MCID: GNT003
MIFTS: 59

Genital Herpes malady

Reproductive category

Summaries for Genital Herpes

Sources:
8Disease Ontology, 34MedlinePlus, 3CDC, 64Wikipedia, 33MalaCards
See all sources

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MedlinePlus:34 Genital herpes is a sexually transmitted disease (std) caused by a herpes simplex virus (hsv). it can cause sores on your genital or rectal area, buttocks, and thighs. you can get it from having sex, even oral sex. the virus can spread even when sores are not present. mothers can also infect their babies during childbirth. symptoms of herpes are called outbreaks. you usually get sores near the area where the virus has entered the body. they turn into blisters, become itchy and painful, and then heal. sometimes people do not know they have herpes because they have no symptoms or very mild symptoms. the virus can be more serious in newborn babies or in people with weak immune systems. most people have outbreaks several times a year. over time, you get them less often and the symptoms become milder. the virus stays in your body for life. medicines do not cure genital herpes, but they can help your body fight the virus. this can help lessen symptoms, decrease outbreaks, and lower the risk of passing the virus to others. correct usage of latex condoms can reduce, but not eliminate, the risk of catching or spreading herpes. nih: national institute of allergy and infectious diseases

MalaCards: Genital Herpes, also known as other genital herpes, is related to neonatal herpes and herpes zoster, and has symptoms including sores, fever and swollen gl. An important gene associated with Genital Herpes is DARC (Duffy blood group, atypical chemokine receptor), and among its related pathways are Rheumatoid arthritis and Immune response IL-12-induced IFN-gamma production. The drugs interferon alfa-2b and acyclovir and the compounds endotoxin and gm-csf have been mentioned in the context of this disorder. Affiliated tissues include genital system, rectum and skin, and related mouse phenotypes are hematopoietic system and immune system.

Disease Ontology:8 A herpes simplex that results in infection located in genital system, or located in rectum, has material basis in human herpesvirus 1 or has material basis in human herpesvirus 2, which is transmitted by sexual contact. the infection has symptom sores, has symptom fever, and has symptom swollen glands.

CDC:3 Genital herpes is a common STD, and most people with genital herpes infection do not know they have it.

Wikipedia:64 Herpes genitalis (or genital herpes) refers to a genital infection by Herpes simplex virus, the most... more...

Aliases & Classifications for Genital Herpes

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 27ICD9CM, 40NCIt, 35MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive


Aliases & Descriptions:

genital herpes 8 10 45 34 61
other genital herpes 8 61
genital herpes unspecified 8
genital herpes simplex nos 8
genital herpes simplex 8
virus-genital herpes 8
herpes genitalis 8
herpes genitalia 8
venereal herpes 8


External Ids:

Disease Ontology8 DOID:8704
ICD9CM27 054.1, 054.10
NCIt40 C14364
MeSH35 D006558

Related Diseases for Genital Herpes

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Genital Herpes:



Diseases related to genital herpes

Clinical Features for Genital Herpes

Sources:
8Disease Ontology
See all sources


Symptoms:

8
  • sores
  • fever
  • swollen gl

Drugs & Therapeutics for Genital Herpes

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Genital Herpes

Drug clinical trials:

Search ClinicalTrials for Genital Herpes

Search NIH Clinical Center for Genital Herpes

Search CenterWatch for Genital Herpes

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Genital Herpes

Anatomical Context for Genital Herpes

Sources:
14FMA, 33MalaCards
See all sources

MalaCards organs/tissues related to Genital Herpes:

33
Skin, Cervix, Myeloid, Nk cells, T cells, B cells

FMA organs/tissues related to Genital Herpes:

14
Genital system, Rectum

Animal Models for Genital Herpes or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Genital Herpes:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.6CCL3, TLR2, APOE, HLA-B, ZBTB32, TBX21
2MP:00053878.1DARC, CCL5, CCL3, TLR2, APOE, HLA-B

Publications for Genital Herpes

Sources:
51PubMed
See all sources

Articles related to Genital Herpes:

(show top 50)    (show all 524)
idTitleAuthorsYear
1
Mimicking herpes simplex virus 1 and herpes simplex virus 2 mucosal behavior in a well characterized human genital organ culture. (24436451)
2014
2
Guidance on management of asymptomatic neonates born to women with active genital herpes lesions. (23378604)
2013
3
Epidemiological impact of a genital herpes type 2 vaccine for young females. (23071536)
2012
4
Clarification in law is sought after man is jailed for infecting partner with genital herpes. (21859791)
2011
5
The psychological impact of genital herpes stigma. (20656766)
2011
6
Valacyclovir to reduce transmission of genital herpes simplex virus infection. (19239344)
2009
7
Genital herpes education and counselling: testing a one-page 'FAQ' intervention. (19306603)
2009
8
One-day regimen of valacyclovir for treatment of recurrent genital herpes simplex virus 2 infection. (18362859)
2008
9
An international, randomized, double-blind, placebo-controlled, study of valacyclovir for the suppression of herpes simplex virus type 2 genital herpes in newly diagnosed patients. (18461016)
2008
10
Genital herpes has played a more important role than any other sexually transmitted infection in driving HIV prevalence in Africa. (18493617)
2008
11
Treatment to prevent recurrent genital herpes. (18192785)
2008
12
No association between maternal recurrent genital herpes in pregnancy and higher risk for congenital abnormalities. (18307068)
2008
13
Associated cytologic findings on pap tests from patients with genital herpes: a retrospective cohort analysis in 82 cases over 11 years. (18702377)
2008
14
Case report: herpes meningitis complicating genital herpes presenting as anal fissure. (17939904)
2007
15
Single-day therapy for recurrent genital herpes. (16901180)
2006
16
A randomized controlled trial of a replication defective (gH deletion) herpes simplex virus vaccine for the treatment of recurrent genital herpes among immunocompetent subjects. (16213066)
2006
17
National survey of diagnostic services for genital herpes. (16061538)
2005
18
Genital herpes. (16135318)
2005
19
Expert commentary: genital herpes transmission. (15955269)
2004
20
The theoretical basis of stigma as applied to genital herpes. (15115630)
2004
21
Antiviral treatment of genital herpes. (15228725)
2004
22
Genotypic analysis of sequential genital herpes simplex virus type 1 (HSV-1) isolates of patients with recurrent HSV-1 associated genital herpes. (15221906)
2004
23
Diagnosis of genital herpes by real time PCR in routine clinical practice. (15459412)
2004
24
Isopentenyl pyrophosphate-reactive Vgamma9Vdelta 2 T helper 1-like cells are the major gammadelta T cell subset recovered from lesions of patients with genital herpes. (15243921)
2004
25
Predictors of herpes simplex virus type 2 antibody positivity among persons with no history of genital herpes. (15502676)
2004
26
Reducing Genital Herpes Transmission Using Antiviral Therapy. (15023274)
2004
27
Oral famciclovir for the suppression of recurrent genital herpes: the combined data from two randomized controlled trials. (15931690)
2003
28
Epidemiology of recurrent genital herpes simplex virus types 1 and 2. (14663120)
2003
29
Vaccine prevents genital herpes in subgroup of women. (12585979)
2003
30
Increasing proportion of herpes simplex virus type 1 as a cause of genital herpes infection in college students. (14520181)
2003
31
Time course of seroconversion by HerpeSelect ELISA after acquisition of genital herpes simplex virus type 1 (HSV-1) or HSV-2. (12671550)
2003
32
Performance of the focus and Kalon enzyme-linked immunosorbent assays for antibodies to herpes simplex virus type 2 glycoprotein G in culture-documented cases of genital herpes. (14605166)
2003
33
Successful use of valciclovir in a case of recurrent urticaria associated with genital herpes. (12473820)
2002
34
Genital herpes simplex virus type 1 infection: new fields for an old acquaintance? (11937764)
2002
35
Management and treatment of genital herpes. A practical approach to patient care. (12418353)
2002
36
Valacyclovir in the treatment of genital herpes and herpes zoster. (11772333)
2002
37
Dendritic cell vaccination protects mice against lethality caused by genital herpes simplex virus type 2 infection. (11334992)
2001
38
Genital herpes may mask underlying neoplasia. (11287706)
2001
39
Does the extract of the plant Echinacea purpurea influence the clinical course of recurrent genital herpes? (11231867)
2001
40
A comparison of topical application of penciclovir 1% cream with acyclovir 3% cream for treatment of genital herpes: a randomized, double-blind, multicentre trial. (10997497)
2000
41
Current diagnostic techniques in genital herpes: their role in controlling the epidemic. (11109508)
2000
42
An annular erythema secondary to primary genital herpes. (10678482)
2000
43
A comparative multi-centre study of the efficacy of propolis, acyclovir and placebo in the treatment of genital herpes (HSV). (10782483)
2000
44
Reactivation of genital herpes simplex virus type 2 infection in asymptomatic seropositive persons. (10727588)
2000
45
Current recommendations for the treatment of genital herpes. (11152015)
2000
46
Valaciclovir: new indications. In genital herpes: simpler administration. (10557565)
1999
47
Management of women with recurrent genital herpes in pregnancy in Australia. (10448344)
1999
48
Genital herpes and diabetic ketoacidosis: a patient report. (10587785)
1999
49
Psychological consequences of genital herpes, an exploratory study with a gonorrhea control-group. (8234590)
1993
50
Treatment with acyclovir of genital herpes simplex virus infection complicated by eczema herpeticum. (6744011)
1984

Genetic Variations for Genital Herpes

Expression for genes affiliated with Genital Herpes

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Genital Herpes

Search GEO for disease gene expression data for Genital Herpes.

Pathways for genes affiliated with Genital Herpes

Sources:
30KEGG, 12EMD Millipore, 38NCBI BioSystems Database
See all sources

Pathways related to Genital Herpes according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3TLR2
2
Hide members
9.7IL4, TBX21, CCL3
3
Hide members
9.3NXF1, IL4, HLA-B, TLR2, CCL5

Compounds for genes affiliated with Genital Herpes

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience
See all sources

Compounds related to Genital Herpes according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
1endotoxin4510.7DEFB4A
2gm-csf45 2911.7CCL5
3cycloheximide4510.6TLR2
4anaphylatoxin4510.4IL4, CCL5
5h2o24510.3CCL3
6ivermectin45 1111.3CCL5, IL4
7donepezil45 11 2412.2IL4, APOE
8amphotericin b4510.2IL4, TLR2, CCL5
9dexamethasone45 50 29 1113.2CCL5, TLR2, DEFB4A
10hbd24510.2DEFB4A, TLR2
11mip 1alpha4510.1IL4, CCL3, CCL5
12pranlukast45 29 1112.1IL4, CCL5
13methacholine45 1111.0IL4, CCL3, CCL5
14tarc4510.0IL4, CCL3, CCL5
15mcp 14510.0CCL3, CCL5
16ccl345 2911.0TLR2, CCL3, CCL5
17ccl445 2911.0CCL5, CCL3, TLR2
18pdtc4510.0IL4, CCL3, CCL5
19ribavirin45 50 1112.0CCL3, HLA-B, IL4
20peptidoglycan45 2910.9DEFB4A, TLR2, CCL3, CCL5
21bleomycin45 1110.9CCL3, APOE, IL4
22poly(i-c)459.9IL4, TLR2, CCL3, CCL5
23sp 60012545 6010.9DEFB4A, TLR2, CCL3, CCL5
24lipoteichoic acid459.9CCL3, TLR2, HLA-B, DEFB4A
25leukotriene b445 60 2411.9TLR2, CCL3, CCL5
26il 10459.9CCL5, CCL3, TLR2, IL4
27ritonavir45 50 1111.9CCL5, CCL3, APOE, IL4
28polyinosinic-polycytidylic acid459.9CCL3, TLR2, HLA-B, IL4
29ionomycin459.8IL4, TLR2, CCL3, CCL5
30latex459.8CCL3, TLR2, HLA-B
31glatiramer acetate45 1110.8IL4, CCL5
32ribonucleic acid459.7CCL5, CCL3, TLR2, HLA-B
33sb 20358045 6010.7CCL5, CCL3, TLR2, DEFB4A, IL4
34homocysteine45 2410.7APOE, CCL3, CCL5
35histamine45 29 2411.7CCL5, CCL3, TLR2, DEFB4A, IL4
36simvastatin45 50 60 29 11 2414.7IL4, APOE, TLR2, CCL3, CCL5
37tacrolimus45 50 1111.6CCL5, CCL3, TLR2, HLA-B, IL4
38rantes459.5DARC, IL4, DEFB4A, HLA-B, TLR2, CCL3
39pd 98,059459.4CCL5, CCL3, TLR2, DEFB4A
40cyclosporin a45 29 6011.4CCL5, CCL3, TLR2, APOE, HLA-B, IL4
41cholesterol45 29 11 2412.3CCL5, CCL3, TLR2, APOE, HLA-B
42cysteine459.2CCL5, CCL3, TLR2, APOE, DEFB4A, NFU1

GO Terms for genes affiliated with Genital Herpes

Sources:
16Gene Ontology
See all sources

Biological processes related to Genital Herpes according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of isotype switching to IgG isotypesGO:04830410.2IL4, TBX21
2positive regulation of natural killer cell chemotaxisGO:200050310.1CCL3, CCL5
3eosinophil chemotaxisGO:04824510.0CCL5, CCL3
4lipopolysaccharide-mediated signaling pathwayGO:0316639.9TLR2, CCL3, CCL5
5negative regulation by host of viral transcriptionGO:0439229.9CCL3, CCL5
6monocyte chemotaxisGO:0025489.9CCL3, CCL5
7cellular response to interleukin-1GO:0713479.9CCL5, CCL3, APOE
8macrophage chemotaxisGO:0482469.8CCL5, CCL3
9cellular calcium ion homeostasisGO:0068749.7APOE, CCL3, CCL5
10chemotaxisGO:0069359.7IL4, DEFB4A, CCL3, CCL5
11inflammatory responseGO:0069549.2DARC, TLR2, CCL3, CCL5

Molecular functions related to Genital Herpes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CCR1 chemokine receptor bindingGO:0317269.9CCL3, CCL5
2CCR5 chemokine receptor bindingGO:0317309.8CCL3, CCL5
3phospholipase activator activityGO:0160049.6CCL3, CCL5

Products for genes affiliated with Genital Herpes

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Genital Herpes

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet