MCID: GNT003
MIFTS: 58

Genital Herpes

Categories: Reproductive diseases, Infectious diseases

Aliases & Classifications for Genital Herpes

MalaCards integrated aliases for Genital Herpes:

Name: Genital Herpes 12 51 40 3 14 69
Herpes Genitalis 12 41
Genital Herpes Simplex 12
Virus-Genital Herpes 12
Herpes Genitalia 12
Venereal Herpes 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8704
ICD9CM 34 054.1 054.10
MeSH 41 D006558
NCIt 46 C14364
UMLS 69 C0019342

Summaries for Genital Herpes

MedlinePlus : 40 Genital herpes is a sexually transmitted disease (STD) caused by a herpes simplex virus (HSV). It can cause sores on your genital or rectal area, buttocks, and thighs. You can get it from having vaginal, anal, or oral sex with someone who has it. The virus can spread even when sores are not present. Mothers can also infect their babies during childbirth. Symptoms of herpes are called outbreaks. You usually get sores near the area where the virus has entered the body. The sores are blisters which break and become painful, and then heal. Sometimes people do not know they have herpes because they have no symptoms or very mild symptoms. The virus can be more serious in newborn babies or in people with weak immune systems. Repeat outbreaks are common, especially during the first year. Over time, you get them less often and the symptoms become milder. The virus stays in your body for life. There are tests that can diagnose genital herpes. There is no cure. However, medicines can help lessen symptoms, decrease outbreaks, and lower the risk of passing the virus to others. Correct usage of latex condoms can reduce, but not eliminate, the risk of catching or spreading herpes. The most reliable way to avoid infection is to not have anal, vaginal, or oral sex.

MalaCards based summary : Genital Herpes, also known as herpes genitalis, is related to meningitis and keratitis, hereditary, and has symptoms including sores, fever and swollen gl. An important gene associated with Genital Herpes is ACKR1 (Atypical Chemokine Receptor 1 (Duffy Blood Group)), and among its related pathways/superpathways are Akt Signaling and Influenza A. The drugs Famciclovir and Acyclovir have been mentioned in the context of this disorder. Affiliated tissues include genital system, rectum and testes, and related phenotypes are digestive/alimentary and hematopoietic system

Disease Ontology : 12 A herpes simplex that results_in infection located in genital system, or located in rectum, has material basis in Human herpesvirus 1 or has material basis in Human herpesvirus 2, which is transmitted_by sexual contact. The infection has symptom sores, has symptom fever, and has symptom swollen glands.

Wikipedia : 72 Genital herpes is an infection by herpes simplex virus (HSV) of the genitals. Most people either have no... more...

Related Diseases for Genital Herpes

Diseases related to Genital Herpes via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 151)
# Related Disease Score Top Affiliating Genes
1 meningitis 29.1 IL10 TLR2 TLR9
2 keratitis, hereditary 28.9 ACKR1 TLR2 TLR9
3 herpes simplex 11.7
4 herpes simplex encephalitis 11.3
5 tropical endomyocardial fibrosis 10.5 IL10 IL4
6 hyperlucent lung 10.5 IL10 IL4
7 tungiasis 10.4 IL10 IL4
8 endomyocardial fibrosis 10.4 IL10 IL4
9 immunoglobulin a deficiency 1 10.4 IL10 IL4
10 retinitis pigmentosa 22 10.4 IL10 IL4
11 baylisascariasis 10.4 IL10 IL4
12 gastrointestinal allergy 10.4 CCL5 IL4
13 vulvovaginitis 10.4 CCL5 IL10
14 apple allergy 10.4 IL10 IL4
15 beta-lactam allergy 10.4 IL10 IL4
16 chronic conjunctivitis 10.4 CCL5 IL4
17 kimura disease 10.4 CCL5 IL4
18 buruli ulcer 10.4 IL10 IL4
19 folliculitis 10.4 CCL5 IL4
20 vernal keratoconjunctivitis 10.3 CCL5 IL4
21 poliomyelitis 10.3 IL10 IL4
22 griscelli syndrome, type 2 10.3 CCL5 IL10
23 penicillin allergy 10.3 IL18 IL4
24 bardet-biedl syndrome 15 10.3 IL10 IL4
25 orofacial granulomatosis 10.3 CCL5 IL10 IL4
26 latex allergy 10.3 IL18 IL4
27 necrotizing ulcerative gingivitis 10.2 IL10 IL18
28 eales disease 10.2 IL10 IL4
29 radiculopathy 10.2 CCL5 IL10
30 allergic asthma 10.2 CCL5 IL10 IL4
31 interstitial lung disease 10.2 CCL5 IL10 IL4
32 eosinophilic gastritis 10.2 IL18 IL4
33 polyradiculoneuropathy 10.2 CCL5 IL10 TBX21
34 cow milk allergy 10.2 IL10 IL18
35 stachybotrys chartarum 10.2 CCL5 IL18
36 neurosyphilis 10.2 IL10 TLR2
37 mycetoma 10.2 CCL5 IL10
38 acute cervicitis 10.2 CCL5 TLR2
39 extrinsic allergic alveolitis 10.1 CCL5 IL10 PI3
40 spotted fever 10.1 CCL5 IL10
41 acute graft versus host disease 10.1 IL10 IL18 IL4
42 mucositis 10.1
43 vaginitis 10.1
44 traumatic brain injury 10.1 APOE IL10
45 brucellosis 10.1 IL10 IL18 IL4
46 allergic rhinitis 10.0 IL10 IL18 IL4
47 primary systemic mycosis 10.0 IL10 IL4 TLR2
48 eye lymphoma 10.0 IL10 TLR9
49 rheumatic heart disease 10.0 IL10 IL4 TLR2
50 leprosy 3 10.0 IL10 IL4 TLR2

Comorbidity relations with Genital Herpes via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Genital Herpes:



Diseases related to Genital Herpes

Symptoms & Phenotypes for Genital Herpes

Symptoms:

12
  • sores
  • fever
  • swollen gl

UMLS symptoms related to Genital Herpes:


pruritus, pelvic pain, fever

MGI Mouse Phenotypes related to Genital Herpes:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.7 IL10 IL18 IL4 TBX21 TLR2 TLR9
2 hematopoietic system MP:0005397 9.56 CCL5 IL10 IL18 IL4 TBX21 TLR2
3 immune system MP:0005387 9.28 IL10 IL18 IL4 TBX21 TLR2 TLR9

Drugs & Therapeutics for Genital Herpes

Drugs for Genital Herpes (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Famciclovir Approved, Investigational Phase 4,Phase 3 104227-87-4 3324
2 Acyclovir Phase 4,Phase 3,Phase 2,Phase 1
3 valacyclovir Phase 4,Phase 3,Phase 2,Phase 1
4 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
5 Antiviral Agents Phase 4,Phase 3,Phase 2,Phase 1
6
Tenofovir Phase 4 147127-20-6 464205
7 2-Aminopurine Phase 4,Phase 3
8 Reverse Transcriptase Inhibitors Phase 4
9 Nucleic Acid Synthesis Inhibitors Phase 4
10 Anti-HIV Agents Phase 4
11 Antimetabolites Phase 4,Phase 3
12 Anti-Retroviral Agents Phase 4
13
Halofantrine Approved Phase 3 69756-53-2 37393
14
Aluminum sulfate Approved Phase 3 10043-01-3
15 Monophosphoryl lipid A Phase 3
16 interferons Phase 3
17 Adjuvants, Immunologic Phase 3,Phase 2
18 Vaccines Phase 3,Phase 2,Phase 1
19 Anti-Bacterial Agents Phase 3
20 Interferon Inducers Phase 3
21 Protective Agents Phase 3
22 Krestin Phase 3,Phase 2
23 Antibiotics, Antitubercular Phase 3
24 Radiation-Protective Agents Phase 3
25
QS 21 Phase 2 141256-04-4
26 Lecithin Nutraceutical Phase 2

Interventional clinical trials:

(show top 50) (show all 72)

# Name Status NCT ID Phase Drugs
1 Patient-initiated Episodic Treatment of Recurrent Genital Herpes in Black Patients Completed NCT00477334 Phase 4 Famciclovir;Placebo
2 A Study Comparing Daily Treatment With Valaciclovir To Placebo For Suppression Of Herpes Simplex Virus HSV-2 Genital Herpes In Newly Diagnosed Patients. VALTREX® Tablet is a Trademark of the GlaxoSmithKline Group of Companies. Completed NCT00158860 Phase 4 valaciclovir (VALTREX®)
3 RELIEF: Randomized Episodic Versus Long-Term Suppression Experience With Famciclovir Completed NCT00219310 Phase 4 Famciclovir
4 A Study to Evaluate the Effect of Famciclovir in Reducing Herpes Virus Shedding Completed NCT00129818 Phase 4 Famciclovir
5 Effect of Tenofovir on Genital Herpes Simplex Virus (HSV) Shedding Completed NCT01448616 Phase 4 TDF;Placebo Vaginal Gel;Vaginal TFV Gel;Placebo Tablets
6 Randomized Trial to Evaluate Suppressive Effect of High-Dose Valacyclovir Versus Once-Daily Valacyclovir on Persons With HSV-2 Completed NCT01346475 Phase 4 valacyclovir;Valacyclovir
7 Trial to Study the Effect of Dose of Herpes Simplex Virus-2 (HSV-2) Suppressive Therapy on HSV and HIV Completed NCT00527618 Phase 4 valacyclovir;acyclovir
8 Randomized Trial to Evaluate Suppressive Effect of High-Dose Acyclovir Versus Once-Daily Valacyclovir on Persons With HSV-2 Completed NCT00362297 Phase 4 acyclovir;valacyclovir
9 VALTREX(Valacyclovir) Once Daily for Viral Shedding In Subjects Newly Diagnosed With HSV-2 Completed NCT00306293 Phase 4 valacyclovir
10 A Randomized Trial to Evaluated the Suppressive Effect of Acyclovir on Rapidly Cleared HSV-2 Reactivation Completed NCT00723229 Phase 4 acyclovir
11 VALTREX Once Daily For Viral Shedding In Herpes Simplex Virus 2 (HSV-2) Seropositive Subjects. VALTREX® Tablet is a Trademark of GlaxoSmithKline Group of Companies. Completed NCT00116844 Phase 4 Valaciclovir;Placebo
12 Effect of HSV-2 Suppressive Therapy on Sexual Behavior Active, not recruiting NCT00495716 Phase 4 acyclovir;acyclovir
13 A Clinical Research Study For The Suppression And Treatment Of Genital Herpes Infection In HIV-Infected Persons Terminated NCT00079911 Phase 4 valacyclovir hydrochloride
14 A Study of Valacyclovir as Treatment for Genital Herpes Simplex Virus in HIV-Infected Patients Unknown status NCT00005663 Phase 3 Valacyclovir hydrochloride
15 Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and the Community Unknown status NCT00124878 Phase 3
16 Efficacy and Safety of Famciclovir 1-day Treatment Compared to 3-day Treatment With Valacyclovir in Adults With Recurrent Genital Herpes Completed NCT00306787 Phase 3 Famciclovir;Valacyclovir;Placebo matching famciclovir;Placebo matching valacyclovir
17 Efficacy and Safety of Oral Famciclovir in Patients With Active Recurrent Genital Herpes Completed NCT00171990 Phase 3 Famciclovir
18 Efficacy of Oral Famciclovir 125mg Comparing to Aciclovir 200 mg Treatment in Patients With Active Recurrent Genital Herpes Completed NCT01281007 Phase 3 Famciclovir;Aciclovir
19 Safety of a Herpes Simplex Candidate Vaccine (gD2t) With MPL and Its Efficacy to Prevent Genital Herpes Disease Completed NCT00699764 Phase 3
20 HerpeVac Trial for Young Women Completed NCT00057330 Phase 3
21 A Study of Acyclovir to Help Prevent HIV Infection in People With Genital Herpes Completed NCT00076232 Phase 3 Acyclovir;Acyclovir placebo
22 Safety Evaluation of Herpes Simplex Candidate Vaccine (gD2t) With Adjuvant in HSV Seropositive / Seronegative Subjects Completed NCT00698568 Phase 3
23 Herpes Simplex Virus Type 2 (HSV-2) Suppression to Prevent HIV Transmission Completed NCT00194519 Phase 3 Generic acyclovir;Placebo
24 Open-label Study of ASP2151 in Herpes Simplex Patients Completed NCT02209324 Phase 3 ASP2151
25 Valaciclovir to Prevent Transmission of Herpes Simplex Virus Completed NCT00001649 Phase 3 Valaciclovir
26 Trial to Evaluate PRO 2000/5 Gels for the Prevention of Vaginally Acquired HIV Infection Completed NCT00262106 Phase 3 PRO 2000/5;Placebo
27 Can Valacyclovir Delay the Need for Initiation of Human Immunodeficiency Virus (HIV) Treatment in HIV-infected Individuals? Active, not recruiting NCT00860977 Phase 3 valacyclovir;Placebo
28 Effect of Male Circumcision on HIV Incidence (ANRS 1265) Terminated NCT00122525 Phase 3
29 A Study With ASP2151 in Subjects With Recurrent Episodes of Genital Herpes Completed NCT00486200 Phase 2 ASP2151;valacyclovir;Placebo
30 Biological Efficacy Study of HerpV Vaccine With QS-21 to Treat Subjects With Recurrent Genital Herpes Completed NCT01687595 Phase 2 HerpV and QS-21;Placebo
31 Randomised Controlled Trial Assessing the Impact of Genital Herpes Suppressive Therapy on HIV Shedding Completed NCT00158509 Phase 2 Valacyclovir
32 Evaluating New Formulation of Therapeutic HSV-2 Vaccine Completed NCT02515175 Phase 2 Placebo
33 Safety and Efficacy Trial of DNA Vaccines to Treat Genital Herpes in Adults Completed NCT02030301 Phase 1, Phase 2
34 Safety and Efficacy Study for a New Antiviral Drug to Treat Genital Herpes Type 2 Completed NCT01047540 Phase 2 AIC316;AIC316;AIC316;AIC316;Placebo
35 Dose Ranging Safety and Efficacy of Therapeutic HSV-2 Vaccine Completed NCT02114060 Phase 2
36 Rollover Trial for Placebo Subjects Previously Enrolled Into GEN-003-002 Study Completed NCT02300142 Phase 2
37 Safety and Immunogenicity Study of Therapeutic HSV-2 Vaccine Completed NCT01667341 Phase 1, Phase 2
38 Retention and Duration of Activity of SPL7013 (VivaGel®) After Vaginal Dosing. Completed NCT00740584 Phase 1, Phase 2 3% SPL7013 Gel (VivaGel)
39 Anti-Herpetic Treatment of Genital Ulcer : Effect on HIV & Herpes Shedding (ANRS 1212) Completed NCT00158483 Phase 2 Acyclovir (ACV)
40 Acyclovir to Treat Patients Co-infected With HIV and Herpes Viruses in Uganda Completed NCT00405821 Phase 2 Acyclovir;Placebo
41 Maintenance Dose Study of GEN-003 in Subjects With Genital Herpes Infection Active, not recruiting NCT03146403 Phase 2
42 Safety and Efficacy Study of Herpes Simplex Virus Type 2 (HSV-2) Therapeutic DNA Vaccine Active, not recruiting NCT02837575 Phase 2
43 A Study to Investigate the Efficacy, Safety and Tolerability of PEG in Patients With Genital Herpes Terminated NCT01765114 Phase 2 PEG-Formulation
44 Safety and Efficacy Comparator Trial of a New Drug Against Genital Herpes Terminated NCT01658826 Phase 2 AIC316;Valacyclovir
45 Safety Study of HSV2 DNA Vaccine to Treat Patients With Recurrent Genital Herpes Caused by HSV-2 Completed NCT00274300 Phase 1
46 Trial Evaluating Safety, Tolerability and Immune Response of AG-707 Completed NCT00231049 Phase 1 AG-707
47 Study of the Safety of a Particular Herpes Vaccine in Adults With or Without Herpes Infection Completed NCT01915212 Phase 1
48 Study to Evaluate the Safety and Pharmacokinetics of Single Doses of ASP2151 in Healthy Male Subjects and the Effects of Food Completed NCT02852876 Phase 1 ASP2151;Placebo
49 Evaluating Three Grams Daily Valacyclovir in Patients With Chronic Hepatitis C and HSV-2 Infection (Phase I) Completed NCT01453075 Phase 1 Valacyclovir;Placebo
50 Safety and Efficacy of Famciclovir in HIV1 Positive Adults With Recurrent Genital Herpes Completed NCT01154543

Search NIH Clinical Center for Genital Herpes

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: herpes genitalis

Genetic Tests for Genital Herpes

Anatomical Context for Genital Herpes

The Foundational Model of Anatomy Ontology organs/tissues related to Genital Herpes:

18
Genital System, Rectum

MalaCards organs/tissues related to Genital Herpes:

38
Testes, T Cells, Cervix, Skin, B Cells, Nk Cells, Myeloid

Publications for Genital Herpes

Articles related to Genital Herpes:

(show top 50) (show all 597)
# Title Authors Year
1
A Comparative Analysis of Polymerase Chain Reaction and Direct Fluorescent Antibody Test for Diagnosis of Genital Herpes. ( 28042218 )
2017
2
Serologic Screening for Genital Herpes Infection. ( 28671417 )
2017
3
Prospective cohort study showing persistent HSV-2 shedding in women with genital herpes 2 years after acquisition. ( 29175899 )
2017
4
Comparison of Acyclovir and Multistrain Lactobacillus brevis in Women with Recurrent Genital Herpes Infections: a Double-Blind, Randomized, Controlled Study. ( 28852985 )
2017
5
Primary syphilis in pregnancy mistaken for genital herpes: A preventable cause of congenital syphilis. ( 29103618 )
2017
6
Leflunomide in the Treatment of a Pseudotumoral Genital Herpes Simplex Virus Infection in an HIV Patient. ( 28373917 )
2017
7
Genital Herpes Infection in an Adolescent with Diabetes Mellitus. ( 28891491 )
2017
8
Genital herpes. ( 28619732 )
2017
9
Therapeutic Vaccine for Genital Herpes Simplex Virus-2 Infection: Findings From a Randomized Trial. ( 28329211 )
2017
10
Extensive and refractory genital herpes in human immunodeficiency virus-infected patient successfully treated with imiquimod: Case report and literature review. ( 28164895 )
2017
11
Cutting Edge: Genetic Association between IFI16 Single Nucleotide Polymorphisms and Resistance to Genital Herpes Correlates with IFI16 Expression Levels and HSV-2-Induced IFN-I^ Expression. ( 28893956 )
2017
12
Dual-strain genital herpes simplex virus type 2 (HSV-2) infection in the US, Peru, and 8 countries in sub-Saharan Africa: A nested cross-sectional viral genotyping study. ( 29281620 )
2017
13
Potential risk of developing herpes simplex encephalitis in patients treated with sildenafil following primary exposure to genital herpes. ( 28956417 )
2017
14
A trivalent subunit antigen glycoprotein vaccine as immunotherapy for genital herpes in the guinea pig genital infection model. ( 28481687 )
2017
15
Serologic Screening for Genital Herpes Infection: Recommendation Statement. ( 28671418 )
2017
16
A case of MOG antibody-positive bilateral optic neuritis and meningoganglionitis following a genital herpes simplex virus infection. ( 29055448 )
2017
17
First-episode genital herpes: interventions for men and women. ( 28120659 )
2017
18
2017 European guidelines for the management of genital herpes. ( 28836892 )
2017
19
A model of genital herpes simplex virus Type 1 infection in Rhesus Macaques. ( 28748667 )
2017
20
Dorsal longitudinal foreskin cut is associated with reduced risk of HIV, syphilis and genital herpes in men: a cross-sectional study in Papua New Guinea. ( 28406272 )
2017
21
The occurrence of herpes simplex viruses 1 and 2 in skin and mucosal lesions in patients with suspicion of genital herpes. ( 28146623 )
2016
22
Current Concepts for Genital Herpes Simplex Virus Infection: Diagnostics and Pathogenesis of Genital Tract Shedding. ( 26561565 )
2016
23
Role of type-specific herpes simplex virus-1 and 2 serology as a diagnostic modality in patients with clinically suspected genital herpes: A comparative study in Indian population from a tertiary care hospital. ( 27510668 )
2016
24
Genital Herpes: What You Should Know. ( 27281843 )
2016
25
CLINICAL PRACTICE. Genital Herpes. ( 27532832 )
2016
26
Effects of a traditional Chinese medicine, Longdanxiegan formula granule, on Toll-like receptor pathway in female guinea pigs with recurrent genital herpes. ( 27125405 )
2016
27
Medroxyprogesterone acetate and levonorgestrel increase genital mucosal permeability and enhance susceptibility to genital herpes simplex virus type 2 infection. ( 27007679 )
2016
28
A Recommendation Against Serologic Screening for Genital Herpes Infection-What Now? ( 27997636 )
2016
29
First HSV-1 non primary genital herpes in two patients. ( 27018573 )
2016
30
Unfortunate synergy between HIV and genital herpes. ( 26884529 )
2016
31
Optimal management of genital herpes: current perspectives. ( 27358569 )
2016
32
False-negative type-specific glycoprotein G antibody responses in STI clinic patients with recurrent HSV-1 or HSV-2 DNA positive genital herpes, The Netherlands. ( 26755775 )
2016
33
Serologic Screening for Genital Herpes: An Updated Evidence Report and Systematic Review for the US Preventive Services Task Force. ( 27997660 )
2016
34
Serologic Screening for Genital Herpes Infection: US Preventive Services Task Force Recommendation Statement. ( 27997659 )
2016
35
Genital Herpes. ( 27959656 )
2016
36
Clinical study of Gene-Eden-VIR/Novirin in genital herpes: suppressive treatment safely decreases the duration of outbreaks in both severe and mild cases. ( 27766602 )
2016
37
Heterogeneous polymer composite nanoparticles loaded in situ gel for controlled release intra-vaginal therapy of genital herpes. ( 27351137 )
2016
38
Collaboration with a midwife in the care of a pregnant patient with recurrent genital herpes simplex virus. ( 27412208 )
2016
39
Evolution of rational vaccine designs for genital herpes immunotherapy. ( 26896782 )
2016
40
Protection from genital herpes disease, seroconversion and latent infection in a non-lethal murine genital infection model by immunization with an HSV-2 replication-defective mutant virus. ( 26609935 )
2016
41
Integrative pharmacokinetic-pharmacodynamic modeling and simulation of amenamevir (ASP2151) for treatment of recurrent genital herpes. ( 27461507 )
2016
42
OASL1 deficiency promotes antiviral protection against genital herpes simplex virus type 2 infection by enhancing type I interferon production. ( 26750802 )
2016
43
Genital Herpes: A Review. ( 27281837 )
2016
44
Herpes simplex virus: 'to disclose or not to disclose.' An exploration of the multi-disciplinary team's role in advising patients about disclosure when diagnosed with genital herpes simplex virus. ( 27582307 )
2016
45
Clinical study in genital herpes: natural Gene-Eden-VIR/Novirin versus acyclovir, valacyclovir, and famciclovir. ( 27621592 )
2016
46
Genital herpes. ( 27109044 )
2016
47
Genital Herpes. ( 27959657 )
2016
48
Intravaginal Zinc Oxide Tetrapod Nanoparticles as Novel Immunoprotective Agents against Genital Herpes. ( 27183601 )
2016
49
Genital Herpes: Insights into Sexually Transmitted Infectious Disease. ( 28357380 )
2016
50
Screening for Genital Herpes: What Is Not to Be Done. ( 27997634 )
2016

Variations for Genital Herpes

Expression for Genital Herpes

Search GEO for disease gene expression data for Genital Herpes.

Pathways for Genital Herpes

Pathways related to Genital Herpes according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.2 CCL5 IL10 IL18 IL4 TLR2 TLR9
2
Show member pathways
12.6 CCL5 IL18 IL4 TLR2 TLR9
3
Show member pathways
12.34 CCL5 IL10 TLR2 TLR9
4
Show member pathways
12.34 IL10 IL18 IL4 TBX21 TLR2
5 12.15 CCL5 IL10 IL4 TBX21 TLR2 TLR9
6
Show member pathways
12.06 IL10 IL4 TLR2
7 12.03 IL10 IL18 TLR2 TLR9
8
Show member pathways
11.98 IL4 TLR2 TLR9
9
Show member pathways
11.97 IL10 IL18 IL4
10 11.8 IL10 IL18 IL4
11
Show member pathways
11.79 IL18 IL4 TBX21
12
Show member pathways
11.67 IL4 TLR2 TLR9
13 11.65 CCL5 IL18 TLR2
14 11.57 IL10 IL18 IL4 TBX21
15 11.44 IL10 IL4 TLR2 TLR9
16
Show member pathways
11.37 IL10 IL18 TBX21 TLR2 TLR9
17 11.25 CCL5 IL10 IL18 IL4
18 11.18 IL10 IL18 TLR9
19 11.11 IL18 IL4 TBX21
20 11.1 IL10 IL4
21 11.06 IL18 TBX21
22 11.03 CCL5 IL10 IL18 IL4
23 11.02 IL10 IL4
24 11 IL18 TLR2
25 10.83 CCL5 IL10 IL18 IL4
26 10.71 ACKR1 IL10 IL18 TLR2 TLR9

GO Terms for Genital Herpes

Cellular components related to Genital Herpes according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 APOE CCL5 IL10 IL18 IL4 PI3
2 extracellular space GO:0005615 9.17 APOE CCL5 IFNL4 IL10 IL18 IL4
3 amyloid-beta complex GO:0106003 8.96 APOE TLR2

Biological processes related to Genital Herpes according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.89 CCL5 IL10 IL18 IL4 TLR2
2 regulation of receptor activity GO:0010469 9.77 CCL5 IFNL4 IL10 IL18 IL4
3 positive regulation of inflammatory response GO:0050729 9.7 IL18 TLR2 TLR9
4 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.65 TLR2 TLR9
5 negative regulation of endothelial cell apoptotic process GO:2000352 9.64 IL10 IL4
6 triglyceride homeostasis GO:0070328 9.64 APOE IL18
7 positive regulation of interleukin-8 production GO:0032757 9.63 TLR2 TLR9
8 negative regulation of interleukin-6 production GO:0032715 9.63 IL10 TLR9
9 positive regulation of interferon-beta production GO:0032728 9.62 TLR2 TLR9
10 positive regulation of interleukin-12 production GO:0032735 9.62 TLR2 TLR9
11 positive regulation of interleukin-10 production GO:0032733 9.61 TLR2 TLR9
12 positive regulation of chemokine production GO:0032722 9.61 TLR2 TLR9
13 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.6 TLR2 TLR9
14 I-kappaB phosphorylation GO:0007252 9.59 TLR2 TLR9
15 regulation of cytokine secretion GO:0050707 9.58 TLR2 TLR9
16 neutrophil activation GO:0042119 9.58 CCL5 IL18
17 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.57 IL18 TLR9
18 regulation of T cell activation GO:0050863 9.56 CCL5 IFNL4
19 positive regulation of isotype switching to IgG isotypes GO:0048304 9.55 IL4 TBX21
20 positive regulation of MHC class II biosynthetic process GO:0045348 9.54 IL10 IL4
21 negative regulation of interleukin-8 production GO:0032717 9.51 IL10 TLR9
22 lipopolysaccharide-mediated signaling pathway GO:0031663 9.5 CCL5 IL18 TLR2
23 regulation of isotype switching GO:0045191 9.48 IL10 IL4
24 positive regulation of interleukin-18 production GO:0032741 9.46 TLR2 TLR9
25 tumor necrosis factor production GO:0032640 9.43 TLR2 TLR9
26 positive regulation of NF-kappaB import into nucleus GO:0042346 9.43 IL18 TLR2 TLR9
27 inflammatory response GO:0006954 9.43 ACKR1 CCL5 IL10 IL18 TLR2 TLR9
28 positive regulation of toll-like receptor signaling pathway GO:0034123 9.4 TLR2 TLR9
29 response to molecule of bacterial origin GO:0002237 9.33 IL10 TLR2 TLR9
30 type 2 immune response GO:0042092 8.8 IL10 IL18 IL4
31 positive regulation of transcription by RNA polymerase II GO:0045944 10.04 IL10 IL18 IL4 TLR2 TLR9

Molecular functions related to Genital Herpes according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CCL5 IFNL4 IL10 IL18 IL4

Sources for Genital Herpes

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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