MCID: GNR004
MIFTS: 55

Generalized Anxiety Disorder malady

Neuronal diseases category

Summaries for Generalized Anxiety Disorder

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 An anxiety disorder that is characterized by long-lasting anxiety that is not focused on any one object or situation.

MalaCards: Generalized Anxiety Disorder, also known as anxiety generalized, is related to anxiety disorder and panic disorder. An important gene associated with Generalized Anxiety Disorder is SLC6A2 (solute carrier family 6 (neurotransmitter transporter), member 2), and among its related pathways are Citalopram Pathway, Pharmacokinetics and Regulation of thyroid hormone activity. The compounds pizotifen and ketanserin have been mentioned in the context of this disorder. Affiliated tissues include cortex, amygdala and heart, and related mouse phenotypes are muscle and integument.

Wikipedia:63 Generalized anxiety disorder (GAD) is an anxiety disorder that is characterized by excessive,... more...

Aliases & Classifications for Generalized Anxiety Disorder

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

generalized anxiety disorder 8 10 44 60
anxiety generalized 44


External Ids:

Disease Ontology8 DOID:14320
ICD9CM27 300.02
ICD1025 F41.1

Related Diseases for Generalized Anxiety Disorder

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Generalized Anxiety Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 112)
idRelated DiseaseScoreTop Affiliating Genes
1anxiety disorder32.1HTR3A, MAOA, SLC6A4, TPH1
2panic disorder31.1CCKBR, HTR1A, HTR3A, SLC6A4, TSPO
3social phobia30.9COMT, HTR1A, HTR3A, MAOA, SLC6A4
4obsessive-compulsive disorder30.8COMT, HTR1A, HTR3A, HTR2A, MAOA, SLC6A4
5agoraphobia30.6CCKBR, HTR1A, USP39, MAOA, SLC6A2
6bipolar disorder30.6SLC6A4, HTR1A
7mood disorder30.5NPY, MAOA, SLC6A4, SLC6A2, TPH1, HTR2A
8dysthymic disorder30.4MAOA, HTR2A
9irritable bowel syndrome30.4TPH1, SLC6A4, HTR3A
10substance abuse30.3SLC6A4
11personality disorder30.3MAOA, SLC6A4, TPH1
12anorexia nervosa30.2HTR1A, HTR3A, HTR2A, NPY, MAOA, SLC6A4
13neuroleptic malignant syndrome30.0HTR1A
14chronic fatigue syndrome30.0HTR1A, MAOA, SLC6A4
15alcohol abuse30.0SLC6A4, COMT
16parkinson's disease30.0MAOA, HTR1A, COMT
17schizophrenia30.0HTR2A, COMT
18conduct disorder30.0SLC6A4, MAOA, COMT
19alcohol dependence30.0HTR2A, NPY, MAOA, SLC6A4
20attention deficit hyperactivity disorder30.0COMT, HTR2A, MAOA, SLC6A4, SLC6A2
21dementia30.0COMT, HTR1A, HTR3A, HTR2A, MAOA, TSPO
22eating disorder30.0COMT, HTR1A, HTR3A, HTR2A, NPY, SLC6A4
23major depressive disorder10.8
24pain disorder10.5
25sleep disorder10.5
26somatization disorder10.4
27sexual disorder10.3
28separation anxiety disorder10.3
29physical disorder10.3
30adjustment disorder10.2
31post-traumatic stress disorder10.2
32tic disorder10.2
33withdrawal disorder10.2
34neurotic disorder10.0
35atypical depressive disorder10.0
36cerebritis10.0
37trichotillomania10.0
38good syndrome10.0
39polycystic ovary syndrome10.0
40alexithymia10.0
41chronic tic disorder10.0
42adult syndrome10.0
43stiff-person syndrome10.0
44rumination disorder10.0
45asthma10.0
46meningioma10.0
47specific phobia10.0
48thyroiditis10.0
49image syndrome10.0
50blindness10.0TSPO

Graphical network of the top 20 diseases related to Generalized Anxiety Disorder:



Diseases related to generalized anxiety disorder

Clinical Features for Generalized Anxiety Disorder

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Drugs & Therapeutics for Generalized Anxiety Disorder

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Generalized Anxiety Disorder

Drug clinical trials:

Search ClinicalTrials for Generalized Anxiety Disorder

Search NIH Clinical Center for Generalized Anxiety Disorder

Search CenterWatch for Generalized Anxiety Disorder

Genetic Tests for Generalized Anxiety Disorder

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Anatomical Context for Generalized Anxiety Disorder

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32MalaCards
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MalaCards organs/tissues related to Generalized Anxiety Disorder:

32
Cortex, Amygdala, Heart, Brain, Cingulate cortex, Prefrontal cortex, Hypothalamus, Temporal lobe, Fetal brain, Monocytes, Testes, Ovary, Thyroid, Lung, Liver, Eye

Animal Models for Generalized Anxiety Disorder or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Generalized Anxiety Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053697.8PDPN, HTR2C, HTR3A, HTR2A, RGS2, SLC6A4
2MP:00107717.7CCKBR, PDPN, HTR2C, HTR3A, SLC6A4, SLC6A2
3MP:00053857.2COMT, CCKBR, PDPN, HTR1A, MAOA, RGS2
4MP:00053787.0PDPN, HTR2C, HTR3A, NPY, PLXNA2, SLC6A4
5MP:00036316.7COMT, CCKBR, HTR2C, HTR1A, HTR3A, NPY
6MP:00053766.5HTR2C, PDPN, CCKBR, COMT, HTR1A, HTR3A
7MP:00053865.4TPH1, COMT, CCKBR, PDPN, HTR2C, HTR1A

Publications for Generalized Anxiety Disorder

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50PubMed
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Articles related to Generalized Anxiety Disorder:

(show top 50)    (show all 552)
idTitleAuthorsYear
1
Randomized controlled trial of mindfulness meditation for generalized anxiety disorder: effects on anxiety and stress reactivity. (23541163)
2013
2
The risk of cancer in patients with generalized anxiety disorder: a nationwide population-based study. (23460851)
2013
3
A Multifaith Spiritually Based Intervention Versus Supportive Therapy for Generalized Anxiety Disorder: A Pilot Randomized Controlled Trial. (24114846)
2013
4
Generalized anxiety disorder, subthreshold anxiety and anxiety symptoms in primary headache. (23331287)
2013
5
Remission of generalized anxiety disorder after 6 months of open-label treatment with venlafaxine XR. (24061331)
2013
6
Mindfulness and self-compassion in generalized anxiety disorder: examining predictors of disability. (24174978)
2013
7
Kava in the treatment of generalized anxiety disorder: a double-blind, randomized, placebo-controlled study. (23635869)
2013
8
Treating generalized anxiety disorder using complementary and alternative medicine. (23981404)
2013
9
Initial design of culturally informed behavioral intervention technologies: developing an mHealth intervention for young sexual minority men with generalized anxiety disorder and major depression. (24311444)
2013
10
Association of comorbid generalized anxiety disorder and alcohol use disorder symptoms with health-related quality of life: results from the national epidemiological survey on alcohol and related conditions. (24145158)
2013
11
Childhood maltreatment is associated with larger left thalamic gray matter volume in adolescents with generalized anxiety disorder. (23951265)
2013
12
An open-label trial of duloxetine in patients with irritable bowel syndrome and comorbid generalized anxiety disorder. (23980534)
2013
13
Exacerbation of obsessive-compulsive disorder, generalized anxiety disorder, and chronic motor tics during treatment of attention-deficit/hyperactivity disorder: medication management in an older adolescent. (24138012)
2013
14
Pregabalin versus SSRIs and SNRIs in benzodiazepine-refractory outpatients with generalized anxiety disorder: a post hoc cost-effectiveness analysis in usual medical practice in Spain. (22745564)
2012
15
Longitudinal associations between perceived parent-adolescent attachment relationship quality and generalized anxiety disorder symptoms in adolescence. (22359149)
2012
16
Clinical efficacy of Manasamitra Vataka (an Ayurveda medication) on generalized anxiety disorder with comorbid generalized social phobia: a randomized controlled study. (22784349)
2012
17
Humanistic and economic burden of generalized anxiety disorder in North America and Europe. (22154706)
2012
18
Understanding the relationships between health outcomes in generalized anxiety disorder clinical trials. (20809194)
2011
19
Attenuated responses to emotional expressions in women with generalized anxiety disorder. (20716396)
2011
20
Evaluating the efficacy of endoscopic thoracic sympathectomy for generalized social anxiety disorder with blushing complaints: a comparison with sertraline and no treatment-santiago de chile 2003-2009. (22191086)
2011
21
A meta-analysis of the relation of intolerance of uncertainty to symptoms of generalized anxiety disorder, major depressive disorder, and obsessive-compulsive disorder. (21664339)
2011
22
Assessing remission in major depressive disorder and generalized anxiety disorder clinical trials with the discan metric of the Sheehan disability scale. (21102344)
2011
23
The role of values-consistent behavior in generalized anxiety disorder. (21308890)
2011
24
The relationship between perceived discrimination and Generalized Anxiety Disorder among African Americans, Afro Caribbeans, and non-Hispanic Whites. (21041059)
2011
25
Long-term effects of short-term psychodynamic psychotherapy and cognitive-behavioural therapy in generalized anxiety disorder: 12-month follow-up. (21878162)
2011
26
Evidence-based pharmacological treatment of generalized anxiety disorder. (21211105)
2011
27
Neural response to eye contact and paroxetine treatment in generalized social anxiety disorder. (22047726)
2011
28
Interpersonal subtypes and change of interpersonal problems in the treatment of patients with generalized anxiety disorder: a pilot study. (21604899)
2011
29
Attribution retraining group therapy for outpatients with major depression disorder, generalized anxiety disorder, and obsessive-compulsive disorder: a pilot study. (23554710)
2011
30
JAMA patient page. Generalized anxiety disorder. (21285432)
2011
31
Sympathetic arousal moderates self-reported physiological arousal symptoms at baseline and physiological flexibility in response to a stressor in generalized anxiety disorder. (20036309)
2010
32
Escitalopram for persistent symptoms of generalized anxiety disorder after CBT: a pilot study. (20531128)
2010
33
Balneotherapy versus paroxetine in the treatment of generalized anxiety disorder. (20178872)
2010
34
Association between abnormal psychosocial situations in childhood, generalized anxiety disorder and oppositional defiant disorder. (20815673)
2010
35
A longitudinal study of posttraumatic stress disorder, depression, and generalized anxiety disorder in Israeli civilians exposed to war trauma. (20564364)
2010
36
Understanding behavior: generalized anxiety disorder. (20180208)
2009
37
Short-term psychodynamic psychotherapy and cognitive-behavioral therapy in generalized anxiety disorder: a randomized, controlled trial. (19570931)
2009
38
Development of a patient-reported assessment to identify placebo responders in a generalized anxiety disorder trial. (19423131)
2009
39
Screening for Generalized Anxiety Disorder in inpatient psychosomatic rehabilitation: pathological worry and the impact of depressive symptoms. (19742048)
2009
40
The short- and long-term effect of duloxetine on painful physical symptoms in patients with generalized anxiety disorder: results from three clinical trials. (19643572)
2009
41
Magnitude of potentially inappropriate prescribing in Germany among older patients with generalized anxiety disorder. (19635161)
2009
42
Improvement of psychic and somatic symptoms in adult patients with generalized anxiety disorder: examination from a duloxetine, venlafaxine extended-release and placebo-controlled trial. (18485261)
2009
43
Zolpidem extended-release improves sleep and next-day symptoms in comorbid insomnia and generalized anxiety disorder. (19440075)
2009
44
Generalized anxiety disorder in a nonclinical sample of children: symptom presentation and predictors of impairment. (18815006)
2009
45
Effects of PRX-00023, a novel, selective serotonin 1A receptor agonist on measures of anxiety and depression in generalized anxiety disorder: results of a double-blind, placebo-controlled trial. (18344738)
2008
46
Major depressive disorder, obsessive-compulsive disorder, and generalized anxiety disorder: do the sexual dysfunctions differ? (18787674)
2008
47
Correlates of generalized anxiety disorder: independent of co-morbidity with depression: findings from the first Israeli National Health Interview Survey (2003-2004). (18642124)
2008
48
Results of a naturalistic longitudinal study of benzodiazepine and SSRI use in the treatment of generalized anxiety disorder and social phobia. (16094662)
2005
49
A double-blind, placebo-controlled study of a CCK-B receptor antagonist, CI-988, in patients with generalized anxiety disorder. (8748432)
1995
50
Treatment of generalized anxiety disorder and trichotillomania with buspirone. (1554051)
1992

Genetic Variations for Generalized Anxiety Disorder

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Expression for genes affiliated with Generalized Anxiety Disorder

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Generalized Anxiety Disorder

Search GEO for disease gene expression data for Generalized Anxiety Disorder.

Pathways for genes affiliated with Generalized Anxiety Disorder

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Sources:
49PharmGKB, 53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 4Cell Signaling Technology, 29KEGG
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Compounds for genes affiliated with Generalized Anxiety Disorder

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Sources:
44Novoseek, 28IUPHAR, 49PharmGKB, 11DrugBank, 24HMDB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Generalized Anxiety Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 289)
idCompoundScoreTop Affiliating Genes
1pizotifen44 2810.7HTR2A, HTR3A, HTR1A, HTR2C
2ketanserin28 4410.6HTR1A, HTR3A, HTR2A, SLC6A4
38-hydroxy-2-(di-n-propylamino)tetralin449.6HTR2A, HTR3A, SLC6A4, HTR1A
4p-chloroamphetamine449.6MAOA, SLC6A2, HTR1A, SLC6A4
5quipazine44 2810.6HTR3A, HTR2C, HTR1A, HTR2A
61-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane449.6HTR2A, HTR2C, HTR1A, HTR3A
7mdma449.6HTR1A, SLC6A4, TPH1, SLC6A2, MAOA
8carbon-11449.6HTR1A, TSPO, MAOA, SLC6A4
9sertraline44 28 49 11 2413.5MAOA, SLC6A2, SLC6A4, HTR3A, HTR1A
105-hydroxytryptophan449.5TPH1, HTR2A, SLC6A4, HTR3A, HTR1A
11ergotamine28 44 1111.5SLC6A2, HTR3A, HTR1A, HTR2A, HTR2C
12venlafaxine49 44 11 2412.4HTR3A, SLC6A2, HTR2A, HTR1A, SLC6A4
13m-chlorophenylpiperazine449.4HTR2C, HTR1A, HTR3A, HTR2A, SLC6A4
14mcpp449.4HTR2C, SLC6A4, HTR2A, HTR3A, HTR1A
15methysergide44 28 1111.4MAOA, HTR1A, HTR2A, HTR3A, HTR2C
163,4-Methylenedioxymethamphetamine119.4SLC6A2, SLC6A4, HTR2A, HTR2C
17mesulergine28 4410.4HTR2C, HTR1A, HTR2A, HTR3A
185-hydroxyindoleacetic acid44 2410.4TPH1, SLC6A2, SLC6A4, MAOA, HTR3A
19ru 2496928 4410.3HTR1A, HTR3A, HTR2A, HTR2C
20doxepin44 28 49 1112.3SLC6A4, SLC6A2, HTR1A, HTR2A, HTR2C
21MMDA119.3MAOA, SLC6A4, SLC6A2, HTR2A
22amitriptyline44 49 28 1112.3MAOA, HTR3A, HTR1A, SLC6A4, SLC6A2, HTR2A
23nefazodone44 49 1111.2HTR2C, HTR1A, SLC6A2, SLC6A4, HTR2A, HTR3A
24nmda44 2810.2TSPO, CCKBR, COMT, MAOA, HTR1A
25imipramine44 49 28 11 2413.2MAOA, HTR3A, HTR2A, HTR1A, SLC6A2, SLC6A4
26d amphetamine449.1SLC6A4, TSPO, SLC6A2, MAOA
27homovanillic acid44 2410.1SLC6A2, COMT, MAOA, TPH1, SLC6A4
28amphetamine44 1110.1TPH1, SLC6A4, MAOA, NPY, CCKBR, SLC6A2
29yohimbine44 28 2 1112.0HTR2C, HTR2A, CCKBR, NPY, HTR1A, HTR3A
30mhpg449.0COMT, NPY, MAOA, SLC6A4, SLC6A2
31mianserin28 44 1110.9HTR2C, HTR1A, HTR3A, HTR2A, MAOA, SLC6A4
32fluvoxamine44 49 1110.8HTR2A, MAOA, SLC6A4, SLC6A2, TPH1, TSPO
33risperidone28 44 49 59 11 2413.8SLC6A4, HTR2A, HTR3A, HTR1A, HTR2C, COMT
34fenfluramine28 44 1110.7HTR2A, NPY, SLC6A4, TPH1, HTR3A, HTR1A
35clomipramine44 49 1110.7TSPO, SLC6A2, SLC6A4, MAOA, HTR2A, HTR3A
36citalopram49 44 11 2411.7HTR3A, HTR1A, HTR2C, HTR2A, MAOA, SLC6A4
37methamphetamine44 49 1110.7SLC6A2, COMT, NPY, SLC6A4, TPH1, MAOA
38fluoxetine49 44 28 1111.7TPH1, SLC6A2, SLC6A4, MAOA, HTR2A, HTR3A
39haloperidol44 28 2 49 1112.7CCKBR, HTR1A, HTR3A, HTR2A, NPY, SLC6A4
40amine448.6COMT, SLC6A4, MAOA, HTR3A, HTR2C, TPH1
41gaba448.5SLC6A4, NPY, HTR3A, HTR2C, MAOA, TPH1
42acetylcholine44 49 28 11 2412.5SLC6A2, HTR3A, TSPO, TPH1, CCKBR, NPY
43paroxetine44 49 28 1111.4COMT, HTR3A, HTR1A, TPH1, SLC6A2, HTR2A
44cocaine44 119.4SLC6A2, SLC6A4, NPY, HTR2C, CCKBR, COMT
45clozapine44 28 49 1111.4COMT, HTR2C, HTR1A, HTR3A, HTR2A, SLC6A4
46maoa448.4COMT, HTR2C, HTR1A, HTR2A, MAOA, SLC6A4
47nicotine44 49 28 1111.3SLC6A2, CCKBR, SLC6A4, MAOA, COMT, TPH1
485-hydroxytryptamine447.4NPY, HTR2A, HTR3A, HTR1A, HTR2C, COMT
49norepinephrine44 11 249.4TPH1, TSPO, COMT, SLC6A2, SLC6A4, MAOA
50dopamine44 28 11 2410.2TPH1, COMT, CCKBR, TSPO, SLC6A2, SLC6A4

GO Terms for genes affiliated with Generalized Anxiety Disorder

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16Gene Ontology
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Cellular components related to Generalized Anxiety Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058876.9CCKBR, SLC6A2, SLC6A4, PLXNA2, HTR2A, HTR3A
2plasma membraneGO:0058866.2COMT, CCKBR, SLC6A4, RGS2, PLXNA2, HTR2A

Biological processes related to Generalized Anxiety Disorder according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1regulation of hormone secretionGO:04688310.2HTR2A, HTR1A
2phospholipase C-activating serotonin receptor signaling pathwayGO:00720810.1HTR2A, HTR2C
3monoamine transportGO:01584410.1SLC6A4, SLC6A2
4positive regulation of phosphatidylinositol biosynthetic processGO:01051310.0HTR2C, HTR2A
5regulation of behaviorGO:0507959.9HTR2A, HTR1A
6dopamine catabolic processGO:0424209.8COMT, MAOA
7feeding behaviorGO:0076319.7NPY, HTR2C, CCKBR
8digestionGO:0075869.7NPY, HTR3A, CCKBR
9response to painGO:0482659.6SLC6A2, COMT
10neurotransmitter catabolic processGO:0421359.6MAOA, COMT
11serotonin receptor signaling pathwayGO:0072109.6HTR2A, HTR3A, HTR1A, HTR2C
12vasoconstrictionGO:0423109.6SLC6A4, HTR1A
13neurotransmitter biosynthetic processGO:0421369.5COMT, MAOA
14response to drugGO:0424938.9COMT, HTR2C, HTR2A, SLC6A4, TSPO
15cell proliferationGO:0082838.7CCKBR, PDPN, HTR1A, NPY, TSPO
16synaptic transmissionGO:0072688.3COMT, HTR2C, HTR3A, HTR2A, NPY, MAOA

Molecular functions related to Generalized Anxiety Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1monoamine transmembrane transporter activityGO:0085049.9SLC6A2, SLC6A4
21-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine bindingGO:0718869.5HTR2A, HTR2C
3serotonin bindingGO:0513789.5HTR2C, HTR3A, HTR2A
4serotonin receptor activityGO:0049939.3HTR2A, HTR3A, HTR1A, HTR2C

Products for genes affiliated with Generalized Anxiety Disorder

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  • Antibodies
  • Proteins
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Sources for Generalized Anxiety Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet