MCID: GND002
MIFTS: 51

Gender Identity Disorder malady

Mental diseases category
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Summaries for Gender Identity Disorder

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Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A disease of mental health that involves a conflict between a person's actual physical gender and the gender that person identifies himself or herself as.

MalaCards: Gender Identity Disorder, also known as psychosexual identity disorder, is related to transsexualism and transvestism. An important gene associated with Gender Identity Disorder is RPGRIP1L (RPGRIP1-like), and among its related pathways are Plasma membrane estrogen receptor signaling and Assembly of RNA Polymerase-II Initiation Complex. The compounds 4-tert-octylphenol and estramustine have been mentioned in the context of this disorder. Affiliated tissues include brain and bone, and related mouse phenotypes are renal/urinary system and adipose tissue.

Wikipedia:65 Gender dysphoria or gender identity disorder (GID) is the former diagnosis used by psychologists and... more...

Aliases & Classifications for Gender Identity Disorder

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Sources:
8Disease Ontology, 10DISEASES, 62UMLS, 27ICD9CM, 58SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

gender identity disorder 8 10
psychosexual identity disorder 62


External Ids:

Disease Ontology8 DOID:1234
ICD9CM27 302.89, 302.8
SNOMED-CT58 5095008
ICD1025 F64

Related Diseases for Gender Identity Disorder

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Gender Identity Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1transsexualism10.6
2transvestism10.3
3anorexia nervosa10.3
4asperger syndrome10.3
5autism spectrum disorder10.3
6compartment syndrome10.3
7eating disorder10.3
8schizophrenia10.3
9obsessive-compulsive disorder10.1
10cerebritis10.1
11ego-dystonic sexual orientation10.1
12parkinson's disease10.1
13fetishism10.1
14hepatitis10.1
15androgen insensitivity syndrome10.1AR
16cerebral meningioma10.1PGR
17germ cell cancer10.0ESR2, AR
18ovarian cyst10.0CYP19A1, ESR2
19partial androgen insensitivity syndrome10.0AR, CYP19A1
20complete androgen insensitivity syndrome10.0AR, CYP19A1
21uterine sarcoma10.0ESR1, CYP19A1
22androgenic alopecia10.0AR, CYP19A1
23prostate disease10.0CYP19A1, AR
24pseudohermaphroditism10.0AR, CYP19A1
25ovarian disease10.0CYP19A1, ESR1
26progesterone resistance10.0PGR, ESR1
27abrikosov's tumor10.0CYP19A1, ESR1
28adenosarcoma10.0ESR1, PGR
29polycystic ovary syndrome10.0AR, CYP19A1
30meningioma10.0PGR, ESR1
31cribriform carcinoma10.0PGR, ESR1
32prolactinoma10.0ESR1, ESR2
33mammary paget's disease10.0PGR, ESR1
34malignant mixed mullerian tumor10.0PGR, ESR1
35cryptorchidism10.0AR, CYP19A1
36bilateral breast cancer10.0PGR, ESR1
37factor vii deficiency10.0CYP19A1, ESR1
38leiomyomatosis10.0ESR1, PGR
39li-fraumeni syndrome10.0PGR, ESR1
40uterine fibroid10.0PGR, ESR1
41pituitary tumors10.0ESR1, ESR2
42inflammatory breast carcinoma10.0ESR1, PGR
43lymphangioleiomyomatosis10.0ESR1, PGR
44klinefelter's syndrome10.0CYP19A1, AR
45angiomyolipoma10.0PGR, ESR1
46estrogen excess10.0CYP19A1, PGR
47cervical adenocarcinoma10.0PGR, ESR1
48breast cancer, invasive ductal10.0PGR, ESR1
49fibromatosis10.0PGR, AR
50hyperandrogenism10.0AR, CYP19A1

Graphical network of the top 20 diseases related to Gender Identity Disorder:



Diseases related to gender identity disorder

Symptoms for Gender Identity Disorder

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Drugs & Therapeutics for Gender Identity Disorder

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Sources:
42NIH Clinical Center, 6ClinicalTrials
See all sources

Drug clinical trials:

Search ClinicalTrials for Gender Identity Disorder

Search NIH Clinical Center for Gender Identity Disorder

Genetic Tests for Gender Identity Disorder

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Anatomical Context for Gender Identity Disorder

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Sources:
33MalaCards
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MalaCards organs/tissues related to Gender Identity Disorder:

33
Brain, Bone

Animal Models for Gender Identity Disorder or affiliated genes

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Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Gender Identity Disorder:

37 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.7AR, RPGRIP1L, ESR1, ESR2
2MP:00053758.6AR, ESR1, ESR2, CYP19A1
3MP:00053718.5PGR, ESR2, ESR1, RPGRIP1L
4MP:00020068.4AR, ESR1, ESR2, PGR
5MP:00053708.3CYP19A1, ESR2, ESR1, RPGRIP1L, AR
6MP:00053808.1PGR, ESR1, RPGRIP1L, AR
7MP:00036318.1CYP19A1, ESR2, ESR1, RPGRIP1L, AR
8MP:00053788.0AR, RPGRIP1L, ESR1, ESR2, CYP19A1
9MP:00053697.8CYP19A1, PGR, ESR2, ESR1, AR
10MP:00053897.8CYP19A1, PGR, ESR2, ESR1, AR
11MP:00028737.8CYP19A1, PGR, ESR2, AR
12MP:00053977.8CYP19A1, PGR, ESR2, ESR1, AR
13MP:00107687.7AR, RPGRIP1L, ESR1, ESR2, PGR
14MP:00053867.7CYP19A1, PGR, ESR2, ESR1, AR
15MP:00053877.7CYP19A1, PGR, ESR2, ESR1, AR
16MP:00053767.5CYP19A1, PGR, ESR2, ESR1, AR
17MP:00053797.5AR, RPGRIP1L, ESR1, ESR2, PGR, CYP19A1
18MP:00053907.5CYP19A1, PGR, ESR2, ESR1, RPGRIP1L, AR
19MP:00107717.5CYP19A1, PGR, ESR2, ESR1, RPGRIP1L, AR
20MP:00053857.4CYP19A1, PGR, ESR2, ESR1, RPGRIP1L, AR
21MP:00053847.4CYP19A1, PGR, ESR2, ESR1, RPGRIP1L, AR

Publications for Gender Identity Disorder

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Sources:
52PubMed
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Articles related to Gender Identity Disorder:

(show top 50)    (show all 161)
idTitleAuthorsYear
1
Testosterone replacement elevates the serum uric acid levels in patients with female to male gender identity disorder. (24047564)
2013
2
Serum concentrations of brain-derived neurotrophic factor in patients with gender identity disorder. (23702250)
2013
3
Gender identity disorder and eating disorders: similarities and differences in terms of body uneasiness. (23347389)
2013
4
Hormone treatment of gender identity disorder in a cohort of children and adolescents. Comment. (22938118)
2012
5
Hormone treatment of gender identity disorder in a cohort of children and adolescents. Comment. (22938117)
2012
6
Report of the American Psychiatric Association Task Force on Treatment of Gender Identity Disorder. (22736225)
2012
7
Social dichotomy versus gender dichotomy: a case report of gender identity disorder. (23162201)
2012
8
Gender identity disorder in twins: a review of the case report literature. (22146048)
2012
9
Editorial Comment to Status of sex reassignment surgery for gender identity disorder in Japan. (22416672)
2012
10
Puberty suppression in gender identity disorder: the Amsterdam experience. (21587245)
2011
11
Where Christ did not go: men, women and Frusculicchi. Gender identity disorder (GID): epistemological and ethical issues relating to the psychiatric diagnosis. (22397088)
2011
12
Dysfunctional core beliefs, perceived parenting behavior and psychopathology in gender identity disorder: A comparison of male-to-female, female-to-male transsexual and nontranssexual control subjects. (21074005)
2011
13
Assessing the utility of diagnostic criteria: a multisite study on gender identity disorder. (20946149)
2011
14
Childhood maltreatment in subjects with male-to-female gender identity disorder. (21833007)
2011
15
Endocrine disruptors, the increase of autism spectrum disorder and its comorbidity with gender identity disorder--a hypothetical association. (21950370)
2011
16
Regional cerebral blood flow changes in female to male gender identity disorder. (20132527)
2010
17
Proposed revisions to gender identity disorder diagnoses in the DSM-5. (20725853)
2010
18
Schizophrenia modifying the expression of gender identity disorder. (18069992)
2009
19
Gender identity disorder in children and adolescents. (19380105)
2009
20
When attachment disorder presents with symptoms of gender identity disorder: case discussion. (19495434)
2009
21
Empathy in boys with gender identity disorder: a comparison to externalizing clinical control boys and community control boys and girls. (17620006)
2008
22
On the "natural history" of gender identity disorder in children. (19034186)
2008
23
What can the Samoan "Fa'afafine" teach us about the Western concept of gender identity disorder in childhood? (17951883)
2007
24
Psychiatric comorbidity among children with gender identity disorder. (17885572)
2007
25
Gender identity disorder and its medico-legal considerations. (17345887)
2007
26
Gender identity disorder. Is this a potentially fatal condition? (18693618)
2007
27
Gender identity disorder. (16892921)
2006
28
Nursing experience of redesigning a schedule to consider gender identity disorder in recruits' physical examination. (17102318)
2006
29
Donor-site morbidity of the radial forearm free flap after 125 phalloplasties in gender identity disorder. (17016186)
2006
30
Clinical and theoretical parallels between desire for limb amputation and gender identity disorder. (16799838)
2006
31
Gender identity disorder: general overview and surgical treatment for vaginoplasty in male-to-female transsexuals. (16267416)
2005
32
Cross-sex hormone treatment does not change sex-sensitive cognitive performance in gender identity disorder patients. (16297984)
2005
33
Adoption in boys with gender identity disorder. (12921464)
2003
34
Demographic characteristics, social competence, and behavior problems in children with gender identity disorder: a cross-national, cross-clinic comparative analysis. (12597698)
2003
35
Gender identity disorder presenting in a girl with Asperger's disorder and obsessive compulsive disorder. (12971211)
2003
36
Psychopathology in the parents of boys with gender identity disorder. (12500069)
2003
37
The heritability of gender identity disorder in a child and adolescent twin sample. (12211624)
2002
38
Handedness in boys with gender identity disorder. (11583249)
2001
39
Gender identity disorder in DSM? (11314563)
2001
40
Gender identity disorder. (10361778)
1999
41
Secondary gender identity disorder - a case report. (21455399)
1999
42
Effects of physical appearance on masculine trait ratings of boys and girls with gender identity disorder. (9604115)
1998
43
Gender identity disorder. (9519623)
1998
44
Gender identity disorder and HIV disease. (8031915)
1994
45
The concept of gender identity disorder in childhood and adolescence after 39 years. (7996589)
1994
46
Intersexuality and the diagnosis of gender identity disorder. (8135650)
1994
47
The psychoanalytic treatment of a preschool boy with a gender identity disorder. (2026849)
1991
48
The association of gender identity disorder with parental separation. (2623124)
1989
49
Gender identity disorder of childhood. Introduction. (4067136)
1985
50
Patterns of intellectual functioning and spatial ability in boys and gender identity disorder. (7066844)
1982

Variations for Gender Identity Disorder

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Expression for genes affiliated with Gender Identity Disorder

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Gender Identity Disorder

Search GEO for disease gene expression data for Gender Identity Disorder.

Pathways for genes affiliated with Gender Identity Disorder

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Sources:
50PathCards, 38NCBI BioSystems Database, 53QIAGEN, 30KEGG, 60Thomson Reuters, 55Reactome, 54R&D Systems, 51PharmGKB
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Pathways related to Gender Identity Disorder according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5ESR2, ESR1
2
Show member pathways
9.5ESR1, ESR2
3
Show member pathways
Development Ligand independent activation of ESR1 and ESR260
9.5ESR1, ESR2
49.5ESR1, ESR2
59.5ESR1, ESR2
6
Show member pathways
FOXA transcription factor networks38
9.4ESR1, AR
79.4ESR1, AR
89.3AR, CYP19A1
9
Show member pathways
Cell cycle ESR1 regulation of G1 S transition60
Immune response MIF JAB1 signaling60
Cell cycle Cell cycle generic schema 60
9.1ESR1, PGR
10
Show member pathways
9.1ESR1, PGR
119.0ESR2, ESR1, AR
129.0ESR2, ESR1, AR
13
Show member pathways
8.9ESR1, ESR2, CYP19A1
148.8AR, ESR1, CYP19A1
158.6ESR2, PGR, CYP19A1
16
Show member pathways
Nuclear Receptors38
8.2PGR, ESR2, ESR1, AR
17
Show member pathways
8.2PGR, ESR2, ESR1, AR

Compounds for genes affiliated with Gender Identity Disorder

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Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 61Tocris Bioscience, 51PharmGKB, 24HMDB, 3BitterDB
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Compounds related to Gender Identity Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 145)
idCompoundScoreTop Affiliating Genes
14-tert-octylphenol459.4ESR2, ESR1, AR
2estramustine45 1110.2ESR1, ESR2, AR
3vinclozolin459.2CYP19A1, AR, ESR1
4aminoglutethimide45 1110.1ESR1, AR, CYP19A1
5trilostane45 1110.0ESR2, PGR, ESR1
6naringenin45 119.9ESR1, CYP19A1, ESR2
7norgestimate45 119.9AR, ESR1, PGR
8idoxifene458.9ESR1, PGR, CYP19A1
9goserelin45 29 1110.8PGR, CYP19A1, ESR1
105alpha-androstane-3alpha,17beta-diol458.8AR, CYP19A1, ESR2, ESR1
11megestrol acetate458.7ESR1, PGR, CYP19A1
12bicalutamide45 61 1110.7ESR2, CYP19A1, AR, ESR1
13cyproteroneacetate458.5PGR, AR, CYP19A1
14estradiol benzoate458.5PGR, CYP19A1, ESR2, ESR1
15leuprolide acetate458.5ESR1, CYP19A1, PGR, ESR2
16anastrozole45 51 1110.5CYP19A1, PGR, ESR2, ESR1
17toremifene45 119.5ESR2, PGR, ESR1, CYP19A1
18clomiphene citrate458.4ESR1, CYP19A1, PGR, ESR2
193beta-hydroxysteroid458.4CYP19A1, PGR, ESR2, AR
20raloxifene45 51 29 1111.4ESR1, PGR, CYP19A1, ESR2
21resveratrol45 61 24 1111.4ESR1, AR, ESR2, PGR
22lapatinib45 51 1110.4AR, ESR1, PGR, CYP19A1
23danazol45 24 1110.4PGR, ESR1, CYP19A1, AR
244-hydroxytamoxifen458.4ESR1, ESR2, PGR, CYP19A1
25flutamide45 61 1110.4PGR, ESR1, CYP19A1, AR
26tibolone458.2ESR1, CYP19A1, PGR
27docetaxel45 51 61 1111.2AR, PGR, ESR1, CYP19A1
285-aza-2deoxycytidine458.1ESR2, PGR, ESR1, AR
29nandrolone45 249.0AR, ESR1, ESR2, PGR, CYP19A1
30exemestane45 51 61 1111.0ESR1, AR, PGR, CYP19A1, ESR2
31bisphenol a458.0AR, CYP19A1, ESR1, ESR2, PGR
32fulvestrant45 51 29 1111.0CYP19A1, PGR, ESR2, ESR1, AR
33letrozole45 51 61 1111.0PGR, ESR2, ESR1, AR, CYP19A1
34levonorgestrel45 61 29 1111.0PGR, CYP19A1, AR, ESR1, ESR2
35steroidal458.0AR, ESR1, CYP19A1, PGR, ESR2
36diethylstilbestrol45 29 1110.0CYP19A1, PGR, ESR2, ESR1, AR
3717beta-hydroxysteroid458.0CYP19A1, PGR, ESR2, ESR1, AR
38progestins458.0CYP19A1, PGR, ESR1, AR, ESR2
39progestin458.0CYP19A1, AR, ESR1, ESR2, PGR
40mifepristone45 29 61 1110.9PGR, ESR2, AR, ESR1, CYP19A1
41estrone45 29 24 1110.9ESR1, AR, CYP19A1, PGR, ESR2
42dihydrotestosterone45 29 24 1110.9ESR1, AR, PGR, ESR2, CYP19A1
43gnrh457.9ESR1, CYP19A1, AR, ESR2, PGR
44tamoxifen45 51 29 1110.9PGR, ESR1, AR, ESR2, CYP19A1
45doxorubicin45 51 119.8PGR, AR, CYP19A1, ESR2, ESR1
46estradiol45 24 119.8ESR2, AR, PGR, CYP19A1, ESR1
47genistein45 29 61 3 24 1112.8CYP19A1, PGR, ESR2, AR, ESR1
48cycloheximide457.7PGR, CYP19A1, ESR1, AR, ESR2
49progesterone45 29 61 24 1111.6ESR2, PGR, CYP19A1, AR, ESR1
50testosterone45 61 24 1110.5AR, ESR1, ESR2, PGR, CYP19A1

GO Terms for genes affiliated with Gender Identity Disorder

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Sources:
16Gene Ontology
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Cellular components related to Gender Identity Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056548.2AR, ESR1, ESR2, PGR

Biological processes related to Gender Identity Disorder according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1uterus developmentGO:0600659.7ESR1, ESR2
2vagina developmentGO:0600689.6ESR1, ESR2
3intracellular estrogen receptor signaling pathwayGO:0305209.6ESR1, ESR2
4positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.5ESR1, ESR2
5androgen metabolic processGO:0082099.4CYP19A1, ESR1
6negative regulation of gene expressionGO:0106298.8ESR1, PGR
7cell-cell signalingGO:0072678.7AR, ESR2, PGR
8transcription initiation from RNA polymerase II promoterGO:0063678.4AR, ESR1, ESR2, PGR
9gene expressionGO:0104678.3PGR, ESR2, ESR1, AR
10signal transductionGO:0071658.1PGR, ESR2, ESR1, AR

Molecular functions related to Gender Identity Disorder according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1estrogen response element bindingGO:0340569.6ESR1, ESR2
2estrogen receptor activityGO:0302849.5ESR1, ESR2
3beta-catenin bindingGO:0080139.4AR, ESR1
4core promoter sequence-specific DNA bindingGO:0010469.4ESR2, ESR1
5steroid bindingGO:0054968.9ESR1, ESR2, PGR
6ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:0048798.9PGR, ESR2, AR
7steroid hormone receptor activityGO:0037078.8PGR, ESR2, ESR1
8enzyme bindingGO:0198998.3AR, ESR1, ESR2, PGR
9zinc ion bindingGO:0082707.9AR, ESR1, ESR2, PGR

Products for genes affiliated with Gender Identity Disorder

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  • Antibodies
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  • Lysates
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Sources for Gender Identity Disorder

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet