MCID: GNR003
MIFTS: 37

Generalized Atherosclerosis malady

Categories: Cardiovascular diseases

Aliases & Classifications for Generalized Atherosclerosis

Aliases & Descriptions for Generalized Atherosclerosis:

Name: Generalized Atherosclerosis 12 14 69
Generalized and Unspecified Atherosclerosis 12
Generalised Atherosclerosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2347
ICD10 33 I70.91 I70.9
ICD9CM 35 440.9
NCIt 47 C35767
SNOMED-CT 64 367108003 39823006
UMLS 69 C0017327

Summaries for Generalized Atherosclerosis

MalaCards based summary : Generalized Atherosclerosis, also known as generalized and unspecified atherosclerosis, is related to heart disease and lupus erythematosus panniculitis. An important gene associated with Generalized Atherosclerosis is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are Lipoprotein metabolism and A-beta Pathways: Uptake and Degradation. The drugs Olmesartan and Nitric Oxide have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and kidney, and related phenotype is Decreased free cholesterol.

Related Diseases for Generalized Atherosclerosis

Diseases related to Generalized Atherosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
id Related Disease Score Top Affiliating Genes
1 heart disease 29.6 ACE CRP
2 lupus erythematosus panniculitis 10.2 ACE APOE
3 pars planitis 10.2 ACE APOE
4 atherosclerosis 10.2
5 cetp-related hyperalphalipoproteinemia 10.2 ACE APOE
6 porencephaly 2 10.2 ACE APOE
7 secretory diarrhea myopathy and deafness 10.1 ACE CRP
8 toxic myocarditis 10.1 ACE CRP
9 lupus erythematosus 10.1 ACE CRP
10 villous adenoma 10.1 ACE CRP
11 hypolipoproteinemia 10.1 ACE CRP
12 hypertrophic elongation of cervix 10.1 ACE CRP
13 ischemic optic neuropathy 10.1 ACE CRP
14 primary pigmented nodular adrenocortical disease 10.1 ABCG8 APOE
15 contagious pustular dermatitis 10.1 ACE APOE
16 focal dystonia 10.1 ACE CRP
17 schizotypal personality disorder 10.1 ACE CRP
18 choroiditis 10.1 ACE CRP
19 deafness, autosomal recessive 79 10.1 ACE CRP
20 borderline leprosy 10.1 ABCG8 APOE
21 systolic heart failure 10.1 ACE CRP
22 familial periodic paralysis 10.1 ACE CRP
23 ovary serous adenocarcinoma 10.1 APOE CRP
24 pyelonephritis 10.1 ACE CRP
25 familial nephrotic syndrome 10.1 ACE CRP
26 ceroid lipofuscinosis, neuronal, kufs type, adult onset 10.0 ACE CRP
27 congenital chloride diarrhea 10.0 ACE CRP
28 testicular lymphoma 10.0 ACE CRP
29 acute chest syndrome 10.0 ACE CRP
30 anogenital venereal wart 10.0 ACE CRP
31 chondrocalcinosis with early-onset osteoarthritis 10.0 APOE PLTP
32 calcinosis 10.0 ACE CRP
33 asphyxia neonatorum 10.0 ABCG8 ACE APOE
34 chronic myocardial ischemia 10.0 ACE CRP
35 adult t-cell leukemia 10.0 ACE CRP
36 neuropathy, hereditary sensory and autonomic, type ia 10.0 APOE PLTP
37 hypertriglyceridemia 10.0 APOE PLTP
38 cataract 5, multiple types 9.9 APOE PLTP
39 joint disorders 9.9 ACE APOE CRP
40 gait apraxia 9.9 ACE APOE CRP
41 intra-abdominal lymph node mast cell malignancy 9.9 ACE APOE CRP
42 optic nerve neoplasm 9.9 ACE APOE CRP
43 limb ischemia 9.9 ACE APOE CRP
44 diabetic encephalopathy 9.9 ACE APOE CRP
45 lipomatosis 9.9 ACE APOE CRP
46 cervix small cell carcinoma 9.9 ACE APOE CRP
47 myelophthisic anemia 9.9 ACE APOE CRP
48 budd-chiari syndrome 9.9 ACE APOE CRP
49 pyrimidine metabolic disorder 9.9 ACE APOE CRP
50 pericarditis 9.9 ACE APOE CRP

Comorbidity relations with Generalized Atherosclerosis via Phenotypic Disease Network (PDN): (show top 50) (show all 70)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Myocardial Infarction
Alzheimer Disease Anthracosis
Anxiety Disorder Aortic Atherosclerosis
Basilar Artery Insufficiency Benign Essential Hypertension
Bronchitis Bronchopneumonia
Cardiac Arrest Cerebral Atherosclerosis
Cerebral Degeneration Cerebrovascular Disease
Chronic Kidney Failure Chronic Myocardial Ischemia
Cystitis Decubitus Ulcer
Deficiency Anemia Dermatomycosis
Diabetic Polyneuropathy Dysthymic Disorder
Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation Esophagitis
Familial Atrial Fibrillation First-Degree Atrioventricular Block
Gout Heart Conduction Disease
Heart Disease Hypertension, Essential
Hypertensive Encephalopathy Hypoglycemia
Hypothyroidism Intermediate Coronary Syndrome
Intestinal Obstruction Intracranial Embolism
Intracranial Thrombosis Iron Deficiency Anemia
Ischemic Heart Disease Kidney Disease
Labyrinthitis Left Bundle Branch Hemiblock
Left Ventricular Outflow Tract Obstruction Malignant Essential Hypertension
Mesenteric Artery Ischemia Mitral Valve Disease
Myocarditis Osteoarthritis

Graphical network of the top 20 diseases related to Generalized Atherosclerosis:



Diseases related to Generalized Atherosclerosis

Symptoms & Phenotypes for Generalized Atherosclerosis

GenomeRNAi Phenotypes related to Generalized Atherosclerosis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 8.8 ABCG8 APOE PLTP

Drugs & Therapeutics for Generalized Atherosclerosis

Drugs for Generalized Atherosclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 278)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Olmesartan Approved, Investigational Phase 4 144689-24-7, 144689-63-4 158781 130881
2
Nitric Oxide Approved Phase 4,Phase 2 10102-43-9 145068
3
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
4
Clonidine Approved Phase 4 4205-90-7 2803
5
Levobupivacaine Approved Phase 4 27262-47-1 92253
6
Morphine Approved, Investigational Phase 4 57-27-2 5288826
7
Metformin Approved Phase 4,Phase 3,Phase 2 657-24-9 14219 4091
8
Everolimus Approved Phase 4,Phase 3,Phase 1 159351-69-6 6442177
9
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1 22916-47-8 4189
10
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 1 53123-88-9 5284616 6436030 46835353
11
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-78-2 2244
12
Simvastatin Approved Phase 4,Phase 3 79902-63-9 54454
13
Nicotine Approved Phase 4 54-11-5 942 89594
14
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
15
Heparin Approved, Investigational Phase 4,Phase 2 9005-49-6 772 46507594
16
Cilostazol Approved Phase 4,Phase 3 73963-72-1 2754
17
Ticlopidine Approved Phase 4,Phase 3 55142-85-3 5472
18
Insulin Glargine Approved Phase 4 160337-95-1
19
Insulin Lispro Approved Phase 4 133107-64-9
20
Zinc Approved Phase 4 7440-66-6 32051 23994
21
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
22
Ibuprofen Approved Phase 4 15687-27-1 3672
23
Naproxen Approved, Vet_approved Phase 4 22204-53-1 1302 156391
24
Darunavir Approved Phase 4 635728-49-3, 206361-99-1 213039
25
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
26
Tenofovir Approved, Investigational Phase 4 147127-20-6 464205
27
Salicylic acid Approved, Vet_approved Phase 4 69-72-7 338
28
Ticagrelor Approved Phase 4 274693-27-5 9871419
29
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 59-30-3 6037
30
Clopidogrel Approved, Nutraceutical Phase 4,Phase 3,Phase 2 120202-66-6, 113665-84-2 60606
31
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2 58-05-9 54575, 6560146 143
32 Adrenergic beta-Antagonists Phase 4,Phase 2
33
Angiotensin II Phase 4,Phase 2 68521-88-0, 11128-99-7 65143 172198
34 Angiotensin II Type 1 Receptor Blockers Phase 4
35 Angiotensin Receptor Antagonists Phase 4,Phase 2
36 Angiotensin-Converting Enzyme Inhibitors Phase 4,Phase 2
37 Angiotensinogen Phase 4,Phase 2
38 Antihypertensive Agents Phase 4,Phase 3
39 calcium channel blockers Phase 4,Phase 2
40 Calcium, Dietary Phase 4,Phase 2,Phase 3
41 diuretics Phase 4,Phase 2
42
Imidacloprid Phase 4 105827-78-9 86418
43
Olmesartan medoxomil Phase 4 144689-63-4 130881
44 Anticholesteremic Agents Phase 4,Phase 2,Phase 3
45 Antimetabolites Phase 4,Phase 2,Phase 3
46 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4,Phase 2,Phase 3
47 Hypolipidemic Agents Phase 4,Phase 2,Phase 3
48 Lipid Regulating Agents Phase 4,Phase 2,Phase 3
49 Rosuvastatin Calcium Phase 4,Phase 3,Phase 2 147098-20-2
50 Adrenergic Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 351)
id Name Status NCT ID Phase
1 Efficacy Study of Olmesartan Medoxomil on Coronary Atherosclerosis and Epicardial Adipose Tissue(EAT) Unknown status NCT02360956 Phase 4
2 Rosuvastatin Evaluation of Atherosclerotic Chinese Patients (REACH) Unknown status NCT00885872 Phase 4
3 The Prediction of Extent and Risk Profile of Coronary Atherosclerosis and Their Changes During Lipid-lowering Therapy Based on Non-invasive Techniques Unknown status NCT01773512 Phase 4
4 Study Effects of Ginkgo Biloba Extract on Endothelial Cell Function and Genetic Effects on the Response to Ginkgo Biloba Extract in Diabetic Patients With Stable Coronary Artery Disease Unknown status NCT01038050 Phase 4
5 Far Infrared Therapy on Peripheral Artery Disease in Hemodialysis Patients Unknown status NCT01095549 Phase 4
6 Global Vascular Effects of Intermittent Pneumatic Compression-Pilot Study Unknown status NCT01064323 Phase 4
7 Interest of a Bi-truncal Nerve Block (Femoral + Sciatic) Extended, Systematically Associated With General Anesthesia, in the Femoropopliteal Bypass: Study of Post-operative Analgesia and Peripheral Circulation Downstream Unknown status NCT01785693 Phase 4
8 Can Advair and Flovent Reduce Systemic Inflammation Related to Chronic Obstructive Pulmonary Disease (COPD)? A Multi-Center Randomized Controlled Trial Unknown status NCT00120978 Phase 4
9 Simvastatin Reduces Circulating Osteoprotegerin Levels in Patients With Type 2 Diabetes Completed NCT00471549 Phase 4
10 The TRUST Study - CardioVascular Imaging IMT Completed NCT02832934 Phase 4
11 Lupus Atherosclerosis Prevention Study Completed NCT00120887 Phase 4
12 The TRUST Trial - CardioVascular Imaging ECHO Completed NCT02832960 Phase 4
13 Salusin-alpha - a New Factor in the Pathogenesis of Lipid Abnormalities in Hemodialysis Patients Completed NCT01448174 Phase 4
14 Pleiotropic Effects of Atorvastatin in High Cardiovascular Risk Patients Completed NCT01013103 Phase 4
15 Carotid Plaque Screening Trial in Smokers Completed NCT00548665 Phase 4
16 The Effect of Contrast Agent on Endothelial Function in Healthy Men Completed NCT01895699 Phase 4
17 Uremic Hyperhomocysteinemia -A Folate Trial for Possible Prevention of Cardiovascular Events Completed NCT00317005 Phase 4
18 Effect of Raltegravir on Endothelial Function in HIV-Infected Patients Completed NCT00843713 Phase 4
19 Pioglitazone Regress Left Ventricular Mass in Type 2 Diabetes With Ischeamia Heart Disease Completed NCT01947790 Phase 4
20 PTA vs. Primary Stenting of SFA Using Self-Expandable Nitinol Stents Completed NCT00715416 Phase 4
21 Trial of Cilostazol in Symptomatic Intracranial Arterial Stenosis II Completed NCT00130039 Phase 4
22 Long-Term Effects of Insulin Plus Metformin Regimens on the Overall and Postprandial Glycemic Control of Patients With Type 2 Diabetes Completed NCT00191464 Phase 4
23 The Real-World Endeavor Resolute Versus XIENCE V Drug-Eluting Stent Study in Twente Completed NCT01066650 Phase 4
24 Effects of Atorvastatin on Disease Activity and HDL Cholesterol Function in Patients With Rheumatoid Arthritis Completed NCT00356473 Phase 4
25 GORE VIABAHN ENDOPROSTHESIS Peripheral Vascular Disease Study Completed NCT00228384 Phase 4
26 Prospective Randomized Evaluation Of Celecoxib Integrated Safety Vs Ibuprofen Or Naproxen Completed NCT00346216 Phase 4
27 The Safety and Efficacy of Cilostazol in Ischemic Stroke Patients With Peripheral Arterial Disease (SPAD Study) Completed NCT01188824 Phase 4
28 Effect of Sitagliptin on Progression of Coronary Intermediate Lesion Recruiting NCT02655757 Phase 4
29 Safety and Efficacy of Everolimus - Eluting Bioresorbable Vascular Scaffold for Cardiac Allograft Vasculopathy Recruiting NCT02377648 Phase 4
30 Effect of L-Thyroxine on Lipid Profiles and Atherosclerosis in Subclinical Hypothyroidism Active, not recruiting NCT01831869 Phase 4
31 Clinical Study of the Aorta-femoral Bypass and Hybrid Intervention and the Iliac Arteries With Stenting and Plasty of the Common Femoral Artery Effectiveness in Patients With the Iliac Segment and Femoral Artery Occlusive Disease (TASC C, D) Active, not recruiting NCT02580084 Phase 4
32 Sleep Disordered Breathing in Transient Ischemic Attack (TIA)/Ischemic Stroke and Continuous Positive Airway Pressure (CPAP) Treatment Efficacy Active, not recruiting NCT01097967 Phase 4
33 Study of the Effect of Atorvastatin for Reducing Aging-related Complication in HIV-infected Patients Older Than 45 Years Receiving a Protease Inhibitor-based Regimen Versus a Raltegravir-based Regimen Active, not recruiting NCT02577042 Phase 4
34 PROMUS Element Plus US Post-Approval Study Active, not recruiting NCT01589978 Phase 4
35 Routine Versus Selective Use of FFR to Guide PCI Terminated NCT02000661 Phase 4
36 Thalidomide for the Treatment of Malnutrition Inflammation Syndrome in Peritoneal Dialysis Patients Withdrawn NCT00390247 Phase 4
37 Endothelial Dysfunction in Obese Children Unknown status NCT01461226 Phase 3
38 ARISE – Aggressive Reduction of Inflammation Stops Events Unknown status NCT00066898 Phase 3
39 Diabetes Prevention Program Outcomes Study Unknown status NCT00038727 Phase 3
40 ELITE: Early Versus Late Intervention Trial With Estradiol Completed NCT00114517 Phase 2, Phase 3
41 Conjugated Linoleic Acid and Atherosclerosis Completed NCT00706745 Phase 3
42 MARS - Monitored Atherosclerosis Regression Study Completed NCT00116870 Phase 2, Phase 3
43 PROMUS Element Japan Small Vessel Trial Completed NCT01080261 Phase 3
44 Targeting Inflammation in Acute Coronary Syndrome Using Colchicine Completed NCT00754819 Phase 2, Phase 3
45 Polypill Effects on Sub Clinical Atherosclerosis (PESCA) Trial Completed NCT01326676 Phase 3
46 Glucagon-like Peptide 1 Agonist Exenatide for Improved Glucose Control and Cardiac Function in Patients With Aortocoronary Bypass Completed NCT01373216 Phase 3
47 Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance (CHARISMA) Completed NCT00050817 Phase 3
48 Stenting in Renal Dysfunction Caused by Atherosclerotic Renal Artery Stenosis Completed NCT00150943 Phase 3
49 Effect of Omega 3 Fatty Acids on Oxidative Stress in HIV Seropositive Patients Completed NCT02041520 Phase 3
50 Impact of Adalimumab Therapy on Brachial Endothelial Function and Large Artery Stiffness in Patients With Rheumatoid Arthritis Completed NCT01954381 Phase 3

Search NIH Clinical Center for Generalized Atherosclerosis

Genetic Tests for Generalized Atherosclerosis

Anatomical Context for Generalized Atherosclerosis

MalaCards organs/tissues related to Generalized Atherosclerosis:

39
Heart, Bone, Kidney

Publications for Generalized Atherosclerosis

Articles related to Generalized Atherosclerosis:

(show all 23)
id Title Authors Year
1
Abdominal Aortic Calcification Identified on Lateral Spine Images From Bone Densitometers Are a Marker of Generalized Atherosclerosis in Elderly Women. ( 26603153 )
2016
2
Involvement of the Coronary Bed in Patients with Coronary Heart Disease against the Background of Primarily Coronary and Generalized Atherosclerosis. ( 27905030 )
2016
3
Carotid Intima Media Thickness as a Reflection of Generalized Atherosclerosis is Related to Body Mass Index in Ischemic Stroke Patients. ( 23626961 )
2013
4
Association Between Renal Vasculature Changes and Generalized Atherosclerosis: An Autopsy Survey. ( 24096900 )
2013
5
Usefulness of carotid intima-media thickness measurement as an indicator of generalized atherosclerosis: findings from autopsy analysis. ( 23092826 )
2012
6
Adiposis dolorosa with hypercholesterolemia and premature severe generalized atherosclerosis. ( 19817260 )
2009
7
Plaque in superficial femoral arteries indicates generalized atherosclerosis and vulnerability to coronary death: an autopsy study. ( 18241752 )
2008
8
Re: Penile duplex pharmaco-ultrasonography of cavernous arteries in men with erectile dysfunction and generalized atherosclerosis. ( 17209882 )
2007
9
Intracardiac calcification is a marker of generalized atherosclerosis. ( 17875954 )
2007
10
Penile duplex pharmaco-ultrasonography of cavernous arteries in men with erectile dysfunction and generalized atherosclerosis. ( 16893400 )
2006
11
Initial validation of a novel rat model of vasculogenic erectile dysfunction with generalized atherosclerosis. ( 15889122 )
2005
12
Generalized atherosclerosis, cognitive decline, and depressive symptoms in old age. ( 16009894 )
2005
13
Generalized atherosclerosis sparing the transplanted kidney in Schimke disease. ( 15054643 )
2004
14
The ankle-brachial blood pressure index as a risk indicator of generalized atherosclerosis. ( 16222633 )
2002
15
Ankle brachial index as a predictor of generalized atherosclerosis. ( 11868859 )
2001
16
Secondary retroperitoneal fibrosis associated with generalized atherosclerosis. ( 18212457 )
1999
17
Carotid artery intima-media thickness as an indicator of generalized atherosclerosis. ( 7964435 )
1994
18
The use of percutaneous transluminal angioplasty for renal artery stenosis in patients with generalized atherosclerosis. ( 6211555 )
1982
19
Congenital deficiency of cyclo-oxygenase in a woman with generalized atherosclerosis. ( 7336165 )
1981
20
Generalized atherosclerosis in a dog. ( 1249925 )
1976
21
Risk factors in the pathogenesis of atherosclerotic heart disease and generalized atherosclerosis. ( 4628363 )
1972
22
Clinical studies in blood lipid metabolism. IX. Effect of lipotropic agents on serum lipid partitions in fifty patients with generalized atherosclerosis; a three year study. ( 13158314 )
1954
23
Severe generalized atherosclerosis. ( 18911030 )
1948

Variations for Generalized Atherosclerosis

Expression for Generalized Atherosclerosis

Search GEO for disease gene expression data for Generalized Atherosclerosis.

Pathways for Generalized Atherosclerosis

GO Terms for Generalized Atherosclerosis

Cellular components related to Generalized Atherosclerosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 8.92 ACE APOE CRP PLTP

Biological processes related to Generalized Atherosclerosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 lipid transport GO:0006869 9.32 APOE PLTP
2 cholesterol homeostasis GO:0042632 9.26 ABCG8 APOE
3 cholesterol efflux GO:0033344 9.16 ABCG8 APOE
4 high-density lipoprotein particle remodeling GO:0034375 8.96 APOE PLTP
5 positive regulation of cholesterol efflux GO:0010875 8.62 APOE PLTP

Molecular functions related to Generalized Atherosclerosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cholesterol transporter activity GO:0017127 8.96 ABCG8 APOE
2 low-density lipoprotein particle receptor binding GO:0050750 8.62 APOE CRP

Sources for Generalized Atherosclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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