MCID: GMS001
MIFTS: 45

Gemistocytic Astrocytoma malady

Neuronal diseases, Cancer diseases categories

Summaries for Gemistocytic Astrocytoma

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32MalaCards
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MalaCards: Gemistocytic Astrocytoma, also known as gemistocytic astrocytic tumor, is related to astrocytoma and subependymal giant cell astrocytoma. An important gene associated with Gemistocytic Astrocytoma is S100B (S100 calcium binding protein B), and among its related pathways are Glioma and TP53 network. The compounds eosin and s 100 have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and thyroid, and related mouse phenotypes are muscle and pigmentation.

Aliases & Classifications for Gemistocytic Astrocytoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

gemistocytic astrocytoma 8 10 44 48 60
gemistocytic astrocytic tumor 8


External Ids:

Disease Ontology8 DOID:7005
MeSH34 D001254
SNOMED-CT56 73982001
NCIt39 C4321
SNOMED-CT via Orphanet57 73982001

Related Diseases for Gemistocytic Astrocytoma

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17GeneCards, 18GeneDecks
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Diseases related to Gemistocytic Astrocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 104)
idRelated DiseaseScoreTop Affiliating Genes
1astrocytoma31.1S100B, EGFR, GFAP, PTEN, TP53
2subependymal giant cell astrocytoma30.2GFAP
3giant cell glioblastoma30.2EGFR, GFAP, PTEN
4diffuse astrocytoma10.3
5papillary carcinoma10.2
6spinal cord astrocytoma10.2
7fibrosarcoma10.2
8papillary thyroid carcinoma10.2
9thyroiditis10.2
10vasculitis10.2
11gastrointestinal stromal tumor10.0S100B
12leiomyoma10.0S100B
13granular cell tumor10.0S100B
14ganglioneuroblastoma10.0S100B
15teratoma10.0GFAP
16smooth muscle tumor10.0S100B
17chondrosarcoma10.0S100B
18neurofibroma10.0S100B
19prion disease10.0GFAP
20peutz-jeghers syndrome10.0PTEN
21ischemia10.0GFAP
22amyotrophic lateral sclerosis10.0GFAP
23pineoblastoma10.0GFAP
24turcot syndrome10.0PTEN
25papilloma10.0TP53
26endometriosis10.0PTEN
27gallbladder cancer10.0TP53
28dementia10.0GFAP
29neuroblastoma10.0TP53
30osteosarcoma10.0TP53
31nephroblastoma10.0TP53
32adrenocortical carcinoma10.0TP53
33xeroderma pigmentosum10.0TP53
34liposarcoma10.0TP53
35azoospermia10.0SYCP3
36paraganglioma10.0GFAP, S100B
37hemangioblastoma10.0S100B, GFAP
38chordoma10.0GFAP, S100B
39myoepithelioma10.0GFAP, S100B
40myxopapillary ependymoma10.0S100B, GFAP
41familial adenomatous polyposis10.0TP53
42ganglioglioma10.0GFAP, S100B
43papillary ependymoma10.0GFAP, S100B
44gliosarcoma10.0PTEN, GFAP
45choroid plexus carcinoma10.0GFAP, S100B
46gliomatosis cerebri10.0PTEN, GFAP
47choroid plexus papilloma10.0S100B, GFAP
48pineocytoma10.0S100B, GFAP
49benign mesothelioma10.0TP53
50alzheimer's disease10.0GFAP, S100B

Graphical network of the top 20 diseases related to Gemistocytic Astrocytoma:



Diseases related to gemistocytic astrocytoma

Clinical Features for Gemistocytic Astrocytoma

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Drugs & Therapeutics for Gemistocytic Astrocytoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Gemistocytic Astrocytoma

Drug clinical trials:

Search ClinicalTrials for Gemistocytic Astrocytoma

Search NIH Clinical Center for Gemistocytic Astrocytoma

Search CenterWatch for Gemistocytic Astrocytoma

Genetic Tests for Gemistocytic Astrocytoma

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Anatomical Context for Gemistocytic Astrocytoma

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32MalaCards
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MalaCards organs/tissues related to Gemistocytic Astrocytoma:

32
Brain, Spinal cord, Thyroid

Animal Models for Gemistocytic Astrocytoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Gemistocytic Astrocytoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053699.6TP53, GFAP
2MP:00011868.7TP53, BCL2, PTEN, EGFR
3MP:00028738.3TP53, PTEN, GFAP, EGFR, S100B
4MP:00053818.3EGFR, GFAP, PTEN, BCL2, TP53
5MP:00053918.2EGFR, GFAP, PTEN, BCL2, TP53
6MP:00053798.0TP53, BCL2, PTEN, SYCP3, EGFR
7MP:00107717.9S100B, EGFR, PTEN, BCL2, TP53

Publications for Gemistocytic Astrocytoma

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50PubMed
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Articles related to Gemistocytic Astrocytoma:

(show all 16)
idTitleAuthorsYear
1
Perfusion MR imaging and MR spectroscopy of gemistocytic astrocytoma. (22115534)
2012
2
Pilocytic astrocytoma with neoplastic gemistocytes undergoing spontaneous transformation to glioblastoma multiforme without prior radiotherapy. (21349721)
2011
3
Unusual synchronous presentation of maxillary sinus fibrosarcoma and gemistocytic astrocytoma with a complication called leukocytoclastic vasculitis: a case report. (19756200)
2009
4
Immunohistochemical features of a feline spinal cord gemistocytic astrocytoma. (18987242)
2008
5
Cytologic characteristics of subependymal giant cell astrocytoma in squash smears: morphometric comparisons with gemistocytic astrocytoma and giant cell glioblastoma. (17536538)
2007
6
Congenital gemistocytic astrocytoma in a fetus. (15864706)
2006
7
Gemistocytic astrocytomas: histomorphology, proliferative potential and genetic alterations--a study of 32 cases. (16614946)
2006
8
November 2003: neonatal female with congenital brain tumor. Congenital gemistocytic astrocytoma. (15193038)
2004
9
Genotype-phenotype correlation in gemistocytic astrocytomas. (11152345)
2001
10
p53 and PTEN gene mutations in gemistocytic astrocytomas. (9650746)
1998
11
Role of gemistocytes in astrocytoma progression. (9042164)
1997
12
Multiple primary malignant tumours: gemistocytic astrocytoma with leptomeningeal spreading and papillary thyroid carcinoma. A case report. (2251958)
1990
13
Gemistocytic astrocytoma in a one-month-old llama. (2365629)
1990
14
A gemistocytic astrocytoma demonstrated high intensity on MR images. Protein hydration layer. (2398944)
1990
15
Development of Hodgkin's disease in a patient receiving procarbazine, CCNU, and vincristine therapy for a gemistocytic astrocytoma. (626997)
1978
16
Gemistocytic astrocytoma: cytological observations on the rate of hydrolysis of some phosphoric acid esters. (13301910)
1955

Genetic Variations for Gemistocytic Astrocytoma

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Expression for genes affiliated with Gemistocytic Astrocytoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gemistocytic Astrocytoma

Search GEO for disease gene expression data for Gemistocytic Astrocytoma.

Pathways for genes affiliated with Gemistocytic Astrocytoma

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Sources:
29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 53Reactome, 52R&D Systems, 59Tocris Bioscience, 12EMD Millipore
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Pathways related to Gemistocytic Astrocytoma according to GeneCards/GeneDecks:

(show all 27)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.9TP53
29.4TP53, BCL2
3
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9.4TP53, BCL2
4
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9.4TP53, BCL2
5
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9.4TP53, BCL2
69.3TP53, EGFR
7
Hide members
9.0TP53, BCL2, PTEN
89.0PTEN, BCL2, TP53
9
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9.0PTEN, BCL2, TP53
109.0PTEN, BCL2, TP53
11
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9.0PTEN, BCL2, TP53
129.0EGFR, GFAP, TP53
139.0EGFR, PTEN, TP53
149.0TP53, PTEN, EGFR
15
Hide members
8.9S100B, EGFR, GFAP, PTEN
16
Hide members
8.9TP53, BCL2, EGFR
178.5EGFR, PTEN, BCL2, TP53
188.5EGFR, PTEN, BCL2, TP53
198.5EGFR, PTEN, BCL2, TP53
20
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8.5EGFR, PTEN, BCL2, TP53
21
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8.5EGFR, PTEN, BCL2, TP53
228.5EGFR, PTEN, BCL2, TP53
238.5TP53, BCL2, PTEN, EGFR
248.5TP53, BCL2, PTEN, EGFR
25
Hide members
8.5TP53, BCL2, PTEN, EGFR
26
Hide members
8.5TP53, BCL2, PTEN, EGFR
27
Hide members
8.2EGFR, GFAP, PTEN, BCL2, TP53

Compounds for genes affiliated with Gemistocytic Astrocytoma

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44Novoseek, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 24HMDB, 28IUPHAR, 2BitterDB
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Compounds related to Gemistocytic Astrocytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 68)
idCompoundScoreTop Affiliating Genes
1eosin4410.1GFAP, S100B
2s 1004410.1S100B, GFAP
3etoposide44 49 59 1113.1S100B, BCL2
42,3-cyclic nucleotide4410.0S100B, GFAP
5panitumumab44 49 1111.9PTEN, EGFR
6reticulin449.9GFAP, S100B
7ly294002449.8BCL2, EGFR
8hematoxylin449.8PTEN, GFAP, S100B
9tanshinone iia449.8BCL2, TP53
103-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.7S100B, PTEN, BCL2
1110-hydroxycamptothecin449.7TP53, BCL2
127-hydroxystaurosporine44 1110.6BCL2, TP53
13shikonin449.6BCL2, EGFR
14dutp449.5GFAP, BCL2, TP53
15quercetin44 59 11 2412.4GFAP, PTEN, BCL2
16noxa449.4PTEN, BCL2, TP53
17indole-3-carbinol449.4PTEN, BCL2, TP53
18bcnu449.4EGFR, GFAP, TP53
19cytarabine44 49 1111.3TP53, BCL2, GFAP
20topotecan44 1110.3EGFR, BCL2, TP53
21suberoylanilide hydroxamic acid449.3TP53, BCL2, EGFR
22flavopiridol44 1110.3EGFR, BCL2, TP53
23imatinib44 49 1111.2BCL2, PTEN, EGFR, S100B
24carboplatin44 49 1111.2EGFR, BCL2, TP53
25cyclophosphamide44 49 1111.2PTEN, BCL2, TP53
26adpribose449.2EGFR, BCL2, TP53
27thymidylate449.1EGFR, BCL2, TP53
28pd 98,059449.1EGFR, GFAP, PTEN, BCL2
29docetaxel44 49 59 1112.1TP53, BCL2, EGFR
30chlorambucil44 1110.1BCL2, TP53
31genistein44 28 59 2 11 2414.1BCL2, PTEN, GFAP, EGFR
32taxane449.0EGFR, PTEN, BCL2, TP53
33bortezomib44 119.9TP53, BCL2, PTEN, EGFR
34gemcitabine44 49 1110.9EGFR, PTEN, BCL2, TP53
35mg 13244 599.9EGFR, PTEN, BCL2, TP53
36arsenite44 249.9TP53, BCL2, PTEN
37testosterone44 59 11 2411.9PTEN, GFAP, EGFR, S100B
385fluorouracil448.9TP53, BCL2, PTEN, EGFR
39tamoxifen44 49 28 1111.9TP53, BCL2, PTEN, EGFR
40curcumin448.9EGFR, BCL2, TP53
41doxorubicin44 49 1110.8TP53, BCL2, PTEN, EGFR
42cisplatin44 49 59 1111.6EGFR, GFAP, PTEN, BCL2, TP53
43cycloheximide448.6TP53, BCL2, PTEN, GFAP, EGFR
44paclitaxel44 49 1110.3TP53, BCL2, PTEN, GFAP, EGFR, S100B
45paraffin448.3S100B, EGFR, GFAP, PTEN, BCL2, TP53
46progesterone44 59 28 11 2412.3S100B, EGFR, GFAP, PTEN, BCL2, TP53
47vegf448.3S100B, EGFR, GFAP, PTEN, BCL2, TP53
48estrogen448.3S100B, EGFR, GFAP, PTEN, BCL2, TP53
49retinoic acid44 249.3S100B, EGFR, GFAP, PTEN, BCL2, TP53
50serine448.2S100B, EGFR, GFAP, PTEN, BCL2, TP53

GO Terms for genes affiliated with Gemistocytic Astrocytoma

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16Gene Ontology
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Cellular components related to Gemistocytic Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear membraneGO:0319659.0BCL2, TSGA10, EGFR
2cytoplasmGO:0057376.2TP53, S100B, MRI1, EGFR, GFAP, PTEN

Biological processes related to Gemistocytic Astrocytoma according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1learning or memoryGO:0076119.8PTEN, S100B
2long-term synaptic potentiationGO:0602919.7PTEN, GFAP, S100B
3digestive tract morphogenesisGO:0485469.7BCL2, EGFR
4B cell lineage commitmentGO:0023269.7TP53, BCL2
5regulation of mitochondrial membrane permeabilityGO:0469029.7TP53, BCL2
6regulation of protein stabilityGO:0316479.6BCL2, PTEN
7release of cytochrome c from mitochondriaGO:0018369.6TP53, BCL2
8cell agingGO:0075699.5TP53, BCL2
9positive regulation of intrinsic apoptotic signaling pathwayGO:20012449.5TP53, BCL2
10response to gamma radiationGO:0103329.5BCL2, TP53
11central nervous system developmentGO:0074179.4S100B, PTEN, TP53
12T cell differentiation in thymusGO:0330779.3TP53, BCL2
13neuron apoptotic processGO:0514029.1TP53, BCL2
14innate immune responseGO:0450879.0S100B, EGFR, PTEN, BCL2
15cell proliferationGO:0082838.9S100B, EGFR, PTEN, TP53
16negative regulation of apoptotic processGO:0430668.7EGFR, PTEN, BCL2, TP53

Molecular functions related to Gemistocytic Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein phosphatase 2A bindingGO:0517219.1BCL2, TP53
2enzyme bindingGO:0198999.0TP53, PTEN, EGFR
3identical protein bindingGO:0428027.6TP53, BCL2, EGFR, MRI1, S100B

Products for genes affiliated with Gemistocytic Astrocytoma

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Sources for Gemistocytic Astrocytoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet