MCID: GST037
MIFTS: 54

Gastroparesis malady

Gastrointestinal category

Summaries for Gastroparesis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Gastroparesis (gastro-, \"stomach\" + -paresis, \"partial paralysis\"), also called delayed gastric... more...

MalaCards: Gastroparesis, also known as gastroparesis syndrome, is related to dyspepsia and morbid obesity. An important gene associated with Gastroparesis is GHRL (ghrelin/obestatin prepropeptide), and among its related pathways are Cell death signalling via NRAGE, NRIF and NADE and Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1). The drugs metoclopramide and cisapride and the compounds ranitidine and caerulein have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, spinal cord and heart, and related mouse phenotypes are adipose tissue and digestive/alimentary.

Aliases & Classifications for Gastroparesis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 27ICD9CM, 57SNOMED-CT, 40NCIt, 35MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal


Aliases & Descriptions:

gastroparesis 8 10 45 61
gastroparesis syndrome 8
gastroparalysis 8
gastric atonia 8


External Ids:

Disease Ontology8 DOID:11914
ICD9CM27 536.3
NCIt40 C80512
MeSH35 D018589

Related Diseases for Gastroparesis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Gastroparesis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 88)
idRelated DiseaseScoreTop Affiliating Genes
1dyspepsia30.7CCK, GAST, MLNR, MLN, GHRL, SPAG7
2morbid obesity30.1GCG, CCK, GHRL
3autonomic neuropathy30.1MLN, GAST, CCK, GCG
4diabetic autonomic neuropathy29.9MLNR
5gastric outlet obstruction29.9GAST, MLN
6cystic fibrosis29.9SCT
7duodenogastric reflux29.9MLN, GAST, CCK
8pancreatitis, chronic29.9GCG, CCK, SCT
9gastroesophageal reflux disease29.9GCG, CCK, SCT, GAST, MLN
10chronic pain10.2
11parkinson's disease10.2
12dysphagia10.2
13autonomic dysfunction10.1
14gastroduodenitis10.0GAST
15neuroendocrine tumor10.0GCG
16duodenitis10.0GAST
17multiple endocrine neoplasia10.0GAST
18esophagitis10.0GAST
19postcholecystectomy syndrome10.0GAST
20irritable bowel syndrome10.0MLN, CCK
21pyloric stenosis10.0NOS1, GAST
22dumping syndrome10.0MLN, GCG
23pituitary adenoma10.0GHSR, GHRL
24constipation10.0MLN, CCK
25ileus10.0MLNR, MLN, GHRL
26hyperparathyroidism10.0SCT, GAST
27liver cirrhosis10.0MLN, SCT
28zollinger-ellison syndrome10.0SCT, GAST
29bile reflux10.0CCK
30acromegaly10.0CCK, GHSR, GHRL
31anorexia nervosa10.0GHRL, CCK, GCG
32gallbladder disease10.0CCK, MLNR, MLN
33diarrhea10.0GCG, GAST, MLN
34eating disorder10.0GHRL
35bulimia nervosa10.0CCK, GHRL
36peptic ulcer10.0CCK, SCT, GAST
37steatorrhea10.0SCT, CCK, GCG
38hyperinsulinemic hypoglycemia10.0SCT, GAST
39long qt syndrome 110.0KCNE2, KCNE1
40acute pancreatitis10.0SCT, CCK
41atrophic gastritis10.0GHRL, GAST, SCT
42thyroid medullary carcinoma10.0GHRL, GAST, CCK
43gastritis10.0SCT, GAST, GHRL
44prader-willi syndrome10.0CCK, GHSR, GHRL
45short bowel syndrome10.0GCG, CCK, GAST
46long qt syndrome10.0KCNE2, KCNE1
47wermer syndrome10.0GHRL, GAST, SCT
48myocardial infarction10.0GCG, GHRL, NOS1
49gastrinoma10.0GAST, SCT, GCG
50somatostatinoma10.0GAST

Graphical network of the top 20 diseases related to Gastroparesis:



Diseases related to gastroparesis

Clinical Features for Gastroparesis

Drugs & Therapeutics for Gastroparesis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Gastroparesis

Drug clinical trials:

Search ClinicalTrials for Gastroparesis

Search NIH Clinical Center for Gastroparesis

Search CenterWatch for Gastroparesis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Gastroparesis

Anatomical Context for Gastroparesis

Sources:
33MalaCards
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MalaCards organs/tissues related to Gastroparesis:

33
Bone marrow, Spinal cord, Heart, Smooth muscle, Small intestine, Kidney, Lung, Pancreas

Animal Models for Gastroparesis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Gastroparesis

Sources:
51PubMed
See all sources

Articles related to Gastroparesis:

(show top 50)    (show all 509)
idTitleAuthorsYear
1
SIBO in Gastroparesis: Sci-fi or Science Fact? (24435184)
2014
2
Diagnostic assessment of diabetic gastroparesis. (23881199)
2013
3
Incidence and risk factors for postsurgical gastroparesis syndrome after laparoscopic and open radical gastrectomy. (23782501)
2013
4
Gastric electrical stimulation with Enterra therapy improves symptoms of idiopathic gastroparesis. (23895180)
2013
5
Glucose-induced incretin hormone release and insulin sensitivity are impaired in patients with idiopathic gastroparesis: results from a pilot descriptive study. (23663508)
2013
6
Gastroparesis: from concepts to management. (23797376)
2013
7
Prevalence of gastroparesis before and after lung transplantation and its association with lung allograft outcomes. (22313020)
2012
8
Gastric electrical stimulation for the treatment of diabetic gastroparesis. (22742875)
2012
9
Motility: Mapping gastric dysrhythmias in gastroparesis--a slow wave of electrical activity. (22710570)
2012
10
Profound gastroparesis after bilateral posterior inferior cerebellar artery territory infarcts. (22257518)
2012
11
Similarities and differences between diabetic and idiopathic gastroparesis. (21871247)
2011
12
National survey of physicians' perception of the cause, complications, and management of gastroparesis. (21886030)
2011
13
Gender bias in gastroparesis: is nitric oxide the answer? (21559738)
2011
14
Continuous glucose monitoring in gastroparesis. (21735078)
2011
15
Variation of symptoms during the menstrual cycle in female patients with gastroparesis. (21332597)
2011
16
Gastric emptying of solids and liquids for evaluation for gastroparesis. (21365240)
2011
17
Pharmacotherapy for gastroparesis: an attempt to evaluate a safer alternative. (21103416)
2010
18
The incidence, prevalence, and survival of gastroparesis in olmsted county, Minnesota, 1996-2006 (gastroenterology 2009;136:1225-1233). (20535336)
2010
19
Gastroparesis and functional dyspepsia: excerpts from the AGA/ANMS meeting. (20003077)
2010
20
The assessment of regional gut transit times in healthy controls and patients with gastroparesis using wireless motility technology. (19814743)
2010
21
Safety and efficacy of ghrelin agonist TZP-101 in relieving symptoms in patients with diabetic gastroparesis: a randomized, placebo-controlled study. (20524987)
2010
22
Endoscopic pyloric injection of botulinum toxin-A for the treatment of postvagotomy gastroparesis. (19174691)
2009
23
Gastroparesis associated with gastroptosis presenting as a lower abdominal bulking mass in a child: a case report. (19946494)
2009
24
Pharmacotherapy of gastroparesis. (19191682)
2009
25
Quality of life and symptomatic response to gastric neurostimulation for gastroparesis. (18712572)
2008
26
A single-blinded, randomized pilot study evaluating effects of electroacupuncture in diabetic patients with symptoms suggestive of gastroparesis. (18721079)
2008
27
To clot or not to clot: are there predictors of clinically significant thrombus formation in patients with gastroparesis and prolonged IV access? (17990116)
2008
28
Full-thickness endoscopic sampling of the stomach wall as a technique to manage gastroparesis. (18656598)
2008
29
Itopride and pantoprazole outcomes in diabetic gastroparesis trial (IPOD trial). (19370958)
2008
30
Gastroparesis in multiple sclerosis. (17548454)
2007
31
Botulinum toxin type A for treatment of refractory gastroparesis. (17959574)
2007
32
Diabetic gastroparesis. (17663031)
2007
33
Overcoming diabetic gastroparesis en route to kidney transplant. (16640536)
2006
34
Severe isolated myopathic gastroparesis: a case report with pathological findings. (17047114)
2006
35
Gastroparesis: clinical update. (16696789)
2006
36
Gastroparesis refractory to prokinetics: neuromuscolar unresponsiveness or faulty bioavailability of the drug? (15906763)
2005
37
Gastroparesis. An electrical cure? Research profile. Richard McCallum, MD. (16294414)
2005
38
Ghrelin enhances gastric emptying in diabetic gastroparesis: a double blind, placebo controlled, crossover study. (16085693)
2005
39
Gastroparesis in diabetes mellitus: an ultrasonographic study. (15800688)
2005
40
Gastric electrical stimulation: a novel treatment for gastroparesis. (16121891)
2005
41
Pilot study on gastric electrical stimulation on surgery-associated gastroparesis: long-term outcome. (16108237)
2005
42
Effect of the motilin agonist KC 11458 on gastric emptying in diabetic gastroparesis. (15274670)
2004
43
Vomiting and gastroparesis in thoracic myelopathy with pure sympathetic dysfunction. (15448436)
2004
44
American Gastroenterological Association technical review on the diagnosis and treatment of gastroparesis. (15521026)
2004
45
Severe idiopathic gastroparesis due to neuronal and interstitial cells of Cajal degeneration: pathological findings and management. (12801952)
2003
46
Diabetic gastroparesis improved by percutaneous endoscopic jejunostomy. (10868883)
2000
47
Pharmacotherapy of gastroparesis. (11249497)
2000
48
Comparison of metoclopramide and erythromycin in the treatment of diabetic gastroparesis. (8299441)
1993
49
Diabetic gastroparesis. A critical reappraisal of new treatment strategies. (1281070)
1992
50
Aspiration pneumonitis following electroconvulsive therapy in patients with gastroparesis. (3228567)
1988

Genetic Variations for Gastroparesis

Expression for genes affiliated with Gastroparesis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Gastroparesis

Search GEO for disease gene expression data for Gastroparesis.

Pathways for genes affiliated with Gastroparesis

Sources:
54Reactome, 50PharmGKB, 30KEGG, 38NCBI BioSystems Database
See all sources

Compounds for genes affiliated with Gastroparesis

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 2BitterDB, 60Tocris Bioscience
See all sources

Compounds related to Gastroparesis according to GeneCards/GeneDecks:

(show top 50)    (show all 141)
idCompoundScoreTop Affiliating Genes
1ranitidine45 29 11 2413.5CCK, MLN, SCT
2caerulein4510.5MLN, SCT, CCK
3pancreozymin4510.5GAST, SCT, CCK
4loxiglumide4510.5GAST, SCT, CCK
5lafutidine4510.5SCT, MLN, GAST
6glp-1 (7-36)amide4510.5SCT, GAST, GCG
7pepsinogen4510.4SCT, CCK, GAST
8peptone4510.4GCG, GAST, CCK
9rimonabant45 29 1112.4GHRL, GCG, CCK
10pramlintide45 1111.4GHRL, GCG, CCK
11pirenzepine45 29 1112.4GAST, GHRL, GCG, CCK
12ipamorelin4510.4GHSR, GHRL
13bethanechol45 29 1112.4GAST, MLN, GCG, CCK
14cisapride45 29 1112.4MLN, GCG, CCK, MLNR
15omeprazole45 29 50 11 2414.3CCK, SCT, GAST, MLN
16epft4510.3SCT, CCK
17norepinephrine45 11 2412.3ADRA1B, GAST, CCK, ADRA1D
18cyproheptadine29 45 1112.3ADRA1B, CCK, ADRA1D
19erythromycin45 50 2 1113.3MLNR, GAST, GHRL, MLN
20dtpa4510.3GAST, CCK, GCG
21c-peptide4510.3SCT, GCG, GHRL, GAST, CCK
22tetrodotoxin45 60 2912.3CCK, NOS1, MLN, SCT, GCG
23orlistat45 60 1112.3GHRL, GCG, CCK
24ondansetron45 50 11 2413.3MLN, GAST, CCK
25acetaminophen45 2 50 11 2414.3MLN, GAST, CCK, GCG, GHRL
26risperidone29 45 50 60 11 2415.2SCT, GHRL, ADRA1B, ADRA1D
27corticosterone45 60 2412.2NOS1, GAST, GCG, GHRL
28carbachol45 29 1112.2NOS1, CCK, GCG, GHRL, SCT, GAST
29acth4510.2CCK, GHSR, GAST, MLN, GHRL, SCT
30oxyntomodulin45 6011.2GAST, GCG, GHRL, SCT, CCK, MLN
31clozapine45 29 50 1113.2GHRL, NOS1, ADRA1B, ADRA1D
32gaba4510.2SCT, CCK, GAST, GHRL, NOS1, GCG
33(+)-adrenaline2910.1ADRA1B, ADRA1D
34octreotide45 60 29 1113.1GHRL, GAST, SCT, CCK, GHSR, MLN
35atropine45 29 1112.1GHRL, MLN, GAST, SCT, CCK, GCG
36histamine45 29 2412.0GHRL, MLN, SCT, CCK, GAST, GCG
37nicardipine29 45 1112.0CCK, ADRA1B, ADRA1D
385-hydroxytryptamine4510.0GHRL, ADRA1B, NOS1, MLN, CCK, GCG
39epinephrine45 11 2412.0ADRA1B, GHRL, GAST, SCT, GCG, ADRA1D
40acetylcholine45 50 29 11 2413.9GHRL, GAST, HMOX2, SCT, CCK, GCG
41nitric oxide45 11 2411.9KCNE1, MRC1, MLN, GHSR, GHRL, HMOX2
42nifedipine45 50 29 1112.9GHRL, GCG, GAST, MLN
43arginine459.8GHSR, MLN, CCK, GCG, KCNE1, NOS1
44adenylate459.8NOS1, GHSR, KCNE1, GCG, CCK, SCT
45[125i]heat299.8ADRA1D, ADRA1B
46glutamate459.8NOS1, HMOX2, ADRA1B, GAST, SCT, CCK
47glucose459.8GHRL, GHSR, MLN, GAST, SCT, CCK
48serine459.6SCT, GAST, MLN, GHSR, NOS1, GHRL
49dopamine45 29 11 2412.5ADRA1B, MLN, GCG, CCK, SCT, GAST
50calcium45 50 11 2412.3ADRA1B, ADRA1D, NOS1, HMOX2, GHSR, CCK

GO Terms for genes affiliated with Gastroparesis

Sources:
16Gene Ontology
See all sources

Cellular components related to Gastroparesis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:03477410.2GHRL, GCG

Biological processes related to Gastroparesis according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of appetiteGO:03210010.6GHSR, GHRL
2negative regulation of tumor necrosis factor biosynthetic processGO:04253610.6GHRL, GHSR
3regulation of delayed rectifier potassium channel activityGO:190225910.5KCNE2, KCNE1
4membrane repolarizationGO:08600910.5KCNE2, KCNE1
5negative regulation of interleukin-6 biosynthetic processGO:04540910.5GHSR, GHRL
6membrane repolarization involved in regulation of action potentialGO:08601110.5KCNE2, KCNE1
7negative regulation of interleukin-1 beta productionGO:03269110.5GHRL, GHSR
8regulation of potassium ion transmembrane transportGO:190137910.5KCNE1, KCNE2
9growth hormone secretionGO:03025210.5GHSR, GHRL
10potassium ion exportGO:07143510.4KCNE2, KCNE1
11adult feeding behaviorGO:00834310.4GHSR, GHRL
12regulation of cardiac muscle cell action potential involved in contractionGO:08600210.4KCNE1, KCNE2
13actin polymerization or depolymerizationGO:00815410.3GHRL, GHSR
14hormone-mediated signaling pathwayGO:00975510.3GHRL, GHSR
15regulation of ventricular cardiac muscle cell membrane repolarizationGO:06030710.2KCNE1, KCNE2
16regulation of cardiac muscle contractionGO:05511710.1NOS1, ADRA1B
17decidualizationGO:04669710.0GHRL, GHSR
18G-protein coupled receptor signaling pathwayGO:0071869.7ADRA1D, GCG, GAST, MLNR, MLN, GHSR

Molecular functions related to Gastroparesis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarizationGO:190228210.2KCNE2, KCNE1
2alpha1-adrenergic receptor activityGO:00493710.0ADRA1D, ADRA1B
3growth hormone-releasing hormone receptor activityGO:0165209.9GHSR, MLNR
4hormone activityGO:0051799.8CCK, GCG, MLN, GAST, SCT

Products for genes affiliated with Gastroparesis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gastroparesis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet