Generalized Epilepsy malady

Wikipedia: Generalised epilepsy, also known as primary generalised epilepsy or idiopathic epilepsy, is a form of...⁴⁴ more...

MalaCards: Generalized Epilepsy, also known as epilepsy, generalized, is related to idiopathic generalized epilepsy and temporal lobe epilepsy. An important gene associated with Generalized Epilepsy is GABRD (gamma-aminobutyric acid (GABA) A receptor, delta), and among its related pathways are Antiarrhythmic Pathway, Pharmacodynamics and Sodium channels and transporters- inward current. The drugs primidone and anti-epileptic agent [epc] and the compounds ralfinamide mesylate and flecainide acetate have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are integument and hearing/vestibular/ear.

generalized epilepsy 8 epilepsy, generalized 43

epilepsy generalized 32 epilepsy 43

Diseases related to generalized epilepsy by text searches and GeneDecks gene sharing:

(show top 50)    (show all 405)

id	Related Disease	Score	Top Affiliating Genes
1	idiopathic generalized epilepsy	37.3	CLCN2, ME2, CACNB4, CACNA1H, EGI
2	temporal lobe epilepsy	35.2	SCN1B, LGI1, GRIK2, ABCB1, TSPO, SLC1A2
3	febrile seizures	35.1	KCNQ2, KCNQ3, SCN1B, SCN1A, LGI1, CHRNB2
4	generalized epilepsy with febrile seizures plus	34.9	KCNQ2, KCNQ3, SCN1B, SCN1A, LGI1, CHRNB2
5	myoclonus	34.6	SCN2A, CSTB, SLC25A22, EFHC1, EPM2AIP1, GABBR1
6	autosomal dominant nocturnal frontal lobe epilepsy	33.5	KCNQ2, KCNQ3, SCN1B, SCN1A, CHRNB2, CHRNA4
7	focal epilepsy	33.0	CLCN2, SCN1A, LGI1, GABRG2
8	intractable epilepsy	32.4	SCN2A, SCN1A, ARX, ABCB1
9	absence epilepsy	32.2	SGCZ, CLCN2, SCN1B, LGI4, CHRNA4, MTMR9
10	generalized epilepsy and paroxysmal dyskinesia	31.9	KCNT1, KCNMA1
11	severe myoclonic epilepsy of infancy (smei)	31.4	SCN1B, SCN2A, SCN1A, GABRG2
12	seizure disorder	31.2	KCNQ2, SCN2A, SCN1A
13	juvenile myoclonic epilepsy	30.5	CLCN2, CACNB4, GABRD, GABRA1
14	dravet syndrome	30.0	PCDH19, SCN1B, SCN2A, SCN9A, SCN1A, GABRG2
15	hemiplegic migraine	30.0	SCN1A, ATP1A2, CACNA1A
16	familial hemiplegic migraine	29.7	SCN1A, ATP1A2, CACNA1A
17	early myoclonic encephalopathy	29.7	SCN1A, ARX, CSTB
18	myokymia with neonatal epilepsy	29.6	KCNQ2, KCNQ3
19	epilepsies, partial	28.9	SCN1A, LGI1, CHRNA4, TSPO, GABRG2
20	epilepsy with generalized tonic-clonic seizures	28.8	SCN2A, SCN1A
21	merrf syndrome	28.8	SCN1B, SCN1A, CHRNA4, ARX, CSTB, GABRG2
22	episodic ataxia	28.8	KCNQ3, SCN2A, ATP1A2, CACNB4, CACNA1A
23	juvenile absence epilepsy	28.1	CLCN2, GRIK2, ALDH5A1, CACNA1A, CACNG3, CACNA1H
24	cerebellar ataxia	28.0	PAX6, SCN8A, SCN1A, CACNA1A, GAD1, GAD2
25	infantile epileptic encephalopathy	28.0	PCDH19, SCN1A, ARX, STXBP1
26	long qt syndrome	27.8	KCNQ2, KCNQ3, SCN1B, SCN8A, ZACN
27	epilepsy syndrome	27.8	PCDH19, CLCN2, KCNJ6, KCNJ10, KCNQ2, KCNQ3
28	ataxia	27.5	PAX6, KCNJ10, SCN2A, SCN8A, SCN1A, ATP1A2
29	childhood absence epilepsy	27.4	CLCN2, LGI4, CHRNA4, JRK, CACNA1G, CACNA1I
30	status epilepticus	27.2	SCN1A, LGI1, ALDH5A1, CACNA1A, ABCB1, HCN1
31	cerebritis	27.2	PAX6, KCNMA1, SCN1B, SCN8A, CHRNA7, CHRNB2
32	blindness	27.2	CLCN2, PAX6, SCN1A, ATP1A2, MAOA, GPR98
33	intellectual disability	27.1	PCDH19, PAX6, KCNJ6, KCNQ2, SCN1A, CHRNA7
34	febrile convulsions	27.1	KCNQ2, KCNQ3, SCN9A, SCN1A, CHRNA4, GPR98
35	seizures	27.0	SGCZ, PCDH19, CLCN2, PAX6, KCNJ6, KCNJ10
36	dementia	26.8	CHRNA7, CHRNB2, CHRNA4, MAOA, CACNA1A, HP
37	myokymia	26.6	KCNQ2, KCNQ3, CACNA1A
38	benign familial neonatal-infantile seizures	26.5	KCNQ3, SCN1B, LGI4
39	benign neonatal seizures	26.4	KCNQ2, KCNQ3
40	mental retardation syndrome	26.0	PAX6, KCNQ2, ATP1A2, ARX, MAOA, ALDH5A1
41	anxiety disorder	25.8	MAOA, TSPO, GABBR1, GAD1
42	headache	25.8	SCN1A, ATP1A2, MAOA, CACNA1A, HP, CPA6
43	ohtahara syndrome	25.8	ARX, STXBP1
44	encephalitis	25.7	SCN1A, SCN2B, LGI1, CHRNA7, ABCB1, TSPO
45	neuropathy	25.6	KCNQ2, SCN2A, SCN9A, SCN8A, LGI1, ATP1A2
46	convulsions	25.5	PCDH19, KCNQ2, KCNQ3, SCN1B, SCN2A, SCN9A
47	limbic encephalitis	25.4	LGI1, GAD1, GAD2
48	neurologic diseases	25.3	SCN8A, ATP1A2, CACNB4, CACNA1A, HP, TSPO
49	tremor	24.9	SCN8A, CACNA1A, ABCB1, STXBP1, GABRA1
50	down syndrome	24.6	KCNJ6, KCNQ2, CHRNA7, CHRNB2, CHRNA4, ALDH5A1

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 anti-epileptic agent [epc], primidone

MalaCards organs/tissues related to generalized epilepsy:

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MGI Mouse Phenotypes related to generalized epilepsy:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	integument phenotype	MP:0010771	9.0	CHRNA4, CHRNB2, CACNA1A, HCN2, ARX, SLC12A6
2	hearing/vestibular/ear phenotype	MP:0005377	9.0	GABRD, KCNJ10, SLC12A6, ABCB1, CACNB4, GPR98
3	no phenotypic analysis	MP:0003012	8.6	GABRB3, GAD2, CSTB, GLRA3, HCN1, GABRA1
4	muscle phenotype	MP:0005369	8.4	CACNA1H, TRPC4, ACADM, CSTB, GLRB, SLC4A3
5	reproductive system phenotype	MP:0005389	8.3	HCN2, CACNA1A, SCN8A, SCN1A, CHRNA7, ARX
6	growth/size phenotype	MP:0005378	6.8	GRIK2, ALDH5A1, CACNB4, CACNA1A, ARX, ARC
7	homeostasis/metabolism phenotype	MP:0005376	6.8	ABCB1, HP, CHRNA4, CHRNB2, CHRNA7, KCNQ3
8	nervous system phenotype	MP:0003631	5.8	TRPC4, HCN1, HCN2, TAP1, CSTB, SLC4A3
9	mortality/aging	MP:0010768	5.2	GLRB, HP, ABCB1, ACADM, CACNG3, CACNA1A
10	behavior/neurological phenotype	MP:0005386	4.8	KCNJ9, KCNJ10, KCNMA1, KCNQ2, KCNQ3, SCN7A

Articles related to generalized epilepsy:

(show top 50)    (show all 97)

id	Title	Authors	Year	Affiliating Genes
1	Recessive loss-of-function mutation in the pacemaker HCN2 channel causing increased neuronal excitability in a patient with idiopath ic generalized epilepsy. (22131395)	DiFrancesco J.C.... DiFrancesco D.	2011	HCN2
2	Novel I+1 and I^2 GABAA receptor subunit mutations in f amilies with idiopathic generalized epilepsy. (21714819)	Lachance-Touchette P.... Cossette P.	2011	GABRG2, GABRA1
3	Generalized epilepsy with febrile seizures plus: nove l SCN1A mutation. (20117752)	Dimova P.S.... Kremenski I.	2010	SCN1A
4	Screening of GABRB3 in French-Canadian families with idiopathic generalized epilepsy. (20550555)	Lachance-Touchette P.... Cossette P.	2010	GABRB3
5	Novel mutation of SCN1A in familial generalized epilepsy with febrile seizures plus. (20600615)	Li N.... Tang B.S.	2010	SCN1A
6	A novel inherited mutation in the voltage sensor region of SCN1A is associated with Panayiotopoulos syndrome in siblings and generalized epilepsy with febrile seizures plus. (19339291)	Livingston J.H.... Zuberi S.M.	2009	SCN1A
7	Genetic screening of two Tunisian families with generalized epilepsy with febrile seizures plus. (19236456)	Fendri-Kriaa N.... Triki C.	2009	GABRG2, SCN1A
8	Clinical analysis and screening for SCN1A gene mutat ion in two pedigrees of generalized epilepsies with febrile seizures plus (19951487)	Wang X.H.... Sun D.K.	2009	SCN1A
9	Progress in molecular genetics of generalized epilepsy with febrile seizures plus (18458705)	Sun H.H.... Zhang Y.H.	2008	GABRG2, SCN1A, SCN1B
10	The influence of C3435T polymorphism of ABCB1 gene on penetration of phenobarbital across the blood-brain barrier in patients with generalized epilepsy. (18329296)	Basic S.... Posavec A.	2008	ABCB1
11	Glutamic acid decarboxylase antibodies in idiopathic generalized epilepsy and type 1 diabetes. (17167787)	Striano P.... Striano S.	2008	GAD2
12	Mutation analysis of the hyperpolarization-activated cyclic nucleotide-gated channels HCN1 and HCN2 in idiopathic generalized epilepsy. (17931874)	Tang B.... Escayg A.	2008	HCN2, HCN1
13	A novel locus for generalized epilepsy with febrile seizures plus in French families. (18625863)	Baulac S.... Nabbout R.	2008	GABRG2, SCN1A, SCN1B
14	Generalized epilepsy with febrile seizures plus-associated sodium channel beta1 subunit mutations severely reduce beta subunit-mediated modulation of sodium channel function. (17629415)	Xu R.... Petrou S.	2007	SCN1B
15	Lack of evidence of an allelic association of a functional GABRB3 exon 1a promoter polymorphism with idiopathic generalized epilepsy. (17215107)	Hempelmann A.... Sander T.	2007	GABRB3
16	Extended spectrum of idiopathic generalized epilepsies associated with CACNA1H functional variants. (17696120)	Heron S.E.... Zamponi G.W.	2007	CACNA1H
17	Allelic association of a truncation mutation of the KCNMB3 gene with idiopathic generalized epilepsy. (16958040)	Lorenz S.... Sander T.	2007	KCNMB3
18	Idiopathic generalized epilepsy phenotypes associated with different EFHC1 mutations. (17159113)	Stogmann E.... Zimprich A.	2006	EFHC1
19	Mutations in the CLCN2 gene are a rare cause of idiopathic generalized epilepsy syndromes. (16932951)	Stogmann E.... Zimprich A.	2006	CLCN2
20	A profile of alternative RNA splicing and transcript variation of CACNA1H, a human T-channel gene candidate for idiopathic generalized epilepsies. (16565161)	Zhong X.... Agnew W.S.	2006	CACNA1H
21	Lack of an association between candidate gene loci and idiopathic generalized epilepsy in Kuwaiti Arab children. (16205844)	Haider M.Z.... Al-Bloushi M.	2005	CHRNA4, CSTB, SCN1B
22	Association analysis of malic enzyme 2 gene polymorphisms with idiopathic generalized epilepsy. (16190936)	Lenzen K.P.... Sander T.	2005	ME2
23	Malic enzyme 2 may underlie susceptibility to adolescent-onset idiopathic generalized epilepsy. (15532013)	Greenberg D.A.... Kang H.	2005	ME2
24	SCN1A mutation analysis in myoclonic astatic epilepsy and severe idiopathic generalized epilepsy of infancy with generalized tonic- clonic seizures. (15944908)	Ebach K.... Neubauer B.A.	2005	SCN1A
25	Association analysis of the Arg220His variation of the human gene encoding the GABA delta subunit with idiopathic generalized epilepsy. (16023832)	Lenzen K.P.... Sander T.	2005	GABRD
26	Generalized epilepsy with febrile seizures plus: clinical and genetic analysis of three Serbian families (16053169)	Ristic A.J.... Sokic D.	2005	GABRG2, SCN1A, SCN1B
27	Effects of Cav3.2 channel mutations linked to idiopathic generalized epilepsy. (15852375)	Khosravani H.... Zamponi G.W.	2005	CACNA1H
28	GABRD encoding a protein for extra- or peri-synaptic GABAA receptors is a susceptibility locus for generalized epilepsies. (15115768)	Dibbens L.M.... Mulley J.C.	2004	GABRD
29	Genetic variation of CACNA1H in idiopathic generalized epilepsy. (15048902)	Heron S.E.... Scheffer I.E.	2004	CACNA1H
30	Exploring new gene discoveries in idiopathic generalized epilepsy. (12752457)	Noebels J.L.	2003	ZACN
31	Two novel SCN1A missense mutations in generalized epilepsy with febrile seizures plus. (12919402)	Annesi G.... Quattrone A.	2003	SCN1A
32	An Xp; Yq translocation causing a novel contiguous gene syndrome in brothers with generalized epilepsy, ichthyosis, and attention deficits. (14636323)	Doherty M.J.... Farrell D.F.	2003	ARSE
33	Functional characterization of the D188V mutation in neuronal voltage-gated sodium channel causing generalized epilepsy with febrile seizures plus (GEFS). (12576172)	Cossette P.... Rouleau G.A.	2003	SCN1A
34	Truncation of the GABA(A)-receptor gamma2 subunit in a family with generalized epilepsy with febrile seizures plus. (11748509)	Harkin L.A.... Petrou S.	2002	GABRG2
35	Association of the 867Asp variant of the human anion exchanger 3 gene with common subtypes of idiopathic generalized epilepsy. (12399075)	Sander T.... Nurnberg P.	2002	SLC4A3
36	Generalized epilepsy with febrile seizures plus: mutation of the sodium channel subunit SCN1B. (12011299)	Wallace R.H.... Mulley J.C.	2002	SCN1B
37	Neuronal sodium-channel alpha1-subunit mutations in generalized epilepsy with febrile seizures plus. (11254444)	Wallace R.H.... Berkovic S.F.	2001	SCN1A, SCN1B
38	Association between the alpha(1a) calcium channel gene CACNA1A and idiopathic generalized epilepsy. (11342703)	Chioza B.... Makoff A.J.	2001	CACNA1A
39	Mutation analysis of the potassium chloride cotransporter KCC3 (SLC12A6) in rolandic and idiopathic generalized epilepsy. (11325574)	Steinlein O.K.... Mount D.B.	2001	SLC12A6
40	Mutation screening of the chromosome 8q24.3-human activity-regulated cytoskeleton-associated gene (ARC) in idiopathic generalized epilepsy. (10970730)	Haug K.... Heils A.	2000	ARC
41	Coding and noncoding variation of the human calcium-channel beta4- subunit gene CACNB4 in patients with idiopathic generalized epilepsy and episodic ataxia. (10762541)	Escayg A.... Meisler M.H.	2000	CACNB4
42	Association analysis between a regulatory-promoter polymorphism of the human monoamine oxidase A gene and idiopathic generalized epilepsy. (10759301)	Haug K.... Heils A.	2000	MAOA
43	No evidence for association between the KCNQ3 gene and susceptibility to idiopathic generalized epilepsy. (10996506)	Haug K.... Heils A.	2000	KCNQ3, KCNQ2
44	A second locus for familial generalized epilepsy with febrile seizures plus maps to chromosome 2q21-q33. (10486327)	Baulac S.... Leguern E.	1999	SCN1A, SCN8A, SCN2A
45	Association analysis of exonic variants of the gene encoding the GABAB receptor and idiopathic generalized epilepsy. (10402495)	Sander T.... Riess O.	1999	GABBR1
46	Febrile seizures and generalized epilepsy associated with a mutation in the Na(+)-channel beta-1 subunit gene SCN1B. (9697698)	Wallace R.H.... Mulley J.C.	1998	SCN1B
47	Possible association of a silent polymorphism in the neuronal nicotinic acetylcholine receptor subunit alpha4 with common idiopathic generalized epilepsies. (9259383)	Steinlein O.... Propping P.	1997	CHRNA4
48	Refinement of map position of the human GluR6 kainate receptor gene (GRIK2) and lack of association and linkage with idiopathic generalized epilepsies. (7675232)	Sander T.... Sailer U.	1995	GRIK2
49	Generalized epilepsy disclosing medium-chain-acyl-CoA dehydrogenase deficiency (8135611)	Chabrol B.... Pinsard N.	1993	ACADM
50	Localization of idiopathic generalized epilepsy on chromosome 6p in families of juvenile myoclonic epilepsy patients. (1922810)	Durner M.... Janz D.	1991	EGI

Genes related to generalized epilepsy according to GeneCards:

(show top 50)    (show all 83)

id	Symbol	Description	Score	GeneCards Section Context
1	GABRD	gamma-aminobutyric acid (GABA) A receptor, delta	11.1	Publications, Summaries
2	GEFSP6	Generalized epilepsy with febrile seizures plus, type 6	11.1	Aliases & Descriptions
3	SCN1B	sodium channel, voltage-gated, type I, beta subunit	11.1	Publications, Summaries
4	KCNJ10	potassium inwardly-rectifying channel, subfamily J, member 10	11.1	Publications, Summaries
5	ME2	malic enzyme 2, NAD(+)-dependent, mitochondrial	11.1	Publications, Summaries
6	CACNB4	calcium channel, voltage-dependent, beta 4 subunit	11.1	Summaries, Publications
7	GEFSP8	Generalized epilepsy with febrile seizures plus, type 8	11.1	Aliases & Descriptions
8	GABRG2	gamma-aminobutyric acid (GABA) A receptor, gamma 2	11.0	Publications
9	SCN1A	sodium channel, voltage-gated, type I, alpha subunit	11.0	Publications
10	KCNQ2	potassium voltage-gated channel, KQT-like subfamily, member 2	11.0	Publications
11	SCN2A	sodium channel, voltage-gated, type II, alpha subunit	11.0	Publications
12	PPR1	Photoparoxysmal response 1	11.0	Publications
13	EGI	epilepsy, generalized, idiopathic	11.0	Publications
14	ARC	activity-regulated cytoskeleton-associated protein	11.0	Publications
15	CLCN2	chloride channel, voltage-sensitive 2	11.0	Publications
16	KCNJ9	potassium inwardly-rectifying channel, subfamily J, member 9	11.0	Publications
17	ZACN	zinc activated ligand-gated ion channel	11.0	Publications
18	KCNMB3	potassium large conductance calcium-activated channel, subfamily M beta member 3	11.0	Publications
19	SLC4A3	solute carrier family 4, anion exchanger, member 3	11.0	Publications
20	FOPNL	FGFR1OP N-terminal like	11.0	Publications
21	MTMR9	myotubularin related protein 9	11.0	Publications
22	EFHC1	EF-hand domain (C-terminal) containing 1	11.0	Publications
23	KCNK12	potassium channel, subfamily K, member 12	11.0	Publications
24	CSTB	cystatin B (stefin B)	11.0	Publications
25	CACNA1H	calcium channel, voltage-dependent, T type, alpha 1H subunit	11.0	Publications
26	ALDH5A1	aldehyde dehydrogenase 5 family, member A1	11.0	Publications
27	GABRA1	gamma-aminobutyric acid (GABA) A receptor, alpha 1	11.0	Publications
28	CHRNA4	cholinergic receptor, nicotinic, alpha 4 (neuronal)	11.0	Publications
29	CHRNB2	cholinergic receptor, nicotinic, beta 2 (neuronal)	11.0	Publications
30	HCN2	hyperpolarization activated cyclic nucleotide-gated potassium channel 2	11.0	Publications
31	SCN7A	sodium channel, voltage-gated, type VII, alpha subunit	11.0	Publications
32	CACNA1G	calcium channel, voltage-dependent, T type, alpha 1G subunit	11.0	Publications
33	TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	11.0	Publications
34	SLC12A6	solute carrier family 12 (potassium/chloride transporters), member 6	11.0	Publications
35	SCN8A	sodium channel, voltage gated, type VIII, alpha subunit	11.0	Publications
36	KCNT1	potassium channel, subfamily T, member 1	11.0	Orthologs
37	PAX6	paired box 6	11.0	Publications
38	GLRB	glycine receptor, beta	11.0	Publications
39	ATP1A2	ATPase, Na+/K+ transporting, alpha 2 polypeptide	11.0	Publications
40	GABBR1	gamma-aminobutyric acid (GABA) B receptor, 1	11.0	Publications
41	GLRA3	glycine receptor, alpha 3	11.0	Publications
42	CHRNA7	cholinergic receptor, nicotinic, alpha 7 (neuronal)	11.0	Publications
43	GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	11.0	Publications
44	GABRB3	gamma-aminobutyric acid (GABA) A receptor, beta 3	11.0	Publications
45	MAOA	monoamine oxidase A	11.0	Publications
46	CACNA1A	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	11.0	Publications
47	HP	haptoglobin	11.0	Publications
48	SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	11.0	Publications
49	GRM4	glutamate receptor, metabotropic 4	11.0	Publications
50	SCN9A	sodium channel, voltage-gated, type IX, alpha subunit	11.0

Pathways related to generalized epilepsy according to GeneDecks:

(show top 50)    (show all 54)

id	Pathway	Score	Top Affiliating Genes
1	Antiarrhythmic Pathway, Pharmacodynamics34	10.4	HCN2, SCN1B, SCN2B, CACNA1G, CACNA1H
2	Sodium channels and transporters- inward current10	10.3	SCN8A, SCN2A, TRPC4, HCN1, HCN2, SCN1A
3	GABA signaling in brain10	10.3	GABRA1, GAD2, GAD1, GABRD, GABRG2, GABBR1
4	Cholera Infection36	10.3	SCN9A, SCN8A, SCN1A, SCN2B, SCN1B, SCN7A
5	Aldosterone Signaling in Epithelial Cells36	10.2	SCN2B, SCN9A, SCN8A, SCN1A, SCN7A, ATP1A2
6	Neuropathic Pain-Signaling in Dorsal Horn Neurons36	10.2	KCNK12, SCN7A, SCN1B, SCN9A, SCN1A, SCN8A
7	Celecoxib Pathway, Pharmacodynamics34	10.2	CACNA1A, CACNA1H, KCNQ3, CACNA1G, KCNQ2, CACNB4
8	Potassium transporters- inward current10	10.1	KCNJ9, KCNJ10, HCN1, HCN2, KCNJ6
9	Glutamic acid signaling10	10.1	GAD2, GRIK2, GRM4, SLC1A2, GAD1
10	Potassium transporters- outward current10	10.1	KCNJ6, KCNJ9, KCNQ3, KCNQ2, KCNMA1
11	Hepatic ABC Transporters36	10.0	KCNK12, ABCB1, KCNT1, ATP1A2, SLC4A3, CLCN2
12	Calcium channels10	10.0	CACNA1A, CHRNA7, CHRNB2, CHRNA4, CACNA1I, CACNA1H
13	Axon guidance38	10.0	SCN1B, SCN8A, KCNQ2, TRPC4, CACNA1H, CACNB4
14	Neuronal System38	10.0	GABRB3, GABRA1, GABRG2, HCN2, HCN1, KCNMA1
15	Cholinergic synapse20	10.0	CHRNA4, KCNJ6, KCNQ2, KCNQ3, CHRNA7, CHRNB2
16	nNOS Signaling in Skeletal Muscle36	10.0	CACNA1G, CACNA1A, CACNA1I, CACNG3, CACNB4, CACNA1H
17	DREAM Repression and Dynorphin Expression36	10.0	CACNA1H, CACNG3, CACNA1I, CACNA1A, CACNA1G, CACNB4
18	Fc-Gamma-RIIB Signaling in B-Cells36	10.0	CACNA1G, CACNA1A, CACNA1I, CACNG3, CACNA1H, CACNB4
19	Fc-GammaR Pathway36	9.9	CACNB4, CACNA1A, CACNA1I, CACNG3, CACNA1H, CACNA1G
20	Sperm Motility36	9.9	KCNT1, KCNK12, CACNA1G, CACNA1H, CACNA1I, HCN2
21	CCR5 Pathway in Macrophages36	9.9	CACNA1G, CACNA1A, CACNB4, CACNA1I, CACNG3, CACNA1H
22	BMP Pathway36	9.9	CACNA1H, CACNB4, CACNA1G, CACNA1A, CACNA1I, CACNG3
23	Caspase Cascade36	9.9	CACNG3, CACNA1A, CACNA1H, CACNA1G, CACNB4, CACNA1I
24	Transcription CREB pathway10	9.9	CACNA1A, CACNA1I, CACNG3, CACNA1H, CACNA1G, CACNB4
25	Fc-EpsilonRI Pathway36	9.9	CACNA1I, CACNA1G, CACNA1H, CACNB4, CACNG3, CACNA1A
26	PDGF Pathway36	9.9	CACNB4, CACNA1I, CACNA1G, CACNA1H, CACNA1A, CACNG3
27	Sweet Taste Signaling36	9.8	KCNK12, CACNA1H, CACNG3, CACNA1I, CACNA1A, CACNA1G
28	Androgen Signaling36	9.8	CACNB4, CACNA1G, CACNA1I, CACNG3, CACNA1H, CACNA1A
29	Melatonin Signaling36	9.8	CACNA1I, CACNA1G, CACNG3, CACNA1H, CACNA1A, CACNB4
30	Transcription_CREB pathway41	9.8	CACNB4, CACNA1G, CACNA1A, CACNG3, CACNA1I, CACNA1H
31	Calpain Protease Regulates Cellular Mechanics36	9.8	CACNA1G, CACNB4, CACNG3, CACNA1A, CACNA1I, CACNA1H
32	Cellular Effects of Sildenafil36	9.8	CACNA1G, CACNA1H, CACNG3, KCNT1, KCNK12, CACNB4
33	PKC-Theta Pathway36	9.8	CACNG3, CACNA1H, CACNA1G, CACNA1A, CACNA1I, CACNB4
34	Neuroactive ligand-receptor interaction20	9.8	TSPO, GABBR1, GABRD, GABRG2, GABRA1, GRIK2
35	NFAT Signaling and Lymphocyte Interactions36	9.8	CACNA1A, CACNA1I, CACNA1H, CACNG3, CACNB4, CACNA1G
36	ITK and TCR Signaling36	9.7	CACNA1H, CACNA1A, CACNB4, CACNA1I, CACNA1G, CACNG3
37	Dopamine-DARPP32 Feedback onto cAMP Pathway36	9.7	KCNQ2, KCNJ6, KCNJ9, KCNJ10, KCNQ3, CACNB4
38	IGF1R Signaling36	9.6	CACNA1G, CACNA1A, CACNA1H, CACNB4, CACNA1I, CACNG3
39	Intracellular Calcium Signaling36	9.6	CACNG3, CACNA1H, CACNA1A, CACNA1G, CACNB4, TRPC4
40	Presenilin-Mediated Signaling36	9.6	CACNA1H, CACNG3, CACNA1I, CACNA1A, CACNA1G, CACNB4
41	all-trans-Retinoic Acid Signaling in Brain36	9.6	CACNB4, CACNA1H, CACNA1I, CACNA1A, CACNA1G, CACNG3
42	GHRH Signaling36	9.5	CACNA1H, SCN2B, SCN9A, SCN8A, SCN1A, CACNB4
43	G-Beta Gamma Signaling36	9.5	CACNA1I, CACNA1H, CACNG3, CACNA1A, CACNA1G, CACNB4
44	CREB Pathway36	9.5	CACNA1H, CACNG3, CACNA1I, CACNA1A, CACNA1G, CACNB4
45	TCR Signaling36	9.5	CACNA1H, CACNG3, CACNA1A, CACNA1G, CACNB4, CACNA1I
46	PKA Signaling36	9.4	SCN8A, CACNA1H, CACNG3, CACNA1I, CACNA1A, CACNA1G
47	Activation of cAMP-Dependent PKA36	9.4	SCN2B, SCN1A, SCN8A, SCN9A, SCN1B, CACNA1G
48	cAMP Pathway36	9.4	CACNA1H, SCN1B, CACNA1G, CACNA1A, SCN9A, CACNG3
49	Synaptic transmission- ion currents10	9.3	KCNJ9, KCNMA1, KCNQ2, KCNQ3, SCN2A, SCN9A
50	CRHR Pathway36	9.3	CACNA1H, CACNG3, CACNA1I, CACNA1A, CACNA1G, CACNB4

Compounds related to generalized epilepsy according to GeneDecks:

(show top 50)    (show all 94)

id	Compound	Score	Top Affiliating Genes
1	ralfinamide mesylate42	10.6	SCN8A, SCN2A, SCN1B, SCN2B, SCN1A
2	flecainide acetate42	10.6	SCN1A, SCN1B, SCN2B, SCN8A, SCN2A
3	qx 314 chloride42	10.6	SCN2A, SCN8A, SCN2B, SCN1A, SCN1B
4	tetrodotoxin citrate42	10.6	SCN2A, SCN2B, SCN1A, SCN8A, SCN1B
5	vinpocetine32 42	11.5	SCN1A, SCN2B, SCN1B, SCN2A, SCN8A
6	bromazepam32 9 9	12.5	MAOA, GABRD, GABRG2, GABRA1, GABRB3
7	Talbutal9 9	11.4	GABRA1, GRIK2, CHRNA4, CHRNA7
8	estazolam32 9 9	12.4	TSPO, GABRG2, GABRA1, GABRB3, GABRD
9	pentobarbital32 9 9	12.4	GABRA1, GRIK2, CHRNA4, CHRNA7, GABBR1
10	quazepam32 9 9	12.4	GABRB3, GABRA1, GABRD, TSPO, GABRG2
11	Barbituric acid derivative9 9	11.4	GABRA1, GRIK2, CHRNA4, CHRNA7
12	Clorazepate9 9	11.4	GABRG2, GABRA1, GABRB3, GABRD, TSPO
13	Butethal9 9	11.4	GABRA1, GRIK2, CHRNA4, CHRNA7
14	clobazam34 32 9 9	13.4	GABRB3, GABRA1, GABRG2, GABRD, TSPO
15	Butalbital9 9	11.4	CHRNA7, CHRNA4, GABRA1, GRIK2
16	lorazepam32 34 9 9	13.4	TSPO, GABRD, GABRG2, GABRA1, GABRB3
17	Metharbital9 9	11.4	GABRA1, GRIK2, CHRNA4, CHRNA7
18	Temazepam9 9	11.4	TSPO, GABRB3, GABRA1, GABRG2, GABRD
19	Heptabarbital9 9	11.3	GABRA1, GRIK2, CHRNA4, CHRNA7
20	alprazolam32 9 9	12.3	GABRB3, GABRG2, GABRA1, MAOA, TSPO, GABRD
21	chlordiazepoxide32 9 9	12.3	GABRA1, GABRD, TSPO, GABRG2, GABRB3
22	Butabarbital9 9	11.3	GABRA1, GRIK2, CHRNA4, CHRNA7
23	amobarbital32 9 9	12.3	GRIK2, TSPO, GABRA1, CHRNA4, CHRNA7
24	Aprobarbital9 9	11.3	CHRNA7, CHRNA4, GRIK2, GABRA1
25	4-aminopyridine32 42	11.3	KCNQ2, CACNA1A, KCNT1, KCNMA1, KCNMB3, KCNQ3
26	clonazepam32 9 9	12.3	GABRA1, GABRB3, GABRG2, MAOA, TSPO, GABBR1
27	hypotaurine42 32 18	12.3	GLRB, GLRA3, GAD2, GAD1
28	Barbital9 9	11.3	CHRNA7, CHRNA4, GRIK2, GABRA1
29	muscimol32 42	11.1	GABRA1, TSPO, GABBR1, GABRD, GABRG2, GAD1
30	benzodiazepine32	10.1	GABRG2, GABBR1, GAD1, MAOA, TSPO
31	triazolam32 9 9	12.1	GABRG2, GABRB3, GABRD, TSPO, GABRA1
32	Methylphenobarbital9 9	11.0	GABRA1, CHRNA4, CHRNA7, GRIK2
33	zonisamide32 9 9	12.0	SCN9A, CACNA1H, CACNA1I, CACNA1G, MAOA, SCN2B
34	flurazepam32 9 9	11.9	GABRB3, TSPO, GABRD, GABRG2, GABRA1, ABCB1
35	Ketazolam9 9	10.9	ABCB1, GABRA1, GABRD, TSPO
36	nitrazepam32 9 9	11.9	GABRA1, GABRB3, SCN1A, GABRG2, GABRD, TSPO
37	midazolam32 9 9	11.9	GABRB3, GABRA1, GABRD, TSPO, ABCB1, GABRG2
38	mibefradil32 9 9	11.9	CACNA1G, CACNA1I, CACNB4, ABCB1, CACNA1H
39	diazepam32 34 9 9	12.8	GABRB3, TSPO, ABCB1, GABBR1, GABRA1, GABRG2
40	Secobarbital9 9	10.8	GABRA1, GRIK2, CHRNA4, CHRNA7
41	bicuculline32	9.8	GABBR1, TSPO, CHRNA7, GAD1
42	chlorine32 18	10.7	GABRB3, GABRA1, GABRG2, GABRD, HCN2, GLRB
43	acetylcholine32 9 18 9	12.6	GAD2, TSPO, GABBR1, GAD1, KCNQ2, CACNA1A
44	kainate32	9.5	GRIK2, GRM4, TSPO, GAD2, GABBR1, SLC1A2
45	gaba32 42	10.1	GABBR1, GABRG2, GAD1, GABRA1, GABRB3, GAD2
46	potassium32 9 18 9	12.1	KCNJ9, KCNJ6, KCNMA1, KCNMB3, GAD1, GABRG2
47	nmda32 42	9.9	KCNMA1, GAD2, KCNJ6, CHRNA7, ARC, GRIK2
48	glutamate32	8.6	ATP1A2, HP, CACNA1A, ALDH5A1, MAOA, GRM4
49	sodium32 18	9.5	KCNQ3, KCNT2, SCN7A, SCN1B, SCN2A, SCN9A
50	calcium32 9 18 9	10.1	GRM4, CACNB4, GRIK2, ARSE, CHRNA7, SCN1B

Cellular components related to generalized epilepsy according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	node of Ranvier	GO:033268	10.3	KCNQ2, SCN8A, KCNQ3, SCN2A
2	acetylcholine-gated channel complex	GO:005892	10.3	CHRNA4, CHRNB2, CHRNA7
3	chloride channel complex	GO:034707	10.2	GABRG2, CLCN2, GABRD, GLRA3, GLRB, GABRB3
4	voltage-gated sodium channel complex	GO:001518	10.2	SCN7A, SCN2B, SCN1A, SCN8A, SCN9A, SCN2A
5	axon initial segment	GO:043194	10.2	SCN8A, KCNQ3, KCNQ2
6	postsynaptic membrane	GO:045211	9.9	GABBR1, ARC, ZACN, CHRNA4, CHRNB2, CHRNA7
7	voltage-gated potassium channel complex	GO:008076	9.8	KCNJ6, KCNMA1, KCNMB3, HCN2, KCNQ2, KCNQ3
8	voltage-gated calcium channel complex	GO:005891	9.7	CACNA1I, CACNB4, CACNA1G, CACNA1A, CACNG3, CACNA1H
9	cell junction	GO:030054	9.5	GLRA3, GRIK2, ARC, CHRNA4, CHRNB2, CHRNA7
10	axon	GO:030424	9.2	SCN2A, GAD2, HCN2, HCN1, KCNJ6, ACADM
11	integral to plasma membrane	GO:005887	9.0	OPRM1, GABRG2, GABRD, GABRA1, GABBR1, SLC4A3
12	plasma membrane	GO:005886	5.4	SLC12A6, SLC4A3, OPRM1, STXBP1, SLC1A2, GABBR1

Biological processes related to generalized epilepsy according to GeneDecks:

(show all 25)

id	Name	GO ID	Score	Top Affiliating Genes
1	membrane depolarization	GO:051899	10.5	SCN1B, CACNA1A, CHRNB2, CHRNA4, CACNB4
2	gamma-aminobutyric acid signaling pathway	GO:007214	10.5	GABRA1, GABRG2, GABBR1, CACNB4, CACNA1A
3	gamma-aminobutyric acid secretion	GO:014051	10.5	TRPC4, CACNA1A, CACNB4
4	adult walking behavior	GO:007628	10.5	CACNB4, GLRB, CACNA1A, KCNJ10
5	regulation of atrial cardiomyocyte membrane depolarization	GO:060371	10.5	CACNA1G, SCN2B, SCN1B
6	response to nicotine	GO:035094	10.4	CHRNA4, CHRNB2, CHRNA7, GABBR1
7	sodium ion transport	GO:006814	10.4	ATP1A2, SCN1A, SCN8A, SCN9A, SCN2A, SCN7A
8	regulation of membrane potential	GO:042391	10.4	CACNA1G, GLRB, KCNMA1, CHRNA4, CACNA1H, HCN2
9	ion transmembrane transport	GO:034220	10.4	ATP1A2, GABRA1, GABRG2, GLRA3, GLRB, GABRB3
10	cognition	GO:050890	10.3	CHRNA4, CHRNB2, CHRNA7
11	regulation of action potential in neuron	GO:019228	10.3	GRIK2, KCNMB3, SCN9A
12	ion transport	GO:006811	10.2	CHRNB2, CHRNA7, CHRNA4, GLRB, SLC4A3, SLC12A6
13	calcium ion import	GO:070509	10.2	CACNA1G, CACNA1H, TRPC4
14	behavioral response to pain	GO:048266	10.2	SCN9A, CACNA1A, TSPO
15	neurological system process	GO:050877	10.2	CHRNB2, CHRNA4, GPR98
16	neurotransmitter biosynthetic process	GO:042136	10.1	GAD2, MAOA, GAD1
17	receptor clustering	GO:043113	10.0	GRIK2, SYNGAP1, CACNA1A
18	neurotransmitter secretion	GO:007269	9.9	MAOA, STXBP1, GAD1, GAD2, GRM4, ALDH5A1
19	glutamate decarboxylation to succinate	GO:006540	9.8	GAD1, GAD2
20	potassium ion transport	GO:006813	9.8	KCNJ10, KCNMA1, KCNMB3, KCNQ2, KCNJ6, KCNQ3
21	calcium ion transport	GO:006816	9.7	CACNG3, CHRNB2, TRPC4, CHRNA7, CHRNA4, CACNA1I
22	transmembrane transport	GO:055085	9.5	SLC1A2, GABRA1, ATP1A2, GLRA3, GLRB, ABCB1
23	axon guidance	GO:007411	9.5	PAX6, CACNB4, LGI1, ARX, CACNA1I, KCNQ2
24	transport	GO:006810	9.4	GABRB3, GRIK2, CACNA1H, CLCN2, CACNB4, ABCB1
25	synaptic transmission	GO:007268	7.4	KCNJ6, ALDH5A1, MAOA, GRM4, GRIK2, CHRNA4

Molecular functions related to generalized epilepsy according to GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	GABA-A receptor activity	GO:004890	10.4	GABRB3, GABRA1, GABRD, GABRG2
2	extracellular ligand-gated ion channel activity	GO:005230	10.4	GABRG2, GABRD, GLRA3, ZACN, GABRA1, GABRB3
3	voltage-gated sodium channel activity	GO:005248	10.4	SCN7A, SCN2A, SCN9A, SCN1A, SCN8A
4	acetylcholine-activated cation-selective channel activity	GO:004889	10.3	CHRNA4, CHRNB2, CHRNA7
5	low voltage-gated calcium channel activity	GO:008332	10.2	CACNA1H, CACNA1I, CACNA1G
6	potassium channel activity	GO:005267	10.2	KCNK12, KCNQ3, KCNQ2, HCN1
7	acetylcholine receptor activity	GO:015464	10.2	CHRNA4, CHRNB2, CHRNA7
8	voltage-gated potassium channel activity	GO:005249	10.2	KCNQ2, HCN2, HCN1, KCNQ3, KCNMA1
9	acetylcholine binding	GO:042166	10.0	CHRNA7, CHRNB2, CHRNA4
10	voltage-gated calcium channel activity	GO:005245	9.7	CACNA1A, CACNA1I, CACNG3, CACNB4