MCID: GND002
MIFTS: 46

Gender Identity Disorder

Categories: Mental diseases

Aliases & Classifications for Gender Identity Disorder

MalaCards integrated aliases for Gender Identity Disorder:

Name: Gender Identity Disorder 12 14
Psychosexual Identity Disorder 69

Classifications:



External Ids:

Disease Ontology 12 DOID:1234
ICD10 32 F64.2 F64
SNOMED-CT 64 5095008

Summaries for Gender Identity Disorder

Disease Ontology : 12 A disease of mental health that involves a conflict between a person's actual physical gender and the gender that person identifies himself or herself as.

MalaCards based summary : Gender Identity Disorder, also known as psychosexual identity disorder, is related to transsexualism and ego-dystonic sexual orientation. An important gene associated with Gender Identity Disorder is ESR2 (Estrogen Receptor 2), and among its related pathways/superpathways are Integrated Breast Cancer Pathway and TGF-beta Signaling Pathways. The drugs Dutasteride and Estradiol have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and eye, and related phenotypes are endocrine/exocrine gland and hematopoietic system

Related Diseases for Gender Identity Disorder

Diseases related to Gender Identity Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 145)
# Related Disease Score Top Affiliating Genes
1 transsexualism 31.0 AR CYP19A1 ESR2 RFX6 RPGRIP1L
2 ego-dystonic sexual orientation 11.0
3 transvestism 10.6
4 malignant germ cell tumor 10.3 AR ESR2
5 androgen insensitivity, partial 10.3 AR CYP19A1
6 alopecia, androgenetic, 1 10.3 AR CYP19A1
7 uterine body mixed cancer 10.3 ESR2 PGR
8 prostatic hyperplasia, benign 10.3 AR CYP19A1
9 testicular germ cell cancer 10.3 AR ESR2
10 androgenic alopecia 10.3 AR CYP19A1
11 complete androgen insensitivity syndrome 10.3 AR CYP19A1
12 benign metastasizing leiomyoma 10.3 CYP19A1 PGR
13 sex differentiation disease 10.2 AR CYP19A1
14 endometrial stromal nodule 10.2 CYP19A1 PGR
15 uterine carcinosarcoma 10.2 ESR2 PGR
16 corneal abscess 10.2 AR PGR
17 ovarian serous cystadenocarcinoma 10.2 ESR2 PGR
18 papillary hidradenoma 10.2 AR PGR
19 dental fluorosis 10.2 ESR1 ESR2
20 lobular neoplasia 10.2 ESR1 ESR2
21 pseudohermaphroditism 10.2 AR CYP19A1
22 serous cystadenocarcinoma 10.2 ESR2 PGR
23 prostate disease 10.2 AR CYP19A1
24 endometrial disease 10.1 CYP19A1 ESR1
25 estrogen resistance 10.1 CYP19A1 ESR1
26 aromatase deficiency 10.1 CYP19A1 ESR1
27 transsexuality 10.1
28 vulvar syringoma 10.1 ESR1 PGR
29 vestibular gland benign neoplasm 10.1 ESR1 PGR
30 lung leiomyoma 10.1 ESR1 PGR
31 bartholin's gland adenoma 10.1 ESR1 PGR
32 glassy cell carcinoma of the cervix 10.1 ESR1 PGR
33 vulvar benign neoplasm 10.1 ESR1 PGR
34 trigonitis 10.1 ESR1 PGR
35 vulvar leiomyoma 10.1 ESR1 PGR
36 predominantly cortical thymoma 10.1 ESR1 PGR
37 breast medullary carcinoma 10.1 ESR1 PGR
38 breast scirrhous carcinoma 10.1 ESR1 PGR
39 cribriform carcinoma 10.1 ESR1 PGR
40 pelvic organ prolapse 10.1 ESR1 ESR2
41 bartholin's gland benign neoplasm 10.1 ESR1 PGR
42 gastric signet ring cell adenocarcinoma 10.1 ESR1 PGR
43 endometrial mucinous adenocarcinoma 10.1 ESR1 PGR
44 adenoid basal cell carcinoma 10.1 ESR1 PGR
45 deep angioma 10.1 ESR1 PGR
46 cervical carcinosarcoma 10.1 ESR1 PGR
47 leydig cell tumor 10.1 CYP19A1 ESR1
48 synchronous bilateral breast carcinoma 10.1 ESR1 PGR
49 intramuscular hemangioma 10.1 ESR1 PGR
50 glycogen-rich clear cell breast carcinoma 10.1 ESR1 PGR

Graphical network of the top 20 diseases related to Gender Identity Disorder:



Diseases related to Gender Identity Disorder

Symptoms & Phenotypes for Gender Identity Disorder

MGI Mouse Phenotypes related to Gender Identity Disorder:

43 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.08 CYP19A1 ESR2 AR ESR1 PGR RFX6
2 hematopoietic system MP:0005397 10.05 CYP19A1 ESR2 AR ESR1 PGR RFX6
3 behavior/neurological MP:0005386 10.04 AR ESR1 CYP19A1 PGR RFX6 ESR2
4 homeostasis/metabolism MP:0005376 10.04 ESR1 CYP19A1 AR RPGRIP1L PGR RFX6
5 cardiovascular system MP:0005385 10.03 AR ESR1 CYP19A1 RPGRIP1L PGR ESR2
6 digestive/alimentary MP:0005381 10.02 CYP19A1 ESR2 AR ESR1 RFX6 RPGRIP1L
7 immune system MP:0005387 10.02 CYP19A1 AR ESR1 PGR ESR2 RFX6
8 growth/size/body region MP:0005378 10 AR ESR1 CYP19A1 ESR2 RPGRIP1L RFX6
9 adipose tissue MP:0005375 9.97 CYP19A1 AR ESR1 ESR2 RPGRIP1L
10 integument MP:0010771 9.85 AR ESR1 CYP19A1 PGR ESR2
11 muscle MP:0005369 9.85 CYP19A1 ESR2 AR ESR1 PGR RPGRIP1L
12 limbs/digits/tail MP:0005371 9.83 AR ESR1 PGR ESR2 RPGRIP1L
13 liver/biliary system MP:0005370 9.8 ESR1 CYP19A1 AR RPGRIP1L ESR2
14 normal MP:0002873 9.65 AR ESR1 CYP19A1 PGR ESR2
15 neoplasm MP:0002006 9.62 AR ESR1 PGR ESR2
16 renal/urinary system MP:0005367 9.55 ESR1 CYP19A1 AR RPGRIP1L ESR2
17 reproductive system MP:0005389 9.43 ESR1 CYP19A1 AR RPGRIP1L PGR ESR2
18 skeleton MP:0005390 9.1 ESR1 CYP19A1 AR RPGRIP1L PGR ESR2

Drugs & Therapeutics for Gender Identity Disorder

Drugs for Gender Identity Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dutasteride Approved, Investigational Phase 3 164656-23-9 6918296 152945
2
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
3
Letrozole Approved, Investigational Phase 3 112809-51-5 3902
4
Methyltestosterone Approved Phase 3 58-18-4 6010
5
Testosterone Approved, Investigational Phase 3 58-22-0 6013
6 5-alpha Reductase Inhibitors Phase 3
7 Anabolic Agents Phase 3
8 Androgens Phase 3
9 Antineoplastic Agents, Hormonal Phase 3
10 Aromatase Inhibitors Phase 3
11
Dihydrotestosterone Phase 3 521-18-6 10635
12 Estradiol 17 beta-cypionate Phase 3
13 Estradiol 3-benzoate Phase 3
14 Estradiol valerate Phase 3 979-32-8
15 Estrogen Antagonists Phase 3
16 Estrogens Phase 3
17 Hormone Antagonists Phase 3
18 Hormones Phase 3
19 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
20 Polyestradiol phosphate Phase 3
21 Steroid Synthesis Inhibitors Phase 3
22 Testosterone 17 beta-cypionate Phase 3
23
Testosterone enanthate Phase 3 315-37-7 9416
24 Testosterone undecanoate Phase 3
25
Cyproterone Acetate Approved, Investigational 427-51-0
26
Desogestrel Approved 54024-22-5 40973
27 Lynestrenol Approved, Investigational 52-76-6
28
Hydrocortisone Approved, Vet_approved 50-23-7 657311 5754
29
Cyproterone 2098-66-0 5284537
30 Cortisol succinate
31 Hydrocortisone 17-butyrate 21-propionate
32 Hydrocortisone acetate

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Testosterone and Its Metabolites in GID Completed NCT00146146 Phase 3 testosterone undecanoate alone;testosterone undecanoate plus letrozole;testosterone undecanoate plus dutasteride
2 Effects of Sex Steroid Hormones on Human Brain Function, Structure and Connectivity Completed NCT01292785 Hormones
3 Observational Study on Metabolism and Psychopathology in Transsexual Patients Recruiting NCT02185274
4 Transgender Post-reassignment Urogynecologic Measures and Perceptions Not yet recruiting NCT03293771

Search NIH Clinical Center for Gender Identity Disorder

Genetic Tests for Gender Identity Disorder

Anatomical Context for Gender Identity Disorder

MalaCards organs/tissues related to Gender Identity Disorder:

38
Brain, Bone, Eye

Publications for Gender Identity Disorder

Articles related to Gender Identity Disorder:

(show top 50) (show all 179)
# Title Authors Year
1
The Pattern of Sexual Interest of Female-to-Male Transsexual Persons With Gender Identity Disorder Does Not Resemble That of Biological Men: An Eye-Tracking Study. ( 28823313 )
2017
2
Behavior Problems and Psychiatric Diagnoses in Girls with Gender Identity Disorder: A Follow-Up Study. ( 28594603 )
2017
3
Genetic and Environmental Influences on Traits of Gender Identity Disorder: A Study of Japanese Twins Across Developmental Stages. ( 27507021 )
2016
4
Minnesota Multiphasic Personality Inventory-2 Profiles of Patients with Gender Identity Disorder Requesting Sex Reassignment Surgery. ( 27833228 )
2016
5
Eleven-year follow up of boy with Asperger's syndrome and comorbid gender identity disorder of childhood. ( 26126993 )
2015
6
Long-Term Follow-Up of Adults with Gender Identity Disorder. ( 25690443 )
2015
7
Gender typicality in children's speech: A comparison of boys with and without gender identity disorder. ( 25920850 )
2015
8
Comparison of Masculine and Feminine Gender Roles in Iranian Patients with Gender Identity Disorder. ( 26797060 )
2015
9
The frequency of personality disorders in patients with gender identity disorder. ( 25664291 )
2014
10
Substance abuse as a way of life in marginalized gender identity disorder: A case report with review of Indian literature. ( 25311662 )
2014
11
Differences in personality traits between male-to-female and female-to-male gender identity disorder subjects. ( 25130781 )
2014
12
Gender identity disorder and schizophrenia: neurodevelopmental disorders with common causal mechanisms? ( 25548672 )
2014
13
Management challenges in a case of gender identity disorder. ( 25788806 )
2014
14
Gender identity disorder and autism spectrum disorder in a 23-year-old female. ( 23835847 )
2014
15
Effects of different steps in gender reassignment therapy on psychopathology: a prospective study of persons with a gender identity disorder. ( 24344788 )
2014
16
Click-evoked otoacoustic emissions in children and adolescents with gender identity disorder. ( 24567168 )
2014
17
Personality disorders in persons with gender identity disorder. ( 24959629 )
2014
18
Hormonal treatment reduces psychobiological distress in gender identity disorder, independently of the attachment style. ( 23574768 )
2013
19
Gender identity disorder and eating disorders: similarities and differences in terms of body uneasiness. ( 23347389 )
2013
20
Current management of gender identity disorder in childhood and adolescence: guidelines, barriers and areas of controversy. ( 23221495 )
2013
21
Parent-child relationships in gender identity disorder. ( 23959770 )
2013
22
Serum concentrations of brain-derived neurotrophic factor in patients with gender identity disorder. ( 23702250 )
2013
23
Lay theories of gender identity disorder. ( 24059967 )
2013
24
Memo outlining evidence for change for gender identity disorder in the DSM-5. ( 23868018 )
2013
25
Testosterone replacement elevates the serum uric acid levels in patients with female to male gender identity disorder. ( 24047564 )
2013
26
Sociodemographic and clinical features of gender identity disorder: an Italian multicentric evaluation. ( 23171237 )
2013
27
Risk factors for the development of well leg compartment syndrome after sex reassignment surgery in patients with gender identity disorder. ( 24286463 )
2013
28
Prevalence of gender identity disorder and suicide risk among transgender veterans utilizing veterans health administration care. ( 23947310 )
2013
29
Dose-response analysis of testosterone replacement therapy in patients with female to male gender identity disorder. ( 23117148 )
2013
30
Editorial Comment to Risk factors for the development of well leg compartment syndrome after sex reassignment surgery in patients with gender identity disorder. ( 24341964 )
2013
31
A developmental, biopsychosocial model for the treatment of children with gender identity disorder. ( 22455326 )
2012
32
Pediatrics: evaluation and management of gender identity disorder--an American tale. ( 22410681 )
2012
33
Hormone treatment of gender identity disorder in a cohort of children and adolescents. ( 22621149 )
2012
34
Sexual medicine: Can pelvic measurements predict gender identity disorder? ( 22868994 )
2012
35
First Transsexualism European Meeting : Psychological, Medical and Surgical management in gender identity disorder. An international highlight 17 (th) -18 (th) May 2012 Dental School, Turin, Italy. ( 27517686 )
2012
36
Leave to intervene in cases of gender identity disorder; normative causation; financial harms and involuntary treatment; and the right to be protected from suicide. ( 23180326 )
2012
37
Disordered eating and gender identity disorder: a qualitative study. ( 22703571 )
2012
38
Gender identity disorder in twins: a review of the case report literature. ( 22146048 )
2012
39
Editorial Comment to Status of sex reassignment surgery for gender identity disorder in Japan. ( 22416672 )
2012
40
School refusal by patients with gender identity disorder. ( 22227029 )
2012
41
Children and adolescents with gender identity disorder referred to a pediatric medical center. ( 22351896 )
2012
42
Treatment of gender identity disorder. ( 22854940 )
2012
43
From gender identity disorder to gender identity creativity: true gender self child therapy. ( 22455324 )
2012
44
Gender identity disorder: an emerging problem for pediatricians. ( 22351880 )
2012
45
Sliding Doors: should treatment of gender identity disorder and other body modifications be privately funded? ( 21132536 )
2012
46
Hormone treatment of gender identity disorder in a cohort of children and adolescents. Comment. ( 22938117 )
2012
47
Report of the American Psychiatric Association Task Force on Treatment of Gender Identity Disorder. ( 22736225 )
2012
48
Social dichotomy versus gender dichotomy: a case report of gender identity disorder. ( 23162201 )
2012
49
Demographics, behavior problems, and psychosexual characteristics of adolescents with gender identity disorder or transvestic fetishism. ( 22390530 )
2012
50
Hormone treatment of gender identity disorder in a cohort of children and adolescents. Comment. ( 22938118 )
2012

Variations for Gender Identity Disorder

Expression for Gender Identity Disorder

Search GEO for disease gene expression data for Gender Identity Disorder.

Pathways for Gender Identity Disorder

GO Terms for Gender Identity Disorder

Biological processes related to Gender Identity Disorder according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.83 AR ESR1 PGR RFX6
2 positive regulation of transcription, DNA-templated GO:0045893 9.73 AR ESR1 ESR2 RFX6
3 cell-cell signaling GO:0007267 9.69 AR ESR2 PGR
4 intracellular receptor signaling pathway GO:0030522 9.49 AR ESR1
5 mammary gland development GO:0030879 9.48 CYP19A1 PGR
6 intracellular estrogen receptor signaling pathway GO:0030520 9.46 ESR1 ESR2
7 mammary gland alveolus development GO:0060749 9.4 AR ESR1
8 androgen metabolic process GO:0008209 9.37 CYP19A1 ESR1
9 uterus development GO:0060065 9.32 CYP19A1 ESR1
10 prostate gland growth GO:0060736 9.26 AR CYP19A1
11 transcription initiation from RNA polymerase II promoter GO:0006367 9.26 AR ESR1 ESR2 PGR
12 tertiary branching involved in mammary gland duct morphogenesis GO:0060748 9.16 AR PGR
13 steroid hormone mediated signaling pathway GO:0043401 8.92 AR ESR1 ESR2 PGR

Molecular functions related to Gender Identity Disorder according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.96 AR ESR1 ESR2 PGR RFX6
2 DNA binding transcription factor activity GO:0003700 9.85 AR ESR1 ESR2 PGR
3 zinc ion binding GO:0008270 9.81 AR ESR1 ESR2 PGR
4 sequence-specific DNA binding GO:0043565 9.8 AR ESR1 ESR2 PGR
5 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.78 AR ESR1 PGR RFX6
6 enzyme binding GO:0019899 9.76 AR ESR1 ESR2 PGR
7 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding GO:0001077 9.7 AR ESR1 PGR
8 lipid binding GO:0008289 9.67 AR ESR1 ESR2 PGR
9 ATPase binding GO:0051117 9.61 AR ESR1 PGR
10 core promoter sequence-specific DNA binding GO:0001046 9.54 ESR1 ESR2
11 steroid hormone receptor activity GO:0003707 9.46 AR ESR1 ESR2 PGR
12 estrogen receptor activity GO:0030284 9.4 ESR1 ESR2
13 estrogen response element binding GO:0034056 9.32 ESR1 ESR2
14 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding GO:0038052 9.26 ESR1 ESR2
15 nuclear receptor activity GO:0004879 9.26 AR ESR1 ESR2 PGR
16 steroid binding GO:0005496 8.92 AR ESR1 ESR2 PGR

Sources for Gender Identity Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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