MCID: GNT003
MIFTS: 62

Genital Herpes malady

Reproductive diseases category

Summaries for Genital Herpes

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Sources:
8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Genital herpes is a sexually transmitted disease (std) caused by a herpes simplex virus (hsv). it can cause sores on your genital or rectal area, buttocks, and thighs. you can get it from having sex, even oral sex. the virus can spread even when sores are not present. mothers can also infect their babies during childbirth. symptoms of herpes are called outbreaks. you usually get sores near the area where the virus has entered the body. they turn into blisters, become itchy and painful, and then heal. sometimes people do not know they have herpes because they have no symptoms or very mild symptoms. the virus can be more serious in newborn babies or in people with weak immune systems. most people have outbreaks several times a year. over time, you get them less often and the symptoms become milder. the virus stays in your body for life. medicines do not cure genital herpes, but they can help your body fight the virus. this can help lessen symptoms, decrease outbreaks, and lower the risk of passing the virus to others. correct usage of latex condoms can reduce, but not eliminate, the risk of catching or spreading herpes. nih: national institute of allergy and infectious diseases

MalaCards: Genital Herpes, also known as other genital herpes, is related to herpes simplex and meningitis, and has symptoms including swollen gl, fever and sores. An important gene associated with Genital Herpes is DARC (Duffy blood group, atypical chemokine receptor), and among its related pathways are Rheumatoid arthritis and Immune response IL-12-induced IFN-gamma production. The drugs acyclovir and interferon alfa-2b and the compounds endotoxin and gm-csf have been mentioned in the context of this disorder. Affiliated tissues include rectum, genital system and testes, and related mouse phenotypes are hematopoietic system and immune system.

Disease Ontology:8 A herpes simplex that results in infection located in genital system, or located in rectum, has material basis in human herpesvirus 1 or has material basis in human herpesvirus 2, which is transmitted by sexual contact. the infection has symptom sores, has symptom fever, and has symptom swollen glands.

CDC:3 Genital herpes is a common STD, and most people with genital herpes infection do not know they have it.

Wikipedia:63 Herpes genitalis (or genital herpes) is a genital infection caused by the herpes simplex virus. It is... more...

Aliases & Classifications for Genital Herpes

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


Aliases & Descriptions:

genital herpes 8 10 44 33 60
other genital herpes 8 60
genital herpes unspecified 8
genital herpes simplex nos 8
genital herpes simplex 8
virus-genital herpes 8
herpes genitalis 8
herpes genitalia 8
venereal herpes 8


External Ids:

Disease Ontology8 DOID:8704
ICD9CM27 054.1, 054.10
NCIt39 C14364
MeSH34 D006558

Related Diseases for Genital Herpes

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Genital Herpes:



Diseases related to genital herpes

Clinical Features for Genital Herpes

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Sources:
8Disease Ontology
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Symptoms:

8
  • swollen gl
  • fever
  • sores

Drugs & Therapeutics for Genital Herpes

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Genital Herpes

Drug clinical trials:

Search ClinicalTrials for Genital Herpes

Search NIH Clinical Center for Genital Herpes

Search CenterWatch for Genital Herpes

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Genital Herpes

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Anatomical Context for Genital Herpes

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Genital Herpes:

32
Testes, T cells, Nk cells, B cells, Skin, Cervix, Myeloid

FMA organs/tissues related to Genital Herpes:

14
Rectum, Genital system

Animal Models for Genital Herpes or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Genital Herpes:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.6CCL3, TLR2, APOE, HLA-B, ZBTB32, TBX21
2MP:00053878.1DARC, CCL5, CCL3, TLR2, APOE, HLA-B

Publications for Genital Herpes

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50PubMed
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Articles related to Genital Herpes:

(show top 50)    (show all 523)
idTitleAuthorsYear
1
Rapid localized spread and immunologic containment define Herpes simplex virus-2 reactivation in the human genital tract. (23606943)
2013
2
Vaxfectin-adjuvanted plasmid DNA vaccine improves protection and immunogenicity in a murine model of genital herpes infection. (22398318)
2012
3
Genital chlamydia, genital herpes, Trichomonas vaginalis and gonorrhea prevalence, and risk factors among nearly 70,000 randomly selected women in 4 Nordic countries. (21844702)
2011
4
Diversity in CD8(+) T cell function and epitope breadth among persons with genital herpes. (20635156)
2010
5
Valacyclovir-induced psychosis and manic symptoms in an adolescent young woman with genital herpes simplex. (19567772)
2009
6
Potent adjuvant activity of cationic liposome-DNA complexes for genital herpes vaccines. (19279167)
2009
7
An immunomodulating dipeptide, SCV-07, is a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2). (18619817)
2008
8
Genital herpes: gynaecological aspects. (18430386)
2008
9
Chemokines and Chemokine Receptors Critical to Host Resistance following Genital Herpes Simplex Virus Type 2 (HSV-2) Infection. (19043604)
2008
10
Has episodic treatment of recurrent genital herpes come of age? (17623498)
2007
11
Performance of focus ELISA tests for HSV-1 and HSV-2 antibodies among university students with no history of genital herpes. (17457239)
2007
12
Selective defect in plasmacyoid dendritic cell function in a patient with AIDS-associated atypical genital herpes simplex vegetans treated with imiquimod. (17205432)
2007
13
High incidence of genotypic variance between sequential herpes simplex virus type 2 isolates from HIV-1-seropositive patients with recurrent genital herpes. (16991086)
2006
14
Subtly impaired humoral immunity predisposes to frequently recurring genital herpes simplex virus type 2 infection and herpetic neuralgia. (16897653)
2006
15
Effect of valacyclovir on viral shedding in immunocompetent patients with recurrent herpes simplex virus 2 genital herpes: a US-based randomized, double-blind, placebo-controlled clinical trial. (17036557)
2006
16
Chronic hypertrophic acyclovir-resistant genital herpes treated with topical cidofovir and with topical foscarnet at recurrence in an HIV-positive man. (16898926)
2006
17
Comparative efficacy of famciclovir and valacyclovir for suppression of recurrent genital herpes and viral shedding. (16540883)
2006
18
Diversity of the CD8+ T-cell response to herpes simplex virus type 2 proteins among persons with genital herpes. (16699031)
2006
19
Validation of the genital herpes treatment satisfaction questionnaire (GHerpTSQ) in status and change versions. (16900284)
2006
20
Genital herpes. (17151051)
2006
21
Virological, serological and epidemiological study of 255 consecutive cases of genital herpes in a sexually transmitted disease clinic of Paris (France): a prospective study. (16409679)
2006
22
Genital herpes vaccines--cause for cautious optimism. (16607967)
2006
23
Effect of Huangbai Liquid on expression of human beta-defensin-2 mRNA in skin lesions of patients with recurrent genital herpes]. (17205827)
2006
24
Genital herpes. (16620476)
2005
25
Health related quality of life in genital herpes: a pilot comparison of measures. (15923300)
2005
26
Genital herpes: a review. (16273819)
2005
27
Changing epidemiology of genital herpes simplex virus infection in Melbourne, Australia, between 1980 and 2003. (15295125)
2004
28
Genital herpes in a sexually-transmitted infection clinic in Singapore: a 1-year retrospective study. (15098634)
2004
29
Once-daily valacyclovir to reduce the risk of transmission of genital herpes. (14702423)
2004
30
Management of genital herpes during pregnancy: the French experience. (15955268)
2004
31
Genital herpes and human immunodeficiency virus: double trouble. (15356938)
2004
32
Study of knowledge of genital herpes infection and attitudes to testing for genital herpes among antenatal clinic attendees. (14717310)
2003
33
Primary genital herpes simplex infection associated with Jewish ritual circumcision. (14689764)
2003
34
Patients' preference of valacyclovir once-daily suppressive therapy versus twice-daily episodic therapy for recurrent genital herpes: a randomized study. (12616141)
2003
35
Progress in meeting today's demands in genital herpes: an overview of current management. (12353187)
2002
36
Genital herpes simplex virus infection in the adolescent: special considerations for management. (11994034)
2002
37
Critical involvement of CD40 in protection against herpes simplex virus infection in a murine model of genital herpes. (11855631)
2002
38
Genital herpes. An approach for general practitioners in Australia. (12402701)
2002
39
CD8 CTL from genital herpes simplex lesions: recognition of viral tegument and immediate early proteins and lysis of infected cutaneous cells. (11238653)
2001
40
Management of genital herpes in HIV-infected patients. (11867017)
2001
41
The importance of diagnosing genital herpes. (11160031)
2001
42
Protective vaccination against genital herpes simplex virus type 2 (HSV-2) infection in mice is associated with a rapid induction of local IFN-gamma-dependent RANTES production following a vaginal viral challenge. (11775012)
2001
43
Most Americans are not concerned with contracting genital herpes: survey. (11917791)
2001
44
JAMA patient page. Genital herpes. (11440015)
2001
45
Premarket evaluation of the POCkit HSV-2 type-specific serologic test in culture-documented cases of genital herpes simplex virus type 2 [see comment]. (10821598)
2000
46
Increasing prevalence of genital herpes in developing countries: implications for heterosexual HIV transmission and STI control programmes. (10754939)
1999
47
British Co-operative Clinical Group national survey on diagnostic issues surrounding genital herpes. MSSVD Special Interest Group on Genital Herpes and the British Co-operative Clinical Group. (10754945)
1999
48
High frequency of CD8+ cytotoxic T-lymphocyte precursors specific for herpes simplex viruses in persons with genital herpes. (8892947)
1996
49
Placebo-controlled trial of vaccination with recombinant glycoprotein D of herpes simplex virus type 2 for immunotherapy of genital herpes. (7911177)
1994
50
Psychological investigation of genital herpes recurrence: prospective assessment and cognitive-behavioral intervention for a chronic physical disorder. (3383831)
1988

Genetic Variations for Genital Herpes

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Expression for genes affiliated with Genital Herpes

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Genital Herpes

Search GEO for disease gene expression data for Genital Herpes.

Pathways for genes affiliated with Genital Herpes

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Sources:
29KEGG, 12EMD Millipore, 37NCBI BioSystems Database
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Pathways related to Genital Herpes according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3TLR2
2
Hide members
9.7IL4, TBX21, CCL3
3
Hide members
9.3NXF1, IL4, HLA-B, TLR2, CCL5

Compounds for genes affiliated with Genital Herpes

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Genital Herpes according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
1endotoxin4410.7DEFB4A
2gm-csf44 2811.7CCL5
3cycloheximide4410.6TLR2
4anaphylatoxin4410.4IL4, CCL5
5h2o24410.3CCL3
6ivermectin44 1111.3CCL5, IL4
7donepezil44 11 2412.2IL4, APOE
8amphotericin b4410.2IL4, TLR2, CCL5
9dexamethasone44 49 28 1113.2CCL5, TLR2, DEFB4A
10hbd24410.2DEFB4A, TLR2
11mip 1alpha4410.1IL4, CCL3, CCL5
12pranlukast44 28 1112.1IL4, CCL5
13methacholine44 1111.0IL4, CCL3, CCL5
14tarc4410.0IL4, CCL3, CCL5
15mcp 14410.0CCL3, CCL5
16ccl344 2811.0TLR2, CCL3, CCL5
17ccl444 2811.0CCL5, CCL3, TLR2
18pdtc4410.0IL4, CCL3, CCL5
19ribavirin44 49 1112.0CCL3, HLA-B, IL4
20peptidoglycan44 2810.9DEFB4A, TLR2, CCL3, CCL5
21bleomycin44 1110.9CCL3, APOE, IL4
22poly(i-c)449.9IL4, TLR2, CCL3, CCL5
23sp 60012544 5910.9DEFB4A, TLR2, CCL3, CCL5
24lipoteichoic acid449.9CCL3, TLR2, HLA-B, DEFB4A
25leukotriene b444 59 2411.9TLR2, CCL3, CCL5
26il 10449.9CCL5, CCL3, TLR2, IL4
27ritonavir44 49 1111.9CCL5, CCL3, APOE, IL4
28polyinosinic-polycytidylic acid449.9CCL3, TLR2, HLA-B, IL4
29ionomycin449.8IL4, TLR2, CCL3, CCL5
30latex449.8CCL3, TLR2, HLA-B
31glatiramer acetate44 1110.8IL4, CCL5
32ribonucleic acid449.7CCL5, CCL3, TLR2, HLA-B
33sb 20358044 5910.7CCL5, CCL3, TLR2, DEFB4A, IL4
34homocysteine44 2410.7APOE, CCL3, CCL5
35histamine44 28 2411.7CCL5, CCL3, TLR2, DEFB4A, IL4
36simvastatin44 49 59 28 11 2414.7IL4, APOE, TLR2, CCL3, CCL5
37tacrolimus44 49 1111.6CCL5, CCL3, TLR2, HLA-B, IL4
38rantes449.5DARC, IL4, DEFB4A, HLA-B, TLR2, CCL3
39pd 98,059449.4CCL5, CCL3, TLR2, DEFB4A
40cyclosporin a44 28 5911.4CCL5, CCL3, TLR2, APOE, HLA-B, IL4
41cholesterol44 28 11 2412.3CCL5, CCL3, TLR2, APOE, HLA-B
42cysteine449.2CCL5, CCL3, TLR2, APOE, DEFB4A, NFU1

GO Terms for genes affiliated with Genital Herpes

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16Gene Ontology
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Biological processes related to Genital Herpes according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of isotype switching to IgG isotypesGO:04830410.2IL4, TBX21
2positive regulation of natural killer cell chemotaxisGO:200050310.1CCL3, CCL5
3eosinophil chemotaxisGO:04824510.0CCL5, CCL3
4lipopolysaccharide-mediated signaling pathwayGO:0316639.9TLR2, CCL3, CCL5
5negative regulation by host of viral transcriptionGO:0439229.9CCL3, CCL5
6monocyte chemotaxisGO:0025489.9CCL3, CCL5
7cellular response to interleukin-1GO:0713479.9CCL5, CCL3, APOE
8macrophage chemotaxisGO:0482469.8CCL5, CCL3
9cellular calcium ion homeostasisGO:0068749.7APOE, CCL3, CCL5
10chemotaxisGO:0069359.7IL4, DEFB4A, CCL3, CCL5
11inflammatory responseGO:0069549.2DARC, TLR2, CCL3, CCL5

Molecular functions related to Genital Herpes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CCR1 chemokine receptor bindingGO:0317269.9CCL3, CCL5
2CCR5 chemokine receptor bindingGO:0317309.8CCL3, CCL5
3phospholipase activator activityGO:0160049.6CCL3, CCL5

Products for genes affiliated with Genital Herpes

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Genital Herpes

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet