MCID: GNC003
MIFTS: 37

Geniculate Herpes Zoster

Categories: Rare diseases, Neuronal diseases, Infectious diseases

Aliases & Classifications for Geniculate Herpes Zoster

MalaCards integrated aliases for Geniculate Herpes Zoster:

Name: Geniculate Herpes Zoster 12 14
Herpes Zoster Oticus 12 72 49 50 41 69
Nervus Intermedius Neuralgia 12 49 69
Geniculate Neuralgia 12 49
Facial Nerve Palsy Due to Herpes Zoster Infection 49
Facial Nerve Paralysis Due to Vzv 49
Herpetic Geniculate Ganglionitis 12
Facial Nerve Palsy Due to Vzv 49
Ramsay Hunt Syndrome Type Ii 12
Ramsay Hunt Syndrome Type 2 12
Herpes Zoster Auricularis 12
Ramsay Hunt Syndrome Ii 50
Myoclonus and Ataxia 69
Ramsay Hunt Syndrome 49

Classifications:



External Ids:

Disease Ontology 12 DOID:9210
ICD10 32 B02.21
ICD9CM 34 053.11
MeSH 41 D016697
NCIt 46 C84763

Summaries for Geniculate Herpes Zoster

NIH Rare Diseases : 49 Herpes zoster oticus is a common complication of shingles, an infection caused by the varicella-zoster virus (which is the virus that also causes chickenpox). Shingles occurs in people who have had chickenpox and in whom the varicella-zoster virus becomes active again. Herpes zoster oticus is caused by the spread of the virus to facial nerves and can cause intense ear pain; a rash around the ear, mouth, face, neck, and scalp; and paralysis of the face. Other symptoms may include hearing loss, vertigo (feeling that the room is spinning), tinnitus (hearing abnormal sounds), nausea, vomiting, loss of taste in the tongue, and dry mouth and eyes. Some cases of herpes zoster oticus do not require treatment, but when treatment is needed, pain medications, antiviral drugs or corticosteroids may be prescribed. Vertigo is sometimes treated with medication as well. The prognosis of herpes zoster oticus is typically good, but in some cases hearing loss or facial paralysis may be permanent.  Last updated: 8/19/2016

MalaCards based summary : Geniculate Herpes Zoster, also known as herpes zoster oticus, is related to ramsay hunt syndrome i and geniculate ganglionitis, and has symptoms including vesicular rash of the ear or mouth, tinnitus and vertigo. An important gene associated with Geniculate Herpes Zoster is MT-TC (Mitochondrially Encoded TRNA Cysteine), and among its related pathways/superpathways is Primary immunodeficiency. Affiliated tissues include facial nerve, tongue and eye.

Disease Ontology : 12 A viral infectious disease that results_in inflammation located in facial nerve, which leads to paralysis of one side of the face, has material basis in Human herpesvirus 3, which reactivates after appearing as chickenpox in childhood. The infection has symptom vesicular rash of the ear or mouth, has symptom tinnitus, has symptom vertigo, has symptom otalgia, and has symptom headache.

NINDS : 50 Herpes zoster oticus, also called Ramsay Hunt Syndrome or Ramsay Hunt Syndrome type II, is a common complication of shingles. Shingles is an infection caused by the varicella-zoster virus, which is the virus that causes chickenpox. Shingles occurs in people who have had chickenpox and represents a reactivation of the dormant varicella-zoster virus. Herpes zoster oticus, which is caused by the spread of the varicella-zoster virus to facial nerves, is characterized by intense ear pain, a rash around the ear, mouth, face, neck, and scalp, and paralysis of facial nerves. Other symptoms may include hearing loss, vertigo (abnormal sensation of movement), and tinnitus (abnormal sounds). Taste loss in the tongue and dry mouth and eyes may also occur.

Wikipedia : 72 Ramsay Hunt syndrome type 2, also known as herpes zoster oticus, is a disorder that is caused by the... more...

Related Diseases for Geniculate Herpes Zoster

Diseases related to Geniculate Herpes Zoster via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 184)
# Related Disease Score Top Affiliating Genes
1 ramsay hunt syndrome i 12.2
2 geniculate ganglionitis 11.2
3 myasthenic syndrome, congenital, 10 10.4 CD40LG MT-TC
4 evans' syndrome 10.3 CD40LG HP
5 neuronitis 10.3 CD40LG TNFRSF10A
6 trench fever 10.3 CD40LG KANTR
7 facial hemiatrophy 10.3 CD40LG KANTR
8 brachial plexus neuritis 10.3 CD40LG KANTR
9 japanese spotted fever 10.3 CD40LG KANTR
10 central nervous system vasculitis 10.3 CD40LG TNFRSF10A
11 facial paralysis 10.3 CD40LG KANTR
12 intracranial vasospasm 10.3 HP KANTR
13 facial nerve disease 10.3 CD40LG KANTR
14 neuroretinitis 10.3 CD40LG TNFRSF10A
15 functional colonic disease 10.3 CD40LG KANTR
16 selective igg deficiency disease 10.2 CD40LG CD79A
17 c1q nephropathy 10.2 CD40LG CD79A
18 meningovascular neurosyphilis 10.2 CD40LG CD79A
19 alpha chain disease 10.2 CD40LG CD79A
20 brill-zinsser disease 10.2 CD40LG CD79A
21 exudative glomerulonephritis 10.2 CD40LG CD79A
22 cork-handlers' disease 10.2 CD40LG CD79A
23 salpingo-oophoritis 10.2 CD40LG CD79A
24 early yaws 10.2 CD40LG CD79A
25 ventilation pneumonitis 10.2 CD40LG CD79A
26 chronic interstitial cystitis 10.2 CD40LG CD79A
27 axillary adenitis 10.2 CD40LG CD79A
28 branch retinal artery occlusion 10.2 CD40LG KANTR
29 trichostrongyloidiasis 10.2 CD40LG CD79A
30 dirofilariasis 10.2 CD40LG HP
31 subacute bacterial endocarditis 10.2 CD40LG CD79A
32 heterophyiasis 10.2 CD40LG CD79A
33 immunoglobulin g deficiency 10.2 CD40LG CD79A
34 orbital granuloma 10.2 CD40LG CD79A
35 transient hypogammaglobulinemia of infancy 10.2 CD40LG CD79A
36 hyperglobulinemic purpura 10.2 CD40LG CD79A
37 gastroduodenitis 10.2 CD40LG CD79A
38 bacterial conjunctivitis 10.2 CD40LG CD79A
39 heavy chain disease 10.2 CD40LG CD79A
40 ophthalmia neonatorum 10.2 CD40LG CD79A
41 immunoglobulin a deficiency 1 10.2 CD40LG CD79A
42 parotid disease 10.2 CD40LG CD79A
43 selective immunoglobulin deficiency disease 10.2 CD40LG CD79A
44 erythema elevatum diutinum 10.2 CD40LG CD79A
45 sporotrichosis 10.2 CD40LG CD79A
46 fallopian tube disease 10.2 CD40LG CD79A
47 hyperimmunoglobulin syndrome 10.2 CD40LG CD79A
48 congenital syphilis 10.2 CD40LG CD79A
49 polyclonal hypergammaglobulinemia 10.2 CD40LG CD79A
50 monoclonal paraproteinemia 10.2 CD40LG CD79A

Graphical network of the top 20 diseases related to Geniculate Herpes Zoster:



Diseases related to Geniculate Herpes Zoster

Symptoms & Phenotypes for Geniculate Herpes Zoster

Symptoms:

12
  • vesicular rash of the ear or mouth
  • tinnitus
  • vertigo
  • otalgia
  • headache

UMLS symptoms related to Geniculate Herpes Zoster:


neuralgia, earache

Drugs & Therapeutics for Geniculate Herpes Zoster

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Transcranial Magnetic Stimulation for Facial Pain Recruiting NCT02633306

Search NIH Clinical Center for Geniculate Herpes Zoster

Cochrane evidence based reviews: herpes zoster oticus

Genetic Tests for Geniculate Herpes Zoster

Anatomical Context for Geniculate Herpes Zoster

The Foundational Model of Anatomy Ontology organs/tissues related to Geniculate Herpes Zoster:

18
Facial Nerve

MalaCards organs/tissues related to Geniculate Herpes Zoster:

38
Tongue, Eye

Publications for Geniculate Herpes Zoster

Articles related to Geniculate Herpes Zoster:

(show all 14)
# Title Authors Year
1
Test Battery of Cranial Nerves VII and VIII for Assessing Herpes Zoster Oticus. ( 25385809 )
2014
2
A case of generalized varicelliform eruption after herpes zoster oticus. ( 24335939 )
2014
3
Herpes zoster oticus: a clinical model for a transynaptic, reflex pathways, viral transmission hypotheses. ( 22709534 )
2012
4
Herpes zoster oticus (Ramsay Hunt syndrome) in children: case report and literature review. ( 22445801 )
2012
5
Prognostic factors in herpes zoster oticus (ramsay hunt syndrome). ( 21725270 )
2011
6
Herpes zoster oticus: A rare clinical entity. ( 22114399 )
2010
7
Antiviral therapy for Ramsay Hunt syndrome (herpes zoster oticus with facial palsy) in adults. ( 18843734 )
2008
8
Corticosteroids as adjuvant to antiviral treatment in Ramsay Hunt syndrome (herpes zoster oticus with facial palsy) in adults. ( 18646170 )
2008
9
Molecular temporal bone pathology: II. Ramsay Hunt syndrome (herpes zoster oticus). ( 9292598 )
1997
10
Facial weakness and rash. Ramsay Hunt syndrome (herpes zoster cephalicus, herpes zoster oticus, herpes zoster auricularis). ( 8959171 )
1996
11
Gd-DPTA enhanced MRI in Bell's palsy and herpes zoster oticus: an overview and implications for future studies. ( 8928627 )
1995
12
Gadolinium-enhanced magnetic resonance imaging of the facial nerve in herpes zoster oticus and Bell's palsy: clinical implications. ( 1882962 )
1991
13
Herpes zoster oticus and facial paralysis (Ramsay Hunt syndrome). Clinico-pathologic study and review of literature. ( 4750874 )
1973
14
Herpes zoster oticus; Ramsay Hunt syndrome; report of a case. ( 18113035 )
1949

Variations for Geniculate Herpes Zoster

Expression for Geniculate Herpes Zoster

Search GEO for disease gene expression data for Geniculate Herpes Zoster.

Pathways for Geniculate Herpes Zoster

Pathways related to Geniculate Herpes Zoster according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.19 CD40LG CD79A

GO Terms for Geniculate Herpes Zoster

Biological processes related to Geniculate Herpes Zoster according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 acute-phase response GO:0006953 8.96 HP SERPINA1
2 B cell proliferation GO:0042100 8.62 CD40LG CD79A

Sources for Geniculate Herpes Zoster

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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