MCID: GNR004
MIFTS: 53

Generalized Anxiety Disorder malady

Neuronal category

Summaries for Generalized Anxiety Disorder

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 An anxiety disorder that is characterized by long-lasting anxiety that is not focused on any one object or situation.

MalaCards: Generalized Anxiety Disorder, also known as anxiety generalized, is related to anxiety disorder and panic disorder. An important gene associated with Generalized Anxiety Disorder is SLC6A2 (solute carrier family 6 (neurotransmitter transporter), member 2), and among its related pathways are Citalopram Pathway, Pharmacokinetics and Regulation of thyroid hormone activity. The compounds pizotifen and ketanserin have been mentioned in the context of this disorder. Affiliated tissues include ovary, liver and brain, and related mouse phenotypes are muscle and integument.

Wikipedia:64 Generalized anxiety disorder (GAD) is an anxiety disorder that is characterized by excessive,... more...

Aliases & Classifications for Generalized Anxiety Disorder

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

generalized anxiety disorder 8 10 45 61
anxiety generalized 45


External Ids:

Disease Ontology8 DOID:14320
ICD9CM27 300.02
ICD1025 F41.1

Related Diseases for Generalized Anxiety Disorder

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Generalized Anxiety Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 110)
idRelated DiseaseScoreTop Affiliating Genes
1anxiety disorder32.1MAOA, NPY, HTR2A, HTR3A, HTR1A, HTR2C
2panic disorder31.2HTR1A, CCKBR, SLC6A4, TSPO, HTR3A
3social phobia30.9COMT, HTR1A, HTR3A, SLC6A4, MAOA
4obsessive-compulsive disorder30.8SLC6A4, SLC6A2, TSPO, TPH1, MAOA, HTR2A
5agoraphobia30.6USP39, CCKBR, SLC6A2, HTR1A, MAOA
6bipolar disorder30.6HTR1A, SLC6A4
7dysthymic disorder30.4MAOA, HTR2A
8irritable bowel syndrome30.4HTR3A, TPH1, SLC6A4
9substance abuse30.3SLC6A4
10anorexia nervosa30.3COMT, HTR2C, HTR1A, HTR3A, HTR2A, NPY
11neuroleptic malignant syndrome30.1HTR1A
12chronic fatigue syndrome30.1SLC6A4, HTR1A, MAOA
13alcohol abuse30.1COMT, SLC6A4
14parkinson's disease30.1MAOA, HTR1A, COMT
15conduct disorder30.1COMT, MAOA, SLC6A4
16alcohol dependence30.1HTR2A, NPY, MAOA, SLC6A4
17attention deficit hyperactivity disorder30.1SLC6A4, SLC6A2, HTR2A, COMT, MAOA
18major depressive disorder10.8
19pain disorder10.5
20sleep disorder10.5
21insomnia10.4
22coronary heart disease10.4
23neurotic disorder10.2
24adjustment disorder10.2
25separation anxiety disorder10.2
26post-traumatic stress disorder10.2
27tic disorder10.2
28withdrawal disorder10.2
29headache10.2
30atypical depressive disorder10.1
31trichotillomania10.1
32good syndrome10.1
33polycystic ovary syndrome10.1
34alexithymia10.1
35chronic tic disorder10.1
36adult syndrome10.1
37stiff-person syndrome10.1
38n syndrome10.1
39rumination disorder10.1
40asthma10.1
41specific phobia10.1
42blindness10.0TSPO
43neuroblastoma10.0SLC6A2
44dyspepsia10.0HTR3A
45multiple system atrophy10.0TSPO
46restless legs syndrome10.0HTR3A
47spinocerebellar ataxia type 310.0HTR1A
48cocaine dependence10.0SLC6A4
49nicotine dependence10.0SLC6A4
50amyotrophic lateral sclerosis10.0TSPO

Graphical network of the top 20 diseases related to Generalized Anxiety Disorder:



Diseases related to generalized anxiety disorder

Clinical Features for Generalized Anxiety Disorder

Drugs & Therapeutics for Generalized Anxiety Disorder

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Generalized Anxiety Disorder

Drug clinical trials:

Search ClinicalTrials for Generalized Anxiety Disorder

Search NIH Clinical Center for Generalized Anxiety Disorder

Search CenterWatch for Generalized Anxiety Disorder

Genetic Tests for Generalized Anxiety Disorder

Anatomical Context for Generalized Anxiety Disorder

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Generalized Anxiety Disorder:

33
Ovary, Liver, Brain, Lung, Cortex, Heart, Thyroid, Monocytes, Fetal brain, Prefrontal cortex, Cingulate cortex, Temporal lobe, Hypothalamus, Amygdala, Fetal liver, Fetal lung, Fetal thyroid

Animal Models for Generalized Anxiety Disorder or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Generalized Anxiety Disorder

Sources:
51PubMed
See all sources

Articles related to Generalized Anxiety Disorder:

(show top 50)    (show all 547)
idTitleAuthorsYear
1
Clinical experiences in conducting empirically supported treatments for generalized anxiety disorder. (24411110)
2014
2
Is adolescent generalized anxiety disorder a magnet for negative parental interpersonal behaviors? (23390021)
2013
3
New approaches to the pharmacological management of generalized anxiety disorder. (23282069)
2013
4
Interpersonal constraint conferred by generalized social anxiety disorder is evident on a behavioral economics task. (23231458)
2013
5
Assessing Generalized Anxiety Disorder in Elderly People Using the GAD-7 and GAD-2 Scales: Results of a Validation Study. (23768681)
2013
6
Kava in the treatment of generalized anxiety disorder: a double-blind, randomized, placebo-controlled study. (23635869)
2013
7
Treating generalized anxiety disorder using complementary and alternative medicine. (23981404)
2013
8
In the clinic. Generalized anxiety disorder. (24297210)
2013
9
Association of cortisol with neuropsychological assessment in older adults with generalized anxiety disorder. (23336532)
2013
10
Panic attacks in generalized anxiety disorder. (23274296)
2013
11
Feasibility of exercise training for the short-term treatment of generalized anxiety disorder: a randomized controlled trial. (22116310)
2012
12
Reduced dorsal anterior cingulate cortical activity during emotional regulation and top-down attentional control in generalized social phobia, generalized anxiety disorder, and comorbid generalized social phobia/generalized anxiety disorder. (22592057)
2012
13
Efficacy and tolerability of extended release quetiapine fumarate monotherapy in the acute treatment of generalized anxiety disorder: a randomized, placebo controlled and active-controlled study. (22045039)
2012
14
Longitudinal associations between perceived parent-adolescent attachment relationship quality and generalized anxiety disorder symptoms in adolescence. (22359149)
2012
15
Examining the incremental contribution of behavioral inhibition to generalized anxiety disorder relative to other Axis I disorders and cognitive-emotional vulnerabilities. (22750475)
2012
16
Clinical efficacy of Manasamitra Vataka (an Ayurveda medication) on generalized anxiety disorder with comorbid generalized social phobia: a randomized controlled study. (22784349)
2012
17
Humanistic and economic burden of generalized anxiety disorder in North America and Europe. (22154706)
2012
18
Statistical alchemy for drug treatment of generalized anxiety disorder: a commentary on the meta-analysis by Baldwin et al. [BMJ 2011;342:d1199]. (21654185)
2011
19
Extended release quetiapine fumarate (quetiapine XR) monotherapy as maintenance treatment for generalized anxiety disorder: a long-term, randomized, placebo-controlled trial. (20881846)
2011
20
Number needed to treat to harm for discontinuation due to adverse events in the treatment of bipolar depression, major depressive disorder, and generalized anxiety disorder with atypical antipsychotics. (21034695)
2011
21
Generalized anxiety disorder: clinical presentation, diagnostic features, and guidelines for clinical practice. (20973033)
2011
22
Attenuated responses to emotional expressions in women with generalized anxiety disorder. (20716396)
2011
23
Evaluating the efficacy of endoscopic thoracic sympathectomy for generalized social anxiety disorder with blushing complaints: a comparison with sertraline and no treatment-santiago de chile 2003-2009. (22191086)
2011
24
Assessing remission in major depressive disorder and generalized anxiety disorder clinical trials with the discan metric of the Sheehan disability scale. (21102344)
2011
25
Long-term effects of short-term psychodynamic psychotherapy and cognitive-behavioural therapy in generalized anxiety disorder: 12-month follow-up. (21878162)
2011
26
Different white matter abnormalities between the first-episode, treatment-naive patients with posttraumatic stress disorder and generalized anxiety disorder without comorbid conditions. (21497403)
2011
27
Neural response to eye contact and paroxetine treatment in generalized social anxiety disorder. (22047726)
2011
28
Generalized anxiety disorder and online intelligence: a phenomenological account of why worrying is unhelpful. (21539727)
2011
29
Characteristics of generalized anxiety disorder in patients with dementia. (22062223)
2011
30
Early response to psychotherapy and long-term change in worry symptoms in older adults with generalized anxiety disorder. (21427643)
2011
31
A novel theory of experiential avoidance in generalized anxiety disorder: a review and synthesis of research supporting a contrast avoidance model of worry. (21334285)
2011
32
Frequency of generalized anxiety disorder in Chinese primary care. (20675969)
2010
33
Randomized, single-blind, trial of sertraline and buspirone for treatment of elderly patients with generalized anxiety disorder. (20132529)
2010
34
Future-oriented decision-making in Generalized Anxiety Disorder is evident across different versions of the Iowa Gambling Task. (20060098)
2010
35
Line bisection performance in patients with generalized anxiety disorder and treatment-resistant depression. (20617126)
2010
36
Major depression, generalized anxiety disorder, and panic disorder in patients scheduled for knee arthroplasty. (19493643)
2010
37
Generalized anxiety disorder within the course of major depressive disorder: examining the utility of the DSM-IV hierarchy rule. (19798759)
2009
38
Generalized anxiety disorder and medical illness. (19371503)
2009
39
Improvement of psychic and somatic symptoms in adult patients with generalized anxiety disorder: examination from a duloxetine, venlafaxine extended-release and placebo-controlled trial. (18485261)
2009
40
Questionable tolerability of tiagabine in generalized anxiety disorder. (19440099)
2009
41
Systematic review and quality assessment of economic evaluations and quality-of-life studies related to generalized anxiety disorder. (19695395)
2009
42
The burden of late-life generalized anxiety disorder: effects on disability, health-related quality of life, and healthcare utilization. (19472438)
2009
43
Disrupted amygdalar subregion functional connectivity and evidence of a compensatory network in generalized anxiety disorder. (19996041)
2009
44
Anxiety in middle adulthood: effects of age and time on the 14-year course of panic disorder, social phobia and generalized anxiety disorder. (18667095)
2009
45
Gender differences in generalized anxiety disorder: results from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). (19192444)
2008
46
Acute pregabalin reversal of citalopram-induced sexual dysfunction in generalized anxiety disorder. (18480692)
2008
47
Azapirones for generalized anxiety disorder. (16856115)
2006
48
The selective GABA reuptake inhibitor tiagabine for the treatment of generalized anxiety disorder: results of a placebo-controlled study. (16420077)
2005
49
Efficacy trial of the 5-HT2 antagonist MDL 11,939 in patients with generalized anxiety disorder. (7714223)
1995
50
Treatment of generalized anxiety disorder and trichotillomania with buspirone. (1554051)
1992

Genetic Variations for Generalized Anxiety Disorder

Expression for genes affiliated with Generalized Anxiety Disorder

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Generalized Anxiety Disorder

Search GEO for disease gene expression data for Generalized Anxiety Disorder.

Pathways for genes affiliated with Generalized Anxiety Disorder

Sources:
50PharmGKB, 54Reactome, 38NCBI BioSystems Database, 12EMD Millipore, 4Cell Signaling Technology, 30KEGG
See all sources

Compounds for genes affiliated with Generalized Anxiety Disorder

Sources:
45Novoseek, 29IUPHAR, 50PharmGKB, 11DrugBank, 24HMDB, 2BitterDB, 60Tocris Bioscience
See all sources

Compounds related to Generalized Anxiety Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 289)
idCompoundScoreTop Affiliating Genes
1pizotifen45 2910.7HTR2A, HTR3A, HTR1A, HTR2C
2ketanserin29 4510.6HTR1A, HTR3A, HTR2A, SLC6A4
38-hydroxy-2-(di-n-propylamino)tetralin459.6HTR2A, HTR3A, SLC6A4, HTR1A
4p-chloroamphetamine459.6MAOA, SLC6A2, HTR1A, SLC6A4
5quipazine45 2910.6HTR3A, HTR2C, HTR1A, HTR2A
61-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane459.6HTR2A, HTR2C, HTR1A, HTR3A
7mdma459.6HTR1A, SLC6A4, TPH1, SLC6A2, MAOA
8carbon-11459.6HTR1A, TSPO, MAOA, SLC6A4
9sertraline45 29 50 11 2413.5MAOA, SLC6A2, SLC6A4, HTR3A, HTR1A
105-hydroxytryptophan459.5TPH1, HTR2A, SLC6A4, HTR3A, HTR1A
11ergotamine29 45 1111.5SLC6A2, HTR3A, HTR1A, HTR2A, HTR2C
12venlafaxine50 45 11 2412.4HTR3A, SLC6A2, HTR2A, HTR1A, SLC6A4
13m-chlorophenylpiperazine459.4HTR2C, HTR1A, HTR3A, HTR2A, SLC6A4
14mcpp459.4HTR2C, SLC6A4, HTR2A, HTR3A, HTR1A
15methysergide45 29 1111.4MAOA, HTR1A, HTR2A, HTR3A, HTR2C
163,4-Methylenedioxymethamphetamine119.4SLC6A2, SLC6A4, HTR2A, HTR2C
17mesulergine29 4510.4HTR2C, HTR1A, HTR2A, HTR3A
185-hydroxyindoleacetic acid45 2410.4TPH1, SLC6A2, SLC6A4, MAOA, HTR3A
19ru 2496929 4510.3HTR1A, HTR3A, HTR2A, HTR2C
20doxepin45 29 50 1112.3SLC6A4, SLC6A2, HTR1A, HTR2A, HTR2C
21MMDA119.3MAOA, SLC6A4, SLC6A2, HTR2A
22amitriptyline45 50 29 1112.3MAOA, HTR3A, HTR1A, SLC6A4, SLC6A2, HTR2A
23nefazodone45 50 1111.2HTR2C, HTR1A, SLC6A2, SLC6A4, HTR2A, HTR3A
24nmda45 2910.2TSPO, CCKBR, COMT, MAOA, HTR1A
25imipramine45 50 29 11 2413.2MAOA, HTR3A, HTR2A, HTR1A, SLC6A2, SLC6A4
26d amphetamine459.1SLC6A4, TSPO, SLC6A2, MAOA
27homovanillic acid45 2410.1SLC6A2, COMT, MAOA, TPH1, SLC6A4
28amphetamine45 1110.1TPH1, SLC6A4, MAOA, NPY, CCKBR, SLC6A2
29yohimbine45 29 2 1112.0HTR2C, HTR2A, CCKBR, NPY, HTR1A, HTR3A
30mhpg459.0COMT, NPY, MAOA, SLC6A4, SLC6A2
31mianserin29 45 1110.9HTR2C, HTR1A, HTR3A, HTR2A, MAOA, SLC6A4
32fluvoxamine45 50 1110.8HTR2A, MAOA, SLC6A4, SLC6A2, TPH1, TSPO
33risperidone29 45 50 60 11 2413.8SLC6A4, HTR2A, HTR3A, HTR1A, HTR2C, COMT
34fenfluramine29 45 1110.7HTR2A, NPY, SLC6A4, TPH1, HTR3A, HTR1A
35clomipramine45 50 1110.7TSPO, SLC6A2, SLC6A4, MAOA, HTR2A, HTR3A
36citalopram50 45 11 2411.7HTR3A, HTR1A, HTR2C, HTR2A, MAOA, SLC6A4
37methamphetamine45 50 1110.7SLC6A2, COMT, NPY, SLC6A4, TPH1, MAOA
38fluoxetine50 45 29 1111.7TPH1, SLC6A2, SLC6A4, MAOA, HTR2A, HTR3A
39haloperidol45 29 2 50 1112.7CCKBR, HTR1A, HTR3A, HTR2A, NPY, SLC6A4
40amine458.6COMT, SLC6A4, MAOA, HTR3A, HTR2C, TPH1
41gaba458.5SLC6A4, NPY, HTR3A, HTR2C, MAOA, TPH1
42acetylcholine45 50 29 11 2412.5SLC6A2, HTR3A, TSPO, TPH1, CCKBR, NPY
43paroxetine45 50 29 1111.4COMT, HTR3A, HTR1A, TPH1, SLC6A2, HTR2A
44cocaine45 119.4SLC6A2, SLC6A4, NPY, HTR2C, CCKBR, COMT
45clozapine45 29 50 1111.4COMT, HTR2C, HTR1A, HTR3A, HTR2A, SLC6A4
46maoa458.4COMT, HTR2C, HTR1A, HTR2A, MAOA, SLC6A4
47nicotine45 50 29 1111.3SLC6A2, CCKBR, SLC6A4, MAOA, COMT, TPH1
485-hydroxytryptamine457.4NPY, HTR2A, HTR3A, HTR1A, HTR2C, COMT
49norepinephrine45 11 249.4TPH1, TSPO, COMT, SLC6A2, SLC6A4, MAOA
50dopamine45 29 11 2410.2TPH1, COMT, CCKBR, TSPO, SLC6A2, SLC6A4

GO Terms for genes affiliated with Generalized Anxiety Disorder

Sources:
16Gene Ontology
See all sources

Cellular components related to Generalized Anxiety Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058876.9SLC6A2, CCKBR, PDPN, HTR2C, HTR1A, HTR3A
2plasma membraneGO:0058866.2CCKBR, PDPN, HTR2C, HTR1A, HTR3A, HTR2A

Biological processes related to Generalized Anxiety Disorder according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1regulation of hormone secretionGO:04688310.2HTR2A, HTR1A
2phospholipase C-activating serotonin receptor signaling pathwayGO:00720810.1HTR2A, HTR2C
3monoamine transportGO:01584410.1SLC6A4, SLC6A2
4positive regulation of phosphatidylinositol biosynthetic processGO:01051310.0HTR2C, HTR2A
5regulation of behaviorGO:0507959.9HTR2A, HTR1A
6dopamine catabolic processGO:0424209.8COMT, MAOA
7feeding behaviorGO:0076319.7NPY, HTR2C, CCKBR
8digestionGO:0075869.7NPY, HTR3A, CCKBR
9response to painGO:0482659.6SLC6A2, COMT
10neurotransmitter catabolic processGO:0421359.6MAOA, COMT
11serotonin receptor signaling pathwayGO:0072109.6HTR2A, HTR3A, HTR1A, HTR2C
12vasoconstrictionGO:0423109.6SLC6A4, HTR1A
13neurotransmitter biosynthetic processGO:0421369.5COMT, MAOA
14response to drugGO:0424938.9COMT, HTR2C, HTR2A, SLC6A4, TSPO
15cell proliferationGO:0082838.7CCKBR, PDPN, HTR1A, NPY, TSPO
16synaptic transmissionGO:0072688.3COMT, HTR2C, HTR3A, HTR2A, NPY, MAOA

Molecular functions related to Generalized Anxiety Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1monoamine transmembrane transporter activityGO:0085049.9SLC6A2, SLC6A4
21-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine bindingGO:0718869.5HTR2A, HTR2C
3serotonin bindingGO:0513789.5HTR2C, HTR3A, HTR2A
4serotonin receptor activityGO:0049939.3HTR2A, HTR3A, HTR1A, HTR2C

Products for genes affiliated with Generalized Anxiety Disorder

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Sources for Generalized Anxiety Disorder

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet