MCID: GND002
MIFTS: 42

Gender Identity Disorder malady

Categories: Mental diseases

Aliases & Classifications for Gender Identity Disorder

Aliases & Descriptions for Gender Identity Disorder:

Name: Gender Identity Disorder 12 14
Psychosexual Identity Disorder 69

Classifications:



External Ids:

Disease Ontology 12 DOID:1234
ICD10 33 F64.2 F64
SNOMED-CT 64 5095008

Summaries for Gender Identity Disorder

Disease Ontology : 12 A disease of mental health that involves a conflict between a person's actual physical gender and the gender that person identifies himself or herself as.

MalaCards based summary : Gender Identity Disorder, also known as psychosexual identity disorder, is related to substance abuse and transsexualism. An important gene associated with Gender Identity Disorder is CYP19A1 (Cytochrome P450 Family 19 Subfamily A Member 1), and among its related pathways/superpathways are Glioma and Integrated Breast Cancer Pathway. The drugs Dutasteride and Estradiol have been mentioned in the context of this disorder. Affiliated tissues include bone, and related phenotypes are endocrine/exocrine gland and behavior/neurological

Related Diseases for Gender Identity Disorder

Diseases related to Gender Identity Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 139)
id Related Disease Score Top Affiliating Genes
1 substance abuse 29.6 ESR1 ESR2
2 transsexualism 11.5
3 ego-dystonic sexual orientation 10.9
4 transvestism 10.7
5 dystonia-parkinsonism, x-linked 10.2 AR CYP19A1
6 glioblastoma mesenchymal subtype 10.2 AR CYP19A1
7 leukoencephalopathy with ataxia 10.2 AR CYP19A1
8 malignant teratocarcinosarcoma 10.2 AR ESR2
9 biemond syndrome 10.2 CYP19A1 PGR
10 panophthalmitis 10.2 CYP19A1 PGR
11 congenital articular rigidity 10.2 AR CYP19A1
12 mature teratoma 10.2 AR ESR2
13 sphingolipidosis 10.2 AR CYP19A1
14 third ventricle chordoid glioma 10.2 AR CYP19A1
15 reactive arthritis 10.2 ESR2 PGR
16 bowman's membrane folds or rupture 10.2 AR PGR
17 bone marrow cancer 10.2 AR PGR
18 exocervical carcinoma 10.2 AR ESR2
19 celiac disease 12 10.2 CYP19A1 ESR1
20 laryngeal neuroendocrine tumor 10.1 AR PGR
21 endocervicitis 10.1 ESR2 PGR
22 adams-oliver syndrome 6 10.1 CYP19A1 ESR1
23 hypospadias 1, x-linked 10.1 AR CYP19A1
24 neuroschistosomiasis 10.1 ESR1 ESR2
25 larynx leiomyoma 10.1 CYP19A1 ESR1
26 x-linked leigh syndrome 10.1 AR ESR1
27 liver sarcoma 10.1 CYP19A1 ESR1
28 bartholin's gland benign neoplasm 10.1 ESR1 PGR
29 skin hemangioma 10.1 AR CYP19A1
30 cardiovascular organ benign neoplasm 10.1 ESR1 PGR
31 appendix leiomyoma 10.1 ESR1 PGR
32 bronchus adenoma 10.1 ESR1 PGR
33 glioma 10.1 ESR1 PGR
34 ovarian benign neoplasm 10.1 ESR1 PGR
35 gallbladder papillomatosis 10.1 ESR2 PGR
36 plexiform neurofibroma 10.1 ESR1 PGR
37 paranasal sinus disease 10.1 ESR1 PGR
38 cervical lymphoepithelioma-like carcinoma 10.1 ESR1 PGR
39 histiocytic and dendritic cell cancer 10.1 ESR1 PGR
40 atypical lipomatous tumor 10.1 ESR1 PGR
41 pediatric intraocular retinoblastoma 10.1 ESR1 PGR
42 congenital disorder of glycosylation, type ic 10.1 ESR1 PGR
43 gaucher's disease 10.1 AR CYP19A1
44 intestinal perforation 10.1 ESR1 PGR
45 perlman syndrome 10.1 ESR1 PGR
46 sex differentiation disease 10.1 CYP19A1 PGR
47 bladder adenocarcinoma 10.1 ESR1 PGR
48 vulva basal cell carcinoma 10.1 ESR1 PGR
49 villoglandular endometrial endometrioid adenocarcinoma 10.1 ESR1 PGR
50 vaginal adenosarcoma 10.1 ESR1 PGR

Graphical network of the top 20 diseases related to Gender Identity Disorder:



Diseases related to Gender Identity Disorder

Symptoms & Phenotypes for Gender Identity Disorder

MGI Mouse Phenotypes related to Gender Identity Disorder:

44 (show all 15)
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.04 AR CYP19A1 ESR1 ESR2 PGR RFX6
2 behavior/neurological MP:0005386 10.01 AR CYP19A1 ESR1 ESR2 PGR RFX6
3 cardiovascular system MP:0005385 10 AR CYP19A1 ESR1 ESR2 PGR RPGRIP1L
4 adipose tissue MP:0005375 9.95 AR CYP19A1 ESR1 ESR2 RPGRIP1L
5 growth/size/body region MP:0005378 9.95 AR CYP19A1 ESR1 ESR2 RFX6 RPGRIP1L
6 digestive/alimentary MP:0005381 9.91 AR CYP19A1 ESR1 ESR2 RFX6
7 integument MP:0010771 9.85 AR CYP19A1 ESR1 ESR2 PGR
8 limbs/digits/tail MP:0005371 9.83 AR ESR1 ESR2 PGR RPGRIP1L
9 liver/biliary system MP:0005370 9.8 ESR1 ESR2 RPGRIP1L AR CYP19A1
10 muscle MP:0005369 9.77 AR CYP19A1 ESR1 ESR2 PGR
11 normal MP:0002873 9.65 AR CYP19A1 ESR1 ESR2 PGR
12 neoplasm MP:0002006 9.62 AR ESR1 ESR2 PGR
13 renal/urinary system MP:0005367 9.55 AR CYP19A1 ESR1 ESR2 RPGRIP1L
14 reproductive system MP:0005389 9.35 AR CYP19A1 ESR1 ESR2 PGR
15 skeleton MP:0005390 9.1 AR CYP19A1 ESR1 ESR2 PGR RPGRIP1L

Drugs & Therapeutics for Gender Identity Disorder

Drugs for Gender Identity Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 66)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dutasteride Approved, Investigational Phase 3 164656-23-9 152945 6918296
2
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757 53477783
3
Letrozole Approved, Investigational Phase 3 112809-51-5 3902
4
Methyltestosterone Approved Phase 3 58-18-4 6010
5
Testosterone Approved, Investigational Phase 3 58-22-0 6013
6
Dihydrotestosterone Illicit Phase 3 521-18-6 10635
7 5-alpha Reductase Inhibitors Phase 3
8 Anabolic Agents Phase 3
9 Androgens Phase 3
10 Antineoplastic Agents, Hormonal Phase 3
11 Aromatase Inhibitors Phase 3
12 Estradiol 17 beta-cypionate Phase 3
13 Estradiol 3-benzoate Phase 3
14 Estradiol valerate Phase 3 979-32-8
15 Estrogen Antagonists Phase 3
16 Estrogens Phase 3
17 Hormone Antagonists Phase 3
18 Hormones Phase 3
19 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
20 Polyestradiol phosphate Phase 3
21 Steroid Synthesis Inhibitors Phase 3
22 Testosterone 17 beta-cypionate Phase 3
23
Testosterone enanthate Phase 3 315-37-7 9416
24 Testosterone undecanoate Phase 3
25
Emtricitabine Approved, Investigational Phase 2 143491-57-0 60877
26
Tenofovir Approved, Investigational Phase 2 147127-20-6 464205
27
Ethanol Approved Phase 2 64-17-5 702
28 Anti-HIV Agents Phase 2
29 Anti-Infective Agents Phase 2
30 Anti-Retroviral Agents Phase 2
31 Antiviral Agents Phase 2
32 Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Phase 2
33 Nucleic Acid Synthesis Inhibitors Phase 2
34 Reverse Transcriptase Inhibitors Phase 2
35 Vaccines Phase 2
36
Cyproterone Acetate Approved, Investigational 427-51-0
37
Desogestrel Approved 54024-22-5 40973
38
Hydrocortisone Approved, Vet_approved 50-23-7 5754 657311
39
Leuprolide Approved, Investigational 53714-56-0 3911 657181
40
Nicotine Approved 54-11-5 942 89594
41
Methylphenidate Approved, Investigational 113-45-1 4158
42
Acetazolamide Approved, Vet_approved 59-66-5 1986
43
Finasteride Approved 98319-26-7 57363
44
Menthol Approved 2216-51-5 16666
45
Cyproterone 2098-66-0 5284537
46 lynestrenol
47 Cortisol succinate
48 Hydrocortisone 17-butyrate 21-propionate
49 Hydrocortisone acetate
50 Contraceptive Agents

Interventional clinical trials:

(show all 26)
id Name Status NCT ID Phase
1 Testosterone and Its Metabolites in GID Completed NCT00146146 Phase 3
2 An Open Label Demonstration Project and Phase II Safety Study of Pre-Exposure Prophylaxis Unknown status NCT01772823 Phase 2
3 An HIV Intervention for Black Men at Risk - The Enhanced Sexual Health Intervention for Men (ES-HIM) Completed NCT01641146 Phase 2
4 A Peer-Oriented HIV Prevention Outreach Program for Individuals at High Risk for HIV and Other STIs Completed NCT00183456 Phase 2
5 Effectiveness of Two Hepatitis B Vaccines in HIV-negative Youths Completed NCT00107042 Phase 2
6 An Open Label Demonstration Project and Phase II Safety Study of Pre-Exposure Prophylaxis Use Among 15 to 17 Year Old Young Men Who Have Sex With Men (YMSM) Completed NCT01769456 Phase 2
7 Effects of Sex Steroid Hormones on Human Brain Function, Structure and Connectivity Completed NCT01292785
8 CVD Risk Factors and Sexual Identity in Women Completed NCT00058669
9 GrOup-based Physical Activity for oLder Adults Trial Completed NCT02023632
10 Motiv82Change: an HIV Prevention Study for Young Latino Men Completed NCT00877695
11 Culturally-Tailored HIV Risk Reduction for African-American MSM Completed NCT00691561
12 Pathophysiology of Chronic Wounds Completed NCT00006437
13 Observational Study on Metabolism and Psychopathology in Transsexual Patients Recruiting NCT02185274
14 Evaluating the Neurobiological Basis of Traumatic Dissociation in Women With Histories of Abuse and Neglect Recruiting NCT02757339
15 GEnder Dysphoria Treatment in Sweden Recruiting NCT02518009
16 Values of Enhanced Monitoring by EEG Recording (Narcotrend) for Sedation in Colonoscopy Recruiting NCT02687568
17 Values of Enhanced Monitoring by EEG Recording (Narcotrend) for Sedation in Endoscopic Ultrasound Recruiting NCT02705079
18 The Relation of GnRH Treatment to QTc Interval in Transgender Females Recruiting NCT03078829
19 Study of Familiarity in Alcohol Dependence Recruiting NCT02881424
20 Connecting Youth and Young Adults to Optimize ART Adherence: YouTHrive Efficacy Trial Recruiting NCT03149757
21 Personality Pathology and Cerebral Processing in Eating Disorders Recruiting NCT02980120
22 French Study on COgnitive Enhancement and Consumption of Psychoactive Substances Among Youth Students Recruiting NCT02954679
23 Sleep Apnea in Elderly Recruiting NCT02703220
24 An Assessment of an HIV Prevention Intervention (Project AIM) Among Junior Secondary School Students in Eastern Botswana Active, not recruiting NCT02455583
25 Health Improvement for Baltimore Youth Enrolling by invitation NCT02624193
26 Integrating Use of Self-Affirmation Content Into a Mobile App to Promote Quit Attempts With Text-Based Smoking Cessation Intervention Messaging Not yet recruiting NCT03027466 Early Phase 1

Search NIH Clinical Center for Gender Identity Disorder

Genetic Tests for Gender Identity Disorder

Anatomical Context for Gender Identity Disorder

MalaCards organs/tissues related to Gender Identity Disorder:

39
Bone

Publications for Gender Identity Disorder

Articles related to Gender Identity Disorder:

(show top 50) (show all 177)
id Title Authors Year
1
Minnesota Multiphasic Personality Inventory-2 Profiles of Patients with Gender Identity Disorder Requesting Sex Reassignment Surgery. ( 27833228 )
2016
2
Genetic and Environmental Influences on Traits of Gender Identity Disorder: A Study of Japanese Twins Across Developmental Stages. ( 27507021 )
2016
3
Gender typicality in children's speech: A comparison of boys with and without gender identity disorder. ( 25920850 )
2015
4
Long-Term Follow-Up of Adults with Gender Identity Disorder. ( 25690443 )
2015
5
Comparison of Masculine and Feminine Gender Roles in Iranian Patients with Gender Identity Disorder. ( 26797060 )
2015
6
Eleven-year follow up of boy with Asperger's syndrome and comorbid gender identity disorder of childhood. ( 26126993 )
2015
7
Personality disorders in persons with gender identity disorder. ( 24959629 )
2014
8
The frequency of personality disorders in patients with gender identity disorder. ( 25664291 )
2014
9
Gender identity disorder and autism spectrum disorder in a 23-year-old female. ( 23835847 )
2014
10
Management challenges in a case of gender identity disorder. ( 25788806 )
2014
11
Differences in personality traits between male-to-female and female-to-male gender identity disorder subjects. ( 25130781 )
2014
12
Effects of different steps in gender reassignment therapy on psychopathology: a prospective study of persons with a gender identity disorder. ( 24344788 )
2014
13
Gender identity disorder and schizophrenia: neurodevelopmental disorders with common causal mechanisms? ( 25548672 )
2014
14
Click-evoked otoacoustic emissions in children and adolescents with gender identity disorder. ( 24567168 )
2014
15
Substance abuse as a way of life in marginalized gender identity disorder: A case report with review of Indian literature. ( 25311662 )
2014
16
Risk factors for the development of well leg compartment syndrome after sex reassignment surgery in patients with gender identity disorder. ( 24286463 )
2013
17
Parent-child relationships in gender identity disorder. ( 23959770 )
2013
18
Serum concentrations of brain-derived neurotrophic factor in patients with gender identity disorder. ( 23702250 )
2013
19
Current management of gender identity disorder in childhood and adolescence: guidelines, barriers and areas of controversy. ( 23221495 )
2013
20
Memo outlining evidence for change for gender identity disorder in the DSM-5. ( 23868018 )
2013
21
Prevalence of gender identity disorder and suicide risk among transgender veterans utilizing veterans health administration care. ( 23947310 )
2013
22
Hormonal treatment reduces psychobiological distress in gender identity disorder, independently of the attachment style. ( 23574768 )
2013
23
Testosterone replacement elevates the serum uric acid levels in patients with female to male gender identity disorder. ( 24047564 )
2013
24
Editorial Comment to Risk factors for the development of well leg compartment syndrome after sex reassignment surgery in patients with gender identity disorder. ( 24341964 )
2013
25
Dose-response analysis of testosterone replacement therapy in patients with female to male gender identity disorder. ( 23117148 )
2013
26
Gender identity disorder and eating disorders: similarities and differences in terms of body uneasiness. ( 23347389 )
2013
27
Sociodemographic and clinical features of gender identity disorder: an Italian multicentric evaluation. ( 23171237 )
2013
28
Lay theories of gender identity disorder. ( 24059967 )
2013
29
School refusal by patients with gender identity disorder. ( 22227029 )
2012
30
First Transsexualism European Meeting : Psychological, Medical and Surgical management in gender identity disorder. An international highlight 17 (th) -18 (th) May 2012 Dental School, Turin, Italy. ( 27517686 )
2012
31
Sliding Doors: should treatment of gender identity disorder and other body modifications be privately funded? ( 21132536 )
2012
32
From gender identity disorder to gender identity creativity: true gender self child therapy. ( 22455324 )
2012
33
Treatment of gender identity disorder. ( 22854940 )
2012
34
A developmental, biopsychosocial model for the treatment of children with gender identity disorder. ( 22455326 )
2012
35
Hormone treatment of gender identity disorder in a cohort of children and adolescents. Comment. ( 22938118 )
2012
36
Hormone treatment of gender identity disorder in a cohort of children and adolescents. ( 22621149 )
2012
37
Children and adolescents with gender identity disorder referred to a pediatric medical center. ( 22351896 )
2012
38
Editorial Comment to Status of sex reassignment surgery for gender identity disorder in Japan. ( 22416672 )
2012
39
Disordered eating and gender identity disorder: a qualitative study. ( 22703571 )
2012
40
Leave to intervene in cases of gender identity disorder; normative causation; financial harms and involuntary treatment; and the right to be protected from suicide. ( 23180326 )
2012
41
Social dichotomy versus gender dichotomy: a case report of gender identity disorder. ( 23162201 )
2012
42
Sexual medicine: Can pelvic measurements predict gender identity disorder? ( 22868994 )
2012
43
Pediatrics: evaluation and management of gender identity disorder--an American tale. ( 22410681 )
2012
44
Report of the American Psychiatric Association Task Force on Treatment of Gender Identity Disorder. ( 22736225 )
2012
45
A study of changes in bone metabolism in cases of gender identity disorder. ( 22222419 )
2012
46
Hormone treatment of gender identity disorder in a cohort of children and adolescents. Comment. ( 22938117 )
2012
47
Demographics, behavior problems, and psychosexual characteristics of adolescents with gender identity disorder or transvestic fetishism. ( 22390530 )
2012
48
Gender identity disorder: an emerging problem for pediatricians. ( 22351880 )
2012
49
Gender identity disorder in twins: a review of the case report literature. ( 22146048 )
2012
50
Childhood maltreatment in subjects with male-to-female gender identity disorder. ( 21833007 )
2011

Variations for Gender Identity Disorder

Expression for Gender Identity Disorder

Search GEO for disease gene expression data for Gender Identity Disorder.

Pathways for Gender Identity Disorder

GO Terms for Gender Identity Disorder

Biological processes related to Gender Identity Disorder according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.81 AR ESR1 PGR RFX6
2 positive regulation of transcription, DNA-templated GO:0045893 9.73 AR ESR1 ESR2 RFX6
3 cell-cell signaling GO:0007267 9.67 AR ESR2 PGR
4 intracellular receptor signaling pathway GO:0030522 9.48 AR ESR1
5 intracellular estrogen receptor signaling pathway GO:0030520 9.46 ESR1 ESR2
6 mammary gland alveolus development GO:0060749 9.4 AR ESR1
7 androgen metabolic process GO:0008209 9.37 CYP19A1 ESR1
8 uterus development GO:0060065 9.32 CYP19A1 ESR1
9 prostate gland growth GO:0060736 9.26 AR CYP19A1
10 transcription initiation from RNA polymerase II promoter GO:0006367 9.26 AR ESR1 ESR2 PGR
11 tertiary branching involved in mammary gland duct morphogenesis GO:0060748 9.16 AR PGR
12 steroid hormone mediated signaling pathway GO:0043401 8.92 AR ESR1 ESR2 PGR

Molecular functions related to Gender Identity Disorder according to GeneCards Suite gene sharing:

(show all 16)
id Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.95 AR ESR1 ESR2 PGR RFX6
2 zinc ion binding GO:0008270 9.86 AR ESR1 ESR2 PGR
3 transcription factor activity, sequence-specific DNA binding GO:0003700 9.84 AR ESR1 ESR2 PGR
4 sequence-specific DNA binding GO:0043565 9.8 AR ESR1 ESR2 PGR
5 enzyme binding GO:0019899 9.78 AR ESR1 ESR2 PGR
6 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 9.76 AR ESR1 PGR RFX6
7 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077 9.69 AR ESR1 PGR
8 lipid binding GO:0008289 9.67 AR ESR1 ESR2 PGR
9 ATPase binding GO:0051117 9.61 AR ESR1 PGR
10 core promoter sequence-specific DNA binding GO:0001046 9.52 ESR1 ESR2
11 steroid hormone receptor activity GO:0003707 9.46 AR ESR1 ESR2 PGR
12 estrogen receptor activity GO:0030284 9.4 ESR1 ESR2
13 estrogen response element binding GO:0034056 9.32 ESR1 ESR2
14 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding GO:0038052 9.26 ESR1 ESR2
15 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0004879 9.26 AR ESR1 ESR2 PGR
16 steroid binding GO:0005496 8.92 AR ESR1 ESR2 PGR

Sources for Gender Identity Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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