MCID: GMS001
MIFTS: 37

Gemistocytic Astrocytoma malady

Neuronal diseases, Cancer diseases, Rare diseases categories

Aliases & Classifications for Gemistocytic Astrocytoma

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 61UMLS, 56SNOMED-CT, 33MeSH, 39NCIt, 62UMLS via Orphanet
See all sources

Aliases & Descriptions for Gemistocytic Astrocytoma:

Name: Gemistocytic Astrocytoma 8 10 44 48 61
 
Gemistocytic Astrocytic Tumor 8


Classifications:



External Ids:

Disease Ontology8 DOID:7005
MeSH33 D001254
NCIt39 C4321
SNOMED-CT56 73982001
Orphanet48 251604
UMLS via Orphanet62 C0334581

Summaries for Gemistocytic Astrocytoma

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MalaCards based summary: Gemistocytic Astrocytoma, also known as gemistocytic astrocytic tumor, is related to subependymal giant cell astrocytoma and astrocytoma. An important gene associated with Gemistocytic Astrocytoma is IDH2 (isocitrate dehydrogenase 2 (NADP+), mitochondrial), and among its related pathways are Nuclear signaling by ERBB4 and Gastric cancer network 2. The compounds eosin and s 100 have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and thyroid, and related mouse phenotypes are pigmentation and digestive/alimentary.

Related Diseases for Gemistocytic Astrocytoma

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Diseases related to Gemistocytic Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 58)
idRelated DiseaseScoreTop Affiliating Genes
1subependymal giant cell astrocytoma31.1GFAP
2astrocytoma30.5GFAP, PTEN, TP53, S100B, EGFR
3giant cell glioblastoma30.4GFAP, PTEN, EGFR
4glioblastoma29.3IDH2, GFAP, PTEN, TP53, S100B, EGFR
5pineoblastoma10.5GFAP
6mismatch repair cancer syndrome10.5PTEN
7fibrillary astrocytoma10.4
8myxopapillary ependymoma10.3S100B, GFAP
9papillary ependymoma10.3S100B, GFAP
10choroid plexus carcinoma10.3GFAP, S100B
11gliosarcoma10.3PTEN, GFAP
12choroid plexus papilloma10.3S100B, GFAP
13syringoma10.3GFAP, S100B
14pineocytoma10.3GFAP, S100B
15gliomatosis cerebri10.3PTEN, GFAP
16myoepithelioma10.3GFAP, S100B
17hemangioblastoma10.3GFAP, S100B
18ganglioglioma10.3GFAP, S100B
19chordoma10.3GFAP, S100B
20pleomorphic adenoma10.3S100B, GFAP
21fibrosarcoma10.2
22thyroiditis10.2
23vasculitis10.2
24neurilemmoma10.2S100B, GFAP
25malignant peripheral nerve sheath tumor10.2EGFR, S100B
26anaplastic ependymoma10.2S100B, PTEN, GFAP
27meningioma, familial10.2S100B, PTEN, GFAP
28ganglioneuroma10.2GFAP, PTEN, S100B
29pilocytic astrocytoma10.2S100B, PTEN, GFAP
30tuberous sclerosis10.1S100B, PTEN, GFAP
31malignant mixed mullerian tumor10.1TP53, S100B
32paraganglioma10.1S100B, GFAP, IDH2
33li-fraumeni syndrome10.1PTEN, TP53
34ependymoma10.1EGFR, S100B, GFAP
35oligodendroglioma10.0EGFR, PTEN, GFAP
36endometrial cancer10.0PTEN, TP53
37anaplastic oligodendroglioma10.0GFAP, PTEN, EGFR
38thyroid cancer, anaplastic10.0TP53, PTEN
39leiomyosarcoma10.0TP53, S100B
40ductal carcinoma in situ10.0EGFR, TP53
41papilloma10.0TP53
42breast ductal carcinoma10.0TP53, EGFR
43medulloblastoma10.0S100B, TP53, GFAP
44laryngeal carcinoma9.9EGFR, TP53
45bladder cancer, somatic9.9EGFR, TP53
46esophageal cancer9.9TP53, EGFR
47laryngeal squamous cell carcinoma9.8PTEN, TP53, EGFR
48renal cell carcinoma9.8EGFR, TP53
49stomach cancer9.8PTEN, TP53, EGFR
50colorectal cancer9.8PTEN, TP53, EGFR

Graphical network of the top 20 diseases related to Gemistocytic Astrocytoma:



Diseases related to gemistocytic astrocytoma

Symptoms for Gemistocytic Astrocytoma

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Drugs & Therapeutics for Gemistocytic Astrocytoma

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Drug clinical trials:

Search ClinicalTrials for Gemistocytic Astrocytoma

Search NIH Clinical Center for Gemistocytic Astrocytoma

Genetic Tests for Gemistocytic Astrocytoma

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Anatomical Context for Gemistocytic Astrocytoma

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MalaCards organs/tissues related to Gemistocytic Astrocytoma:

31
Brain, Spinal cord, Thyroid

Animal Models for Gemistocytic Astrocytoma or affiliated genes

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MGI Mouse Phenotypes related to Gemistocytic Astrocytoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.6PTEN, TP53, EGFR
2MP:00053818.2EGFR, TP53, PTEN, GFAP
3MP:00053918.1GFAP, PTEN, TP53, EGFR
4MP:00053798.1EGFR, SYCP3, TP53, PTEN
5MP:00028737.9EGFR, S100B, TP53, PTEN, GFAP
6MP:00053697.9GFAP, PTEN, TP53, EGFR

Publications for Gemistocytic Astrocytoma

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Articles related to Gemistocytic Astrocytoma:

(show all 14)
idTitleAuthorsYear
1
Perfusion MR imaging and MR spectroscopy of gemistocytic astrocytoma. (22115534)
2012
2
Unusual synchronous presentation of maxillary sinus fibrosarcoma and gemistocytic astrocytoma with a complication called leukocytoclastic vasculitis: a case report. (19756200)
2009
3
Immunohistochemical features of a feline spinal cord gemistocytic astrocytoma. (18987242)
2008
4
Cytologic characteristics of subependymal giant cell astrocytoma in squash smears: morphometric comparisons with gemistocytic astrocytoma and giant cell glioblastoma. (17536538)
2007
5
Congenital gemistocytic astrocytoma in a fetus. (15864706)
2006
6
Gemistocytic astrocytomas: histomorphology, proliferative potential and genetic alterations--a study of 32 cases. (16614946)
2006
7
November 2003: neonatal female with congenital brain tumor. Congenital gemistocytic astrocytoma. (15193038)
2004
8
Genotype-phenotype correlation in gemistocytic astrocytomas. (11152345)
2001
9
p53 and PTEN gene mutations in gemistocytic astrocytomas. (9650746)
1998
10
Multiple primary malignant tumours: gemistocytic astrocytoma with leptomeningeal spreading and papillary thyroid carcinoma. A case report. (2251958)
1990
11
Gemistocytic astrocytoma in a one-month-old llama. (2365629)
1990
12
A gemistocytic astrocytoma demonstrated high intensity on MR images. Protein hydration layer. (2398944)
1990
13
Development of Hodgkin's disease in a patient receiving procarbazine, CCNU, and vincristine therapy for a gemistocytic astrocytoma. (626997)
1978
14
Gemistocytic astrocytoma: cytological observations on the rate of hydrolysis of some phosphoric acid esters. (13301910)
1955

Variations for Gemistocytic Astrocytoma

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Expression for genes affiliated with Gemistocytic Astrocytoma

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Search GEO for disease gene expression data for Gemistocytic Astrocytoma.

Pathways for genes affiliated with Gemistocytic Astrocytoma

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Pathways related to Gemistocytic Astrocytoma according to GeneCards Suite gene sharing:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7GFAP, S100B
29.0TP53, EGFR
39.0TP53, EGFR
4
Show member pathways
9.0EGFR, TP53
58.6EGFR, TP53, GFAP
6
Show member pathways
8.6EGFR, S100B, PTEN, GFAP
78.6PTEN, TP53, EGFR
88.6TP53, PTEN, EGFR
9
Show member pathways
8.6EGFR, TP53, PTEN
108.6EGFR, TP53, PTEN
118.6TP53, EGFR, PTEN
12
Show member pathways
8.6TP53, EGFR, PTEN
13
Show member pathways
Development EGFR signaling via PIP359
Development PDGF signaling via MAPK cascades59
Apoptosis and survival Anti apoptotic action of membrane bound ESR159
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases59
Development Neurotrophin family signaling59
Apoptosis and survival NGF signaling pathway59
Apoptosis and survival Role of CDK5 in neuronal death and survival59
8.6EGFR, TP53, PTEN
148.6TP53, EGFR, PTEN
158.6PTEN, EGFR, TP53
16
Show member pathways
Signal transduction PTEN pathway59
8.6TP53, EGFR, PTEN
178.6EGFR, PTEN, TP53
188.6PTEN, EGFR, TP53
19
Show member pathways
Signaling Pathways in Glioblastoma36
8.6TP53, EGFR, PTEN
20
Show member pathways
8.2GFAP, PTEN, TP53, EGFR
21
Show member pathways
7.8EGFR, S100B, GFAP, TP53, PTEN

Compounds for genes affiliated with Gemistocytic Astrocytoma

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Compounds related to Gemistocytic Astrocytoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1eosin4410.1S100B, GFAP
2s 1004410.1GFAP, S100B
32,3-cyclic nucleotide4410.1S100B, GFAP
4reticulin4410.1GFAP, S100B
53-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.9PTEN, S100B
6panitumumab44 50 1111.8PTEN, EGFR
7cetuximab44 50 1111.7PTEN, EGFR
8bicalutamide44 60 1111.7PTEN, EGFR
9hematoxylin449.7PTEN, GFAP, S100B
10methionine449.6PTEN, S100B, GFAP
11erlotinib44 50 1111.6PTEN, EGFR
12ethanol44 50 24 1112.6PTEN, GFAP, S100B
13noxa449.5TP53, PTEN
14crcs449.5TP53, PTEN
15glycogen44 2410.5PTEN, S100B, GFAP
16dutp449.4TP53, GFAP
17indole-3-carbinol449.4PTEN, TP53
18imatinib44 50 1111.4EGFR, S100B, PTEN
19temozolomide44 1110.4TP53, EGFR
20trastuzumab44 50 1111.4EGFR, PTEN
21sn 3844 6010.4EGFR, TP53
22agar449.4GFAP, EGFR, PTEN
23pd 98,059449.3PTEN, EGFR, GFAP
24etoposide44 50 60 1112.2S100B, PTEN, TP53
25topotecan44 1110.2EGFR, TP53
26suberoylanilide hydroxamic acid449.1TP53, EGFR
27bcnu449.1GFAP, TP53, EGFR
28genistein44 28 60 1 24 1114.1EGFR, GFAP, PTEN
29oxaliplatin44 50 1111.0TP53, EGFR
30taxane449.0TP53, PTEN, EGFR
31testosterone44 60 24 1112.0S100B, EGFR, GFAP, PTEN
32bortezomib44 50 1111.0PTEN, TP53, EGFR
33gemcitabine44 50 1111.0PTEN, TP53, EGFR
34mg 13244 6010.0TP53, PTEN, EGFR
355fluorouracil449.0PTEN, TP53, EGFR
36flavopiridol44 119.9TP53, EGFR
37tamoxifen44 50 28 1111.9TP53, PTEN, EGFR
38ly294002448.9EGFR, PTEN, TP53
39doxorubicin44 50 1110.8PTEN, EGFR, TP53
40arginine448.8PTEN, GFAP, S100B, TP53
41cisplatin44 50 60 1111.6EGFR, PTEN, GFAP, TP53
42cycloheximide448.6PTEN, GFAP, TP53, EGFR
43thymidine44 249.6GFAP, TP53, S100B
44paclitaxel44 50 1110.2GFAP, TP53, EGFR, S100B, PTEN
45paraffin448.2GFAP, PTEN, TP53, S100B, EGFR
46progesterone44 28 60 24 1112.2PTEN, TP53, S100B, EGFR, GFAP
47vegf448.2TP53, S100B, GFAP, EGFR, PTEN
48estrogen448.2GFAP, EGFR, PTEN, S100B, TP53
49retinoic acid44 249.2EGFR, GFAP, TP53, PTEN, S100B
50serine448.2EGFR, TP53, S100B, PTEN, GFAP

GO Terms for genes affiliated with Gemistocytic Astrocytoma

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Cellular components related to Gemistocytic Astrocytoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00057377.3EGFR, S100B, TSGA10, TP53, PTEN, GFAP

Biological processes related to Gemistocytic Astrocytoma according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1memoryGO:00076139.5S100B, PTEN
2long-term synaptic potentiationGO:00602919.4S100B, PTEN, GFAP
3learning or memoryGO:00076119.2EGFR, S100B, PTEN
4cellular response to drugGO:00356909.0EGFR, TP53
5central nervous system developmentGO:00074178.9S100B, TP53, PTEN
6positive regulation of apoptotic processGO:00430658.9PTEN, TP53, S100B
7positive regulation of cell proliferationGO:00082848.7PTEN, S100B, EGFR
8negative regulation of apoptotic processGO:00430668.6EGFR, TP53, PTEN
9cell proliferationGO:00082838.4PTEN, TP53, S100B, EGFR

Molecular functions related to Gemistocytic Astrocytoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein phosphatase bindingGO:00199038.7EGFR, TP53
2identical protein bindingGO:00428028.7EGFR, S100B, TP53
3enzyme bindingGO:00198998.6EGFR, TP53, PTEN
4protein kinase bindingGO:00199018.5PTEN, TP53, EGFR

Sources for Gemistocytic Astrocytoma

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet