MCID: GST037
MIFTS: 57

Gastroparesis malady

Gastrointestinal diseases category

Summaries for Gastroparesis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Gastroparesis (gastro-, \"stomach\" + -paresis, \"partial paralysis\"), also called delayed gastric... more...

MalaCards: Gastroparesis, also known as gastroparesis syndrome, is related to dyspepsia and diabetes mellitus. An important gene associated with Gastroparesis is GHRL (ghrelin/obestatin prepropeptide), and among its related pathways are Cell death signalling via NRAGE, NRIF and NADE and Insulin Processing. The drugs metoclopramide and cisapride and the compounds ranitidine and caerulein have been mentioned in the context of this disorder. Affiliated tissues include small intestine, lung and heart, and related mouse phenotypes are adipose tissue and digestive/alimentary.

Aliases & Classifications for Gastroparesis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 39NCIt, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

gastroparesis 8 10 44 60
gastroparesis syndrome 8
gastroparalysis 8
gastric atonia 8


External Ids:

Disease Ontology8 DOID:11914
ICD9CM27 536.3
NCIt39 C80512
MeSH34 D018589

Related Diseases for Gastroparesis

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17GeneCards, 18GeneDecks
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Diseases related to Gastroparesis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 102)
idRelated DiseaseScoreTop Affiliating Genes
1dyspepsia30.6CCK, GAST, MLNR, MLN, GHRL, SPAG7
2diabetes mellitus30.5GHRL, MLN, SCT, CCK, GCG
3obesity30.3GCG, CCK, MLN, GHSR, GHRL, NOS1
4pancreatitis30.2GCG, CCK, SCT
5esophagitis30.2GAST
6constipation30.2MLN, CCK
7gastroduodenitis30.0GAST
8morbid obesity30.0GCG, CCK, GHRL
9autonomic neuropathy30.0MLN, GAST, CCK, GCG
10pancreatic cancer30.0GAST, SCT, CCK, GCG
11diabetic autonomic neuropathy29.8MLNR
12cystic fibrosis29.8SCT
13duodenogastric reflux29.8MLN, GAST, CCK
14gallbladder disease29.8CCK, MLNR, MLN
15gastroesophageal reflux disease29.8GCG, CCK, SCT, GAST, MLN
16type 2 diabetes mellitus29.8GHRL, SCT, CCK, GCG
17neuropathy10.3
18parkinson's disease10.2
19neuronitis10.2
20diabetic neuropathy10.2
21lung cancer10.2
22type 1 diabetes mellitus10.1
23gastric dilatation10.0
24cholangiocarcinoma10.0
25intestinal obstruction10.0
26intestinal pseudo-obstruction10.0
27multiple sclerosis10.0
28neuroendocrine tumor10.0GCG
29duodenitis10.0GAST
30multiple endocrine neoplasia10.0GAST
31postcholecystectomy syndrome10.0GAST
32gastric outlet obstruction10.0GAST, MLN
33irritable bowel syndrome10.0MLN, CCK
34pyloric stenosis10.0NOS1, GAST
35dumping syndrome10.0MLN, GCG
36pituitary adenoma10.0GHSR, GHRL
37ileus10.0MLNR, MLN, GHRL
38hyperparathyroidism10.0SCT, GAST
39liver cirrhosis10.0MLN, SCT
40zollinger-ellison syndrome10.0SCT, GAST
41bile reflux10.0CCK
42acromegaly10.0CCK, GHSR, GHRL
43anorexia nervosa10.0GHRL, CCK, GCG
44diarrhea10.0GCG, GAST, MLN
45eating disorder10.0GHRL
46bulimia nervosa10.0CCK, GHRL
47peptic ulcer10.0CCK, SCT, GAST
48steatorrhea10.0SCT, CCK, GCG
49hyperinsulinemic hypoglycemia10.0SCT, GAST
50long qt syndrome 110.0KCNE2, KCNE1

Graphical network of the top 20 diseases related to Gastroparesis:



Diseases related to gastroparesis

Clinical Features for Gastroparesis

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Drugs & Therapeutics for Gastroparesis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Gastroparesis

Drug clinical trials:

Search ClinicalTrials for Gastroparesis

Search NIH Clinical Center for Gastroparesis

Search CenterWatch for Gastroparesis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Gastroparesis

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Anatomical Context for Gastroparesis

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32MalaCards
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MalaCards organs/tissues related to Gastroparesis:

32
Small intestine, Lung, Heart, Testes, Kidney, Pancreas, Bone marrow, Bone, Spinal cord

Animal Models for Gastroparesis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Gastroparesis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.8ADRA1B, NOS1, GHRL, GHSR, MBOAT4
2MP:00053819.6KCNE1, KCNE2, GAST, GHSR, GHRL, HMOX2
3MP:00053869.0KCNE1, MBOAT4, SCT, GHSR, GHRL, HMOX2
4MP:00053768.8ADRA1B, KCNE1, KCNE2, GCG, CCK, MRC1

Publications for Gastroparesis

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50PubMed
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Articles related to Gastroparesis:

(show top 50)    (show all 509)
idTitleAuthorsYear
1
The role of the vagal pathway and gastric dopamine in the gastroparesis of rats after a 6-hydroxydopamine microinjection in the substantia nigra. (24410908)
2014
2
Gastric electrical stimulation for treatment of clinically severe gastroparesis. (24250062)
2013
3
Gastric electrical stimulation for abdominal pain in patients with symptoms of gastroparesis. (23635579)
2013
4
Chronic estrogen deficiency causes gastroparesis by altering neuronal nitric oxide synthase function. (23504347)
2013
5
Regional differences in healthcare delivery for gastroparesis. (23525736)
2013
6
The relation between symptom improvement and gastric emptying in the treatment of diabetic and idiopathic gastroparesis. (24005344)
2013
7
A Case of Extreme Gastroparesis due to an Occult Small Cell Cancer of the Lung. (24368948)
2013
8
Novel soy germ pasta enriched in isoflavones ameliorates gastroparesis in type 2 diabetes: a pilot study. (23835688)
2013
9
Azithromycin for the treatment of gastroparesis. (23447477)
2013
10
Factors related to abdominal pain in gastroparesis: contrast to patients with predominant nausea and vomiting. (23414452)
2013
11
Laparoscopic gastric electrical stimulation for medically refractory diabetic and idiopathic gastroparesis. (23288718)
2013
12
Evaluating symptom outcomes in gastroparesis clinical trials: validity and responsiveness of the Gastroparesis Cardinal Symptom Index-Daily Diary (GCSI-DD). (22284754)
2012
13
Gastroparesis and Parkinson's disease: a systematic review. (22209346)
2012
14
Diabetic gastroparesis: pathophysiology, evaluation and management. (22875523)
2012
15
Effect of mosapride citrate on gastric emptying in interferon-induced gastroparesis. (22399248)
2012
16
Treatment of high-frequency gastric electrical stimulation for gastroparesis. (22128901)
2012
17
Nausea and vomiting in diabetic and idiopathic gastroparesis. (22118574)
2012
18
Prokinetics in diabetic gastroparesis. (22688694)
2012
19
Functional dyspepsia and gastroparesis: one disease or two? (23160285)
2012
20
Clinical features of idiopathic gastroparesis vary with sex, body mass, symptom onset, delay in gastric emptying, and gastroparesis severity. (20965184)
2011
21
Obesity and symptoms suggestive of gastroparesis in patients with type 2 diabetes and neuropathy. (21813291)
2011
22
Video: temporary gastric electrical stimulation for gastroparesis: endoscopic placement of electrodes (ENDOstim). (21556999)
2011
23
Dietary intake and nutritional deficiencies in patients with diabetic or idiopathic gastroparesis. (21684286)
2011
24
Diabetic gastroparesis-backwards and forwards. (21199514)
2011
25
Severe gastroparesis: medical therapy or gastric electrical stimulation. (19765675)
2010
26
Gastric electrical stimulation with Enterra therapy improves symptoms from diabetic gastroparesis in a prospective study. (20538073)
2010
27
Acute reversible gastroparesis and megaduodenum after botulinum toxin injection for achalasia. (20304403)
2010
28
Factors associated with symptom response to pyloric injection of botulinum toxin in a large series of gastroparesis patients. (19184429)
2009
29
The incidence, prevalence, and outcomes of patients with gastroparesis in Olmsted County, Minnesota, from 1996 to 2006. (19249393)
2009
30
High-frequency gastric electrical stimulation for the treatment of gastroparesis: a meta-analysis. (19506941)
2009
31
Clinical effects of STW 5 (Iberogast) are not based on acceleration of gastric emptying in patients with functional dyspepsia and gastroparesis. (19220753)
2009
32
Gastroparesis, pseudoachalasia and impaired intestinal motility as paraneoplastic manifestations of small cell lung cancer. (19506460)
2009
33
Heme oxygenase-1 protects interstitial cells of Cajal from oxidative stress and reverses diabetic gastroparesis. (18926825)
2008
34
A systematic review of the efficacy of domperidone for the treatment of diabetic gastroparesis. (18524689)
2008
35
Is gastric electrical stimulation an effective therapy for patients with drug-refractory gastroparesis? (18542114)
2008
36
Gastroparesis in patients with inactive Crohn's disease: a case series. (17376243)
2007
37
Gastroparesis in type 2 diabetes mellitus: prevalence, etiology, diagnosis, and treatment. (17883973)
2007
38
Treating gastroparesis. (17022124)
2006
39
Update on gastroparesis. (16770141)
2006
40
Management of diabetic gastroparesis. (16173296)
2005
41
Acute gastroparesis secondary to gastric emphysema: a rare complication of balloon dilation. (15472708)
2004
42
Gastric pacing for severe gastroparesis in a heart-lung transplant recipient. (15019648)
2004
43
Current pharmacological treatment of gastroparesis. (15500371)
2004
44
Gastric electrical stimulation for medically refractory gastroparesis. (12891544)
2003
45
Gastric electrical stimulation for gastroparesis improves nutritional parameters at short, intermediate, and long-term follow-up. (12903891)
2003
46
Gastroparesis. A case of unexplained lows. (15317086)
2003
47
Enterra for gastroparesis. (14638376)
2003
48
Gastroparesis and its management. (12092172)
2001
49
Gastroparesis following bone marrow transplantation. (11498745)
2001
50
Extreme but asymptomatic hypergastrinemia with gastroparesis in a young woman with insulin dependent diabetes mellitus. (9648055)
1998

Genetic Variations for Gastroparesis

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Expression for genes affiliated with Gastroparesis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gastroparesis

Search GEO for disease gene expression data for Gastroparesis.

Pathways for genes affiliated with Gastroparesis

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Sources:
53Reactome, 49PharmGKB, 29KEGG, 37NCBI BioSystems Database
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Compounds for genes affiliated with Gastroparesis

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Gastroparesis according to GeneCards/GeneDecks:

(show top 50)    (show all 141)
idCompoundScoreTop Affiliating Genes
1ranitidine44 28 11 2413.5CCK, MLN, SCT
2caerulein4410.5MLN, SCT, CCK
3pancreozymin4410.5GAST, SCT, CCK
4loxiglumide4410.5GAST, SCT, CCK
5lafutidine4410.5SCT, MLN, GAST
6glp-1 (7-36)amide4410.5SCT, GAST, GCG
7pepsinogen4410.4CCK, SCT, GAST
8peptone4410.4GCG, GAST, CCK
9rimonabant44 28 1112.4GHRL, GCG, CCK
10pramlintide44 1111.4GCG, CCK, GHRL
11pirenzepine44 28 1112.4GAST, GHRL, GCG, CCK
12bethanechol44 28 1112.4MLN, CCK, GAST, GCG
13cisapride44 28 1112.4MLN, GCG, CCK, MLNR
14epft4410.4CCK, SCT
15omeprazole44 28 49 11 2414.3CCK, SCT, GAST, MLN
16ipamorelin4410.3GHRL, GHSR
17norepinephrine44 11 2412.3CCK, ADRA1D, ADRA1B, GAST
18cyproheptadine28 44 1112.3CCK, ADRA1D, ADRA1B
19erythromycin44 49 2 1113.3GHRL, MLNR, GAST, MLN
20dtpa4410.3GAST, GCG, CCK
21c-peptide4410.3GAST, GCG, CCK, SCT, GHRL
22tetrodotoxin44 59 2812.3CCK, NOS1, MLN, SCT, GCG
23orlistat44 59 1112.3GHRL, CCK, GCG
24ondansetron44 49 11 2413.3MLN, GAST, CCK
25acetaminophen44 2 49 11 2414.3MLN, GAST, CCK, GCG, GHRL
26risperidone28 44 49 59 11 2415.2GHRL, SCT, ADRA1B, ADRA1D
27corticosterone44 59 2412.2GCG, GAST, NOS1, GHRL
28carbachol44 28 1112.2NOS1, CCK, GCG, GHRL, SCT, GAST
29acth4410.2CCK, GHSR, GAST, MLN, GHRL, SCT
30oxyntomodulin44 5911.2GAST, SCT, GHRL, GCG, CCK, MLN
31clozapine44 28 49 1113.2ADRA1D, NOS1, GHRL, ADRA1B
32gaba4410.2SCT, CCK, GAST, GHRL, NOS1, GCG
33ns-492810.1ADRA1D, ADRA1B
34octreotide44 59 28 1113.1MLN, GHSR, CCK, SCT, GAST, GHRL
35atropine44 28 1112.1GHRL, MLN, GAST, SCT, CCK, GCG
36histamine44 28 2412.0GHRL, MLN, SCT, CCK, GAST, GCG
37nicardipine28 44 1112.0ADRA1B, CCK, ADRA1D
385-hydroxytryptamine4410.0GHRL, NOS1, MLN, ADRA1B, CCK, GCG
39epinephrine44 11 2412.0ADRA1B, GHRL, GAST, SCT, GCG, ADRA1D
40acetylcholine44 49 28 11 2413.9MLN, GHRL, HMOX2, SCT, CCK, GCG
41nitric oxide44 11 2411.9KCNE1, MRC1, MLN, GHRL, GHSR, NOS1
42nifedipine44 49 28 1112.9MLN, GAST, GCG, GHRL
43arginine449.8GHSR, MLN, CCK, GCG, KCNE1, NOS1
44adenylate449.8NOS1, GHSR, KCNE1, GCG, CCK, GHRL
45glutamate449.8NOS1, GCG, SCT, ADRA1B, HMOX2, GAST
46glucose449.8GCG, CCK, SCT, MLN, GHSR, GAST
47cocaine44 1110.7GCG, GHRL, NOS1, CCK
48serine449.6GCG, NOS1, GHRL, GAST, ADRA1B, SCT
49dopamine44 28 11 2412.5ADRA1B, MLN, GCG, CCK, SCT, GAST
50calcium44 49 11 2412.3HMOX2, GHSR, MLN, MLNR, GAST, ADRA1D

GO Terms for genes affiliated with Gastroparesis

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16Gene Ontology
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Cellular components related to Gastroparesis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:03477410.2GHRL, GCG

Biological processes related to Gastroparesis according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of appetiteGO:03210010.6GHSR, GHRL
2negative regulation of tumor necrosis factor biosynthetic processGO:04253610.6GHRL, GHSR
3regulation of delayed rectifier potassium channel activityGO:190225910.5KCNE2, KCNE1
4membrane repolarizationGO:08600910.5KCNE2, KCNE1
5negative regulation of interleukin-6 biosynthetic processGO:04540910.5GHSR, GHRL
6membrane repolarization involved in regulation of action potentialGO:08601110.5KCNE2, KCNE1
7negative regulation of interleukin-1 beta productionGO:03269110.5GHRL, GHSR
8regulation of potassium ion transmembrane transportGO:190137910.5KCNE1, KCNE2
9growth hormone secretionGO:03025210.5GHSR, GHRL
10potassium ion exportGO:07143510.4KCNE2, KCNE1
11adult feeding behaviorGO:00834310.4GHSR, GHRL
12regulation of cardiac muscle cell action potential involved in contractionGO:08600210.4KCNE1, KCNE2
13actin polymerization or depolymerizationGO:00815410.3GHRL, GHSR
14hormone-mediated signaling pathwayGO:00975510.3GHRL, GHSR
15regulation of ventricular cardiac muscle cell membrane repolarizationGO:06030710.2KCNE1, KCNE2
16regulation of cardiac muscle contractionGO:05511710.1NOS1, ADRA1B
17decidualizationGO:04669710.0GHRL, GHSR
18G-protein coupled receptor signaling pathwayGO:0071869.7ADRA1D, GCG, GAST, MLNR, MLN, GHSR

Molecular functions related to Gastroparesis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarizationGO:190228210.2KCNE2, KCNE1
2alpha1-adrenergic receptor activityGO:00493710.0ADRA1B, ADRA1D
3growth hormone-releasing hormone receptor activityGO:0165209.9GHSR, MLNR
4hormone activityGO:0051799.8MLN, GAST, SCT, CCK, GCG

Products for genes affiliated with Gastroparesis

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Gastroparesis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet