MCID: GNR004
MIFTS: 58

Generalized Anxiety Disorder malady

Mental diseases category
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Summaries for Generalized Anxiety Disorder

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Disease Ontology:8 An anxiety disorder that is characterized by long-lasting anxiety that is not focused on any one object or situation.

MalaCards based summary: Generalized Anxiety Disorder, also known as anxiety generalized, is related to panic disorder and substance abuse. An important gene associated with Generalized Anxiety Disorder is SLC6A2 (solute carrier family 6 (neurotransmitter transporter), member 2), and among its related pathways are Venlafaxine Pathway, Pharmacokinetics and Serotonin Receptor 2 and ELK-SRF/GATA4 signaling. The compounds pizotifen and mdma have been mentioned in the context of this disorder. Affiliated tissues include heart, amygdala and cortex, and related mouse phenotypes are muscle and integument.

Wikipedia:65 Generalized anxiety disorder (GAD) is a neurological anxiety disorder that is characterized by... more...

Aliases & Classifications for Generalized Anxiety Disorder

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Generalized Anxiety Disorder, Aliases & Descriptions:

Name: Generalized Anxiety Disorder 8 10 44 62
 
Anxiety Generalized 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


External Ids:

Disease Ontology8 DOID:14320
ICD9CM27 300.02
ICD1025 F41.1

Related Diseases for Generalized Anxiety Disorder

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Diseases related to Generalized Anxiety Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 93)
idRelated DiseaseScoreTop Affiliating Genes
1panic disorder31.3TSPO, CCKBR, HTR3A, SLC6A4, HTR1A
2substance abuse31.1SLC6A4
3bipolar disorder31.1SLC6A4, HTR1A
4oppositional defiant disorder31.0SLC6A2
5neuroleptic malignant syndrome31.0HTR1A
6dysthymic disorder30.9HTR2A, MAOA
7personality disorder30.8MAOA, SLC6A4, TPH1
8social phobia30.7COMT, HTR1A, SLC6A4, MAOA, HTR3A
9agoraphobia30.7CCKBR, MAOA, HTR1A, USP39, SLC6A2
10irritable bowel syndrome30.6HTR3A, SLC6A4, TPH1, CRHR1
11borderline personality disorder30.5TPH1, MAOA, SLC6A4
12chronic fatigue syndrome30.5MAOA, HTR1A, SLC6A4
13antisocial personality disorder30.5HTR2A, MAOA, SLC6A4
14schizophrenia30.3COMT, HTR2A
15asthma30.2CRHR1, TSPO, HTR2A
16anxiety disorder30.2TSPO, CCKBR, HTR2A, SLC6A2, SLC6A4, NPY
17parkinson's disease30.1COMT, MAOA, HTR1A
18attention deficit hyperactivity disorder30.1SLC6A2, SLC6A4, MAOA, COMT, HTR2A
19obsessive-compulsive disorder30.0HTR1A, HTR3A, HTR2A, TSPO, TPH1, SLC6A2
20alcohol dependence29.9NPY, CRHR1, HTR2A, MAOA, SLC6A4
21dementia29.7MAOA, HTR2A, TSPO, HTR3A, HTR1A, COMT
22eating disorder29.2SLC6A4, NPY, CRHR1, COMT, HTR1A, HTR3A
23anorexia nervosa29.0HTR1A, HTR2C, HTR3A, HTR2A, TPH1, COMT
24mood disorder28.7SLC6A2, SLC6A4, TPH1, HTR2A, HTR3A, HTR2C
25major depressive disorder10.8
26blindness10.8
27alcoholic psychosis10.5SLC6A4
28melancholia10.5MAOA
29premature ejaculation10.4HTR1A, SLC6A4
30motion sickness10.4HTR3A, HTR1A
31cyclothymic disorder10.4HTR2A, HTR2C
32endogenous depression10.4HTR1A, SLC6A4
33heart valve disease10.4HTR2A, HTR3A
34amnestic disorder10.3HTR1A, HTR3A, TSPO
35cocaine abuse10.3HTR3A, SLC6A4
36memory impairment10.3HTR2A, HTR1A, TSPO
37hepatic encephalopathy10.3TSPO, MAOA
38drug dependence10.3SLC6A4, MAOA
39pain agnosia10.3CCKBR, HTR1A, HTR3A
40central nervous system disease10.3SLC6A4, HTR2A, SLC6A2
41portal hypertension10.3MAOA, HTR2A
42prion disease10.3HTR3A, TSPO, HTR1A
43paranoid schizophrenia10.3COMT
44pulmonary hypertension10.2SLC6A4, HTR3A, TPH1
45post-traumatic stress disorder10.2
46separation anxiety disorder10.2
47headache10.2
48constipation10.2SLC6A4, HTR3A
49temporal lobe epilepsy10.2HTR1A, NPY, TSPO
50neuroendocrine tumor10.2SLC6A2, NPY, CCKBR

Graphical network of the top 20 diseases related to Generalized Anxiety Disorder:



Diseases related to generalized anxiety disorder

Symptoms for Generalized Anxiety Disorder

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Drugs & Therapeutics for Generalized Anxiety Disorder

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Drug clinical trials:

Search ClinicalTrials for Generalized Anxiety Disorder

Search NIH Clinical Center for Generalized Anxiety Disorder

Genetic Tests for Generalized Anxiety Disorder

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Anatomical Context for Generalized Anxiety Disorder

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MalaCards organs/tissues related to Generalized Anxiety Disorder:

32
Heart, Amygdala, Cortex, Brain, Prefrontal cortex, Liver, Lung, Thyroid, Ovary, Testes, Monocytes, Fetal brain, Cingulate cortex, Temporal lobe, Hypothalamus

Animal Models for Generalized Anxiety Disorder or affiliated genes

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MGI Mouse Phenotypes related to Generalized Anxiety Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.5SLC6A4, RGS2, HTR2C, HTR3A, HTR2A, TPH1
2MP:00107718.4HTR3A, HTR2C, SLC6A2, CCKBR, SLC6A4, TPH1
3MP:00053678.4RGS2, CCKBR, HTR3A, COMT, NPY
4MP:00053787.6SLC6A2, SLC6A4, NPY, TPH1, CCKBR, HTR3A
5MP:00053857.0SLC6A4, HTR1A, TPH1, COMT, CCKBR, SLC6A2
6MP:00053766.4TPH1, CCKBR, SLC6A2, SLC6A4, NPY, CRHR1
7MP:00036315.7HTR2C, HTR1A, PLXNA2, COMT, MAOA, CRHR1
8MP:00053865.2RGS2, HTR2A, HTR3A, HTR2C, HTR1A, PLXNA2

Publications for Generalized Anxiety Disorder

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Articles related to Generalized Anxiety Disorder:

(show top 50)    (show all 540)
idTitleAuthorsYear
1
Clinical experiences in conducting empirically supported treatments for generalized anxiety disorder. (24411110)
2014
2
Age-related changes in generalized anxiety disorder symptoms. (24405581)
2014
3
Is adolescent generalized anxiety disorder a magnet for negative parental interpersonal behaviors? (23390021)
2013
4
How well do randomized controlled trial data generalize to 'real-world' clinical practice settings? A comparison of two generalized anxiety disorder studies. (24290532)
2013
5
Antidepressant medication augmented with cognitive-behavioral therapy for generalized anxiety disorder in older adults. (23680817)
2013
6
Using the GAD-Q-IV to identify generalized anxiety disorder in psychiatric treatment seeking and primary care medical samples. (24334213)
2013
7
New approaches to the pharmacological management of generalized anxiety disorder. (23282069)
2013
8
Randomized controlled trial of mindfulness meditation for generalized anxiety disorder: effects on anxiety and stress reactivity. (23541163)
2013
9
Feasibility of exercise training for the short-term treatment of generalized anxiety disorder: a randomized controlled trial. (22116310)
2012
10
Pregabalin versus SSRIs and SNRIs in benzodiazepine-refractory outpatients with generalized anxiety disorder: a post hoc cost-effectiveness analysis in usual medical practice in Spain. (22745564)
2012
11
Panic-focused psychodynamic psychotherapy in a woman with panic disorder and generalized anxiety disorder. (23030215)
2012
12
Are children with "pure" generalized anxiety disorder impaired? A comparison with comorbid and healthy children. (22963176)
2012
13
Generalized anxiety disorder and the proposed associated symptoms criterion change for DSM-5 in a treatment-seeking sample of anxious youth. (22952043)
2012
14
Cognitive and Interpersonal Moderators of Daily Co-Occurrence of Anxious and Depressed Moods in Generalized Anxiety Disorder. (23162177)
2012
15
Reduced dorsal anterior cingulate cortical activity during emotional regulation and top-down attentional control in generalized social phobia, generalized anxiety disorder, and comorbid generalized social phobia/generalized anxiety disorder. (22592057)
2012
16
Variation in the catechol-O-methyltransferase (COMT) gene and treatment response to venlafaxine XR in generalized anxiety disorder. (22417933)
2012
17
Diagnostic overlap of generalized anxiety disorder and major depressive disorder in a primary care sample. (23184657)
2012
18
Dopamine up-regulates Th17 phenotype from individuals with generalized anxiety disorder. (21872345)
2011
19
Association between generalized anxiety disorder and asthma morbidity. (21715294)
2011
20
Statistical alchemy for drug treatment of generalized anxiety disorder: a commentary on the meta-analysis by Baldwin et al. [BMJ 2011;342:d1199]. (21654185)
2011
21
Treating generalized anxiety disorder with second generation antipsychotics: a systematic review and meta-analysis. (21508847)
2011
22
Comparisons of the tolerability and sensitivity of quetiapine-XR in the acute treatment of schizophrenia, bipolar mania, bipolar depression, major depressive disorder, and generalized anxiety disorder. (20875219)
2011
23
Guided internet-delivered cognitive behavior therapy for generalized anxiety disorder: a randomized controlled trial. (21770848)
2011
24
Assessment of quality of life enjoyment and satisfaction questionnaire-short form responder thresholds in generalized anxiety disorder and bipolar disorder studies. (21164351)
2011
25
Noradrenergic function in generalized anxiety disorder: impact of treatment with venlafaxine on the physiological and psychological responses to clonidine challenge. (20093317)
2011
26
Augmenting antidepressant medication with modular CBT for geriatric generalized anxiety disorder: a pilot study. (20872925)
2011
27
Intolerance of uncertainty, worry, and rumination in major depressive disorder and generalized anxiety disorder. (20439149)
2010
28
A multicenter, placebo-controlled, double-blind, randomized study of efficacy and safety of ocinaplon (DOV 273,547) in generalized anxiety disorder. (20041911)
2010
29
Failure of anterior cingulate activation and connectivity with the amygdala during implicit regulation of emotional processing in generalized anxiety disorder. (20123913)
2010
30
Management of generalized anxiety disorder in primary care: identifying the challenges and unmet needs. (20694114)
2010
31
Fetal growth and the lifetime risk of generalized anxiety disorder. (20734359)
2010
32
Diagnostic comorbidity in adults with generalized anxiety disorder: impact of comorbidity on psychotherapy outcome and impact of psychotherapy on comorbid diagnoses. (20171328)
2010
33
Comorbidity of generalized anxiety disorder and substance use disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. (20923623)
2010
34
Generalized implicit fear associations in generalized anxiety disorder. (20112248)
2010
35
Frequency of generalized anxiety disorder in Chinese primary care. (20675969)
2010
36
Understanding behavior: generalized anxiety disorder. (20180208)
2009
37
Short-term psychodynamic psychotherapy and cognitive-behavioral therapy in generalized anxiety disorder: a randomized, controlled trial. (19570931)
2009
38
Generalized anxiety disorder, major depressive disorder, and their comorbidity as predictors of all-cause and cardiovascular mortality: the Vietnam experience study. (19321850)
2009
39
Adding a motivational interviewing pretreatment to cognitive behavioral therapy for generalized anxiety disorder: a preliminary randomized controlled trial. (19665347)
2009
40
Insomnia in older adults with generalized anxiety disorder. (19472436)
2009
41
Development of a patient-reported assessment to identify placebo responders in a generalized anxiety disorder trial. (19423131)
2009
42
Generalized anxiety disorder and psychiatric comorbidities such as depression, bipolar disorder, and substance abuse. (19371501)
2009
43
Psychodynamic psychotherapy outcome for generalized anxiety disorder. (19651745)
2009
44
Startle response in generalized anxiety disorder. (19105213)
2009
45
A preliminary study of fMRI-guided rTMS in the treatment of generalized anxiety disorder. (18572984)
2008
46
Effects of PRX-00023, a novel, selective serotonin 1A receptor agonist on measures of anxiety and depression in generalized anxiety disorder: results of a double-blind, placebo-controlled trial. (18344738)
2008
47
Influence of psychiatric comorbidity on recovery and recurrence in generalized anxiety disorder, social phobia, and panic disorder: a 12-year prospective study. (15930067)
2005
48
The Nottingham Study of Neurotic Disorder: predictors of 12-year outcome of dysthymic, panic and generalized anxiety disorder. (15724870)
2004
49
A phase II multicenter dose-finding, efficacy and safety trial of ipsapirone in outpatients with generalized anxiety disorder. (7915845)
1994
50
Thyroid hormones in panic disorder, panic disorder with agoraphobia, and generalized anxiety disorder. (3379028)
1988

Variations for Generalized Anxiety Disorder

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Expression for genes affiliated with Generalized Anxiety Disorder

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Expression patterns in normal tissues for genes affiliated with Generalized Anxiety Disorder

Search GEO for disease gene expression data for Generalized Anxiety Disorder.

Pathways for genes affiliated with Generalized Anxiety Disorder

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Pathways related to Generalized Anxiety Disorder according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9SLC6A4, SLC6A2
29.8HTR2C, HTR2A
39.8NPY, SLC6A2
4
Show member pathways
Serotonin Transporter Activity37
9.6MAOA, SLC6A2, SLC6A4
5
Show member pathways
9.6HTR2A, HTR2C, HTR1A
69.6HTR2C, HTR2A, CCKBR
79.5COMT, MAOA
8
Show member pathways
9.5MAOA, COMT
99.5COMT, MAOA
109.5COMT, MAOA
11
Show member pathways
catecholamine biosynthesis37
9.3COMT, MAOA, TPH1
12
Show member pathways
9.3HTR2C, HTR3A, HTR2A, HTR1A
13
Show member pathways
9.1CCKBR, RGS2, HTR2C, HTR2A
149.0NPY, PLXNA2, HTR1A, TPH1
158.7SLC6A4, TPH1, MAOA, HTR1A, HTR3A, HTR2A
168.4HTR2A, SLC6A4, HTR1A, HTR2C, HTR3A, TPH1
17
Show member pathways
7.8HTR2A, NPY, CRHR1, HTR1A, TSPO, CCKBR
18
Show member pathways
7.7COMT, HTR1A, HTR2C, TPH1, MAOA, SLC6A4
19
Show member pathways
7.6NPY, RGS2, CRHR1, HTR1A, HTR2C, HTR2A

Compounds for genes affiliated with Generalized Anxiety Disorder

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Compounds related to Generalized Anxiety Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 298)
idCompoundScoreTop Affiliating Genes
1pizotifen28 4410.6HTR2C, HTR2A, HTR1A, HTR3A
2mdma449.5SLC6A4, MAOA, HTR1A, TPH1, SLC6A2
3quipazine44 2810.5HTR1A, HTR3A, HTR2A, HTR2C
48-hydroxy-2-(di-n-propylamino)tetralin449.4SLC6A4, HTR1A, HTR3A, HTR2A
51-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane449.4HTR1A, HTR3A, HTR2A, HTR2C
65-hydroxytryptophan449.4HTR1A, HTR3A, HTR2A, TPH1, SLC6A4
7carbon-11449.4TSPO, HTR1A, MAOA, SLC6A4
8ergotamine28 44 1111.3SLC6A2, HTR1A, HTR2C, HTR3A, HTR2A
9p-chloroamphetamine449.3SLC6A2, SLC6A4, MAOA, HTR1A
10escitalopram44 50 24 1112.3SLC6A4, HTR2C, HTR2A, SLC6A2, HTR1A
11m-chlorophenylpiperazine449.3HTR1A, HTR2A, SLC6A4, HTR3A, HTR2C
12mcpp449.3HTR2C, HTR2A, HTR3A, HTR1A, SLC6A4
13sertraline44 28 50 24 1113.3SLC6A4, SLC6A2, MAOA, HTR3A, HTR1A
14methysergide44 28 1111.3MAOA, HTR2C, HTR3A, HTR2A, HTR1A
155-hydroxyindoleacetic acid44 2410.3MAOA, TPH1, SLC6A2, SLC6A4, HTR3A
16Serotonin249.2HTR2A, HTR3A, MAOA, SLC6A4, HTR1A
17ketanserin44 2810.2SLC6A4, HTR2C, HTR3A, HTR2A, HTR1A
18amitriptyline44 28 50 1112.1HTR1A, SLC6A4, HTR2A, MAOA, SLC6A2, HTR3A
19nefazodone44 50 1111.1SLC6A2, SLC6A4, HTR1A, HTR2C, HTR3A, HTR2A
20doxepin44 28 50 1112.1HTR2C, SLC6A2, SLC6A4, HTR1A, HTR2A
21imipramine44 28 50 24 1113.1HTR1A, HTR3A, HTR2A, SLC6A4, SLC6A2, MAOA
22homovanillic acid44 2410.0SLC6A4, MAOA, SLC6A2, TPH1, COMT
23amphetamine44 50 1111.0TPH1, SLC6A2, SLC6A4, NPY, MAOA, CCKBR
24mesulergine28 4410.0HTR1A, HTR2C, HTR3A, HTR2A
25yohimbine44 2 28 1111.9NPY, HTR1A, HTR2C, HTR2A, CCKBR, HTR3A
26mhpg448.9SLC6A2, SLC6A4, NPY, COMT, MAOA
27venlafaxine44 50 24 1111.9SLC6A2, SLC6A4, COMT, HTR1A, HTR3A, HTR2A
28mianserin44 28 1110.8SLC6A2, SLC6A4, MAOA, HTR1A, HTR2C, HTR3A
29risperidone44 50 28 61 24 1113.7SLC6A4, COMT, HTR1A, HTR2C, HTR3A, HTR2A
30fenfluramine44 28 1110.7SLC6A4, NPY, HTR1A, HTR2C, HTR3A, HTR2A
31methamphetamine44 50 1110.6SLC6A2, TPH1, COMT, SLC6A4, NPY, MAOA
32citalopram44 50 24 1111.6SLC6A4, MAOA, HTR1A, HTR2C, HTR3A, HTR2A
33clomipramine44 50 1110.6TSPO, HTR2A, HTR3A, HTR2C, HTR1A, MAOA
34olanzapine44 50 28 24 1112.6HTR2A, SLC6A4, COMT, HTR1A, HTR2C, HTR3A
35haloperidol44 50 28 2 1112.6TSPO, SLC6A2, SLC6A4, NPY, HTR1A, HTR3A
36acetylcholine44 50 28 24 1112.5TPH1, TSPO, SLC6A2, NPY, HTR1A, HTR2C
37amine448.4HTR3A, TPH1, HTR2C, SLC6A2, COMT, SLC6A4
38paroxetine44 50 28 1111.3SLC6A2, SLC6A4, MAOA, COMT, HTR1A, HTR3A
39maoa448.3SLC6A2, SLC6A4, MAOA, COMT, HTR2C, HTR2A
40clozapine44 28 50 1111.2HTR2A, HTR3A, HTR2C, HTR1A, COMT, SLC6A4
41nicotine44 28 50 1111.2CCKBR, NPY, COMT, TSPO, TPH1, SLC6A2
42fluvoxamine44 50 1110.1HTR2A, TSPO, TPH1, HTR3A, HTR1A, SLC6A2
43nmda44 288.9CCKBR, NPY, SLC6A4, MAOA, COMT, TSPO
44catecholamine447.8NPY, TPH1, CRHR1, MAOA, COMT, SLC6A2
45fluoxetine44 50 28 1110.7SLC6A2, SLC6A4, CRHR1, MAOA, HTR1A, HTR2C
46gaba447.6TSPO, TPH1, MAOA, CRHR1, HTR2C, NPY
47cocaine44 118.6CCKBR, HTR2C, CRHR1, NPY, COMT, TSPO
485-hydroxytryptamine447.3SLC6A2, HTR1A, HTR2A, HTR3A, HTR2C, COMT
49norepinephrine44 24 119.2TSPO, HTR2A, HTR3A, HTR2C, HTR1A, COMT
50dopamine44 28 24 119.2SLC6A2, HTR3A, HTR2C, HTR1A, COMT, CRHR1

GO Terms for genes affiliated with Generalized Anxiety Disorder

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Cellular components related to Generalized Anxiety Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuron projectionGO:0430059.3SLC6A2, SLC6A4, RGS2, TPH1
2integral component of plasma membraneGO:0058877.0SLC6A4, CRHR1, PLXNA2, HTR1A, HTR2C, HTR3A
3plasma membraneGO:0058865.8SLC6A2, CCKBR, HTR2A, SLC6A4, RGS2, CRHR1

Biological processes related to Generalized Anxiety Disorder according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1regulation of hormone secretionGO:04688310.3HTR1A, HTR2A
2monoamine transportGO:01584410.2SLC6A4, SLC6A2
3phospholipase C-activating serotonin receptor signaling pathwayGO:00720810.2HTR2C, HTR2A
4regulation of behaviorGO:05079510.1HTR2A, HTR1A
5positive regulation of phosphatidylinositol biosynthetic processGO:01051310.1HTR2A, HTR2C
6vasoconstrictionGO:0423109.9HTR1A, SLC6A4
7dopamine catabolic processGO:0424209.8COMT, MAOA
8release of sequestered calcium ion into cytosolGO:0512099.8HTR2C, HTR2A
9neurotransmitter catabolic processGO:0421359.8MAOA, COMT
10digestionGO:0075869.7NPY, HTR3A, CCKBR
11feeding behaviorGO:0076319.7NPY, HTR2C, CCKBR
12response to painGO:0482659.7COMT, SLC6A2
13neurotransmitter biosynthetic processGO:0421369.7MAOA, COMT
14response to immobilization stressGO:0359029.7CRHR1, TPH1
15serotonin receptor signaling pathwayGO:0072109.6HTR2A, HTR3A, HTR2C, HTR1A
16behavioral fear responseGO:0016629.5HTR1A, HTR2C
17behavioral response to cocaineGO:0481489.5CRHR1, HTR2A
18behavioral response to painGO:0482669.5TSPO, CRHR1
19cell proliferationGO:0082839.5NPY, HTR1A, CCKBR, TSPO
20phospholipase C-activating G-protein coupled receptor signaling pathwayGO:0072009.3CCKBR, HTR2C, CRHR1
21memoryGO:0076139.3SLC6A4, CRHR1, HTR2A
22adrenal gland developmentGO:0303259.3CRHR1, TSPO
23response to drugGO:0424938.8TSPO, HTR2A, HTR2C, COMT, SLC6A4, SLC6A2
24synaptic transmissionGO:0072688.0SLC6A2, TSPO, HTR2A, HTR3A, HTR2C, COMT

Molecular functions related to Generalized Anxiety Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1beta-tubulin bindingGO:0484879.8SLC6A2, RGS2
21-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine bindingGO:0718869.8HTR2A, HTR2C
3monoamine transmembrane transporter activityGO:0085049.8SLC6A2, SLC6A4
4serotonin bindingGO:0513789.6HTR2C, HTR3A, HTR2A
5serotonin receptor activityGO:0049939.4HTR1A, HTR2C, HTR3A, HTR2A
6G-protein alpha-subunit bindingGO:0019659.1CRHR1, HTR2A

Products for genes affiliated with Generalized Anxiety Disorder

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Sources for Generalized Anxiety Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
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36MGI
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40NDF-RT
43NINDS
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