MCID: GNR004
MIFTS: 55

Generalized Anxiety Disorder malady

Neuronal diseases category

Summaries for Generalized Anxiety Disorder

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 An anxiety disorder that is characterized by long-lasting anxiety that is not focused on any one object or situation.

MalaCards: Generalized Anxiety Disorder, also known as anxiety generalized, is related to anxiety disorder and panic disorder. An important gene associated with Generalized Anxiety Disorder is SLC6A2 (solute carrier family 6 (neurotransmitter transporter), member 2), and among its related pathways are Citalopram Pathway, Pharmacokinetics and Regulation of thyroid hormone activity. The compounds pizotifen and ketanserin have been mentioned in the context of this disorder. Affiliated tissues include cortex, heart and amygdala, and related mouse phenotypes are muscle and integument.

Wikipedia:63 Generalized anxiety disorder (GAD) is an anxiety disorder that is characterized by excessive,... more...

Aliases & Classifications for Generalized Anxiety Disorder

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

generalized anxiety disorder 8 10 44 60
anxiety generalized 44


External Ids:

Disease Ontology8 DOID:14320
ICD9CM27 300.02
ICD1025 F41.1

Related Diseases for Generalized Anxiety Disorder

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Generalized Anxiety Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 112)
idRelated DiseaseScoreTop Affiliating Genes
1anxiety disorder32.1HTR3A, MAOA, SLC6A4, TPH1
2panic disorder31.1CCKBR, HTR1A, HTR3A, SLC6A4, TSPO
3social phobia30.9COMT, HTR1A, HTR3A, MAOA, SLC6A4
4obsessive-compulsive disorder30.8COMT, HTR1A, HTR3A, HTR2A, MAOA, SLC6A4
5agoraphobia30.6CCKBR, HTR1A, USP39, MAOA, SLC6A2
6bipolar disorder30.6SLC6A4, HTR1A
7mood disorder30.5NPY, MAOA, SLC6A4, SLC6A2, TPH1, HTR2A
8dysthymic disorder30.4MAOA, HTR2A
9irritable bowel syndrome30.4TPH1, SLC6A4, HTR3A
10substance abuse30.3SLC6A4
11personality disorder30.3MAOA, SLC6A4, TPH1
12anorexia nervosa30.2HTR1A, HTR3A, HTR2A, NPY, MAOA, SLC6A4
13neuroleptic malignant syndrome30.0HTR1A
14chronic fatigue syndrome30.0HTR1A, MAOA, SLC6A4
15alcohol abuse30.0SLC6A4, COMT
16parkinson's disease30.0MAOA, HTR1A, COMT
17schizophrenia30.0HTR2A, COMT
18conduct disorder30.0SLC6A4, MAOA, COMT
19alcohol dependence30.0HTR2A, NPY, MAOA, SLC6A4
20attention deficit hyperactivity disorder30.0COMT, HTR2A, MAOA, SLC6A4, SLC6A2
21dementia30.0COMT, HTR1A, HTR3A, HTR2A, MAOA, TSPO
22eating disorder30.0COMT, HTR1A, HTR3A, HTR2A, NPY, SLC6A4
23major depressive disorder10.8
24pain disorder10.5
25sleep disorder10.5
26somatization disorder10.4
27sexual disorder10.3
28separation anxiety disorder10.3
29physical disorder10.3
30adjustment disorder10.2
31post-traumatic stress disorder10.2
32tic disorder10.2
33withdrawal disorder10.2
34neurotic disorder10.0
35atypical depressive disorder10.0
36cerebritis10.0
37trichotillomania10.0
38good syndrome10.0
39polycystic ovary syndrome10.0
40alexithymia10.0
41chronic tic disorder10.0
42adult syndrome10.0
43stiff-person syndrome10.0
44rumination disorder10.0
45asthma10.0
46meningioma10.0
47specific phobia10.0
48thyroiditis10.0
49image syndrome10.0
50blindness10.0TSPO

Graphical network of the top 20 diseases related to Generalized Anxiety Disorder:



Diseases related to generalized anxiety disorder

Clinical Features for Generalized Anxiety Disorder

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Drugs & Therapeutics for Generalized Anxiety Disorder

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Generalized Anxiety Disorder

Drug clinical trials:

Search ClinicalTrials for Generalized Anxiety Disorder

Search NIH Clinical Center for Generalized Anxiety Disorder

Search CenterWatch for Generalized Anxiety Disorder

Genetic Tests for Generalized Anxiety Disorder

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Anatomical Context for Generalized Anxiety Disorder

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32MalaCards
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MalaCards organs/tissues related to Generalized Anxiety Disorder:

32
Cortex, Heart, Amygdala, Cingulate cortex, Prefrontal cortex, Brain, Temporal lobe, Fetal brain, Hypothalamus, Monocytes, Thyroid, Lung, Eye, Liver, Ovary, Testes

Animal Models for Generalized Anxiety Disorder or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Generalized Anxiety Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053697.8PDPN, HTR2C, HTR3A, HTR2A, RGS2, SLC6A4
2MP:00107717.7CCKBR, PDPN, HTR2C, HTR3A, SLC6A4, SLC6A2
3MP:00053857.2COMT, CCKBR, PDPN, HTR1A, MAOA, RGS2
4MP:00053787.0PDPN, HTR2C, HTR3A, NPY, PLXNA2, SLC6A4
5MP:00036316.7COMT, CCKBR, HTR2C, HTR1A, HTR3A, NPY
6MP:00053766.5HTR2C, PDPN, CCKBR, COMT, HTR1A, HTR3A
7MP:00053865.4TPH1, COMT, CCKBR, PDPN, HTR2C, HTR1A

Publications for Generalized Anxiety Disorder

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50PubMed
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Articles related to Generalized Anxiety Disorder:

(show top 50)    (show all 552)
idTitleAuthorsYear
1
Biased attention to threat in paediatric anxiety disorders (generalized anxiety disorder, social phobia, specific phobia, separation anxiety disorder) as a function of 'distress' versus 'fear' diagnostic categorization. (23591000)
2014
2
Pharmacotherapy of generalized anxiety disorder: focus and update on pregabalin. (24308277)
2014
3
Characteristics of worry in generalized anxiety disorder. (23651607)
2013
4
A Bowen Family Systems Model of Generalized Anxiety Disorder and Romantic Relationship Distress. (24372281)
2013
5
The cost effectiveness of pharmacological treatments for generalized anxiety disorder. (23512146)
2013
6
Comparative cost analysis of generalized anxiety disorder and major depressive disorder patients in secondary care from a national hospital registry in Finland. (23931684)
2013
7
Serotonin receptor 2A (HTR2A) gene polymorphism predicts treatment response to venlafaxine XR in generalized anxiety disorder. (22006095)
2013
8
The effects of maternal major depression, generalized anxiety disorder, and panic disorder on birth weight and gestational age: a comparative study. (23751245)
2013
9
Pregabalin augmentation of antidepressants in older patients with comorbid depression and generalized anxiety disorder-an open-label study. (22431439)
2013
10
Clinical efficacy and safety of fluoxetine in generalized anxiety disorder in Chinese patients. (24204151)
2013
11
Generalized anxiety disorder and the proposed associated symptoms criterion change for DSM-5 in a treatment-seeking sample of anxious youth. (22952043)
2012
12
Cognitive and Interpersonal Moderators of Daily Co-Occurrence of Anxious and Depressed Moods in Generalized Anxiety Disorder. (23162177)
2012
13
Dimensional indicators of generalized anxiety disorder severity for DSM-V. (22245699)
2012
14
Evidence-based review of clinical outcomes of guideline-recommended pharmacotherapies for generalized anxiety disorder. (22854029)
2012
15
Central noradrenergic responsiveness to a clonidine challenge in Generalized Anxiety Disorder: a Single Photon Emission Computed Tomography study. (21926422)
2012
16
Guided internet-delivered cognitive behavior therapy for generalized anxiety disorder: a randomized controlled trial. (21770848)
2011
17
Psychopharmacological effects of oxycodone in volunteers with and without generalized anxiety disorder. (21463065)
2011
18
Treatment of generalized anxiety disorder: a comprehensive review of the literature for psychopharmacologic alternatives to newer antidepressants and benzodiazepines. (21977338)
2011
19
A randomized, controlled clinical trial: the effect of mindfulness-based cognitive therapy on generalized anxiety disorder among Chinese community patients: protocol for a randomized trial. (22126115)
2011
20
Treatment response for late-life generalized anxiety disorder: moving beyond symptom-based measures. (21964278)
2011
21
New Strategies for Combining Mindfulness with Integrative Cognitive Behavioral Therapy for the Treatment of Generalized Anxiety Disorder. (21654919)
2011
22
Intolerance of uncertainty, worry, and rumination in major depressive disorder and generalized anxiety disorder. (20439149)
2010
23
Generalized implicit fear associations in generalized anxiety disorder. (20112248)
2010
24
Limitations of the Hamilton Anxiety Rating Scale as a primary outcome measure in randomized, controlled trials of treatments for generalized anxiety disorder. (20068126)
2010
25
Incidence and risk patterns of anxiety and depressive disorders and categorization of generalized anxiety disorder. (20048222)
2010
26
Worried all the time. The facts about generalized anxiety disorder. (20110863)
2010
27
Time to relapse after 6 and 12 months' treatment of generalized anxiety disorder with venlafaxine extended release. (21135327)
2010
28
Distress and avoidance in generalized anxiety disorder: exploring the relationships with intolerance of uncertainty and worry. (19714542)
2010
29
Comparative efficacy of pregabalin and benzodiazepines in treating the psychic and somatic symptoms of generalized anxiety disorder. (19737439)
2010
30
Startle response in generalized anxiety disorder. (19105213)
2009
31
Differentiating generalized anxiety disorder from anxiety disorder not otherwise specified. (20010022)
2009
32
Generalized anxiety disorder: connections with self-reported attachment. (19187814)
2009
33
Overview of generalized anxiety disorder: epidemiology, presentation, and course. (19371500)
2009
34
Generalized anxiety disorder: between now and DSM-V. (19716993)
2009
35
Generalized anxiety disorder in older medical patients: diagnostic recognition, mental health management and service utilization. (19152056)
2009
36
Generalized anxiety disorder in a patient prior to the diagnosis of left temporal lobe meningioma: a case report. (19508884)
2009
37
Assessing health-related quality of life in generalized anxiety disorder using the Quality Of Life Enjoyment and Satisfaction Questionnaire. (19707153)
2009
38
Assessment of generalized anxiety disorder diagnostic criteria in the National Comorbidity Survey and Virginia Adult Twin Study of Psychiatric and Substance Use Disorders. (18778157)
2008
39
Amygdala and ventrolateral prefrontal cortex activation to masked angry faces in children and adolescents with generalized anxiety disorder. (18458208)
2008
40
The structure of distress following trauma: posttraumatic stress disorder, major depressive disorder, and generalized anxiety disorder. (18729617)
2008
41
Efficacy and tolerability of duloxetine in elderly patients with generalized anxiety disorder: a pooled analysis of four randomized, double-blind, placebo-controlled studies. (18478624)
2008
42
Arnold-Chiari I malformation association with generalized anxiety disorder: a case report. (18579276)
2008
43
Short-term tolerability of a nonazapirone selective serotonin 1A agonist in adults with generalized anxiety disorder: a 28-day, open-label study. (18840371)
2008
44
Neuroleptic malignant syndrome after the use of venlafaxine in a patient with generalized anxiety disorder. (16440077)
2006
45
Cognitive-behavioral therapy for comorbid generalized anxiety disorder and panic disorder with agoraphobia. (16723421)
2006
46
Serotonin transporter and tryptophan hydroxylase gene polymorphisms in Chinese patients with generalized anxiety disorder. (15722951)
2005
47
Association of a MAOA gene variant with generalized anxiety disorder, but not with panic disorder or major depression. (12555227)
2003
48
Study on anxiety and depressive disorder of inpatients in general hospital]. (12970940)
2003
49
A phase II multicenter dose-finding, efficacy and safety trial of ipsapirone in outpatients with generalized anxiety disorder. (7915845)
1994
50
Comparison of personality disorders in different anxiety disorder diagnoses: panic, agoraphobia, generalized anxiety, and social phobia. (7804388)
1994

Genetic Variations for Generalized Anxiety Disorder

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Expression for genes affiliated with Generalized Anxiety Disorder

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Generalized Anxiety Disorder

Search GEO for disease gene expression data for Generalized Anxiety Disorder.

Pathways for genes affiliated with Generalized Anxiety Disorder

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Sources:
49PharmGKB, 53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 4Cell Signaling Technology, 29KEGG
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Compounds for genes affiliated with Generalized Anxiety Disorder

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Sources:
44Novoseek, 28IUPHAR, 49PharmGKB, 11DrugBank, 24HMDB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Generalized Anxiety Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 289)
idCompoundScoreTop Affiliating Genes
1pizotifen44 2810.7HTR2A, HTR3A, HTR1A, HTR2C
2ketanserin28 4410.6HTR1A, HTR3A, HTR2A, SLC6A4
38-hydroxy-2-(di-n-propylamino)tetralin449.6HTR2A, HTR3A, SLC6A4, HTR1A
4p-chloroamphetamine449.6MAOA, SLC6A2, HTR1A, SLC6A4
5quipazine44 2810.6HTR3A, HTR2C, HTR1A, HTR2A
61-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane449.6HTR2A, HTR2C, HTR1A, HTR3A
7mdma449.6HTR1A, SLC6A4, TPH1, SLC6A2, MAOA
8carbon-11449.6HTR1A, TSPO, MAOA, SLC6A4
9sertraline44 28 49 11 2413.5MAOA, SLC6A2, SLC6A4, HTR3A, HTR1A
105-hydroxytryptophan449.5TPH1, HTR2A, SLC6A4, HTR3A, HTR1A
11ergotamine28 44 1111.5SLC6A2, HTR3A, HTR1A, HTR2A, HTR2C
12venlafaxine49 44 11 2412.4HTR3A, SLC6A2, HTR2A, HTR1A, SLC6A4
13m-chlorophenylpiperazine449.4HTR2C, HTR1A, HTR3A, HTR2A, SLC6A4
14mcpp449.4HTR2C, SLC6A4, HTR2A, HTR3A, HTR1A
15methysergide44 28 1111.4MAOA, HTR1A, HTR2A, HTR3A, HTR2C
163,4-Methylenedioxymethamphetamine119.4SLC6A2, SLC6A4, HTR2A, HTR2C
17mesulergine28 4410.4HTR2C, HTR1A, HTR2A, HTR3A
185-hydroxyindoleacetic acid44 2410.4TPH1, SLC6A2, SLC6A4, MAOA, HTR3A
19ru 2496928 4410.3HTR1A, HTR3A, HTR2A, HTR2C
20doxepin44 28 49 1112.3SLC6A4, SLC6A2, HTR1A, HTR2A, HTR2C
21MMDA119.3MAOA, SLC6A4, SLC6A2, HTR2A
22amitriptyline44 49 28 1112.3MAOA, HTR3A, HTR1A, SLC6A4, SLC6A2, HTR2A
23nefazodone44 49 1111.2HTR2C, HTR1A, SLC6A2, SLC6A4, HTR2A, HTR3A
24nmda44 2810.2TSPO, CCKBR, COMT, MAOA, HTR1A
25imipramine44 49 28 11 2413.2MAOA, HTR3A, HTR2A, HTR1A, SLC6A2, SLC6A4
26d amphetamine449.1SLC6A4, TSPO, SLC6A2, MAOA
27homovanillic acid44 2410.1SLC6A2, COMT, MAOA, TPH1, SLC6A4
28amphetamine44 1110.1TPH1, SLC6A4, MAOA, NPY, CCKBR, SLC6A2
29yohimbine44 28 2 1112.0HTR2C, HTR2A, CCKBR, NPY, HTR1A, HTR3A
30mhpg449.0COMT, NPY, MAOA, SLC6A4, SLC6A2
31mianserin28 44 1110.9HTR2C, HTR1A, HTR3A, HTR2A, MAOA, SLC6A4
32fluvoxamine44 49 1110.8HTR2A, MAOA, SLC6A4, SLC6A2, TPH1, TSPO
33risperidone28 44 49 59 11 2413.8SLC6A4, HTR2A, HTR3A, HTR1A, HTR2C, COMT
34fenfluramine28 44 1110.7HTR2A, NPY, SLC6A4, TPH1, HTR3A, HTR1A
35clomipramine44 49 1110.7TSPO, SLC6A2, SLC6A4, MAOA, HTR2A, HTR3A
36citalopram49 44 11 2411.7HTR3A, HTR1A, HTR2C, HTR2A, MAOA, SLC6A4
37methamphetamine44 49 1110.7SLC6A2, COMT, NPY, SLC6A4, TPH1, MAOA
38fluoxetine49 44 28 1111.7TPH1, SLC6A2, SLC6A4, MAOA, HTR2A, HTR3A
39haloperidol44 28 2 49 1112.7CCKBR, HTR1A, HTR3A, HTR2A, NPY, SLC6A4
40amine448.6COMT, SLC6A4, MAOA, HTR3A, HTR2C, TPH1
41gaba448.5SLC6A4, NPY, HTR3A, HTR2C, MAOA, TPH1
42acetylcholine44 49 28 11 2412.5SLC6A2, HTR3A, TSPO, TPH1, CCKBR, NPY
43paroxetine44 49 28 1111.4COMT, HTR3A, HTR1A, TPH1, SLC6A2, HTR2A
44cocaine44 119.4SLC6A2, SLC6A4, NPY, HTR2C, CCKBR, COMT
45clozapine44 28 49 1111.4COMT, HTR2C, HTR1A, HTR3A, HTR2A, SLC6A4
46maoa448.4COMT, HTR2C, HTR1A, HTR2A, MAOA, SLC6A4
47nicotine44 49 28 1111.3SLC6A2, CCKBR, SLC6A4, MAOA, COMT, TPH1
485-hydroxytryptamine447.4NPY, HTR2A, HTR3A, HTR1A, HTR2C, COMT
49norepinephrine44 11 249.4TPH1, TSPO, COMT, SLC6A2, SLC6A4, MAOA
50dopamine44 28 11 2410.2TPH1, COMT, CCKBR, TSPO, SLC6A2, SLC6A4

GO Terms for genes affiliated with Generalized Anxiety Disorder

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16Gene Ontology
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Cellular components related to Generalized Anxiety Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058876.9SLC6A2, CCKBR, PDPN, HTR2C, HTR1A, HTR3A
2plasma membraneGO:0058866.2CCKBR, PDPN, HTR2C, HTR1A, HTR3A, HTR2A

Biological processes related to Generalized Anxiety Disorder according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1regulation of hormone secretionGO:04688310.2HTR2A, HTR1A
2phospholipase C-activating serotonin receptor signaling pathwayGO:00720810.1HTR2A, HTR2C
3monoamine transportGO:01584410.1SLC6A4, SLC6A2
4positive regulation of phosphatidylinositol biosynthetic processGO:01051310.0HTR2C, HTR2A
5regulation of behaviorGO:0507959.9HTR2A, HTR1A
6dopamine catabolic processGO:0424209.8COMT, MAOA
7feeding behaviorGO:0076319.7NPY, HTR2C, CCKBR
8digestionGO:0075869.7NPY, HTR3A, CCKBR
9response to painGO:0482659.6SLC6A2, COMT
10neurotransmitter catabolic processGO:0421359.6MAOA, COMT
11serotonin receptor signaling pathwayGO:0072109.6HTR2A, HTR3A, HTR1A, HTR2C
12vasoconstrictionGO:0423109.6SLC6A4, HTR1A
13neurotransmitter biosynthetic processGO:0421369.5COMT, MAOA
14response to drugGO:0424938.9COMT, HTR2C, HTR2A, SLC6A4, TSPO
15cell proliferationGO:0082838.7CCKBR, PDPN, HTR1A, NPY, TSPO
16synaptic transmissionGO:0072688.3COMT, HTR2C, HTR3A, HTR2A, NPY, MAOA

Molecular functions related to Generalized Anxiety Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1monoamine transmembrane transporter activityGO:0085049.9SLC6A2, SLC6A4
21-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine bindingGO:0718869.5HTR2A, HTR2C
3serotonin bindingGO:0513789.5HTR2C, HTR3A, HTR2A
4serotonin receptor activityGO:0049939.3HTR2A, HTR3A, HTR1A, HTR2C

Products for genes affiliated with Generalized Anxiety Disorder

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  • Antibodies
  • Proteins
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Sources for Generalized Anxiety Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet