MCID: GMS001
MIFTS: 37

Gemistocytic Astrocytoma malady

Neuronal, Cancer categories

Summaries for Gemistocytic Astrocytoma

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33MalaCards
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MalaCards: Gemistocytic Astrocytoma, also known as gemistocytic astrocytic tumor, is related to astrocytoma and subependymal giant cell astrocytoma. An important gene associated with Gemistocytic Astrocytoma is S100B (S100 calcium binding protein B), and among its related pathways are Glioma and TP53 network. The compounds eosin and s 100 have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and thyroid, and related mouse phenotypes are muscle and pigmentation.

Aliases & Classifications for Gemistocytic Astrocytoma

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 35MeSH, 40NCIt, 57SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Neuronal


Aliases & Descriptions:

gemistocytic astrocytoma 8 10 45 49 61
gemistocytic astrocytic tumor 8


External Ids:

Disease Ontology8 DOID:7005
MeSH35 D001254
SNOMED-CT57 73982001
NCIt40 C4321

Related Diseases for Gemistocytic Astrocytoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Gemistocytic Astrocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 102)
idRelated DiseaseScoreTop Affiliating Genes
1astrocytoma31.1S100B, EGFR, GFAP, PTEN, TP53
2subependymal giant cell astrocytoma30.3GFAP
3giant cell glioblastoma30.3EGFR, GFAP, PTEN
4diffuse astrocytoma10.4
5papillary carcinoma10.2
6spinal cord astrocytoma10.2
7vasculitis10.2
8gastrointestinal stromal tumor10.0S100B
9leiomyoma10.0S100B
10granular cell tumor10.0S100B
11ganglioneuroblastoma10.0S100B
12teratoma10.0GFAP
13smooth muscle tumor10.0S100B
14chondrosarcoma10.0S100B
15neurofibroma10.0S100B
16prion disease10.0GFAP
17peutz-jeghers syndrome10.0PTEN
18ischemia10.0GFAP
19amyotrophic lateral sclerosis10.0GFAP
20pineoblastoma10.0GFAP
21turcot syndrome10.0PTEN
22papilloma10.0TP53
23endometriosis10.0PTEN
24gallbladder cancer10.0TP53
25dementia10.0GFAP
26skin cancer10.0TP53
27neuroblastoma10.0TP53
28osteosarcoma10.0TP53
29nephroblastoma10.0TP53
30adrenocortical carcinoma10.0TP53
31xeroderma pigmentosum10.0TP53
32liposarcoma10.0TP53
33azoospermia10.0SYCP3
34paraganglioma10.0GFAP, S100B
35hemangioblastoma10.0S100B, GFAP
36chordoma10.0GFAP, S100B
37myoepithelioma10.0GFAP, S100B
38myxopapillary ependymoma10.0S100B, GFAP
39familial adenomatous polyposis10.0TP53
40ganglioglioma10.0GFAP, S100B
41papillary ependymoma10.0GFAP, S100B
42gliosarcoma10.0PTEN, GFAP
43choroid plexus carcinoma10.0GFAP, S100B
44gliomatosis cerebri10.0PTEN, GFAP
45choroid plexus papilloma10.0S100B, GFAP
46pineocytoma10.0S100B, GFAP
47benign mesothelioma10.0TP53
48alzheimer's disease10.0GFAP, S100B
49nasopharynx carcinoma10.0TP53
50dermatofibrosarcoma protuberans10.0S100B

Graphical network of the top 20 diseases related to Gemistocytic Astrocytoma:



Diseases related to gemistocytic astrocytoma

Clinical Features for Gemistocytic Astrocytoma

Drugs & Therapeutics for Gemistocytic Astrocytoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Gemistocytic Astrocytoma

Drug clinical trials:

Search ClinicalTrials for Gemistocytic Astrocytoma

Search NIH Clinical Center for Gemistocytic Astrocytoma

Search CenterWatch for Gemistocytic Astrocytoma

Genetic Tests for Gemistocytic Astrocytoma

Anatomical Context for Gemistocytic Astrocytoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Gemistocytic Astrocytoma:

33
Brain, Spinal cord, Thyroid

Animal Models for Gemistocytic Astrocytoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Gemistocytic Astrocytoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053699.6TP53, GFAP
2MP:00011868.7TP53, BCL2, PTEN, EGFR
3MP:00028738.3TP53, PTEN, GFAP, EGFR, S100B
4MP:00053818.3EGFR, GFAP, PTEN, BCL2, TP53
5MP:00053918.2EGFR, GFAP, PTEN, BCL2, TP53
6MP:00053798.0TP53, BCL2, PTEN, SYCP3, EGFR
7MP:00107717.9S100B, EGFR, PTEN, BCL2, TP53

Publications for Gemistocytic Astrocytoma

Sources:
51PubMed
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Articles related to Gemistocytic Astrocytoma:

(show all 14)
idTitleAuthorsYear
1
Perfusion MR imaging and MR spectroscopy of gemistocytic astrocytoma. (22115534)
2012
2
Unusual synchronous presentation of maxillary sinus fibrosarcoma and gemistocytic astrocytoma with a complication called leukocytoclastic vasculitis: a case report. (19756200)
2009
3
Immunohistochemical features of a feline spinal cord gemistocytic astrocytoma. (18987242)
2008
4
Cytologic characteristics of subependymal giant cell astrocytoma in squash smears: morphometric comparisons with gemistocytic astrocytoma and giant cell glioblastoma. (17536538)
2007
5
Congenital gemistocytic astrocytoma in a fetus. (15864706)
2006
6
Gemistocytic astrocytomas: histomorphology, proliferative potential and genetic alterations--a study of 32 cases. (16614946)
2006
7
November 2003: neonatal female with congenital brain tumor. Congenital gemistocytic astrocytoma. (15193038)
2004
8
Genotype-phenotype correlation in gemistocytic astrocytomas. (11152345)
2001
9
p53 and PTEN gene mutations in gemistocytic astrocytomas. (9650746)
1998
10
Multiple primary malignant tumours: gemistocytic astrocytoma with leptomeningeal spreading and papillary thyroid carcinoma. A case report. (2251958)
1990
11
Gemistocytic astrocytoma in a one-month-old llama. (2365629)
1990
12
A gemistocytic astrocytoma demonstrated high intensity on MR images. Protein hydration layer. (2398944)
1990
13
Development of Hodgkin's disease in a patient receiving procarbazine, CCNU, and vincristine therapy for a gemistocytic astrocytoma. (626997)
1978
14
Gemistocytic astrocytoma: cytological observations on the rate of hydrolysis of some phosphoric acid esters. (13301910)
1955

Genetic Variations for Gemistocytic Astrocytoma

Expression for genes affiliated with Gemistocytic Astrocytoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gemistocytic Astrocytoma

Search GEO for disease gene expression data for Gemistocytic Astrocytoma.

Pathways for genes affiliated with Gemistocytic Astrocytoma

Sources:
30KEGG, 38NCBI BioSystems Database, 52QIAGEN, 54Reactome, 53R&D Systems, 60Tocris Bioscience, 12EMD Millipore
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Pathways related to Gemistocytic Astrocytoma according to GeneCards/GeneDecks:

(show all 27)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.9TP53
29.4TP53, BCL2
3
Hide members
9.4TP53, BCL2
4
Hide members
9.4TP53, BCL2
5
Hide members
9.4TP53, BCL2
69.3TP53, EGFR
7
Hide members
9.0TP53, BCL2, PTEN
89.0PTEN, BCL2, TP53
9
Hide members
9.0PTEN, BCL2, TP53
109.0PTEN, BCL2, TP53
11
Hide members
9.0PTEN, BCL2, TP53
129.0EGFR, GFAP, TP53
139.0EGFR, PTEN, TP53
149.0TP53, PTEN, EGFR
15
Hide members
8.9S100B, EGFR, GFAP, PTEN
16
Hide members
8.9TP53, BCL2, EGFR
178.5EGFR, PTEN, BCL2, TP53
188.5EGFR, PTEN, BCL2, TP53
198.5EGFR, PTEN, BCL2, TP53
20
Hide members
8.5EGFR, PTEN, BCL2, TP53
21
Hide members
8.5EGFR, PTEN, BCL2, TP53
228.5EGFR, PTEN, BCL2, TP53
238.5TP53, BCL2, PTEN, EGFR
248.5TP53, BCL2, PTEN, EGFR
25
Hide members
8.5TP53, BCL2, PTEN, EGFR
26
Hide members
8.5TP53, BCL2, PTEN, EGFR
27
Hide members
8.2EGFR, GFAP, PTEN, BCL2, TP53

Compounds for genes affiliated with Gemistocytic Astrocytoma

Sources:
45Novoseek, 50PharmGKB, 60Tocris Bioscience, 11DrugBank, 24HMDB, 29IUPHAR, 2BitterDB
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Compounds related to Gemistocytic Astrocytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 68)
idCompoundScoreTop Affiliating Genes
1eosin4510.1GFAP, S100B
2s 1004510.1S100B, GFAP
3etoposide45 50 60 1113.1S100B, BCL2
42,3-cyclic nucleotide4510.0S100B, GFAP
5panitumumab45 50 1111.9PTEN, EGFR
6reticulin459.9GFAP, S100B
7ly294002459.8BCL2, EGFR
8hematoxylin459.8PTEN, GFAP, S100B
9tanshinone iia459.8BCL2, TP53
103-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide459.7S100B, PTEN, BCL2
1110-hydroxycamptothecin459.7TP53, BCL2
127-hydroxystaurosporine45 1110.6BCL2, TP53
13shikonin459.6BCL2, EGFR
14dutp459.5GFAP, BCL2, TP53
15quercetin45 60 11 2412.4GFAP, PTEN, BCL2
16noxa459.4PTEN, BCL2, TP53
17indole-3-carbinol459.4PTEN, BCL2, TP53
18bcnu459.4EGFR, GFAP, TP53
19cytarabine45 50 1111.3TP53, BCL2, GFAP
20topotecan45 1110.3EGFR, BCL2, TP53
21suberoylanilide hydroxamic acid459.3TP53, BCL2, EGFR
22flavopiridol45 1110.3EGFR, BCL2, TP53
23imatinib45 50 1111.2BCL2, PTEN, EGFR, S100B
24carboplatin45 50 1111.2EGFR, BCL2, TP53
25cyclophosphamide45 50 1111.2PTEN, BCL2, TP53
26adpribose459.2EGFR, BCL2, TP53
27thymidylate459.1EGFR, BCL2, TP53
28pd 98,059459.1EGFR, GFAP, PTEN, BCL2
29docetaxel45 50 60 1112.1TP53, BCL2, EGFR
30chlorambucil45 1110.1BCL2, TP53
31genistein45 29 60 2 11 2414.1BCL2, PTEN, GFAP, EGFR
32taxane459.0EGFR, PTEN, BCL2, TP53
33bortezomib45 119.9TP53, BCL2, PTEN, EGFR
34gemcitabine45 50 1110.9EGFR, PTEN, BCL2, TP53
35mg 13245 609.9EGFR, PTEN, BCL2, TP53
36arsenite45 249.9TP53, BCL2, PTEN
37testosterone45 60 11 2411.9PTEN, GFAP, EGFR, S100B
385fluorouracil458.9TP53, BCL2, PTEN, EGFR
39tamoxifen45 50 29 1111.9TP53, BCL2, PTEN, EGFR
40curcumin458.9EGFR, BCL2, TP53
41doxorubicin45 50 1110.8TP53, BCL2, PTEN, EGFR
42cisplatin45 50 60 1111.6EGFR, GFAP, PTEN, BCL2, TP53
43cycloheximide458.6TP53, BCL2, PTEN, GFAP, EGFR
44paclitaxel45 50 1110.3TP53, BCL2, PTEN, GFAP, EGFR, S100B
45paraffin458.3S100B, EGFR, GFAP, PTEN, BCL2, TP53
46progesterone45 60 29 11 2412.3S100B, EGFR, GFAP, PTEN, BCL2, TP53
47vegf458.3S100B, EGFR, GFAP, PTEN, BCL2, TP53
48estrogen458.3S100B, EGFR, GFAP, PTEN, BCL2, TP53
49retinoic acid45 249.3S100B, EGFR, GFAP, PTEN, BCL2, TP53
50serine458.2S100B, EGFR, GFAP, PTEN, BCL2, TP53

GO Terms for genes affiliated with Gemistocytic Astrocytoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Gemistocytic Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear membraneGO:0319659.0BCL2, TSGA10, EGFR
2cytoplasmGO:0057376.2TP53, S100B, MRI1, EGFR, GFAP, PTEN

Biological processes related to Gemistocytic Astrocytoma according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1learning or memoryGO:0076119.8PTEN, S100B
2long-term synaptic potentiationGO:0602919.7PTEN, GFAP, S100B
3digestive tract morphogenesisGO:0485469.7BCL2, EGFR
4B cell lineage commitmentGO:0023269.7TP53, BCL2
5regulation of mitochondrial membrane permeabilityGO:0469029.7TP53, BCL2
6regulation of protein stabilityGO:0316479.6BCL2, PTEN
7release of cytochrome c from mitochondriaGO:0018369.6TP53, BCL2
8cell agingGO:0075699.5TP53, BCL2
9positive regulation of intrinsic apoptotic signaling pathwayGO:20012449.5TP53, BCL2
10response to gamma radiationGO:0103329.5BCL2, TP53
11central nervous system developmentGO:0074179.4S100B, PTEN, TP53
12T cell differentiation in thymusGO:0330779.3TP53, BCL2
13neuron apoptotic processGO:0514029.1TP53, BCL2
14innate immune responseGO:0450879.0S100B, EGFR, PTEN, BCL2
15cell proliferationGO:0082838.9S100B, EGFR, PTEN, TP53
16negative regulation of apoptotic processGO:0430668.7EGFR, PTEN, BCL2, TP53

Molecular functions related to Gemistocytic Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein phosphatase 2A bindingGO:0517219.1BCL2, TP53
2enzyme bindingGO:0198999.0TP53, PTEN, EGFR
3identical protein bindingGO:0428027.6TP53, BCL2, EGFR, MRI1, S100B

Products for genes affiliated with Gemistocytic Astrocytoma

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Sources for Gemistocytic Astrocytoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet