MCID: GNR001
MIFTS: 23

Generalized Arterial Calcification of Infancy malady

Summaries for Generalized Arterial Calcification of Infancy

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64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 Idiopathic Infantile Arterial Calcification (IIAC) also known as Arterial Calcification of Infancy,... more...

MalaCards: Generalized Arterial Calcification of Infancy, also known as arterial calcification, generalized, of infancy, is related to pseudoxanthoma elasticum and hypophosphatemia. An important gene associated with Generalized Arterial Calcification of Infancy is ENPP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1). The compounds metformin and hydroxyapatite have been mentioned in the context of this disorder. Related mouse phenotypes are other and renal/urinary system.

Description from OMIM:47 208000

Aliases & Classifications for Generalized Arterial Calcification of Infancy

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8Disease Ontology, 61UMLS, 47OMIM
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Aliases & Descriptions:

generalized arterial calcification of infancy 8
arterial calcification, generalized, of infancy 61
idiopathic infantile arterial calcification 8


External Ids:

Disease Ontology8 DOID:0050644
OMIM47 208000

Related Diseases for Generalized Arterial Calcification of Infancy

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Generalized Arterial Calcification of Infancy:



Diseases related to generalized arterial calcification of infancy

Clinical Features for Generalized Arterial Calcification of Infancy

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47OMIM
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Clinical features from OMIM:

208000

Drugs & Therapeutics for Generalized Arterial Calcification of Infancy

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5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Generalized Arterial Calcification of Infancy

Search CenterWatch for Generalized Arterial Calcification of Infancy

Genetic Tests for Generalized Arterial Calcification of Infancy

Anatomical Context for Generalized Arterial Calcification of Infancy

Animal Models for Generalized Arterial Calcification of Infancy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Generalized Arterial Calcification of Infancy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053958.9ENPP1, ABCC6, PHEX
2MP:00053678.0PHEX, FGF23, ABCC6, ACE
3MP:00053907.9PHEX, FGF23, SLC20A2, ENPP1
4MP:00053787.7ENPP1, ACE, SLC20A2, FGF23, PHEX
5MP:00053767.3ENPP1, PHEX, FGF23, ABCC6, SLC20A2, ACE

Publications for Generalized Arterial Calcification of Infancy

Genetic Variations for Generalized Arterial Calcification of Infancy

Expression for genes affiliated with Generalized Arterial Calcification of Infancy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Generalized Arterial Calcification of Infancy

Search GEO for disease gene expression data for Generalized Arterial Calcification of Infancy.

Pathways for genes affiliated with Generalized Arterial Calcification of Infancy

Compounds for genes affiliated with Generalized Arterial Calcification of Infancy

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB
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Compounds related to Generalized Arterial Calcification of Infancy according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1metformin45 50 1111.6ACE, ENPP1
2hydroxyapatite459.2ENPP1, FGF23
3phosphorus459.1FGF23, PHEX
41,25 dihydroxy vitamin d3459.0FGF23, PHEX
5sodium45 249.6ACE, SLC20A2, PHEX
6calcium45 50 11 2410.7ENPP1, ACE, FGF23, PHEX, S100A11

GO Terms for genes affiliated with Generalized Arterial Calcification of Infancy

Sources:
16Gene Ontology
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Biological processes related to Generalized Arterial Calcification of Infancy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phosphate-containing compound metabolic processGO:0067969.5ENPP1, FGF23
2cellular phosphate ion homeostasisGO:0306439.2ENPP1, FGF23

Products for genes affiliated with Generalized Arterial Calcification of Infancy

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Generalized Arterial Calcification of Infancy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet