MCID: GMS001
MIFTS: 44

Gemistocytic Astrocytoma malady

Neuronal diseases, Cancer diseases, Rare diseases categories

Summaries for Gemistocytic Astrocytoma

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34MalaCards
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MalaCards: Gemistocytic Astrocytoma, also known as gemistocytic astrocytic tumor, is related to astrocytoma and subependymal giant cell astrocytoma. An important gene associated with Gemistocytic Astrocytoma is S100B (S100 calcium binding protein B), and among its related pathways are Nuclear signaling by ERBB4 and Androgen receptor signaling pathway. The compounds eosin and s 100 have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and thyroid, and related mouse phenotypes are pigmentation and digestive/alimentary.

Aliases & Classifications for Gemistocytic Astrocytoma

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9Disease Ontology, 11DISEASES, 46Novoseek, 50Orphanet, 63UMLS, 36MeSH, 41NCIt, 59SNOMED-CT, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

gemistocytic astrocytoma 9 11 46 50 63
gemistocytic astrocytic tumor 9


External Ids:

Disease Ontology9 DOID:7005
MeSH36 D001254
NCIt41 C4321
SNOMED-CT59 73982001
SNOMED-CT via Orphanet60 73982001
UMLS via Orphanet64 C0334581

Related Diseases for Gemistocytic Astrocytoma

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18GeneCards, 19GeneDecks
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Diseases related to Gemistocytic Astrocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
1astrocytoma31.0EGFR, S100B, TP53, PTEN, GFAP
2subependymal giant cell astrocytoma30.5GFAP
3giant cell glioblastoma30.3GFAP, PTEN, EGFR
4diffuse astrocytoma10.4
5fibrosarcoma10.2
6papillary thyroid carcinoma10.2
7thyroiditis10.2
8vasculitis10.2
9pineoblastoma10.1GFAP
10turcot syndrome10.1PTEN
11papilloma10.1TP53
12myxopapillary ependymoma10.1S100B, GFAP
13papillary ependymoma10.1S100B, GFAP
14choroid plexus carcinoma10.1S100B, GFAP
15choroid plexus papilloma10.1S100B, GFAP
16syringoma10.1GFAP, S100B
17pineocytoma10.1GFAP, S100B
18myoepithelioma10.1S100B, GFAP
19gliosarcoma10.1PTEN, GFAP
20hemangioblastoma10.1GFAP, S100B
21gliomatosis cerebri10.1PTEN, GFAP
22ganglioglioma10.1GFAP, S100B
23chordoma10.1GFAP, S100B
24pleomorphic adenoma10.1S100B, GFAP
25paraganglioma10.1GFAP, S100B
26malignant mixed mullerian tumor10.1TP53, S100B
27neurilemmoma10.1S100B, GFAP
28li-fraumeni syndrome10.0PTEN, TP53
29leiomyosarcoma10.0S100B, TP53
30endometrial carcinoma10.0TP53, PTEN
31thyroid cancer, anaplastic10.0PTEN, TP53
32anaplastic ependymoma10.0GFAP, PTEN, S100B
33meningioma10.0S100B, PTEN, GFAP
34ganglioneuroma10.0GFAP, PTEN, S100B
35pilocytic astrocytoma10.0S100B, PTEN, GFAP
36tuberous sclerosis10.0GFAP, PTEN, S100B
37malignant peripheral nerve sheath tumor10.0EGFR, S100B
38medulloblastoma10.0GFAP, TP53, S100B
39ductal carcinoma in situ10.0TP53, EGFR
40thyroid cancer10.0TP53, PTEN
41laryngeal benign neoplasm10.0EGFR, TP53
42bladder carcinoma in situ10.0TP53, EGFR
43ataxia telangiectasia10.0SYCP3, TP53
44esophageal cancer10.0TP53, EGFR
45kidney cancer10.0EGFR, TP53
46ependymoma10.0EGFR, S100B, GFAP
47oral cancer10.0EGFR, TP53
48oligodendroglioma10.0GFAP, PTEN, EGFR
49anaplastic oligodendroglioma10.0EGFR, PTEN, GFAP
50nasopharynx carcinoma10.0EGFR, TP53

Graphical network of the top 20 diseases related to Gemistocytic Astrocytoma:



Diseases related to gemistocytic astrocytoma

Symptoms for Gemistocytic Astrocytoma

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Drugs & Therapeutics for Gemistocytic Astrocytoma

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Gemistocytic Astrocytoma

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Anatomical Context for Gemistocytic Astrocytoma

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34MalaCards
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MalaCards organs/tissues related to Gemistocytic Astrocytoma:

34
Brain, Spinal cord, Thyroid

Animal Models for Gemistocytic Astrocytoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Gemistocytic Astrocytoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.7PTEN, TP53, EGFR
2MP:00053818.3GFAP, PTEN, TP53, EGFR
3MP:00053918.2EGFR, TP53, PTEN, GFAP
4MP:00053698.2GFAP, PTEN, TP53, EGFR
5MP:00053898.1EGFR, SYCP3, TP53, PTEN
6MP:00028738.0EGFR, S100B, TP53, PTEN, GFAP
7MP:00053798.0EGFR, SYCP3, TP53, PTEN
8MP:00107717.9PTEN, TP53, S100B, EGFR

Publications for Gemistocytic Astrocytoma

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53PubMed
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Articles related to Gemistocytic Astrocytoma:

(show all 14)
idTitleAuthorsYear
1
Perfusion MR imaging and MR spectroscopy of gemistocytic astrocytoma. (22115534)
2012
2
Unusual synchronous presentation of maxillary sinus fibrosarcoma and gemistocytic astrocytoma with a complication called leukocytoclastic vasculitis: a case report. (19756200)
2009
3
Immunohistochemical features of a feline spinal cord gemistocytic astrocytoma. (18987242)
2008
4
Cytologic characteristics of subependymal giant cell astrocytoma in squash smears: morphometric comparisons with gemistocytic astrocytoma and giant cell glioblastoma. (17536538)
2007
5
Congenital gemistocytic astrocytoma in a fetus. (15864706)
2006
6
Gemistocytic astrocytomas: histomorphology, proliferative potential and genetic alterations--a study of 32 cases. (16614946)
2006
7
November 2003: neonatal female with congenital brain tumor. Congenital gemistocytic astrocytoma. (15193038)
2004
8
Genotype-phenotype correlation in gemistocytic astrocytomas. (11152345)
2001
9
p53 and PTEN gene mutations in gemistocytic astrocytomas. (9650746)
1998
10
Multiple primary malignant tumours: gemistocytic astrocytoma with leptomeningeal spreading and papillary thyroid carcinoma. A case report. (2251958)
1990
11
Gemistocytic astrocytoma in a one-month-old llama. (2365629)
1990
12
A gemistocytic astrocytoma demonstrated high intensity on MR images. Protein hydration layer. (2398944)
1990
13
Development of Hodgkin's disease in a patient receiving procarbazine, CCNU, and vincristine therapy for a gemistocytic astrocytoma. (626997)
1978
14
Gemistocytic astrocytoma: cytological observations on the rate of hydrolysis of some phosphoric acid esters. (13301910)
1955

Variations for Gemistocytic Astrocytoma

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Expression for genes affiliated with Gemistocytic Astrocytoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gemistocytic Astrocytoma

Search GEO for disease gene expression data for Gemistocytic Astrocytoma.

Pathways for genes affiliated with Gemistocytic Astrocytoma

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51PathCards, 56Reactome, 39NCBI BioSystems Database, 61Thomson Reuters, 31KEGG, 54QIAGEN, 58SinoBiological, 62Tocris Bioscience, 55R&D Systems
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Pathways related to Gemistocytic Astrocytoma according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7S100B, GFAP
29.4EGFR, PTEN
3
Show member pathways
Translation Non genomic rapid action of Androgen Receptor61
9.4EGFR, PTEN
4
Show member pathways
DNA damage response39
9.2PTEN, TP53
59.2TP53, PTEN
6
Show member pathways
9.0EGFR, TP53
79.0TP53, EGFR
8
Show member pathways
9.0EGFR, TP53
9
Show member pathways
9.0TP53, EGFR
109.0TP53, EGFR
118.6EGFR, TP53, GFAP
12
Show member pathways
8.6EGFR, S100B, PTEN, GFAP
138.6PTEN, TP53, EGFR
14
Show member pathways
Signal transduction PTEN pathway61
8.6TP53, PTEN, EGFR
15
Show member pathways
8.6PTEN, TP53, EGFR
168.6PTEN, TP53, EGFR
178.6TP53, PTEN, EGFR
18
Show member pathways
8.6PTEN, TP53, EGFR
19
Show member pathways
8.6PTEN, TP53, EGFR
208.6EGFR, PTEN, TP53
218.6EGFR, TP53, PTEN
228.6EGFR, TP53, PTEN
238.6PTEN, EGFR, TP53
24
Show member pathways
Development EGFR signaling via PIP361
Development PDGF signaling via MAPK cascades61
Apoptosis and survival Anti apoptotic action of membrane bound ESR161
Signaling of Hepatocyte Growth Factor Receptor39
Development EGFR signaling via small GTPases61
Development Neurotrophin family signaling61
Apoptosis and survival NGF signaling pathway61
Apoptosis and survival Role of CDK5 in neuronal death and survival61
8.6EGFR, TP53, PTEN
258.6EGFR, PTEN, TP53
26
Show member pathways
Signaling Pathways in Glioblastoma39
8.6EGFR, TP53, PTEN
27
Show member pathways
8.2EGFR, TP53, GFAP, PTEN
28
Show member pathways
7.8TP53, PTEN, GFAP, S100B, EGFR

Compounds for genes affiliated with Gemistocytic Astrocytoma

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 25HMDB, 30IUPHAR, 3BitterDB
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Compounds related to Gemistocytic Astrocytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1eosin4610.1S100B, GFAP
2s 1004610.1S100B, GFAP
32,3-cyclic nucleotide4610.1S100B, GFAP
4reticulin4610.1S100B, GFAP
53-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide469.8PTEN, S100B
6panitumumab46 52 1211.8PTEN, EGFR
7cetuximab46 52 1211.7EGFR, PTEN
8bicalutamide46 62 1211.7PTEN, EGFR
9hematoxylin469.7PTEN, S100B, GFAP
10methionine469.6GFAP, PTEN, S100B
11ethanol46 52 25 1212.6S100B, GFAP, PTEN
12noxa469.5TP53, PTEN
13erlotinib46 52 1211.5PTEN, EGFR
14glycogen46 2510.5GFAP, S100B, PTEN
15crcs469.5TP53, PTEN
16dutp469.5GFAP, TP53
17indole-3-carbinol469.4TP53, PTEN
18imatinib46 52 1211.4EGFR, S100B, PTEN
19temozolomide46 1210.4TP53, EGFR
20sn 3846 6210.4EGFR, TP53
21agar469.4GFAP, PTEN, EGFR
22pd 98,059469.3GFAP, PTEN, EGFR
23aspartate469.2GFAP, PTEN, S100B
24etoposide46 52 62 1212.2S100B, PTEN, TP53
25topotecan46 1210.2TP53, EGFR
26genistein46 30 62 3 25 1214.2PTEN, EGFR, GFAP
27suberoylanilide hydroxamic acid469.1TP53, EGFR
28bcnu469.1GFAP, TP53, EGFR
29taxane469.0PTEN, TP53, EGFR
30testosterone46 62 25 1212.0PTEN, S100B, GFAP, EGFR
31bortezomib46 52 1211.0PTEN, EGFR, TP53
32gemcitabine46 52 1211.0PTEN, TP53, EGFR
33mg 13246 6210.0TP53, EGFR, PTEN
345fluorouracil469.0PTEN, TP53, EGFR
35leucine468.9S100B, PTEN, GFAP
36oxaliplatin46 52 1210.9EGFR, TP53
37tamoxifen46 52 30 1211.9PTEN, TP53, EGFR
38ly294002468.9PTEN, TP53, EGFR
39thymidine46 259.9TP53, S100B, GFAP
40doxorubicin46 52 1210.8TP53, PTEN, EGFR
41arginine468.8S100B, TP53, PTEN, GFAP
42cisplatin46 52 62 1211.6EGFR, GFAP, PTEN, TP53
43cycloheximide468.6GFAP, PTEN, TP53, EGFR
44paclitaxel46 52 1210.2PTEN, S100B, EGFR, TP53, GFAP
45paraffin468.2EGFR, TP53, PTEN, GFAP, S100B
46progesterone46 30 62 25 1212.2GFAP, EGFR, S100B, TP53, PTEN
47vegf468.2GFAP, PTEN, TP53, S100B, EGFR
48estrogen468.2PTEN, S100B, TP53, EGFR, GFAP
49retinoic acid46 259.2EGFR, GFAP, S100B, TP53, PTEN
50serine468.2EGFR, S100B, TP53, PTEN, GFAP

GO Terms for genes affiliated with Gemistocytic Astrocytoma

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17Gene Ontology
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Cellular components related to Gemistocytic Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1PML bodyGO:0166059.2TP53, PTEN
2cytoplasmGO:0057377.0EGFR, S100B, TSGA10, TP53, PTEN, GFAP

Biological processes related to Gemistocytic Astrocytoma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1memoryGO:0076139.7S100B, PTEN
2long-term synaptic potentiationGO:0602919.5S100B, PTEN, GFAP
3learning or memoryGO:0076119.2EGFR, S100B, PTEN
4cellular response to drugGO:0356909.1EGFR, TP53
5positive regulation of cell proliferationGO:0082849.0EGFR, S100B, PTEN
6innate immune responseGO:0450879.0EGFR, S100B, PTEN
7central nervous system developmentGO:0074179.0S100B, TP53, PTEN
8cellular response to hypoxiaGO:0714569.0S100B, TP53
9positive regulation of apoptotic processGO:0430659.0PTEN, TP53, S100B
10negative regulation of apoptotic processGO:0430668.5PTEN, TP53, EGFR
11cell proliferationGO:0082838.4PTEN, TP53, S100B, EGFR

Molecular functions related to Gemistocytic Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integrin bindingGO:0051789.4EGFR, GFAP
2protein phosphatase bindingGO:0199038.9TP53, EGFR
3enzyme bindingGO:0198998.6EGFR, TP53, PTEN
4protein kinase bindingGO:0199018.6EGFR, TP53, PTEN
5identical protein bindingGO:0428028.4EGFR, S100B, TP53

Products for genes affiliated with Gemistocytic Astrocytoma

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  • Antibodies
  • Proteins
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Sources for Gemistocytic Astrocytoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet