MCID: GST037
MIFTS: 54

Gastroparesis malady

Gastrointestinal diseases category

Summaries for Gastroparesis

About this section
Sources:
66Wikipedia, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
Wikipedia:66 Gastroparesis (gastro-, \"stomach\" + -paresis, \"partial paralysis\"), also called delayed gastric... more...

MalaCards: Gastroparesis, also known as gastroparesis syndrome, is related to dyspepsia and obesity. An important gene associated with Gastroparesis is GHRL (ghrelin/obestatin prepropeptide), and among its related pathways are Gastrin-CREB signalling pathway via PKC and MAPK and Peptide ligand-binding receptors. The drugs metoclopramide and cisapride and the compounds ipamorelin and ghrp-6 have been mentioned in the context of this disorder. Affiliated tissues include small intestine, lung and heart, and related mouse phenotypes are adipose tissue and behavior/neurological.

Aliases & Classifications for Gastroparesis

About this section
Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 28ICD9CM, 41NCIt, 59SNOMED-CT, 36MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

gastroparesis 9 11 46 63
gastroparesis syndrome 9
gastroparalysis 9
gastric atonia 9


External Ids:

Disease Ontology9 DOID:11914
ICD9CM28 536.3
NCIt41 C80512
MeSH36 D018589

Related Diseases for Gastroparesis

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases related to Gastroparesis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 85)
idRelated DiseaseScoreTop Affiliating Genes
1dyspepsia30.7CCK, GHRL
2obesity30.2NOS1, GHSR, GHRL, CCK
3lung cancer30.2CCK, GHRL, NOS1
4morbid obesity30.0CCK, GHRL
5diabetes mellitus10.4
6neuropathy10.3
7parkinson's disease10.3
8blindness10.3
9neuronitis10.2
10pancreatitis10.2
11type 1 diabetes mellitus10.2
12constipation10.2
13esophagitis10.2
14dysphagia10.2
15pyloric stenosis10.1NOS1
16gastroduodenitis10.1
17autonomic neuropathy10.1
18cholangiocarcinoma10.1
19intestinal pseudo-obstruction10.1
20multiple sclerosis10.1
21pancreatic cancer10.1
22autonomic dysfunction10.1
23anorexia nervosa10.1GHRL, CCK
24growth hormone deficiency10.1GHSR, GHRL
25bulimia nervosa10.1CCK, GHRL
26glucagonoma10.0GHRL, CCK
27cushing's syndrome10.0GHRL, GHSR
28gastrointestinal system disease10.0GHRL, CCK
29eating disorder10.0CCK, GHRL
30glucose intolerance10.0GHRL, CCK
31thyroid medullary carcinoma10.0GHRL, CCK
32celiac disease10.0GHRL, CCK
33short stature10.0GHRL, GHSR
34pituitary tumors10.0GHSR, GHRL
35hypothyroidism10.0GHRL, GHSR
36gastritis10.0GHRL, CCK
37insulinoma10.0GHSR, GHRL
38neuroepithelioma10.0CCK, NOS1
39hirschsprung's disease10.0NOS1, HMOX2
40psychotic disorder10.0CCK, NOS1
41pituitary adenoma10.0GHSR, GHRL
42prader-willi syndrome10.0CCK, GHRL, GHSR
43acromegaly10.0GHSR, GHRL, CCK
44neuroendocrine tumor10.0CCK, GHRL, GHSR
45carcinoid syndrome10.0CCK, GHRL, GHSR
46hyperglycemia10.0CCK, GHRL, GHSR
47hyperinsulinism10.0GHRL, CCK
48vascular disease10.0NOS1, GHRL
49epilepsy syndrome10.0CCK, GHRL, NOS1
50adenoma10.0GHRL, GHSR, NOS1

Graphical network of the top 20 diseases related to Gastroparesis:



Diseases related to gastroparesis

Symptoms for Gastroparesis

About this section

Drugs & Therapeutics for Gastroparesis

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Gastroparesis

Drug clinical trials:

Search ClinicalTrials for Gastroparesis

Search NIH Clinical Center for Gastroparesis

Search CenterWatch for Gastroparesis

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Gastroparesis

About this section

Anatomical Context for Gastroparesis

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Gastroparesis:

34
Small intestine, Lung, Heart, Testes, Kidney, Pancreas, Spinal cord, Bone, Bone marrow

Animal Models for Gastroparesis or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Gastroparesis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.7GHRL, GHSR, NOS1
2MP:00053868.5NOS1, HMOX2, GHSR, GHRL
3MP:00053817.6NOS1, HMOX2, GHSR, GHRL, KCNE2
4MP:00053767.0KCNE2, CCK, GHRL, GHSR, HMOX2, NOS1

Publications for Gastroparesis

About this section
Sources:
53PubMed
See all sources

Articles related to Gastroparesis:

(show top 50)    (show all 504)
idTitleAuthorsYear
1
SIBO in Gastroparesis: Sci-fi or Science Fact? (24435184)
2014
2
Curcumin improves expression of ghrelin through attenuating oxidative stress in gastric tissues of streptozotocin-induced diabetic gastroparesis rats. (24036253)
2013
3
Bodyweight in Patients with Idiopathic Gastroparesis: Roles of Symptoms, Caloric Intake, Physical Activity, and Body Metabolism. (24286121)
2013
4
Diagnostic assessment of diabetic gastroparesis. (23881199)
2013
5
Evaluation and Treatment of Gastric Stimulator Failure in Patients With Gastroparesis. (24056201)
2013
6
Minimally invasive surgical approach for the treatment of gastroparesis. (22752276)
2013
7
Through-the-scope transpyloric stent placement improves symptoms and gastric emptying in patients with gastroparesis. (23824975)
2013
8
Gastric electrical stimulation for treatment of clinically severe gastroparesis. (24250062)
2013
9
Gastric electrical stimulation for abdominal pain in patients with symptoms of gastroparesis. (23635579)
2013
10
Prevalence of gastroparesis before and after lung transplantation and its association with lung allograft outcomes. (22313020)
2012
11
Laparoscopic longitudinal gastrectomy and duodenojejunostomy for treatment of diabetic gastroparesis. (22963822)
2012
12
Prevalence of hidden gastroparesis in the community: the gastroparesis "iceberg". (22323986)
2012
13
Oxytocin prolongs the gastric emptying time in patients with diabetes mellitus and gastroparesis, but does not affect satiety or volume intake in patients with functional dyspepsia. (22420866)
2012
14
Spectrum of gastroparesis in children. (22314391)
2012
15
Platelet-derived growth factor receptor I+ (PDGFRI+)-expressing "fibroblast-like cells" in diabetic and idiopathic gastroparesis of humans. (22650155)
2012
16
Two-channel gastric pacing in patients with diabetic gastroparesis. (21806741)
2011
17
Bloating in gastroparesis: severity, impact, and associated factors. (21483459)
2011
18
Clinical features of idiopathic gastroparesis vary with sex, body mass, symptom onset, delay in gastric emptying, and gastroparesis severity. (20965184)
2011
19
Severe gastroparesis: medical therapy or gastric electrical stimulation. (19765675)
2010
20
Prevalence of gastroparesis in type 1 diabetes mellitus and its relationship to dyspeptic symptoms. (20922192)
2010
21
Advantages of azithromycin over erythromycin in improving the gastric emptying half-time in adult patients with gastroparesis. (21103422)
2010
22
Diabetic gastroparesis: Therapeutic options. (22127672)
2010
23
Acupuncture for symptomatic relief of gastroparesis in a diabetic haemodialysis patient. (20466737)
2010
24
Delayed radionucleotide gastric emptying studies predict morbidity in diabetics with symptoms of gastroparesis. (19410575)
2009
25
Methods of gastric electrical stimulation and pacing: a review of their benefits and mechanisms of action in gastroparesis and obesity. (19254353)
2009
26
Gastroparesis: current concepts and management. (20431741)
2009
27
Factors associated with symptom response to pyloric injection of botulinum toxin in a large series of gastroparesis patients. (19184429)
2009
28
Gastroparesis associated with high-dose cytosine arabinoside. (18290834)
2008
29
A case report of gastroparesis secondary to acute renal failure. (19024208)
2008
30
Severe paraneoplastic gastroparesis associated with anti-Hu antibodies preceding the manifestation of small-cell lung cancer. (18322883)
2008
31
Simultaneous fundoplication and gastric stimulation in a lung transplant recipient with gastroparesis and reflux. (18765058)
2008
32
Treatment options for patients with severe gastroparesis. (17519490)
2007
33
Gastroparesis in multiple sclerosis. (17548454)
2007
34
Gastroparesis secondary to a demyelinating disease: a case series. (17266755)
2007
35
Overcoming diabetic gastroparesis en route to kidney transplant. (16640536)
2006
36
Mirtazapine for severe gastroparesis unresponsive to conventional prokinetic treatment. (16959934)
2006
37
Treating gastroparesis. (17022124)
2006
38
Severe isolated myopathic gastroparesis: a case report with pathological findings. (17047114)
2006
39
Symptom responses, long-term outcomes and adverse events beyond 3 years of high-frequency gastric electrical stimulation for gastroparesis. (16371079)
2006
40
Relief of acute pain in chronic idiopathic gastroparesis with intravenous phentolamine. (17003080)
2006
41
Gastroparesis after a pylorus-preserving pancreatoduodenectomy. (15864414)
2005
42
Influence of ghrelin on gastric emptying and meal-related symptoms in idiopathic gastroparesis. (16225494)
2005
43
Acute gastroparesis secondary to gastric emphysema: a rare complication of balloon dilation. (15472708)
2004
44
Treatment of Gastroparesis. (15010028)
2004
45
Clinical observation on acupuncture treatment in 35 cases of diabetic gastroparesis. (15510787)
2004
46
A systematic review of surgical therapy for gastroparesis. (14572555)
2003
47
Methods for treating diabetic gastroparesis. (11984224)
2002
48
Advances in diabetic gastroparesis. (12122960)
2002
49
Effects of fedotozine on gastric emptying and upper gastrointestinal symptoms in diabetic gastroparesis. (10886051)
2000
50
The effect of chronic oral domperidone therapy on gastrointestinal symptoms, gastric emptying, and quality of life in patients with gastroparesis. (9177513)
1997

Variations for Gastroparesis

About this section

Expression for genes affiliated with Gastroparesis

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Gastroparesis

Search GEO for disease gene expression data for Gastroparesis.

Pathways for genes affiliated with Gastroparesis

About this section
Sources:
51PathCards, 56Reactome, 39NCBI BioSystems Database, 31KEGG
See all sources

Compounds for genes affiliated with Gastroparesis

About this section
Sources:
46Novoseek, 30IUPHAR, 12DrugBank, 62Tocris Bioscience, 52PharmGKB, 3BitterDB, 25HMDB
See all sources

Compounds related to Gastroparesis according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idCompoundScoreTop Affiliating Genes
1ipamorelin4610.1GHSR, GHRL
2ghrp-630 4611.1GHSR, GHRL
3ghrp4610.0GHRL, GHSR
4hexarelin46 3011.0GHSR, GHRL
5decanoic acid46 30 1212.0CCK, GHRL
6octadecaneuropeptide4610.0CCK, GHRL
7rimonabant46 30 1211.9CCK, GHRL
8pramlintide46 1210.9GHRL, CCK
9vapreotide46 30 1211.9GHSR, CCK
10intralipid469.9CCK, GHRL
11pirenzepine46 30 1211.9CCK, GHRL
12oxyntomodulin46 6210.9GHRL, CCK
13orlistat46 62 1211.9GHRL, CCK
14naloxone46 30 52 1212.8CCK, GHRL
15amphetamine46 52 1211.8GHRL, CCK
16lactose46 1210.8GHRL, CCK
17c-peptide469.7CCK, GHRL
18zinc protoporphyrin469.7NOS1, HMOX2
19opiate469.7GHRL, CCK
20capsaicin46 3010.7NOS1, GHRL
21amide469.7GHRL, CCK
22acetaminophen46 3 52 25 1213.6CCK, GHRL
23octreotide46 62 30 1212.5GHSR, GHRL, CCK
24tetrodotoxin46 62 3011.5NOS1, CCK
25acth469.5CCK, GHRL, GHSR
26corticosterone46 62 2511.4NOS1, GHRL
27ribonucleic acid469.4HMOX2, GHSR, GHRL
28forskolin46 52 1211.4GHSR, GHRL, CCK
29l-nmma469.4CCK, GHRL, NOS1
30atropine46 30 1211.4CCK, GHRL, NOS1
31cocaine46 1210.3NOS1, GHRL, CCK
32clozapine46 30 52 1212.3NOS1, GHRL
33carbachol46 30 1211.3NOS1, GHRL, CCK
345-hydroxytryptamine469.3CCK, GHRL, NOS1
35sodium nitroprusside469.3NOS1, CCK
36gaba469.3CCK, GHRL, NOS1
37norepinephrine46 25 1211.2CCK, GHRL, NOS1
38histamine46 30 2511.2NOS1, GHRL, CCK
39carbon469.2NOS1, HMOX2, CCK
40morphine46 52 30 1212.0NOS1, CCK
41adenylate468.9NOS1, GHSR, GHRL, CCK
42glucose468.9CCK, GHRL, GHSR, HMOX2
43testosterone46 62 25 1211.9CCK, GHRL, GHSR, NOS1
44dexamethasone46 52 30 1211.9CCK, GHRL, GHSR, NOS1
45nitric oxide46 25 1210.9NOS1, HMOX2, GHSR, GHRL
46acetylcholine46 52 30 25 1212.8NOS1, HMOX2, GHRL, CCK
47estrogen468.8NOS1, HMOX2, GHSR, GHRL
48glutamate468.8CCK, GHRL, HMOX2, NOS1
49dopamine46 30 25 1211.4NOS1, HMOX2, GHSR, GHRL, CCK
50arginine468.4CCK, GHRL, GHSR, HMOX2, NOS1

GO Terms for genes affiliated with Gastroparesis

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Gastroparesis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:0304249.5GHRL, CCK

Biological processes related to Gastroparesis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of appetiteGO:0321009.9GHSR, GHRL
2negative regulation of tumor necrosis factor biosynthetic processGO:0425369.9GHSR, GHRL
3negative regulation of interleukin-6 biosynthetic processGO:0454099.9GHSR, GHRL
4negative regulation of interleukin-1 beta productionGO:0326919.9GHRL, GHSR
5growth hormone secretionGO:0302529.8GHRL, GHSR
6adult feeding behaviorGO:0083439.8GHSR, GHRL
7actin polymerization or depolymerizationGO:0081549.8GHSR, GHRL
8decidualizationGO:0466979.8GHRL, GHSR
9hormone-mediated signaling pathwayGO:0097559.7GHSR, GHRL
10negative regulation of insulin secretionGO:0466769.7GHSR, GHRL
11positive regulation of multicellular organism growthGO:0400189.6GHRL, GHSR
12response to hormoneGO:0097259.5GHSR, GHRL
13response to hypoxiaGO:0016669.3NOS1, HMOX2
14negative regulation of inflammatory responseGO:0507289.3GHSR, GHRL

Molecular functions related to Gastroparesis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ion channel bindingGO:0443259.0NOS1, KCNE2

Products for genes affiliated with Gastroparesis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gastroparesis

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet