MCID: GND002
MIFTS: 43

Gender Identity Disorder malady

Mental diseases category

Summaries for Gender Identity Disorder

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Disease Ontology:9 A disease of mental health that involves a conflict between a person's actual physical gender and the gender that person identifies himself or herself as.

MalaCards based summary: Gender Identity Disorder, also known as psychosexual identity disorder, is related to transsexualism and androgen insensitivity. An important gene associated with Gender Identity Disorder is RPGRIP1L (RPGRIP1-like), and among its related pathways are Plasma membrane estrogen receptor signaling and Assembly of RNA Polymerase-II Initiation Complex. The compounds 4-tert-octylphenol and estramustine have been mentioned in the context of this disorder. Affiliated tissues include brain and bone, and related mouse phenotypes are renal/urinary system and adipose tissue.

Wikipedia:63 Gender identity disorder (GID) or gender dysphoria is the formal diagnosis used by psychologists and... more...

Aliases & Classifications for Gender Identity Disorder

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Gender Identity Disorder, Aliases & Descriptions:

Name: Gender Identity Disorder 9 11
 
Psychosexual Identity Disorder 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


External Ids:

Disease Ontology9 DOID:1234
ICD9CM27 302.8, 302.89
SNOMED-CT55 5095008
ICD1025 F64

Related Diseases for Gender Identity Disorder

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Diseases related to Gender Identity Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 76)
idRelated DiseaseScoreTop Affiliating Genes
1transsexualism10.6
2androgen insensitivity10.4AR
3schizophrenia10.4
4anorexia nervosa10.3
5transvestism10.3
6asperger syndrome10.3
7autism spectrum disorder10.3
8compartment syndrome10.3
9eating disorder10.3
10personality disorder10.3
11cerebral meningioma10.3PGR
12germ cell cancer10.2AR, ESR2
13prostatic hypertrophy10.2AR, ESR2
14ovarian cyst10.2CYP19A1, ESR2
15androgen insensitivity, partial, with or without breast cancer10.2AR, CYP19A1
16complete androgen insensitivity syndrome10.1CYP19A1, AR
17obsessive-compulsive disorder10.1
18hepatitis10.1
19cerebritis10.1
20ego-dystonic sexual orientation10.1
21fetishism10.1
22substance abuse10.1
23uterine sarcoma10.1ESR1, CYP19A1
24alopecia, androgenetic, 110.1AR, CYP19A1
25prostate disease10.1AR, CYP19A1
26pseudohermaphroditism10.1CYP19A1, AR
27ovarian disease10.1CYP19A1, ESR1
28progesterone resistance10.1ESR1, PGR
29adenosarcoma10.1ESR1, PGR
30abrikosov's tumor10.1CYP19A1, ESR1
31meningioma, familial10.1ESR1, PGR
32polycystic ovary syndrome10.1CYP19A1, AR
33cribriform carcinoma10.1ESR1, PGR
34mammary paget's disease10.1PGR, ESR1
35prolactinoma10.1ESR2, ESR1
36malignant mixed mullerian tumor10.1PGR, ESR1
37bilateral breast cancer10.1ESR1, PGR
38cryptorchidism10.1CYP19A1, AR
39factor vii deficiency10.0ESR1, CYP19A1
40breast disease10.0PGR, ESR1
41leiomyomatosis10.0ESR1, PGR
42uterine fibroid10.0ESR1, PGR
43pituitary tumors10.0ESR2, ESR1
44inflammatory breast carcinoma10.0ESR1, PGR
45lymphangioleiomyomatosis10.0PGR, ESR1
46klinefelter's syndrome10.0CYP19A1, AR
47angiomyolipoma10.0PGR, ESR1
48estrogen excess10.0PGR, CYP19A1
49breast cancer10.0PGR, ESR1
50cervical adenocarcinoma10.0PGR, ESR1

Graphical network of the top 20 diseases related to Gender Identity Disorder:



Diseases related to gender identity disorder

Symptoms for Gender Identity Disorder

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Drugs & Therapeutics for Gender Identity Disorder

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Drug clinical trials:

Search ClinicalTrials for Gender Identity Disorder

Search NIH Clinical Center for Gender Identity Disorder

Genetic Tests for Gender Identity Disorder

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Anatomical Context for Gender Identity Disorder

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MalaCards organs/tissues related to Gender Identity Disorder:

31
Brain, Bone

Animal Models for Gender Identity Disorder or affiliated genes

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MGI Mouse Phenotypes related to Gender Identity Disorder:

35 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.7AR, RPGRIP1L, ESR1, ESR2
2MP:00053758.6AR, ESR1, ESR2, CYP19A1
3MP:00053718.5PGR, ESR2, ESR1, RPGRIP1L
4MP:00020068.4AR, ESR1, ESR2, PGR
5MP:00053708.3CYP19A1, ESR2, ESR1, RPGRIP1L, AR
6MP:00053808.1PGR, ESR1, RPGRIP1L, AR
7MP:00036318.1CYP19A1, ESR2, ESR1, RPGRIP1L, AR
8MP:00053788.0AR, RPGRIP1L, ESR1, ESR2, CYP19A1
9MP:00053697.8CYP19A1, PGR, ESR2, ESR1, AR
10MP:00053897.8CYP19A1, PGR, ESR2, ESR1, AR
11MP:00028737.8CYP19A1, PGR, ESR2, AR
12MP:00053977.8CYP19A1, PGR, ESR2, ESR1, AR
13MP:00107687.7AR, RPGRIP1L, ESR1, ESR2, PGR
14MP:00053867.7CYP19A1, PGR, ESR2, ESR1, AR
15MP:00053877.7CYP19A1, PGR, ESR2, ESR1, AR
16MP:00053767.5CYP19A1, PGR, ESR2, ESR1, AR
17MP:00053797.5AR, RPGRIP1L, ESR1, ESR2, PGR, CYP19A1
18MP:00053907.5CYP19A1, PGR, ESR2, ESR1, RPGRIP1L, AR
19MP:00107717.5CYP19A1, PGR, ESR2, ESR1, RPGRIP1L, AR
20MP:00053857.4CYP19A1, PGR, ESR2, ESR1, RPGRIP1L, AR
21MP:00053847.4CYP19A1, PGR, ESR2, ESR1, RPGRIP1L, AR

Publications for Gender Identity Disorder

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Articles related to Gender Identity Disorder:

(show top 50)    (show all 171)
idTitleAuthorsYear
1
Long-Term Follow-Up of Adults with Gender Identity Disorder. (25690443)
2015
2
The frequency of personality disorders in patients with gender identity disorder. (25664291)
2014
3
Differences in personality traits between male-to-female and female-to-male gender identity disorder subjects. (25130781)
2014
4
Gender identity disorder and schizophrenia: neurodevelopmental disorders with common causal mechanisms? (25548672)
2014
5
Testosterone replacement elevates the serum uric acid levels in patients with female to male gender identity disorder. (24047564)
2013
6
Serum concentrations of brain-derived neurotrophic factor in patients with gender identity disorder. (23702250)
2013
7
Gender identity disorder and eating disorders: similarities and differences in terms of body uneasiness. (23347389)
2013
8
Hormone treatment of gender identity disorder in a cohort of children and adolescents. Comment. (22938118)
2012
9
Hormone treatment of gender identity disorder in a cohort of children and adolescents. Comment. (22938117)
2012
10
Report of the American Psychiatric Association Task Force on Treatment of Gender Identity Disorder. (22736225)
2012
11
Social dichotomy versus gender dichotomy: a case report of gender identity disorder. (23162201)
2012
12
Gender identity disorder in twins: a review of the case report literature. (22146048)
2012
13
Editorial Comment to Status of sex reassignment surgery for gender identity disorder in Japan. (22416672)
2012
14
Puberty suppression in gender identity disorder: the Amsterdam experience. (21587245)
2011
15
Where Christ did not go: men, women and Frusculicchi. Gender identity disorder (GID): epistemological and ethical issues relating to the psychiatric diagnosis. (22397088)
2011
16
Dysfunctional core beliefs, perceived parenting behavior and psychopathology in gender identity disorder: A comparison of male-to-female, female-to-male transsexual and nontranssexual control subjects. (21074005)
2011
17
Assessing the utility of diagnostic criteria: a multisite study on gender identity disorder. (20946149)
2011
18
Childhood maltreatment in subjects with male-to-female gender identity disorder. (21833007)
2011
19
Regional cerebral blood flow changes in female to male gender identity disorder. (20132527)
2010
20
Proposed revisions to gender identity disorder diagnoses in the DSM-5. (20725853)
2010
21
Schizophrenia modifying the expression of gender identity disorder. (18069992)
2009
22
Gender identity disorder in children and adolescents. (19380105)
2009
23
When attachment disorder presents with symptoms of gender identity disorder: case discussion. (19495434)
2009
24
Empathy in boys with gender identity disorder: a comparison to externalizing clinical control boys and community control boys and girls. (17620006)
2008
25
On the "natural history" of gender identity disorder in children. (19034186)
2008
26
What can the Samoan "Fa'afafine" teach us about the Western concept of gender identity disorder in childhood? (17951883)
2007
27
Psychiatric comorbidity among children with gender identity disorder. (17885572)
2007
28
Gender identity disorder and its medico-legal considerations. (17345887)
2007
29
Gender identity disorder. Is this a potentially fatal condition? (18693618)
2007
30
Gender identity disorder. (16892921)
2006
31
Nursing experience of redesigning a schedule to consider gender identity disorder in recruits' physical examination. (17102318)
2006
32
Donor-site morbidity of the radial forearm free flap after 125 phalloplasties in gender identity disorder. (17016186)
2006
33
Gender identity disorder: general overview and surgical treatment for vaginoplasty in male-to-female transsexuals. (16267416)
2005
34
Cross-sex hormone treatment does not change sex-sensitive cognitive performance in gender identity disorder patients. (16297984)
2005
35
Adoption in boys with gender identity disorder. (12921464)
2003
36
Demographic characteristics, social competence, and behavior problems in children with gender identity disorder: a cross-national, cross-clinic comparative analysis. (12597698)
2003
37
Gender identity disorder presenting in a girl with Asperger's disorder and obsessive compulsive disorder. (12971211)
2003
38
Psychopathology in the parents of boys with gender identity disorder. (12500069)
2003
39
The heritability of gender identity disorder in a child and adolescent twin sample. (12211624)
2002
40
Handedness in boys with gender identity disorder. (11583249)
2001
41
Gender identity disorder in DSM? (11314563)
2001
42
Gender identity disorder. (10361778)
1999
43
Secondary gender identity disorder - a case report. (21455399)
1999
44
Effects of physical appearance on masculine trait ratings of boys and girls with gender identity disorder. (9604115)
1998
45
Gender identity disorder and HIV disease. (8031915)
1994
46
The concept of gender identity disorder in childhood and adolescence after 39 years. (7996589)
1994
47
Intersexuality and the diagnosis of gender identity disorder. (8135650)
1994
48
The psychoanalytic treatment of a preschool boy with a gender identity disorder. (2026849)
1991
49
The association of gender identity disorder with parental separation. (2623124)
1989
50
Gender identity disorder of childhood. Introduction. (4067136)
1985

Variations for Gender Identity Disorder

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Expression for genes affiliated with Gender Identity Disorder

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Search GEO for disease gene expression data for Gender Identity Disorder.

Pathways for genes affiliated with Gender Identity Disorder

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Pathways related to Gender Identity Disorder according to GeneCards Suite gene sharing:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5ESR2, ESR1
2
Show member pathways
9.5ESR1, ESR2
3
Show member pathways
Development Ligand independent activation of ESR1 and ESR258
9.5ESR1, ESR2
49.5ESR1, ESR2
59.5ESR1, ESR2
6
Show member pathways
FOXA transcription factor networks36
9.4ESR1, AR
79.4ESR1, AR
89.3AR, CYP19A1
9
Show member pathways
Cell cycle ESR1 regulation of G1 S transition58
Immune response MIF JAB1 signaling58
Cell cycle Cell cycle generic schema 58
9.1ESR1, PGR
10
Show member pathways
9.1ESR1, PGR
119.0ESR2, ESR1, AR
129.0ESR2, ESR1, AR
13
Show member pathways
8.9ESR1, ESR2, CYP19A1
148.8AR, ESR1, CYP19A1
158.6ESR2, PGR, CYP19A1
16
Show member pathways
Nuclear Receptors36
8.2PGR, ESR2, ESR1, AR
17
Show member pathways
8.2PGR, ESR2, ESR1, AR

Compounds for genes affiliated with Gender Identity Disorder

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Compounds related to Gender Identity Disorder according to GeneCards Suite gene sharing:

(show top 50)    (show all 145)
idCompoundScoreTop Affiliating Genes
14-tert-octylphenol439.4ESR2, ESR1, AR
2estramustine43 1210.2ESR1, ESR2, AR
3vinclozolin439.2CYP19A1, AR, ESR1
4aminoglutethimide43 1210.1ESR1, AR, CYP19A1
5trilostane43 1210.0ESR2, PGR, ESR1
6naringenin43 129.9ESR1, CYP19A1, ESR2
7norgestimate43 129.9AR, ESR1, PGR
8idoxifene438.9ESR1, PGR, CYP19A1
9goserelin43 28 1210.8PGR, CYP19A1, ESR1
105alpha-androstane-3alpha,17beta-diol438.8AR, CYP19A1, ESR2, ESR1
11megestrol acetate438.7ESR1, PGR, CYP19A1
12bicalutamide43 59 1210.7ESR2, CYP19A1, AR, ESR1
13cyproteroneacetate438.5PGR, AR, CYP19A1
14estradiol benzoate438.5PGR, CYP19A1, ESR2, ESR1
15leuprolide acetate438.5ESR1, CYP19A1, PGR, ESR2
16anastrozole43 49 1210.5CYP19A1, PGR, ESR2, ESR1
17toremifene43 129.5ESR2, PGR, ESR1, CYP19A1
18clomiphene citrate438.4ESR1, CYP19A1, PGR, ESR2
193beta-hydroxysteroid438.4CYP19A1, PGR, ESR2, AR
20raloxifene43 49 28 1211.4ESR1, PGR, CYP19A1, ESR2
21resveratrol43 59 24 1211.4ESR1, AR, ESR2, PGR
22lapatinib43 49 1210.4AR, ESR1, PGR, CYP19A1
23danazol43 24 1210.4PGR, ESR1, CYP19A1, AR
244-hydroxytamoxifen438.4ESR1, ESR2, PGR, CYP19A1
25flutamide43 59 1210.4PGR, ESR1, CYP19A1, AR
26tibolone438.2ESR1, CYP19A1, PGR
27docetaxel43 49 59 1211.2AR, PGR, ESR1, CYP19A1
285-aza-2deoxycytidine438.1ESR2, PGR, ESR1, AR
29nandrolone43 249.0AR, ESR1, ESR2, PGR, CYP19A1
30exemestane43 49 59 1211.0ESR1, AR, PGR, CYP19A1, ESR2
31bisphenol a438.0AR, CYP19A1, ESR1, ESR2, PGR
32fulvestrant43 49 28 1211.0CYP19A1, PGR, ESR2, ESR1, AR
33letrozole43 49 59 1211.0PGR, ESR2, ESR1, AR, CYP19A1
34levonorgestrel43 59 28 1211.0PGR, CYP19A1, AR, ESR1, ESR2
35steroidal438.0AR, ESR1, CYP19A1, PGR, ESR2
36diethylstilbestrol43 28 1210.0CYP19A1, PGR, ESR2, ESR1, AR
3717beta-hydroxysteroid438.0CYP19A1, PGR, ESR2, ESR1, AR
38progestins438.0CYP19A1, PGR, ESR1, AR, ESR2
39progestin438.0CYP19A1, AR, ESR1, ESR2, PGR
40mifepristone43 28 59 1210.9PGR, ESR2, AR, ESR1, CYP19A1
41estrone43 28 24 1210.9ESR1, AR, CYP19A1, PGR, ESR2
42dihydrotestosterone43 28 24 1210.9ESR1, AR, PGR, ESR2, CYP19A1
43gnrh437.9ESR1, CYP19A1, AR, ESR2, PGR
44tamoxifen43 49 28 1210.9PGR, ESR1, AR, ESR2, CYP19A1
45doxorubicin43 49 129.8PGR, AR, CYP19A1, ESR2, ESR1
46estradiol43 24 129.8ESR2, AR, PGR, CYP19A1, ESR1
47genistein43 28 59 2 24 1212.8CYP19A1, PGR, ESR2, AR, ESR1
48cycloheximide437.7PGR, CYP19A1, ESR1, AR, ESR2
49progesterone43 28 59 24 1211.6ESR2, PGR, CYP19A1, AR, ESR1
50testosterone43 59 24 1210.5AR, ESR1, ESR2, PGR, CYP19A1

GO Terms for genes affiliated with Gender Identity Disorder

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Cellular components related to Gender Identity Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:00056548.2AR, ESR1, ESR2, PGR

Biological processes related to Gender Identity Disorder according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1uterus developmentGO:00600659.7ESR1, ESR2
2vagina developmentGO:00600689.6ESR1, ESR2
3intracellular estrogen receptor signaling pathwayGO:00305209.6ESR1, ESR2
4positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.5ESR1, ESR2
5androgen metabolic processGO:00082099.4CYP19A1, ESR1
6negative regulation of gene expressionGO:00106298.8ESR1, PGR
7cell-cell signalingGO:00072678.7AR, ESR2, PGR
8transcription initiation from RNA polymerase II promoterGO:00063678.4AR, ESR1, ESR2, PGR
9gene expressionGO:00104678.3PGR, ESR2, ESR1, AR
10signal transductionGO:00071658.1PGR, ESR2, ESR1, AR

Molecular functions related to Gender Identity Disorder according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1estrogen response element bindingGO:00340569.6ESR1, ESR2
2estrogen receptor activityGO:00302849.5ESR1, ESR2
3beta-catenin bindingGO:00080139.4AR, ESR1
4core promoter sequence-specific DNA bindingGO:00010469.4ESR2, ESR1
5steroid bindingGO:00054968.9ESR1, ESR2, PGR
6ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:00048798.9PGR, ESR2, AR
7steroid hormone receptor activityGO:00037078.8PGR, ESR2, ESR1
8enzyme bindingGO:00198998.3AR, ESR1, ESR2, PGR
9zinc ion bindingGO:00082707.9AR, ESR1, ESR2, PGR

Products for genes affiliated with Gender Identity Disorder

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Sources for Gender Identity Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet