MCID: GST037
MIFTS: 57

Gastroparesis malady

Gastrointestinal diseases category

Summaries for Gastroparesis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Gastroparesis (gastro-, \"stomach\" + -paresis, \"partial paralysis\"), also called delayed gastric... more...

MalaCards: Gastroparesis, also known as gastroparesis syndrome, is related to dyspepsia and diabetes mellitus. An important gene associated with Gastroparesis is GHRL (ghrelin/obestatin prepropeptide), and among its related pathways are Cell death signalling via NRAGE, NRIF and NADE and Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1). The drugs metoclopramide and cisapride and the compounds ranitidine and caerulein have been mentioned in the context of this disorder. Affiliated tissues include small intestine, lung and heart, and related mouse phenotypes are adipose tissue and digestive/alimentary.

Aliases & Classifications for Gastroparesis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 39NCIt, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

gastroparesis 8 10 44 60
gastroparesis syndrome 8
gastroparalysis 8
gastric atonia 8


External Ids:

Disease Ontology8 DOID:11914
ICD9CM27 536.3
NCIt39 C80512
MeSH34 D018589

Related Diseases for Gastroparesis

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17GeneCards, 18GeneDecks
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Diseases related to Gastroparesis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 102)
idRelated DiseaseScoreTop Affiliating Genes
1dyspepsia30.6CCK, GAST, MLNR, MLN, GHRL, SPAG7
2diabetes mellitus30.5GHRL, MLN, SCT, CCK, GCG
3obesity30.3GCG, CCK, MLN, GHSR, GHRL, NOS1
4pancreatitis30.2GCG, CCK, SCT
5esophagitis30.2GAST
6constipation30.2MLN, CCK
7gastroduodenitis30.0GAST
8morbid obesity30.0GCG, CCK, GHRL
9autonomic neuropathy30.0MLN, GAST, CCK, GCG
10pancreatic cancer30.0GAST, SCT, CCK, GCG
11diabetic autonomic neuropathy29.8MLNR
12cystic fibrosis29.8SCT
13duodenogastric reflux29.8MLN, GAST, CCK
14gallbladder disease29.8CCK, MLNR, MLN
15gastroesophageal reflux disease29.8GCG, CCK, SCT, GAST, MLN
16type 2 diabetes mellitus29.8GHRL, SCT, CCK, GCG
17neuropathy10.3
18parkinson's disease10.2
19neuronitis10.2
20diabetic neuropathy10.2
21lung cancer10.2
22type 1 diabetes mellitus10.1
23gastric dilatation10.0
24cholangiocarcinoma10.0
25intestinal obstruction10.0
26intestinal pseudo-obstruction10.0
27multiple sclerosis10.0
28neuroendocrine tumor10.0GCG
29duodenitis10.0GAST
30multiple endocrine neoplasia10.0GAST
31postcholecystectomy syndrome10.0GAST
32gastric outlet obstruction10.0GAST, MLN
33irritable bowel syndrome10.0MLN, CCK
34pyloric stenosis10.0NOS1, GAST
35dumping syndrome10.0MLN, GCG
36pituitary adenoma10.0GHSR, GHRL
37ileus10.0MLNR, MLN, GHRL
38hyperparathyroidism10.0SCT, GAST
39liver cirrhosis10.0MLN, SCT
40zollinger-ellison syndrome10.0SCT, GAST
41bile reflux10.0CCK
42acromegaly10.0CCK, GHSR, GHRL
43anorexia nervosa10.0GHRL, CCK, GCG
44diarrhea10.0GCG, GAST, MLN
45eating disorder10.0GHRL
46bulimia nervosa10.0CCK, GHRL
47peptic ulcer10.0CCK, SCT, GAST
48steatorrhea10.0SCT, CCK, GCG
49hyperinsulinemic hypoglycemia10.0SCT, GAST
50long qt syndrome 110.0KCNE2, KCNE1

Graphical network of the top 20 diseases related to Gastroparesis:



Diseases related to gastroparesis

Clinical Features for Gastroparesis

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Drugs & Therapeutics for Gastroparesis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Gastroparesis

Search NIH Clinical Center for Gastroparesis

Search CenterWatch for Gastroparesis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Gastroparesis

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Anatomical Context for Gastroparesis

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32MalaCards
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MalaCards organs/tissues related to Gastroparesis:

32
Small intestine, Lung, Heart, Testes, Kidney, Pancreas, Bone, Spinal cord, Bone marrow

Animal Models for Gastroparesis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Gastroparesis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.8ADRA1B, NOS1, GHRL, GHSR, MBOAT4
2MP:00053819.6KCNE1, KCNE2, GAST, GHSR, GHRL, HMOX2
3MP:00053869.0KCNE1, MBOAT4, SCT, GHSR, GHRL, HMOX2
4MP:00053768.8ADRA1B, KCNE1, KCNE2, GCG, CCK, MRC1

Publications for Gastroparesis

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50PubMed
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Articles related to Gastroparesis:

(show top 50)    (show all 509)
idTitleAuthorsYear
1
Curcumin improves expression of ghrelin through attenuating oxidative stress in gastric tissues of streptozotocin-induced diabetic gastroparesis rats. (24036253)
2013
2
Evaluation and Treatment of Gastric Stimulator Failure in Patients With Gastroparesis. (24056201)
2013
3
Efficacy of permanent gastric electrical stimulation for the treatment of gastroparesis and functional dyspepsia in children and adolescents. (23331812)
2013
4
Intractable vomiting: a case of severe gastroparesis after Ramsay Hunt syndrome. (24210969)
2013
5
Prognosis of diabetic gastroparesis--a 25-year evaluation. (23350946)
2013
6
Unusual case of gastroparesis leading to severe gastromegaly with demyelinating disease as a rare cause. (24383263)
2013
7
Prevalence of symptoms suggestive of gastroparesis in a cohort of patients with diabetes mellitus. (23507560)
2013
8
Phase 2b, randomized, double-blind 12-week studies of TZP-102, a ghrelin receptor agonist for diabetic gastroparesis. (23848826)
2013
9
Acid and non-acid reflux in patients refractory to proton pump inhibitor therapy: is gastroparesis a factor? (24115816)
2013
10
Endoscopic intrapyloric injection of botulinum toxin A in the treatment of children with gastroparesis: a retrospective, open-label study. (22248598)
2012
11
Nutritional therapy for the management of diabetic gastroparesis: clinical review. (23055757)
2012
12
Small Intestinal Bacterial Overgrowth in Gastroparesis. (23053897)
2012
13
Prevalence of gastroparesis-related symptoms in an unselected cohort of patients with Type 1 diabetes. (22459243)
2012
14
Novel mutation in spacer region of POLG associated with ataxia neuropathy spectrum and gastroparesis. (22805437)
2012
15
Gastric electrical stimulation for gastroparesis. (22523722)
2012
16
Altered expression of Ano1 variants in human diabetic gastroparesis. (21349842)
2011
17
The role of continuous subcutaneous insulin infusion therapy in patients with diabetic gastroparesis. (21842427)
2011
18
Esophageal dysmotility is more common than gastroparesis in diabetes mellitus and is associated with retinopathy. (22189550)
2011
19
Gastroparesis: pathogenesis, diagnosis and management. (21769117)
2011
20
Gastroparesis: approach, diagnostic evaluation, and management. (21329779)
2011
21
Phenotypic switching in diabetic gastroparesis: mechanism directs therapy. (21875587)
2011
22
Who should be tested for gastroparesis among diabetic patients. (20593061)
2010
23
Carbon monoxide reverses diabetic gastroparesis in NOD mice. (20378827)
2010
24
Not just another case of nausea and vomiting: a review of postinfectious gastroparesis. (20236395)
2010
25
Abdominal pain is a frequent symptom of gastroparesis. (20472097)
2010
26
Gastroparesis: current concepts and management. (20431741)
2009
27
Diagnostic and therapeutic approach to pancreatic cancer-associated gastroparesis: literature review and our experience. (18618259)
2009
28
Motilides: a long and winding road: lessons from mitemcinal (GM-611) on diabetic gastroparesis. (19345243)
2009
29
Functional (non-ulcer) dyspepsia and gastroparesis--differentiating these conditions and practical management approaches. (19668125)
2009
30
A rare cause of dysphagia and gastroparesis. (21686844)
2009
31
Severe paraneoplastic gastroparesis associated with anti-Hu antibodies preceding the manifestation of small-cell lung cancer. (18322883)
2008
32
Simultaneous fundoplication and gastric stimulation in a lung transplant recipient with gastroparesis and reflux. (18765058)
2008
33
Gastroparesis--current concepts and considerations. (18324326)
2008
34
Mitemcinal (GM-611), an orally active motilin receptor agonist, improves delayed gastric emptying in a canine model of diabetic gastroparesis. (18346169)
2008
35
Gastroparesis associated with gastroesophageal reflux disease and corresponding reflux symptoms may be corrected by radiofrequency ablation of the cardia and esophagogastric junction. (18437485)
2008
36
Gastroparesis-related hospitalizations in the United States: trends, characteristics, and outcomes, 1995-2004. (18047541)
2008
37
Gastrointestinal electrical stimulation for treatment of gastrointestinal disorders: gastroparesis, obesity, fecal incontinence, and constipation. (17950445)
2007
38
Reversible gastroparesis: functional documentation of celiac axis compression syndrome and postoperative improvement. (16676860)
2006
39
Gastro-ileal stenosis and gastroparesis after a biliopancreatic diversion. (16989712)
2006
40
Diabetic gastroparesis. (16109013)
2005
41
New management approaches for gastroparesis. (16224477)
2005
42
Gastric stimulation is effective in reversing vasopressin induced gastroparesis. (16276827)
2004
43
Gastroparesis Cardinal Symptom Index (GCSI): development and validation of a patient reported assessment of severity of gastroparesis symptoms. (15129893)
2004
44
A systematic review of surgical therapy for gastroparesis. (14572555)
2003
45
Gastric neurostimulation for gastroparesis: time to pick up the pace. (12949743)
2003
46
The treatment of gastroparesis in the age of the gastric pacemaker: a review. (14745352)
2003
47
Treatment of gastroparesis with electrical stimulation. (12772777)
2003
48
Dyspepsia and gastroparesis in chronic renal failure: the role of Helicobacter pylori. (11924751)
2002
49
Gastric myoelectrical activity in patients with gastric outlet obstruction and idiopathic gastroparesis. (9772035)
1998
50
Evidence of impaired afferent vagal function in patients with diabetes gastroparesis. (1383975)
1992

Genetic Variations for Gastroparesis

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Expression for genes affiliated with Gastroparesis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gastroparesis

Search GEO for disease gene expression data for Gastroparesis.

Pathways for genes affiliated with Gastroparesis

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Sources:
53Reactome, 49PharmGKB, 29KEGG, 37NCBI BioSystems Database
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Compounds for genes affiliated with Gastroparesis

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Gastroparesis according to GeneCards/GeneDecks:

(show top 50)    (show all 141)
idCompoundScoreTop Affiliating Genes
1ranitidine44 28 11 2413.5CCK, MLN, SCT
2caerulein4410.5MLN, SCT, CCK
3pancreozymin4410.5GAST, SCT, CCK
4loxiglumide4410.5GAST, SCT, CCK
5lafutidine4410.5SCT, MLN, GAST
6glp-1 (7-36)amide4410.5SCT, GAST, GCG
7pepsinogen4410.4GAST, CCK, SCT
8peptone4410.4GCG, GAST, CCK
9rimonabant44 28 1112.4GCG, CCK, GHRL
10pramlintide44 1111.4CCK, GCG, GHRL
11pirenzepine44 28 1112.4GAST, GHRL, GCG, CCK
12ipamorelin4410.4GHSR, GHRL
13bethanechol44 28 1112.4GAST, MLN, GCG, CCK
14cisapride44 28 1112.4MLN, GCG, CCK, MLNR
15omeprazole44 28 49 11 2414.3CCK, SCT, GAST, MLN
16epft4410.3SCT, CCK
17norepinephrine44 11 2412.3ADRA1B, GAST, CCK, ADRA1D
18cyproheptadine28 44 1112.3ADRA1D, ADRA1B, CCK
19erythromycin44 49 2 1113.3GHRL, MLNR, MLN, GAST
20dtpa4410.3GAST, CCK, GCG
21c-peptide4410.3SCT, GCG, GHRL, GAST, CCK
22tetrodotoxin44 59 2812.3CCK, NOS1, MLN, SCT, GCG
23orlistat44 59 1112.3GHRL, GCG, CCK
24ondansetron44 49 11 2413.3MLN, GAST, CCK
25acetaminophen44 2 49 11 2414.3MLN, GAST, CCK, GCG, GHRL
26risperidone28 44 49 59 11 2415.2SCT, GHRL, ADRA1B, ADRA1D
27corticosterone44 59 2412.2NOS1, GAST, GCG, GHRL
28carbachol44 28 1112.2NOS1, CCK, GCG, GHRL, SCT, GAST
29acth4410.2CCK, GHSR, GAST, MLN, GHRL, SCT
30oxyntomodulin44 5911.2GAST, GCG, GHRL, SCT, CCK, MLN
31clozapine44 28 49 1113.2GHRL, NOS1, ADRA1B, ADRA1D
32gaba4410.2SCT, CCK, GAST, GHRL, NOS1, GCG
33ro-70-00042810.1ADRA1B, ADRA1D
34octreotide44 59 28 1113.1GHRL, GAST, SCT, CCK, GHSR, MLN
35atropine44 28 1112.1GHRL, MLN, GAST, SCT, CCK, GCG
36histamine44 28 2412.0GHRL, MLN, SCT, CCK, GAST, GCG
37nicardipine28 44 1112.0CCK, ADRA1B, ADRA1D
385-hydroxytryptamine4410.0GHRL, ADRA1B, NOS1, MLN, CCK, GCG
39epinephrine44 11 2412.0ADRA1B, GHRL, GAST, SCT, GCG, ADRA1D
40acetylcholine44 49 28 11 2413.9GHRL, GAST, HMOX2, SCT, CCK, GCG
41nitric oxide44 11 2411.9KCNE1, MRC1, MLN, GHSR, GHRL, HMOX2
42nifedipine44 49 28 1112.9GHRL, GCG, GAST, MLN
43arginine449.8GHSR, MLN, CCK, GCG, KCNE1, NOS1
44adenylate449.8NOS1, GHSR, KCNE1, GCG, CCK, SCT
455-methylurapidil289.8ADRA1D, ADRA1B
46glutamate449.8NOS1, HMOX2, ADRA1B, GAST, SCT, CCK
47glucose449.8GHSR, MLN, GAST, SCT, CCK, GHRL
48serine449.6SCT, GAST, MLN, GHSR, NOS1, GHRL
49dopamine44 28 11 2412.5ADRA1B, MLN, GCG, CCK, SCT, GAST
50calcium44 49 11 2412.3CCK, NOS1, GHSR, HMOX2, ADRA1D, ADRA1B

GO Terms for genes affiliated with Gastroparesis

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16Gene Ontology
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Cellular components related to Gastroparesis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:03477410.2GHRL, GCG

Biological processes related to Gastroparesis according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of appetiteGO:03210010.6GHSR, GHRL
2negative regulation of tumor necrosis factor biosynthetic processGO:04253610.6GHRL, GHSR
3regulation of delayed rectifier potassium channel activityGO:190225910.5KCNE2, KCNE1
4membrane repolarizationGO:08600910.5KCNE2, KCNE1
5negative regulation of interleukin-6 biosynthetic processGO:04540910.5GHSR, GHRL
6membrane repolarization involved in regulation of action potentialGO:08601110.5KCNE2, KCNE1
7negative regulation of interleukin-1 beta productionGO:03269110.5GHRL, GHSR
8regulation of potassium ion transmembrane transportGO:190137910.5KCNE1, KCNE2
9growth hormone secretionGO:03025210.5GHSR, GHRL
10potassium ion exportGO:07143510.4KCNE2, KCNE1
11adult feeding behaviorGO:00834310.4GHSR, GHRL
12regulation of cardiac muscle cell action potential involved in contractionGO:08600210.4KCNE1, KCNE2
13actin polymerization or depolymerizationGO:00815410.3GHRL, GHSR
14hormone-mediated signaling pathwayGO:00975510.3GHRL, GHSR
15regulation of ventricular cardiac muscle cell membrane repolarizationGO:06030710.2KCNE1, KCNE2
16regulation of cardiac muscle contractionGO:05511710.1NOS1, ADRA1B
17decidualizationGO:04669710.0GHRL, GHSR
18G-protein coupled receptor signaling pathwayGO:0071869.7ADRA1D, GCG, GAST, MLNR, MLN, GHSR

Molecular functions related to Gastroparesis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarizationGO:190228210.2KCNE2, KCNE1
2alpha1-adrenergic receptor activityGO:00493710.0ADRA1B, ADRA1D
3growth hormone-releasing hormone receptor activityGO:0165209.9GHSR, MLNR
4hormone activityGO:0051799.8MLN, GAST, SCT, CCK, GCG

Products for genes affiliated with Gastroparesis

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  • Antibodies
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Sources for Gastroparesis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet