MCID: GNT003
MIFTS: 53

Genital Herpes malady

Categories: Infectious diseases, Reproductive diseases

Aliases & Classifications for Genital Herpes

Aliases & Descriptions for Genital Herpes:

Name: Genital Herpes 12 52 41 3 3 3 3 14 69
Herpes Genitalis 12 42
Genital Herpes Simplex 12
Virus-Genital Herpes 12
Herpes Genitalia 12
Venereal Herpes 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8704
ICD9CM 35 054.1 054.10
MeSH 42 D006558
NCIt 47 C14364
UMLS 69 C0019342

Summaries for Genital Herpes

MedlinePlus : 41 genital herpes is a sexually transmitted disease (std) caused by a herpes simplex virus (hsv). it can cause sores on your genital or rectal area, buttocks, and thighs. you can get it from having vaginal, anal, or oral sex with someone who has it. the virus can spread even when sores are not present. mothers can also infect their babies during childbirth. symptoms of herpes are called outbreaks. you usually get sores near the area where the virus has entered the body. the sores are blisters which break and become painful, and then heal. sometimes people do not know they have herpes because they have no symptoms or very mild symptoms. the virus can be more serious in newborn babies or in people with weak immune systems. repeat outbreaks are common, especially during the first year. over time, you get them less often and the symptoms become milder. the virus stays in your body for life. there are tests that can diagnose genital herpes. there is no cure. however, medicines can help lessen symptoms, decrease outbreaks, and lower the risk of passing the virus to others. correct usage of latex condoms can reduce, but not eliminate, the risk of catching or spreading herpes. nih: national institute of allergy and infectious diseases

MalaCards based summary : Genital Herpes, also known as herpes genitalis, is related to herpes simplex and herpes simplex encephalitis, and has symptoms including sores, fever and swollen gl. An important gene associated with Genital Herpes is ACKR1 (Atypical Chemokine Receptor 1 (Duffy Blood Group)), and among its related pathways/superpathways are Influenza A and Th17 cell differentiation. The drugs Tenofovir and Famciclovir have been mentioned in the context of this disorder. Affiliated tissues include testes, t cells and skin, and related phenotypes are digestive/alimentary and immune system

Disease Ontology : 12 A herpes simplex that results_in infection located in genital system, or located in rectum, has material basis in Human herpesvirus 1 or has material basis in Human herpesvirus 2, which is transmitted_by sexual contact. The infection has symptom sores, has symptom fever, and has symptom swollen glands.

Wikipedia : 71 Genital herpes is a genital infection caused by the herpes simplex virus (HSV). Most individuals... more...

Related Diseases for Genital Herpes

Diseases related to Genital Herpes via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
id Related Disease Score Top Affiliating Genes
1 herpes simplex 11.6
2 herpes simplex encephalitis 10.9
3 tubular renal disease-cardiomyopathy syndrome 10.3 IL10 IL4
4 asymptomatic neurosyphilis 10.3 IL10 IL4
5 lagophthalmos 10.3 IL10 IL4
6 ceroid lipofuscinosis, neuronal, 3 10.2 IL10 IL4
7 diabetic angiopathy 10.2 IL10 IL4
8 conidiobolomycosis 10.2 IL10 IL4
9 tungiasis 10.2 IL10 IL4
10 vestibule of mouth cancer 10.2 IL10 IL4
11 hidradenitis suppurativa 10.2 CCL5 IL10
12 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.2 IL10 IL4
13 goat milk allergy 10.2 IL10 IL4
14 indian plum allergy 10.2 IL10 IL4
15 nguyen syndrome 10.2 IL10 TLR2
16 centronuclear myopathy 5 10.2 IL10 IL4
17 cerebral primitive neuroectodermal tumor 10.2 CCL5 IL4
18 osteodysplasty precocious of danks mayne and kozlowski 10.2 CCL5 IL10 IL4
19 amyotrophic lateral sclerosis-parkinsonism/dementia complex 10.2 CCL5 IL10
20 primary optic atrophy 10.2 CCL5 TLR2
21 nonspecific interstitial pneumonia 10.2 ACKR1 IL10 IL4
22 apricot allergy 10.2 CCL5 IL4
23 pulmonary tuberculosis 10.1 CCL5 IL10 IL4
24 spontaneous ocular nystagmus 10.1 CCL5 IL10 IL4
25 lipid storage disease 10.1 CCL5 IL10 IL4
26 acute chest syndrome 10.1 CCL5 IL10 IL4
27 non-gestational choriocarcinoma 10.1 CCL5 IL10 TBX21
28 luminal breast carcinoma 10.1 IL18 IL4
29 nervous system cancer 10.1 CCL5 IL10 IL4
30 facial paralysis 10.1 IL10 IL18
31 cutaneous fibrous histiocytoma 10.1 CCL5 IL4
32 mediastinum neurofibroma 10.1 CCL5 IL10 IL4
33 exophthalmos 10.1 CCL5 IL10 IL4
34 congenital hypothyroidism 10.1 IL10 IL4 TLR2
35 abnormal retinal correspondence 10.1 IL10 IL4 TLR2
36 thymus adenosquamous carcinoma 10.1 CCL5 IL10 IL4
37 peripheral artery disease 10.1 IL10 IL4 TLR2
38 dengue hemorrhagic fever 10.1 IL10 IL4 TLR2
39 inflammatory bowel disease 2 10.1 IL10 IL4 TLR2
40 liver inflammatory pseudotumor 10.1 IL10 IL4 TLR2
41 hallucinogen dependence 10.1 IL10 IL4 TLR2
42 keratomalacia 10.1 IL10 IL4 TLR2
43 foodborne botulism 10.1 IL10 IL4 TLR2
44 trachea leiomyoma 10.1 CCL5 IL4
45 mansonelliasis 10.1 CCL5 IL10 TLR2
46 optic nerve hypoplasia 10.1 ACKR1 IL10 TLR2
47 erythematosquamous dermatosis 10.1 IL10 IL4 TLR2
48 acute myeloid leukemia with recurrent genetic anomaly 10.1 IL10 IL18 IL4
49 atrial septal defect 6 10.1 IL10 IL4 TLR2
50 rectum squamous cell carcinoma 10.0 CCL5 IL10 TLR2

Comorbidity relations with Genital Herpes via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Genital Herpes:



Diseases related to Genital Herpes

Symptoms & Phenotypes for Genital Herpes

Symptoms:

12
  • sores
  • fever
  • swollen gl

UMLS symptoms related to Genital Herpes:


fever, pelvic pain, pruritus

MGI Mouse Phenotypes related to Genital Herpes:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.7 APOE IL10 IL18 IL4 T TBX21
2 immune system MP:0005387 9.56 CCL5 IL10 IL18 IL4 TBX21 TLR2
3 integument MP:0010771 9.1 APOE IL10 IL18 IL4 T TLR2

Drugs & Therapeutics for Genital Herpes

Drugs for Genital Herpes (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 53)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tenofovir Approved, Investigational Phase 4 147127-20-6 464205
2
Famciclovir Approved Phase 4,Phase 3 104227-87-4 3324
3
Metronidazole Approved Phase 4 443-48-1 4173
4 Acyclovir Phase 4,Phase 3,Phase 2,Phase 1
5 valacyclovir Phase 4,Phase 3,Phase 2,Phase 1
6 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
7 Antiviral Agents Phase 4,Phase 3,Phase 2,Phase 1
8 Nucleic Acid Synthesis Inhibitors Phase 4
9 Anti-HIV Agents Phase 4
10 2-Aminopurine Phase 4,Phase 3
11 Antimetabolites Phase 4,Phase 3
12 Anti-Retroviral Agents Phase 4
13 Reverse Transcriptase Inhibitors Phase 4
14 Antiparasitic Agents Phase 4
15 Antiprotozoal Agents Phase 4
16
Halofantrine Approved Phase 3 69756-53-2 37393
17 Monophosphoryl lipid A Phase 3
18 interferons Phase 3,Phase 2
19 Adjuvants, Immunologic Phase 3,Phase 2
20 Aluminum sulfate Phase 3
21 Vaccines Phase 3,Phase 2,Phase 1
22 Anti-Bacterial Agents Phase 3,Phase 1,Phase 2
23 Protective Agents Phase 3
24 Interferon Inducers Phase 3,Phase 2
25 Krestin Phase 3,Phase 2
26 Radiation-Protective Agents Phase 3
27 Antibiotics, Antitubercular Phase 3,Phase 1,Phase 2
28
Ganciclovir Approved, Investigational Phase 2 82410-32-0 3454
29
Imiquimod Approved, Investigational Phase 2 99011-02-6 57469
30 Ganciclovir triphosphate Phase 2
31 Freund's Adjuvant Phase 2
32 Anti-Infective Agents, Local Phase 2
33
QS 21 Phase 2 141256-04-4
34 Pharmaceutical Solutions Phase 1, Phase 2
35 Lecithin Nutraceutical Phase 2
36
Heroin Approved, Illicit 561-27-3 5462328
37
Methadone Approved 76-99-3 4095
38
Guaifenesin Approved, Vet_approved 93-14-1 3516
39
Emtricitabine Approved, Investigational 143491-57-0 60877
40 Analgesics
41 Chlorpheniramine, phenylpropanolamine drug combination
42 Narcotics
43 Analgesics, Opioid
44 Peripheral Nervous System Agents
45 Respiratory System Agents
46 Antitussive Agents
47 Central Nervous System Depressants
48 HIV Integrase Inhibitors
49 Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination
50 Integrase Inhibitors

Interventional clinical trials:

(show top 50) (show all 101)
id Name Status NCT ID Phase
1 Patient-initiated Episodic Treatment of Recurrent Genital Herpes in Black Patients Completed NCT00477334 Phase 4
2 A Study Comparing Daily Treatment With Valaciclovir To Placebo For Suppression Of Herpes Simplex Virus HSV-2 Genital Herpes In Newly Diagnosed Patients. VALTREX® Tablet is a Trademark of the GlaxoSmithKline Group of Companies. Completed NCT00158860 Phase 4
3 RELIEF: Randomized Episodic Versus Long-Term Suppression Experience With Famciclovir Completed NCT00219310 Phase 4
4 A Study to Evaluate the Effect of Famciclovir in Reducing Herpes Virus Shedding Completed NCT00129818 Phase 4
5 Randomized Trial to Evaluate Suppressive Effect of High-Dose Valacyclovir Versus Once-Daily Valacyclovir on Persons With HSV-2 Completed NCT01346475 Phase 4
6 Effect of Tenofovir on Genital Herpes Simplex Virus (HSV) Shedding Completed NCT01448616 Phase 4
7 Trial to Study the Effect of Dose of Herpes Simplex Virus-2 (HSV-2) Suppressive Therapy on HSV and HIV Completed NCT00527618 Phase 4
8 Randomized Trial to Evaluate Suppressive Effect of High-Dose Acyclovir Versus Once-Daily Valacyclovir on Persons With HSV-2 Completed NCT00362297 Phase 4
9 A Randomized Trial to Evaluated the Suppressive Effect of Acyclovir on Rapidly Cleared HSV-2 Reactivation Completed NCT00723229 Phase 4
10 VALTREX(Valacyclovir) Once Daily for Viral Shedding In Subjects Newly Diagnosed With HSV-2 Completed NCT00306293 Phase 4
11 VALTREX Once Daily For Viral Shedding In Herpes Simplex Virus 2 (HSV-2) Seropositive Subjects. VALTREX® Tablet is a Trademark of GlaxoSmithKline Group of Companies. Completed NCT00116844 Phase 4
12 A Randomized Controlled Trial of Acyclovir Among HIV and HSV-2 Co-Infected Women, Chiang Rai, Thailand Completed NCT00362596 Phase 4
13 Asymptomatic Bacterial Vaginosis and Herpes Simplex Virus Type 2 (BV/HSV-2) Shedding Study Completed NCT00464542 Phase 4
14 Effect of HSV-2 Suppressive Therapy on Sexual Behavior Active, not recruiting NCT00495716 Phase 4
15 A Clinical Research Study For The Suppression And Treatment Of Genital Herpes Infection In HIV-Infected Persons Terminated NCT00079911 Phase 4
16 A Study of Valacyclovir as Treatment for Genital Herpes Simplex Virus in HIV-Infected Patients Unknown status NCT00005663 Phase 3
17 Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and the Community Unknown status NCT00124878 Phase 3
18 Efficacy and Safety of Famciclovir 1-day Treatment Compared to 3-day Treatment With Valacyclovir in Adults With Recurrent Genital Herpes Completed NCT00306787 Phase 3
19 Efficacy and Safety of Oral Famciclovir in Patients With Active Recurrent Genital Herpes Completed NCT00171990 Phase 3
20 Efficacy of Oral Famciclovir 125mg Comparing to Aciclovir 200 mg Treatment in Patients With Active Recurrent Genital Herpes Completed NCT01281007 Phase 3
21 Safety of a Herpes Simplex Candidate Vaccine (gD2t) With MPL and Its Efficacy to Prevent Genital Herpes Disease Completed NCT00699764 Phase 3
22 A Study of Acyclovir to Help Prevent HIV Infection in People With Genital Herpes Completed NCT00076232 Phase 3
23 HerpeVac Trial for Young Women Completed NCT00057330 Phase 3
24 Safety Evaluation of Herpes Simplex Candidate Vaccine (gD2t) With Adjuvant in HSV Seropositive / Seronegative Subjects Completed NCT00698568 Phase 3
25 Herpes Simplex Virus Type 2 (HSV-2) Suppression to Prevent HIV Transmission Completed NCT00194519 Phase 3
26 Valaciclovir to Prevent Transmission of Herpes Simplex Virus Completed NCT00001649 Phase 3
27 Trial to Evaluate PRO 2000/5 Gels for the Prevention of Vaginally Acquired HIV Infection Completed NCT00262106 Phase 3
28 Open-label Study of ASP2151 in Herpes Simplex Patients Completed NCT02209324 Phase 3
29 Episodic Acyclovir Therapy for Genital Ulcers Completed NCT00164424 Phase 2, Phase 3
30 HSV-2 Suppression to Reduce HIV-1 Levels in HIV-1 Co-infected Persons Completed NCT00465205 Phase 3
31 HSV-2 Suppression to Reduce HIV-1 Levels in HIV-1, HSV-2 Co-infected Men. Completed NCT00378976 Phase 3
32 Effectiveness of a Community-level HIV/STD Prevention Intervention in Promoting Safer Sexual Behaviors in High-risk Populations Completed NCT00710060 Phase 3
33 Can Valacyclovir Delay the Need for Initiation of Human Immunodeficiency Virus (HIV) Treatment in HIV-infected Individuals? Active, not recruiting NCT00860977 Phase 3
34 Effect of Male Circumcision on HIV Incidence (ANRS 1265) Terminated NCT00122525 Phase 3
35 Gene Therapy in Treating Women With Refractory or Relapsed Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Peritoneal Cancer Unknown status NCT00005025 Phase 2
36 A Study With ASP2151 in Subjects With Recurrent Episodes of Genital Herpes Completed NCT00486200 Phase 2
37 Randomised Controlled Trial Assessing the Impact of Genital Herpes Suppressive Therapy on HIV Shedding Completed NCT00158509 Phase 2
38 Biological Efficacy Study of HerpV Vaccine With QS-21 to Treat Subjects With Recurrent Genital Herpes Completed NCT01687595 Phase 2
39 Safety and Efficacy Study for a New Antiviral Drug to Treat Genital Herpes Type 2 Completed NCT01047540 Phase 2
40 Safety and Efficacy Trial of DNA Vaccines to Treat Genital Herpes in Adults Completed NCT02030301 Phase 1, Phase 2
41 Dose Ranging Safety and Efficacy of Therapeutic HSV-2 Vaccine Completed NCT02114060 Phase 2
42 Rollover Trial for Placebo Subjects Previously Enrolled Into GEN-003-002 Study Completed NCT02300142 Phase 2
43 Safety and Immunogenicity Study of Therapeutic HSV-2 Vaccine Completed NCT01667341 Phase 1, Phase 2
44 Anti-Herpetic Treatment of Genital Ulcer : Effect on HIV & Herpes Shedding (ANRS 1212) Completed NCT00158483 Phase 2
45 Retention and Duration of Activity of SPL7013 (VivaGel®) After Vaginal Dosing. Completed NCT00740584 Phase 1, Phase 2
46 Acyclovir to Treat Patients Co-infected With HIV and Herpes Viruses in Uganda Completed NCT00405821 Phase 2
47 HSV-2 Suppression to Reduce Maternal HIV-1 RNA Levels During Pregnancy and Breastfeeding Completed NCT00530777 Phase 2
48 Safety, Acceptability and Preliminary Effectiveness of PC-515 for Vaginal Use as a Possible Microbicide Completed NCT00213031 Phase 2
49 Evaluation of the Impact of Adjuvants Accompanying Peptide Immunization in High-Risk Melanoma Completed NCT00273910 Phase 2
50 BufferGel and PRO 2000/5: Vaginal Gels to Prevent HIV Infection in Women Completed NCT00074425 Phase 2

Search NIH Clinical Center for Genital Herpes

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: herpes genitalis

Genetic Tests for Genital Herpes

Anatomical Context for Genital Herpes

MalaCards organs/tissues related to Genital Herpes:

39
Testes, T Cells, Skin, B Cells, Nk Cells, Myeloid, Cervix

The Foundational Model of Anatomy Ontology organs/tissues related to Genital Herpes:

18
Genital System, Rectum

Publications for Genital Herpes

Articles related to Genital Herpes:

(show top 50) (show all 576)
id Title Authors Year
1
A Comparative Analysis of Polymerase Chain Reaction and Direct Fluorescent Antibody Test for Diagnosis of Genital Herpes. ( 28042218 )
2017
2
Collaboration with a midwife in the care of a pregnant patient with recurrent genital herpes simplex virus. ( 27412208 )
2016
3
Interventions for men and women with their first episode of genital herpes. ( 27575957 )
2016
4
Genital Herpes: What You Should Know. ( 27281843 )
2016
5
Heterogeneous polymer composite nanoparticles loaded in situ gel for controlled release intra-vaginal therapy of genital herpes. ( 27351137 )
2016
6
Serologic Screening for Genital Herpes Infection: US Preventive Services Task Force Recommendation Statement. ( 27997659 )
2016
7
First HSV-1 non primary genital herpes in two patients. ( 27018573 )
2016
8
Medroxyprogesterone acetate and levonorgestrel increase genital mucosal permeability and enhance susceptibility to genital herpes simplex virus type 2 infection. ( 27007679 )
2016
9
JAMA patient page: Screening for Genital Herpes. ( 27997655 )
2016
10
Intravaginal Zinc Oxide Tetrapod Nanoparticles as Novel Immunoprotective Agents against Genital Herpes. ( 27183601 )
2016
11
Protection from genital herpes disease, seroconversion and latent infection in a non-lethal murine genital infection model by immunization with an HSV-2 replication-defective mutant virus. ( 26609935 )
2016
12
Metastastic vulvar squamous cell carcinoma mimicking genital herpes. ( 27752532 )
2016
13
Optimal management of genital herpes: current perspectives. ( 27358569 )
2016
14
Attitudes and Willingness to Assume Risk of Experimental Therapy to Eradicate Genital Herpes Simplex Virus Infection. ( 27513383 )
2016
15
Serologic Screening for Genital Herpes: An Updated Evidence Report and Systematic Review for the US Preventive Services Task Force. ( 27997660 )
2016
16
Effects of a traditional Chinese medicine, Longdanxiegan formula granule, on Toll-like receptor pathway in female guinea pigs with recurrent genital herpes. ( 27125405 )
2016
17
Clinical study of Gene-Eden-VIR/Novirin in genital herpes: suppressive treatment safely decreases the duration of outbreaks in both severe and mild cases. ( 27766602 )
2016
18
Screening for Genital Herpes: What Is Not to Be Done. ( 27997634 )
2016
19
Herpes simplex virus: 'to disclose or not to disclose.' An exploration of the multi-disciplinary team's role in advising patients about disclosure when diagnosed with genital herpes simplex virus. ( 27582307 )
2016
20
Nasal Immunization Confers High Avidity Neutralizing Antibody Response and Immunity to Primary and Recurrent Genital Herpes in Guinea Pigs. ( 28082979 )
2016
21
Evolution of rational vaccine designs for genital herpes immunotherapy. ( 26896782 )
2016
22
Genital herpes. ( 27109044 )
2016
23
Clinical study in genital herpes: natural Gene-Eden-VIR/Novirin versus acyclovir, valacyclovir, and famciclovir. ( 27621592 )
2016
24
Role of type-specific herpes simplex virus-1 and 2 serology as a diagnostic modality in patients with clinically suspected genital herpes: A comparative study in Indian population from a tertiary care hospital. ( 27510668 )
2016
25
OASL1 deficiency promotes antiviral protection against genital herpes simplex virus type 2 infection by enhancing type I interferon production. ( 26750802 )
2016
26
Current Concepts for Genital Herpes Simplex Virus Infection: Diagnostics and Pathogenesis of Genital Tract Shedding. ( 26561565 )
2016
27
Genital Herpes: A Review. ( 27281837 )
2016
28
Integrative pharmacokinetic-pharmacodynamic modeling and simulation of amenamevir (ASP2151) for treatment of recurrent genital herpes. ( 27461507 )
2016
29
A Recommendation Against Serologic Screening for Genital Herpes Infection-What Now? ( 27997636 )
2016
30
Genital Herpes. ( 27959656 )
2016
31
In Situ Detection of Regulatory T Cells in Human Genital Herpes Simplex Virus Type 2 (HSV-2) Reactivation and Their Influence on Spontaneous HSV-2 Reactivation. ( 27117511 )
2016
32
CLINICAL PRACTICE. Genital Herpes. ( 27532832 )
2016
33
Genital Herpes. ( 27959657 )
2016
34
False-negative type-specific glycoprotein G antibody responses in STI clinic patients with recurrent HSV-1 or HSV-2 DNA positive genital herpes, The Netherlands. ( 26755775 )
2016
35
Unfortunate synergy between HIV and genital herpes. ( 26884529 )
2016
36
A Dual-Modality Herpes Simplex Virus 2 Vaccine for Preventing Genital Herpes by Using Glycoprotein C and D Subunit Antigens To Induce Potent Antibody Responses and Adenovirus Vectors Containing Capsid and Tegument Proteins as T Cell Immunogens. ( 26041292 )
2015
37
Non-healing genital herpes mimicking donovanosis in an immunocompetent man. ( 25614521 )
2015
38
Associations between individual and relationship characteristics and genital herpes disclosure. ( 25814164 )
2015
39
Clinical Inquiry: How well do antivirals shorten genital herpes pain duration? ( 25789347 )
2015
40
Oral and Vaginal Tenofovir for Genital Herpes Simplex Virus Type 2 Shedding in Immunocompetent Women: A Double-Blind, Randomized, Cross-over Trial. ( 26044291 )
2015
41
Interferon Lambda 4 Genotype Is Not Associated with Recurrence of Oral or Genital Herpes. ( 26431156 )
2015
42
Intravenous Foscarnet With Topical Cidofovir for Chronic Refractory Genital Herpes in a Patient With AIDS. ( 26788527 )
2015
43
Novel rat models to study primary genital herpes simplex virus-2 infection. ( 25701211 )
2015
44
Molecular diagnostics and newborns at risk for genital herpes simplex virus. ( 25996200 )
2015
45
Erratum to: Diagnosis of genital herpes simplex virus infection in the clinical laboratory. ( 26463442 )
2015
46
Genital herpes: oral antiviral treatments. ( 25853497 )
2015
47
Coping strategies and behavioural changes following a genital herpes diagnosis among an urban sample of underserved Midwestern women. ( 25792549 )
2015
48
Chitosan and Kappa-Carrageenan Vaginal Acyclovir Formulations for Prevention of Genital Herpes. In Vitro and Ex Vivo Evaluation. ( 26393621 )
2015
49
Efficacy of N-methanocarbathymidine against genital herpes simplex virus type 2 shedding and infection in guinea pigs. ( 26149263 )
2015
50
Genital Herpes Simplex Virus Type 2 Shedding Among Adults With and Without HIV Infection in Uganda. ( 26486633 )
2015

Variations for Genital Herpes

Expression for Genital Herpes

Search GEO for disease gene expression data for Genital Herpes.

Pathways for Genital Herpes

Pathways related to Genital Herpes according to GeneCards Suite gene sharing:

(show all 22)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.53 CCL5 IL18 IL4 TLR2
2
Show member pathways
12.3 IL10 IL18 IL4 TBX21 TLR2
3 12.22 CCL5 IL10 IL4 TBX21 TLR2
4
Show member pathways
12.11 APOE CCL5 IL4
5
Show member pathways
12.03 IL10 IL4 TLR2
6 12 IL10 IL18 TLR2
7
Show member pathways
11.91 IL10 IL18 IL4
8 11.74 IL10 IL18 IL4
9
Show member pathways
11.72 IL18 IL4 TBX21
10 11.61 CCL5 IL18 TLR2
11
Show member pathways
11.59 IL10 IL18 TBX21 TLR2
12 11.48 IL10 IL4 TLR2
13 11.36 IL10 IL18 IL4 TBX21
14 11.14 IL10 IL18
15 11.09 IL18 IL4 TBX21
16 11.07 IL10 IL4
17 11.02 IL18 TBX21
18 10.97 IL10 IL4
19 10.96 CCL5 IL10 IL18 IL4
20 10.95 IL18 TLR2
21 10.95 CCL5 IL10 IL18 IL4
22 10.61 ACKR1 IL10 IL18 TLR2

GO Terms for Genital Herpes

Cellular components related to Genital Herpes according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.1 APOE CCL5 IFNL4 IL10 IL18 IL4

Biological processes related to Genital Herpes according to GeneCards Suite gene sharing:

(show all 19)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.96 IL10 IL18 IL4 T TLR2
2 immune response GO:0006955 9.77 CCL5 IL10 IL18 IL4 TLR2
3 negative regulation of endothelial cell apoptotic process GO:2000352 9.58 IL10 IL4
4 positive regulation of activated T cell proliferation GO:0042104 9.58 IL18 IL4
5 triglyceride homeostasis GO:0070328 9.57 APOE IL18
6 positive regulation of interleukin-10 production GO:0032733 9.55 IL4 TLR2
7 inflammatory response GO:0006954 9.55 ACKR1 CCL5 IL10 IL18 TLR2
8 positive regulation of NF-kappaB import into nucleus GO:0042346 9.54 IL18 TLR2
9 defense response to protozoan GO:0042832 9.52 IL10 IL4
10 microglial cell activation GO:0001774 9.51 IL4 TLR2
11 negative regulation of nitric oxide biosynthetic process GO:0045019 9.49 IL10 IL4
12 response to molecule of bacterial origin GO:0002237 9.48 IL10 TLR2
13 positive regulation of isotype switching to IgG isotypes GO:0048304 9.46 IL4 TBX21
14 regulation of T cell activation GO:0050863 9.43 CCL5 IFNL4
15 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.43 CCL5 IL18 IL4
16 positive regulation of MHC class II biosynthetic process GO:0045348 9.4 IL10 IL4
17 regulation of isotype switching GO:0045191 9.32 IL10 IL4
18 lipopolysaccharide-mediated signaling pathway GO:0031663 9.13 CCL5 IL18 TLR2
19 type 2 immune response GO:0042092 8.8 IL10 IL18 IL4

Molecular functions related to Genital Herpes according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CCL5 IFNL4 IL10 IL18 IL4

Sources for Genital Herpes

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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