MCID: GNT003
MIFTS: 62

Genital Herpes malady

Reproductive diseases category

Summaries for Genital Herpes

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Sources:
8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Genital herpes is a sexually transmitted disease (std) caused by a herpes simplex virus (hsv). it can cause sores on your genital or rectal area, buttocks, and thighs. you can get it from having sex, even oral sex. the virus can spread even when sores are not present. mothers can also infect their babies during childbirth. symptoms of herpes are called outbreaks. you usually get sores near the area where the virus has entered the body. they turn into blisters, become itchy and painful, and then heal. sometimes people do not know they have herpes because they have no symptoms or very mild symptoms. the virus can be more serious in newborn babies or in people with weak immune systems. most people have outbreaks several times a year. over time, you get them less often and the symptoms become milder. the virus stays in your body for life. medicines do not cure genital herpes, but they can help your body fight the virus. this can help lessen symptoms, decrease outbreaks, and lower the risk of passing the virus to others. correct usage of latex condoms can reduce, but not eliminate, the risk of catching or spreading herpes. nih: national institute of allergy and infectious diseases

MalaCards: Genital Herpes, also known as other genital herpes, is related to herpes simplex and meningitis, and has symptoms including swollen gl, fever and sores. An important gene associated with Genital Herpes is DARC (Duffy blood group, atypical chemokine receptor), and among its related pathways are Rheumatoid arthritis and Immune response IL-12-induced IFN-gamma production. The drugs acyclovir and interferon alfa-2b and the compounds endotoxin and gm-csf have been mentioned in the context of this disorder. Affiliated tissues include rectum, genital system and testes, and related mouse phenotypes are hematopoietic system and immune system.

Disease Ontology:8 A herpes simplex that results in infection located in genital system, or located in rectum, has material basis in human herpesvirus 1 or has material basis in human herpesvirus 2, which is transmitted by sexual contact. the infection has symptom sores, has symptom fever, and has symptom swollen glands.

CDC:3 Genital herpes is a common STD, and most people with genital herpes infection do not know they have it.

Wikipedia:63 Herpes genitalis (or genital herpes) is a genital infection caused by the herpes simplex virus. It is... more...

Aliases & Classifications for Genital Herpes

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


Aliases & Descriptions:

genital herpes 8 10 44 33 60
other genital herpes 8 60
genital herpes unspecified 8
genital herpes simplex nos 8
genital herpes simplex 8
virus-genital herpes 8
herpes genitalis 8
herpes genitalia 8
venereal herpes 8


External Ids:

Disease Ontology8 DOID:8704
ICD9CM27 054.1, 054.10
NCIt39 C14364
MeSH34 D006558

Related Diseases for Genital Herpes

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Genital Herpes:



Diseases related to genital herpes

Clinical Features for Genital Herpes

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Sources:
8Disease Ontology
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Symptoms:

8
  • swollen gl
  • fever
  • sores

Drugs & Therapeutics for Genital Herpes

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Genital Herpes

Drug clinical trials:

Search ClinicalTrials for Genital Herpes

Search NIH Clinical Center for Genital Herpes

Search CenterWatch for Genital Herpes

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Genital Herpes

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Anatomical Context for Genital Herpes

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Sources:
32MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Genital Herpes:

32
Testes, T cells, Nk cells, B cells, Skin, Cervix, Myeloid

FMA organs/tissues related to Genital Herpes:

14
Rectum, Genital system

Animal Models for Genital Herpes or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Genital Herpes:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.6CCL3, TLR2, APOE, HLA-B, ZBTB32, TBX21
2MP:00053878.1DARC, CCL5, CCL3, TLR2, APOE, HLA-B

Publications for Genital Herpes

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Sources:
50PubMed
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Articles related to Genital Herpes:

(show top 50)    (show all 523)
idTitleAuthorsYear
1
Sex differences in health care provider communication during genital herpes care and patients' health outcomes. (24015854)
2013
2
Evaluation of the activity and safety of CS 21 barrier genital gel(Ar) compared to topical aciclovir and placebo in symptoms of genital herpes recurrences: a randomized clinical trial. (24010876)
2013
3
Genital Herpes. (23910593)
2013
4
A Paradigm Shift: Vaccine-Induced Antibodies as an Immune Correlate of Protection Against Herpes Simplex Virus Type 1 Genital Herpes. (24285847)
2013
5
Safety and immunogenicity of a glycoprotein D genital herpes vaccine in healthy girls 10-17 years of age: results from a randomised, controlled, double-blind trial. (23850416)
2013
6
Herpes simplex virus type 1 is the main cause of genital herpes in women of Natal, Brazil. (22424592)
2012
7
Immunity to ocular and genital herpes simplex viruses infections. (23326289)
2012
8
Therapeutic vaccine for treatment of genital herpes enters phase 2. (23980267)
2012
9
Genital herpes in Canada: Deciphering the hidden epidemic. (23450170)
2012
10
Evaluation of patients' preferences for genital herpes treatment. (21844733)
2011
11
What you need to know about genital herpes. (21670657)
2011
12
Survey of diagnostic services for genital herpes in fourteen countries in Eastern Europe. (21369687)
2011
13
Characteristics associated with genital herpes testing among young adults: assessing factors from two national data sets. (21186443)
2011
14
Genital herpes evaluation by quantitative TaqMan PCR: correlating single detection and quantity of HSV-2 DNA in cervicovaginal lavage fluids with cross-sectional and longitudinal clinical data. (21087488)
2010
15
Suppressive valacyclovir therapy to reduce genital herpes transmission: good public health policy? (19753286)
2009
16
Efficiency of anaferon in complex therapy of genital herpes. (20027352)
2009
17
Estradiol improves genital herpes vaccine efficacy in mice. (19660586)
2009
18
Replication-defective virus vaccine-induced protection of mice from genital herpes simplex virus 2 requires CD4 T cells. (18410949)
2008
19
Governing the contagious body: genital herpes, contagion and technologies of the self. (18400830)
2008
20
Single-day, patient-initiated famciclovir therapy versus 3-day valacyclovir regimen for recurrent genital herpes: a randomized, double-blind, comparative trial. (18637755)
2008
21
Candidate microbicide PPCM blocks human immunodeficiency virus type 1 infection in cell and tissue cultures and prevents genital herpes in a murine model. (18434407)
2008
22
Susceptibility of CCR5-deficient mice to genital herpes simplex virus type 2 is linked to NK cell mobilization. (17267483)
2007
23
A recombinant multivalent combination vaccine protects against Chlamydia and genital herpes. (17094789)
2007
24
Chronic genital herpes and disclosure.... The influence of stigma. (17784999)
2007
25
Imiquimod 5% cream for the treatment of recurrent, acyclovir-resistant genital herpes. (16421805)
2006
26
Performance of a novel test for IgM and IgG antibodies in subjects with culture-documented genital herpes simplex virus-1 or -2 infection. (16643524)
2006
27
Single-day, patient-initiated famciclovir therapy for recurrent genital herpes: a randomized, double-blind, placebo-controlled trial. (16323085)
2006
28
What you need to know about genital herpes. (17019327)
2006
29
Male circumcision and risk of syphilis, chancroid, and genital herpes: a systematic review and meta-analysis. (16581731)
2006
30
Quantification of poly(I:C)-mediated protection against genital herpes simplex virus type 2 infection. (17005677)
2006
31
Knowledge of partners' genital herpes protects against herpes simplex virus type 2 acquisition. (16741881)
2006
32
Characterization of the IFN-gamma T-cell responses to immediate early antigens in humans with genital herpes. (16822314)
2006
33
Managing patients with genital herpes and their sexual partners. (15963881)
2005
34
Neonatal genital herpes simplex virus type 1 infection after Jewish ritual circumcision: modern medicine and religious tradition. (15286266)
2004
35
Predominance of herpes simplex virus type 1 from patients with genital herpes in Nova Scotia. (18159431)
2003
36
Natural history of genital herpes simplex virus type 1 infection. (12567178)
2003
37
Expectant management of preterm premature rupture of membranes complicated by active recurrent genital herpes. (12824992)
2003
38
A protective role of locally administered immunostimulatory CpG oligodeoxynucleotide in a mouse model of genital herpes infection. (12502811)
2003
39
Aborted genital herpes simplex virus lesions: findings from a randomised controlled trial with valaciclovir. (12473805)
2002
40
Rising incidence of genital herpes over two decades in a sexually transmitted disease clinic in north India. (11890299)
2002
41
Famciclovir vs. aciclovir in immunocompetent patients with recurrent genital herpes infections: a parallel-groups, randomized, double-blind clinical trial. (11298543)
2001
42
New hope for genital herpes treatment. (11323056)
2001
43
Effect of condoms on reducing genital herpes transmission. (11694144)
2001
44
Public Health Strategies to Prevent Genital Herpes: Where Do We Stand? (11095834)
2000
45
Quality of life and use of health care among people with genital herpes in France. (10494718)
1999
46
Valacyclovir. New indication: for genital herpes, simpler administration. (10424269)
1999
47
National guideline for the management of genital herpes. Clinical Effectiveness Group (Association of Genitourinary Medicine and the Medical Society for the Study of Venereal Diseases). (10616378)
1999
48
Recovery of cytomegalovirus and herpes simplex virus from upper and lower genital tract specimens obtained from women with pelvic inflammatory disease. (9207384)
1997
49
Immunization with recombinant varicella-zoster virus expressing herpes simplex virus type 2 glycoprotein D reduces the severity of genital herpes in guinea pigs. (7494331)
1995
50
Inflammatory sensory polyradiculopathy and reactivated peripheral nervous system infection in a genital herpes model. (3039065)
1987

Genetic Variations for Genital Herpes

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Expression for genes affiliated with Genital Herpes

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Genital Herpes

Search GEO for disease gene expression data for Genital Herpes.

Pathways for genes affiliated with Genital Herpes

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Sources:
29KEGG, 12EMD Millipore, 37NCBI BioSystems Database
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Pathways related to Genital Herpes according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3TLR2
2
Hide members
9.7IL4, TBX21, CCL3
3
Hide members
9.3NXF1, IL4, HLA-B, TLR2, CCL5

Compounds for genes affiliated with Genital Herpes

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Genital Herpes according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
1endotoxin4410.7DEFB4A
2gm-csf44 2811.7CCL5
3cycloheximide4410.6TLR2
4anaphylatoxin4410.4IL4, CCL5
5h2o24410.3CCL3
6ivermectin44 1111.3CCL5, IL4
7donepezil44 11 2412.2IL4, APOE
8amphotericin b4410.2IL4, TLR2, CCL5
9dexamethasone44 49 28 1113.2CCL5, TLR2, DEFB4A
10hbd24410.2DEFB4A, TLR2
11mip 1alpha4410.1IL4, CCL3, CCL5
12pranlukast44 28 1112.1IL4, CCL5
13methacholine44 1111.0IL4, CCL3, CCL5
14tarc4410.0IL4, CCL3, CCL5
15mcp 14410.0CCL3, CCL5
16ccl344 2811.0TLR2, CCL3, CCL5
17ccl444 2811.0CCL5, CCL3, TLR2
18pdtc4410.0IL4, CCL3, CCL5
19ribavirin44 49 1112.0CCL3, HLA-B, IL4
20peptidoglycan44 2810.9DEFB4A, TLR2, CCL3, CCL5
21bleomycin44 1110.9CCL3, APOE, IL4
22poly(i-c)449.9IL4, TLR2, CCL3, CCL5
23sp 60012544 5910.9DEFB4A, TLR2, CCL3, CCL5
24lipoteichoic acid449.9CCL3, TLR2, HLA-B, DEFB4A
25leukotriene b444 59 2411.9TLR2, CCL3, CCL5
26il 10449.9CCL5, CCL3, TLR2, IL4
27ritonavir44 49 1111.9CCL5, CCL3, APOE, IL4
28polyinosinic-polycytidylic acid449.9CCL3, TLR2, HLA-B, IL4
29ionomycin449.8IL4, TLR2, CCL3, CCL5
30latex449.8CCL3, TLR2, HLA-B
31glatiramer acetate44 1110.8IL4, CCL5
32ribonucleic acid449.7CCL5, CCL3, TLR2, HLA-B
33sb 20358044 5910.7CCL5, CCL3, TLR2, DEFB4A, IL4
34homocysteine44 2410.7APOE, CCL3, CCL5
35histamine44 28 2411.7CCL5, CCL3, TLR2, DEFB4A, IL4
36simvastatin44 49 59 28 11 2414.7IL4, APOE, TLR2, CCL3, CCL5
37tacrolimus44 49 1111.6CCL5, CCL3, TLR2, HLA-B, IL4
38rantes449.5DARC, IL4, DEFB4A, HLA-B, TLR2, CCL3
39pd 98,059449.4CCL5, CCL3, TLR2, DEFB4A
40cyclosporin a44 28 5911.4CCL5, CCL3, TLR2, APOE, HLA-B, IL4
41cholesterol44 28 11 2412.3CCL5, CCL3, TLR2, APOE, HLA-B
42cysteine449.2CCL5, CCL3, TLR2, APOE, DEFB4A, NFU1

GO Terms for genes affiliated with Genital Herpes

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16Gene Ontology
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Biological processes related to Genital Herpes according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of isotype switching to IgG isotypesGO:04830410.2IL4, TBX21
2positive regulation of natural killer cell chemotaxisGO:200050310.1CCL3, CCL5
3eosinophil chemotaxisGO:04824510.0CCL5, CCL3
4lipopolysaccharide-mediated signaling pathwayGO:0316639.9TLR2, CCL3, CCL5
5negative regulation by host of viral transcriptionGO:0439229.9CCL3, CCL5
6monocyte chemotaxisGO:0025489.9CCL3, CCL5
7cellular response to interleukin-1GO:0713479.9CCL5, CCL3, APOE
8macrophage chemotaxisGO:0482469.8CCL5, CCL3
9cellular calcium ion homeostasisGO:0068749.7APOE, CCL3, CCL5
10chemotaxisGO:0069359.7IL4, DEFB4A, CCL3, CCL5
11inflammatory responseGO:0069549.2DARC, TLR2, CCL3, CCL5

Molecular functions related to Genital Herpes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CCR1 chemokine receptor bindingGO:0317269.9CCL3, CCL5
2CCR5 chemokine receptor bindingGO:0317309.8CCL3, CCL5
3phospholipase activator activityGO:0160049.6CCL3, CCL5

Products for genes affiliated with Genital Herpes

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Genital Herpes

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet