idiopathic gastroparesis with intravenous phentolamine. (17003080)
2006
41
Gastroparesis after a pylorus-preserving pancreatoduodenectomy. (15864414)
2005
42
Influence of ghrelin on gastric emptying and meal-related symptoms in idiopathic gastroparesis. (16225494)
2005
43
Acute gastroparesis secondary to gastric emphysema: a rare complication of balloon dilation. (15472708)
2004
44
Treatment of Gastroparesis. (15010028)
2004
45
Clinical observation on acupuncture treatment in 35 cases of diabetic gastroparesis. (15510787)
2004
46
A systematic review of surgical therapy for gastroparesis. (14572555)
2003
47
Methods for treating diabetic gastroparesis. (11984224)
2002
48
Advances in diabetic gastroparesis. (12122960)
2002
49
Effects of fedotozine on gastric emptying and upper gastrointestinal symptoms in diabetic gastroparesis. (10886051)
2000
50
The effect of chronic oral domperidone therapy on gastrointestinal symptoms, gastric emptying, and quality of life in patients with gastroparesis. (9177513)
1997

Variations for Gastroparesis

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Expression for genes affiliated with Gastroparesis

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Expression patterns in normal tissues for genes affiliated with Gastroparesis

Search GEO for disease gene expression data for Gastroparesis.

Pathways for genes affiliated with Gastroparesis

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Compounds for genes affiliated with Gastroparesis

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Compounds related to Gastroparesis according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idCompoundScoreTop Affiliating Genes
1ipamorelin4410.1GHRL, GHSR
2ghrp-628 4411.1GHSR, GHRL
3ghrp4410.0GHRL, GHSR
4hexarelin44 2811.0GHRL, GHSR
5octadecaneuropeptide4410.0CCK, GHRL
6decanoic acid44 28 1112.0CCK, GHRL
7rimonabant44 28 1111.9CCK, GHRL
8pramlintide44 1110.9GHRL, CCK
9vapreotide44 28 1111.9GHSR, CCK
10intralipid449.9GHRL, CCK
11pirenzepine44 28 1111.9CCK, GHRL
12oxyntomodulin44 6110.9CCK, GHRL
13orlistat44 61 1111.9CCK, GHRL
14naloxone44 28 50 1112.8CCK, GHRL
15amphetamine44 50 1111.8CCK, GHRL
16lactose44 1110.8CCK, GHRL
17c-peptide449.7GHRL, CCK
18zinc protoporphyrin449.7HMOX2, NOS1
19opiate449.7CCK, GHRL
20capsaicin44 2810.7GHRL, NOS1
21amide449.7GHRL, CCK
22acetaminophen44 2 50 24 1113.6CCK, GHRL
23octreotide44 61 28 1112.5CCK, GHRL, GHSR
24tetrodotoxin44 61 2811.5CCK, NOS1
25acth449.5GHRL, GHSR, CCK
26clozapine44 28 50 1112.4GHRL, NOS1
27ribonucleic acid449.4HMOX2, GHSR, GHRL
28forskolin44 50 1111.4GHRL, GHSR, CCK
29l-nmma449.4GHRL, NOS1, CCK
30atropine44 28 1111.4CCK, GHRL, NOS1
31cocaine44 1110.3GHRL, NOS1, CCK
32corticosterone44 61 2411.3NOS1, GHRL
33carbachol44 28 1111.3CCK, GHRL, NOS1
345-hydroxytryptamine449.3GHRL, NOS1, CCK
35sodium nitroprusside449.3NOS1, CCK
36gaba449.3GHRL, CCK, NOS1
37norepinephrine44 24 1111.2CCK, GHRL, NOS1
38histamine44 28 2411.2CCK, GHRL, NOS1
39carbon449.2CCK, HMOX2, NOS1
40morphine44 50 28 1112.0CCK, NOS1
41adenylate448.9NOS1, GHSR, GHRL, CCK
42glucose448.9CCK, GHRL, HMOX2, GHSR
43testosterone44 61 24 1111.9GHRL, GHSR, NOS1, CCK
44dexamethasone44 50 28 1111.9CCK, GHRL, GHSR, NOS1
45nitric oxide44 24 1110.9NOS1, HMOX2, GHRL, GHSR
46acetylcholine44 50 28 24 1112.8GHRL, NOS1, HMOX2, CCK
47estrogen448.8NOS1, GHRL, GHSR, HMOX2
48glutamate448.8GHRL, CCK, HMOX2, NOS1
49dopamine44 28 24 1111.4HMOX2, CCK, GHRL, NOS1, GHSR
50arginine448.4HMOX2, CCK, GHRL, NOS1, GHSR

GO Terms for genes affiliated with Gastroparesis

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Cellular components related to Gastroparesis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:0304249.5GHRL, CCK

Biological processes related to Gastroparesis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of appetiteGO:0321009.9GHSR, GHRL
2negative regulation of tumor necrosis factor biosynthetic processGO:0425369.9GHSR, GHRL
3negative regulation of interleukin-6 biosynthetic processGO:0454099.9GHSR, GHRL
4negative regulation of interleukin-1 beta productionGO:0326919.9GHRL, GHSR
5growth hormone secretionGO:0302529.8GHRL, GHSR
6adult feeding behaviorGO:0083439.8GHSR, GHRL
7actin polymerization or depolymerizationGO:0081549.8GHSR, GHRL
8decidualizationGO:0466979.8GHRL, GHSR
9hormone-mediated signaling pathwayGO:0097559.7GHSR, GHRL
10negative regulation of insulin secretionGO:0466769.7GHSR, GHRL
11positive regulation of multicellular organism growthGO:0400189.6GHRL, GHSR
12response to hormoneGO:0097259.5GHSR, GHRL
13response to hypoxiaGO:0016669.3NOS1, HMOX2
14negative regulation of inflammatory responseGO:0507289.3GHSR, GHRL

Molecular functions related to Gastroparesis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ion channel bindingGO:0443259.0NOS1, KCNE2

Products for genes affiliated with Gastroparesis

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  • Antibodies
  • Proteins
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Sources for Gastroparesis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet