Gaze Palsy malady

Wikipedia: Conjugate gaze palsies are neurological disorders affecting the ability to move both eyes in the same...⁴⁴ more...

MalaCards: Gaze Palsy, also known as gaze palsies, is related to horizontal gaze palsy with progressive scoliosis and scoliosis. An important gene associated with Gaze Palsy is ROBO3 (roundabout, axon guidance receptor, homolog 3 (Drosophila)), and among its related pathways are Axon guidance and Cytoskeleton remodeling Slit-Robo signaling. The compounds thioflavin and formate have been mentioned in the context of this disorder. Related mouse phenotypes are no phenotypic analysis and mortality/aging.

gaze palsy 7 gaze palsies 43

Diseases related to gaze palsy by text searches and GeneDecks gene sharing:

(show top 50)    (show all 64)

id	Related Disease	Score	Top Affiliating Genes
1	horizontal gaze palsy with progressive scoliosis	35.5	ROBO3, ROBO1, ROBO4, ROBO2
2	scoliosis	33.9	ROBO4, ROBO3, ROBO1, ROBO2
3	seizures	27.6	HOXA1, MAPT, GBA, NHLRC1
4	ataxia	26.3	ROBO2, NHLRC1, TARDBP, SNCA, MAPT
5	duane retraction syndrome	13.2	ROBO3, HOXA1
6	gilles de la tourette syndrome	13.1	ROBO4, ROBO3
7	progressive myoclonus epilepsy	12.9	NHLRC1, GBA
8	inclusion body myopathy	12.8	SNCA, TARDBP
9	vesicoureteral reflux	12.8	ROBO1, ROBO2, ROBO3, ROBO4
10	dysautonomia	12.7	GBA, SNCA
11	hermaphroditism	12.7	ROBO3, ROBO4, ROBO2, ROBO1
12	myoclonus epilepsy	12.7	GBA, NHLRC1
13	frontotemporal dementia, ubiquitin-positive	12.6	MAPT, SNCA
14	logopenic progressive aphasia	12.6	SNCA, MAPT
15	semantic dementia	12.6	TARDBP, MAPT
16	primary progressive aphasia	12.6	MAPT, TARDBP
17	essential tremor	12.6	SNCA, GBA, ATP13A2
18	lateral sclerosis	12.6	MAPT, SNCA
19	early-onset familial alzheimer disease	12.6	MAPT, SNCA
20	myoclonus	12.6	GBA, NHLRC1, SNCA
21	parkinson disease type 3	12.6	SNCA, MAPT
22	niemann-pick disease type c1	12.5	MAPT, SNCA
23	tremor	12.5	GBA, SNCA, ATP13A2
24	neuronal intranuclear inclusion disease	12.5	MAPT, SNCA
25	progressive supranuclear palsy	12.5	SNCA, MAPT
26	spinocerebellar ataxia type 3	12.5	TARDBP, SNCA
27	lewy body dementia	12.5	MAPT, SNCA
28	cognitive disease	12.5	MAPT, SNCA
29	tauopathy	12.5	SNCA, MAPT
30	vascular dementia	12.5	MAPT, SNCA
31	creutzfeldt-jakob syndrome	12.5	SNCA, MAPT
32	olivopontocerebellar atrophy	12.4	MAPT, SNCA
33	movement disease	12.3	MAPT, SNCA
34	memory impairment	12.2	SNCA, MAPT
35	niemann–pick disease	12.1	MAPT, GBA, SNCA
36	supranuclear palsy	12.1	MAPT, SNCA, GBA
37	corticobasal degeneration	12.1	MAPT, SNCA, TARDBP
38	prion disease	12.0	TARDBP, SNCA, MAPT
39	teratocarcinoma	12.0	MAPT, HOXA1, SNCA
40	frontotemporal dementia	12.0	MAPT, SNCA, TARDBP
41	motor neuron disease	12.0	TARDBP, SNCA, MAPT
42	amyloidosis	11.9	MAPT, GBA, SNCA
43	myositis	11.9	MAPT, TARDBP, SNCA
44	multiple system atrophy	11.8	MAPT, GBA, SNCA, ATP13A2
45	scrapie	11.7	LARS, MAPT
46	aphasia	11.7	SNCA, TARDBP, MAPT, HOXA1
47	parkinson's disease	11.7	GBA, MAPT, SNCA
48	neurodegenerative disease	11.6	MAPT, NHLRC1, SNCA, TARDBP
49	pick's disease	11.6	SNCA, MAPT, TARDBP, GBA
50	down syndrome	11.5	MAPT, SNCA, TARDBP, ROBO1

Approved drugs:

Drug clinical trials:

MGI Mouse Phenotypes related to gaze palsy:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	no phenotypic analysis	MP:0003012	7.4	TARDBP, ROBO4, SNCA, HOXA1, MAPT, NHLRC1
2	mortality/aging	MP:0010768	6.6	MAPT, HOXA1, SNCA, TARDBP, ROBO1, ROBO2
3	behavior/neurological phenotype	MP:0005386	6.6	MAPT, HOXA1, SNCA, TARDBP, GBA, NHLRC1
4	nervous system phenotype	MP:0003631	6.4	ROBO2, GBA, ROBO1, NHLRC1, SNCA, HOXA1
5	cellular phenotype	MP:0005384	6.0	NHLRC1, MAPT, SNCA, TARDBP, ROBO1, ROBO2

Articles related to gaze palsy:

(show all 15)

id	Title	Authors	Year	Affiliating Genes
1	Horizontal gaze palsy and progressive scoliosis witho ut ROBO3 mutations. (21510772)	Abu-Amero K.K.... Bosley T.M.	2011	ROBO3
2	Horizontal gaze palsy and progressive scoliosis due t o a deleterious mutation in ROBO3. (21592015)	Abu-Amero K.K.... Bosley T.M.	2011	ROBO3
3	Horizontal gaze palsy with progressive scoliosis: thr ee novel ROBO3 mutations and descriptions of the phenotypes of four patients. (21850172)	Volk A.E.... Neugebauer A.	2011	ROBO3
4	Diffusion tensor imaging in horizontal gaze palsy wit h progressive scoliosis. (20071118)	Avadhani A.... Rajasekaran S.	2010	ROBO3
5	TARDBP variation associated with frontotemporal demen tia, supranuclear gaze palsy, and chorea. (19609911)	Kovacs G.G.... Spina S.	2009	TARDBP
6	Five new consanguineous families with horizontal gaze palsy and progressive scoliosis and novel ROBO3 mutations. (18829051)	Abu-Amero K.K.... Bosley T.M.	2009	ROBO3
7	Allelic ROBO3 heterogeneity in Tunisian patients with horizontal gaze palsy with progressive scoliosis. (19633821)	Amouri R.... Hentati F.	2009	ROBO3
8	Functional MRI, DTI and neurophysiology in horizontal gaze palsy with progressive scoliosis. (18214457)	Haller S.... Lutschg J.	2008	ROBO3
9	Horizontal gaze palsy with progressive scoliosis can result from compound heterozygous mutations in ROBO3. (16525029)	Chan W.M.... Engle E.C.	2006	ROBO3
10	Patients with horizontal gaze palsy and progressive scoliosis due to ROBO3 E319K mutation have both uncrossed and crossed central nervous system pathways and perform normally on neuropsychological testing. (16772357)	Amoiridis G.... Plaitakis A.	2006	ROBO3
11	An autosomal recessive cerebellar ataxia syndrome with upward gaze palsy, neuropathy, and seizures. (15642921)	Straussberg R.... Berkovic S.F.	2005	NHLRC1
12	Neurologic features of horizontal gaze palsy and progressive scoliosis with mutations in ROBO3. (15824346)	Bosley T.M.... Baloh R.W.	2005	ROBO3
13	Familial horizontal gaze palsy with progressive scoliosis maps to chromosome 11q23-25. (12177379)	Jen J.... Baloh R.W.	2002	ROBO3
14	Progressive supranuclear gaze palsy is in linkage disequilibrium with the tau and not the alpha-synuclein gene. (9443491)	Higgins J.J.... Nee L.E.	1998	MAPT, SNCA
15	Isolated horizontal supranuclear gaze palsy as a marker of severe systemic involvement in Gaucher's disease. (8413956)	Patterson M.C.... Pikus A.	1993	GBA

Genes related to gaze palsy according to GeneCards:

(show all 11)

id	Symbol	Description	Score	GeneCards Section Context
1	ROBO3	roundabout, axon guidance receptor, homolog 3 (Drosophila)	11.1	Publications, Aliases & Descriptions, Orthologs, Summaries
2	ROBO4	roundabout, axon guidance receptor, homolog 4 (Drosophila)	11.0	Orthologs
3	ROBO1	roundabout, axon guidance receptor, homolog 1 (Drosophila)	11.0	Orthologs
4	ROBO2	roundabout, axon guidance receptor, homolog 2 (Drosophila)	11.0	Orthologs
5	NHLRC1	NHL repeat containing 1	11.0	Publications
6	ATP13A2	ATPase type 13A2	11.0
7	HOXA1	homeobox A1	11.0
8	TARDBP	TAR DNA binding protein	11.0	Publications
9	GBA	glucosidase, beta, acid	11.0	Publications
10	MAPT	microtubule-associated protein tau	11.0	Publications
11	SNCA	synuclein, alpha (non A4 component of amyloid precursor)	11.0	Publications

Pathways related to gaze palsy according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Axon guidance20	9.5	ROBO3, ROBO2, ROBO1
2	Cytoskeleton remodeling Slit-Robo signaling10	8.4	ROBO1, ROBO4, ROBO3, MAPT, ROBO2
3	Development_Slit-Robo signaling41	8.3	ROBO3, ROBO2, ROBO1, MAPT, ROBO4
4	Neuroscience3	7.9	TARDBP, SNCA, MAPT, ATP13A2

Compounds related to gaze palsy according to GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	thioflavin32	9.1	MAPT, SNCA
2	formate32	9.1	MAPT, SNCA
3	thioflavine s32	9.0	MAPT, SNCA
4	tmao32	8.8	MAPT, SNCA

Cellular components related to gaze palsy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	axon	GO:030424	8.8	MAPT, SNCA, ROBO3

Biological processes related to gaze palsy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of axonogenesis	GO:050772	9.8	ROBO1, ROBO2
2	negative regulation of negative chemotaxis	GO:050925	9.5	ROBO1, ROBO2
3	axon midline choice point recognition	GO:016199	9.4	ROBO1, ROBO2, ROBO3

Molecular functions related to gaze palsy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	axon guidance receptor activity	GO:008046	9.8	ROBO1, ROBO2