TSES
MCID: GNT033
MIFTS: 28

Genetic Prion Diseases (TSES) malady

Summaries for Genetic Prion Diseases

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19GeneReviews, 33MalaCards
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MalaCards: Genetic Prion Diseases, also known as transmissible spongiform encephalopathies, is related to gerstmann-straussler-scheinker disease and fatal familial insomnia. An important gene associated with Genetic Prion Diseases is PRNP (prion protein). The compounds guanidine hydrochloride and formate have been mentioned in the context of this disorder. Affiliated tissues include brain.

GeneReviews summary for prion

Aliases & Classifications for Genetic Prion Diseases

Sources:
19GeneReviews, 20GeneTests, 22GTR
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Aliases & Descriptions:

genetic prion diseases 19 20 22
transmissible spongiform encephalopathies 19
tses 19


Related Diseases for Genetic Prion Diseases

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Genetic Prion Diseases:



Diseases related to genetic prion diseases

Clinical Features for Genetic Prion Diseases

Drugs & Therapeutics for Genetic Prion Diseases

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Genetic Prion Diseases

Drug clinical trials:

Search ClinicalTrials for Genetic Prion Diseases

Search NIH Clinical Center for Genetic Prion Diseases

Search CenterWatch for Genetic Prion Diseases

Genetic Tests for Genetic Prion Diseases

Sources:
20GeneTests, 22GTR
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Genetic tests related to Genetic Prion Diseases:

id Genetic test Affiliating Genes
1 Genetic Prion Diseases20 22 PRNP

Anatomical Context for Genetic Prion Diseases

Sources:
33MalaCards
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MalaCards organs/tissues related to Genetic Prion Diseases:

33
Brain

Animal Models for Genetic Prion Diseases or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Genetic Prion Diseases

Sources:
51PubMed
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Articles related to Genetic Prion Diseases:

(show all 13)
idTitleAuthorsYear
1
Epitope scanning indicates structural differences in brain-derived monomeric and aggregated mutant prion proteins related to genetic prion diseases. (23808898)
2013
2
Relationships between clinicopathological features and cerebrospinal fluid biomarkers in Japanese patients with genetic prion diseases. (23555862)
2013
3
Activation of the macroautophagic system in scrapie-infected experimental animals and human genetic prion diseases. (22874564)
2012
4
Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP. (22210626)
2012
5
ApoE distribution and family history in genetic prion diseases in Germany. (18157657)
2008
6
Genetic background of human prion diseases]. (18198790)
2007
7
Clinical and genetic features of human prion diseases in Catalonia: 1993-2002. (15469448)
2004
8
Molecular genetics of human prion diseases in Germany. (10987652)
1999
9
Transmissible and genetic prion diseases share a common pathway of neurodegeneration. (10617204)
1999
10
Molecular genetics of human prion diseases. (7913754)
1994
11
Molecular genetics of prion diseases in France. French Research Group on Epidemiology of Human Spongiform Encephalopathies. (7991124)
1994
12
Genetic Prion Diseases (20301407)
1993
13
Genetic and infectious prion diseases. (8105771)
1993

Genetic Variations for Genetic Prion Diseases

Expression for genes affiliated with Genetic Prion Diseases

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Genetic Prion Diseases

Search GEO for disease gene expression data for Genetic Prion Diseases.

Pathways for genes affiliated with Genetic Prion Diseases

Compounds for genes affiliated with Genetic Prion Diseases

Sources:
45Novoseek, 11DrugBank, 24HMDB
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Compounds related to Genetic Prion Diseases according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1guanidine hydrochloride459.9PRNP
2formate459.5PRNP, APOE
3guanidine45 11 2411.5PRNP, APOE
4biotin45 11 2411.3GSS, APOE
5sodium dodecylsulfate459.1PRNP, APOE
6aspartate458.6APOE, HLA-DQB1, PRNP
7glutamate458.1GSS, PRNP, HLA-DQB1, APOE

GO Terms for genes affiliated with Genetic Prion Diseases

Sources:
16Gene Ontology
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Biological processes related to Genetic Prion Diseases according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1agingGO:0075689.3GSS, APOE
2response to cadmium ionGO:0466869.2GSS, PRNP
3response to oxidative stressGO:0069799.0GSS, PRNP

Products for genes affiliated with Genetic Prion Diseases

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Genetic Prion Diseases

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet