MCID: GMS001
MIFTS: 44

Gemistocytic Astrocytoma malady

Neuronal diseases, Cancer diseases, Rare diseases categories
Download this MalaCard

Summaries for Gemistocytic Astrocytoma

About this section


Fully expand this MalaCard
MalaCards based summary: Gemistocytic Astrocytoma, also known as gemistocytic astrocytic tumor, is related to subependymal giant cell astrocytoma and astrocytoma. An important gene associated with Gemistocytic Astrocytoma is S100B (S100 calcium binding protein B), and among its related pathways are Nuclear signaling by ERBB4 and Androgen receptor signaling pathway. The compounds eosin and s 100 have been mentioned in the context of this disorder. Affiliated tissues include brain and spinal cord, and related mouse phenotypes are pigmentation and digestive/alimentary.

Aliases & Classifications for Gemistocytic Astrocytoma

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 62UMLS, 34MeSH, 39NCIt, 57SNOMED-CT, 63UMLS via Orphanet
See all sources

Gemistocytic Astrocytoma, Aliases & Descriptions:

Name: Gemistocytic Astrocytoma 8 10 44 48 62
 
Gemistocytic Astrocytic Tumor 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology8 DOID:7005
MeSH34 D001254
SNOMED-CT57 73982001
NCIt39 C4321
UMLS via Orphanet63 C0334581

Related Diseases for Gemistocytic Astrocytoma

About this section

Diseases related to Gemistocytic Astrocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1subependymal giant cell astrocytoma31.1GFAP
2astrocytoma30.5EGFR, S100B, TP53, PTEN, GFAP
3giant cell glioblastoma30.3GFAP, PTEN, EGFR
4glioblastoma29.7GFAP, PTEN, TP53, S100B, EGFR
5pineoblastoma10.5GFAP
6turcot syndrome10.5PTEN
7fibrillary astrocytoma10.4
8papilloma10.3TP53
9myxopapillary ependymoma10.3S100B, GFAP
10papillary ependymoma10.3S100B, GFAP
11choroid plexus carcinoma10.3S100B, GFAP
12choroid plexus papilloma10.3S100B, GFAP
13syringoma10.3GFAP, S100B
14pineocytoma10.3GFAP, S100B
15myoepithelioma10.3S100B, GFAP
16gliosarcoma10.3PTEN, GFAP
17hemangioblastoma10.3GFAP, S100B
18gliomatosis cerebri10.3PTEN, GFAP
19ganglioglioma10.3GFAP, S100B
20chordoma10.3GFAP, S100B
21pleomorphic adenoma10.3S100B, GFAP
22paraganglioma10.3GFAP, S100B
23malignant mixed mullerian tumor10.3TP53, S100B
24neurilemmoma10.3S100B, GFAP
25fibrosarcoma10.2
26vasculitis10.2
27li-fraumeni syndrome10.2PTEN, TP53
28leiomyosarcoma10.2S100B, TP53
29endometrial carcinoma10.2TP53, PTEN
30thyroid cancer, anaplastic10.2PTEN, TP53
31anaplastic ependymoma10.1GFAP, PTEN, S100B
32meningioma10.1S100B, PTEN, GFAP
33ganglioneuroma10.1GFAP, PTEN, S100B
34pilocytic astrocytoma10.1S100B, PTEN, GFAP
35tuberous sclerosis10.1GFAP, PTEN, S100B
36malignant peripheral nerve sheath tumor10.1EGFR, S100B
37medulloblastoma10.1GFAP, TP53, S100B
38ductal carcinoma in situ10.1TP53, EGFR
39breast ductal carcinoma10.0TP53, EGFR
40thyroid hurthle cell carcinoma10.0TP53, PTEN
41laryngeal benign neoplasm10.0EGFR, TP53
42bladder carcinoma in situ10.0TP53, EGFR
43ataxia telangiectasia10.0SYCP3, TP53
44esophageal cancer10.0TP53, EGFR
45kidney cancer10.0EGFR, TP53
46ependymoma10.0EGFR, S100B, GFAP
47oral cancer10.0EGFR, TP53
48nasopharynx carcinoma9.9EGFR, TP53
49oligodendroglioma9.9GFAP, PTEN, EGFR
50anaplastic oligodendroglioma9.9EGFR, PTEN, GFAP

Graphical network of the top 20 diseases related to Gemistocytic Astrocytoma:



Diseases related to gemistocytic astrocytoma

Symptoms for Gemistocytic Astrocytoma

About this section

Drugs & Therapeutics for Gemistocytic Astrocytoma

About this section

Drug clinical trials:

Search ClinicalTrials for Gemistocytic Astrocytoma

Search NIH Clinical Center for Gemistocytic Astrocytoma

Genetic Tests for Gemistocytic Astrocytoma

About this section

Anatomical Context for Gemistocytic Astrocytoma

About this section

MalaCards organs/tissues related to Gemistocytic Astrocytoma:

32
Brain, Spinal cord

Animal Models for Gemistocytic Astrocytoma or affiliated genes

About this section

MGI Mouse Phenotypes related to Gemistocytic Astrocytoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.7PTEN, TP53, EGFR
2MP:00053818.3GFAP, PTEN, TP53, EGFR
3MP:00053918.2EGFR, TP53, PTEN, GFAP
4MP:00053698.2GFAP, PTEN, TP53, EGFR
5MP:00053898.1EGFR, SYCP3, TP53, PTEN
6MP:00028738.0EGFR, S100B, TP53, PTEN, GFAP
7MP:00053798.0EGFR, SYCP3, TP53, PTEN
8MP:00107717.9PTEN, TP53, S100B, EGFR

Publications for Gemistocytic Astrocytoma

About this section

Articles related to Gemistocytic Astrocytoma:

(show all 13)
idTitleAuthorsYear
1
Perfusion MR imaging and MR spectroscopy of gemistocytic astrocytoma. (22115534)
2012
2
Unusual synchronous presentation of maxillary sinus fibrosarcoma and gemistocytic astrocytoma with a complication called leukocytoclastic vasculitis: a case report. (19756200)
2009
3
Immunohistochemical features of a feline spinal cord gemistocytic astrocytoma. (18987242)
2008
4
Cytologic characteristics of subependymal giant cell astrocytoma in squash smears: morphometric comparisons with gemistocytic astrocytoma and giant cell glioblastoma. (17536538)
2007
5
Congenital gemistocytic astrocytoma in a fetus. (15864706)
2006
6
Gemistocytic astrocytomas: histomorphology, proliferative potential and genetic alterations--a study of 32 cases. (16614946)
2006
7
November 2003: neonatal female with congenital brain tumor. Congenital gemistocytic astrocytoma. (15193038)
2004
8
Genotype-phenotype correlation in gemistocytic astrocytomas. (11152345)
2001
9
p53 and PTEN gene mutations in gemistocytic astrocytomas. (9650746)
1998
10
Gemistocytic astrocytoma in a one-month-old llama. (2365629)
1990
11
A gemistocytic astrocytoma demonstrated high intensity on MR images. Protein hydration layer. (2398944)
1990
12
Development of Hodgkin's disease in a patient receiving procarbazine, CCNU, and vincristine therapy for a gemistocytic astrocytoma. (626997)
1978
13
Gemistocytic astrocytoma: cytological observations on the rate of hydrolysis of some phosphoric acid esters. (13301910)
1955

Variations for Gemistocytic Astrocytoma

About this section

Expression for genes affiliated with Gemistocytic Astrocytoma

About this section
Expression patterns in normal tissues for genes affiliated with Gemistocytic Astrocytoma

Search GEO for disease gene expression data for Gemistocytic Astrocytoma.

Pathways for genes affiliated with Gemistocytic Astrocytoma

About this section

Pathways related to Gemistocytic Astrocytoma according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7GFAP, S100B
29.4PTEN, EGFR
3
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
9.4EGFR, PTEN
49.2TP53, PTEN
5
Show member pathways
DNA damage response37
9.2TP53, PTEN
69.0TP53, EGFR
7
Show member pathways
9.0EGFR, TP53
8
Show member pathways
9.0TP53, EGFR
9
Show member pathways
9.0EGFR, TP53
109.0EGFR, TP53
118.6GFAP, TP53, EGFR
12
Show member pathways
8.6EGFR, S100B, PTEN, GFAP
13
Show member pathways
8.6PTEN, TP53, EGFR
148.6PTEN, TP53, EGFR
158.6PTEN, TP53, EGFR
16
Show member pathways
8.6PTEN, TP53, EGFR
178.6PTEN, TP53, EGFR
188.6EGFR, TP53, PTEN
198.6EGFR, TP53, PTEN
20
Show member pathways
Signal transduction PTEN pathway60
8.6EGFR, TP53, PTEN
21
Show member pathways
8.6EGFR, TP53, PTEN
228.6EGFR, TP53, PTEN
238.6EGFR, TP53, PTEN
248.6EGFR, TP53, PTEN
25
Show member pathways
Signaling Pathways in Glioblastoma37
8.6EGFR, TP53, PTEN
26
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
8.6EGFR, TP53, PTEN
27
Show member pathways
8.2GFAP, PTEN, TP53, EGFR
28
Show member pathways
7.8GFAP, PTEN, TP53, S100B, EGFR

Compounds for genes affiliated with Gemistocytic Astrocytoma

About this section

Compounds related to Gemistocytic Astrocytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1eosin4410.1S100B, GFAP
2s 1004410.1S100B, GFAP
32,3-cyclic nucleotide4410.1GFAP, S100B
4reticulin4410.1S100B, GFAP
53-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.9S100B, PTEN
6panitumumab44 50 1111.8EGFR, PTEN
7cetuximab44 50 1111.7EGFR, PTEN
8bicalutamide44 61 1111.7EGFR, PTEN
9hematoxylin449.7GFAP, PTEN, S100B
10methionine449.6S100B, PTEN, GFAP
11ethanol44 50 24 1112.6GFAP, PTEN, S100B
12erlotinib44 50 1111.5EGFR, PTEN
13noxa449.5TP53, PTEN
14glycogen44 2410.5GFAP, PTEN, S100B
15crcs449.5TP53, PTEN
16dutp449.4TP53, GFAP
17indole-3-carbinol449.4TP53, PTEN
18imatinib44 50 1111.4EGFR, S100B, PTEN
19temozolomide44 1110.4EGFR, TP53
20sn 3844 6110.4EGFR, TP53
21agar449.4EGFR, PTEN, GFAP
22pd 98,059449.3EGFR, PTEN, GFAP
23aspartate449.2S100B, PTEN, GFAP
24etoposide44 50 61 1112.2PTEN, TP53, S100B
25genistein44 28 61 2 24 1114.2GFAP, PTEN, EGFR
26topotecan44 1110.1EGFR, TP53
27suberoylanilide hydroxamic acid449.1EGFR, TP53
28bcnu449.1GFAP, TP53, EGFR
29taxane449.0EGFR, TP53, PTEN
30testosterone44 61 24 1112.0GFAP, PTEN, S100B, EGFR
31bortezomib44 50 1111.0EGFR, TP53, PTEN
32gemcitabine44 50 1111.0EGFR, TP53, PTEN
33mg 13244 6110.0EGFR, TP53, PTEN
345fluorouracil449.0PTEN, TP53, EGFR
35leucine448.9S100B, PTEN, GFAP
36oxaliplatin44 50 1110.9EGFR, TP53
37tamoxifen44 50 28 1111.9PTEN, TP53, EGFR
38ly294002448.9PTEN, TP53, EGFR
39thymidine44 249.9GFAP, TP53, S100B
40doxorubicin44 50 1110.8EGFR, TP53, PTEN
41arginine448.8S100B, TP53, PTEN, GFAP
42cisplatin44 50 61 1111.6GFAP, PTEN, TP53, EGFR
43cycloheximide448.6GFAP, PTEN, TP53, EGFR
44paclitaxel44 50 1110.2EGFR, S100B, TP53, PTEN, GFAP
45paraffin448.2GFAP, PTEN, TP53, S100B, EGFR
46progesterone44 28 61 24 1112.2GFAP, PTEN, TP53, S100B, EGFR
47vegf448.2EGFR, S100B, TP53, PTEN, GFAP
48estrogen448.2GFAP, PTEN, TP53, S100B, EGFR
49retinoic acid44 249.2EGFR, S100B, TP53, PTEN, GFAP
50serine448.2GFAP, PTEN, TP53, S100B, EGFR

GO Terms for genes affiliated with Gemistocytic Astrocytoma

About this section

Cellular components related to Gemistocytic Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1PML bodyGO:0166059.2TP53, PTEN
2cytoplasmGO:0057377.0EGFR, S100B, TSGA10, TP53, PTEN, GFAP

Biological processes related to Gemistocytic Astrocytoma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1memoryGO:0076139.7S100B, PTEN
2long-term synaptic potentiationGO:0602919.5S100B, PTEN, GFAP
3learning or memoryGO:0076119.2EGFR, S100B, PTEN
4cellular response to drugGO:0356909.1EGFR, TP53
5positive regulation of cell proliferationGO:0082849.0EGFR, S100B, PTEN
6innate immune responseGO:0450879.0EGFR, S100B, PTEN
7central nervous system developmentGO:0074179.0S100B, TP53, PTEN
8cellular response to hypoxiaGO:0714569.0S100B, TP53
9positive regulation of apoptotic processGO:0430659.0PTEN, TP53, S100B
10negative regulation of apoptotic processGO:0430668.5PTEN, TP53, EGFR
11cell proliferationGO:0082838.4PTEN, TP53, S100B, EGFR

Molecular functions related to Gemistocytic Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integrin bindingGO:0051789.4EGFR, GFAP
2protein phosphatase bindingGO:0199038.9TP53, EGFR
3enzyme bindingGO:0198998.6EGFR, TP53, PTEN
4protein kinase bindingGO:0199018.6EGFR, TP53, PTEN
5identical protein bindingGO:0428028.4EGFR, S100B, TP53

Products for genes affiliated with Gemistocytic Astrocytoma

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Gemistocytic Astrocytoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet