Genital Herpes

Categories: Infectious diseases, Reproductive diseases

Aliases & Classifications for Genital Herpes

MalaCards integrated aliases for Genital Herpes:

Name: Genital Herpes 12 52 41 3 3 3 3 14 69
Herpes Genitalis 12 42
Genital Herpes Simplex 12
Virus-Genital Herpes 12
Herpes Genitalia 12
Venereal Herpes 12


External Ids:

Disease Ontology 12 DOID:8704
ICD9CM 35 054.1 054.10
MeSH 42 D006558
NCIt 47 C14364
UMLS 69 C0019342

Summaries for Genital Herpes

MedlinePlus : 41 genital herpes is a sexually transmitted disease (std) caused by a herpes simplex virus (hsv). it can cause sores on your genital or rectal area, buttocks, and thighs. you can get it from having vaginal, anal, or oral sex with someone who has it. the virus can spread even when sores are not present. mothers can also infect their babies during childbirth. symptoms of herpes are called outbreaks. you usually get sores near the area where the virus has entered the body. the sores are blisters which break and become painful, and then heal. sometimes people do not know they have herpes because they have no symptoms or very mild symptoms. the virus can be more serious in newborn babies or in people with weak immune systems. repeat outbreaks are common, especially during the first year. over time, you get them less often and the symptoms become milder. the virus stays in your body for life. there are tests that can diagnose genital herpes. there is no cure. however, medicines can help lessen symptoms, decrease outbreaks, and lower the risk of passing the virus to others. correct usage of latex condoms can reduce, but not eliminate, the risk of catching or spreading herpes. nih: national institute of allergy and infectious diseases

MalaCards based summary : Genital Herpes, also known as herpes genitalis, is related to lymphoma and herpes simplex, and has symptoms including fever, pelvic pain and pruritus. An important gene associated with Genital Herpes is ACKR1 (Atypical Chemokine Receptor 1 (Duffy Blood Group)), and among its related pathways/superpathways are Akt Signaling and Toll-like Receptor Signaling Pathway. The drugs Famciclovir and Metronidazole have been mentioned in the context of this disorder. Affiliated tissues include testes, t cells and cervix, and related phenotypes are digestive/alimentary and hematopoietic system

Disease Ontology : 12 A herpes simplex that results_in infection located in genital system, or located in rectum, has material basis in Human herpesvirus 1 or has material basis in Human herpesvirus 2, which is transmitted_by sexual contact. The infection has symptom sores, has symptom fever, and has symptom swollen glands.

Wikipedia : 72 Genital herpes is a genital infection caused by the herpes simplex virus (HSV). Most individuals... more...

Related Diseases for Genital Herpes

Diseases related to Genital Herpes via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 142)
id Related Disease Score Top Affiliating Genes
1 lymphoma 29.6 IL10 IL4 TLR9
2 herpes simplex 11.6
3 herpes simplex encephalitis 10.9
4 acute ackee fruit intoxication 10.7 IL10 IL4
5 eye accommodation disease 10.7 IL10 IL4
6 basidiobolomycosis 10.7 IL10 IL4
7 diabetic angiopathy 10.7 IL10 IL4
8 lagophthalmos 10.6 IL10 IL4
9 apple allergy 10.6 CCL5 IL4
10 thelaziasis 10.6 IL10 IL4
11 deafness, autosomal recessive 22 10.6 IL10 IL4
12 liver leiomyoma 10.6 IL10 IL4
13 trachea leiomyoma 10.6 CCL5 IL4
14 cherry allergy 10.6 IL10 IL4
15 female urethral cancer 10.6 CCL5 IL4
16 cow milk allergy 10.6 IL10 IL4
17 hidradenitis suppurativa 10.6 CCL5 IL10
18 centronuclear myopathy 5 10.6 IL10 IL4
19 fibrous histiocytoma 10.6 CCL5 IL4
20 viljoen kallis voges syndrome 10.6 CCL5 IL4
21 spindle cell hemangioma 10.5 IL10 IL4
22 purpura fulminans 10.5 IL18 IL4
23 craniosynostosis 3 10.5 CCL5 IL10
24 bardet-biedl syndrome 15 10.5 IL10 IL4
25 fungal gastritis 10.5 IL18 IL4
26 phlyctenulosis 10.5 IL10 IL4
27 early-onset zonular cataract 10.5 IL10 IL4
28 facial paralysis 10.4 IL10 IL18
29 crustacean allergy 10.4 IL10 IL18
30 stargardt macular degeneration absent or hypoplastic corpus callosum mental retardation and dysmorphic features 10.4 CCL5 IL18
31 myofascial pain syndrome 10.4 CCL5 IL10
32 peroneal nerve paralysis 10.4 IL10 TLR9
33 oropharyngeal cancer, childhood 10.4 CCL5 IL10 IL4
34 mycobacterium gordonae 10.4 CCL5 IL10
35 psychologic dyspareunia 10.3 CCL5 IL10
36 intracranial hypertension 10.3 CCL5 IL10 IL4
37 granulomatous orchitis 10.3 CCL5 IL10 IL4
38 fanconi syndrome 10.3 CCL5 TLR2
39 neutrophil-specific granule deficiency 10.3 IL10 TLR2
40 ulcerative colitis 10.3 APOE IL10
41 acute monoblastic leukemia 10.2 IL10 IL18 IL4
42 esophagus melanoma 10.2 IL10 IL18 IL4
43 dysphagia 10.2 CCL5 IL10
44 vulvar nodular hidradenoma 10.2 IL10 IL18 IL4
45 dentin caries 10.2 CCL5 IL4 TLR9
46 tularemia 10.2 IL10 IL4 TLR9
47 malignant epithelial mesothelioma 10.2 CCL5 IL4 TLR9
48 ostertagiasis 10.2 IL10 IL4 TLR9
49 eyelid neoplasm 10.2 IL10 IL4 TLR9
50 motor peripheral neuropathy 10.2 IL10 IL4 TLR9

Comorbidity relations with Genital Herpes via Phenotypic Disease Network (PDN):

Acute Cystitis

Graphical network of the top 20 diseases related to Genital Herpes:

Diseases related to Genital Herpes

Symptoms & Phenotypes for Genital Herpes

UMLS symptoms related to Genital Herpes:

fever, pelvic pain, pruritus

MGI Mouse Phenotypes related to Genital Herpes:

id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.92 IL10 IL18 IL4 T TBX21 TLR2
2 hematopoietic system MP:0005397 9.86 IL4 TBX21 TLR2 TLR9 APOE CCL5
3 homeostasis/metabolism MP:0005376 9.81 ACKR1 APOE IL10 IL18 IL4 T
4 immune system MP:0005387 9.61 ACKR1 APOE CCL5 IL10 IL18 IL4
5 integument MP:0010771 9.1 APOE IL10 IL18 IL4 T TLR2

Drugs & Therapeutics for Genital Herpes

Drugs for Genital Herpes (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
id Name Status Phase Clinical Trials Cas Number PubChem Id
Famciclovir Approved Phase 4,Phase 3 104227-87-4 3324
Metronidazole Approved Phase 4 443-48-1 4173
3 Acyclovir Phase 4,Phase 3,Phase 2,Phase 1
4 valacyclovir Phase 4,Phase 3,Phase 2,Phase 1
5 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
6 Antiviral Agents Phase 4,Phase 3,Phase 2,Phase 1
Tenofovir Phase 4 147127-20-6 464205
8 2-Aminopurine Phase 4,Phase 3
9 Reverse Transcriptase Inhibitors Phase 4
10 Nucleic Acid Synthesis Inhibitors Phase 4
11 Anti-HIV Agents Phase 4
12 Anti-Retroviral Agents Phase 4
13 Antimetabolites Phase 4,Phase 3
14 Antiprotozoal Agents Phase 4
15 Antiparasitic Agents Phase 4
Halofantrine Approved Phase 3 69756-53-2 37393
Aluminum sulfate Approved Phase 3 10043-01-3
18 Monophosphoryl lipid A Phase 3
19 interferons Phase 3
20 Adjuvants, Immunologic Phase 3,Phase 2
21 Vaccines Phase 3,Phase 2,Phase 1
22 Anti-Bacterial Agents Phase 3
23 Interferon Inducers Phase 3
24 Krestin Phase 3,Phase 2
25 Protective Agents Phase 3
26 Antibiotics, Antitubercular Phase 3
27 Radiation-Protective Agents Phase 3
QS 21 Phase 2 141256-04-4
29 Lecithin Nutraceutical Phase 2
30 Immunoglobulins
31 Antibodies

Interventional clinical trials:

(show top 50) (show all 82)

id Name Status NCT ID Phase Drugs
1 Patient-initiated Episodic Treatment of Recurrent Genital Herpes in Black Patients Completed NCT00477334 Phase 4 Famciclovir;Placebo
2 A Study Comparing Daily Treatment With Valaciclovir To Placebo For Suppression Of Herpes Simplex Virus HSV-2 Genital Herpes In Newly Diagnosed Patients. VALTREX® Tablet is a Trademark of the GlaxoSmithKline Group of Companies. Completed NCT00158860 Phase 4 valaciclovir (VALTREX®)
3 RELIEF: Randomized Episodic Versus Long-Term Suppression Experience With Famciclovir Completed NCT00219310 Phase 4 Famciclovir
4 A Study to Evaluate the Effect of Famciclovir in Reducing Herpes Virus Shedding Completed NCT00129818 Phase 4 Famciclovir
5 Effect of Tenofovir on Genital Herpes Simplex Virus (HSV) Shedding Completed NCT01448616 Phase 4 TDF;Placebo Vaginal Gel;Vaginal TFV Gel;Placebo Tablets
6 Randomized Trial to Evaluate Suppressive Effect of High-Dose Valacyclovir Versus Once-Daily Valacyclovir on Persons With HSV-2 Completed NCT01346475 Phase 4 valacyclovir;Valacyclovir
7 Trial to Study the Effect of Dose of Herpes Simplex Virus-2 (HSV-2) Suppressive Therapy on HSV and HIV Completed NCT00527618 Phase 4 valacyclovir;acyclovir
8 Randomized Trial to Evaluate Suppressive Effect of High-Dose Acyclovir Versus Once-Daily Valacyclovir on Persons With HSV-2 Completed NCT00362297 Phase 4 acyclovir;valacyclovir
9 VALTREX(Valacyclovir) Once Daily for Viral Shedding In Subjects Newly Diagnosed With HSV-2 Completed NCT00306293 Phase 4 valacyclovir
10 A Randomized Trial to Evaluated the Suppressive Effect of Acyclovir on Rapidly Cleared HSV-2 Reactivation Completed NCT00723229 Phase 4 acyclovir
11 VALTREX Once Daily For Viral Shedding In Herpes Simplex Virus 2 (HSV-2) Seropositive Subjects. VALTREX® Tablet is a Trademark of GlaxoSmithKline Group of Companies. Completed NCT00116844 Phase 4 Valaciclovir
12 A Randomized Controlled Trial of Acyclovir Among HIV and HSV-2 Co-Infected Women, Chiang Rai, Thailand Completed NCT00362596 Phase 4 acyclovir
13 Asymptomatic Bacterial Vaginosis and Herpes Simplex Virus Type 2 (BV/HSV-2) Shedding Study Completed NCT00464542 Phase 4 Metronidazole
14 Effect of HSV-2 Suppressive Therapy on Sexual Behavior Active, not recruiting NCT00495716 Phase 4 acyclovir;acyclovir
15 A Clinical Research Study For The Suppression And Treatment Of Genital Herpes Infection In HIV-Infected Persons Terminated NCT00079911 Phase 4 valacyclovir hydrochloride
16 A Study of Valacyclovir as Treatment for Genital Herpes Simplex Virus in HIV-Infected Patients Unknown status NCT00005663 Phase 3 Valacyclovir hydrochloride
17 Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and the Community Unknown status NCT00124878 Phase 3
18 Efficacy and Safety of Famciclovir 1-day Treatment Compared to 3-day Treatment With Valacyclovir in Adults With Recurrent Genital Herpes Completed NCT00306787 Phase 3 Famciclovir;Valacyclovir;Placebo matching famciclovir;Placebo matching valacyclovir
19 Efficacy and Safety of Oral Famciclovir in Patients With Active Recurrent Genital Herpes Completed NCT00171990 Phase 3 Famciclovir
20 Efficacy of Oral Famciclovir 125mg Comparing to Aciclovir 200 mg Treatment in Patients With Active Recurrent Genital Herpes Completed NCT01281007 Phase 3 Famciclovir;Aciclovir
21 Safety of a Herpes Simplex Candidate Vaccine (gD2t) With MPL and Its Efficacy to Prevent Genital Herpes Disease Completed NCT00699764 Phase 3
22 HerpeVac Trial for Young Women Completed NCT00057330 Phase 3
23 A Study of Acyclovir to Help Prevent HIV Infection in People With Genital Herpes Completed NCT00076232 Phase 3 Acyclovir;Acyclovir placebo
24 Safety Evaluation of Herpes Simplex Candidate Vaccine (gD2t) With Adjuvant in HSV Seropositive / Seronegative Subjects Completed NCT00698568 Phase 3
25 Herpes Simplex Virus Type 2 (HSV-2) Suppression to Prevent HIV Transmission Completed NCT00194519 Phase 3 Generic acyclovir;Placebo
26 Valaciclovir to Prevent Transmission of Herpes Simplex Virus Completed NCT00001649 Phase 3 Valaciclovir
27 Open-label Study of ASP2151 in Herpes Simplex Patients Completed NCT02209324 Phase 3 ASP2151
28 Trial to Evaluate PRO 2000/5 Gels for the Prevention of Vaginally Acquired HIV Infection Completed NCT00262106 Phase 3 PRO 2000/5;Placebo
29 Episodic Acyclovir Therapy for Genital Ulcers Completed NCT00164424 Phase 2, Phase 3 Acyclovir
30 Can Valacyclovir Delay the Need for Initiation of Human Immunodeficiency Virus (HIV) Treatment in HIV-infected Individuals? Active, not recruiting NCT00860977 Phase 3 valacyclovir;Placebo
31 Effect of Male Circumcision on HIV Incidence (ANRS 1265) Terminated NCT00122525 Phase 3
32 A Study With ASP2151 in Subjects With Recurrent Episodes of Genital Herpes Completed NCT00486200 Phase 2 ASP2151;valacyclovir;Placebo
33 Randomised Controlled Trial Assessing the Impact of Genital Herpes Suppressive Therapy on HIV Shedding Completed NCT00158509 Phase 2 Valacyclovir
34 Biological Efficacy Study of HerpV Vaccine With QS-21 to Treat Subjects With Recurrent Genital Herpes Completed NCT01687595 Phase 2 HerpV and QS-21;Placebo
35 Evaluating New Formulation of Therapeutic HSV-2 Vaccine Completed NCT02515175 Phase 2 Placebo
36 Safety and Efficacy Trial of DNA Vaccines to Treat Genital Herpes in Adults Completed NCT02030301 Phase 1, Phase 2
37 Safety and Efficacy Study for a New Antiviral Drug to Treat Genital Herpes Type 2 Completed NCT01047540 Phase 2 AIC316;AIC316;AIC316;AIC316;Placebo
38 Dose Ranging Safety and Efficacy of Therapeutic HSV-2 Vaccine Completed NCT02114060 Phase 2
39 Rollover Trial for Placebo Subjects Previously Enrolled Into GEN-003-002 Study Completed NCT02300142 Phase 2
40 Safety and Immunogenicity Study of Therapeutic HSV-2 Vaccine Completed NCT01667341 Phase 1, Phase 2
41 Retention and Duration of Activity of SPL7013 (VivaGel®) After Vaginal Dosing. Completed NCT00740584 Phase 1, Phase 2 3% SPL7013 Gel (VivaGel)
42 Anti-Herpetic Treatment of Genital Ulcer : Effect on HIV & Herpes Shedding (ANRS 1212) Completed NCT00158483 Phase 2 Acyclovir (ACV)
43 Acyclovir to Treat Patients Co-infected With HIV and Herpes Viruses in Uganda Completed NCT00405821 Phase 2 Acyclovir;Placebo
44 HSV-2 Suppression to Reduce Maternal HIV-1 RNA Levels During Pregnancy and Breastfeeding Completed NCT00530777 Phase 2 valacyclovir;placebo
45 Maintenance Dose Study of GEN-003 in Subjects With Genital Herpes Infection Active, not recruiting NCT03146403 Phase 2
46 Safety and Efficacy Study of Herpes Simplex Virus Type 2 (HSV-2) Therapeutic DNA Vaccine Active, not recruiting NCT02837575 Phase 2
47 A Study to Investigate the Efficacy, Safety and Tolerability of PEG in Patients With Genital Herpes Terminated NCT01765114 Phase 2 PEG-Formulation
48 Safety and Efficacy Comparator Trial of a New Drug Against Genital Herpes Terminated NCT01658826 Phase 2 AIC316;Valacyclovir
49 Safety Study of HSV2 DNA Vaccine to Treat Patients With Recurrent Genital Herpes Caused by HSV-2 Completed NCT00274300 Phase 1
50 Trial Evaluating Safety, Tolerability and Immune Response of AG-707 Completed NCT00231049 Phase 1 AG-707

Search NIH Clinical Center for Genital Herpes

Inferred drug relations via UMLS 69 / NDF-RT 48 :

Cochrane evidence based reviews: herpes genitalis

Genetic Tests for Genital Herpes

Anatomical Context for Genital Herpes

MalaCards organs/tissues related to Genital Herpes:

Testes, T Cells, Cervix, Skin, B Cells, Nk Cells, Myeloid

Publications for Genital Herpes

Articles related to Genital Herpes:

(show top 50) (show all 592)
id Title Authors Year
Dorsal longitudinal foreskin cut is associated with reduced risk of HIV, syphilis and genital herpes in men: a cross-sectional study in Papua New Guinea. ( 28406272 )
2017 European guidelines for the management of genital herpes. ( 28836892 )
Comparison of Acyclovir and Multistrain Lactobacillus brevis in Women with Recurrent Genital Herpes Infections: a Double-Blind, Randomized, Controlled Study. ( 28852985 )
A trivalent subunit antigen glycoprotein vaccine as immunotherapy for genital herpes in the guinea pig genital infection model. ( 28481687 )
Serologic Screening for Genital Herpes Infection: Recommendation Statement. ( 28671418 )
A Comparative Analysis of Polymerase Chain Reaction and Direct Fluorescent Antibody Test for Diagnosis of Genital Herpes. ( 28042218 )
Therapeutic Vaccine for Genital Herpes Simplex Virus-2 Infection: Findings From a Randomized Trial. ( 28329211 )
First-episode genital herpes: interventions for men and women. ( 28120659 )
Cutting Edge: Genetic Association between IFI16 Single Nucleotide Polymorphisms and Resistance to Genital Herpes Correlates with IFI16 Expression Levels and HSV-2-Induced IFN-I^ Expression. ( 28893956 )
Serologic Screening for Genital Herpes Infection. ( 28671417 )
Genital herpes. ( 28619732 )
A model of genital herpes simplex virus Type 1 infection in Rhesus Macaques. ( 28748667 )
Extensive and refractory genital herpes in human immunodeficiency virus-infected patient successfully treated with imiquimod: Case report and literature review. ( 28164895 )
Genital Herpes Infection in an Adolescent with Diabetes Mellitus. ( 28891491 )
Leflunomide in the Treatment of a Pseudotumoral Genital Herpes Simplex Virus Infection in an HIV Patient. ( 28373917 )
Role of type-specific herpes simplex virus-1 and 2 serology as a diagnostic modality in patients with clinically suspected genital herpes: A comparative study in Indian population from a tertiary care hospital. ( 27510668 )
Attitudes and Willingness to Assume Risk of Experimental Therapy to Eradicate Genital Herpes Simplex Virus Infection. ( 27513383 )
Nasal Immunization Confers High Avidity Neutralizing Antibody Response and Immunity to Primary and Recurrent Genital Herpes in Guinea Pigs. ( 28082979 )
OASL1 deficiency promotes antiviral protection against genital herpes simplex virus type 2 infection by enhancing type I interferon production. ( 26750802 )
Metastastic vulvar squamous cell carcinoma mimicking genital herpes. ( 27752532 )
Genital Herpes: What You Should Know. ( 27281843 )
Evolution of rational vaccine designs for genital herpes immunotherapy. ( 26896782 )
In Situ Detection of Regulatory T Cells in Human Genital Herpes Simplex Virus Type 2 (HSV-2) Reactivation and Their Influence on Spontaneous HSV-2 Reactivation. ( 27117511 )
JAMA patient page: Screening for Genital Herpes. ( 27997655 )
Clinical study of Gene-Eden-VIR/Novirin in genital herpes: suppressive treatment safely decreases the duration of outbreaks in both severe and mild cases. ( 27766602 )
Genital Herpes. ( 27959656 )
Intravaginal Zinc Oxide Tetrapod Nanoparticles as Novel Immunoprotective Agents against Genital Herpes. ( 27183601 )
Current Concepts for Genital Herpes Simplex Virus Infection: Diagnostics and Pathogenesis of Genital Tract Shedding. ( 26561565 )
Integrative pharmacokinetic-pharmacodynamic modeling and simulation of amenamevir (ASP2151) for treatment of recurrent genital herpes. ( 27461507 )
Unfortunate synergy between HIV and genital herpes. ( 26884529 )
Herpes simplex virus: 'to disclose or not to disclose.' An exploration of the multi-disciplinary team's role in advising patients about disclosure when diagnosed with genital herpes simplex virus. ( 27582307 )
Genital Herpes. ( 27959657 )
A Recommendation Against Serologic Screening for Genital Herpes Infection-What Now? ( 27997636 )
Interventions for men and women with their first episode of genital herpes. ( 27575957 )
Genital Herpes: Insights into Sexually Transmitted Infectious Disease. ( 28357380 )
Serologic Screening for Genital Herpes Infection: US Preventive Services Task Force Recommendation Statement. ( 27997659 )
CLINICAL PRACTICE. Genital Herpes. ( 27532832 )
Effects of a traditional Chinese medicine, Longdanxiegan formula granule, on Toll-like receptor pathway in female guinea pigs with recurrent genital herpes. ( 27125405 )
Optimal management of genital herpes: current perspectives. ( 27358569 )
First HSV-1 non primary genital herpes in two patients. ( 27018573 )
Genital herpes. ( 27109044 )
The occurrence of herpes simplex viruses 1 and 2 in skin and mucosal lesions in patients with suspicion of genital herpes. ( 28146623 )
Screening for Genital Herpes: What Is Not to Be Done. ( 27997634 )
Clinical study in genital herpes: natural Gene-Eden-VIR/Novirin versus acyclovir, valacyclovir, and famciclovir. ( 27621592 )
Collaboration with a midwife in the care of a pregnant patient with recurrent genital herpes simplex virus. ( 27412208 )
False-negative type-specific glycoprotein G antibody responses in STI clinic patients with recurrent HSV-1 or HSV-2 DNA positive genital herpes, The Netherlands. ( 26755775 )
Genital Herpes: A Review. ( 27281837 )
Serologic Screening for Genital Herpes: An Updated Evidence Report and Systematic Review for the US Preventive Services Task Force. ( 27997660 )
Protection from genital herpes disease, seroconversion and latent infection in a non-lethal murine genital infection model by immunization with an HSV-2 replication-defective mutant virus. ( 26609935 )
Medroxyprogesterone acetate and levonorgestrel increase genital mucosal permeability and enhance susceptibility to genital herpes simplex virus type 2 infection. ( 27007679 )

Variations for Genital Herpes

Expression for Genital Herpes

Search GEO for disease gene expression data for Genital Herpes.

Pathways for Genital Herpes

Pathways related to Genital Herpes according to GeneCards Suite gene sharing:

(show all 25)
id Super pathways Score Top Affiliating Genes
Show member pathways
13.17 CCL5 IL10 IL18 IL4 TLR2 TLR9
Show member pathways
12.66 CCL5 IL10 TLR2 TLR9
Show member pathways
12.6 CCL5 IL18 IL4 TLR2 TLR9
Show member pathways
12.34 IL10 IL18 IL4 TBX21 TLR2
5 12.13 CCL5 IL10 IL4 TBX21 TLR2 TLR9
Show member pathways
12.06 IL10 IL4 TLR2
7 12.03 IL10 IL18 TLR2 TLR9
Show member pathways
11.98 IL4 TLR2 TLR9
Show member pathways
11.96 IL10 IL18 IL4
10 11.8 IL10 IL18 IL4
Show member pathways
11.79 IL18 IL4 TBX21
Show member pathways
11.72 IL4 TLR2 TLR9
13 11.65 CCL5 IL18 TLR2
14 11.57 IL10 IL18 IL4 TBX21
15 11.47 IL10 IL4 TLR2 TLR9
Show member pathways
11.38 IL10 IL18 TBX21 TLR2 TLR9
17 11.25 CCL5 IL10 IL18 IL4
18 11.18 IL10 IL18 TLR9
19 11.11 IL18 IL4 TBX21
20 11.1 IL10 IL4
21 11.06 IL18 TBX21
22 11.03 CCL5 IL10 IL18 IL4
23 11.02 IL10 IL4
24 11 IL18 TLR2
25 10.71 ACKR1 IL10 IL18 TLR2 TLR9

GO Terms for Genital Herpes

Cellular components related to Genital Herpes according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 APOE CCL5 IFNL4 IL10 IL18 IL4

Biological processes related to Genital Herpes according to GeneCards Suite gene sharing:

(show all 35)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.99 IL10 IL18 IL4 T TLR2 TLR9
2 immune response GO:0006955 9.89 CCL5 IL10 IL18 IL4 TLR2
3 positive regulation of inflammatory response GO:0050729 9.72 IL18 TLR2 TLR9
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.71 CCL5 IL18 IL4
5 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.67 TLR2 TLR9
6 positive regulation of activated T cell proliferation GO:0042104 9.66 IL18 IL4
7 negative regulation of endothelial cell apoptotic process GO:2000352 9.66 IL10 IL4
8 triglyceride homeostasis GO:0070328 9.65 APOE IL18
9 positive regulation of interleukin-8 production GO:0032757 9.65 TLR2 TLR9
10 positive regulation of interferon-beta production GO:0032728 9.65 TLR2 TLR9
11 negative regulation of interleukin-6 production GO:0032715 9.64 IL10 TLR9
12 positive regulation of interleukin-12 production GO:0032735 9.64 TLR2 TLR9
13 defense response to protozoan GO:0042832 9.63 IL10 IL4
14 negative regulation of nitric oxide biosynthetic process GO:0045019 9.63 IL10 IL4
15 positive regulation of chemokine production GO:0032722 9.62 TLR2 TLR9
16 microglial cell activation GO:0001774 9.62 IL4 TLR2
17 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.61 TLR2 TLR9
18 I-kappaB phosphorylation GO:0007252 9.61 TLR2 TLR9
19 regulation of cytokine secretion GO:0050707 9.6 TLR2 TLR9
20 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.59 IL18 TLR9
21 positive regulation of isotype switching to IgG isotypes GO:0048304 9.58 IL4 TBX21
22 regulation of T cell activation GO:0050863 9.58 CCL5 IFNL4
23 positive regulation of MHC class II biosynthetic process GO:0045348 9.56 IL10 IL4
24 lipopolysaccharide-mediated signaling pathway GO:0031663 9.54 CCL5 IL18 TLR2
25 negative regulation of interleukin-8 production GO:0032717 9.52 IL10 TLR9
26 positive regulation of interleukin-10 production GO:0032733 9.5 IL4 TLR2 TLR9
27 regulation of isotype switching GO:0045191 9.48 IL10 IL4
28 positive regulation of interleukin-18 production GO:0032741 9.46 TLR2 TLR9
29 positive regulation of NF-kappaB import into nucleus GO:0042346 9.43 IL18 TLR2 TLR9
30 inflammatory response GO:0006954 9.43 ACKR1 CCL5 IL10 IL18 TLR2 TLR9
31 positive regulation of toll-like receptor signaling pathway GO:0034123 9.4 TLR2 TLR9
32 response to molecule of bacterial origin GO:0002237 9.33 IL10 TLR2 TLR9
33 positive regulation of immunoglobulin production GO:0002639 9.27 IL4
34 tumor necrosis factor production GO:0032640 9.13 TLR9
35 type 2 immune response GO:0042092 8.8 IL10 IL18 IL4

Molecular functions related to Genital Herpes according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CCL5 IFNL4 IL10 IL18 IL4

Sources for Genital Herpes

9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
52 Novoseek
55 OMIM via Orphanet
59 PubMed
66 SNOMED-CT via Orphanet
68 Tocris
70 UMLS via Orphanet
Loading form....