MCID: GMS001
MIFTS: 43

Gemistocytic Astrocytoma malady

Neuronal diseases, Cancer diseases, Rare diseases categories

Summaries for Gemistocytic Astrocytoma

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MalaCards based summary: Gemistocytic Astrocytoma, also known as gemistocytic astrocytic tumor, is related to subependymal giant cell astrocytoma and astrocytoma. An important gene associated with Gemistocytic Astrocytoma is S100B (S100 calcium binding protein B), and among its related pathways are Nuclear signaling by ERBB4 and Androgen receptor signaling pathway. The compounds eosin and s 100 have been mentioned in the context of this disorder. Affiliated tissues include brain and spinal cord, and related mouse phenotypes are pigmentation and digestive/alimentary.

Aliases & Classifications for Gemistocytic Astrocytoma

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Sources:
9Disease Ontology, 11DISEASES, 44Novoseek, 48Orphanet, 61UMLS, 34MeSH, 39NCIt, 56SNOMED-CT, 62UMLS via Orphanet
See all sources

Gemistocytic Astrocytoma, Aliases & Descriptions:

Name: Gemistocytic Astrocytoma 9 11 44 48 61
 
Gemistocytic Astrocytic Tumor 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology9 DOID:7005
MeSH34 D001254
SNOMED-CT56 73982001
NCIt39 C4321
UMLS via Orphanet62 C0334581

Related Diseases for Gemistocytic Astrocytoma

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Diseases related to Gemistocytic Astrocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1subependymal giant cell astrocytoma31.1GFAP
2astrocytoma30.5EGFR, GFAP, S100B, TP53, PTEN
3giant cell glioblastoma30.3GFAP, PTEN, EGFR
4glioblastoma29.7GFAP, EGFR, S100B, PTEN, TP53
5pineoblastoma10.5GFAP
6turcot syndrome10.5PTEN
7fibrillary astrocytoma10.4
8papilloma10.3TP53
9myxopapillary ependymoma10.3S100B, GFAP
10papillary ependymoma10.3S100B, GFAP
11choroid plexus carcinoma10.3GFAP, S100B
12choroid plexus papilloma10.3S100B, GFAP
13pineocytoma10.3S100B, GFAP
14syringoma10.3GFAP, S100B
15myoepithelioma10.3GFAP, S100B
16hemangioblastoma10.3GFAP, S100B
17gliosarcoma10.3PTEN, GFAP
18gliomatosis cerebri10.3GFAP, PTEN
19ganglioglioma10.3S100B, GFAP
20chordoma10.3GFAP, S100B
21pleomorphic adenoma10.3GFAP, S100B
22paraganglioma10.3GFAP, S100B
23neurilemmoma10.3S100B, GFAP
24malignant mixed mullerian tumor10.3S100B, TP53
25fibrosarcoma10.2
26vasculitis10.2
27li-fraumeni syndrome10.2PTEN, TP53
28leiomyosarcoma10.2TP53, S100B
29endometrial carcinoma10.2PTEN, TP53
30thyroid cancer, anaplastic10.2PTEN, TP53
31anaplastic ependymoma10.1S100B, PTEN, GFAP
32meningioma10.1PTEN, S100B, GFAP
33ganglioneuroma10.1S100B, PTEN, GFAP
34pilocytic astrocytoma10.1PTEN, GFAP, S100B
35tuberous sclerosis10.1PTEN, GFAP, S100B
36malignant peripheral nerve sheath tumor10.1S100B, EGFR
37medulloblastoma10.1S100B, TP53, GFAP
38ductal carcinoma in situ10.1EGFR, TP53
39breast ductal carcinoma10.0TP53, EGFR
40ataxia telangiectasia10.0TP53, SYCP3
41thyroid hurthle cell carcinoma10.0TP53, PTEN
42laryngeal benign neoplasm10.0EGFR, TP53
43bladder carcinoma in situ10.0EGFR, TP53
44esophageal cancer10.0TP53, EGFR
45kidney cancer10.0TP53, EGFR
46ependymoma10.0S100B, EGFR, GFAP
47oral cancer10.0EGFR, TP53
48nasopharynx carcinoma9.9EGFR, TP53
49oligodendroglioma9.9GFAP, EGFR, PTEN
50anaplastic oligodendroglioma9.9GFAP, EGFR, PTEN

Graphical network of the top 20 diseases related to Gemistocytic Astrocytoma:



Diseases related to gemistocytic astrocytoma

Symptoms for Gemistocytic Astrocytoma

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Drugs & Therapeutics for Gemistocytic Astrocytoma

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Drug clinical trials:

Search ClinicalTrials for Gemistocytic Astrocytoma

Search NIH Clinical Center for Gemistocytic Astrocytoma

Genetic Tests for Gemistocytic Astrocytoma

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Anatomical Context for Gemistocytic Astrocytoma

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MalaCards organs/tissues related to Gemistocytic Astrocytoma:

32
Brain, Spinal cord

Animal Models for Gemistocytic Astrocytoma or affiliated genes

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MGI Mouse Phenotypes related to Gemistocytic Astrocytoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.7PTEN, TP53, EGFR
2MP:00053818.3GFAP, PTEN, TP53, EGFR
3MP:00053918.2EGFR, TP53, PTEN, GFAP
4MP:00053698.2GFAP, PTEN, TP53, EGFR
5MP:00053898.1EGFR, SYCP3, TP53, PTEN
6MP:00028738.0EGFR, S100B, TP53, PTEN, GFAP
7MP:00053798.0EGFR, SYCP3, TP53, PTEN
8MP:00107717.9PTEN, TP53, S100B, EGFR

Publications for Gemistocytic Astrocytoma

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Articles related to Gemistocytic Astrocytoma:

(show all 13)
idTitleAuthorsYear
1
Perfusion MR imaging and MR spectroscopy of gemistocytic astrocytoma. (22115534)
2012
2
Unusual synchronous presentation of maxillary sinus fibrosarcoma and gemistocytic astrocytoma with a complication called leukocytoclastic vasculitis: a case report. (19756200)
2009
3
Immunohistochemical features of a feline spinal cord gemistocytic astrocytoma. (18987242)
2008
4
Cytologic characteristics of subependymal giant cell astrocytoma in squash smears: morphometric comparisons with gemistocytic astrocytoma and giant cell glioblastoma. (17536538)
2007
5
Congenital gemistocytic astrocytoma in a fetus. (15864706)
2006
6
Gemistocytic astrocytomas: histomorphology, proliferative potential and genetic alterations--a study of 32 cases. (16614946)
2006
7
November 2003: neonatal female with congenital brain tumor. Congenital gemistocytic astrocytoma. (15193038)
2004
8
Genotype-phenotype correlation in gemistocytic astrocytomas. (11152345)
2001
9
p53 and PTEN gene mutations in gemistocytic astrocytomas. (9650746)
1998
10
Gemistocytic astrocytoma in a one-month-old llama. (2365629)
1990
11
A gemistocytic astrocytoma demonstrated high intensity on MR images. Protein hydration layer. (2398944)
1990
12
Development of Hodgkin's disease in a patient receiving procarbazine, CCNU, and vincristine therapy for a gemistocytic astrocytoma. (626997)
1978
13
Gemistocytic astrocytoma: cytological observations on the rate of hydrolysis of some phosphoric acid esters. (13301910)
1955

Variations for Gemistocytic Astrocytoma

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Expression for genes affiliated with Gemistocytic Astrocytoma

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Expression patterns in normal tissues for genes affiliated with Gemistocytic Astrocytoma

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Pathways for genes affiliated with Gemistocytic Astrocytoma

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Pathways related to Gemistocytic Astrocytoma according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7GFAP, S100B
29.4PTEN, EGFR
3
Show member pathways
Translation Non genomic rapid action of Androgen Receptor59
9.4EGFR, PTEN
49.2TP53, PTEN
5
Show member pathways
DNA damage response37
9.2TP53, PTEN
69.0TP53, EGFR
7
Show member pathways
9.0EGFR, TP53
8
Show member pathways
9.0TP53, EGFR
9
Show member pathways
9.0EGFR, TP53
109.0EGFR, TP53
118.6GFAP, TP53, EGFR
12
Show member pathways
8.6EGFR, S100B, PTEN, GFAP
13
Show member pathways
8.6PTEN, TP53, EGFR
148.6PTEN, TP53, EGFR
158.6PTEN, TP53, EGFR
16
Show member pathways
8.6PTEN, TP53, EGFR
178.6PTEN, TP53, EGFR
188.6EGFR, TP53, PTEN
198.6EGFR, TP53, PTEN
20
Show member pathways
Signal transduction PTEN pathway59
8.6EGFR, TP53, PTEN
21
Show member pathways
8.6EGFR, TP53, PTEN
228.6EGFR, TP53, PTEN
238.6EGFR, TP53, PTEN
248.6EGFR, TP53, PTEN
25
Show member pathways
Signaling Pathways in Glioblastoma37
8.6EGFR, TP53, PTEN
26
Show member pathways
Development EGFR signaling via PIP359
Development PDGF signaling via MAPK cascades59
Apoptosis and survival Anti apoptotic action of membrane bound ESR159
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases59
Development Neurotrophin family signaling59
Apoptosis and survival NGF signaling pathway59
Apoptosis and survival Role of CDK5 in neuronal death and survival59
8.6EGFR, TP53, PTEN
27
Show member pathways
8.2GFAP, PTEN, TP53, EGFR
28
Show member pathways
7.8GFAP, PTEN, TP53, S100B, EGFR

Compounds for genes affiliated with Gemistocytic Astrocytoma

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Compounds related to Gemistocytic Astrocytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1eosin4410.1S100B, GFAP
2s 1004410.1S100B, GFAP
32,3-cyclic nucleotide4410.1S100B, GFAP
4reticulin4410.1S100B, GFAP
53-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.8PTEN, S100B
6panitumumab44 50 1211.8PTEN, EGFR
7cetuximab44 50 1211.7EGFR, PTEN
8bicalutamide44 60 1211.7PTEN, EGFR
9hematoxylin449.7PTEN, S100B, GFAP
10methionine449.6GFAP, PTEN, S100B
11ethanol44 50 25 1212.6S100B, GFAP, PTEN
12noxa449.5TP53, PTEN
13erlotinib44 50 1211.5PTEN, EGFR
14glycogen44 2510.5GFAP, S100B, PTEN
15crcs449.5TP53, PTEN
16dutp449.5GFAP, TP53
17indole-3-carbinol449.4TP53, PTEN
18imatinib44 50 1211.4EGFR, S100B, PTEN
19temozolomide44 1210.4TP53, EGFR
20sn 3844 6010.4EGFR, TP53
21agar449.4GFAP, PTEN, EGFR
22pd 98,059449.3GFAP, PTEN, EGFR
23aspartate449.2GFAP, PTEN, S100B
24etoposide44 50 60 1212.2S100B, PTEN, TP53
25topotecan44 1210.2TP53, EGFR
26genistein44 29 60 3 25 1214.2PTEN, EGFR, GFAP
27suberoylanilide hydroxamic acid449.1TP53, EGFR
28bcnu449.1GFAP, TP53, EGFR
29taxane449.0PTEN, TP53, EGFR
30testosterone44 60 25 1212.0PTEN, S100B, GFAP, EGFR
31bortezomib44 50 1211.0PTEN, EGFR, TP53
32gemcitabine44 50 1211.0PTEN, TP53, EGFR
33mg 13244 6010.0TP53, EGFR, PTEN
345fluorouracil449.0PTEN, TP53, EGFR
35leucine448.9S100B, PTEN, GFAP
36oxaliplatin44 50 1210.9EGFR, TP53
37tamoxifen44 50 29 1211.9PTEN, TP53, EGFR
38ly294002448.9PTEN, TP53, EGFR
39thymidine44 259.9TP53, S100B, GFAP
40doxorubicin44 50 1210.8TP53, PTEN, EGFR
41arginine448.8S100B, TP53, PTEN, GFAP
42cisplatin44 50 60 1211.6EGFR, GFAP, PTEN, TP53
43cycloheximide448.6GFAP, PTEN, TP53, EGFR
44paclitaxel44 50 1210.2PTEN, S100B, EGFR, TP53, GFAP
45paraffin448.2EGFR, TP53, PTEN, GFAP, S100B
46progesterone44 29 60 25 1212.2GFAP, EGFR, S100B, TP53, PTEN
47vegf448.2GFAP, PTEN, TP53, S100B, EGFR
48estrogen448.2PTEN, S100B, TP53, EGFR, GFAP
49retinoic acid44 259.2EGFR, GFAP, S100B, TP53, PTEN
50serine448.2EGFR, S100B, TP53, PTEN, GFAP

GO Terms for genes affiliated with Gemistocytic Astrocytoma

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Cellular components related to Gemistocytic Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1PML bodyGO:0166059.2TP53, PTEN
2cytoplasmGO:0057377.0EGFR, S100B, TSGA10, TP53, PTEN, GFAP

Biological processes related to Gemistocytic Astrocytoma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1memoryGO:0076139.7S100B, PTEN
2long-term synaptic potentiationGO:0602919.5S100B, PTEN, GFAP
3learning or memoryGO:0076119.2EGFR, S100B, PTEN
4cellular response to drugGO:0356909.1EGFR, TP53
5positive regulation of cell proliferationGO:0082849.0EGFR, S100B, PTEN
6innate immune responseGO:0450879.0EGFR, S100B, PTEN
7central nervous system developmentGO:0074179.0S100B, TP53, PTEN
8cellular response to hypoxiaGO:0714569.0S100B, TP53
9positive regulation of apoptotic processGO:0430659.0PTEN, TP53, S100B
10negative regulation of apoptotic processGO:0430668.5PTEN, TP53, EGFR
11cell proliferationGO:0082838.4PTEN, TP53, S100B, EGFR

Molecular functions related to Gemistocytic Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integrin bindingGO:0051789.4EGFR, GFAP
2protein phosphatase bindingGO:0199038.9TP53, EGFR
3enzyme bindingGO:0198998.6EGFR, TP53, PTEN
4protein kinase bindingGO:0199018.6EGFR, TP53, PTEN
5identical protein bindingGO:0428028.4EGFR, S100B, TP53

Products for genes affiliated with Gemistocytic Astrocytoma

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Sources for Gemistocytic Astrocytoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet