MCID: GNC003
MIFTS: 32

Geniculate Herpes Zoster malady

Categories: Rare diseases, Neuronal diseases, Infectious diseases

Aliases & Classifications for Geniculate Herpes Zoster

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Aliases & Descriptions for Geniculate Herpes Zoster:

Name: Geniculate Herpes Zoster 11 13
Herpes Zoster Oticus 11 48 49 39 68
Nervus Intermedius Neuralgia 11 48 68
Facial Nerve Palsy Due to Herpes Zoster Infection 48 54
Facial Nerve Paralysis Due to Vzv 48 54
Facial Nerve Palsy Due to Vzv 48 54
Geniculate Neuralgia 11 48
 
Ramsay Hunt Syndrome 48 54
Herpetic Geniculate Ganglionitis 11
Ramsay Hunt Syndrome Type Ii 11
Ramsay Hunt Syndrome Type 2 11
Herpes Zoster Auricularis 11
Ramsay Hunt Syndrome Ii 49
Myoclonus and Ataxia 68

Characteristics:

Orphanet epidemiological data:

54
facial nerve palsy due to herpes zoster infection:
Inheritance: Not applicable; Prevalence: 1-9/100000 (United States); Age of onset: All ages; Age of death: normal life expectancy

Classifications:



External Ids:

Disease Ontology11 DOID:9210
ICD1030 B02.21
ICD9CM32 053.11
MeSH39 D016697
NCIt45 C84763
Orphanet54 ORPHA3020
ICD10 via Orphanet31 B02.2+, G53.0*

Summaries for Geniculate Herpes Zoster

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NIH Rare Diseases:48 Herpes zoster oticus is a common complication of shingles, an infection caused by the varicella-zoster virus (which is the virus that also causes chickenpox). Shingles occurs in people who have had chickenpox and in whom the varicella-zoster virus becomes active again. Herpes zoster oticus is caused by the spread of the virus to facial nerves and can cause intense ear pain; a rash around the ear, mouth, face, neck, and scalp; and paralysis of the face. Other symptoms may include hearing loss, vertigo (feeling that the room is spinning), tinnitus (hearing abnormal sounds), nausea, vomiting, loss of taste in the tongue, and dry mouth and eyes. Some cases of herpes zoster oticus do not require treatment, but when treatment is needed, pain medications, antiviral drugs or corticosteroids may be prescribed. Vertigo is sometimes treated with medication as well. The prognosis of herpes zoster oticus is typically good, but in some cases hearing loss or facial paralysis may be permanent.  Last updated: 8/19/2016

MalaCards based summary: Geniculate Herpes Zoster, also known as herpes zoster oticus, is related to ramsay hunt syndrome i and geniculate ganglionitis, and has symptoms including vesicular rash of the ear or mouth, tinnitus and vertigo. An important gene associated with Geniculate Herpes Zoster is MT-TC (Mitochondrially Encoded TRNA Cysteine), and among its related pathways is Primary immunodeficiency. Affiliated tissues include facial nerve, tongue and eye.

NINDS:49 Herpes zoster oticus, also called Ramsay Hunt Syndrome or Ramsay Hunt Syndrome type II, is a common complication of shingles. Shingles is an infection caused by the varicella-zoster virus, which is the virus that causes chickenpox. Shingles occurs in people who have had chickenpox and represents a reactivation of the dormant varicella-zoster virus. Herpes zoster oticus, which is caused by the spread of the varicella-zoster virus to facial nerves, is characterized by intense ear pain, a rash around the ear, mouth, face, neck, and scalp, and paralysis of facial nerves. Other symptoms may include hearing loss, vertigo (abnormal sensation of movement), and tinnitus (abnormal sounds). Taste loss in the tongue and dry mouth and eyes may also occur.

Disease Ontology:11 A viral infectious disease that results in inflammation located in facial nerve, which leads to paralysis of one side of the face, has material basis in Human herpesvirus 3, which reactivates after appearing as chickenpox in childhood. The infection has symptom vesicular rash of the ear or mouth, has symptom tinnitus, has symptom vertigo, has symptom otalgia, and has symptom headache.

Wikipedia:71 Ramsay Hunt syndrome type 2, also known as herpes zoster oticus, is a disorder that is caused by the... more...

Related Diseases for Geniculate Herpes Zoster

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Diseases related to Geniculate Herpes Zoster via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 180)
idRelated DiseaseScoreTop Affiliating Genes
1ramsay hunt syndrome i12.1
2geniculate ganglionitis11.1
3waldeyer's ring cancer10.4CD40LG, HP
4rickettsialpox10.4CD40LG, KANTR
5facial nerve neoplasm10.4CD40LG, KANTR
6brachial plexus neuropathy10.4CD40LG, KANTR
7rocky mountain spotted fever10.4CD40LG, KANTR
8conventional leiomyosarcoma10.4CD40LG, TNFRSF10A
9urinary schistosomiasis10.3CD40LG, KANTR
10bladder squamous papilloma10.3HP, KANTR
11american histoplasmosis10.3CD40LG, KANTR
12lynch syndrome10.3CD40LG, KANTR
13malignant hypertension10.3CD40LG, HP
14calcific tendinitis10.3CD40LG, CD79A
15medullary sponge kidney10.3CD40LG, CD79A
16variola major10.3CD40LG, CD79A
17mu chain disease10.3CD40LG, CD79A
18retinal cancer10.3CD40LG, CD79A
19focal embolic glomerulonephritis10.3CD40LG, CD79A
20endometrial stromal nodule10.3CD40LG, CD79A
21chronic cystitis10.3CD40LG, CD79A
22hemolytic-uremic syndrome10.3CD40LG, CD79A
23partial motor epilepsy10.3CD40LG, CD79A
24benign meningioma10.3CD40LG, CD79A
25parasitic helminthiasis infectious disease10.3CD40LG, CD79A
26occlusion of gallbladder10.3CD40LG, CD79A
27renovascular hypertension10.3CD40LG, HP
28viral meningitis10.3CD40LG, CD79A
29substance-induced psychosis10.3CD40LG, CD79A
30gamma heavy chain disease10.3CD40LG, CD79A
31regional ureteric cancer10.3CD40LG, CD79A
32arteriosclerosis10.3CD40LG, CD79A
33bacterial conjunctivitis10.3CD40LG, CD79A
34deep keratitis10.3CD40LG, CD79A
35monoclonal paraproteinemia10.3CD40LG, CD79A
36cockayne syndrome10.3CD40LG, CD79A
37juvenile type testicular granulosa cell tumor10.3CD40LG, CD79A
38testicular brenner tumor10.3CD40LG, CD79A
39diabetic angiopathy10.3CD40LG, CD79A
40fallopian tube leiomyosarcoma10.3CD40LG, CD79A
41adult extraosseous chondrosarcoma10.3CD40LG, CD79A
42brucella abortus brucellosis10.3CD40LG, CD79A
43ganglioneuroblastoma10.3CD40LG, CD79A
44intestinal pseudo-obstruction10.3CD40LG, KANTR
45small intestinal vasoactive intestinal peptide producing tumor10.3CD40LG, CD79A
46b cell linker protein deficiency10.3CD40LG, CD79A
47post-traumatic stress disorder10.3CD40LG, CD79A
48psoriasis10.3CD40LG, CD79A
49spinocerebellar ataxia, autosomal recessive 1010.3CD40LG, CD79A
50adie pupil10.3CD40LG, CD79A

Comorbidity relations with Geniculate Herpes Zoster via Phenotypic Disease Network (PDN):


Facial Paralysis

Graphical network of the top 20 diseases related to Geniculate Herpes Zoster:



Diseases related to geniculate herpes zoster

Symptoms & Phenotypes for Geniculate Herpes Zoster

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Symptoms:

 11 (show all 5)
  • vesicular rash of the ear or mouth
  • tinnitus
  • vertigo
  • otalgia
  • headache

UMLS symptoms related to Geniculate Herpes Zoster:


pain of ear structure, neuralgia, earache, pain

Drugs & Therapeutics for Geniculate Herpes Zoster

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Transcranial Magnetic Stimulation for Facial PainRecruitingNCT02633306Phase 1

Search NIH Clinical Center for Geniculate Herpes Zoster


Cochrane evidence based reviews: herpes zoster oticus

Genetic Tests for Geniculate Herpes Zoster

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Anatomical Context for Geniculate Herpes Zoster

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MalaCards organs/tissues related to Geniculate Herpes Zoster:

36
Tongue, Eye

FMA organs/tissues related to Geniculate Herpes Zoster:

17
Facial nerve

Publications for Geniculate Herpes Zoster

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Variations for Geniculate Herpes Zoster

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Expression for genes affiliated with Geniculate Herpes Zoster

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Search GEO for disease gene expression data for Geniculate Herpes Zoster.

Pathways for genes affiliated with Geniculate Herpes Zoster

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Pathways related to Geniculate Herpes Zoster according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.4CD40LG, CD79A

GO Terms for genes affiliated with Geniculate Herpes Zoster

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Biological processes related to Geniculate Herpes Zoster according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1acute-phase responseGO:00069539.6HP, SERPINA1
2B cell proliferationGO:00421009.4CD40LG, CD79A

Sources for Geniculate Herpes Zoster

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet