Gemistocytic Astrocytoma malady

MalaCards: Gemistocytic Astrocytoma, also known as gemistocytic astrocytoma (morphologic abnormality), is related to pilocytic astrocytoma and subependymal giant cell astrocytoma. An important gene associated with Gemistocytic Astrocytoma is S100B (S100 calcium binding protein B), and among its related pathways are Pathogenesis of ALS and Development_EGFR signaling via PIP3. The drugs cisplatin and cisplatin pwdr [va product] and the compounds adpribose and retinoic acid have been mentioned in the context of this disorder. Related mouse phenotypes are pigmentation and adipose tissue.

Aliases & Descriptions:

gemistocytic astrocytoma 6 8 32 43 gemistocytic astrocytoma (morphologic abnormality) 6

gemistocytic astrocytic tumor 6 astrocytoma 43

Diseases related to gemistocytic astrocytoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 334)

id	Related Disease	Score	Top Affiliating Genes
1	pilocytic astrocytoma	32.8	S100B, TP53, PTEN, EGFR, GFAP
2	subependymal giant cell astrocytoma	32.7	S100B, TP53, GFAP
3	anaplastic astrocytoma	32.1	S100B, TP53, PTEN, EGFR, GFAP
4	oligodendroglioma	31.1	PTEN, EGFR, GFAP
5	tuberous sclerosis	31.0	S100B, TP53, PTEN, GFAP
6	glioblastoma	30.9	BCL2, S100B, TP53, PTEN, EGFR, GFAP
7	astrocytoma	29.4	BCL2, S100B, TP53, PTEN, EGFR, GFAP
8	oligoastrocytoma	28.9	TP53, GFAP
9	diffuse astrocytoma	28.8	TP53, PTEN, EGFR, GFAP
10	anaplastic oligodendroglioma	28.3	TP53, PTEN, EGFR, GFAP
11	neuroblastoma	28.1	BCL2, S100B, TP53, PTEN, EGFR, GFAP
12	meningioma	27.7	BCL2, S100B, TP53, PTEN, EGFR, GFAP
13	cerebritis	27.4	BCL2, S100B, TP53, PTEN, EGFR, GFAP
14	ependymoma	27.3	S100B, TP53, PTEN, EGFR, GFAP
15	neurofibromatosis	27.3	S100B, TP53, PTEN, EGFR, GFAP
16	gliofibroma	27.2	S100B, GFAP
17	pleomorphic xanthoastrocytoma	27.0	TP53, EGFR, GFAP
18	central neurocytoma	26.8	BCL2, S100B, TP53, GFAP
19	medulloblastoma	26.8	BCL2, S100B, TP53, PTEN, EGFR, GFAP
20	pineoblastoma	26.7	TP53, GFAP
21	pituitary tumor	26.5	TP53, PTEN, EGFR
22	pleomorphic adenoma	26.4	S100B, GFAP
23	retinoblastoma	26.4	BCL2, S100B, TP53, PTEN, EGFR, GFAP
24	ganglioglioma	26.4	S100B, TP53, GFAP
25	neuroectodermal tumors	26.3	BCL2, S100B, TP53, PTEN, GFAP
26	chordoma	25.8	S100B, TP53, PTEN, GFAP
27	malignant glioma	25.8	BCL2, S100B, TP53, PTEN, EGFR, GFAP
28	neurofibroma	25.8	S100B, PTEN, EGFR
29	li-fraumeni syndrome	25.8	BCL2, TP53, PTEN
30	breast cancer	25.7	BCL2, TP53, PTEN
31	angiomyolipoma	25.6	S100B, TP53, EGFR
32	choroiditis	25.3	BCL2, S100B, TP53, GFAP
33	gliosis	25.2	S100B, TP53, EGFR, GFAP
34	adenoma	25.0	BCL2, S100B, TP53, PTEN, EGFR, GFAP
35	hemangioma	25.0	MRI1, TP53, PTEN, EGFR
36	thyroiditis	24.8	BCL2, S100B, TP53, PTEN, EGFR, GFAP
37	blastoma	24.8	BCL2, TP53, EGFR, GFAP
38	hypoxia	24.2	BCL2, S100B, TP53, PTEN, EGFR, GFAP
39	noma	24.1	BCL2, S100B, TP53, PTEN, EGFR
40	papilloma	23.7	BCL2, S100B, TP53, PTEN, EGFR, GFAP
41	retinitis	23.6	BCL2, S100B, TP53, PTEN, EGFR, GFAP
42	immunodeficiency	23.5	BCL2, S100B, TP53, PTEN, EGFR, GFAP
43	colon cancer	23.1	BCL2, S100B, TP53, PTEN, EGFR
44	melanoma	23.0	BCL2, S100B, MRI1, TP53, PTEN, EGFR
45	papillary ependymoma	13.4	S100B, GFAP
46	choroid plexus carcinoma	13.4	S100B, GFAP
47	anaplastic ganglioglioma	13.4	S100B, GFAP
48	cellular schwannoma	13.4	S100B, GFAP
49	choroid plexus papilloma	13.4	S100B, GFAP
50	chordoid meningioma	13.4	S100B, GFAP

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 cisplatin, cisplatin pwdr [va product], temozolomide

MGI Mouse Phenotypes related to gemistocytic astrocytoma:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	pigmentation phenotype	MP:0001186	8.3	BCL2, TP53, PTEN, EGFR
2	adipose tissue phenotype	MP:0005375	8.0	BCL2, TP53, PTEN, EGFR
3	vision/eye phenotype	MP:0005391	7.9	GFAP, EGFR, PTEN, TP53, BCL2
4	digestive/alimentary phenotype	MP:0005381	7.9	GFAP, EGFR, PTEN, TP53, BCL2
5	muscle phenotype	MP:0005369	7.8	GFAP, EGFR, PTEN, TP53, BCL2
6	endocrine/exocrine gland phenotype	MP:0005379	7.7	BCL2, TP53, PTEN, EGFR, SYCP3
7	integument phenotype	MP:0010771	7.5	EGFR, PTEN, TP53, S100B, BCL2

Articles related to gemistocytic astrocytoma:

id	Title	Authors	Year	Affiliating Genes
1	Gemistocytic astrocytomas: histomorphology, proliferative potential and genetic alterations--a study of 32 cases. (16614946)	Avninder S.... Sarkar C.	2006	EGFR
2	Genotype-phenotype correlation in gemistocytic astrocytomas. (11152345)	KAPsel S.... Graeber M.B.	2001	TP53
3	p53 and PTEN gene mutations in gemistocytic astrocytomas. (9650746)	Watanabe K.... Ohgaki H.	1998	PTEN
4	Role of gemistocytes in astrocytoma progression. (9042164)	Watanabe K.... Ohgaki H.	1997	TP53, BCL2

Genes related to gemistocytic astrocytoma according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	S100B	S100 calcium binding protein B	11.0
2	GFAP	glial fibrillary acidic protein	11.0
3	PTEN	phosphatase and tensin homolog	11.0	Publications
4	SYCP3	synaptonemal complex protein 3	11.0
5	MRI1	methylthioribose-1-phosphate isomerase homolog (S. cerevisiae)	11.0
6	TSGA10	testis specific, 10	11.0
7	BCL2	B-cell CLL/lymphoma 2	11.0	Publications
8	EGFR	epidermal growth factor receptor	11.0	Publications
9	TP53	tumor protein p53	11.0	Publications

Pathways related to gemistocytic astrocytoma according to GeneDecks:

(show all 17)

id	Pathway	Score	Top Affiliating Genes
1	Pathogenesis of ALS36	9.4	BCL2, TP53
2	Development_EGFR signaling via PIP341	9.2	EGFR, PTEN
3	Small cell lung cancer20	9.2	PTEN, TP53, BCL2
4	p53 Signaling36	9.1	BCL2, TP53, PTEN
5	Endometrial cancer20	9.0	TP53, PTEN, EGFR
6	Signal transduction_PTEN pathway41	9.0	EGFR, PTEN, TP53
7	Signal transduction PTEN pathway10	9.0	EGFR, PTEN, TP53
8	Glioma20	9.0	EGFR, PTEN, TP53
9	Melanoma20	9.0	TP53, PTEN, EGFR
10	Development EGFR signaling via PIP310	9.0	EGFR, PTEN
11	Glioblastoma Multiforme36	8.9	EGFR, PTEN, TP53
12	Focal adhesion20	8.7	BCL2, PTEN, EGFR
13	Mitochondrial Apoptosis36	8.6	EGFR, TP53, BCL2
14	Cellular Apoptosis Pathway36	8.5	BCL2, TP53, EGFR
15	Prostate cancer20	8.4	BCL2, TP53, PTEN, EGFR
16	p53 Mediated Apoptosis36	8.4	EGFR, PTEN, TP53, BCL2
17	Pathways in cancer20	8.3	BCL2, TP53, PTEN, EGFR

Compounds related to gemistocytic astrocytoma according to GeneDecks:

(show top 50)    (show all 55)

id	Compound	Score	Top Affiliating Genes
1	adpribose32	10.3	TP53
2	retinoic acid32 42 18	12.2	S100B, GFAP
3	eosin32	10.1	S100B, GFAP
4	s 10032	10.1	S100B, GFAP
5	2,3-cyclic nucleotide32	10.0	GFAP, S100B
6	reticulin32	10.0	GFAP, S100B
7	hematoxylin32	9.8	GFAP, PTEN, S100B
8	mg 13232 42	10.7	PTEN, EGFR
9	tanshinone iia32	9.7	TP53, BCL2
10	panitumumab32 34 9 9	12.6	PTEN, EGFR
11	10-hydroxycamptothecin32	9.6	TP53, BCL2
12	3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide32	9.6	PTEN, S100B, BCL2
13	7-hydroxystaurosporine32 9 9	11.6	TP53, BCL2
14	dutp32	9.4	GFAP, TP53, BCL2
15	noxa32	9.4	PTEN, TP53, BCL2
16	indole-3-carbinol32	9.4	PTEN, TP53, BCL2
17	chlorambucil32 9 9	11.3	BCL2, TP53
18	z-vad-fmk32 42	10.3	BCL2, TP53
19	quercetin32 42 9 18 9	13.2	BCL2, PTEN, GFAP
20	cytarabine32 34 9 9	12.2	BCL2, TP53, GFAP
21	bcnu32	9.2	GFAP, EGFR, TP53
22	shikonin32	9.2	EGFR, BCL2
23	olomoucine32 42 9 9	12.0	BCL2, TP53
24	etoposide32 42 9 9	12.0	BCL2, S100B, TP53, PTEN
25	topotecan32 9 9	10.9	EGFR, TP53, BCL2
26	suberoylanilide hydroxamic acid32	8.9	BCL2, TP53, EGFR
27	flavopiridol32 9 9	10.9	EGFR, TP53, BCL2
28	carboplatin32 34 9 9	11.9	EGFR, TP53, BCL2
29	arsenite32 18	9.9	PTEN, TP53, BCL2
30	docetaxel32 34 9 9	11.8	EGFR, TP53, BCL2
31	imatinib32 34 9 9	11.8	EGFR, PTEN, S100B, BCL2
32	thymidylate32	8.7	BCL2, TP53, EGFR
33	pd 98,05932	8.7	GFAP, EGFR, PTEN, BCL2
34	genistein32 9 18 9	11.6	GFAP, EGFR, PTEN, BCL2
35	taxane32	8.6	EGFR, PTEN, TP53, BCL2
36	bortezomib32 9 9	10.6	EGFR, PTEN, TP53, BCL2
37	curcumin32	8.6	EGFR, TP53, BCL2
38	gemcitabine32 34 9 9	11.6	BCL2, TP53, PTEN, EGFR
39	5fluorouracil32	8.5	EGFR, PTEN, TP53, BCL2
40	tamoxifen32 34 9 9	11.5	BCL2, TP53, PTEN, EGFR
41	doxorubicin32 34 9 9	11.5	BCL2, TP53, PTEN, EGFR
42	ly29400232	8.5	EGFR, PTEN, TP53, BCL2
43	cisplatin32 34 9 9	11.2	GFAP, EGFR, PTEN, TP53, BCL2
44	cycloheximide32	8.2	BCL2, TP53, PTEN, EGFR, GFAP
45	paclitaxel32 34 9 9	10.9	BCL2, S100B, TP53, PTEN, EGFR, GFAP
46	paraffin32	7.9	GFAP, EGFR, PTEN, TP53, S100B, BCL2
47	progesterone32 42 9 18 9	11.9	GFAP, EGFR, PTEN, TP53, S100B, BCL2
48	vegf32	7.9	GFAP, EGFR, PTEN, TP53, S100B, BCL2
49	estrogen32	7.9	GFAP, EGFR, PTEN, TP53, S100B, BCL2
50	serine32	7.8	GFAP, EGFR, PTEN, TP53, S100B, BCL2

Cellular components related to gemistocytic astrocytoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cell projection	GO:042995	9.2	MRI1, PTEN, GFAP
2	nuclear membrane	GO:031965	8.2	BCL2, EGFR, TSGA10
3	cytoplasm	GO:005737	6.9	GFAP, EGFR, PTEN, TP53, S100B, BCL2

Biological processes related to gemistocytic astrocytoma according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	long-term synaptic potentiation	GO:060291	10.0	GFAP, PTEN
2	learning or memory	GO:007611	9.8	S100B, PTEN
3	B cell lineage commitment	GO:002326	9.6	BCL2, TP53
4	regulation of protein stability	GO:031647	9.6	BCL2, PTEN
5	regulation of mitochondrial membrane permeability	GO:046902	9.6	BCL2, TP53
6	central nervous system development	GO:007417	9.5	S100B, TP53, PTEN
7	T cell differentiation in thymus	GO:033077	9.5	BCL2, TP53
8	release of cytochrome c from mitochondria	GO:001836	9.4	TP53, BCL2
9	cell aging	GO:007569	9.3	BCL2, TP53
10	neuron apoptotic process	GO:051402	9.2	BCL2, TP53
11	digestive tract morphogenesis	GO:048546	9.2	BCL2, EGFR
12	response to gamma radiation	GO:010332	9.0	BCL2, TP53
13	cell proliferation	GO:008283	8.7	EGFR, PTEN, TP53, S100B
14	negative regulation of apoptotic process	GO:043066	8.4	BCL2, TP53, PTEN, EGFR

Molecular functions related to gemistocytic astrocytoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	protein phosphatase 2A binding	GO:051721	9.0	TP53, BCL2
2	enzyme binding	GO:019899	8.8	TP53, PTEN, EGFR
3	identical protein binding	GO:042802	7.6	BCL2, S100B, MRI1, TP53, EGFR