MCID: GNT003
MIFTS: 68

Genital Herpes malady

Infectious diseases, Reproductive diseases categories

Summaries for Genital Herpes

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Sources:
9Disease Ontology, 35MedlinePlus, 4CDC, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Genital herpes is a sexually transmitted disease (std) caused by a herpes simplex virus (hsv). it can cause sores on your genital or rectal area, buttocks, and thighs. you can get it from having sex, even oral sex. the virus can spread even when sores are not present. mothers can also infect their babies during childbirth. symptoms of herpes are called outbreaks. you usually get sores near the area where the virus has entered the body. they turn into blisters, become itchy and painful, and then heal. sometimes people do not know they have herpes because they have no symptoms or very mild symptoms. the virus can be more serious in newborn babies or in people with weak immune systems. most people have outbreaks several times a year. over time, you get them less often and the symptoms become milder. the virus stays in your body for life. medicines do not cure genital herpes, but they can help your body fight the virus. this can help lessen symptoms, decrease outbreaks, and lower the risk of passing the virus to others. correct usage of latex condoms can reduce, but not eliminate, the risk of catching or spreading herpes. nih: national institute of allergy and infectious diseases

MalaCards: Genital Herpes, also known as other genital herpes, is related to herpes simplex and keratitis, and has symptoms including swollen gl, sores and fever. An important gene associated with Genital Herpes is DARC (Duffy blood group, atypical chemokine receptor), and among its related pathways are Folate Metabolism and Lymphocyte Signaling. The drugs acyclovir and interferon alfa-2b and the compounds hbd2 and amphotericin b have been mentioned in the context of this disorder. Affiliated tissues include rectum, genital system and testes, and related mouse phenotypes are renal/urinary system and digestive/alimentary.

Disease Ontology:9 A herpes simplex that results in infection located in genital system, or located in rectum, has material basis in human herpesvirus 1 or has material basis in human herpesvirus 2, which is transmitted by sexual contact. the infection has symptom sores, has symptom fever, and has symptom swollen glands.

CDC:4 Genital herpes is a common STD, and most people with genital herpes infection do not know they have it.

Wikipedia:66 Herpes genitalis (or genital herpes) is a genital infection caused by the herpes simplex virus. A 1998... more...

Aliases & Classifications for Genital Herpes

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 35MedlinePlus, 63UMLS, 59SNOMED-CT, 36MeSH, 28ICD9CM, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Reproductive diseases


Aliases & Descriptions:

genital herpes 9 11 46 35 63
other genital herpes 9 63
genital herpes unspecified 9
genital herpes simplex nos 9
genital herpes simplex 9
virus-genital herpes 9
herpes genitalia 9
herpes genitalis 9
venereal herpes 9


External Ids:

Disease Ontology9 DOID:8704
MeSH36 D006558
ICD9CM28 054.1, 054.10
NCIt41 C14364

Related Diseases for Genital Herpes

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Genital Herpes via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 92)
idRelated DiseaseScoreTop Affiliating Genes
1herpes simplex31.5IFNA1, CCL5, GGH, DARC, HLA-B, TLR2
2keratitis30.1DARC, TLR2
3leukemia30.0GGH, CCL3, HLA-B, IFNA1, IL4, TLR2
4encephalitis29.9IFNA1, DARC, CCL3, CCL5, HLA-B, TLR2
5blindness10.5
6vaginitis10.3
7neonatal herpes10.3
8herpes zoster10.3
9gonorrhea10.2
10chancroid10.2
11chronic lymphocytic leukemia10.2
12meningitis10.2
13syphilis10.2
14urticaria10.2
15hiv-110.2
16folliculitis10.1DEFB4A
17sinusitis10.1DEFB4A
18meningoencephalitis10.1CCL5
19rhinotracheitis10.1DARC, PI3
20lichen planus10.1DEFB4A
21extrinsic allergic alveolitis10.1CCL3, PI3
22aspergillosis10.1CCL3, TLR2
23leprosy10.1TLR2
24mast-cell leukemia10.1CCL5, CCL3
25lepromatous leprosy10.1TLR2, IL4
26bacterial meningitis10.1CCL3, TLR2
27alcoholic hepatitis10.1CCL5, CCL3
28dengue disease10.1CCL5, CCL3
29vernal keratoconjunctivitis10.1CCL5, IL4
30lyme disease10.1CCL3, TLR2
31pulmonary eosinophilia10.1IL4, CCL3
32human immunodeficiency virus infectious disease10.1ATAD2, CCL3
33idiopathic myopathy10.0CCL5, HLA-B
34periodontal disease10.0DEFB4A, TLR2, CCL3
35sarcoidosis10.0DEFB4A, CCL5, CCL3
36atopic dermatitis10.0DEFB4A, TLR2, IL4
37bronchiolitis10.0CCL3, CCL5
38atopy10.0IL4, CCL5, TLR2
39interstitial lung disease10.0CCL3, CCL5
40periapical granuloma10.0CCL3, CCL5, IL4
41allergic rhinitis10.0CCL5, IL4, TLR2
42diabetic ketoacidosis10.0
43urethritis10.0
44pharyngitis10.0
45herpetic whitlow10.0
46primary syphilis10.0
47erythema multiforme10.0
48eczema herpeticum10.0
49hailey-hailey disease10.0
50lymphogranuloma venereum10.0

Graphical network of the top 20 diseases related to Genital Herpes:



Diseases related to genital herpes

Symptoms for Genital Herpes

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Sources:
9Disease Ontology
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Symptoms:

9
  • swollen gl
  • sores
  • fever

Drugs & Therapeutics for Genital Herpes

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Genital Herpes

Drug clinical trials:

Search ClinicalTrials for Genital Herpes

Search NIH Clinical Center for Genital Herpes

Search CenterWatch for Genital Herpes

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Genital Herpes

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Anatomical Context for Genital Herpes

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Sources:
34MalaCards, 15FMA
See all sources

MalaCards organs/tissues related to Genital Herpes:

34
Testes, T cells, B cells, Skin, Nk cells, Myeloid, Cervix

FMA organs/tissues related to Genital Herpes:

15
Rectum, Genital system

Animal Models for Genital Herpes or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Genital Herpes:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.8IL4, NXF1, APOE, T, TLR2
2MP:00053818.4TBX21, TLR2, T, APOE, CCL3, IL4
3MP:00053877.7DARC, HLA-B, TLR2, APOE, CCL3, CCL5
4MP:00053977.6HLA-B, TLR2, APOE, CCL3, CCL5, IL4
5MP:00036317.3HLA-B, TLR2, T, APOE, NXF1, CCL3

Publications for Genital Herpes

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Sources:
53PubMed
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Articles related to Genital Herpes:

(show top 50)    (show all 504)
idTitleAuthorsYear
1
Vaxfectin-adjuvanted plasmid DNA vaccine improves protection and immunogenicity in a murine model of genital herpes infection. (22398318)
2012
2
Looking for an asymptomatic infection: usefulness of screening for Chlamydia trachomatis and genital herpes. (23007249)
2012
3
Using centralized laboratory data to monitor trends in herpes simplex virus type 1 and 2 infection in British Columbia and the changing etiology of genital herpes. (21714324)
2011
4
Clarification in law is sought after man is jailed for infecting partner with genital herpes. (21859791)
2011
5
Effect of ASP2151, a herpesvirus helicase-primase inhibitor, in a guinea pig model of genital herpes. (21869749)
2011
6
Suppressive valacyclovir therapy to reduce genital herpes transmission: good public health policy? (19753286)
2009
7
New concepts in understanding genital herpes. (19857385)
2009
8
Valacyclovir to reduce transmission of genital herpes simplex virus infection. (19239344)
2009
9
Comparison of nested-polymerase chain reaction and virus culture for the diagnosis of genital herpes simplex virus infection. (18581019)
2008
10
Is suspicion of genital herpes infection associated with avoiding sex? A clinic-based study. (18771644)
2008
11
Knowledge about genital herpes amongst first time attenders at a department of genitourinary medicine. (18422207)
2008
12
Famciclovir treatment options for patients with frequent outbreaks of recurrent genital herpes: the RELIEF trial. (18621575)
2008
13
Managing genital herpes infections in pregnancy. (17375803)
2007
14
Susceptibility of CCR5-deficient mice to genital herpes simplex virus type 2 is linked to NK cell mobilization. (17267483)
2007
15
Genital herpes and its management. (17510153)
2007
16
Suppressive therapy with valacyclovir in early genital herpes: a pilot study of clinical efficacy and herpes-related quality of life. (17065847)
2007
17
Genital herpes in Africa: time to rethink treatment. (18156037)
2007
18
Single-day therapy: an expert opinion on a recent development for the episodic treatment of recurrent genital herpes. (16957911)
2007
19
Adolescents anticipated experience of screening for genital herpes. (16895656)
2006
20
Imiquimod 5% cream for the treatment of recurrent, acyclovir-resistant genital herpes. (16421805)
2006
21
Genital herpes complicating pregnancy. (16507951)
2006
22
National survey of diagnostic services for genital herpes. (16061538)
2005
23
Genital herpes. (16620476)
2005
24
Counseling the patient who has genital herpes or genital human papillomavirus infection. (15963883)
2005
25
Neurokinin 1 receptor signaling affects the local innate immune defense against genital herpes virus infection. (16272337)
2005
26
Genital herpes: common but misunderstood. Don't assume that genital herpes isn't your concern. (16435436)
2005
27
Epidemiology of genital herpes simplex virus infections in a community-based sample in France: results of the HERPIMAX study. (16041253)
2005
28
Genital herpes. (15652098)
2004
29
Expert commentary: genital herpes transmission. (15955269)
2004
30
The theoretical basis of stigma as applied to genital herpes. (15115630)
2004
31
Changing epidemiology of genital herpes simplex virus infection in Melbourne, Australia, between 1980 and 2003. (15295125)
2004
32
Oral famciclovir for the suppression of recurrent genital herpes: the combined data from two randomized controlled trials. (15931690)
2003
33
Study of knowledge of genital herpes infection and attitudes to testing for genital herpes among antenatal clinic attendees. (14717310)
2003
34
Predominance of herpes simplex virus type 1 from patients with genital herpes in Nova Scotia. (18159431)
2003
35
Progress in meeting today's demands in genital herpes: an overview of current management. (12353187)
2002
36
Genital herpes. (11991914)
2002
37
Aborted genital herpes simplex virus lesions: findings from a randomised controlled trial with valaciclovir. (12473805)
2002
38
Psychosocial outcomes in individuals living with genital herpes. (12353728)
2002
39
Imiquimod and genital herpes. (11939822)
2002
40
The ratio of cytokine levels in genital herpes during various phases of infection. (11687847)
2001
41
Patients' perspectives on the burden of recurrent genital herpes. (11564330)
2001
42
Dendritic cell vaccination protects mice against lethality caused by genital herpes simplex virus type 2 infection. (11334992)
2001
43
Seroprevalence of herpes simplex virus type 1 and type 2 in selected German populations-relevance for the incidence of genital herpes. (10797375)
2000
44
Improving the care of patients with genital herpes. (10977846)
2000
45
Cooperative agreements for strategies to prevent genital herpes infections: building a national prevention program, notice of availability of funds. Centers for Disease Control and Prevention. (10558529)
1999
46
Medication tames genital herpes. (14612772)
1999
47
Quality of life and use of health care among people with genital herpes in France. (10494718)
1999
48
Valaciclovir: new indications. In genital herpes: simpler administration. (10557565)
1999
49
Undocumented history of maternal genital herpes followed by neonatal herpes meningitis. (8064427)
1994
50
Psychological investigation of genital herpes recurrence: prospective assessment and cognitive-behavioral intervention for a chronic physical disorder. (3383831)
1988

Variations for Genital Herpes

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Expression for genes affiliated with Genital Herpes

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Genital Herpes

Search GEO for disease gene expression data for Genital Herpes.

Pathways for genes affiliated with Genital Herpes

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Sources:
51PathCards, 39NCBI BioSystems Database, 5Cell Signaling Technology, 31KEGG, 61Thomson Reuters, 55R&D Systems, 56Reactome
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Pathways related to Genital Herpes according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Vitamin B12 Metabolism39
9.9CCL5, APOE
29.7CCL5, IL4, TBX21
3
Show member pathways
9.7TBX21, IL4, TLR2
4
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
9.7IL4, TLR2, DEFB4A
5
Show member pathways
9.2CCL5, CCL3, DARC
6
Show member pathways
Immune response IL 12 induced IFN gamma production61
9.1CCL3, IL4, TBX21
79.1CCL5, CCL3, TLR2
8
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
8.6TLR2, CCL3, CCL5, IFNA1
9
Show member pathways
8.2IL4, IFNA1, CCL5, NXF1, TLR2, HLA-B

Compounds for genes affiliated with Genital Herpes

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Sources:
46Novoseek, 30IUPHAR, 12DrugBank, 25HMDB, 62Tocris Bioscience, 52PharmGKB, 3BitterDB
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Compounds related to Genital Herpes according to GeneCards/GeneDecks:

(show top 50)    (show all 85)
idCompoundScoreTop Affiliating Genes
1hbd24610.2DEFB4A, PI3, TLR2
2amphotericin b4610.0IL4, CCL5, TLR2
3betaseron469.9IL4, IFNA1
4loxoribine46 3010.9IFNA1, TLR2
5glatiramer acetate46 1210.8CCL5, IFNA1, IL4
6ursodeoxycholic acid46 25 1211.6IFNA1, APOE, HLA-B
7mip 1alpha469.5IL4, CCL5, CCL3
8anaphylatoxin469.4CCL3, CCL5, IL4
9gm-csf46 3010.4IL4, CCL5, CCL3
10resiquimod46 6210.4IFNA1, TLR2
11methacholine46 52 1211.4CCL3, CCL5, IL4
12ccl446 3010.3TLR2, CCL3, CCL5
13tarc469.3IL4, CCL5, CCL3
14chloroquine46 3 52 30 1213.3IL4, IFNA1, APOE
15peptidoglycan46 3010.3CCL5, CCL3, TLR2, DEFB4A
16sp 60012546 6210.2DEFB4A, TLR2, CCL3, CCL5
17lipoteichoic acid469.2DEFB4A, HLA-B, TLR2, CCL3
18il 10469.2IL4, CCL5, CCL3, TLR2
19ritonavir46 52 1211.2APOE, CCL3, CCL5, IL4
20heparan sulfate46 2510.2TLR2, CCL3, CCL5, GGH
21ionomycin469.1IL4, CCL5, CCL3, TLR2
22pdtc469.1IL4, CCL5, CCL3
23ccl346 3010.0TLR2, CCL3, CCL5, IFNA1
24neopterin469.0IL4, IFNA1, CCL3
25endotoxin469.0DEFB4A, HLA-B, TLR2, CCL3, CCL5
26ribonucleic acid468.9HLA-B, TLR2, CCL3, CCL5
27simvastatin46 52 62 30 25 1213.9TLR2, APOE, CCL3, CCL5, IL4
28ribavirin46 52 1210.9HLA-B, CCL3, IFNA1, IL4
29bleomycin46 129.9IL4, IFNA1, CCL3, APOE
30indomethacin46 30 62 1211.8APOE, CCL3, CCL5, IL4
31lipid468.8DARC, DEFB4A, PI3, HLA-B, TLR2, APOE
32sb 20358046 629.8DEFB4A, PI3, TLR2, CCL3, CCL5, IL4
33histamine46 30 2510.8DEFB4A, PI3, TLR2, CCL3, CCL5, IL4
34pge2468.7HLA-B, TLR2, CCL3, CCL5, IL4
35poly(i-c)468.7TLR2, CCL3, CCL5, IFNA1, IL4
36polyinosinic-polycytidylic acid468.6HLA-B, TLR2, CCL3, IFNA1, IL4
37actinomycin d468.6TLR2, APOE, CCL3, IFNA1, IL4
38h2o2468.5HLA-B, TLR2, APOE, CCL3, CCL5
39tyrosine468.5DARC, DEFB4A, PI3, HLA-B, TLR2, CCL5
40tacrolimus46 52 1210.4HLA-B, TLR2, CCL3, CCL5, IFNA1, IL4
41cholesterol46 30 25 1211.3HLA-B, TLR2, APOE, CCL3, CCL5
42cycloheximide468.3TLR2, APOE, CCL3, CCL5, IFNA1, IL4
43vegf468.3TLR2, APOE, CCL3, CCL5, IFNA1, IL4
44alanine468.2DARC, TLR2, APOE, CCL3, CCL5, IFNA1
45retinoic acid46 259.2DEFB4A, PI3, HLA-B, TLR2, CCL3, CCL5
46cysteine468.0DEFB4A, PI3, TLR2, APOE, CCL3, CCL5
47rantes468.0IL4, DARC, DEFB4A, HLA-B, TLR2, CCL3
48dexamethasone46 52 30 1210.9DEFB4A, PI3, HLA-B, TLR2, CCL3, CCL5
49cyclosporin a46 30 629.9PI3, HLA-B, TLR2, APOE, CCL3, CCL5
50serine467.5PI3, HLA-B, TLR2, APOE, NXF1, CCL3

GO Terms for genes affiliated with Genital Herpes

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17Gene Ontology
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Cellular components related to Genital Herpes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5GGH, IL4, CCL5, CCL3, APOE

Biological processes related to Genital Herpes according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of isotype switching to IgG isotypesGO:04830410.3IL4, TBX21
2positive regulation of interleukin-10 productionGO:03273310.0TLR2, IL4
3response to insulinGO:03286810.0GGH, APOE, TLR2
4response to ethanolGO:0454719.9GGH, IL4, APOE
5chemokine-mediated signaling pathwayGO:0700989.7CCL5, DARC
6positive regulation of natural killer cell chemotaxisGO:20005039.7CCL5, CCL3
7eosinophil chemotaxisGO:0482459.7CCL3, CCL5
8negative regulation by host of viral transcriptionGO:0439229.6CCL3, CCL5
9macrophage chemotaxisGO:0482469.6CCL5, CCL3
10immune responseGO:0069559.6IL4, TLR2, HLA-B, DEFB4A
11monocyte chemotaxisGO:0025489.6CCL5, CCL3
12negative regulation of osteoclast differentiationGO:0456719.5IL4, CCL3
13cellular response to interferon-gammaGO:0713469.5CCL5, CCL3
14lipopolysaccharide-mediated signaling pathwayGO:0316639.4CCL5, CCL3, TLR2
15response to toxic substanceGO:0096369.4CCL5, CCL3, TLR2
16cellular response to interleukin-1GO:0713479.4APOE, CCL3, CCL5
17positive regulation of calcium ion transportGO:0519289.4CCL3, CCL5
18protein kinase B signalingGO:0434919.4CCL5, CCL3
19cellular calcium ion homeostasisGO:0068749.4CCL5, CCL3, APOE
20positive chemotaxisGO:0509189.3CCL5, CCL3
21chemotaxisGO:0069359.2IL4, CCL5, CCL3, DEFB4A
22inflammatory responseGO:0069549.2DARC, TLR2, CCL3, CCL5

Molecular functions related to Genital Herpes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phospholipase activator activityGO:0160049.4CCL5, CCL3
2chemoattractant activityGO:0420569.4CCL5, CCL3
3CCR1 chemokine receptor bindingGO:0317269.3CCL5, CCL3
4CCR5 chemokine receptor bindingGO:0317309.1CCL5, CCL3

Products for genes affiliated with Genital Herpes

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Genital Herpes

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet