MCID: GMS001
MIFTS: 33

Gemistocytic Astrocytoma

Categories: Neuronal diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Gemistocytic Astrocytoma

MalaCards integrated aliases for Gemistocytic Astrocytoma:

Name: Gemistocytic Astrocytoma 12 56 52 14 69
Gemistocytic Astrocytic Tumor 12

Classifications:

Orphanet: 56  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:7005
MeSH 42 D001254
NCIt 47 C4321
SNOMED-CT 64 73982001
Orphanet 56 ORPHA251604
UMLS via Orphanet 70 C0334581
ICD10 via Orphanet 34 C71.9
UMLS 69 C0334581

Summaries for Gemistocytic Astrocytoma

MalaCards based summary : Gemistocytic Astrocytoma, also known as gemistocytic astrocytic tumor, is related to giant cell glioblastoma and fibrillary astrocytoma, and has symptoms including headache, seizures and motor manifestations. An important gene associated with Gemistocytic Astrocytoma is IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2, Mitochondrial), and among its related pathways/superpathways are Signaling by ERBB4 and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Cyproheptadine and Histamine have been mentioned in the context of this disorder. Affiliated tissues include brain, thyroid and spinal cord, and related phenotype is Decreased shRNA abundance (Z-score < -2).

Related Diseases for Gemistocytic Astrocytoma

Diseases related to Gemistocytic Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
id Related Disease Score Top Affiliating Genes
1 giant cell glioblastoma 29.1 GFAP PTEN
2 fibrillary astrocytoma 11.0
3 astrocytoma 10.5
4 omphalomesenteric cyst 10.3 GFAP IDH2
5 tendon sheath lipoma 10.3 GFAP IDH2
6 schwannoma of jugular foramen 10.3 GFAP IDH2
7 meningitis and encephalitis 10.2 GFAP S100B
8 spleen angiosarcoma 10.1 GFAP S100B
9 mucinous ovarian cystadenoma 10.1 GFAP S100B
10 reticular pattern testicular yolk sac tumor 10.1 GFAP S100B
11 adenofibroma 10.1 GFAP S100B
12 pleural empyema 10.1 GFAP S100B
13 ganglioglioma 10.1 GFAP S100B
14 papillary glioneuronal tumor 10.1 GFAP S100B
15 vulvar squamous papilloma 10.1 GFAP S100B
16 pituitary dwarfism with large sella turcica 10.1 GFAP S100B
17 pediatric ependymoma 10.1 GFAP S100B
18 prostate disease 10.1 GFAP S100B
19 mixed epithelial stromal tumour 10.1 GFAP S100B
20 skin glomus tumor 10.1 GFAP S100B
21 ulcerative colitis 10.1 GFAP S100B
22 volkmann contracture 10.1 GFAP S100B
23 cervical adenomyoma 10.0 GFAP S100B
24 epidermolysa bullosa simplex with muscular dystrophy 10.0 GFAP S100B
25 brain meningioma 10.0 GFAP S100B
26 sternum cancer 10.0 GFAP S100B
27 early myoclonic encephalopathy 10.0 IDH2 PTEN
28 hypoglossal nerve neoplasm 10.0 GFAP S100B
29 epidermal appendage tumor 9.9 GFAP PTEN
30 connective tissue cancer 9.9 GFAP S100B
31 inflammatory leiomyosarcoma 9.9 GFAP S100B
32 superior vena cava angiosarcoma 9.9 GFAP S100B
33 lymphopenia 9.9 GFAP PTEN
34 oligodendroglioma 9.9
35 fibrosarcoma 9.9
36 subependymal giant cell astrocytoma 9.9
37 thyroiditis 9.9
38 vasculitis 9.9
39 glioblastoma 9.9
40 immune-mediated encephalomyelitis 9.9 PTEN S100B
41 invasive malignant thymoma 9.8 PTEN S100B
42 tetanus neonatorum 9.8 GFAP S100B
43 clear cell ependymoma 9.8 GFAP PTEN
44 juvenile astrocytoma 9.8 GFAP PTEN
45 transitional cell cancer of the renal pelvis and ureter 9.8 PTEN S100B
46 familial idiopathic steroid-resistant nephrotic syndrome with minimal changes 9.7 PTEN S100B
47 diencephalic astrocytomas 9.7 GFAP PTEN
48 myelinoclastic diffuse sclerosis 9.6 PTEN S100B
49 mantle cell lymphoma 9.5 GFAP PTEN
50 cystic lymphangioma 9.5 GFAP IDH2 PTEN

Graphical network of the top 20 diseases related to Gemistocytic Astrocytoma:



Diseases related to Gemistocytic Astrocytoma

Symptoms & Phenotypes for Gemistocytic Astrocytoma

UMLS symptoms related to Gemistocytic Astrocytoma:


headache, seizures, motor manifestations, sensory manifestations

GenomeRNAi Phenotypes related to Gemistocytic Astrocytoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.17 S100B
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.17 S100B
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.17 S100B
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.17 S100B
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 9.17 PTEN S100B
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.17 PTEN

Drugs & Therapeutics for Gemistocytic Astrocytoma

Drugs for Gemistocytic Astrocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyproheptadine Approved Phase 3 129-03-3 2913
2
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
3 Dermatologic Agents Phase 3,Phase 1
4 Anti-Allergic Agents Phase 3
5 Antipruritics Phase 3
6 Gastrointestinal Agents Phase 3
7 Histamine Antagonists Phase 3
8 Histamine H1 Antagonists Phase 3
9
Histamine Phosphate Phase 3 51-74-1 65513
10 Neurotransmitter Agents Phase 3
11
Serotonin Phase 3 50-67-9 5202
12 Serotonin Agents Phase 3
13 Serotonin Antagonists Phase 3
14
Crizotinib Approved Phase 1, Phase 2 877399-52-5 11626560 10366136 10366137 10366138 10366139 10366140 10366141
15 Protein Kinase Inhibitors Phase 1, Phase 2
16
Trioxsalen Approved Phase 1 3902-71-4 5585
17
Verteporfin Approved, Investigational Phase 1 129497-78-5
18
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1 59-30-3 6037
19
Niacin Approved, Investigational, Nutraceutical Phase 1 59-67-6 938
20
Nicotinamide Approved, Nutraceutical Phase 1 98-92-0 936
21 Dihematoporphyrin Ether Phase 1
22 Photosensitizing Agents Phase 1
23 Micronutrients Phase 1
24 Nicotinic Acids Phase 1
25 Trace Elements Phase 1
26 Vitamin B Complex Phase 1
27 Vitamins Phase 1
28 Folate Nutraceutical Phase 1
29 Vitamin B3 Nutraceutical Phase 1
30 Vitamin B9 Nutraceutical Phase 1
31
Dopamine Approved 51-61-6, 62-31-7 681
32 Dihydroxyphenylalanine
33 Dopamine Agents
34 Fluorides

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
2 Crizotinib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Anaplastic Large Cell Lymphoma Active, not recruiting NCT00939770 Phase 1, Phase 2 crizotinib
3 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors Unknown status NCT00002647 Phase 1 verteporfin
4 Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma Completed NCT01273090 Phase 1 imetelstat sodium
5 18F-FDOPA PET/CT or PET/MRI in Measuring Tumors in Patients With Newly-Diagnosed or Recurrent Gliomas Terminated NCT02175745 18F-fluoro-dihydroxyphenylalanine
6 Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors Withdrawn NCT02194452

Search NIH Clinical Center for Gemistocytic Astrocytoma

Genetic Tests for Gemistocytic Astrocytoma

Anatomical Context for Gemistocytic Astrocytoma

MalaCards organs/tissues related to Gemistocytic Astrocytoma:

39
Brain, Thyroid, Spinal Cord

Publications for Gemistocytic Astrocytoma

Articles related to Gemistocytic Astrocytoma:

(show all 17)
id Title Authors Year
1
Synchronous gemistocytic astrocytoma IDH-mutant and oligodendroglioma IDH-mutant and 1p/19q-codeleted in a patient with CCDC26 polymorphism. ( 28550371 )
2017
2
Magnetic resonance imaging features of gemistocytic astrocytoma. ( 27766769 )
2016
3
Alterations of the RRAS and ERCC1 genes at 19q13 in gemistocytic astrocytomas. ( 25192052 )
2014
4
Perfusion MR imaging and MR spectroscopy of gemistocytic astrocytoma. ( 22115534 )
2012
5
Unusual synchronous presentation of maxillary sinus fibrosarcoma and gemistocytic astrocytoma with a complication called leukocytoclastic vasculitis: a case report. ( 19756200 )
2009
6
Immunohistochemical features of a feline spinal cord gemistocytic astrocytoma. ( 18987242 )
2008
7
Cytologic characteristics of subependymal giant cell astrocytoma in squash smears: morphometric comparisons with gemistocytic astrocytoma and giant cell glioblastoma. ( 17536538 )
2007
8
Gemistocytic astrocytomas: histomorphology, proliferative potential and genetic alterations--a study of 32 cases. ( 16614946 )
2006
9
Congenital gemistocytic astrocytoma in a fetus. ( 15864706 )
2006
10
November 2003: neonatal female with congenital brain tumor. Congenital gemistocytic astrocytoma. ( 15193038 )
2004
11
Genotype-phenotype correlation in gemistocytic astrocytomas. ( 11152345 )
2001
12
p53 and PTEN gene mutations in gemistocytic astrocytomas. ( 9650746 )
1998
13
Gemistocytic astrocytoma in a one-month-old llama. ( 2365629 )
1990
14
Multiple primary malignant tumours: gemistocytic astrocytoma with leptomeningeal spreading and papillary thyroid carcinoma. A case report. ( 2251958 )
1990
15
A gemistocytic astrocytoma demonstrated high intensity on MR images. Protein hydration layer. ( 2398944 )
1990
16
Development of Hodgkin's disease in a patient receiving procarbazine, CCNU, and vincristine therapy for a gemistocytic astrocytoma. ( 626997 )
1978
17
Gemistocytic astrocytoma: cytological observations on the rate of hydrolysis of some phosphoric acid esters. ( 13301910 )
1955

Variations for Gemistocytic Astrocytoma

Expression for Gemistocytic Astrocytoma

Search GEO for disease gene expression data for Gemistocytic Astrocytoma.

Pathways for Gemistocytic Astrocytoma

Pathways related to Gemistocytic Astrocytoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
10.99 GFAP S100B
2 10.53 GFAP S100B

GO Terms for Gemistocytic Astrocytoma

Biological processes related to Gemistocytic Astrocytoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 central nervous system development GO:0007417 9.32 PTEN S100B
2 cellular response to hypoxia GO:0071456 9.26 PTEN S100B
3 memory GO:0007613 9.16 PTEN S100B
4 learning or memory GO:0007611 8.96 PTEN S100B
5 long-term synaptic potentiation GO:0060291 8.62 PTEN S100B

Molecular functions related to Gemistocytic Astrocytoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 8.8 GFAP PTEN S100B

Sources for Gemistocytic Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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