MCID: GST037
MIFTS: 46

Gastroparesis malady

Gastrointestinal diseases category

Aliases & Classifications for Gastroparesis

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 38NCIt, 33MeSH, 55SNOMED-CT, 27ICD9CM
See all sources

Gastroparesis, Aliases & Descriptions:

Name: Gastroparesis 9 11 43 60
Gastroparesis Syndrome 9
 
Gastroparalysis 9
Gastric Atonia 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology9 DOID:11914
NCIt38 C80512
MeSH33 D018589
ICD9CM27 536.3

Summaries for Gastroparesis

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Wikipedia:63 Gastroparesis (gastro-, \"stomach\" + -paresis, \"partial paralysis\"), also called delayed gastric... more...

MalaCards based summary: Gastroparesis, also known as gastroparesis syndrome, is related to dyspepsia and morbid obesity. An important gene associated with Gastroparesis is GHRL (ghrelin/obestatin prepropeptide), and among its related pathways are Gastrin-CREB signalling pathway via PKC and MAPK and Peptide ligand-binding receptors. The drugs metoclopramide and cisapride and the compounds ipamorelin and ghrp-6 have been mentioned in the context of this disorder. Affiliated tissues include small intestine, lung and heart, and related mouse phenotypes are adipose tissue and behavior/neurological.

Related Diseases for Gastroparesis

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Diseases related to Gastroparesis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 90)
idRelated DiseaseScoreTop Affiliating Genes
1dyspepsia31.1CCK, GHRL
2morbid obesity30.5CCK, GHRL
3obesity30.1NOS1, GHSR, GHRL, CCK
4lung cancer30.0CCK, GHRL, NOS1
5pyloric stenosis10.4NOS1
6neuropathy10.3
7blindness10.3
8anorexia nervosa10.2GHRL, CCK
9growth hormone deficiency10.2GHSR, GHRL
10neuronitis10.2
11pancreatitis10.2
12bulimia nervosa10.2CCK, GHRL
13glucagonoma10.2GHRL, CCK
14gastrointestinal system disease10.2GHRL, CCK
15cushing's syndrome10.2GHRL, GHSR
16eating disorder10.2CCK, GHRL
17glucose intolerance10.2GHRL, CCK
18medullary thyroid carcinoma, familial10.2GHRL, CCK
19celiac disease10.2GHRL, CCK
20nutritional deficiency disease10.2CCK, GHRL
21pituitary tumors10.2GHSR, GHRL
22constipation10.2
23esophagitis10.2
24dysphagia10.2
25hypothyroidism10.2GHRL, GHSR
26gastritis10.2GHRL, CCK
27insulinoma10.1GHSR, GHRL
28alcohol dependence10.1GHRL, CCK
29ewing sarcoma10.1CCK, NOS1
30hirschsprung disease 110.1NOS1, HMOX2
31psychotic disorder10.1CCK, NOS1
32pancreatic cancer10.1
33cholangiocarcinoma10.1
34biliary dyskinesia10.1
35gastroduodenitis10.1
36atrial fibrillation10.1
37autonomic neuropathy10.1
38demyelinating disease10.1
39intestinal pseudo-obstruction10.1
40autonomic dysfunction10.1
41pituitary adenoma10.1GHSR, GHRL
42prader-willi syndrome10.0CCK, GHRL, GHSR
43acromegaly10.0GHSR, GHRL, CCK
44neuroendocrine tumor10.0CCK, GHRL, GHSR
45carcinoid syndrome10.0CCK, GHRL, GHSR
46hyperglycemia10.0CCK, GHRL, GHSR
47hyperinsulinism10.0GHRL, CCK
48vascular disease10.0NOS1, GHRL
49epilepsy syndrome10.0CCK, GHRL, NOS1
50cystic fibrosis9.9

Graphical network of the top 20 diseases related to Gastroparesis:



Diseases related to gastroparesis

Symptoms for Gastroparesis

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Drugs & Therapeutics for Gastroparesis

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Drug clinical trials:

Search ClinicalTrials for Gastroparesis

Search NIH Clinical Center for Gastroparesis

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Gastroparesis

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Anatomical Context for Gastroparesis

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MalaCards organs/tissues related to Gastroparesis:

31
Small intestine, Lung, Heart, Testes, Kidney, Pancreas, Bone marrow, Bone, Spinal cord

Animal Models for Gastroparesis or affiliated genes

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MGI Mouse Phenotypes related to Gastroparesis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.7GHRL, GHSR, NOS1
2MP:00053868.5NOS1, HMOX2, GHSR, GHRL
3MP:00053817.6NOS1, HMOX2, GHSR, GHRL, KCNE2
4MP:00053767.0KCNE2, CCK, GHRL, GHSR, HMOX2, NOS1

Publications for Gastroparesis

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Articles related to Gastroparesis:

(show top 50)    (show all 552)
idTitleAuthorsYear
1
Treatment of functional dyspepsia and gastroparesis. (25169218)
2014
2
SIBO in Gastroparesis: Sci-fi or Science Fact? (24435184)
2014
3
Curcumin improves expression of ghrelin through attenuating oxidative stress in gastric tissues of streptozotocin-induced diabetic gastroparesis rats. (24036253)
2013
4
Bodyweight in Patients with Idiopathic Gastroparesis: Roles of Symptoms, Caloric Intake, Physical Activity, and Body Metabolism. (24286121)
2013
5
Diagnostic assessment of diabetic gastroparesis. (23881199)
2013
6
Evaluation and Treatment of Gastric Stimulator Failure in Patients With Gastroparesis. (24056201)
2013
7
Minimally invasive surgical approach for the treatment of gastroparesis. (22752276)
2013
8
Through-the-scope transpyloric stent placement improves symptoms and gastric emptying in patients with gastroparesis. (23824975)
2013
9
Gastric electrical stimulation for treatment of clinically severe gastroparesis. (24250062)
2013
10
Gastric electrical stimulation for abdominal pain in patients with symptoms of gastroparesis. (23635579)
2013
11
Prevalence of gastroparesis before and after lung transplantation and its association with lung allograft outcomes. (22313020)
2012
12
Laparoscopic longitudinal gastrectomy and duodenojejunostomy for treatment of diabetic gastroparesis. (22963822)
2012
13
Prevalence of hidden gastroparesis in the community: the gastroparesis "iceberg". (22323986)
2012
14
Oxytocin prolongs the gastric emptying time in patients with diabetes mellitus and gastroparesis, but does not affect satiety or volume intake in patients with functional dyspepsia. (22420866)
2012
15
Spectrum of gastroparesis in children. (22314391)
2012
16
Platelet-derived growth factor receptor I+ (PDGFRI+)-expressing "fibroblast-like cells" in diabetic and idiopathic gastroparesis of humans. (22650155)
2012
17
Two-channel gastric pacing in patients with diabetic gastroparesis. (21806741)
2011
18
Bloating in gastroparesis: severity, impact, and associated factors. (21483459)
2011
19
Clinical features of idiopathic gastroparesis vary with sex, body mass, symptom onset, delay in gastric emptying, and gastroparesis severity. (20965184)
2011
20
Severe gastroparesis: medical therapy or gastric electrical stimulation. (19765675)
2010
21
Prevalence of gastroparesis in type 1 diabetes mellitus and its relationship to dyspeptic symptoms. (20922192)
2010
22
Advantages of azithromycin over erythromycin in improving the gastric emptying half-time in adult patients with gastroparesis. (21103422)
2010
23
Diabetic gastroparesis: Therapeutic options. (22127672)
2010
24
Delayed radionucleotide gastric emptying studies predict morbidity in diabetics with symptoms of gastroparesis. (19410575)
2009
25
Methods of gastric electrical stimulation and pacing: a review of their benefits and mechanisms of action in gastroparesis and obesity. (19254353)
2009
26
Gastroparesis: current concepts and management. (20431741)
2009
27
Factors associated with symptom response to pyloric injection of botulinum toxin in a large series of gastroparesis patients. (19184429)
2009
28
Gastroparesis associated with high-dose cytosine arabinoside. (18290834)
2008
29
A case report of gastroparesis secondary to acute renal failure. (19024208)
2008
30
Severe paraneoplastic gastroparesis associated with anti-Hu antibodies preceding the manifestation of small-cell lung cancer. (18322883)
2008
31
Simultaneous fundoplication and gastric stimulation in a lung transplant recipient with gastroparesis and reflux. (18765058)
2008
32
Treatment options for patients with severe gastroparesis. (17519490)
2007
33
Gastroparesis in multiple sclerosis. (17548454)
2007
34
Gastroparesis secondary to a demyelinating disease: a case series. (17266755)
2007
35
Overcoming diabetic gastroparesis en route to kidney transplant. (16640536)
2006
36
Mirtazapine for severe gastroparesis unresponsive to conventional prokinetic treatment. (16959934)
2006
37
Treating gastroparesis. (17022124)
2006
38
Severe isolated myopathic gastroparesis: a case report with pathological findings. (17047114)
2006
39
Symptom responses, long-term outcomes and adverse events beyond 3 years of high-frequency gastric electrical stimulation for gastroparesis. (16371079)
2006
40
Relief of acute pain in chronic idiopathic gastroparesis with intravenous phentolamine. (17003080)
2006
41
Gastroparesis after a pylorus-preserving pancreatoduodenectomy. (15864414)
2005
42
Influence of ghrelin on gastric emptying and meal-related symptoms in idiopathic gastroparesis. (16225494)
2005
43
Acute gastroparesis secondary to gastric emphysema: a rare complication of balloon dilation. (15472708)
2004
44
Treatment of Gastroparesis. (15010028)
2004
45
Clinical observation on acupuncture treatment in 35 cases of diabetic gastroparesis. (15510787)
2004
46
A systematic review of surgical therapy for gastroparesis. (14572555)
2003
47
Methods for treating diabetic gastroparesis. (11984224)
2002
48
Advances in diabetic gastroparesis. (12122960)
2002
49
Effects of fedotozine on gastric emptying and upper gastrointestinal symptoms in diabetic gastroparesis. (10886051)
2000
50
The effect of chronic oral domperidone therapy on gastrointestinal symptoms, gastric emptying, and quality of life in patients with gastroparesis. (9177513)
1997

Variations for Gastroparesis

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Expression for genes affiliated with Gastroparesis

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Search GEO for disease gene expression data for Gastroparesis.

Pathways for genes affiliated with Gastroparesis

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Compounds for genes affiliated with Gastroparesis

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Compounds related to Gastroparesis according to GeneCards Suite gene sharing:

(show top 50)    (show all 58)
idCompoundScoreTop Affiliating Genes
1ipamorelin4310.1GHSR, GHRL
2ghrp-628 4311.1GHSR, GHRL
3ghrp4310.0GHRL, GHSR
4hexarelin43 2811.0GHSR, GHRL
5decanoic acid43 28 1212.0CCK, GHRL
6octadecaneuropeptide4310.0CCK, GHRL
7rimonabant43 28 1211.9CCK, GHRL
8pramlintide43 1210.9GHRL, CCK
9vapreotide43 28 1211.9GHSR, CCK
10intralipid439.9CCK, GHRL
11pirenzepine43 28 1211.9CCK, GHRL
12oxyntomodulin43 5910.9GHRL, CCK
13orlistat43 59 1211.9GHRL, CCK
14naloxone43 28 49 1212.8CCK, GHRL
15amphetamine43 49 1211.8GHRL, CCK
16lactose43 1210.8GHRL, CCK
17c-peptide439.7CCK, GHRL
18zinc protoporphyrin439.7NOS1, HMOX2
19opiate439.7GHRL, CCK
20capsaicin43 2810.7NOS1, GHRL
21amide439.7GHRL, CCK
22acetaminophen43 2 49 24 1213.6CCK, GHRL
23octreotide43 59 28 1212.5GHSR, GHRL, CCK
24tetrodotoxin43 59 2811.5NOS1, CCK
25acth439.5CCK, GHRL, GHSR
26corticosterone43 59 2411.4NOS1, GHRL
27ribonucleic acid439.4HMOX2, GHSR, GHRL
28forskolin43 49 1211.4GHSR, GHRL, CCK
29l-nmma439.4CCK, GHRL, NOS1
30atropine43 28 1211.4CCK, GHRL, NOS1
31cocaine43 1210.3NOS1, GHRL, CCK
32clozapine43 28 49 1212.3NOS1, GHRL
33carbachol43 28 1211.3NOS1, GHRL, CCK
345-hydroxytryptamine439.3CCK, GHRL, NOS1
35sodium nitroprusside439.3NOS1, CCK
36gaba439.3CCK, GHRL, NOS1
37norepinephrine43 24 1211.2CCK, GHRL, NOS1
38histamine43 28 2411.2NOS1, GHRL, CCK
39carbon439.2NOS1, HMOX2, CCK
40morphine43 49 28 1212.0NOS1, CCK
41adenylate438.9NOS1, GHSR, GHRL, CCK
42glucose438.9CCK, GHRL, GHSR, HMOX2
43testosterone43 59 24 1211.9CCK, GHRL, GHSR, NOS1
44dexamethasone43 49 28 1211.9CCK, GHRL, GHSR, NOS1
45nitric oxide43 24 1210.9NOS1, HMOX2, GHSR, GHRL
46acetylcholine43 49 28 24 1212.8NOS1, HMOX2, GHRL, CCK
47estrogen438.8NOS1, HMOX2, GHSR, GHRL
48glutamate438.8CCK, GHRL, HMOX2, NOS1
49dopamine43 28 24 1211.4NOS1, HMOX2, GHSR, GHRL, CCK
50arginine438.4CCK, GHRL, GHSR, HMOX2, NOS1

GO Terms for genes affiliated with Gastroparesis

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Cellular components related to Gastroparesis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1axonGO:00304249.5GHRL, CCK

Biological processes related to Gastroparesis according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of appetiteGO:00321009.9GHSR, GHRL
2negative regulation of tumor necrosis factor biosynthetic processGO:00425369.9GHSR, GHRL
3negative regulation of interleukin-6 biosynthetic processGO:00454099.9GHSR, GHRL
4negative regulation of interleukin-1 beta productionGO:00326919.9GHRL, GHSR
5growth hormone secretionGO:00302529.8GHRL, GHSR
6adult feeding behaviorGO:00083439.8GHSR, GHRL
7actin polymerization or depolymerizationGO:00081549.8GHSR, GHRL
8decidualizationGO:00466979.8GHRL, GHSR
9hormone-mediated signaling pathwayGO:00097559.7GHSR, GHRL
10negative regulation of insulin secretionGO:00466769.7GHSR, GHRL
11positive regulation of multicellular organism growthGO:00400189.6GHRL, GHSR
12response to hormoneGO:00097259.5GHSR, GHRL
13response to hypoxiaGO:00016669.3NOS1, HMOX2
14negative regulation of inflammatory responseGO:00507289.3GHSR, GHRL

Molecular functions related to Gastroparesis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ion channel bindingGO:00443259.0NOS1, KCNE2

Products for genes affiliated with Gastroparesis

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Sources for Gastroparesis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet