Aliases & Classifications for Genital Herpes

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Genital Herpes, Aliases & Descriptions:

Name: Genital Herpes 9 11 43 32 3 60
Genital Herpes Simplex 9
Virus-Genital Herpes 9
 
Herpes Genitalia 9
Herpes Genitalis 9
Venereal Herpes 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


External Ids:

Disease Ontology9 DOID:8704
NCIt38 C14364
ICD9CM27 054.10, 054.1
MeSH33 D006558

Summaries for Genital Herpes

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MedlinePlus:32 Genital herpes is a sexually transmitted disease (std) caused by a herpes simplex virus (hsv). it can cause sores on your genital or rectal area, buttocks, and thighs. you can get it from having sex, even oral sex. the virus can spread even when sores are not present. mothers can also infect their babies during childbirth. symptoms of herpes are called outbreaks. you usually get sores near the area where the virus has entered the body. they turn into blisters, become itchy and painful, and then heal. sometimes people do not know they have herpes because they have no symptoms or very mild symptoms. the virus can be more serious in newborn babies or in people with weak immune systems. most people have outbreaks several times a year. over time, you get them less often and the symptoms become milder. the virus stays in your body for life. medicines do not cure genital herpes, but they can help your body fight the virus. this can help lessen symptoms, decrease outbreaks, and lower the risk of passing the virus to others. correct usage of latex condoms can reduce, but not eliminate, the risk of catching or spreading herpes. nih: national institute of allergy and infectious diseases

MalaCards based summary: Genital Herpes, also known as genital herpes simplex, is related to herpes simplex and keratitis, and has symptoms including sores, fever and swollen gl. An important gene associated with Genital Herpes is DARC (Duffy blood group, atypical chemokine receptor), and among its related pathways are Folate Metabolism and Lymphocyte Signaling. The drugs interferon alfa-2b and acyclovir and the compounds hbd2 and amphotericin b have been mentioned in the context of this disorder. Affiliated tissues include genital system, rectum and testes, and related mouse phenotypes are renal/urinary system and digestive/alimentary.

Disease Ontology:9 A herpes simplex that results in infection located in genital system, or located in rectum, has material basis in human herpesvirus 1 or has material basis in human herpesvirus 2, which is transmitted by sexual contact. the infection has symptom sores, has symptom fever, and has symptom swollen glands.

Wikipedia:63 Herpes genitalis (or genital herpes) is a genital infection caused by the herpes simplex virus. A 1998... more...

Related Diseases for Genital Herpes

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Diseases related to Genital Herpes via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 94)
idRelated DiseaseScoreTop Affiliating Genes
1herpes simplex31.0DARC, HLA-B, TLR2, CCL5, IFNA1, GGH
2keratitis30.5DARC, TLR2
3leukemia29.3HLA-B, TLR2, CCL3, IFNA1, IL4, GGH
4encephalitis29.3DARC, HLA-B, TLR2, CCL3, CCL5, IFNA1
5blindness10.6
6folliculitis10.6DEFB4A
7sinusitis10.5DEFB4A
8meningoencephalitis10.5CCL5
9rhinotracheitis10.5PI3, DARC
10lichen planus10.4DEFB4A
11acne10.4DEFB4A, TLR2
12vaginitis10.3
13neonatal herpes10.3
14extrinsic allergic alveolitis10.3CCL3, PI3
15aspergillosis10.3TLR2, CCL3
16leprosy10.3TLR2
17systemic mastocytosis10.3CCL3, CCL5
18lepromatous leprosy10.3TLR2, IL4
19hiv-110.3
20herpes zoster10.3
21chancroid10.3
22alcoholic hepatitis10.3CCL3, CCL5
23bacterial meningitis10.3CCL3, TLR2
24dengue disease10.3CCL3, CCL5
25vernal keratoconjunctivitis10.3CCL5, IL4
26lyme disease10.2TLR2, CCL3
27human immunodeficiency virus infectious disease10.2ATAD2, CCL3
28pulmonary eosinophilia10.2IL4, CCL3
29idiopathic myopathy10.2HLA-B, CCL5
30periodontal disease10.2DEFB4A, TLR2, CCL3
31chronic lymphocytic leukemia10.2
32gonorrhea10.2
33lymphogranuloma venereum10.2
34meningitis10.2
35syphilis10.2
36urticaria10.2
37atopic dermatitis10.2DEFB4A, TLR2, IL4
38sarcoidosis 110.2DEFB4A, CCL3, CCL5
39interstitial lung disease10.2CCL5, CCL3
40atopy10.2IL4, CCL5, TLR2
41periapical granuloma10.1CCL3, CCL5, IL4
42bronchiolitis10.1CCL5, CCL3
43allergic rhinitis10.1TLR2, CCL5, IL4
44pulmonary tuberculosis10.1TLR2, CCL3, IL4
45pulmonary sarcoidosis10.1CCL3, CCL5
46skin disease10.1IL4, TLR2, PI3, DEFB4A
47pulmonary disease, chronic obstructive10.1CCL5, CCL3, TLR2, PI3
48relapsing-remitting multiple sclerosis10.1CCL5, IFNA1
49gastritis10.1DEFB4A, TLR2, CCL3, CCL5
50colitis10.1DEFB4A, TLR2, T, IL4

Graphical network of the top 20 diseases related to Genital Herpes:



Diseases related to genital herpes

Symptoms for Genital Herpes

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Symptoms:

 9
  • sores
  • fever
  • swollen gl

Drugs & Therapeutics for Genital Herpes

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Drug clinical trials:

Search ClinicalTrials for Genital Herpes

Search NIH Clinical Center for Genital Herpes

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Genital Herpes

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Anatomical Context for Genital Herpes

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MalaCards organs/tissues related to Genital Herpes:

31
Testes, T cells, Skin, Nk cells, B cells, Cervix, Myeloid

FMA organs/tissues related to Genital Herpes:

14
Genital system, Rectum

Animal Models for Genital Herpes or affiliated genes

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MGI Mouse Phenotypes related to Genital Herpes:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.8IL4, NXF1, APOE, T, TLR2
2MP:00053818.4TBX21, TLR2, T, APOE, CCL3, IL4
3MP:00053877.7DARC, HLA-B, TLR2, APOE, CCL3, CCL5
4MP:00053977.6HLA-B, TLR2, APOE, CCL3, CCL5, IL4
5MP:00036317.3HLA-B, TLR2, T, APOE, NXF1, CCL3

Publications for Genital Herpes

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Articles related to Genital Herpes:

(show top 50)    (show all 525)
idTitleAuthorsYear
1
Chancroid, lymphogranuloma venereum, granuloma inguinale, genital herpes simplex infection, and molluscum contagiosum. (24559566)
2014
2
Status of prophylactic and therapeutic genital herpes vaccines. (24631871)
2014
3
Valaciclovir versus aciclovir for the treatment of primary genital herpes simplex: a cost analysis. (25505043)
2014
4
Vaxfectin-adjuvanted plasmid DNA vaccine improves protection and immunogenicity in a murine model of genital herpes infection. (22398318)
2012
5
Looking for an asymptomatic infection: usefulness of screening for Chlamydia trachomatis and genital herpes. (23007249)
2012
6
Using centralized laboratory data to monitor trends in herpes simplex virus type 1 and 2 infection in British Columbia and the changing etiology of genital herpes. (21714324)
2011
7
Clarification in law is sought after man is jailed for infecting partner with genital herpes. (21859791)
2011
8
Effect of ASP2151, a herpesvirus helicase-primase inhibitor, in a guinea pig model of genital herpes. (21869749)
2011
9
Suppressive valacyclovir therapy to reduce genital herpes transmission: good public health policy? (19753286)
2009
10
New concepts in understanding genital herpes. (19857385)
2009
11
Comparison of nested-polymerase chain reaction and virus culture for the diagnosis of genital herpes simplex virus infection. (18581019)
2008
12
Is suspicion of genital herpes infection associated with avoiding sex? A clinic-based study. (18771644)
2008
13
Knowledge about genital herpes amongst first time attenders at a department of genitourinary medicine. (18422207)
2008
14
Famciclovir treatment options for patients with frequent outbreaks of recurrent genital herpes: the RELIEF trial. (18621575)
2008
15
Managing genital herpes infections in pregnancy. (17375803)
2007
16
Susceptibility of CCR5-deficient mice to genital herpes simplex virus type 2 is linked to NK cell mobilization. (17267483)
2007
17
Genital herpes and its management. (17510153)
2007
18
Suppressive therapy with valacyclovir in early genital herpes: a pilot study of clinical efficacy and herpes-related quality of life. (17065847)
2007
19
Genital herpes in Africa: time to rethink treatment. (18156037)
2007
20
Single-day therapy: an expert opinion on a recent development for the episodic treatment of recurrent genital herpes. (16957911)
2007
21
Adolescents anticipated experience of screening for genital herpes. (16895656)
2006
22
Imiquimod 5% cream for the treatment of recurrent, acyclovir-resistant genital herpes. (16421805)
2006
23
National survey of diagnostic services for genital herpes. (16061538)
2005
24
The cotton rat provides a novel model to study genital herpes infection and to evaluate preventive strategies. (16282463)
2005
25
Genital herpes. (16620476)
2005
26
Counseling the patient who has genital herpes or genital human papillomavirus infection. (15963883)
2005
27
Neurokinin 1 receptor signaling affects the local innate immune defense against genital herpes virus infection. (16272337)
2005
28
Genital herpes: common but misunderstood. Don't assume that genital herpes isn't your concern. (16435436)
2005
29
Genital herpes. (15652098)
2004
30
Expert commentary: genital herpes transmission. (15955269)
2004
31
The theoretical basis of stigma as applied to genital herpes. (15115630)
2004
32
Changing epidemiology of genital herpes simplex virus infection in Melbourne, Australia, between 1980 and 2003. (15295125)
2004
33
Oral famciclovir for the suppression of recurrent genital herpes: the combined data from two randomized controlled trials. (15931690)
2003
34
Study of knowledge of genital herpes infection and attitudes to testing for genital herpes among antenatal clinic attendees. (14717310)
2003
35
Predominance of herpes simplex virus type 1 from patients with genital herpes in Nova Scotia. (18159431)
2003
36
Progress in meeting today's demands in genital herpes: an overview of current management. (12353187)
2002
37
Genital herpes. (11991914)
2002
38
Aborted genital herpes simplex virus lesions: findings from a randomised controlled trial with valaciclovir. (12473805)
2002
39
Psychosocial outcomes in individuals living with genital herpes. (12353728)
2002
40
Imiquimod and genital herpes. (11939822)
2002
41
The ratio of cytokine levels in genital herpes during various phases of infection. (11687847)
2001
42
Patients' perspectives on the burden of recurrent genital herpes. (11564330)
2001
43
Seroprevalence of herpes simplex virus type 1 and type 2 in selected German populations-relevance for the incidence of genital herpes. (10797375)
2000
44
Improving the care of patients with genital herpes. (10977846)
2000
45
Cooperative agreements for strategies to prevent genital herpes infections: building a national prevention program, notice of availability of funds. Centers for Disease Control and Prevention. (10558529)
1999
46
Medication tames genital herpes. (14612772)
1999
47
Quality of life and use of health care among people with genital herpes in France. (10494718)
1999
48
Valaciclovir: new indications. In genital herpes: simpler administration. (10557565)
1999
49
Undocumented history of maternal genital herpes followed by neonatal herpes meningitis. (8064427)
1994
50
Psychological investigation of genital herpes recurrence: prospective assessment and cognitive-behavioral intervention for a chronic physical disorder. (3383831)
1988

Variations for Genital Herpes

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Expression for genes affiliated with Genital Herpes

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Search GEO for disease gene expression data for Genital Herpes.

Pathways for genes affiliated with Genital Herpes

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Pathways related to Genital Herpes according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Vitamin B12 Metabolism36
9.9CCL5, APOE
29.7CCL5, IL4, TBX21
3
Show member pathways
9.7TBX21, IL4, TLR2
4
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
9.7IL4, TLR2, DEFB4A
5
Show member pathways
9.2CCL5, CCL3, DARC
6
Show member pathways
Immune response IL 12 induced IFN gamma production58
9.1CCL3, IL4, TBX21
79.1CCL5, CCL3, TLR2
8
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.6TLR2, CCL3, CCL5, IFNA1
9
Show member pathways
8.2IL4, IFNA1, CCL5, NXF1, TLR2, HLA-B

Compounds for genes affiliated with Genital Herpes

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Compounds related to Genital Herpes according to GeneCards Suite gene sharing:

(show top 50)    (show all 85)
idCompoundScoreTop Affiliating Genes
1hbd24310.2TLR2, DEFB4A, PI3
2amphotericin b4310.0TLR2, IL4, CCL5
3betaseron439.9IL4, IFNA1
4loxoribine43 2810.9IFNA1, TLR2
5glatiramer acetate43 1210.8CCL5, IL4, IFNA1
6ursodeoxycholic acid43 24 1211.6IFNA1, APOE, HLA-B
7mip 1alpha439.5CCL5, CCL3, IL4
8anaphylatoxin439.4CCL3, CCL5, IL4
9gm-csf43 2810.4IL4, CCL5, CCL3
10resiquimod43 5910.4IFNA1, TLR2
11methacholine43 49 1211.4CCL5, CCL3, IL4
12ccl443 2810.3TLR2, CCL5, CCL3
13tarc439.3CCL3, IL4, CCL5
14chloroquine43 2 49 28 1213.3IL4, IFNA1, APOE
15peptidoglycan43 2810.3TLR2, CCL5, CCL3, DEFB4A
16sp 60012543 5910.2DEFB4A, TLR2, CCL3, CCL5
17lipoteichoic acid439.2TLR2, CCL3, HLA-B, DEFB4A
18il 10439.2TLR2, CCL5, IL4, CCL3
19ritonavir43 49 1211.2IL4, APOE, CCL3, CCL5
20heparan sulfate43 2410.2CCL3, CCL5, TLR2, GGH
21ionomycin439.1CCL3, IL4, CCL5, TLR2
22pdtc439.1CCL3, CCL5, IL4
23ccl343 2810.0TLR2, CCL3, CCL5, IFNA1
24neopterin439.0IFNA1, CCL3, IL4
25endotoxin439.0DEFB4A, CCL3, HLA-B, TLR2, CCL5
26ribonucleic acid438.9CCL5, CCL3, TLR2, HLA-B
27simvastatin43 49 59 28 24 1213.9CCL3, APOE, CCL5, IL4, TLR2
28ribavirin43 49 1210.9IFNA1, IL4, CCL3, HLA-B
29bleomycin43 129.9IFNA1, APOE, CCL3, IL4
30indomethacin43 28 59 1211.8CCL5, IL4, CCL3, APOE
31lipid438.8HLA-B, TLR2, APOE, PI3, GGH, DEFB4A
32sb 20358043 599.8CCL3, DEFB4A, PI3, TLR2, CCL5, IL4
33histamine43 28 2410.8DEFB4A, CCL3, CCL5, PI3, IL4, TLR2
34pge2438.7CCL5, HLA-B, TLR2, CCL3, IL4
35poly(i-c)438.7IL4, IFNA1, CCL3, CCL5, TLR2
36polyinosinic-polycytidylic acid438.6HLA-B, IL4, IFNA1, CCL3, TLR2
37actinomycin d438.6IFNA1, TLR2, APOE, CCL3, IL4
38h2o2438.5CCL3, HLA-B, APOE, TLR2, CCL5
39tyrosine438.5DARC, DEFB4A, CCL5, IL4, IFNA1, HLA-B
40tacrolimus43 49 1210.4IFNA1, CCL5, IL4, HLA-B, TLR2, CCL3
41cholesterol43 28 24 1211.3HLA-B, TLR2, APOE, CCL3, CCL5
42cycloheximide438.3IL4, TLR2, APOE, CCL3, CCL5, IFNA1
43vegf438.3TLR2, IL4, IFNA1, CCL5, CCL3, APOE
44alanine438.2CCL3, TLR2, GGH, IFNA1, DARC, CCL5
45retinoic acid43 249.2IFNA1, DEFB4A, PI3, HLA-B, TLR2, CCL5
46cysteine438.0DEFB4A, PI3, TLR2, CCL3, GGH, CCL5
47rantes438.0IFNA1, IL4, CCL5, TLR2, HLA-B, DEFB4A
48dexamethasone43 49 28 1210.9TLR2, CCL3, CCL5, IFNA1, IL4, HLA-B
49cyclosporin a43 28 599.9TLR2, APOE, CCL3, CCL5, IFNA1, IL4
50serine437.5IFNA1, CCL5, APOE, TLR2, HLA-B, NXF1

GO Terms for genes affiliated with Genital Herpes

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Cellular components related to Genital Herpes according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.5GGH, IL4, CCL5, CCL3, APOE

Biological processes related to Genital Herpes according to GeneCards Suite gene sharing:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of isotype switching to IgG isotypesGO:004830410.3IL4, TBX21
2positive regulation of interleukin-10 productionGO:003273310.0TLR2, IL4
3response to insulinGO:003286810.0GGH, APOE, TLR2
4response to ethanolGO:00454719.9GGH, IL4, APOE
5chemokine-mediated signaling pathwayGO:00700989.7CCL5, DARC
6positive regulation of natural killer cell chemotaxisGO:020005039.7CCL5, CCL3
7eosinophil chemotaxisGO:00482459.7CCL3, CCL5
8negative regulation by host of viral transcriptionGO:00439229.6CCL3, CCL5
9macrophage chemotaxisGO:00482469.6CCL5, CCL3
10immune responseGO:00069559.6IL4, TLR2, HLA-B, DEFB4A
11monocyte chemotaxisGO:00025489.6CCL5, CCL3
12negative regulation of osteoclast differentiationGO:00456719.5IL4, CCL3
13cellular response to interferon-gammaGO:00713469.5CCL5, CCL3
14lipopolysaccharide-mediated signaling pathwayGO:00316639.4CCL5, CCL3, TLR2
15response to toxic substanceGO:00096369.4CCL5, CCL3, TLR2
16cellular response to interleukin-1GO:00713479.4APOE, CCL3, CCL5
17positive regulation of calcium ion transportGO:00519289.4CCL3, CCL5
18protein kinase B signalingGO:00434919.4CCL5, CCL3
19cellular calcium ion homeostasisGO:00068749.4CCL5, CCL3, APOE
20positive chemotaxisGO:00509189.3CCL5, CCL3
21chemotaxisGO:00069359.2IL4, CCL5, CCL3, DEFB4A
22inflammatory responseGO:00069549.2DARC, TLR2, CCL3, CCL5

Molecular functions related to Genital Herpes according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1phospholipase activator activityGO:00160049.4CCL5, CCL3
2chemoattractant activityGO:00420569.4CCL5, CCL3
3CCR1 chemokine receptor bindingGO:00317269.3CCL5, CCL3
4CCR5 chemokine receptor bindingGO:00317309.1CCL5, CCL3

Products for genes affiliated with Genital Herpes

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Sources for Genital Herpes

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet