Gastroschisis disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Gastroschisis

Sources:
⁴⁶OMIM, ⁶⁴Wikipedia, ³²MalaCards
See all sources

OMIM:⁴⁶ Gastroschisis is a congenital defect of the abdominal wall that occurs laterally to, and often to the right of, a... (230750) more...

MalaCards based summary: Gastroschisis, also known as congenital fissure of the abdominal cavity, is related to omphalocele and anencephaly, and has symptoms including gastroschisis, abnormality of the mesentery and gastroschisis. An important gene associated with Gastroschisis is ACHE (acetylcholinesterase (Yt blood group)), and among its related pathways are LDL Oxidation in Atherogenesis and NO dependent CFTR activation normal and CF . The compounds bivalirudin and allopurinol have been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and colon, and related mouse phenotypes are adipose tissue and vision/eye.

Wikipedia:⁶⁴ Gastroschisis represents a congenital defect characterized by a defect in the anterior abdominal wall... more...

Aliases & Classifications for Gastroschisis

Sources:
⁹Disease Ontology, ⁴²NIH Rare Diseases, ¹¹DISEASES, ⁴⁴Novoseek, ⁴⁸Orphanet, ⁴⁶OMIM, ⁶¹UMLS, ³⁴MeSH, ³⁹NCIt, ²⁸ICD9CM, ⁵⁶SNOMED-CT, ³⁵MESH via Orphanet, ²⁷ICD10 via Orphanet, ⁶²UMLS via Orphanet, ²⁶ICD10
See all sources

Gastroschisis, Aliases & Descriptions:

Name: Gastroschisis ⁹ ⁴² ¹¹ ⁴⁴ ⁴⁸ ⁴⁶ ⁶¹

Congenital Fissure of the Abdominal Cavity ⁴² ⁶¹

Laparoschisis ⁴⁸

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Fetal diseases
Anatomical: Gastrointestinal diseases

ICD10: ²⁷ ²⁶

Congenital malformations, deformations and chromosomal abnormalities

Congenital malformations and deformations of the musculoskeletal system

Congenital malformations of the musculoskeletal system, not elsewhere classified

Gastroschisis

Orphanet: ⁴⁸

Rare gastroenterological diseases

Developmental anomalies during embryogenesis

Characteristics (Orphanet epidemiological data):

⁴⁸

gastroschisis:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Neonatal/infancy; Age of death: Normal

External Ids:

Disease Ontology⁹ DOID:11044

MeSH³⁴ D020139

NCIt³⁹ C84725

ICD9CM²⁸ 756.73

OMIM⁴⁶ 230750

SNOMED-CT⁵⁶ 72951007

MESH via Orphanet³⁵ D020139

ICD10 via Orphanet²⁷ Q79.3

UMLS via Orphanet⁶² C0265706

ICD10²⁶ Q79.3

UMLS⁶¹ C0265706

Related Diseases for Gastroschisis

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
See all sources

Diseases related to Gastroschisis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 172)

id	Related Disease	Score	Top Affiliating Genes
1	omphalocele	32.1	AFP, ACHE
2	anencephaly	30.2	AFP, ACHE, MTHFR
3	neural tube defects	30.2	ACHE, AFP, MTHFR
4	ischemia	29.9	ICAM1, MPO, CST3, NOS1, NOS3
5	thromboembolism	29.7	MTHFR, F2, NOS3, F5
6	hypertension	29.1	NPPA, NOS3, F5, MTHFR, ICAM1, CST3
7	abdominal wall defect	10.5
8	pre-eclampsia	10.5	AFP
9	intestinal atresia	10.5
10	mitral valve disease	10.5	NPPA
11	branch retinal artery occlusion	10.5	F5
12	sick sinus syndrome	10.5	NPPA
13	factor xii deficiency	10.5	F5
14	poems syndrome	10.4	IL6
15	polyarteritis nodosa	10.4	MPO
16	achalasia	10.4	ACHE, NOS1
17	congenital nephrotic syndrome finnish type	10.4	ACHE, AFP
18	hemophilia b	10.4	F2
19	pure autonomic failure	10.4	ACHE, NPPA
20	hepatorenal syndrome	10.4	F2, NPPA
21	adult respiratory distress syndrome	10.4	SLPI, CST3
22	rapidly progressive glomerulonephritis	10.4	ICAM1, MPO
23	vitamin k deficiency hemorrhagic disease	10.4	F2, AFP
24	stroke, ischemic	10.3	F5, F2
25	immunoglobulin a vasculitis	10.3	MPO, ICAM1
26	acute chest syndrome	10.3	NOS3
27	prothrombin deficiency	10.3	F2, F5
28	factor x deficiency	10.3	F5, F2
29	leukostasis	10.3	MPO, ICAM1
30	vascular disease	10.3	IL6, NOS1
31	factor v deficiency	10.3	F2, F5
32	huntington's disease	10.3	ACHE, ADD1, NOS1
33	factor xi deficiency	10.3	F5, F2
34	dysfibrinogenemia	10.3	F2, F5
35	central retinal vein occlusion	10.3	F5, MTHFR
36	hemorrhagic disease	10.3	F2, F5
37	homocysteinemia	10.3	MTHFR, F5
38	scott syndrome	10.3	F2, F5
39	von willebrand's disease	10.3	F5, F2
40	placental abruption	10.3	F5, MTHFR
41	allergic rhinitis	10.3	MPO, ICAM1
42	hepatic vein thrombosis	10.3	MTHFR, F5
43	factor vii deficiency	10.3	F5, F2
44	vascular dementia	10.3	ACHE, MTHFR, CST3
45	factor viii deficiency	10.3	F5, F2
46	retinal vein occlusion	10.3	MTHFR, F5
47	viral hepatitis	10.3	AFP, F2, SLPI
48	afibrinogenemia	10.3	F5, F2
49	cerebrovascular disease	10.3	MTHFR, ACHE, CST3
50	intracranial thrombosis	10.3	MTHFR, F5

Graphical network of the top 20 diseases related to Gastroschisis:

Symptoms for Gastroschisis

Sources:
⁴⁶OMIM, ⁵⁸The Human Phenotype Ontology, ⁴⁸Orphanet
See all sources

Symptoms by clinical synopsis from OMIM:

230750

Clinical features from OMIM:

230750

Symptoms:

⁴⁸

gastroschisis
intestinal atresia/stenosis/absence/agenesis/hypoplasia (excludes duodenum)

mesenterium anomaly/common mesentery/mesenteric adhesion

HPO human phenotypes related to Gastroschisis:

id	Description	Frequency	HPO Source Accession
1	gastroschisis	hallmark (90%)	HP:0001543
2	abnormality of the mesentery	occasional (7.5%)	HP:0100016
3	gastroschisis		HP:0001543

Drugs & Therapeutics for Gastroschisis

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶¹UMLS, ⁴⁰NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Gastroschisis

Search NIH Clinical Center for Gastroschisis

Genetic Tests for Gastroschisis

Anatomical Context for Gastroschisis

Sources:
³²MalaCards
See all sources

MalaCards organs/tissues related to Gastroschisis:

³²

Small intestine, Liver, Colon, Skin, Brain, Heart, Smooth muscle, Kidney, Placenta, Testis

Animal Models for Gastroschisis or affiliated genes

Sources:
³⁶MGI
See all sources

MGI Mouse Phenotypes related to Gastroschisis:

³⁶ (show all 14)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	adipose tissue phenotype	MP:0005375	8.4	AEBP1, ACHE, IL6, NOS1, NOS3
2	vision/eye phenotype	MP:0005391	8.1	ICAM1, MTHFR, ACHE, IL6, NOS1, NOS3
3	reproductive system phenotype	MP:0005389	8.1	F2, AFP, MTHFR, ACHE, BMP6, NOS1
4	muscle phenotype	MP:0005369	8.1	MPO, ICAM1, ACHE, IL6, CST3, NOS1
5	integument phenotype	MP:0010771	7.9	F5, IL6, MTHFR, ICAM1, AEBP1, F2
6	digestive/alimentary phenotype	MP:0005381	7.8	F2, AEBP1, ICAM1, IL6, BMP1, NOS1
7	skeleton phenotype	MP:0005390	7.7	F2, HOXB5, MTHFR, IL6, BMP1, BMP6
8	endocrine/exocrine gland phenotype	MP:0005379	7.6	AEBP1, AFP, ICAM1, IL6, NOS1, NOS3
9	cardiovascular system phenotype	MP:0005385	7.4	F2, MPO, ICAM1, IL6, BMP1, CST3
10	nervous system phenotype	MP:0003631	7.1	ICAM1, ADD1, HOXB5, F2, MTHFR, ACHE
11	hematopoietic system phenotype	MP:0005397	6.9	ICAM1, ADD1, MPO, F2, ACHE, IL6
12	growth/size/body phenotype	MP:0005378	6.2	F2, AEBP1, ADD1, ICAM1, MTHFR, ACHE
13	mortality/aging	MP:0010768	5.4	ICAM1, ADD1, MPO, AFP, AEBP1, F2
14	homeostasis/metabolism phenotype	MP:0005376	5.1	SLPI, F2, AEBP1, AFP, MPO, ADD1

Publications for Gastroschisis

Sources:
⁵¹PubMed
See all sources

Articles related to Gastroschisis:

(show top 50) (show all 610)

id	Title	Authors	Year
1	Anomalies associated with gastroschisis and omphalocele: analysis of 2825 cases from the Texas Birth Defects Registry. (24726103)	Benjamin B.... Wilson G.N.	2014
2	Prevalence and risk factors for gastroschisis in a public hospital from west MAcxico. (25243388)	Robledo-Aceves M.... Corona-Rivera J.R.	2014
3	Gastroschisis, omphalocele or something else? (23531629)	Chan L.C.... Ng P.C.	2014
4	Left-sided Gastroschisis: A Rare Congenital Anomaly. (24298510)	Mandelia A.... Panda S.	2013
5	Gastric contractility in experimental gastroschisis. (23414860)	Cavalcante M.B.... Melo-Filho A.A.	2013
6	Human milk versus formula after gastroschisis repair: effects on time to full feeds and time to discharge. (23519369)	Kohler J.A.... Bass W.T.	2013
7	Gastroschisis, destructive brain lesions, and placental infarction in the second trimester suggest a vascular pathogenesis. (23895144)	Folkerth R.D.... Elliott A.J.	2013
8	Corticosteroid effect upon intestinal and hepatic interleukin profile in a gastroschisis rat model. (23381817)	GonAsalves F.L.... Sbragia L.	2013
9	Left-sided gastroschisis with placenta findings: case report and literature review. (22558479)	Shi Y.... Carpenter P.M.	2012
10	Evolution of critically ill patients with gastroschisis from three tertiary centers. (21437430)	Tannuri A.C.... Camperoni A.L.	2011
11	Assessing the trend of gastroschisis prevalence in China from 1996 to 2007 using two analytical methods. (21308975)	Xu L.... Zhu J.	2011
12	Ultrasound prediction of birthweight and growth restriction in fetal gastroschisis. (20723876)	Chaudhury P.... Goodnight W.H.	2010
13	Changes in amniotic fluid index after maternal oral hydration in pregnancies with fetal gastroschisis: initial observations. (20606383)	Brizot M.L.... Zugaib M.	2010
14	Evisceration and necrosis of gall bladder and evisceration of urinary bladder in a patient of gastroschisis. (20098013)	Mirza B.... Sheikh A.	2010
15	Benchmarking the quality of care of infants with low-risk gastroschisis using a novel risk stratification index. (20236674)	Chang D.C.... Abdullah F.	2010
16	Perinatal demography of gastroschisis in North Queensland. (21166913)	Whitehall J.S.... Gill A.	2010
17	Gastroschisis and intrauterine growth restriction. (20362958)	Jelsema R.	2010
18	Mirror image left-sided gastroschisis. (20618216)	Patel R.... Ninan G.K.	2010
19	Gastroschisis associated with an intra-abdominal umbilical vein varix: a report of 2 cases. (19786788)	Fung T.Y.... Lau T.K.	2009
20	Escape of the yolk sac: a hypothesis to explain the embryogenesis of gastroschisis. (19419415)	Stevenson R.E.... Hunter A.G.	2009
21	Spontaneous sutureless closure of the abdominal wall defect in gastroschisis using a commercial wound retractor system. (19705131)	Ogasawara Y.... Yamataka A.	2009
22	Re: M. B. Forrester and R. D. Merz (2006), Comparison of trends in gastroschisis and prenatal illicit drug use rates. J. Toxicol. Environ. Health A 69:1253-1259. (18080905)	Chabra S.	2008
23	Rare case of fetal gastroschisis with aplasia of the foot and external genital organs. (18778459)	Rao S.R.... Rao A.V.	2008
24	Anaesthetic management of gastroschisis - a review of our practice over the past 5 years. (18613932)	Raghavan M.... Montgomerie J.	2008
25	Novel intra-operative pulse oximetry monitoring for gastroschisis: a noninvasive monitor of intra-abdominal pressure. (18315652)	Hong C.M.... Patel A.	2008
26	Fetal abdominal wall repair with a collagen biomatrix in an experimental sheep model for gastroschisis. (18636946)	Roelofs L.A.... Wijnen R.M.	2008
27	Scheduled preterm delivery for gastroschisis improves postoperative outcome. (18668252)	Gelas T.... DuBois R.	2008
28	Non-genetic risk factors for gastroschisis. (18655102)	Rasmussen S.A.... FrA-as J.L.	2008
29	Outcomes in neonatal gastroschisis: an institutional experience. (17992713)	Vachharajani A.J.... Mathur A.M.	2007
30	Ruptured omphalocele with extracorporeal intestines mimicking gastroschisis in a fetus with Turner syndrome. (17694577)	Chen C.P.	2007
31	Outcomes of pregnancies with fetal gastroschisis. (17766615)	Santiago-Munoz P.C.... Dashe J.S.	2007
32	Splanchnic perfusion pressure: a better predictor of safe primary closure than intraabdominal pressure in neonatal gastroschisis. (16677879)	McGuigan R.M.... Azarow K.S.	2006
33	Does gastroschisis reduction require general anesthesia? A comparative analysis. (16818066)	Cauchi J.... Gornall P.	2006
34	Erythropoietin restores bowel damage and hypoperistalsis in gastroschisis. (16481250)	Ozdamar A.... Hosgor M.	2006
35	Primary fascial closure in 112 infants with gastroschisis. (16146253)	Thepcharoennirund S.	2005
36	A "plastic" sutureless abdominal wall closure in gastroschisis. (15137009)	Sandler A.... Soper R.	2004
37	Fetal home monitoring for the prenatal management of gastroschisis. (15488122)	Salomon L.J.... Dommergues M.	2004
38	Isolated gastroschisis in successive siblings: a case report and review of the literature. (15193205)	Snelling C.M.... Davies G.A.	2004
39	The effect on the intestines of continuous release of methylene blue from a drug delivery system: an experimental study in a chick embryo gastroschisis model. (15338173)	Denli O.... Cedden F.	2004
40	Gastroschisis: the effect of labor and ruptured membranes on neonatal outcome. (14710097)	Strauss R.A.... McMahon M.J.	2003
41	Elective delayed midgut reduction-No anesthesia for gastroschisis: Selection and conversion criteria. (12194127)	Bianchi A.... Alizai N.K.	2002
42	Unusual presentations of gastroschisis. (12206609)	Ashburn D.A.... Turner C.S.	2002
43	The outcome and analysis of 40 cases of fetal gastroschisis. (12370717)	Malas N.O.... Shwyiat R.M.	2002
44	An unusual case of gastroschisis with gallbladder evisceration and late postrepair chylous ascites. (9434035)	Drinnen D.... Filston H.C.	1997
45	Omphalocele and gastroschisis in Europe: a survey of 3 million births 1980-1990. EUROCAT Working Group. (8533813)	Calzolari E.... Milan M.	1995
46	Genetic-epidemiologic study of omphalocele and gastroschisis: evidence for heterogeneity. (1481831)	Yang P.... Gordis L.	1992
47	Abdominal wall defects: omphalocele and gastroschisis (continuing education credit). (2961975)	Frentner S.	1987
48	Omphalocele, hernia of the umbilical cord and gastroschisis. (6232916)	Verco P.W.	1983
49	Congenital abdominal wall defects: gastroschisis and omphalocele. (6211335)	Grosfeld J.L.... Weber T.R.	1982
50	Perinatal aspects of omphalocele and gastroschisis. (930890)	Colombani P.M.... Cunningham M.D.	1977

Genes related to Gastroschisis

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals
See all sources

Genes related to Gastroschisis:

(show all 18)

- Elite gene

id	Symbol	Description	Score	Implication
1	ACHE	acetylcholinesterase (Yt blood group)	20.55	GeneCards inferred via : Publications, Disorders (show sections)
2	HOXB5	homeobox B5	19.42	GeneCards inferred via : Disorders (show sections)
3	BMP1	bone morphogenetic protein 1	18.31	GeneCards inferred via : Publications (show sections)
4	ADD1	adducin 1 (alpha)	17.19	GeneCards inferred via : Publications (show sections)
5	CST3	cystatin C	16.08	GeneCards inferred via : Publications (show sections)
6	MPO	myeloperoxidase	14.97	GeneCards inferred via : Publications (show sections)
7	NOS1	nitric oxide synthase 1 (neuronal)	13.86	GeneCards inferred via : Publications (show sections)
8	NPPA	natriuretic peptide A	12.75	GeneCards inferred via : Publications (show sections)
9	AFP	alpha-fetoprotein	11.64	GeneCards inferred via : Disorders (show sections)
10	F2	coagulation factor II (thrombin)	10.53	GeneCards inferred via : Publications (show sections)
11	F5	coagulation factor V (proaccelerin, labile factor)	9.42	GeneCards inferred via : Publications (show sections)
12	ICAM1	intercellular adhesion molecule 1	8.30	GeneCards inferred via : Publications (show sections)
13	MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)	7.19	GeneCards inferred via : Publications (show sections)
14	NOS3	nitric oxide synthase 3 (endothelial cell)	6.08	GeneCards inferred via : Publications (show sections)
15	IL6	interleukin 6 (interferon, beta 2)	4.97	GeneCards inferred via : Publications (show sections)
16	AEBP1	AE binding protein 1	3.86	GeneCards inferred via : Publications, Disorders (show sections)
17	SLPI	secretory leukocyte peptidase inhibitor	2.75	GeneCards inferred via : Publications (show sections)
18	BMP6	bone morphogenetic protein 6	1.64	GeneCards inferred via : Publications (show sections)

Products for genes related to Gastroschisis disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	18	-	18	18
2	Novus Biologicals	18	16	18	-

Variations for Gastroschisis

Expression for genes affiliated with Gastroschisis

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Gastroschisis

Search GEO for disease gene expression data for Gastroschisis.

Pathways for genes affiliated with Gastroschisis

Sources:
⁴⁹PathCards, ⁵²QIAGEN, ⁵⁹Thomson Reuters, ³⁷NCBI BioSystems Database, ⁵⁰PharmGKB, ⁵⁴Reactome, ³⁰KEGG
See all sources

Pathways related to Gastroschisis according to GeneCards/GeneDecks:

(show all 18)

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	LDL Oxidation in Atherogenesis⁵²	9.8	ICAM1, MPO
2	NO dependent CFTR activation normal and CF ⁵⁹	9.8	NOS3, NOS1
3	Effects of nitric oxide³⁷ Show member pathways Quercetin and Nf-kB/ AP-1 induced cell apoptosis³⁷	9.8	NOS3, NOS1
4	Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics⁵⁰	9.8	NOS3, NOS1
5	Nitric oxide stimulates guanylate cyclase⁵⁴ Show member pathways cGMP effects⁵⁴	9.8	NOS3, NOS1
6	Collagen biosynthesis and modifying enzymes⁵⁴ Show member pathways Anchoring fibril formation⁵⁴ Blood Coagulation Cascade⁵² Collagen formation⁵⁴ Crosslinking of collagen fibrils⁵⁴ Intrinsic Prothrombin Activation Pathway⁵² Assembly of collagen fibrils and other multimeric structures⁵⁴	9.6	F2, BMP1, F5
7	amb2 Integrin signaling³⁷	9.3	MPO, ICAM1, IL6
8	Spinal Cord Injury³⁷	9.3	NOS1, IL6, ICAM1
9	Glucocorticoid receptor regulatory network³⁷	9.3	AFP, ICAM1, IL6
10	HIF-1 signaling pathway³⁰	9.2	IL6, NOS3, NPPA
11	Hemostasis⁵⁴ Show member pathways Platelet activation, signaling and aggregation⁵⁴	9.1	F2, F5, NOS1, NOS3
12	G-Beta Gamma Signaling⁵² Show member pathways CRHR Pathway⁵² Relaxin Pathway⁵² GHRH Signaling⁵² Hedgehog Signaling in Mammals⁵²	9.0	NOS3, NOS1, BMP6, BMP1
13	Immune response IL 23 signaling pathway⁵⁹ Show member pathways IL23-mediated signaling events³⁷ Angiopoietin-TIE2 Signaling⁵² Immune response IL 10 signaling pathway⁵⁹ Angiopoietin receptor Tie2-mediated signaling³⁷ Development PDGF signaling via STATs and NF kB⁵⁹ Development Angiopoietin Tie2 signaling⁵⁹	8.9	NOS3, IL6, MPO, F2
14	p70S6K Signaling⁵² Show member pathways Renin-Angiotensin Pathway⁵² mTOR Pathway⁵²	8.9	F2, IL6, BMP1, BMP6
15	Nanog in Mammalian ESC Pluripotency⁵² Show member pathways GSK3 Signaling⁵² eNOS Signaling⁵² 14-3-3 Induced Intracellular Signaling⁵²	8.8	NOS3, BMP6, BMP1, IL6
16	Selenium Pathway³⁷ Show member pathways thioredoxin pathway³⁷	8.6	IL6, MTHFR, ICAM1, MPO, F2
17	Activation of cAMP-Dependent PKA⁵² Show member pathways PKA Signaling⁵² Activation of PKA through GPCR⁵² cAMP Pathway⁵²	8.5	ADD1, IL6, BMP1, BMP6, NOS3
18	PEDF Induced Signaling⁵² Show member pathways all-trans-Retinoic Acid Signaling in Brain⁵² Cytokine-cytokine receptor interaction³⁰ NFAT Signaling and Lymphocyte Interactions⁵² STAT3 Pathway⁵² RAR-Gamma-RXR-Alpha Degradation⁵² PGC1Alpha Pathway⁵² Glucocorticoid Receptor Signaling⁵² IL-6 Pathway⁵² Endothelin-1 Signaling Pathway⁵² MIF Regulation of Innate Immune Cells⁵² MIF Mediated Glucocorticoid Regulation⁵²	8.2	F2, IL6, BMP1, BMP6, NOS1, NOS3

Compounds for genes affiliated with Gastroschisis

Sources:
⁴⁴Novoseek, ¹²DrugBank, ⁵⁰PharmGKB, ⁶⁰Tocris Bioscience, ²⁵HMDB, ²⁹IUPHAR
See all sources

Compounds related to Gastroschisis according to GeneCards/GeneDecks:

(show top 50) (show all 221)

id	Compound	Score	Top Affiliating Genes
1	bivalirudin⁴⁴ ¹²	10.6	F5, F2, MPO
2	allopurinol⁴⁴ ⁵⁰ ¹²	11.5	MPO, NOS3, NOS1, ICAM1
3	apocynin⁴⁴ ⁶⁰	10.5	NOS3, MPO, NOS1, ICAM1
4	kininogen⁴⁴	9.4	F2, CST3, F5, NPPA, MPO
5	vitamin b12⁴⁴	9.3	AFP, MTHFR, MPO, F5, CST3
6	8-isoprostane⁴⁴	9.2	NOS3, IL6, MPO, ICAM1
7	dextran sulfate⁴⁴	9.1	IL6, ICAM1, MPO, F5
8	taurine chloramine⁴⁴	9.1	IL6, F5, MPO
9	homocysteine⁴⁴ ²⁵	10.1	F2, CST3, F5, MTHFR, NOS3
10	cyclophosphamide⁴⁴ ⁵⁰ ¹²	11.0	NOS3, MTHFR, F5, AFP, MPO
11	methacholine⁴⁴ ⁵⁰ ¹²	11.0	NOS1, SLPI, MPO, ICAM1
12	pentoxifylline⁴⁴ ¹²	9.9	MPO, BMP6, IL6, ICAM1
13	folate⁴⁴	8.9	AFP, CST3, F5, NOS1, NOS3, MTHFR
14	pravastatin⁴⁴ ⁵⁰ ²⁹ ²⁵ ¹²	12.8	MTHFR, NOS3, ICAM1, NOS1, IL6
15	uric acid⁴⁴ ²⁵	9.7	F5, CST3, AFP, MTHFR, SLPI
16	prostacyclin⁴⁴	8.7	ICAM1, BMP6, NPPA, NOS3, F5
17	aprotinin⁴⁴ ¹²	9.6	CST3, IL6, F5, SLPI, F2
18	atorvastatin⁴⁴ ⁵⁰ ²⁹ ²⁵ ¹²	12.6	ICAM1, BMP6, IL6, F5, NOS3
19	epinephrine⁴⁴ ²⁵ ¹²	10.6	F5, NPPA, IL6, AFP, F2, BMP6
20	carbachol⁴⁴ ²⁹ ¹²	10.5	BMP6, NOS3, NOS1, ACHE, SLPI
21	aspirin⁴⁴ ⁵⁰ ²⁹ ²⁵	11.3	NOS3, F5, F2, BMP6, MTHFR
22	fluvastatin⁴⁴ ⁵⁰ ²⁹ ¹²	11.3	SLPI, NOS3, ICAM1, IL6
23	polyethylene glycol⁴⁴	8.3	CST3, AFP, MPO, ICAM1, BMP6, F5
24	hyaluronic acid⁴⁴ ²⁵	9.2	ICAM1, IL6, SLPI, F2, BMP6
25	endotoxin⁴⁴	8.1	BMP6, F5, IL6, ICAM1, SLPI
26	glutamate⁴⁴	8.1	F5, NOS3, BMP1, ACHE, AFP, MTHFR
27	tamoxifen⁴⁴ ⁵⁰ ²⁹ ¹²	11.1	SLPI, NOS3, F2, BMP6, F5, NOS1
28	simvastatin⁴⁴ ⁵⁰ ⁶⁰ ²⁹ ²⁵ ¹²	13.1	IL6, F2, ICAM1, AFP, NOS3, F5
29	histamine⁴⁴ ²⁹ ²⁵	10.0	BMP6, MPO, NOS1, SLPI, ICAM1, IL6
30	ascorbic acid⁴⁴ ²⁵	9.0	F5, NOS1, ICAM1, NOS3, SLPI, MPO
31	cisplatin⁴⁴ ⁵⁰ ⁶⁰ ¹²	10.9	CST3, MTHFR, MPO, SLPI, AFP, BMP6
32	cholesterol⁴⁴ ²⁹ ²⁵ ¹²	10.9	ADD1, MTHFR, IL6, CST3, F5, SLPI
33	methotrexate⁵⁰ ⁴⁴ ¹²	9.9	IL6, BMP6, CST3, NOS1, NOS3, AFP
34	testosterone⁴⁴ ⁶⁰ ²⁵ ¹²	10.8	MTHFR, AFP, SLPI, F5, NPPA, NOS1
35	pge2⁴⁴	7.8	IL6, SLPI, MPO, NPPA, NOS1, BMP6
36	vitamin d⁴⁴	7.8	AFP, MTHFR, IL6, BMP6, SLPI, NOS3
37	heparin⁴⁴ ²⁹ ²⁵ ¹²	10.7	BMP1, BMP6, MTHFR, F2, SLPI, F5
38	dexamethasone⁴⁴ ⁵⁰ ²⁹ ¹²	10.6	AFP, ICAM1, IL6, BMP6, CST3, NOS1
39	fibrinogen⁴⁴	7.6	MTHFR, AFP, F2, ICAM1, IL6, CST3
40	aspartate⁴⁴	7.5	MTHFR, F2, AFP, BMP1, BMP6, CST3
41	calcium⁴⁴ ⁵⁰ ²⁵ ¹²	10.3	NOS3, NOS1, NPPA, SLPI, AFP, F5
42	lactate⁴⁴	7.2	F5, SLPI, CST3, BMP6, IL6, MPO
43	cyclosporin a⁴⁴ ²⁹ ⁶⁰	9.2	NPPA, F2, ICAM1, MTHFR, NOS1, IL6
44	alanine⁴⁴	6.9	F2, AFP, BMP1, BMP6, CST3, F5
45	nitric oxide⁴⁴ ²⁵ ¹²	8.8	IL6, BMP6, MPO, ADD1, NOS1, F5
46	estrogen⁴⁴	6.6	BMP6, IL6, MTHFR, AFP, SLPI, NPPA
47	creatinine⁴⁴	6.6	SLPI, F2, AFP, IL6, NPPA, NOS1
48	retinoic acid⁴⁴ ²⁵	7.6	IL6, MTHFR, SLPI, ICAM1, MPO, F5
49	vegf⁴⁴	6.5	SLPI, AFP, NOS1, NOS3, NPPA, F5
50	serine⁴⁴	6.3	CST3, SLPI, NOS1, F5, NOS3, BMP6

GO Terms for genes affiliated with Gastroschisis

Sources:
¹⁷Gene Ontology
See all sources

Cellular components related to Gastroschisis according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	membrane-bounded vesicle	GO:031988	9.7	BMP6, BMP1
2	extracellular region	GO:005576	8.0	F2, ACHE, IL6, BMP1, CST3, F5
3	extracellular space	GO:005615	6.2	NPPA, F2, AEBP1, AFP, MPO, ICAM1

Biological processes related to Gastroschisis according to GeneCards/GeneDecks:

(show all 18)

id	Name	GO ID	Score	Top Affiliating Genes
1	neurotransmitter biosynthetic process	GO:042136	10.2	NOS1, ACHE
2	negative regulation of hydrolase activity	GO:051346	10.1	NOS3, NOS1
3	positive regulation of guanylate cyclase activity	GO:031284	10.1	NOS1, NOS3
4	arginine catabolic process	GO:006527	10.0	NOS1, NOS3
5	negative regulation of potassium ion transport	GO:043267	10.0	NOS3, NOS1
6	ovulation from ovarian follicle	GO:001542	10.0	AFP, NOS3
7	negative regulation of platelet activation	GO:010544	10.0	F2, NOS3
8	nitric oxide biosynthetic process	GO:006809	10.0	NOS3, NOS1
9	regulation of blood vessel size	GO:050880	9.9	NOS3, NPPA
10	negative regulation of calcium ion transport	GO:051926	9.9	NOS3, ICAM1
11	nitric oxide mediated signal transduction	GO:007263	9.8	NOS3, NOS1
12	SMAD protein signal transduction	GO:060395	9.7	AFP, BMP6
13	response to heat	GO:009408	9.6	NOS3, NOS1, IL6
14	response to hypoxia	GO:001666	9.5	NPPA, NOS1, MTHFR
15	regulation of cell shape	GO:008360	9.5	F2, ICAM1, IL6
16	skeletal system development	GO:001501	9.2	BMP6, BMP1, AEBP1
17	cell adhesion	GO:007155	8.8	AEBP1, ICAM1, ACHE, F5
18	blood coagulation	GO:007596	8.8	NOS3, NOS1, F5, F2

Molecular functions related to Gastroschisis according to GeneCards/GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	nitric-oxide synthase activity	GO:004517	10.0	NOS3, NOS1
2	arginine binding	GO:034618	9.9	NOS1, NOS3
3	tetrahydrobiopterin binding	GO:034617	9.9	NOS1, NOS3
4	cadmium ion binding	GO:046870	9.8	NOS3, NOS1
5	NADPH-hemoprotein reductase activity	GO:003958	9.8	NOS1, NOS3
6	FMN binding	GO:010181	9.7	NOS3, NOS1
7	NADP binding	GO:050661	9.6	NOS3, NOS1, MTHFR
8	flavin adenine dinucleotide binding	GO:050660	9.5	NOS3, NOS1, MTHFR
9	cytokine activity	GO:005125	9.2	BMP6, BMP1, IL6
10	heme binding	GO:020037	9.2	NOS3, NOS1, MPO
11	growth factor activity	GO:008083	9.1	BMP6, BMP1, IL6, F2
12	calmodulin binding	GO:005516	9.1	AEBP1, ADD1, NOS1, NOS3

Products for genes affiliated with Gastroschisis

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Sources for Gastroschisis

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⁵⁷SNOMED-CT via Orphanet

⁵⁸The Human Phenotype Ontology

⁵⁹Thomson Reuters

⁶⁰Tocris Bioscience

⁶¹UMLS

⁶²UMLS via Orphanet

⁶³UniProtKB/Swiss-Prot

⁶⁴Wikipedia

MCID: GST009 MIFTS: 66	Gastroschisis malady Rare diseases, Gastrointestinal diseases, Fetal diseases categories
6 symptoms, 18 genes, 10 tissues, 172 related diseases, clinical trials Download this MalaCard Expand all tables

Gastroschisis malady

Summaries for Gastroschisis

Aliases & Classifications for Gastroschisis

Gastroschisis, Aliases & Descriptions:

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Characteristics (Orphanet epidemiological data):

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Related Diseases for Gastroschisis

Diseases related to Gastroschisis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

Graphical network of the top 20 diseases related to Gastroschisis:

Symptoms for Gastroschisis

Symptoms by clinical synopsis from OMIM:

Clinical features from OMIM:

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Compounds related to Gastroschisis according to GeneCards/GeneDecks:

GO Terms for genes affiliated with Gastroschisis

Cellular components related to Gastroschisis according to GeneCards/GeneDecks:

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