MCID: GND002
MIFTS: 51

Gender Identity Disorder malady

Mental diseases category
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Summaries for Gender Identity Disorder

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Disease Ontology:8 A disease of mental health that involves a conflict between a person's actual physical gender and the gender that person identifies himself or herself as.

MalaCards based summary: Gender Identity Disorder, also known as psychosexual identity disorder, is related to transsexualism and androgen insensitivity syndrome. An important gene associated with Gender Identity Disorder is RPGRIP1L (RPGRIP1-like), and among its related pathways are Plasma membrane estrogen receptor signaling and Assembly of RNA Polymerase-II Initiation Complex. The compounds 4-tert-octylphenol and estramustine have been mentioned in the context of this disorder. Affiliated tissues include brain and bone, and related mouse phenotypes are renal/urinary system and adipose tissue.

Wikipedia:65 Gender identity disorder (GID) or gender dysphoria is the formal diagnosis used by psychologists and... more...

Aliases & Classifications for Gender Identity Disorder

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Gender Identity Disorder, Aliases & Descriptions:

Name: Gender Identity Disorder 8 10
 
Psychosexual Identity Disorder 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


External Ids:

Disease Ontology8 DOID:1234
ICD9CM27 302.89, 302.8
SNOMED-CT57 5095008
ICD1025 F64

Related Diseases for Gender Identity Disorder

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Diseases related to Gender Identity Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1transsexualism10.6
2androgen insensitivity syndrome10.4AR
3schizophrenia10.3
4transvestism10.3
5asperger syndrome10.3
6anorexia nervosa10.3
7autism spectrum disorder10.3
8compartment syndrome10.3
9eating disorder10.3
10cerebral meningioma10.3PGR
11germ cell cancer10.2AR, ESR2
12ovarian cyst10.2CYP19A1, ESR2
13partial androgen insensitivity syndrome10.2AR, CYP19A1
14uterine sarcoma10.1ESR1, CYP19A1
15androgenetic alopecia10.1AR, CYP19A1
16prostate disease10.1AR, CYP19A1
17hepatitis10.1
18parkinson's disease10.1
19ego-dystonic sexual orientation10.1
20obsessive-compulsive disorder10.1
21cerebritis10.1
22fetishism10.1
23personality disorder10.1
24substance abuse10.1
25pseudohermaphroditism10.1CYP19A1, AR
26ovarian disease10.1CYP19A1, ESR1
27progesterone resistance10.1ESR1, PGR
28adenosarcoma10.1ESR1, PGR
29abrikosov's tumor10.1CYP19A1, ESR1
30polycystic ovary syndrome10.1CYP19A1, AR
31meningioma10.1ESR1, PGR
32cribriform carcinoma10.1ESR1, PGR
33prolactinoma10.1ESR2, ESR1
34mammary paget's disease10.1PGR, ESR1
35malignant mixed mullerian tumor10.1PGR, ESR1
36cryptorchidism10.1CYP19A1, AR
37bilateral breast cancer10.1ESR1, PGR
38factor vii deficiency10.1ESR1, CYP19A1
39li-fraumeni syndrome10.1PGR, ESR1
40leiomyomatosis10.1ESR1, PGR
41uterine fibroid10.0ESR1, PGR
42pituitary tumors10.0ESR2, ESR1
43inflammatory breast carcinoma10.0ESR1, PGR
44lymphangioleiomyomatosis10.0PGR, ESR1
45klinefelter's syndrome10.0CYP19A1, AR
46angiomyolipoma10.0PGR, ESR1
47estrogen excess10.0PGR, CYP19A1
48breast cancer, invasive ductal10.0PGR, ESR1
49cervical adenocarcinoma10.0PGR, ESR1
50fibromatosis10.0PGR, AR

Graphical network of the top 20 diseases related to Gender Identity Disorder:



Diseases related to gender identity disorder

Symptoms for Gender Identity Disorder

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Drugs & Therapeutics for Gender Identity Disorder

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Drug clinical trials:

Search ClinicalTrials for Gender Identity Disorder

Search NIH Clinical Center for Gender Identity Disorder

Genetic Tests for Gender Identity Disorder

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Anatomical Context for Gender Identity Disorder

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MalaCards organs/tissues related to Gender Identity Disorder:

32
Brain, Bone

Animal Models for Gender Identity Disorder or affiliated genes

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MGI Mouse Phenotypes related to Gender Identity Disorder:

36 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.7AR, RPGRIP1L, ESR1, ESR2
2MP:00053758.6AR, ESR1, ESR2, CYP19A1
3MP:00053718.5PGR, ESR2, ESR1, RPGRIP1L
4MP:00020068.4AR, ESR1, ESR2, PGR
5MP:00053708.3CYP19A1, ESR2, ESR1, RPGRIP1L, AR
6MP:00053808.1PGR, ESR1, RPGRIP1L, AR
7MP:00036318.1CYP19A1, ESR2, ESR1, RPGRIP1L, AR
8MP:00053788.0AR, RPGRIP1L, ESR1, ESR2, CYP19A1
9MP:00053697.8CYP19A1, PGR, ESR2, ESR1, AR
10MP:00053897.8CYP19A1, PGR, ESR2, ESR1, AR
11MP:00028737.8CYP19A1, PGR, ESR2, AR
12MP:00053977.8CYP19A1, PGR, ESR2, ESR1, AR
13MP:00107687.7AR, RPGRIP1L, ESR1, ESR2, PGR
14MP:00053867.7CYP19A1, PGR, ESR2, ESR1, AR
15MP:00053877.7CYP19A1, PGR, ESR2, ESR1, AR
16MP:00053767.5CYP19A1, PGR, ESR2, ESR1, AR
17MP:00053797.5AR, RPGRIP1L, ESR1, ESR2, PGR, CYP19A1
18MP:00053907.5CYP19A1, PGR, ESR2, ESR1, RPGRIP1L, AR
19MP:00107717.5CYP19A1, PGR, ESR2, ESR1, RPGRIP1L, AR
20MP:00053857.4CYP19A1, PGR, ESR2, ESR1, RPGRIP1L, AR
21MP:00053847.4CYP19A1, PGR, ESR2, ESR1, RPGRIP1L, AR

Publications for Gender Identity Disorder

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Articles related to Gender Identity Disorder:

(show top 50)    (show all 165)
idTitleAuthorsYear
1
Differences in personality traits between male-to-female and female-to-male gender identity disorder subjects. (25130781)
2014
2
Testosterone replacement elevates the serum uric acid levels in patients with female to male gender identity disorder. (24047564)
2013
3
Serum concentrations of brain-derived neurotrophic factor in patients with gender identity disorder. (23702250)
2013
4
Gender identity disorder and eating disorders: similarities and differences in terms of body uneasiness. (23347389)
2013
5
Hormone treatment of gender identity disorder in a cohort of children and adolescents. Comment. (22938118)
2012
6
Hormone treatment of gender identity disorder in a cohort of children and adolescents. Comment. (22938117)
2012
7
Report of the American Psychiatric Association Task Force on Treatment of Gender Identity Disorder. (22736225)
2012
8
Social dichotomy versus gender dichotomy: a case report of gender identity disorder. (23162201)
2012
9
Gender identity disorder in twins: a review of the case report literature. (22146048)
2012
10
Editorial Comment to Status of sex reassignment surgery for gender identity disorder in Japan. (22416672)
2012
11
Puberty suppression in gender identity disorder: the Amsterdam experience. (21587245)
2011
12
Where Christ did not go: men, women and Frusculicchi. Gender identity disorder (GID): epistemological and ethical issues relating to the psychiatric diagnosis. (22397088)
2011
13
Dysfunctional core beliefs, perceived parenting behavior and psychopathology in gender identity disorder: A comparison of male-to-female, female-to-male transsexual and nontranssexual control subjects. (21074005)
2011
14
Assessing the utility of diagnostic criteria: a multisite study on gender identity disorder. (20946149)
2011
15
Childhood maltreatment in subjects with male-to-female gender identity disorder. (21833007)
2011
16
Endocrine disruptors, the increase of autism spectrum disorder and its comorbidity with gender identity disorder--a hypothetical association. (21950370)
2011
17
Regional cerebral blood flow changes in female to male gender identity disorder. (20132527)
2010
18
Proposed revisions to gender identity disorder diagnoses in the DSM-5. (20725853)
2010
19
Schizophrenia modifying the expression of gender identity disorder. (18069992)
2009
20
Gender identity disorder in children and adolescents. (19380105)
2009
21
When attachment disorder presents with symptoms of gender identity disorder: case discussion. (19495434)
2009
22
Empathy in boys with gender identity disorder: a comparison to externalizing clinical control boys and community control boys and girls. (17620006)
2008
23
On the "natural history" of gender identity disorder in children. (19034186)
2008
24
What can the Samoan "Fa'afafine" teach us about the Western concept of gender identity disorder in childhood? (17951883)
2007
25
Psychiatric comorbidity among children with gender identity disorder. (17885572)
2007
26
Gender identity disorder and its medico-legal considerations. (17345887)
2007
27
Gender identity disorder. Is this a potentially fatal condition? (18693618)
2007
28
Gender identity disorder. (16892921)
2006
29
Nursing experience of redesigning a schedule to consider gender identity disorder in recruits' physical examination. (17102318)
2006
30
Donor-site morbidity of the radial forearm free flap after 125 phalloplasties in gender identity disorder. (17016186)
2006
31
Clinical and theoretical parallels between desire for limb amputation and gender identity disorder. (16799838)
2006
32
Gender identity disorder: general overview and surgical treatment for vaginoplasty in male-to-female transsexuals. (16267416)
2005
33
Cross-sex hormone treatment does not change sex-sensitive cognitive performance in gender identity disorder patients. (16297984)
2005
34
Adoption in boys with gender identity disorder. (12921464)
2003
35
Demographic characteristics, social competence, and behavior problems in children with gender identity disorder: a cross-national, cross-clinic comparative analysis. (12597698)
2003
36
Gender identity disorder presenting in a girl with Asperger's disorder and obsessive compulsive disorder. (12971211)
2003
37
Psychopathology in the parents of boys with gender identity disorder. (12500069)
2003
38
The heritability of gender identity disorder in a child and adolescent twin sample. (12211624)
2002
39
Gender identity disorder in DSM? (11314563)
2001
40
Gender identity disorder. (10361778)
1999
41
Secondary gender identity disorder - a case report. (21455399)
1999
42
Effects of physical appearance on masculine trait ratings of boys and girls with gender identity disorder. (9604115)
1998
43
Gender identity disorder. (9519623)
1998
44
Gender identity disorder and HIV disease. (8031915)
1994
45
The concept of gender identity disorder in childhood and adolescence after 39 years. (7996589)
1994
46
Intersexuality and the diagnosis of gender identity disorder. (8135650)
1994
47
The psychoanalytic treatment of a preschool boy with a gender identity disorder. (2026849)
1991
48
The association of gender identity disorder with parental separation. (2623124)
1989
49
Gender identity disorder of childhood. Introduction. (4067136)
1985
50
Patterns of intellectual functioning and spatial ability in boys and gender identity disorder. (7066844)
1982

Variations for Gender Identity Disorder

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Expression for genes affiliated with Gender Identity Disorder

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Expression patterns in normal tissues for genes affiliated with Gender Identity Disorder

Search GEO for disease gene expression data for Gender Identity Disorder.

Pathways for genes affiliated with Gender Identity Disorder

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Pathways related to Gender Identity Disorder according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5ESR1, ESR2
2
Show member pathways
9.5ESR1, ESR2
3
Show member pathways
Development Ligand independent activation of ESR1 and ESR260
9.5ESR2, ESR1
49.5ESR1, ESR2
59.5ESR1, ESR2
6
Show member pathways
FOXA transcription factor networks37
9.4ESR1, AR
79.4AR, ESR1
89.3AR, CYP19A1
9
Show member pathways
Cell cycle ESR1 regulation of G1 S transition60
Immune response MIF JAB1 signaling60
Cell cycle Cell cycle generic schema 60
9.1ESR1, PGR
10
Show member pathways
9.1PGR, ESR1
119.0ESR2, ESR1, AR
129.0AR, ESR1, ESR2
13
Show member pathways
8.9ESR2, ESR1, CYP19A1
148.8AR, ESR1, CYP19A1
158.6ESR2, PGR, CYP19A1
16
Show member pathways
Nuclear Receptors37
8.2ESR1, ESR2, PGR, AR
17
Show member pathways
8.2AR, PGR, ESR2, ESR1

Compounds for genes affiliated with Gender Identity Disorder

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Compounds related to Gender Identity Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 145)
idCompoundScoreTop Affiliating Genes
14-tert-octylphenol449.4ESR2, ESR1, AR
2estramustine44 1110.2ESR1, ESR2, AR
3vinclozolin449.2CYP19A1, AR, ESR1
4aminoglutethimide44 1110.1ESR1, AR, CYP19A1
5trilostane44 1110.0ESR2, PGR, ESR1
6naringenin44 119.9ESR1, CYP19A1, ESR2
7norgestimate44 119.9AR, ESR1, PGR
8idoxifene448.9ESR1, PGR, CYP19A1
9goserelin44 28 1110.8PGR, CYP19A1, ESR1
105alpha-androstane-3alpha,17beta-diol448.8AR, CYP19A1, ESR2, ESR1
11megestrol acetate448.7ESR1, PGR, CYP19A1
12bicalutamide44 61 1110.7ESR2, CYP19A1, AR, ESR1
13cyproteroneacetate448.5PGR, AR, CYP19A1
14estradiol benzoate448.5PGR, CYP19A1, ESR2, ESR1
15leuprolide acetate448.5ESR1, CYP19A1, PGR, ESR2
16anastrozole44 50 1110.5CYP19A1, PGR, ESR2, ESR1
17toremifene44 119.5ESR2, PGR, ESR1, CYP19A1
18clomiphene citrate448.4ESR1, CYP19A1, PGR, ESR2
193beta-hydroxysteroid448.4CYP19A1, PGR, ESR2, AR
20raloxifene44 50 28 1111.4ESR1, PGR, CYP19A1, ESR2
21resveratrol44 61 24 1111.4ESR1, AR, ESR2, PGR
22lapatinib44 50 1110.4AR, ESR1, PGR, CYP19A1
23danazol44 24 1110.4PGR, ESR1, CYP19A1, AR
244-hydroxytamoxifen448.4ESR1, ESR2, PGR, CYP19A1
25flutamide44 61 1110.4PGR, ESR1, CYP19A1, AR
26tibolone448.2ESR1, CYP19A1, PGR
27docetaxel44 50 61 1111.2AR, PGR, ESR1, CYP19A1
285-aza-2deoxycytidine448.1ESR2, PGR, ESR1, AR
29nandrolone44 249.0AR, ESR1, ESR2, PGR, CYP19A1
30exemestane44 50 61 1111.0ESR1, AR, PGR, CYP19A1, ESR2
31bisphenol a448.0AR, CYP19A1, ESR1, ESR2, PGR
32fulvestrant44 50 28 1111.0CYP19A1, PGR, ESR2, ESR1, AR
33letrozole44 50 61 1111.0PGR, ESR2, ESR1, AR, CYP19A1
34levonorgestrel44 61 28 1111.0PGR, CYP19A1, AR, ESR1, ESR2
35steroidal448.0AR, ESR1, CYP19A1, PGR, ESR2
36diethylstilbestrol44 28 1110.0CYP19A1, PGR, ESR2, ESR1, AR
3717beta-hydroxysteroid448.0CYP19A1, PGR, ESR2, ESR1, AR
38progestins448.0CYP19A1, PGR, ESR1, AR, ESR2
39progestin448.0CYP19A1, AR, ESR1, ESR2, PGR
40mifepristone44 28 61 1110.9PGR, ESR2, AR, ESR1, CYP19A1
41estrone44 28 24 1110.9ESR1, AR, CYP19A1, PGR, ESR2
42dihydrotestosterone44 28 24 1110.9ESR1, AR, PGR, ESR2, CYP19A1
43gnrh447.9ESR1, CYP19A1, AR, ESR2, PGR
44tamoxifen44 50 28 1110.9PGR, ESR1, AR, ESR2, CYP19A1
45doxorubicin44 50 119.8PGR, AR, CYP19A1, ESR2, ESR1
46estradiol44 24 119.8ESR2, AR, PGR, CYP19A1, ESR1
47genistein44 28 61 2 24 1112.8CYP19A1, PGR, ESR2, AR, ESR1
48cycloheximide447.7PGR, CYP19A1, ESR1, AR, ESR2
49progesterone44 28 61 24 1111.6ESR2, PGR, CYP19A1, AR, ESR1
50testosterone44 61 24 1110.5AR, ESR1, ESR2, PGR, CYP19A1

GO Terms for genes affiliated with Gender Identity Disorder

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Cellular components related to Gender Identity Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056548.2AR, ESR1, ESR2, PGR

Biological processes related to Gender Identity Disorder according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1uterus developmentGO:0600659.7ESR1, ESR2
2vagina developmentGO:0600689.6ESR2, ESR1
3intracellular estrogen receptor signaling pathwayGO:0305209.6ESR2, ESR1
4positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.5ESR1, ESR2
5androgen metabolic processGO:0082099.4ESR1, CYP19A1
6negative regulation of gene expressionGO:0106298.8ESR1, PGR
7cell-cell signalingGO:0072678.7PGR, AR, ESR2
8transcription initiation from RNA polymerase II promoterGO:0063678.4AR, ESR1, ESR2, PGR
9gene expressionGO:0104678.3PGR, ESR2, ESR1, AR
10signal transductionGO:0071658.1ESR2, PGR, AR, ESR1

Molecular functions related to Gender Identity Disorder according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1estrogen response element bindingGO:0340569.6ESR1, ESR2
2estrogen receptor activityGO:0302849.5ESR2, ESR1
3beta-catenin bindingGO:0080139.4AR, ESR1
4core promoter sequence-specific DNA bindingGO:0010469.4ESR1, ESR2
5steroid bindingGO:0054968.9ESR1, PGR, ESR2
6ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:0048798.9AR, ESR2, PGR
7steroid hormone receptor activityGO:0037078.8PGR, ESR2, ESR1
8enzyme bindingGO:0198998.3ESR1, ESR2, PGR, AR
9zinc ion bindingGO:0082707.9PGR, ESR2, ESR1, AR

Products for genes affiliated with Gender Identity Disorder

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  • Antibodies
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Sources for Gender Identity Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet