MCID: GMS001
MIFTS: 37

Gemistocytic Astrocytoma malady

Neuronal diseases, Cancer diseases, Rare diseases categories

Aliases & Classifications for Gemistocytic Astrocytoma

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 47Orphanet, 60UMLS, 55SNOMED-CT, 33MeSH, 38NCIt, 61UMLS via Orphanet
See all sources

Gemistocytic Astrocytoma, Aliases & Descriptions:

Name: Gemistocytic Astrocytoma 9 11 43 47 60
 
Gemistocytic Astrocytic Tumor 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology9 DOID:7005
MeSH33 D001254
NCIt38 C4321
SNOMED-CT55 73982001
Orphanet47 251604
UMLS via Orphanet61 C0334581

Summaries for Gemistocytic Astrocytoma

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MalaCards based summary: Gemistocytic Astrocytoma, also known as gemistocytic astrocytic tumor, is related to subependymal giant cell astrocytoma and astrocytoma. An important gene associated with Gemistocytic Astrocytoma is IDH2 (isocitrate dehydrogenase 2 (NADP+), mitochondrial), and among its related pathways are Nuclear signaling by ERBB4 and Gastric cancer network 2. The compounds eosin and s 100 have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and thyroid, and related mouse phenotypes are pigmentation and digestive/alimentary.

Related Diseases for Gemistocytic Astrocytoma

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Diseases related to Gemistocytic Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 58)
idRelated DiseaseScoreTop Affiliating Genes
1subependymal giant cell astrocytoma31.1GFAP
2astrocytoma30.5GFAP, PTEN, TP53, S100B, EGFR
3giant cell glioblastoma30.4GFAP, PTEN, EGFR
4glioblastoma29.3IDH2, GFAP, PTEN, TP53, S100B, EGFR
5pineoblastoma10.5GFAP
6mismatch repair cancer syndrome10.5PTEN
7fibrillary astrocytoma10.4
8myxopapillary ependymoma10.3S100B, GFAP
9papillary ependymoma10.3S100B, GFAP
10choroid plexus carcinoma10.3GFAP, S100B
11gliosarcoma10.3PTEN, GFAP
12choroid plexus papilloma10.3S100B, GFAP
13syringoma10.3GFAP, S100B
14pineocytoma10.3GFAP, S100B
15gliomatosis cerebri10.3PTEN, GFAP
16myoepithelioma10.3GFAP, S100B
17hemangioblastoma10.3GFAP, S100B
18ganglioglioma10.3GFAP, S100B
19chordoma10.3GFAP, S100B
20pleomorphic adenoma10.3S100B, GFAP
21fibrosarcoma10.2
22thyroiditis10.2
23vasculitis10.2
24neurilemmoma10.2S100B, GFAP
25malignant peripheral nerve sheath tumor10.2EGFR, S100B
26anaplastic ependymoma10.2S100B, PTEN, GFAP
27meningioma, familial10.2S100B, PTEN, GFAP
28ganglioneuroma10.2GFAP, PTEN, S100B
29pilocytic astrocytoma10.2S100B, PTEN, GFAP
30tuberous sclerosis10.1S100B, PTEN, GFAP
31malignant mixed mullerian tumor10.1TP53, S100B
32paraganglioma10.1S100B, GFAP, IDH2
33li-fraumeni syndrome10.1PTEN, TP53
34ependymoma10.1EGFR, S100B, GFAP
35oligodendroglioma10.0EGFR, PTEN, GFAP
36endometrial cancer10.0PTEN, TP53
37anaplastic oligodendroglioma10.0GFAP, PTEN, EGFR
38thyroid cancer, anaplastic10.0TP53, PTEN
39leiomyosarcoma10.0TP53, S100B
40ductal carcinoma in situ10.0EGFR, TP53
41papilloma10.0TP53
42breast ductal carcinoma10.0TP53, EGFR
43medulloblastoma10.0S100B, TP53, GFAP
44laryngeal carcinoma9.9EGFR, TP53
45bladder cancer, somatic9.9EGFR, TP53
46esophageal cancer9.9TP53, EGFR
47laryngeal squamous cell carcinoma9.8PTEN, TP53, EGFR
48renal cell carcinoma9.8EGFR, TP53
49stomach cancer9.8PTEN, TP53, EGFR
50colorectal cancer9.8PTEN, TP53, EGFR

Graphical network of the top 20 diseases related to Gemistocytic Astrocytoma:



Diseases related to gemistocytic astrocytoma

Symptoms for Gemistocytic Astrocytoma

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Drugs & Therapeutics for Gemistocytic Astrocytoma

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Drug clinical trials:

Search ClinicalTrials for Gemistocytic Astrocytoma

Search NIH Clinical Center for Gemistocytic Astrocytoma

Genetic Tests for Gemistocytic Astrocytoma

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Anatomical Context for Gemistocytic Astrocytoma

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MalaCards organs/tissues related to Gemistocytic Astrocytoma:

31
Brain, Spinal cord, Thyroid

Animal Models for Gemistocytic Astrocytoma or affiliated genes

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MGI Mouse Phenotypes related to Gemistocytic Astrocytoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.6PTEN, TP53, EGFR
2MP:00053818.2EGFR, TP53, PTEN, GFAP
3MP:00053918.1GFAP, PTEN, TP53, EGFR
4MP:00053798.1EGFR, SYCP3, TP53, PTEN
5MP:00028737.9EGFR, S100B, TP53, PTEN, GFAP
6MP:00053697.9GFAP, PTEN, TP53, EGFR

Publications for Gemistocytic Astrocytoma

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Articles related to Gemistocytic Astrocytoma:

(show all 14)
idTitleAuthorsYear
1
Perfusion MR imaging and MR spectroscopy of gemistocytic astrocytoma. (22115534)
2012
2
Unusual synchronous presentation of maxillary sinus fibrosarcoma and gemistocytic astrocytoma with a complication called leukocytoclastic vasculitis: a case report. (19756200)
2009
3
Immunohistochemical features of a feline spinal cord gemistocytic astrocytoma. (18987242)
2008
4
Cytologic characteristics of subependymal giant cell astrocytoma in squash smears: morphometric comparisons with gemistocytic astrocytoma and giant cell glioblastoma. (17536538)
2007
5
Congenital gemistocytic astrocytoma in a fetus. (15864706)
2006
6
Gemistocytic astrocytomas: histomorphology, proliferative potential and genetic alterations--a study of 32 cases. (16614946)
2006
7
November 2003: neonatal female with congenital brain tumor. Congenital gemistocytic astrocytoma. (15193038)
2004
8
Genotype-phenotype correlation in gemistocytic astrocytomas. (11152345)
2001
9
p53 and PTEN gene mutations in gemistocytic astrocytomas. (9650746)
1998
10
Multiple primary malignant tumours: gemistocytic astrocytoma with leptomeningeal spreading and papillary thyroid carcinoma. A case report. (2251958)
1990
11
Gemistocytic astrocytoma in a one-month-old llama. (2365629)
1990
12
A gemistocytic astrocytoma demonstrated high intensity on MR images. Protein hydration layer. (2398944)
1990
13
Development of Hodgkin's disease in a patient receiving procarbazine, CCNU, and vincristine therapy for a gemistocytic astrocytoma. (626997)
1978
14
Gemistocytic astrocytoma: cytological observations on the rate of hydrolysis of some phosphoric acid esters. (13301910)
1955

Variations for Gemistocytic Astrocytoma

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Expression for genes affiliated with Gemistocytic Astrocytoma

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Search GEO for disease gene expression data for Gemistocytic Astrocytoma.

Pathways for genes affiliated with Gemistocytic Astrocytoma

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Pathways related to Gemistocytic Astrocytoma according to GeneCards Suite gene sharing:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7GFAP, S100B
29.0EGFR, TP53
39.0EGFR, TP53
4
Show member pathways
9.0EGFR, TP53
58.6EGFR, TP53, GFAP
6
Show member pathways
8.6EGFR, S100B, PTEN, GFAP
78.6PTEN, TP53, EGFR
88.6PTEN, TP53, EGFR
98.6PTEN, TP53, EGFR
10
Show member pathways
8.6PTEN, TP53, EGFR
118.6PTEN, TP53, EGFR
128.6EGFR, TP53, PTEN
13
Show member pathways
8.6EGFR, TP53, PTEN
14
Show member pathways
Development EGFR signaling via PIP358
Development PDGF signaling via MAPK cascades58
Apoptosis and survival Anti apoptotic action of membrane bound ESR158
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases58
Development Neurotrophin family signaling58
Apoptosis and survival NGF signaling pathway58
Apoptosis and survival Role of CDK5 in neuronal death and survival58
8.6EGFR, TP53, PTEN
15
Show member pathways
Signal transduction PTEN pathway58
8.6EGFR, TP53, PTEN
168.6EGFR, TP53, PTEN
178.6EGFR, TP53, PTEN
18
Show member pathways
Signaling Pathways in Glioblastoma36
8.6EGFR, TP53, PTEN
198.6EGFR, TP53, PTEN
20
Show member pathways
8.2EGFR, TP53, PTEN, GFAP
21
Show member pathways
7.8GFAP, PTEN, TP53, S100B, EGFR

Compounds for genes affiliated with Gemistocytic Astrocytoma

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Compounds related to Gemistocytic Astrocytoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1eosin4310.1S100B, GFAP
2s 1004310.1S100B, GFAP
32,3-cyclic nucleotide4310.1S100B, GFAP
4reticulin4310.1S100B, GFAP
53-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide439.8PTEN, S100B
6panitumumab43 49 1211.8EGFR, PTEN
7cetuximab43 49 1211.7EGFR, PTEN
8bicalutamide43 59 1211.7PTEN, EGFR
9hematoxylin439.7GFAP, PTEN, S100B
10methionine439.6S100B, PTEN, GFAP
11erlotinib43 49 1211.6EGFR, PTEN
12ethanol43 49 24 1212.6S100B, PTEN, GFAP
13noxa439.5PTEN, TP53
14crcs439.5PTEN, TP53
15glycogen43 2410.5S100B, PTEN, GFAP
16dutp439.5GFAP, TP53
17indole-3-carbinol439.4TP53, PTEN
18imatinib43 49 1211.4EGFR, S100B, PTEN
19temozolomide43 1210.4EGFR, TP53
20trastuzumab43 49 1211.4EGFR, PTEN
21sn 3843 5910.4EGFR, TP53
22agar439.4EGFR, PTEN, GFAP
23pd 98,059439.3EGFR, PTEN, GFAP
24etoposide43 49 59 1212.2PTEN, TP53, S100B
25topotecan43 1210.2EGFR, TP53
26suberoylanilide hydroxamic acid439.1EGFR, TP53
27bcnu439.1GFAP, TP53, EGFR
28genistein43 28 59 2 24 1214.1GFAP, PTEN, EGFR
29oxaliplatin43 49 1211.0EGFR, TP53
30taxane439.0EGFR, TP53, PTEN
31testosterone43 59 24 1212.0GFAP, PTEN, S100B, EGFR
32bortezomib43 49 1211.0EGFR, TP53, PTEN
33gemcitabine43 49 1211.0PTEN, TP53, EGFR
34mg 13243 5910.0EGFR, TP53, PTEN
355fluorouracil439.0PTEN, TP53, EGFR
36flavopiridol43 129.9EGFR, TP53
37tamoxifen43 49 28 1211.9PTEN, TP53, EGFR
38ly294002438.9EGFR, TP53, PTEN
39doxorubicin43 49 1210.8PTEN, TP53, EGFR
40arginine438.8S100B, TP53, PTEN, GFAP
41cisplatin43 49 59 1211.6EGFR, TP53, PTEN, GFAP
42cycloheximide438.6GFAP, PTEN, TP53, EGFR
43thymidine43 249.6GFAP, TP53, S100B
44paclitaxel43 49 1210.2EGFR, S100B, TP53, PTEN, GFAP
45paraffin438.2GFAP, PTEN, TP53, S100B, EGFR
46progesterone43 28 59 24 1212.2GFAP, PTEN, TP53, S100B, EGFR
47vegf438.2EGFR, S100B, TP53, PTEN, GFAP
48estrogen438.2EGFR, S100B, TP53, PTEN, GFAP
49retinoic acid43 249.2GFAP, PTEN, TP53, S100B, EGFR
50serine438.2GFAP, PTEN, TP53, S100B, EGFR

GO Terms for genes affiliated with Gemistocytic Astrocytoma

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Cellular components related to Gemistocytic Astrocytoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00057377.3EGFR, S100B, TSGA10, TP53, PTEN, GFAP

Biological processes related to Gemistocytic Astrocytoma according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1memoryGO:00076139.5S100B, PTEN
2long-term synaptic potentiationGO:00602919.4S100B, PTEN, GFAP
3learning or memoryGO:00076119.2EGFR, S100B, PTEN
4cellular response to drugGO:00356909.0EGFR, TP53
5central nervous system developmentGO:00074178.9S100B, TP53, PTEN
6positive regulation of apoptotic processGO:00430658.9PTEN, TP53, S100B
7positive regulation of cell proliferationGO:00082848.7PTEN, S100B, EGFR
8negative regulation of apoptotic processGO:00430668.6EGFR, TP53, PTEN
9cell proliferationGO:00082838.4PTEN, TP53, S100B, EGFR

Molecular functions related to Gemistocytic Astrocytoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein phosphatase bindingGO:00199038.7EGFR, TP53
2identical protein bindingGO:00428028.7EGFR, S100B, TP53
3enzyme bindingGO:00198998.6EGFR, TP53, PTEN
4protein kinase bindingGO:00199018.5PTEN, TP53, EGFR

Products for genes affiliated with Gemistocytic Astrocytoma

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Sources for Gemistocytic Astrocytoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet