Genital Herpes malady

MedlinePlus: Genital herpes is a sexually transmitted disease (std) caused by a herpes simplex virus (hsv). it can cause sores on your genital or rectal area, buttocks, and thighs. you can get it from having sex, even oral sex. the virus can spread even when sores are not present. mothers can also infect their babies during childbirth. symptoms of herpes are called outbreaks. you usually get sores near the area where the virus has entered the body. they turn into blisters, become itchy and painful, and then heal. sometimes people do not know they have herpes because they have no symptoms or very mild symptoms. the virus can be more serious in newborn babies or in people with weak immune systems. most people have outbreaks several times a year. over time, you get them less often and the symptoms become milder. the virus stays in your body for life. medicines do not cure genital herpes, but they can help your body fight the virus. this can help lessen symptoms, decrease outbreaks, and lower the risk of passing the virus to others. correct usage of latex condoms can reduce, but not eliminate, the risk of catching or spreading herpes. nih: national institute of allergy and infectious diseases²³

MalaCards: Genital Herpes, also known as other genital herpes, is related to herpes simplex and vaginitis, and has symptoms including sores, fever and swollen gl. An important gene associated with Genital Herpes is DARC (Duffy blood group, chemokine receptor), and among its related pathways are Autoimmune thyroid disease and Toll-like receptor signaling pathway. The drugs acyclovir and interferon alfa-2b and the compounds sb 203580 and ionomycin have been mentioned in the context of this disorder. Affiliated tissues include genital system, rectum and skin.

Disease Ontology: A herpes simplex that results in infection located in genital system, or located in rectum, has material basis in human herpesvirus 1 or has material basis in human herpesvirus 2, which is transmitted by sexual contact. the infection has symptom sores, has symptom fever, and has symptom swollen glands.⁶

CDC: Genital herpes is a common STD, and most people with genital herpes infection do not know they have it.²

Wikipedia: Herpes genitalis (or genital herpes) refers to a genital infection by Herpes simplex virus.⁴⁴ more...

Aliases & Descriptions:

genital herpes 6 8 32 23 43 other genital herpes 6 43 genital herpes simplex nos (disorder) 6 genital herpes unspecified (disorder) 6 genital herpes simplex (disorder) 6 genital herpes unspecified 6

virus-genital herpes 6 herpes genitalis 6 herpes genitalia 6 venereal herpes 6

Diseases related to genital herpes by text searches and GeneDecks gene sharing:

(show top 50)    (show all 186)

id	Related Disease	Score	Top Affiliating Genes
1	herpes simplex	28.5	T, IL4, APOE, CCL3, CCL5, IFNA1
2	vaginitis	25.3	IL4, APOE, CCL3, CCL5, IFNA1, DARC
3	respiratory syncytial virus infectious disease	13.2	CCL3, CCL5
4	mast-cell leukemia	13.1	CCL3, CCL5
5	african tick-bite fever	13.1	CCL3, CCL5
6	idiopathic myopathy	13.0	CCL5, HLA-B
7	herpetic keratitis	13.0	IFNA1, DARC, DEFB4A
8	tropical spastic paraparesis	12.9	T, CCL3, HLA-B
9	spastic paraparesis	12.9	T, CCL3, HLA-B
10	pulmonary plasma cell granuloma	12.8	CCL3, CCL5, TLR2
11	chromoblastomycosis	12.8	IL4, CCL3
12	anterior uveitis	12.7	CCL5, HLA-B, TLR2
13	alcoholic hepatitis	12.7	CCL3, CCL5, TLR2
14	fetal parainfluenza virus type 3 syndrome	12.7	CCL3, CCL5, IFNA1
15	periodontal disease	12.7	CCL3, TLR2, DEFB4A
16	intrinsic asthma	12.7	IL4, CCL5
17	htlv-1 associated myelopathy	12.7	CCL3, IFNA1, HLA-B
18	alexithymia	12.7	IL4, CCL3
19	lepromatous leprosy	12.6	IL4, TLR2
20	behcet's disease	12.6	CCL3, IFNA1, HLA-B
21	vulvovaginal candidiasis	12.6	IL4, DEFB4A
22	localized scleroderma	12.6	IL4, CCL5, DEFB4A
23	cork-handlers' disease	12.5	CCL3, CCL5, TLR2, DEFB4A
24	periapical granuloma	12.5	IL4, CCL3, CCL5
25	duodenal ulcer	12.5	CCL5, HLA-B, TLR2, DEFB4A
26	folliculitis	12.5	IL4, CCL5, DEFB4A
27	paine syndrome	12.5	CCL3, CCL5, HLA-B
28	bacterial vaginosis	12.4	IL4, TLR2, DEFB4A
29	stevens-johnson syndrome	12.4	IL4, CCL5, HLA-B
30	pulmonary tuberculosis	12.4	IL4, CCL3, TLR2
31	wheat allergic reaction	12.3	IL4, CCL3, CCL5
32	haemophilus influenzae	12.3	HLA-B, TLR2, DEFB4A
33	spondylarthropathy	12.3	IL4, HLA-B, TLR2
34	autoimmune hemolytic anemia	12.3	T, IL4, IFNA1
35	osteomyelitis	12.3	IL4, CCL5, TLR2
36	osteolysis	12.2	IL4, CCL3, TLR2
37	crohn's disease	12.2	T, IL4, TLR2, DEFB4A
38	alopecia areata	12.2	T, IL4, CCL5, HLA-B
39	mycobacterial infection	12.2	IL4, CCL3, TLR2, DEFB4A
40	leptospirosis	12.2	IL4, HLA-B, TLR2
41	pulmonary hypertension	12.1	APOE, CCL3, CCL5, HLA-B, NFU1
42	serous glue ear	12.1	IL4, CCL5, IFNA1
43	alopecia	12.1	T, IL4, CCL5, HLA-B
44	churg-strauss syndrome	12.1	IL4, IFNA1, HLA-B
45	acquired immunodeficiency syndrome	12.1	APOE, CCL3, IFNA1, HLA-B
46	hairy cell leukemia	12.1	T, IL4, IFNA1, TBX21
47	brucellosis	12.1	IL4, IFNA1, HLA-B
48	eczema	12.1	IL4, CCL5, TLR2, DEFB4A
49	aspergillosis	12.1	IL4, CCL3, CCL5, TLR2
50	atopic dermatitis	12.1	IL4, CCL5, TLR2, DEFB4A

Symptoms: sores, fever, swollen gl.⁶

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 acyclovir, acyclovir sodium, foscarnet, foscarnet sodium hexahydrate, interferon alfa-2b, valacyclovir, valacyclovir hydrochloride

MalaCards organs/tissues related to genital herpes:

²²

FMA organs/tissues related to genital herpes:

¹¹

Articles related to genital herpes:

(show all 11)

id	Title	Authors	Year	Affiliating Genes
1	A 3'-untranslated region polymorphism in the TBX21 gene encoding T-bet is a risk factor for genital herpes simplex virus type 2 infection in humans. (18753235)	Svensson A.... Eriksson K.	2008	T, TBX21
2	Apolipoprotein E-epsilon 4 and recurrent genital herpes in individuals co-infected with herpes simplex virus type 2 and HIV. (18708484)	Jayasuriya A.N.... White D.J.	2008	APOE
3	Polymorphisms in TLR2 are associated with increased viral shedding and lesional rate in patients with genital herpes simplex virus Type 2 infection. (17624834)	Bochud P.Y.... Wald A.	2007	TLR2
4	Effect of Huangbai Liquid on expression of human beta-defensin-2 mRNA in skin lesions of patients with recurrent genital herpes (17205827)	Ren X.L.... Chen J.G.	2006	DEFB4A
5	Isopentenyl pyrophosphate-reactive Vgamma9Vdelta 2 T helper 1-like cells are the major gammadelta T cell subset recovered from lesions of patients with genital herpes. (15243921)	Verjans G.M.... Osterhaus A.M.	2004	IL4, CCL5, CCL3
6	Analysis of the interferon status and cytokine profile in patients with genital herpes. (12687260)	Mezentseva M.V.... Ershov F.I.	2002	IFNA1
7	CD8 CTL from genital herpes simplex lesions: recognition of viral tegument and immediate early proteins and lysis of infected cutaneous cells. (11238653)	Koelle D.M.... Corey L.	2001	NXF1
8	High frequency of CD8+ cytotoxic T-lymphocyte precurs ors specific for herpes simplex viruses in persons with genital herpes. (8892947)	Posavad C.M.... Corey L.	1996	HLA-B
9	Immunization with recombinant varicella-zoster virus expressing herpes simplex virus type 2 glycoprotein D reduces the severity of genital herpes in guinea pigs. (7494331)	Heineman T.C.... Cohen J.	1995	DARC
10	Passive immunization of the vagina protects mice against vaginal transmission of genital herpes infections. (8158042)	Whaley K.J.... Cone R.A.	1994	DARC
11	Placebo-controlled trial of vaccination with recombinant glycoprotein D of herpes simplex virus type 2 for immunotherapy of genital herpes. (7911177)	Straus S.E.... Adair S.F.	1994	DARC

Genes related to genital herpes according to GeneCards:

(show all 21)

id	Symbol	Description	Score	GeneCards Section Context
1	DARC	Duffy blood group, chemokine receptor	11.0	Publications
2	ZBTB32	zinc finger and BTB domain containing 32	11.0
3	MRPL36	mitochondrial ribosomal protein L36	11.0
4	FICD	FIC domain containing	11.0	Disorders
5	YY2	YY2 transcription factor	11.0
6	T	T, brachyury homolog (mouse)	11.0	Publications
7	NXF1	nuclear RNA export factor 1	11.0	Publications
8	TBX21	T-box 21	11.0	Publications
9	NFU1	NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)	11.0
10	TUBGCP4	tubulin, gamma complex associated protein 4	11.0
11	DEFB4A	defensin, beta 4A	11.0	Publications
12	ATAD2	ATPase family, AAA domain containing 2	11.0
13	CCL5	chemokine (C-C motif) ligand 5	11.0	Publications
14	CCL3	chemokine (C-C motif) ligand 3	11.0	Publications
15	FCHSD2	FCH and double SH3 domains 2	11.0
16	TLR2	toll-like receptor 2	11.0	Publications
17	HLA-B	major histocompatibility complex, class I, B	11.0	Publications
18	NKAIN2	Na+/K+ transporting ATPase interacting 2	11.0
19	IL4	interleukin 4	11.0	Publications
20	IFNA1	interferon, alpha 1	11.0	Publications
21	APOE	apolipoprotein E	11.0	Publications

Pathways related to genital herpes according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Autoimmune thyroid disease20	8.6	IL4, IFNA1, HLA-B
2	Toll-like receptor signaling pathway20	8.3	CCL3, CCL5, IFNA1, TLR2

Compounds related to genital herpes according to GeneDecks:

(show all 41)

id	Compound	Score	Top Affiliating Genes
1	sb 20358032 42	11.5	CCL5
2	ionomycin32	10.4	CCL3
3	endotoxin32	10.2	DEFB4A, CCL3
4	ivermectin32 9 9	11.6	IL4, CCL5
5	ccl432	9.6	CCL3, CCL5, TLR2
6	mip 1alpha32	9.6	IL4, CCL3, CCL5
7	gm-csf32	9.5	CCL5, CCL3, IL4
8	anaphylatoxin32	9.5	IL4, CCL3, CCL5
9	peptidoglycan32	9.5	CCL3, CCL5, TLR2, DEFB4A
10	loxoribine32	9.5	IFNA1, TLR2
11	amphotericin b32	9.5	IL4, CCL5, TLR2
12	sp 60012532 42	10.5	DEFB4A, TLR2, CCL5, CCL3
13	methacholine32 9 9	11.4	CCL5, CCL3, IL4
14	vegf32	9.4	APOE, CCL3, CCL5
15	tarc32	9.4	IL4, CCL3, CCL5
16	lipoteichoic acid32	9.4	DEFB4A, TLR2, HLA-B, CCL3
17	betaseron32	9.3	IL4, IFNA1
18	il 1032	9.2	TLR2, CCL5, CCL3, IL4
19	glatiramer acetate32 9 9	11.1	IFNA1, CCL5, IL4
20	pdtc32	9.1	CCL5, CCL3, IL4
21	ritonavir32 34 9 9	12.1	IL4, APOE, CCL3, CCL5
22	ursodeoxycholic acid32 9 18 9	12.0	APOE, IFNA1, HLA-B
23	ccl332	9.0	CCL3, CCL5, IFNA1, TLR2
24	ribonucleic acid32	8.9	CCL3, CCL5, HLA-B, TLR2
25	ribavirin32 34 9 9	11.9	IL4, CCL3, IFNA1
26	histamine32 18	9.8	DEFB4A, TLR2, CCL5, CCL3, IL4
27	neopterin32	8.8	IFNA1, CCL3, IL4
28	simvastatin32 34 42 9 18 9	13.7	TLR2, CCL5, CCL3, APOE, IL4
29	bleomycin32 9 9	10.5	IFNA1, CCL3, APOE, IL4
30	pge232	8.5	TLR2, HLA-B, CCL5, CCL3, IL4
31	poly(i-c)32	8.4	TLR2, IFNA1, CCL5, CCL3, IL4
32	polyinosinic-polycytidylic acid32	8.2	TLR2, HLA-B, IFNA1, CCL3, IL4
33	chloroquine32 34 9 9	11.2	IL4, APOE, IFNA1
34	actinomycin d32	8.1	TLR2, IFNA1, CCL3, APOE, IL4
35	cysteine32	8.0	DEFB4A, TLR2, NFU1, CCL5, CCL3, APOE
36	tacrolimus32 34 9 9	10.9	TLR2, HLA-B, IFNA1, CCL5, CCL3, IL4
37	alanine32	7.9	TLR2, DARC, IFNA1, CCL5, CCL3, APOE
38	cycloheximide32	7.8	TLR2, IFNA1, CCL5, CCL3, APOE, IL4
39	dexamethasone32 42 34 9 9	11.6	DEFB4A, TLR2, HLA-B, IFNA1, CCL5, CCL3
40	rantes32	7.5	IL4, DEFB4A, TLR2, DARC, HLA-B, IFNA1
41	cyclosporin a32 42	8.4	TLR2, HLA-B, IFNA1, CCL5, CCL3, APOE

Biological processes related to genital herpes according to GeneDecks:

(show all 9)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of natural killer cell chemotaxis	GO:2000503	10.0	CCL3, CCL5
2	eosinophil chemotaxis	GO:048245	9.9	CCL3, CCL5
3	lymphocyte chemotaxis	GO:048247	9.8	CCL3, CCL5
4	negative regulation by host of viral transcription	GO:043922	9.8	CCL3, CCL5
5	positive regulation of isotype switching to IgG isotypes	GO:048304	9.7	TBX21, IL4
6	response to cholesterol	GO:070723	9.7	CCL5, CCL3
7	lipopolysaccharide-mediated signaling pathway	GO:031663	9.6	CCL3, CCL5, TLR2
8	macrophage chemotaxis	GO:048246	9.5	CCL3, CCL5
9	chemotaxis	GO:006935	9.1	DEFB4A, CCL5, CCL3, IL4

Molecular functions related to genital herpes according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	CCR1 chemokine receptor binding	GO:031726	9.8	CCL3, CCL5
2	phospholipase activator activity	GO:016004	9.7	CCL3, CCL5
3	CCR5 chemokine receptor binding	GO:031730	9.5	CCL3, CCL5