MCID: GNR004
MIFTS: 49

Generalized Anxiety Disorder malady

Mental diseases category

Aliases & Classifications for Generalized Anxiety Disorder

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Generalized Anxiety Disorder, Aliases & Descriptions:

Name: Generalized Anxiety Disorder 9 11 43 60
 
Anxiety Generalized 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


External Ids:

Disease Ontology9 DOID:14320
ICD9CM27 300.02
ICD1025 F41.1

Summaries for Generalized Anxiety Disorder

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Disease Ontology:9 An anxiety disorder that is characterized by long-lasting anxiety that is not focused on any one object or situation.

MalaCards based summary: Generalized Anxiety Disorder, also known as anxiety generalized, is related to panic disorder and substance abuse. An important gene associated with Generalized Anxiety Disorder is SLC6A2 (solute carrier family 6 (neurotransmitter transporter), member 2), and among its related pathways are Venlafaxine Pathway, Pharmacokinetics and Serotonin Receptor 2 and ELK-SRF/GATA4 signaling. The compounds pizotifen and mdma have been mentioned in the context of this disorder. Affiliated tissues include heart, amygdala and brain, and related mouse phenotypes are muscle and integument.

Wikipedia:63 Generalized anxiety disorder (GAD) is an anxiety disorder that is characterized by excessive,... more...

Related Diseases for Generalized Anxiety Disorder

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Diseases related to Generalized Anxiety Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 90)
idRelated DiseaseScoreTop Affiliating Genes
1panic disorder31.3TSPO, CCKBR, HTR3A, SLC6A4, HTR1A
2substance abuse31.1SLC6A4
3bipolar disorder31.1SLC6A4, HTR1A
4oppositional defiant disorder31.0SLC6A2
5neuroleptic malignant syndrome30.9HTR1A
6dysthymic disorder30.9HTR2A, MAOA
7personality disorder30.7MAOA, SLC6A4, TPH1
8social phobia30.7COMT, HTR1A, SLC6A4, MAOA, HTR3A
9agoraphobia30.7CCKBR, MAOA, HTR1A, USP39, SLC6A2
10irritable bowel syndrome30.6HTR3A, SLC6A4, TPH1, CRHR1
11borderline personality disorder30.5TPH1, MAOA, SLC6A4
12antisocial personality disorder30.5HTR2A, MAOA, SLC6A4
13chronic fatigue syndrome30.5MAOA, HTR1A, SLC6A4
14schizophrenia30.3COMT, HTR2A
15asthma30.2CRHR1, TSPO, HTR2A
16anxiety disorder30.2TSPO, CCKBR, HTR2A, SLC6A2, SLC6A4, NPY
17attention deficit-hyperactivity disorder30.1SLC6A2, SLC6A4, MAOA, COMT, HTR2A
18obsessive-compulsive disorder30.0HTR1A, HTR3A, HTR2A, TSPO, TPH1, SLC6A2
19alcohol dependence29.9NPY, CRHR1, HTR2A, MAOA, SLC6A4
20dementia29.7MAOA, HTR2A, TSPO, HTR3A, HTR1A, COMT
21neurotic disorder29.4HTR3A, HTR2A, TPH1, HTR1A, MAOA, SLC6A4
22eating disorder29.2SLC6A4, NPY, CRHR1, COMT, HTR1A, HTR3A
23anorexia nervosa29.0HTR1A, HTR2C, HTR3A, HTR2A, TPH1, COMT
24mood disorder28.7SLC6A2, SLC6A4, TPH1, HTR2A, HTR3A, HTR2C
25blindness10.8
26alcoholic psychosis10.5SLC6A4
27melancholia10.5MAOA
28premature ejaculation10.4HTR1A, SLC6A4
29motion sickness10.4HTR3A, HTR1A
30major depressive disorder and accelerated response to antidepressant drug treatment10.4HTR1A, SLC6A4
31cyclothymic disorder10.4HTR2A, HTR2C
32heart valve disease10.3HTR2A, HTR3A
33endogenous depression10.3SLC6A4, MAOA
34cocaine abuse10.3HTR3A, SLC6A4
35amnestic disorder10.3HTR1A, HTR3A, TSPO
36hepatic encephalopathy10.3TSPO, MAOA
37drug dependence10.3SLC6A4, MAOA
38pain agnosia10.3CCKBR, HTR1A, HTR3A
39central nervous system disease10.3SLC6A4, HTR2A, SLC6A2
40portal hypertension10.3MAOA, HTR2A
41prion disease10.3HTR3A, TSPO, HTR1A
42paranoid schizophrenia10.3COMT
43alexithymia10.2
44separation anxiety disorder10.2
45post-traumatic stress disorder10.2
46headache10.2
47pulmonary hypertension10.2SLC6A4, HTR3A, TPH1
48constipation10.2SLC6A4, HTR3A
49temporal lobe epilepsy10.2HTR1A, NPY, TSPO
50neuroendocrine tumor10.2SLC6A2, NPY, CCKBR

Graphical network of the top 20 diseases related to Generalized Anxiety Disorder:



Diseases related to generalized anxiety disorder

Symptoms for Generalized Anxiety Disorder

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Drugs & Therapeutics for Generalized Anxiety Disorder

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Drug clinical trials:

Search ClinicalTrials for Generalized Anxiety Disorder

Search NIH Clinical Center for Generalized Anxiety Disorder

Genetic Tests for Generalized Anxiety Disorder

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Anatomical Context for Generalized Anxiety Disorder

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MalaCards organs/tissues related to Generalized Anxiety Disorder:

31
Heart, Amygdala, Brain, Cortex, Prefrontal cortex, Liver, Lung, Thyroid, Ovary, Testes, Fetal brain, Cingulate cortex, Temporal lobe, Hypothalamus

Animal Models for Generalized Anxiety Disorder or affiliated genes

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MGI Mouse Phenotypes related to Generalized Anxiety Disorder:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.5SLC6A4, RGS2, HTR2C, HTR3A, HTR2A, TPH1
2MP:00107718.4HTR3A, HTR2C, SLC6A2, CCKBR, SLC6A4, TPH1
3MP:00053678.4RGS2, CCKBR, HTR3A, COMT, NPY
4MP:00053787.6SLC6A2, SLC6A4, NPY, TPH1, CCKBR, HTR3A
5MP:00053857.0SLC6A4, HTR1A, TPH1, COMT, CCKBR, SLC6A2
6MP:00053766.4TPH1, CCKBR, SLC6A2, SLC6A4, NPY, CRHR1
7MP:00036315.7HTR2C, HTR1A, PLXNA2, COMT, MAOA, CRHR1
8MP:00053865.2RGS2, HTR2A, HTR3A, HTR2C, HTR1A, PLXNA2

Publications for Generalized Anxiety Disorder

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Articles related to Generalized Anxiety Disorder:

(show top 50)    (show all 559)
idTitleAuthorsYear
1
Brain structural abnormalities in patients with major depression with or without generalized anxiety disorder comorbidity. (25794861)
2015
2
Clinical experiences in conducting empirically supported treatments for generalized anxiety disorder. (24411110)
2014
3
Age-related changes in generalized anxiety disorder symptoms. (24405581)
2014
4
Is adolescent generalized anxiety disorder a magnet for negative parental interpersonal behaviors? (23390021)
2013
5
How well do randomized controlled trial data generalize to 'real-world' clinical practice settings? A comparison of two generalized anxiety disorder studies. (24290532)
2013
6
Antidepressant medication augmented with cognitive-behavioral therapy for generalized anxiety disorder in older adults. (23680817)
2013
7
Using the GAD-Q-IV to identify generalized anxiety disorder in psychiatric treatment seeking and primary care medical samples. (24334213)
2013
8
New approaches to the pharmacological management of generalized anxiety disorder. (23282069)
2013
9
Randomized controlled trial of mindfulness meditation for generalized anxiety disorder: effects on anxiety and stress reactivity. (23541163)
2013
10
Feasibility of exercise training for the short-term treatment of generalized anxiety disorder: a randomized controlled trial. (22116310)
2012
11
Pregabalin versus SSRIs and SNRIs in benzodiazepine-refractory outpatients with generalized anxiety disorder: a post hoc cost-effectiveness analysis in usual medical practice in Spain. (22745564)
2012
12
Panic-focused psychodynamic psychotherapy in a woman with panic disorder and generalized anxiety disorder. (23030215)
2012
13
Are children with "pure" generalized anxiety disorder impaired? A comparison with comorbid and healthy children. (22963176)
2012
14
Generalized anxiety disorder and the proposed associated symptoms criterion change for DSM-5 in a treatment-seeking sample of anxious youth. (22952043)
2012
15
Cognitive and Interpersonal Moderators of Daily Co-Occurrence of Anxious and Depressed Moods in Generalized Anxiety Disorder. (23162177)
2012
16
Reduced dorsal anterior cingulate cortical activity during emotional regulation and top-down attentional control in generalized social phobia, generalized anxiety disorder, and comorbid generalized social phobia/generalized anxiety disorder. (22592057)
2012
17
Variation in the catechol-O-methyltransferase (COMT) gene and treatment response to venlafaxine XR in generalized anxiety disorder. (22417933)
2012
18
Diagnostic overlap of generalized anxiety disorder and major depressive disorder in a primary care sample. (23184657)
2012
19
Dopamine up-regulates Th17 phenotype from individuals with generalized anxiety disorder. (21872345)
2011
20
Association between generalized anxiety disorder and asthma morbidity. (21715294)
2011
21
Statistical alchemy for drug treatment of generalized anxiety disorder: a commentary on the meta-analysis by Baldwin et al. [BMJ 2011;342:d1199]. (21654185)
2011
22
Treating generalized anxiety disorder with second generation antipsychotics: a systematic review and meta-analysis. (21508847)
2011
23
Comparisons of the tolerability and sensitivity of quetiapine-XR in the acute treatment of schizophrenia, bipolar mania, bipolar depression, major depressive disorder, and generalized anxiety disorder. (20875219)
2011
24
Guided internet-delivered cognitive behavior therapy for generalized anxiety disorder: a randomized controlled trial. (21770848)
2011
25
Assessment of quality of life enjoyment and satisfaction questionnaire-short form responder thresholds in generalized anxiety disorder and bipolar disorder studies. (21164351)
2011
26
Noradrenergic function in generalized anxiety disorder: impact of treatment with venlafaxine on the physiological and psychological responses to clonidine challenge. (20093317)
2011
27
Augmenting antidepressant medication with modular CBT for geriatric generalized anxiety disorder: a pilot study. (20872925)
2011
28
Intolerance of uncertainty, worry, and rumination in major depressive disorder and generalized anxiety disorder. (20439149)
2010
29
A multicenter, placebo-controlled, double-blind, randomized study of efficacy and safety of ocinaplon (DOV 273,547) in generalized anxiety disorder. (20041911)
2010
30
Failure of anterior cingulate activation and connectivity with the amygdala during implicit regulation of emotional processing in generalized anxiety disorder. (20123913)
2010
31
Management of generalized anxiety disorder in primary care: identifying the challenges and unmet needs. (20694114)
2010
32
Fetal growth and the lifetime risk of generalized anxiety disorder. (20734359)
2010
33
Diagnostic comorbidity in adults with generalized anxiety disorder: impact of comorbidity on psychotherapy outcome and impact of psychotherapy on comorbid diagnoses. (20171328)
2010
34
Comorbidity of generalized anxiety disorder and substance use disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. (20923623)
2010
35
Generalized implicit fear associations in generalized anxiety disorder. (20112248)
2010
36
Understanding behavior: generalized anxiety disorder. (20180208)
2009
37
Short-term psychodynamic psychotherapy and cognitive-behavioral therapy in generalized anxiety disorder: a randomized, controlled trial. (19570931)
2009
38
Generalized anxiety disorder, major depressive disorder, and their comorbidity as predictors of all-cause and cardiovascular mortality: the Vietnam experience study. (19321850)
2009
39
Adding a motivational interviewing pretreatment to cognitive behavioral therapy for generalized anxiety disorder: a preliminary randomized controlled trial. (19665347)
2009
40
Insomnia in older adults with generalized anxiety disorder. (19472436)
2009
41
Development of a patient-reported assessment to identify placebo responders in a generalized anxiety disorder trial. (19423131)
2009
42
Generalized anxiety disorder and psychiatric comorbidities such as depression, bipolar disorder, and substance abuse. (19371501)
2009
43
Psychodynamic psychotherapy outcome for generalized anxiety disorder. (19651745)
2009
44
Startle response in generalized anxiety disorder. (19105213)
2009
45
A preliminary study of fMRI-guided rTMS in the treatment of generalized anxiety disorder. (18572984)
2008
46
Effects of PRX-00023, a novel, selective serotonin 1A receptor agonist on measures of anxiety and depression in generalized anxiety disorder: results of a double-blind, placebo-controlled trial. (18344738)
2008
47
Influence of psychiatric comorbidity on recovery and recurrence in generalized anxiety disorder, social phobia, and panic disorder: a 12-year prospective study. (15930067)
2005
48
The Nottingham Study of Neurotic Disorder: predictors of 12-year outcome of dysthymic, panic and generalized anxiety disorder. (15724870)
2004
49
A phase II multicenter dose-finding, efficacy and safety trial of ipsapirone in outpatients with generalized anxiety disorder. (7915845)
1994
50
Thyroid hormones in panic disorder, panic disorder with agoraphobia, and generalized anxiety disorder. (3379028)
1988

Variations for Generalized Anxiety Disorder

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Expression for genes affiliated with Generalized Anxiety Disorder

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Search GEO for disease gene expression data for Generalized Anxiety Disorder.

Pathways for genes affiliated with Generalized Anxiety Disorder

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Pathways related to Generalized Anxiety Disorder according to GeneCards Suite gene sharing:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9SLC6A4, SLC6A2
29.8HTR2C, HTR2A
39.8NPY, SLC6A2
4
Show member pathways
Serotonin Transporter Activity36
9.6MAOA, SLC6A2, SLC6A4
5
Show member pathways
9.6HTR2A, HTR2C, HTR1A
69.6HTR2C, HTR2A, CCKBR
79.5COMT, MAOA
8
Show member pathways
9.5MAOA, COMT
99.5COMT, MAOA
109.5COMT, MAOA
11
Show member pathways
catecholamine biosynthesis36
9.3COMT, MAOA, TPH1
12
Show member pathways
9.3HTR2C, HTR3A, HTR2A, HTR1A
13
Show member pathways
9.1CCKBR, RGS2, HTR2C, HTR2A
149.0NPY, PLXNA2, HTR1A, TPH1
158.7SLC6A4, TPH1, MAOA, HTR1A, HTR3A, HTR2A
168.4HTR2A, SLC6A4, HTR1A, HTR2C, HTR3A, TPH1
17
Show member pathways
7.8HTR2A, NPY, CRHR1, HTR1A, TSPO, CCKBR
18
Show member pathways
7.7COMT, HTR1A, HTR2C, TPH1, MAOA, SLC6A4
19
Show member pathways
7.6NPY, RGS2, CRHR1, HTR1A, HTR2C, HTR2A

Compounds for genes affiliated with Generalized Anxiety Disorder

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Compounds related to Generalized Anxiety Disorder according to GeneCards Suite gene sharing:

(show top 50)    (show all 298)
idCompoundScoreTop Affiliating Genes
1pizotifen28 4310.6HTR2C, HTR2A, HTR1A, HTR3A
2mdma439.5SLC6A4, MAOA, HTR1A, TPH1, SLC6A2
3quipazine43 2810.5HTR1A, HTR3A, HTR2A, HTR2C
48-hydroxy-2-(di-n-propylamino)tetralin439.4SLC6A4, HTR1A, HTR3A, HTR2A
51-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane439.4HTR1A, HTR3A, HTR2A, HTR2C
65-hydroxytryptophan439.4HTR1A, HTR3A, HTR2A, TPH1, SLC6A4
7carbon-11439.4TSPO, HTR1A, MAOA, SLC6A4
8ergotamine28 43 1211.3SLC6A2, HTR1A, HTR2C, HTR3A, HTR2A
9p-chloroamphetamine439.3SLC6A2, SLC6A4, MAOA, HTR1A
10escitalopram43 49 24 1212.3SLC6A4, HTR2C, HTR2A, SLC6A2, HTR1A
11m-chlorophenylpiperazine439.3HTR1A, HTR2A, SLC6A4, HTR3A, HTR2C
12mcpp439.3HTR2C, HTR2A, HTR3A, HTR1A, SLC6A4
13sertraline43 28 49 24 1213.3SLC6A4, SLC6A2, MAOA, HTR3A, HTR1A
14methysergide43 28 1211.3MAOA, HTR2C, HTR3A, HTR2A, HTR1A
155-hydroxyindoleacetic acid43 2410.3MAOA, TPH1, SLC6A2, SLC6A4, HTR3A
16Serotonin249.2HTR2A, HTR3A, MAOA, SLC6A4, HTR1A
17ketanserin43 2810.2SLC6A4, HTR2C, HTR3A, HTR2A, HTR1A
18amitriptyline43 28 49 1212.1HTR1A, SLC6A4, HTR2A, MAOA, SLC6A2, HTR3A
19nefazodone43 49 1211.1SLC6A2, SLC6A4, HTR1A, HTR2C, HTR3A, HTR2A
20doxepin43 28 49 1212.1HTR2C, SLC6A2, SLC6A4, HTR1A, HTR2A
21imipramine43 28 49 24 1213.1HTR1A, HTR3A, HTR2A, SLC6A4, SLC6A2, MAOA
22homovanillic acid43 2410.0SLC6A4, MAOA, SLC6A2, TPH1, COMT
23amphetamine43 49 1211.0TPH1, SLC6A2, SLC6A4, NPY, MAOA, CCKBR
24mesulergine28 4310.0HTR1A, HTR2C, HTR3A, HTR2A
25yohimbine43 2 28 1211.9NPY, HTR1A, HTR2C, HTR2A, CCKBR, HTR3A
26mhpg438.9SLC6A2, SLC6A4, NPY, COMT, MAOA
27venlafaxine43 49 24 1211.9SLC6A2, SLC6A4, COMT, HTR1A, HTR3A, HTR2A
28mianserin43 28 1210.8SLC6A2, SLC6A4, MAOA, HTR1A, HTR2C, HTR3A
29risperidone43 49 28 59 24 1213.7SLC6A4, COMT, HTR1A, HTR2C, HTR3A, HTR2A
30fenfluramine43 28 1210.7SLC6A4, NPY, HTR1A, HTR2C, HTR3A, HTR2A
31methamphetamine43 49 1210.6SLC6A2, TPH1, COMT, SLC6A4, NPY, MAOA
32citalopram43 49 24 1211.6SLC6A4, MAOA, HTR1A, HTR2C, HTR3A, HTR2A
33clomipramine43 49 1210.6TSPO, HTR2A, HTR3A, HTR2C, HTR1A, MAOA
34olanzapine43 49 28 24 1212.6HTR2A, SLC6A4, COMT, HTR1A, HTR2C, HTR3A
35haloperidol43 49 28 2 1212.6TSPO, SLC6A2, SLC6A4, NPY, HTR1A, HTR3A
36acetylcholine43 49 28 24 1212.5TPH1, TSPO, SLC6A2, NPY, HTR1A, HTR2C
37amine438.4HTR3A, TPH1, HTR2C, SLC6A2, COMT, SLC6A4
38paroxetine43 49 28 1211.3SLC6A2, SLC6A4, MAOA, COMT, HTR1A, HTR3A
39maoa438.3SLC6A2, SLC6A4, MAOA, COMT, HTR2C, HTR2A
40clozapine43 28 49 1211.2HTR2A, HTR3A, HTR2C, HTR1A, COMT, SLC6A4
41nicotine43 28 49 1211.2CCKBR, NPY, COMT, TSPO, TPH1, SLC6A2
42fluvoxamine43 49 1210.1HTR2A, TSPO, TPH1, HTR3A, HTR1A, SLC6A2
43nmda43 288.9CCKBR, NPY, SLC6A4, MAOA, COMT, TSPO
44catecholamine437.8NPY, TPH1, CRHR1, MAOA, COMT, SLC6A2
45fluoxetine43 49 28 1210.7SLC6A2, SLC6A4, CRHR1, MAOA, HTR1A, HTR2C
46gaba437.6TSPO, TPH1, MAOA, CRHR1, HTR2C, NPY
47cocaine43 128.6CCKBR, HTR2C, CRHR1, NPY, COMT, TSPO
485-hydroxytryptamine437.3SLC6A2, HTR1A, HTR2A, HTR3A, HTR2C, COMT
49norepinephrine43 24 129.2TSPO, HTR2A, HTR3A, HTR2C, HTR1A, COMT
50dopamine43 28 24 129.2SLC6A2, HTR3A, HTR2C, HTR1A, COMT, CRHR1

GO Terms for genes affiliated with Generalized Anxiety Disorder

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Cellular components related to Generalized Anxiety Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neuron projectionGO:00430059.3SLC6A2, SLC6A4, RGS2, TPH1
2integral component of plasma membraneGO:00058877.0SLC6A4, CRHR1, PLXNA2, HTR1A, HTR2C, HTR3A
3plasma membraneGO:00058865.8SLC6A2, CCKBR, HTR2A, SLC6A4, RGS2, CRHR1

Biological processes related to Generalized Anxiety Disorder according to GeneCards Suite gene sharing:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1regulation of hormone secretionGO:004688310.3HTR1A, HTR2A
2monoamine transportGO:001584410.2SLC6A2, SLC6A4
3phospholipase C-activating serotonin receptor signaling pathwayGO:000720810.2HTR2C, HTR2A
4regulation of behaviorGO:005079510.1HTR2A, HTR1A
5positive regulation of phosphatidylinositol biosynthetic processGO:001051310.1HTR2A, HTR2C
6vasoconstrictionGO:00423109.9HTR1A, SLC6A4
7dopamine catabolic processGO:00424209.8COMT, MAOA
8release of sequestered calcium ion into cytosolGO:00512099.8HTR2C, HTR2A
9neurotransmitter catabolic processGO:00421359.8COMT, MAOA
10response to painGO:00482659.7COMT, SLC6A2
11digestionGO:00075869.7CCKBR, NPY, HTR3A
12feeding behaviorGO:00076319.7CCKBR, HTR2C, NPY
13neurotransmitter biosynthetic processGO:00421369.7COMT, MAOA
14response to immobilization stressGO:00359029.7CRHR1, TPH1
15serotonin receptor signaling pathwayGO:00072109.6HTR2C, HTR3A, HTR2A, HTR1A
16behavioral fear responseGO:00016629.5HTR2C, HTR1A
17behavioral response to cocaineGO:00481489.5HTR2A, CRHR1
18behavioral response to painGO:00482669.5CRHR1, TSPO
19cell proliferationGO:00082839.5NPY, HTR1A, CCKBR, TSPO
20phospholipase C-activating G-protein coupled receptor signaling pathwayGO:00072009.3HTR2C, CCKBR, CRHR1
21memoryGO:00076139.3HTR2A, CRHR1, SLC6A4
22adrenal gland developmentGO:00303259.3CRHR1, TSPO
23response to drugGO:00424938.8SLC6A2, HTR2A, SLC6A4, HTR2C, COMT, TSPO
24synaptic transmissionGO:00072688.0HTR3A, TSPO, HTR2A, HTR2C, COMT, MAOA

Molecular functions related to Generalized Anxiety Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1beta-tubulin bindingGO:00484879.8RGS2, SLC6A2
21-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine bindingGO:00718869.8HTR2A, HTR2C
3monoamine transmembrane transporter activityGO:00085049.8SLC6A4, SLC6A2
4serotonin bindingGO:00513789.6HTR2A, HTR3A, HTR2C
5serotonin receptor activityGO:00049939.4HTR1A, HTR2C, HTR3A, HTR2A
6G-protein alpha-subunit bindingGO:00019659.1HTR2A, CRHR1

Products for genes affiliated with Generalized Anxiety Disorder

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3CDC
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