MCID: GMS001
MIFTS: 33

Gemistocytic Astrocytoma malady

Categories: Neuronal diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Gemistocytic Astrocytoma

Aliases & Descriptions for Gemistocytic Astrocytoma:

Name: Gemistocytic Astrocytoma 12 56 52 14 69
Gemistocytic Astrocytic Tumor 12

Classifications:

Orphanet: 56  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:7005
MeSH 42 D001254
NCIt 47 C4321
SNOMED-CT 64 73982001
Orphanet 56 ORPHA251604
UMLS via Orphanet 70 C0334581
ICD10 via Orphanet 34 C71.9
UMLS 69 C0334581

Summaries for Gemistocytic Astrocytoma

MalaCards based summary : Gemistocytic Astrocytoma, also known as gemistocytic astrocytic tumor, is related to fibrillary astrocytoma and astrocytoma, and has symptoms including headache, seizures and motor manifestations. An important gene associated with Gemistocytic Astrocytoma is IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2, Mitochondrial), and among its related pathways/superpathways are Signaling by ERBB4 and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Histamine and Cyproheptadine have been mentioned in the context of this disorder. Affiliated tissues include brain, thyroid and spinal cord, and related phenotype is Decreased shRNA abundance (Z-score < -2).

Related Diseases for Gemistocytic Astrocytoma

Diseases related to Gemistocytic Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
id Related Disease Score Top Affiliating Genes
1 fibrillary astrocytoma 11.2
2 astrocytoma 10.5
3 cystic lymphangioma 10.1 IDH2 PTEN
4 epidermal appendage tumor 10.1 GFAP PTEN
5 ophn1 syndrome 10.1 GFAP IDH2
6 childhood embryonal testis carcinoma 10.1 GFAP PTEN
7 bile duct clear cell adenocarcinoma 10.1 GFAP IDH2
8 focal cortical dysplasia, taylor balloon cell type 10.1 GFAP PTEN
9 amyloid tumor 10.1 GFAP IDH2
10 pineal dysgerminoma 10.1 GFAP PTEN
11 lupus - neurological sequelae 10.0 PTEN S100B
12 early myoclonic encephalopathy 10.0 GFAP PTEN
13 monkeypox 10.0 PTEN S100B
14 marginal zone b-cell lymphoma 10.0 GFAP PTEN
15 monostotic fibrous dysplasia 10.0 PTEN S100B
16 myelinoclastic diffuse sclerosis 10.0 GFAP S100B
17 neurological consequences of cytomegalovirus infection 10.0 PTEN S100B
18 tetanus neonatorum 10.0 GFAP PTEN
19 spleen angiosarcoma 10.0 GFAP S100B
20 ovarian cystadenoma 10.0 GFAP S100B
21 trombiculiasis 10.0 GFAP S100B
22 biliary papillomatosis 10.0 GFAP S100B
23 microinvasive cervical squamous cell carcinoma 10.0 GFAP S100B
24 adenofibroma 10.0 GFAP S100B
25 porokeratosis 10.0 GFAP S100B
26 behcet's syndrome arthropathy 10.0 GFAP S100B
27 sternum cancer 10.0 GFAP S100B
28 vulvar squamous papilloma 9.9 GFAP S100B
29 hypogonadotropic hypogonadism-retinitis pigmentosa syndrome 9.9 GFAP S100B
30 glomeruloid hemangioma 9.9 GFAP PTEN
31 piussan lenaerts mathieu syndrome 9.9 GFAP S100B
32 auricular cancer 9.9 GFAP S100B
33 skin glomus tumor 9.9 GFAP S100B
34 pediculus humanus corporis infestation 9.9 GFAP S100B
35 urea cycle disorder 9.9 GFAP S100B
36 inner ear cancer 9.9 GFAP S100B
37 central nervous system hemangioma 9.9 GFAP S100B
38 interstitial lung disease 9.9 GFAP IDH2 PTEN
39 adult oligodendroglioma 9.9 GFAP IDH2 PTEN
40 breast reconstruction 9.9 GFAP S100B
41 nodular goiter 9.9 GFAP PTEN
42 c-p angle neurinoma 9.9 GFAP S100B
43 granular cell leiomyosarcoma 9.9 GFAP S100B
44 epimetaphyseal dysplasia cataract 9.9 GFAP S100B
45 connective tissue cancer 9.9 GFAP S100B
46 giant cell glioblastoma 9.9
47 fibrosarcoma 9.9
48 subependymal giant cell astrocytoma 9.9
49 thyroiditis 9.9
50 vasculitis 9.9

Graphical network of the top 20 diseases related to Gemistocytic Astrocytoma:



Diseases related to Gemistocytic Astrocytoma

Symptoms & Phenotypes for Gemistocytic Astrocytoma

UMLS symptoms related to Gemistocytic Astrocytoma:


headache, seizures, motor manifestations, sensory manifestations

GenomeRNAi Phenotypes related to Gemistocytic Astrocytoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.17 S100B
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.17 S100B
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.17 S100B
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.17 S100B
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 9.17 PTEN S100B
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.17 PTEN

Drugs & Therapeutics for Gemistocytic Astrocytoma

Drugs for Gemistocytic Astrocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
2
Cyproheptadine Approved Phase 3 129-03-3 2913
3 Dermatologic Agents Phase 3,Phase 1
4
Histamine Phosphate Phase 3 51-74-1 65513
5
Serotonin Phase 3 50-67-9 5202
6 Serotonin Agents Phase 3
7 Serotonin Antagonists Phase 3
8 Gastrointestinal Agents Phase 3
9 Neurotransmitter Agents Phase 3
10 Histamine Antagonists Phase 3
11 Histamine H1 Antagonists Phase 3
12 Anti-Allergic Agents Phase 3
13 Antipruritics Phase 3
14
Crizotinib Approved Phase 1, Phase 2 877399-52-5 11626560 10366136 10366137 10366138 10366139 10366140 10366141
15 Protein Kinase Inhibitors Phase 1, Phase 2
16
Verteporfin Approved, Investigational Phase 1 129497-78-5
17
Trioxsalen Approved Phase 1 3902-71-4 5585
18
Niacin Approved, Investigational, Nutraceutical Phase 1 59-67-6 938
19
Nicotinamide Approved, Nutraceutical Phase 1 98-92-0 936
20
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1 59-30-3 6037
21 Dihematoporphyrin Ether Phase 1
22 Photosensitizing Agents Phase 1
23 Nicotinic Acids Phase 1
24 Trace Elements Phase 1
25 Vitamin B Complex Phase 1
26 Vitamins Phase 1
27 Micronutrients Phase 1
28 Folate Nutraceutical Phase 1
29 Vitamin B3 Nutraceutical Phase 1
30 Vitamin B9 Nutraceutical Phase 1
31
Dopamine Approved 51-61-6, 62-31-7 681
32 Fluorides
33 Dihydroxyphenylalanine
34 Dopamine Agents

Interventional clinical trials:


id Name Status NCT ID Phase
1 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3
2 Crizotinib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Anaplastic Large Cell Lymphoma Active, not recruiting NCT00939770 Phase 1, Phase 2
3 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors Unknown status NCT00002647 Phase 1
4 Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma Completed NCT01273090 Phase 1
5 18F-FDOPA PET/CT or PET/MRI in Measuring Tumors in Patients With Newly-Diagnosed or Recurrent Gliomas Terminated NCT02175745
6 Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors Withdrawn NCT02194452

Search NIH Clinical Center for Gemistocytic Astrocytoma

Genetic Tests for Gemistocytic Astrocytoma

Anatomical Context for Gemistocytic Astrocytoma

MalaCards organs/tissues related to Gemistocytic Astrocytoma:

39
Brain, Thyroid, Spinal Cord

Publications for Gemistocytic Astrocytoma

Articles related to Gemistocytic Astrocytoma:

(show all 16)
id Title Authors Year
1
Magnetic resonance imaging features of gemistocytic astrocytoma. ( 27766769 )
2016
2
Alterations of the RRAS and ERCC1 genes at 19q13 in gemistocytic astrocytomas. ( 25192052 )
2014
3
Perfusion MR imaging and MR spectroscopy of gemistocytic astrocytoma. ( 22115534 )
2012
4
Unusual synchronous presentation of maxillary sinus fibrosarcoma and gemistocytic astrocytoma with a complication called leukocytoclastic vasculitis: a case report. ( 19756200 )
2009
5
Immunohistochemical features of a feline spinal cord gemistocytic astrocytoma. ( 18987242 )
2008
6
Cytologic characteristics of subependymal giant cell astrocytoma in squash smears: morphometric comparisons with gemistocytic astrocytoma and giant cell glioblastoma. ( 17536538 )
2007
7
Congenital gemistocytic astrocytoma in a fetus. ( 15864706 )
2006
8
Gemistocytic astrocytomas: histomorphology, proliferative potential and genetic alterations--a study of 32 cases. ( 16614946 )
2006
9
November 2003: neonatal female with congenital brain tumor. Congenital gemistocytic astrocytoma. ( 15193038 )
2004
10
Genotype-phenotype correlation in gemistocytic astrocytomas. ( 11152345 )
2001
11
p53 and PTEN gene mutations in gemistocytic astrocytomas. ( 9650746 )
1998
12
Gemistocytic astrocytoma in a one-month-old llama. ( 2365629 )
1990
13
Multiple primary malignant tumours: gemistocytic astrocytoma with leptomeningeal spreading and papillary thyroid carcinoma. A case report. ( 2251958 )
1990
14
A gemistocytic astrocytoma demonstrated high intensity on MR images. Protein hydration layer. ( 2398944 )
1990
15
Development of Hodgkin's disease in a patient receiving procarbazine, CCNU, and vincristine therapy for a gemistocytic astrocytoma. ( 626997 )
1978
16
Gemistocytic astrocytoma: cytological observations on the rate of hydrolysis of some phosphoric acid esters. ( 13301910 )
1955

Variations for Gemistocytic Astrocytoma

Expression for Gemistocytic Astrocytoma

Search GEO for disease gene expression data for Gemistocytic Astrocytoma.

Pathways for Gemistocytic Astrocytoma

Pathways related to Gemistocytic Astrocytoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
10.99 GFAP S100B
2 10.53 GFAP S100B

GO Terms for Gemistocytic Astrocytoma

Biological processes related to Gemistocytic Astrocytoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 central nervous system development GO:0007417 9.32 PTEN S100B
2 cellular response to hypoxia GO:0071456 9.26 PTEN S100B
3 memory GO:0007613 9.16 PTEN S100B
4 learning or memory GO:0007611 8.96 PTEN S100B
5 long-term synaptic potentiation GO:0060291 8.62 PTEN S100B

Molecular functions related to Gemistocytic Astrocytoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 8.8 GFAP PTEN S100B

Sources for Gemistocytic Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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