Gastroschisis disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Gastroschisis

Sources:
⁶³Wikipedia, ⁴⁶OMIM, ³²MalaCards
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Wikipedia:⁶³ Gastroschisis represents a congenital defect characterized by a defect in the anterior abdominal wall... more...

MalaCards: Gastroschisis, also known as congenital fissure of the abdominal cavity, is related to omphalocele and hypertension, and has symptoms including gastroschisis, mesenterium anomaly/common mesentery/mesenteric adhesion and intestinal atresia/stenosis/absence/agenesis/hypoplasia (excludes duodenum). An important gene associated with Gastroschisis is ACHE (acetylcholinesterase), and among its related pathways are NO-dependent CFTR activation (normal and CF) and glutamine degradation I. The compounds estrogen and glutamate have been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and colon, and related mouse phenotypes are skeleton and muscle.

Description from OMIM:⁴⁶ 230750

Aliases & Classifications for Gastroschisis

Sources:
⁸Disease Ontology, ⁴²NIH Rare Diseases, ¹⁰DISEASES, ⁴⁴Novoseek, ⁴⁸Orphanet, ⁴⁶OMIM, ⁶⁰UMLS, ³⁴MeSH, ⁵⁶SNOMED-CT, ²⁷ICD9CM, ³⁹NCIt, ³⁵MESH via Orphanet, ²⁶ICD10 via Orphanet, ⁵⁷SNOMED-CT via Orphanet, ⁶¹UMLS via Orphanet, ²⁵ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases
Anatomical: Gastrointestinal diseases

ICD10: ²⁶ ²⁵

Congenital malformations, deformations and chromosomal abnormalities

Congenital malformations and deformations of the musculoskeletal system

Congenital malformations of the musculoskeletal system, not elsewhere classified

Gastroschisis

Characteristics (Orphanet epidemiological data):

⁴⁸

gastroschisis:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Neonatal/infancy; Age of death: Normal

Aliases & Descriptions:

gastroschisis ⁸ ⁴² ¹⁰ ⁴⁴ ⁴⁸ ⁴⁶ ⁶⁰

congenital fissure of the abdominal cavity ⁴²

laparoschisis ⁴⁸

External Ids:

Disease Ontology⁸ DOID:11044

MeSH³⁴ D020139

ICD9CM²⁷ 756.73

NCIt³⁹ C84725

OMIM⁴⁶ 230750

SNOMED-CT⁵⁶ 72951007

MESH via Orphanet³⁵ D020139

ICD10 via Orphanet²⁶ Q79.3

SNOMED-CT via Orphanet⁵⁷ 72951007

UMLS via Orphanet⁶¹ C0265706

ICD10²⁵ Q79.3

UMLS⁶⁰ C0265706

Related Diseases for Gastroschisis

Sources:
¹⁷GeneCards, ¹⁸GeneDecks
See all sources

Diseases related to Gastroschisis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 203)

id	Related Disease	Score	Top Affiliating Genes
1	omphalocele	30.0	AFP, ACHE
2	hypertension	30.0	ICAM1, CST3, NPPA, F5, MTHFR, F2
3	respiratory failure	29.8	ICAM1
4	cholestasis	29.8	F2, SLPI
5	hepatitis	29.8	AFP, F2
6	deficiency anemia	29.8	F2, NOS1
7	hepatitis a	29.8	F2
8	ischemia	29.8	ICAM1, CST3, MPO, NOS3, NOS1
9	intestinal atresia	10.5
10	congenital diaphragmatic hernia	10.2
11	short bowel syndrome	10.1
12	esophagitis	10.1
13	abdominal wall defect	10.1
14	gastric dilatation	10.0
15	cryptorchidism	10.0
16	neuronitis	10.0
17	hirschsprung's disease	10.0
18	craniosynostosis	10.0
19	oligohydramnios	10.0
20	glaucoma	10.0	ACHE
21	hyperthyroidism	10.0	SLPI
22	sarcoma	10.0	SLPI
23	hypothyroidism	10.0	CST3
24	meningioma	10.0	CST3
25	gingivitis	10.0	CST3
26	pulmonary emphysema	10.0	SLPI
27	polyneuropathy	10.0	ACHE
28	nephrotic syndrome	10.0	NPPA
29	pre-eclampsia	10.0	AFP
30	peripheral vascular disease	10.0	MPO
31	sickle cell disease	10.0	NOS3
32	hypercholesterolemia	10.0	NOS3
33	choriocarcinoma	10.0	AFP
34	portal hypertension	10.0	NOS3
35	lupus nephritis	10.0	ICAM1
36	hepatopulmonary syndrome	10.0	NOS3
37	hydrocephalus	10.0	AFP
38	proliferative diabetic retinopathy	10.0	ICAM1
39	varicose veins	10.0	F2
40	acute pancreatitis	10.0	SULT1A3, MPO
41	nephritis	10.0	SULT1A3, MPO
42	eclampsia	10.0	MTHFR
43	extragonadal germ cell tumor	10.0	AFP
44	wegener's granulomatosis	10.0	SLPI, MPO
45	migraine	10.0	MTHFR
46	cystic fibrosis	10.0	SLPI, MPO
47	malaria	10.0	ICAM1, ACHE
48	von willebrand's disease	10.0	F2
49	multiple sclerosis	10.0	CST3, ICAM1
50	myeloma	10.0	ICAM1, CST3

Graphical network of the top 20 diseases related to Gastroschisis:

Clinical Features for Gastroschisis

Sources:
⁴⁶OMIM, ⁴⁸Orphanet
See all sources

Clinical features from OMIM:

230750

Clinical synopsis from OMIM:

230750

Symptoms:

⁴⁸

gastroschisis
mesenterium anomaly/common mesentery/mesenteric adhesion

intestinal atresia/stenosis/absence/agenesis/hypoplasia (excludes duodenum)

Drugs & Therapeutics for Gastroschisis

Sources:
⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶⁰UMLS, ⁴⁰NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Gastroschisis

Drug clinical trials:

Search ClinicalTrials for Gastroschisis

Search NIH Clinical Center for Gastroschisis

Search CenterWatch for Gastroschisis

Genetic Tests for Gastroschisis

Anatomical Context for Gastroschisis

Sources:
³²MalaCards
See all sources

MalaCards organs/tissues related to Gastroschisis:

³²

Small intestine, Liver, Colon, Skin, Placenta, Smooth muscle, Testis, Heart, Kidney, Brain

Animal Models for Gastroschisis or affiliated genes

Sources:
³⁶MGI
See all sources

MGI Mouse Phenotypes related to Gastroschisis:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	skeleton phenotype	MP:0005390	9.5	NOS1, NOS3, HOXB5, BMP1
2	muscle phenotype	MP:0005369	8.7	ICAM1, CST3, NPPA, NOS3, NOS1, ACHE
3	cardiovascular system phenotype	MP:0005385	8.2	CST3, NPPA, BMP1, ARID3B, MPO, F2
4	hematopoietic system phenotype	MP:0005397	7.7	ICAM1, NPPA, MPO, F2, SLPI, NOS3
5	nervous system phenotype	MP:0003631	7.3	ICAM1, CST3, ARID3B, F5, MTHFR, HOXB5
6	homeostasis/metabolism phenotype	MP:0005376	6.4	ADD1, ICAM1, CST3, NPPA, F5, MPO
7	growth/size phenotype	MP:0005378	6.3	ICAM1, BMP1, BMP6, ARID3B, F5, AEBP1
8	mortality/aging	MP:0010768	6.1	AEBP1, MPO, F5, ARID3B, BMP1, ICAM1

Publications for Gastroschisis

Sources:
⁵⁰PubMed
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Articles related to Gastroschisis:

(show top 50) (show all 593)

id	Title	Authors	Year
1	Gastroschisis, destructive brain lesions, and placental infarction in the second trimester suggest a vascular pathogenesis. (23895144)	Folkerth R.D.... Elliott A.J.	2013
2	Enteric nervous system impairment in gastroschisis. (23100056)	Auber F.... Audry G.	2013
3	Intra-amniotic administration of urinary trypsin inhibitor preserves intestinal contractility in meconium induced intestinal damage in chick embryos with gastroschisis. (23895961)	KarakuA9 O.Z.... AkgA1r F.M.	2013
4	Gastroschisis treatment: what are the causes of high morbidity and mortality rates? (23958095)	TarcA8 E.... Aprodu S.G.	2013
5	Gastroschisis. (23763807)	Bano R.... Mushtaq A.	2013
6	Left-sided gastroschisis with placenta findings: case report and literature review. (22558479)	Shi Y.... Carpenter P.M.	2012
7	Anencephaly and gastroschisis in the same foetus: a rarity. (23520683)	Jha T.... Chowdhury S.	2012
8	The prevalence of preterm births in pregnancies complicated with fetal gastroschisis. (22660889)	Barseghyan K.... Miller D.A.	2012
9	Fetoscopic management of gastroschisis in a lamb model. (22179441)	Bergholz R.... Hecher K.	2012
10	Is complex gastroschisis predictable by prenatal ultrasound? (22017923)	Kuleva M.... Salomon L.J.	2012
11	Omphalocele, gastroschisis: epidemiology, survival, and mortality in Imam Khomeini hospital, Ahvaz-Iran. (22487740)	Askarpour S.... Chabi S.	2012
12	Primary suture-less closure of gastroschisis using negative pressure dressing (wound vacuum). (21780019)	Hassan S.F.... Pimpalwar A.	2011
13	Gastroschisis. (22089733)	Nichol P.F.	2011
14	Does gastric dilation predict adverse perinatal or surgical outcome in fetuses with gastroschisis? (21264982)	Alfaraj M.A.... Kingdom J.	2011
15	Closed gastroschisis. (21113601)	Shalaby A.... Davenport M.	2011
16	Effective surveillance of gastroschisis and omphalocele: separate International Classification of Diseases, Ninth Revision codes! (21292106)	Chabra S.	2011
17	Changes in amniotic fluid index after maternal oral hydration in pregnancies with fetal gastroschisis: initial observations. (20606383)	Brizot M.L.... Zugaib M.	2010
18	No free ride? The hidden costs of delayed operative management using a spring-loaded silo for gastroschisis. (20638519)	Lobo J.D.... Mychaliska G.B.	2010
19	Pathogenic implications of remnant vitelline structures in gastroschisis. (20920723)	Komuro H.... Kaneko M.	2010
20	Gastroschisis in mice lacking aortic carboxypeptidase-like protein is associated with a defect in neuromuscular development of the eviscerated intestine. (20386491)	Danzer E.... Flake A.W.	2010
21	Case-control study of a gastroschisis cluster in Nevada. (19884590)	Elliott L.... Todd R.	2009
22	Mode of delivery and neonatal survival of infants with gastroschisis in Australia and New Zealand. (18779007)	Abdel-Latif M.E.... Lui K.	2008
23	The outcome of gastroschisis after a prenatal diagnosis or a diagnosis only at birth. Recommendations for prenatal surveillance. (18068889)	Cohen-Overbeek T.E.... Tibboel D.	2008
24	Prenatal ultrasonographic gastrointestinal abnormalities in fetuses with gastroschisis do not correlate with postnatal outcomes. (18405710)	Badillo A.T.... Adzick N.S.	2008
25	Gastroschisis: clinical presentation and associations. (18655099)	Hunter A.G.... Stevenson R.E.	2008
26	Preservation of extracorporeal tissue in closing gastroschisis augments intestinal length. (19040937)	Estrada J.J.... Shaul D.B.	2008
27	Intestinal transplantation for short bowel syndrome secondary to gastroschisis. (17101355)	Wada M.... Tzakis A.	2006
28	Three-dimensional magnetic resonance imaging after ultrasonography for assessment of fetal gastroschisis. (16455410)	Sasaki Y.... Aburano T.	2006
29	Urinary trypsin inhibitor present in fetal urine prevents intraamniotic meconium-induced intestinal damage in gastroschisis. (16863846)	Olguner M.... AkgA1r F.M.	2006
30	Family cases of gastroschisis. (15852295)	Schmidt A.I.... Ure B.M.	2005
31	Increasing prevalence of gastroschisis in Utah. (15793731)	Hougland K.T.... Null D.	2005
32	Gastroschisis revisited: role of intraoperative measurement of abdominal pressure. (15937815)	Olesevich M.... Cotman K.	2005
33	Surveillance and outcome of fetuses with gastroschisis. (14970991)	Brantberg A.... Eik-Nes S.H.	2004
34	Fetal gastrointestinal motility in a rabbit model of gastroschisis. (15017553)	Oyachi N.... Atkinson J.B.	2004
35	Gastroschisis: the effect of labor and ruptured membranes on neonatal outcome. (14710097)	Strauss R.A.... McMahon M.J.	2003
36	Effects of prenatal dexamethasone on the intestine of rats with gastroschisis. (12861532)	Yu J.... Tovar J.A.	2003
37	Gastroschisis: A sixteen-year review. (12720191)	Baerg J.... Reid D.	2003
38	Benefits of term delivery in infants with antenatally diagnosed gastroschisis. (12576270)	Lenke R.	2003
39	Prenatal management of gastroschisis: the place of the amnioexchange procedure. (14533896)	Luton D.... de Lagausie P.	2003
40	Meconium dependence of bowel damage in gastroschisis. (12077782)	Tanyel F.C.	2002
41	Gastroschisis and omphalocele. (10798139)	Puri A.... Bajpai M.	1999
42	Intraoperative vascular assessment for estimation of risk in primary closure of omphalocele and gastroschisis. (24057523)	Pistor G.... Streich R.	1996
43	Omphalocele and gastroschisis in Europe: a survey of 3 million births 1980-1990. EUROCAT Working Group. (8533813)	Calzolari E.... Milan M.	1995
44	Does ascertainment bias contribute to the reported association of omphalocele and gastroschisis with other birth defects in families but not in individuals? (8135295)	Hook E.B.	1993
45	Gastroschisis and intestinal atresia. (1832714)	Shah R.... Woolley M.M.	1991
46	Fetal gastroschisis and omphalocele: is cesarean section the best mode of delivery? (2144949)	Lewis D.F.... Major C.A.	1990
47	Abdominal wall defects: omphalocele and gastroschisis (continuing education credit). (2961975)	Frentner S.	1987
48	Prenatal diagnosis of omphalocele and gastroschisis by ultrasonography. (2418434)	Nielsen L.B.... rgaard-Pedersen B.	1985
49	Primary fascial closure in infants with gastroschisis and omphalocele: a superior approach. (6229619)	Canty T.G.... Collins D.L.	1983
50	Immediate permanent fascial prosthesis for gastroschisis and massive omphalocele. (6454268)	Stone H.H.	1981

Genes related to Gastroschisis

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc.
See all sources

Genes related to Gastroschisis:

(show all 21)

id	Symbol	Description	Score	Implication
1	ACHE	acetylcholinesterase	20.47	GeneCards inferred : Publications, Disorders (show sections)
2	HOXB5	homeobox B5	19.50	GeneCards inferred : Disorders (show sections)
3	SULT1A3	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3	18.54	GeneCards inferred : Disorders (show sections)
4	BMP1	bone morphogenetic protein 1	17.59	GeneCards inferred : Publications, Disorders (show sections)
5	CST3	cystatin C	16.64	GeneCards inferred : Publications, Disorders (show sections)
6	ADD1	adducin 1 (alpha)	15.69	GeneCards inferred : Publications, Disorders (show sections)
7	MPO	myeloperoxidase	14.73	GeneCards inferred : Publications, Disorders (show sections)
8	NPPA	natriuretic peptide A	13.78	GeneCards inferred : Publications, Disorders (show sections)
9	AFP	alpha-fetoprotein	12.83	GeneCards inferred : Disorders (show sections)
10	ICAM1	intercellular adhesion molecule 1	11.88	GeneCards inferred : Publications, Disorders (show sections)
11	NOS3	nitric oxide synthase 3 (endothelial cell)	10.93	GeneCards inferred : Publications, Disorders (show sections)
12	F2	coagulation factor II (thrombin)	9.97	GeneCards inferred : Publications, Disorders (show sections)
13	NOS1	nitric oxide synthase 1 (neuronal)	9.02	GeneCards inferred : Publications, Disorders (show sections)
14	MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)	8.07	GeneCards inferred : Publications, Disorders (show sections)
15	F5	coagulation factor V (proaccelerin, labile factor)	7.12	GeneCards inferred : Publications, Disorders (show sections)
16	AEBP1	AE binding protein 1	6.16	GeneCards inferred : Publications, Disorders (show sections)
17	PRUNE	prune exopolyphosphatase	5.21	GeneCards inferred : Disorders (show sections)
18	ARID3B	AT rich interactive domain 3B (BRIGHT-like)	4.26	GeneCards inferred : Disorders (show sections)
19	SLPI	secretory leukocyte peptidase inhibitor	3.31	GeneCards inferred : Publications, Disorders (show sections)
20	BMP6	bone morphogenetic protein 6	2.35	GeneCards inferred : Publications, Disorders (show sections)
21	IL6	interleukin 6 (interferon, beta 2)	1.40	GeneCards inferred : Publications, Disorders (show sections)

Products for genes related to Gastroschisis disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	21	21	21
2	LSBio	-	-	21

Genetic Variations for Gastroschisis

Expression for genes affiliated with Gastroschisis

Sources:
¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Gastroschisis

Search GEO for disease gene expression data for Gastroschisis.

Pathways for genes affiliated with Gastroschisis

Sources:
³⁷NCBI BioSystems Database, ⁵¹QIAGEN
See all sources

Pathways related to Gastroschisis according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	NO-dependent CFTR activation (normal and CF)	9.9	NOS1, NOS3
2	glutamine degradation I³⁷ Hide members citrulline-nitric oxide cycle³⁷ superpathway of citrulline metabolism³⁷	9.9	NOS1, NOS3
3	Selenium Pathway³⁷	9.7	F2, MPO, ICAM1
4	G-Beta Gamma Signaling⁵¹ Hide members CRHR Pathway⁵¹ Relaxin Pathway⁵¹ Hedgehog Signaling in Mammals⁵¹	8.8	BMP1, BMP6, NOS3, NOS1

Compounds for genes affiliated with Gastroschisis

Sources:
⁴⁴Novoseek, ⁴⁹PharmGKB, ²⁸IUPHAR, ¹¹DrugBank, ²⁴HMDB, ⁵⁹Tocris Bioscience, ²BitterDB
See all sources

Compounds related to Gastroschisis according to GeneCards/GeneDecks:

(show top 50) (show all 160)

id	Compound	Score	Top Affiliating Genes
1	estrogen⁴⁴	10.7	SULT1A3
2	glutamate⁴⁴	10.5	ACHE, BMP1
3	tamoxifen⁴⁴ ⁴⁹ ²⁸ ¹¹	13.2	SLPI
4	metoprolol⁴⁴ ²⁸ ⁴⁹ ¹¹ ²⁴	14.0	NPPA, ICAM1, NOS3
5	bivalirudin⁴⁴ ¹¹	10.9	F2, MPO, F5
6	N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-(3-chlorobenzyl)ethane-1,2-diamine¹¹	9.9	NOS3, NOS1
7	serine⁴⁴	9.8	BMP1, ACHE, ADD1, MPO, AFP
8	cystathionine⁴⁴	9.8	F5, CST3, MTHFR
9	Nitroarginine¹¹	9.8	NOS1, NOS3
10	apocynin⁴⁴ ⁵⁹	10.8	ICAM1, MPO, NOS1, NOS3
11	allopurinol⁴⁴ ⁴⁹ ¹¹	11.8	MPO, NOS1, NOS3, ICAM1
12	matrigel⁴⁴	9.7	NOS3, SLPI
13	aprotinin⁴⁴ ¹¹	10.7	SLPI, F5
14	carboplatin⁴⁴ ⁴⁹ ¹¹	11.7	CST3, AFP, MTHFR, MPO
15	ng-nitro-l-arginine⁴⁴	9.7	NOS1, NOS3, NPPA
16	N-{(4s)-4-Amino-5-[(2-Aminoethyl)Amino]Pentyl}-N'-Nitroguanidine¹¹	9.6	NOS3, NOS1
17	kininogen⁴⁴	9.5	NPPA, F2, MPO, F5, CST3
18	vitamin b12⁴⁴	9.5	CST3, MPO, F5, AFP, MTHFR
19	uric acid⁴⁴ ²⁴	10.4	SLPI, AFP, F5, CST3
20	dopamine⁴⁴ ²⁸ ¹¹ ²⁴	12.4	SULT1A3, BMP6, NOS1
21	methacholine⁴⁴ ¹¹	10.4	SLPI, MPO, ICAM1, NOS1
22	cyclophosphamide⁴⁴ ⁴⁹ ¹¹	11.3	AFP, NOS3, MPO, F5, MTHFR
23	homocysteine⁴⁴ ²⁴	10.2	F2, MTHFR, SULT1A3, CST3, F5, NOS3
24	cyclosporin a⁴⁴ ²⁸ ⁵⁹	11.2	CST3, F2, ICAM1, NOS1, SLPI
25	azathioprine⁴⁴ ⁴⁹ ² ¹¹	12.1	MTHFR, SLPI, AFP, NOS3
26	nacl⁴⁴	9.1	SLPI, AFP, NPPA, F5, SULT1A3
27	folate⁴⁴	9.1	F5, MTHFR, NOS3, CST3, NOS1, AFP
28	aspartate⁴⁴	8.9	SULT1A3, CST3, F2, AFP, BMP6, BMP1
29	arginine⁴⁴	8.9	SULT1A3, NOS3, F5, BMP1, NPPA, CST3
30	prostacyclin⁴⁴	8.8	NPPA, BMP6, F5, NOS3, ICAM1
31	sodium dodecylsulfate⁴⁴	8.8	NPPA, BMP6, F5, NOS3
32	epinephrine⁴⁴ ¹¹ ²⁴	10.7	F2, NPPA, BMP6, F5, AFP, SULT1A3
33	carbachol⁴⁴ ²⁸ ¹¹	10.6	BMP6, ACHE, NOS3, NOS1, SLPI
34	simvastatin⁴⁴ ⁴⁹ ⁵⁹ ²⁸ ¹¹ ²⁴	13.6	ICAM1, BMP6, F5, AFP, F2, NOS3
35	cholesterol⁴⁴ ²⁸ ¹¹ ²⁴	11.6	F5, ADD1, SULT1A3, SLPI, AFP, MTHFR
36	dexamethasone⁴⁴ ⁴⁹ ²⁸ ¹¹	11.6	NOS1, BMP6, AFP, SULT1A3, SLPI
37	aspirin⁴⁴ ⁴⁹ ²⁸ ²⁴	11.5	SULT1A3, F2, BMP6, NOS3, F5, MTHFR
38	ascorbic acid⁴⁴ ²⁴	9.4	MTHFR, MPO, ICAM1, F5, SLPI, NOS3
39	heparin⁴⁴ ²⁸ ¹¹ ²⁴	11.4	SLPI, BMP1, BMP6, MPO, AFP, MTHFR
40	methotrexate⁴⁴ ⁴⁹ ¹¹	10.4	NOS1, BMP6, MTHFR, AFP, F2, NOS3
41	fibrinogen⁴⁴	8.3	F5, MTHFR, SULT1A3, F2, SLPI, ICAM1
42	polyethylene glycol⁴⁴	8.2	CST3, ICAM1, F2, AFP, MPO, F5
43	cisplatin⁴⁴ ⁴⁹ ⁵⁹ ¹¹	11.2	MTHFR, BMP6, CST3, MPO, AFP, SLPI
44	lactate⁴⁴	7.8	SLPI, ICAM1, CST3, BMP6, F5, F2
45	calcium⁴⁴ ⁴⁹ ¹¹ ²⁴	10.6	AFP, MPO, F5, BMP1, NPPA, CST3
46	creatinine⁴⁴	7.6	BMP6, F5, AFP, SLPI, NOS1, SULT1A3
47	alanine⁴⁴	7.4	NOS1, SLPI, AFP, F2, BMP6, MTHFR
48	retinoic acid⁴⁴ ²⁴	8.3	F5, AFP, BMP6, SLPI, ICAM1, MPO
49	nitric oxide⁴⁴ ¹¹ ²⁴	9.3	ADD1, SULT1A3, NOS1, NOS3, SLPI, MPO
50	vegf⁴⁴	7.3	AFP, SLPI, NOS1, NOS3, MPO, F5

GO Terms for genes affiliated with Gastroschisis

Sources:
¹⁶Gene Ontology
See all sources

Cellular components related to Gastroschisis according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:005576	8.3	NPPA, BMP1, F5, F2, SLPI, ACHE
2	extracellular space	GO:005615	6.7	ACHE, ICAM1, CST3, NPPA, BMP1, BMP6

Biological processes related to Gastroschisis according to GeneCards/GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	ovulation from ovarian follicle	GO:001542	10.1	NOS3, AFP
2	positive regulation of guanylate cyclase activity	GO:031284	10.0	NOS1, NOS3
3	negative regulation of hydrolase activity	GO:051346	10.0	NOS1, NOS3
4	arginine catabolic process	GO:006527	9.9	NOS1, NOS3
5	negative regulation of platelet activation	GO:010544	9.9	F2, NOS3
6	nitric oxide biosynthetic process	GO:006809	9.9	NOS1, NOS3
7	negative regulation of potassium ion transport	GO:043267	9.8	NOS1, NOS3
8	negative regulation of calcium ion transport	GO:051926	9.6	NOS3, ICAM1

Molecular functions related to Gastroschisis according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	nitric-oxide synthase activity	GO:004517	10.0	NOS1, NOS3
2	tetrahydrobiopterin binding	GO:034617	9.9	NOS1, NOS3
3	arginine binding	GO:034618	9.9	NOS1, NOS3
4	cadmium ion binding	GO:046870	9.9	NOS1, NOS3
5	NADPH-hemoprotein reductase activity	GO:003958	9.6	NOS1, NOS3
6	calmodulin binding	GO:005516	9.1	AEBP1, NOS3, NOS1, ADD1

Products for genes affiliated with Gastroschisis

Antibodies
Proteins
Lysates

Antibodies

Sources for Gastroschisis

¹BioGPS

²BitterDB

³CDC

⁴Cell Signaling Technology

⁵CenterWatch

⁶ClinicalTrials

⁷dbSNP

⁸Disease Ontology

⁹diseasecard

¹⁰DISEASES

¹¹DrugBank

¹²EMD Millipore

¹³ExPASy

¹⁴FMA

¹⁵Gene Expression Omnibus DataSets

¹⁶Gene Ontology

¹⁷GeneCards

¹⁸GeneDecks

¹⁹GeneReviews

²⁰GeneTests

²¹Genetics Home Reference

²²GTR

²³HGMD

²⁴HMDB

²⁵ICD10

²⁶ICD10 via Orphanet

²⁷ICD9CM

²⁸IUPHAR

²⁹KEGG

³⁰LifeMap Discovery™

³¹LifeSpan BioSciences, Inc.

³²MalaCards

³³MedlinePlus

³⁴MeSH

³⁵MESH via Orphanet

³⁶MGI

³⁷NCBI BioSystems Database

³⁸NCBI Bookshelf

³⁹NCIt

⁴⁰NDF-RT

⁴¹NIH Clinical Center

⁴²NIH Rare Diseases

⁴³NINDS

⁴⁴Novoseek

⁴⁵Novus Biologicals

⁴⁶OMIM

⁴⁷OMIM via Orphanet

⁴⁸Orphanet

⁴⁹PharmGKB

⁵⁰PubMed

⁵¹QIAGEN

⁵²R&D Systems

⁵³Reactome

⁵⁴SABiosciences

⁵⁵SinoBiological

⁵⁶SNOMED-CT

⁵⁷SNOMED-CT via Orphanet

⁵⁸Thomson Reuters

⁵⁹Tocris Bioscience

⁶⁰UMLS

⁶¹UMLS via Orphanet

⁶²UniProtKB/Swiss-Prot

⁶³Wikipedia

MCID: GST009 MIFTS: 63	Gastroschisis malady Gastrointestinal diseases, Fetal diseases categories
3 symptoms, 21 genes, 10 tissues, 203 related diseases, clinical trials.

Gastroschisis malady