MCID: GNT003
MIFTS: 70

Genital Herpes malady

Infectious diseases, Reproductive diseases categories
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Summaries for Genital Herpes

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MedlinePlus:33 Genital herpes is a sexually transmitted disease (std) caused by a herpes simplex virus (hsv). it can cause sores on your genital or rectal area, buttocks, and thighs. you can get it from having sex, even oral sex. the virus can spread even when sores are not present. mothers can also infect their babies during childbirth. symptoms of herpes are called outbreaks. you usually get sores near the area where the virus has entered the body. they turn into blisters, become itchy and painful, and then heal. sometimes people do not know they have herpes because they have no symptoms or very mild symptoms. the virus can be more serious in newborn babies or in people with weak immune systems. most people have outbreaks several times a year. over time, you get them less often and the symptoms become milder. the virus stays in your body for life. medicines do not cure genital herpes, but they can help your body fight the virus. this can help lessen symptoms, decrease outbreaks, and lower the risk of passing the virus to others. correct usage of latex condoms can reduce, but not eliminate, the risk of catching or spreading herpes. nih: national institute of allergy and infectious diseases

MalaCards based summary: Genital Herpes, also known as herpes genitalis, is related to herpes simplex and keratitis, and has symptoms including An important gene associated with Genital Herpes is DARC (Duffy blood group, atypical chemokine receptor), and among its related pathways are Folate Metabolism and Lymphocyte Signaling. The drugs interferon alfa-2b and acyclovir and the compounds hbd2 and amphotericin b have been mentioned in the context of this disorder. Affiliated tissues include genital system, rectum and testes, and related mouse phenotypes are renal/urinary system and digestive/alimentary.

Disease Ontology:8 A herpes simplex that results in infection located in genital system, or located in rectum, has material basis in human herpesvirus 1 or has material basis in human herpesvirus 2, which is transmitted by sexual contact. the infection has symptom sores, has symptom fever, and has symptom swollen glands.

CDC:3 Genital herpes is a common STD, and most people with genital herpes infection do not know they have it.

Wikipedia:65 Herpes genitalis (or genital herpes) is a genital infection caused by the herpes simplex virus. A 1998... more...

Aliases & Classifications for Genital Herpes

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Genital Herpes, Aliases & Descriptions:

Name: Genital Herpes 8 10 44 33 62
Herpes Genitalis 8 62
Herpes Genitalia 8 62
Venereal Herpes 8 62
 
Herpes Simplex, Genital 62
Genital Herpes Simplex 8
Virus-Genital Herpes 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Reproductive diseases


External Ids:

Disease Ontology8 DOID:8704
ICD9CM27 054.1, 054.10
MeSH34 D006558
NCIt39 C14364

Related Diseases for Genital Herpes

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Diseases related to Genital Herpes via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 94)
idRelated DiseaseScoreTop Affiliating Genes
1herpes simplex31.0DARC, HLA-B, TLR2, CCL5, IFNA1, GGH
2keratitis30.5DARC, TLR2
3leukemia29.4HLA-B, TLR2, CCL3, IFNA1, IL4, GGH
4encephalitis29.3DARC, HLA-B, TLR2, CCL3, CCL5, IFNA1
5blindness10.6
6folliculitis10.6DEFB4A
7sinusitis10.6DEFB4A
8meningoencephalitis10.5CCL5
9rhinotracheitis10.5PI3, DARC
10lichen planus10.4DEFB4A
11extrinsic allergic alveolitis10.3CCL3, PI3
12vaginitis10.3
13aspergillosis10.3TLR2, CCL3
14leprosy10.3TLR2
15systemic mastocytosis10.3CCL3, CCL5
16lepromatous leprosy10.3TLR2, IL4
17hiv-110.3
18chancroid10.3
19herpes zoster10.3
20neonatal herpes10.3
21alcoholic hepatitis10.3CCL3, CCL5
22bacterial meningitis10.3CCL3, TLR2
23dengue disease10.3CCL3, CCL5
24vernal keratoconjunctivitis10.3CCL5, IL4
25lyme disease10.3TLR2, CCL3
26human immunodeficiency virus infectious disease10.2ATAD2, CCL3
27pulmonary eosinophilia10.2IL4, CCL3
28idiopathic myopathy10.2HLA-B, CCL5
29periodontal disease10.2DEFB4A, TLR2, CCL3
30atopic dermatitis10.2DEFB4A, TLR2, IL4
31sarcoidosis10.2DEFB4A, CCL3, CCL5
32chronic lymphocytic leukemia10.2
33gonorrhea10.2
34lymphogranuloma venereum10.2
35syphilis10.2
36urticaria10.2
37interstitial lung disease10.2CCL5, CCL3
38atopy10.2IL4, CCL5, TLR2
39periapical granuloma10.1CCL3, CCL5, IL4
40bronchiolitis10.1CCL5, CCL3
41allergic rhinitis10.1TLR2, CCL5, IL4
42pulmonary tuberculosis10.1TLR2, CCL3, IL4
43sepsis10.1CCL3, TLR2, PI3, DEFB4A
44pulmonary sarcoidosis10.1CCL3, CCL5
45skin disease10.1IL4, TLR2, PI3, DEFB4A
46chronic obstructive pulmonary disease10.1CCL5, CCL3, TLR2, PI3
47relapsing-remitting multiple sclerosis10.1CCL5, IFNA1
48gastritis10.1DEFB4A, TLR2, CCL3, CCL5
49colitis10.1DEFB4A, TLR2, T, IL4
50osteoarthritis10.1DEFB4A, TLR2, CCL3, CCL5

Graphical network of the top 20 diseases related to Genital Herpes:



Diseases related to genital herpes

Symptoms for Genital Herpes

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Drugs & Therapeutics for Genital Herpes

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Drug clinical trials:

Search ClinicalTrials for Genital Herpes

Search NIH Clinical Center for Genital Herpes

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Genital Herpes

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Anatomical Context for Genital Herpes

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MalaCards organs/tissues related to Genital Herpes:

32
Testes, T cells, Skin, Nk cells, B cells, Cervix, Myeloid

FMA organs/tissues related to Genital Herpes:

14
Genital system, Rectum

Animal Models for Genital Herpes or affiliated genes

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MGI Mouse Phenotypes related to Genital Herpes:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.8IL4, NXF1, APOE, T, TLR2
2MP:00053818.4TBX21, TLR2, T, APOE, CCL3, IL4
3MP:00053877.7DARC, HLA-B, TLR2, APOE, CCL3, CCL5
4MP:00053977.6HLA-B, TLR2, APOE, CCL3, CCL5, IL4
5MP:00036317.3HLA-B, TLR2, T, APOE, NXF1, CCL3

Publications for Genital Herpes

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Articles related to Genital Herpes:

(show top 50)    (show all 510)
idTitleAuthorsYear
1
Chancroid, lymphogranuloma venereum, granuloma inguinale, genital herpes simplex infection, and molluscum contagiosum. (24559566)
2014
2
Status of prophylactic and therapeutic genital herpes vaccines. (24631871)
2014
3
Vaxfectin-adjuvanted plasmid DNA vaccine improves protection and immunogenicity in a murine model of genital herpes infection. (22398318)
2012
4
Looking for an asymptomatic infection: usefulness of screening for Chlamydia trachomatis and genital herpes. (23007249)
2012
5
Using centralized laboratory data to monitor trends in herpes simplex virus type 1 and 2 infection in British Columbia and the changing etiology of genital herpes. (21714324)
2011
6
Clarification in law is sought after man is jailed for infecting partner with genital herpes. (21859791)
2011
7
Effect of ASP2151, a herpesvirus helicase-primase inhibitor, in a guinea pig model of genital herpes. (21869749)
2011
8
Suppressive valacyclovir therapy to reduce genital herpes transmission: good public health policy? (19753286)
2009
9
New concepts in understanding genital herpes. (19857385)
2009
10
Valacyclovir to reduce transmission of genital herpes simplex virus infection. (19239344)
2009
11
Comparison of nested-polymerase chain reaction and virus culture for the diagnosis of genital herpes simplex virus infection. (18581019)
2008
12
Is suspicion of genital herpes infection associated with avoiding sex? A clinic-based study. (18771644)
2008
13
Knowledge about genital herpes amongst first time attenders at a department of genitourinary medicine. (18422207)
2008
14
Famciclovir treatment options for patients with frequent outbreaks of recurrent genital herpes: the RELIEF trial. (18621575)
2008
15
Managing genital herpes infections in pregnancy. (17375803)
2007
16
Susceptibility of CCR5-deficient mice to genital herpes simplex virus type 2 is linked to NK cell mobilization. (17267483)
2007
17
Genital herpes and its management. (17510153)
2007
18
Suppressive therapy with valacyclovir in early genital herpes: a pilot study of clinical efficacy and herpes-related quality of life. (17065847)
2007
19
Genital herpes in Africa: time to rethink treatment. (18156037)
2007
20
Single-day therapy: an expert opinion on a recent development for the episodic treatment of recurrent genital herpes. (16957911)
2007
21
Adolescents anticipated experience of screening for genital herpes. (16895656)
2006
22
National survey of diagnostic services for genital herpes. (16061538)
2005
23
The cotton rat provides a novel model to study genital herpes infection and to evaluate preventive strategies. (16282463)
2005
24
Genital herpes. (16620476)
2005
25
Counseling the patient who has genital herpes or genital human papillomavirus infection. (15963883)
2005
26
Neurokinin 1 receptor signaling affects the local innate immune defense against genital herpes virus infection. (16272337)
2005
27
Genital herpes: common but misunderstood. Don't assume that genital herpes isn't your concern. (16435436)
2005
28
Epidemiology of genital herpes simplex virus infections in a community-based sample in France: results of the HERPIMAX study. (16041253)
2005
29
Genital herpes. (15652098)
2004
30
Expert commentary: genital herpes transmission. (15955269)
2004
31
The theoretical basis of stigma as applied to genital herpes. (15115630)
2004
32
Changing epidemiology of genital herpes simplex virus infection in Melbourne, Australia, between 1980 and 2003. (15295125)
2004
33
Oral famciclovir for the suppression of recurrent genital herpes: the combined data from two randomized controlled trials. (15931690)
2003
34
Study of knowledge of genital herpes infection and attitudes to testing for genital herpes among antenatal clinic attendees. (14717310)
2003
35
Predominance of herpes simplex virus type 1 from patients with genital herpes in Nova Scotia. (18159431)
2003
36
Progress in meeting today's demands in genital herpes: an overview of current management. (12353187)
2002
37
Genital herpes. (11991914)
2002
38
Aborted genital herpes simplex virus lesions: findings from a randomised controlled trial with valaciclovir. (12473805)
2002
39
Psychosocial outcomes in individuals living with genital herpes. (12353728)
2002
40
Imiquimod and genital herpes. (11939822)
2002
41
The ratio of cytokine levels in genital herpes during various phases of infection. (11687847)
2001
42
Patients' perspectives on the burden of recurrent genital herpes. (11564330)
2001
43
Seroprevalence of herpes simplex virus type 1 and type 2 in selected German populations-relevance for the incidence of genital herpes. (10797375)
2000
44
Improving the care of patients with genital herpes. (10977846)
2000
45
Cooperative agreements for strategies to prevent genital herpes infections: building a national prevention program, notice of availability of funds. Centers for Disease Control and Prevention. (10558529)
1999
46
Medication tames genital herpes. (14612772)
1999
47
Quality of life and use of health care among people with genital herpes in France. (10494718)
1999
48
Valaciclovir: new indications. In genital herpes: simpler administration. (10557565)
1999
49
Undocumented history of maternal genital herpes followed by neonatal herpes meningitis. (8064427)
1994
50
Psychological investigation of genital herpes recurrence: prospective assessment and cognitive-behavioral intervention for a chronic physical disorder. (3383831)
1988

Variations for Genital Herpes

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Expression for genes affiliated with Genital Herpes

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Expression patterns in normal tissues for genes affiliated with Genital Herpes

Search GEO for disease gene expression data for Genital Herpes.

Pathways for genes affiliated with Genital Herpes

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Pathways related to Genital Herpes according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Vitamin B12 Metabolism37
9.9CCL5, APOE
29.7CCL5, IL4, TBX21
3
Show member pathways
9.7TBX21, IL4, TLR2
4
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.7IL4, TLR2, DEFB4A
5
Show member pathways
9.2CCL5, CCL3, DARC
6
Show member pathways
Immune response IL 12 induced IFN gamma production60
9.1CCL3, IL4, TBX21
79.1CCL5, CCL3, TLR2
8
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.6TLR2, CCL3, CCL5, IFNA1
9
Show member pathways
8.2IL4, IFNA1, CCL5, NXF1, TLR2, HLA-B

Compounds for genes affiliated with Genital Herpes

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Compounds related to Genital Herpes according to GeneCards/GeneDecks:

(show top 50)    (show all 85)
idCompoundScoreTop Affiliating Genes
1hbd24410.2DEFB4A, PI3, TLR2
2amphotericin b4410.0IL4, CCL5, TLR2
3betaseron449.9IL4, IFNA1
4loxoribine44 2810.9IFNA1, TLR2
5glatiramer acetate44 1110.8CCL5, IFNA1, IL4
6ursodeoxycholic acid44 24 1111.6IFNA1, APOE, HLA-B
7mip 1alpha449.5IL4, CCL5, CCL3
8anaphylatoxin449.4CCL3, CCL5, IL4
9gm-csf44 2810.4IL4, CCL5, CCL3
10resiquimod44 6110.4IFNA1, TLR2
11methacholine44 50 1111.4CCL3, CCL5, IL4
12ccl444 2810.3TLR2, CCL3, CCL5
13tarc449.3IL4, CCL5, CCL3
14chloroquine44 2 50 28 1113.3IL4, IFNA1, APOE
15peptidoglycan44 2810.3CCL5, CCL3, TLR2, DEFB4A
16sp 60012544 6110.2DEFB4A, TLR2, CCL3, CCL5
17lipoteichoic acid449.2DEFB4A, HLA-B, TLR2, CCL3
18il 10449.2IL4, CCL5, CCL3, TLR2
19ritonavir44 50 1111.2APOE, CCL3, CCL5, IL4
20heparan sulfate44 2410.2TLR2, CCL3, CCL5, GGH
21ionomycin449.1IL4, CCL5, CCL3, TLR2
22pdtc449.1IL4, CCL5, CCL3
23ccl344 2810.0TLR2, CCL3, CCL5, IFNA1
24neopterin449.0IL4, IFNA1, CCL3
25endotoxin449.0DEFB4A, HLA-B, TLR2, CCL3, CCL5
26ribonucleic acid448.9HLA-B, TLR2, CCL3, CCL5
27simvastatin44 50 61 28 24 1113.9TLR2, APOE, CCL3, CCL5, IL4
28ribavirin44 50 1110.9HLA-B, CCL3, IFNA1, IL4
29bleomycin44 119.9IL4, IFNA1, CCL3, APOE
30indomethacin44 28 61 1111.8APOE, CCL3, CCL5, IL4
31lipid448.8DARC, DEFB4A, PI3, HLA-B, TLR2, APOE
32sb 20358044 619.8DEFB4A, PI3, TLR2, CCL3, CCL5, IL4
33histamine44 28 2410.8DEFB4A, PI3, TLR2, CCL3, CCL5, IL4
34pge2448.7HLA-B, TLR2, CCL3, CCL5, IL4
35poly(i-c)448.7TLR2, CCL3, CCL5, IFNA1, IL4
36polyinosinic-polycytidylic acid448.6HLA-B, TLR2, CCL3, IFNA1, IL4
37actinomycin d448.6TLR2, APOE, CCL3, IFNA1, IL4
38h2o2448.5HLA-B, TLR2, APOE, CCL3, CCL5
39tyrosine448.5DARC, DEFB4A, PI3, HLA-B, TLR2, CCL5
40tacrolimus44 50 1110.4HLA-B, TLR2, CCL3, CCL5, IFNA1, IL4
41cholesterol44 28 24 1111.3HLA-B, TLR2, APOE, CCL3, CCL5
42cycloheximide448.3TLR2, APOE, CCL3, CCL5, IFNA1, IL4
43vegf448.3TLR2, APOE, CCL3, CCL5, IFNA1, IL4
44alanine448.2DARC, TLR2, APOE, CCL3, CCL5, IFNA1
45retinoic acid44 249.2DEFB4A, PI3, HLA-B, TLR2, CCL3, CCL5
46cysteine448.0DEFB4A, PI3, TLR2, APOE, CCL3, CCL5
47rantes448.0IL4, DARC, DEFB4A, HLA-B, TLR2, CCL3
48dexamethasone44 50 28 1110.9DEFB4A, PI3, HLA-B, TLR2, CCL3, CCL5
49cyclosporin a44 28 619.9PI3, HLA-B, TLR2, APOE, CCL3, CCL5
50serine447.5PI3, HLA-B, TLR2, APOE, NXF1, CCL3

GO Terms for genes affiliated with Genital Herpes

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Cellular components related to Genital Herpes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5GGH, IL4, CCL5, CCL3, APOE

Biological processes related to Genital Herpes according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of isotype switching to IgG isotypesGO:04830410.3IL4, TBX21
2positive regulation of interleukin-10 productionGO:03273310.0TLR2, IL4
3response to insulinGO:03286810.0GGH, APOE, TLR2
4response to ethanolGO:0454719.9GGH, IL4, APOE
5chemokine-mediated signaling pathwayGO:0700989.7CCL5, DARC
6positive regulation of natural killer cell chemotaxisGO:20005039.7CCL5, CCL3
7eosinophil chemotaxisGO:0482459.7CCL3, CCL5
8negative regulation by host of viral transcriptionGO:0439229.6CCL3, CCL5
9macrophage chemotaxisGO:0482469.6CCL5, CCL3
10immune responseGO:0069559.6IL4, TLR2, HLA-B, DEFB4A
11monocyte chemotaxisGO:0025489.6CCL5, CCL3
12negative regulation of osteoclast differentiationGO:0456719.5IL4, CCL3
13cellular response to interferon-gammaGO:0713469.5CCL5, CCL3
14lipopolysaccharide-mediated signaling pathwayGO:0316639.4CCL5, CCL3, TLR2
15response to toxic substanceGO:0096369.4CCL5, CCL3, TLR2
16cellular response to interleukin-1GO:0713479.4APOE, CCL3, CCL5
17positive regulation of calcium ion transportGO:0519289.4CCL3, CCL5
18protein kinase B signalingGO:0434919.4CCL5, CCL3
19cellular calcium ion homeostasisGO:0068749.4CCL5, CCL3, APOE
20positive chemotaxisGO:0509189.3CCL5, CCL3
21chemotaxisGO:0069359.2IL4, CCL5, CCL3, DEFB4A
22inflammatory responseGO:0069549.2DARC, TLR2, CCL3, CCL5

Molecular functions related to Genital Herpes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phospholipase activator activityGO:0160049.4CCL5, CCL3
2chemoattractant activityGO:0420569.4CCL5, CCL3
3CCR1 chemokine receptor bindingGO:0317269.3CCL5, CCL3
4CCR5 chemokine receptor bindingGO:0317309.1CCL5, CCL3

Products for genes affiliated with Genital Herpes

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Sources for Genital Herpes

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet