MCID: GMS001
MIFTS: 35

Gemistocytic Astrocytoma

Categories: Neuronal diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Gemistocytic Astrocytoma

MalaCards integrated aliases for Gemistocytic Astrocytoma:

Name: Gemistocytic Astrocytoma 12 55 51 14 69
Gemistocytic Astrocytic Tumor 12

Classifications:

Orphanet: 55  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:7005
MeSH 41 D001254
NCIt 46 C4321
SNOMED-CT 64 73982001
Orphanet 55 ORPHA251604
UMLS via Orphanet 70 C0334581
ICD10 via Orphanet 33 C71.9
UMLS 69 C0334581

Summaries for Gemistocytic Astrocytoma

MalaCards based summary : Gemistocytic Astrocytoma, also known as gemistocytic astrocytic tumor, is related to fibrillary astrocytoma and astrocytoma, and has symptoms including sensory manifestations, motor manifestations and seizures. An important gene associated with Gemistocytic Astrocytoma is IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2, Mitochondrial), and among its related pathways/superpathways are Signaling by ERBB4 and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Cyproheptadine and Histamine have been mentioned in the context of this disorder. Affiliated tissues include brain, thyroid and spinal cord, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Gemistocytic Astrocytoma

Diseases related to Gemistocytic Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 fibrillary astrocytoma 32.2 GFAP IDH2
2 astrocytoma 30.0 GFAP PTEN S100B
3 subependymal giant cell astrocytoma 29.9 GFAP S100B
4 giant cell glioblastoma 29.6 GFAP PTEN
5 oligodendroglioma 29.3 GFAP IDH2 PTEN
6 oligoastrocytoma 10.2 GFAP IDH2
7 protoplasmic astrocytoma 10.2 GFAP IDH2
8 intracranial cysts 10.1 GFAP S100B
9 chordoid meningioma 10.1 GFAP S100B
10 syringocystadenoma papilliferum 10.0 GFAP S100B
11 dysembryoplastic neuroepithelial tumor 10.0 GFAP S100B
12 chordoid glioma 10.0 GFAP S100B
13 myxopapillary ependymoma 10.0 GFAP S100B
14 syringoma 10.0 GFAP S100B
15 angiocentric glioma 10.0 GFAP S100B
16 pineocytoma 10.0 GFAP S100B
17 papillary ependymoma 10.0 GFAP S100B
18 perineurioma 10.0 GFAP S100B
19 papilloma of choroid plexus 10.0 GFAP S100B
20 granular cell tumor 10.0 GFAP S100B
21 traumatic brain injury 10.0 GFAP S100B
22 pancreatic gastrinoma 10.0 GFAP S100B
23 optic nerve glioma 10.0 GFAP S100B
24 ganglioglioma 10.0 GFAP S100B
25 ependymoma 10.0 GFAP S100B
26 myoepithelioma 10.0 GFAP S100B
27 brain injury 10.0 GFAP S100B
28 thyroid cancer, nonmedullary, 1 10.0
29 fibrosarcoma 10.0
30 thyroiditis 10.0
31 vasculitis 10.0
32 glioblastoma 10.0
33 chordoma 10.0 GFAP S100B
34 neurilemmoma 9.9 GFAP S100B
35 adult astrocytic tumour 9.9 IDH2 PTEN
36 neuroma 9.9 GFAP S100B
37 gangliocytoma 9.9 GFAP PTEN
38 hemangioblastoma 9.9 GFAP S100B
39 neuronal ceroid-lipofuscinoses 9.9 GFAP S100B
40 pleomorphic adenoma 9.9 GFAP S100B
41 gliomatosis cerebri 9.9 GFAP PTEN
42 hydromyelia 9.8 PTEN S100B
43 mixed type thymoma 9.8 PTEN S100B
44 tuberous sclerosis 9.8 GFAP S100B
45 histiocytic sarcoma 9.8 PTEN S100B
46 megalencephaly 9.7 PTEN S100B
47 pilocytic astrocytoma 9.7 GFAP PTEN
48 glioma 9.6 IDH2 PTEN
49 grade iii astrocytoma 9.6 GFAP IDH2 PTEN
50 brain cancer 9.6 GFAP IDH2 PTEN

Graphical network of the top 20 diseases related to Gemistocytic Astrocytoma:



Diseases related to Gemistocytic Astrocytoma

Symptoms & Phenotypes for Gemistocytic Astrocytoma

UMLS symptoms related to Gemistocytic Astrocytoma:


sensory manifestations, motor manifestations, seizures, headache

GenomeRNAi Phenotypes related to Gemistocytic Astrocytoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.17 S100B
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.17 S100B
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.17 S100B
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.17 S100B
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 9.17 PTEN S100B
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.17 PTEN

Drugs & Therapeutics for Gemistocytic Astrocytoma

Drugs for Gemistocytic Astrocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyproheptadine Approved Phase 3 129-03-3 2913
2
Histamine Approved, Investigational Phase 3 51-45-6, 75614-87-8 774
3 Dermatologic Agents Phase 3,Phase 1
4 Anti-Allergic Agents Phase 3
5 Antipruritics Phase 3
6 Gastrointestinal Agents Phase 3
7 Histamine Antagonists Phase 3
8 Histamine H1 Antagonists Phase 3
9
Histamine Phosphate Phase 3 51-74-1 65513
10 Neurotransmitter Agents Phase 3
11
Serotonin Phase 3 50-67-9 5202
12 Serotonin Agents Phase 3
13 Serotonin Antagonists Phase 3
14
Crizotinib Approved Phase 1, Phase 2 877399-52-5 11626560 10366136 10366137 10366138 10366139 10366140 10366141
15 Protein Kinase Inhibitors Phase 1, Phase 2
16
Trioxsalen Approved Phase 1 3902-71-4 5585
17
Verteporfin Approved, Investigational Phase 1 129497-78-5
18 Dihematoporphyrin Ether Phase 1
19 Photosensitizing Agents Phase 1
20
Dopamine Approved 51-61-6, 62-31-7 681
21 Dihydroxyphenylalanine
22 Dopamine Agents
23 Fluorides

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
2 Crizotinib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Anaplastic Large Cell Lymphoma Active, not recruiting NCT00939770 Phase 1, Phase 2 crizotinib
3 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors Unknown status NCT00002647 Phase 1 verteporfin
4 Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma Completed NCT01273090 Phase 1 imetelstat sodium
5 18F-FDOPA PET/CT or PET/MRI in Measuring Tumors in Patients With Newly-Diagnosed or Recurrent Gliomas Terminated NCT02175745 18F-fluoro-dihydroxyphenylalanine
6 Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors Withdrawn NCT02194452

Search NIH Clinical Center for Gemistocytic Astrocytoma

Genetic Tests for Gemistocytic Astrocytoma

Anatomical Context for Gemistocytic Astrocytoma

MalaCards organs/tissues related to Gemistocytic Astrocytoma:

38
Brain, Thyroid, Spinal Cord

Publications for Gemistocytic Astrocytoma

Articles related to Gemistocytic Astrocytoma:

(show all 17)
# Title Authors Year
1
Synchronous gemistocytic astrocytoma IDH-mutant and oligodendroglioma IDH-mutant and 1p/19q-codeleted in a patient with CCDC26 polymorphism. ( 28550371 )
2017
2
Magnetic resonance imaging features of gemistocytic astrocytoma. ( 27766769 )
2016
3
Alterations of the RRAS and ERCC1 genes at 19q13 in gemistocytic astrocytomas. ( 25192052 )
2014
4
Perfusion MR imaging and MR spectroscopy of gemistocytic astrocytoma. ( 22115534 )
2012
5
Unusual synchronous presentation of maxillary sinus fibrosarcoma and gemistocytic astrocytoma with a complication called leukocytoclastic vasculitis: a case report. ( 19756200 )
2009
6
Immunohistochemical features of a feline spinal cord gemistocytic astrocytoma. ( 18987242 )
2008
7
Cytologic characteristics of subependymal giant cell astrocytoma in squash smears: morphometric comparisons with gemistocytic astrocytoma and giant cell glioblastoma. ( 17536538 )
2007
8
Congenital gemistocytic astrocytoma in a fetus. ( 15864706 )
2006
9
Gemistocytic astrocytomas: histomorphology, proliferative potential and genetic alterations--a study of 32 cases. ( 16614946 )
2006
10
November 2003: neonatal female with congenital brain tumor. Congenital gemistocytic astrocytoma. ( 15193038 )
2004
11
Genotype-phenotype correlation in gemistocytic astrocytomas. ( 11152345 )
2001
12
p53 and PTEN gene mutations in gemistocytic astrocytomas. ( 9650746 )
1998
13
Multiple primary malignant tumours: gemistocytic astrocytoma with leptomeningeal spreading and papillary thyroid carcinoma. A case report. ( 2251958 )
1990
14
Gemistocytic astrocytoma in a one-month-old llama. ( 2365629 )
1990
15
A gemistocytic astrocytoma demonstrated high intensity on MR images. Protein hydration layer. ( 2398944 )
1990
16
Development of Hodgkin's disease in a patient receiving procarbazine, CCNU, and vincristine therapy for a gemistocytic astrocytoma. ( 626997 )
1978
17
Gemistocytic astrocytoma: cytological observations on the rate of hydrolysis of some phosphoric acid esters. ( 13301910 )
1955

Variations for Gemistocytic Astrocytoma

Expression for Gemistocytic Astrocytoma

Search GEO for disease gene expression data for Gemistocytic Astrocytoma.

Pathways for Gemistocytic Astrocytoma

Pathways related to Gemistocytic Astrocytoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.99 GFAP S100B
2 10.52 GFAP S100B

GO Terms for Gemistocytic Astrocytoma

Biological processes related to Gemistocytic Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 central nervous system development GO:0007417 9.32 PTEN S100B
2 cellular response to hypoxia GO:0071456 9.26 PTEN S100B
3 memory GO:0007613 9.16 PTEN S100B
4 learning or memory GO:0007611 8.96 PTEN S100B
5 long-term synaptic potentiation GO:0060291 8.8 GFAP PTEN S100B

Sources for Gemistocytic Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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