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MCID: GGR001
MIFTS: 46

Geographic Tongue malady

Categories: Rare diseases, Gastrointestinal diseases, Oral diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Geographic Tongue

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Aliases & Descriptions for Geographic Tongue:

Name: Geographic Tongue 12 50 14
Glossitis, Benign Migratory 42 69
Benign Migratory Glossitis 12 50
Glossitis Areata Exfoliativa 12
Erythema Chronicum Migrans 69
Ectopic Geographic Tongue 50
Pityriasis Linguae 12
Erythema Migrans 50

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Gastrointestinal diseases Oral diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:1455
ICD10 33 K14.1
ICD9CM 35 529.1
MeSH 42 D005929
NCIt 47 C84588
UMLS 69 C0017677
Sources

Summaries for Geographic Tongue

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NIH Rare Diseases : 50 geographic tongue is a condition that causes chronic and recurrent lesions on the tongue that resemble psoriasis of the skin. it is characterized by pink to red, slightly depressed lesions with irregular, elevated, white or yellow borders. the lesions may also occur in the mucosa of the mouth and labia; this condition is called "areata migrans" because these lesions typically disappear from one area and show up in another. the tongue is normally covered with tiny, pinkish-white bumps (papillae), which are actually short, fine, hair-like projections. with geographic tongue, patches on the surface of the tongue are missing papillae and appear as smooth, red "islands," often with slightly raised borders. these patches (lesions) give the tongue a map-like, or geographic, appearance. in most cases there are no symptoms but sometimes it is painful when inflamed. the cause of this condition is unknown. many researchers think it is linked with psoriasis, but more research is needed to better understand the connection. also, hereditary and environmental factors may be involved. the condition is benign and localized, generally requiring no treatment except reassurance. if painful, it may be treated with steroid gels or antihistamine mouth rinses.  last updated: 4/14/2016

MalaCards based summary : Geographic Tongue, also known as glossitis, benign migratory, is related to lyme disease and fissured tongue, and has symptoms including exanthema and glossalgia. An important gene associated with Geographic Tongue is IL36RN (Interleukin 36 Receptor Antagonist), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and Cytokine Signaling in Immune system. The drugs Doxycycline and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include tongue and skin, and related phenotypes are Increased shRNA abundance (Z-score > 2) and liver/biliary system

Disease Ontology : 12 An atrophic glossitis that is characterized as an inflammatory condition of the mucous membrane of the tongue, usually on the dorsal surface.

Wikipedia : 71 Geographic tongue, also known by several other terms,[note 1] is an inflammatory condition of the mucous... more...

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Related Diseases for Geographic Tongue

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Diseases related to Geographic Tongue via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
id Related Disease Score Top Affiliating Genes
1 lyme disease 11.5
2 fissured tongue 11.4
3 solid pseudopapillary carcinoma of pancreas 10.3 HLA-A HLA-B
4 apple allergy 10.3 HLA-DQB1 HLA-DRB1
5 hodgkin's paragranuloma 10.3 HLA-DQB1 HLA-DQB2
6 hemoglobin d disease 10.3 HLA-DQB1 HLA-DRB1
7 myopathy, congenital nonprogressive, with moebius sequence and robin sequence 10.3 HLA-A HLA-B
8 ragweed sensitivity 10.2 HLA-DQB1 HLA-DQB2 HLA-DRB1
9 sacral nerve root cysts 10.2 HLA-A HLA-B HLA-DRB1
10 bilateral parasagittal parieto-occipital polymicrogyria 10.2 HLA-DQB1 HLA-DRB1
11 hernia of ovary and fallopian tube 10.2 HLA-A HLA-B HLA-DRB1
12 immune deficiency, familial variable 10.2 HLA-B HLA-DQB1 HLA-DRB1
13 nystagmus, congenital motor, autosomal recessive 10.2 HLA-A HLA-B HLA-DRB1
14 aseptic meningitis 10.2 HLA-A HLA-B HLA-DRB1
15 cervical adenoid basal carcinoma 10.2 HLA-B HLA-DQB1 HLA-DRB1
16 epididymo-orchitis 10.2 HLA-A HLA-B HLA-C
17 acanthoma 10.2 HLA-A HLA-B HLA-DRB1
18 lin-gettig syndrome 10.2 HLA-DQB1 HLA-DRB1
19 colorectal cancer, hereditary nonpolyposis, type 6 10.2 HLA-A HLA-B HLA-C
20 b-cell lymphomas 10.2 HLA-A HLA-DQB1 HLA-DRB1
21 cryptococcosis 10.2 HLA-B HLA-DQB1 HLA-DRB1
22 pyridoxine-responsive sideroblastic anemia 10.2 CD79A TGM2
23 rete testis adenocarcinoma 10.2 AKTIP HLA-A HLA-DQB1 IL36RN
24 patau syndrome 10.2 HLA-A HLA-DRB1 TNFRSF10B
25 orbital osteomyelitis 10.2 HLA-A HLA-B HLA-C
26 clostridium difficile colitis 10.2 CD79A HLA-DQB1 HLA-DRB1
27 squamous cell papilloma of skin 10.2 AKTIP CD79A HLA-A
28 pemphigus vulgaris, familial 10.2 HLA-A HLA-B HLA-DRB1
29 acute cholangitis 10.2 HLA-B HLA-C HLA-DRB1
30 mirizzi syndrome 10.2 HLA-B HLA-DRB1
31 acrodermatitis 10.2
32 lymphangiectasia, intestinal 10.2 CD79A HLA-DQB1 HLA-DRB1
33 choreatic disease 10.2 CD79A HLA-DQB1 HLA-DRB1
34 pseudohypoparathyroidism 10.2 CD79A HLA-C HLA-DRB1
35 cutaneous solitary mastocytoma 10.1 CD79A TGM2
36 parasitic helminthiasis infectious disease 10.1 HLA-A HLA-B HLA-DQB1 HLA-DRB1
37 neonatal antiphospholipid syndrome 10.1 HLA-DQB1 HLA-DRB1 VEGFA
38 good syndrome 10.1 CD79A HLA-DQB1 TGM2
39 amyotrophic lateral sclerosis type 10 10.1 CD79A TGM2
40 midline interhemispheric variant of holoprosencephaly 10.1 HLA-DQB1 HLA-DRB1
41 acrodermatitis chronica atrophicans 10.1
42 monocytic leukemia 10.1 CD79A HLA-DQB1 HLA-DRB1
43 hepatitis 10.1 HLA-A HLA-B HLA-C HLA-DRB1
44 disease of mental health 10.1 CD79A HLA-B HLA-DRB1
45 autosomal recessive congenital methemoglobinemia 10.1 EPHX1 HLA-A HLA-B HLA-C
46 psoriasis susceptibility 1 10.1 EPHX1 HLA-A HLA-B HLA-C
47 barbiturate abuse 10.1 CD79A HLA-DQB1 TGM2
48 partial sensory epilepsy 10.1 BRD4 CD79A
49 inflammatory bowel disease 3 10.0 CD79A HLA-A HLA-DQB1 TGM2
50 learning disability 10.0 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1

Graphical network of the top 20 diseases related to Geographic Tongue:



Diseases related to Geographic Tongue
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Symptoms & Phenotypes for Geographic Tongue

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UMLS symptoms related to Geographic Tongue:


exanthema, glossalgia

GenomeRNAi Phenotypes related to Geographic Tongue according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.48 HLA-C HLA-A HLA-B
2 Increased shRNA abundance (Z-score > 2) GR00366-A-11 10.48 CD79A
3 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.48 HLA-A HLA-B HLA-C
4 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.48 EGFR HLA-C HLA-A HLA-B
5 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10.48 EGFR
6 Increased shRNA abundance (Z-score > 2) GR00366-A-124 10.48 HLA-C
7 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.48 HLA-C
8 Increased shRNA abundance (Z-score > 2) GR00366-A-156 10.48 HLA-A HLA-B HLA-C
9 Increased shRNA abundance (Z-score > 2) GR00366-A-162 10.48 HLA-C
10 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10.48 CD79A
11 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.48 HLA-A HLA-B HLA-C
12 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.48 HLA-A HLA-B HLA-C
13 Increased shRNA abundance (Z-score > 2) GR00366-A-190 10.48 EGFR
14 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.48 HLA-C
15 Increased shRNA abundance (Z-score > 2) GR00366-A-21 10.48 EGFR
16 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.48 EGFR
17 Increased shRNA abundance (Z-score > 2) GR00366-A-31 10.48 HLA-A HLA-B HLA-C
18 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.48 EGFR
19 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.48 HLA-C
20 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.48 CD79A
21 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.48 HLA-C HLA-A HLA-B
22 Increased shRNA abundance (Z-score > 2) GR00366-A-70 10.48 CD79A
23 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.48 HLA-A HLA-B HLA-C CD79A
24 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.48 EGFR
25 Increased shRNA abundance (Z-score > 2) GR00366-A-93 10.48 HLA-C

MGI Mouse Phenotypes related to Geographic Tongue:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.5 WHRN CD79A EGFR HLA-DQB1 NME1 THEM5
2 neoplasm MP:0002006 9.1 CD79A EGFR EPHX1 NME1 TGM2 VEGFA
Sources

Drugs & Therapeutics for Geographic Tongue

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Drugs for Geographic Tongue (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
2
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
3
Cefuroxime Approved Phase 4 55268-75-2 5361202 5479529
4
Penicillin V Approved, Vet_approved Phase 4 87-08-1 6869
5 Anti-Bacterial Agents Phase 4,Phase 1,Phase 2
6 Anti-Infective Agents Phase 4,Phase 1,Phase 2
7 Antimalarials Phase 4
8 Antiparasitic Agents Phase 4
9 Antiprotozoal Agents Phase 4
10 penicillins Phase 4
11 cefuroxime axetil Phase 4
12 Antibiotics, Antitubercular Phase 4,Phase 1,Phase 2
13
Ceftriaxone Approved 73384-59-5 5479530 5361919
14 Antitubercular Agents

Interventional clinical trials:

(show all 17)
id Name Status NCT ID Phase
1 Comparison of Doxycycline and Cefuroxime Axetil for Treatment of Erythema Migrans: Clinical and Microbiological Outcome Completed NCT01518192 Phase 4
2 Comparing 3 Antibiotic Regimes for Erythema Migrans in General Practice Completed NCT01368341 Phase 4
3 Xenodiagnosis After Antibiotic Treatment for Lyme Disease Recruiting NCT02446626 Phase 1, Phase 2
4 Lyme Borreliosis and Early Cutaneous Diagnostic Unknown status NCT02414789
5 Doxycycline and Ceftriaxone in Suspected Early Lyme Neuroborreliosis Unknown status NCT00942006
6 The Relationship Between Allergic Rhinitis and Geographic Tongue Unknown status NCT01454492
7 Duration of Antibiotic Treatment of Erythema Migrans Completed NCT00910715
8 Doxycycline in Therapy of Erythema Migrans Completed NCT01475708
9 Culture Media for Borrelia Burgdorferi Sensu Lato Completed NCT02145754
10 Searching for Persistence of Infection in Lyme Disease Completed NCT01143558 Early Phase 1
11 Cytokines and Chemokines in Erythema Migrans Recruiting NCT02147249
12 Antibiotic Treatment of Multiple Erythema Migrans Recruiting NCT01163994
13 Analysis of Lyme Disease Lesions Recruiting NCT00132327
14 Borrelia Species in Cutaneous Lyme Borreliosis Recruiting NCT00576082
15 A Multicenter Study to Evaluate a Borrelia Diagnostic Test in Subjects With Early Stage or Late Stage Lyme Disease Recruiting NCT02741609
16 Duration of Doxycycline Treatment in EM Patients Not yet recruiting NCT03153267
17 Investigation of Southern Tick-Associated Rash Illness (STARI) Terminated NCT00358761

Search NIH Clinical Center for Geographic Tongue

Cochrane evidence based reviews: glossitis, benign migratory

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Genetic Tests for Geographic Tongue

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Anatomical Context for Geographic Tongue

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MalaCards organs/tissues related to Geographic Tongue:

39
Tongue, Skin
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Publications for Geographic Tongue

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Articles related to Geographic Tongue:

(show all 49)
id Title Authors Year
1
Oral medicine: Factors associated with geographic tongue and fissured tongue. ( 27388082 )
2016
2
Geographic tongue. ( 27505875 )
2016
3
Mutations in IL36RN are associated with geographic tongue. ( 27900482 )
2016
4
Geographic tongue and psoriasis: clinical, histopathological, immunohistochemical and genetic correlation - a literature review. ( 27579734 )
2016
5
Geographic tongue associated with sialadenitis. ( 27726175 )
2016
6
Treatment of Symptomatic Geographic Tongue with Triamcinolone Acetonide Alone and in Combination with Retinoic Acid: A Randomized Clinical Trial. ( 27536325 )
2016
7
Paediatric Geographic Tongue: A Case Report, Review and Recent Updates. ( 27042597 )
2016
8
IMAGES IN CLINICAL MEDICINE. Geographic Tongue. ( 26886524 )
2016
9
The prevalence of celiac disease in patients with geographic tongue. ( 27131886 )
2016
10
Geographic Tongue. ( 27436616 )
2016
11
Geographic tongue and fissured tongue in 348 patients with psoriasis: correlation with disease severity. ( 25685842 )
2015
12
Factors associated with geographic tongue and fissured tongue. ( 26381370 )
2015
13
Prevalence of Geographic tongue and Related Predisposing Factors in 7-18 Year-Old Students in Kermanshah, Iran 2014. ( 26156909 )
2015
14
Psychological parameters associated with geographic tongue: a clinical observation. ( 25482552 )
2015
15
Psychological parameters associated with geographic tongue: a clinical observation. ( 25482551 )
2015
16
Geographic tongue in monozygotic twins. ( 24959517 )
2014
17
Immunologic and psychologic parameters associated with geographic tongue. ( 24842481 )
2014
18
Medical image. A benign glossal lesion. Geographic tongue. ( 24929575 )
2014
19
Case of the month. Ectopic geographic tongue (erythema migrans). ( 24937889 )
2014
20
Relation between psoriasis and geographic tongue. ( 25584342 )
2014
21
A possible relationship of human leucocyte antigens with psoriasis vulgaris and geographic tongue. ( 25176018 )
2014
22
Treatment of geographic tongue with topical tacrolimus. ( 25085945 )
2014
23
The comparison of salivary level of estrogen and progesterone in 1(st) , 2(nd) and 3(rd) trimester in pregnant women with and without geographic tongue. ( 24348617 )
2013
24
Oral and maxillofacial pathology case of the month. Erythema migrans (ectopic migratory glossitis/ectopic geographic tongue). ( 24236384 )
2013
25
Geographic tongue and tenofovir. ( 23598934 )
2013
26
Geographic tongue induced by angiogenesis inhibitors. ( 23576484 )
2013
27
Geographic Tongue and Associated Risk Factors among Iranian Dental Patients. ( 23515238 )
2013
28
Increased prevalence of geographic tongue in burning mouth complaints: a retrospective study. ( 22901641 )
2012
29
Migratory stomatitis (ectopic geographic tongue) on the floor of the mouth. ( 21763590 )
2011
30
Geographic tongue treated with topical tacrolimus. ( 21886753 )
2010
31
Images in clinical medicine. Geographic tongue. ( 19907039 )
2009
32
Allergic contact stomatitis presenting as geographical tongue with pruritus. ( 19207382 )
2009
33
Oral medicine case book 7. Migratory stomatitis and geographic tongue. ( 18689340 )
2008
34
Ectopic geographic tongue--a case report. ( 17432777 )
2007
35
Recurrent geographical tongue and fissured tongue in association with pregnancy. ( 17243991 )
2007
36
Prevalence and risk factors associated with geographic tongue among US adults. ( 16792723 )
2006
37
The prevalence and significance of fissured tongue and geographical tongue in psoriatic patients. ( 16487088 )
2006
38
Geographic tongue: clinical characteristics of 188 cases. ( 15719084 )
2005
39
Geographic tongue: literature review and case reports. ( 16161818 )
2005
40
Painful geographic tongue (benign migratory glossitis) in a child. ( 15482313 )
2004
41
Prevalence of fissured tongue, geographic tongue and median rhomboid glossitis among Israeli adults of different ethnic origins. ( 15316160 )
2004
42
Benign migratory glossitis or geographic tongue: an enigmatic oral lesion. ( 12517366 )
2002
43
Geographic tongue (migrant glossitis) and psoriasis. ( 11535977 )
2001
44
Melkersson - rosenthal syndrome with geographical tongue. ( 20944302 )
1997
45
Occurrence of fissured tongue, geographic tongue and filiform atrophy among dental patients in Saudi Arabia. ( 3867320 )
1985
46
Prevalence of geographic tongue, fissured tongue, median rhomboid glossitis, and hairy tongue among 3,611 Minnesota schoolchildren. ( 5270895 )
1970
47
Incidence of geographic tongue and median rhomboid glossitis in 3,319 Negro college students. ( 5245682 )
1968
48
SIMULATANEOUS OCCURRENCE OF GEOGRAPHIC TONGUE AND HAIRY TONGUE. ( 14315909 )
1965
49
Some observations on 1246 cases of geographic tongue: the association between geographic tongue, seborrheic dermatitis, and spasmodic bronchitis; transition of geographic tongue to fissured tongue. ( 13410386 )
1957
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Variations for Geographic Tongue

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Expression for Geographic Tongue

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Search GEO for disease gene expression data for Geographic Tongue.
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Pathways for Geographic Tongue

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Pathways related to Geographic Tongue according to GeneCards Suite gene sharing:

(show all 17)
id Super pathways Score Top Affiliating Genes
1
Class I MHC mediated antigen processing and presentation 62
Show member pathways
 13.26 CD79A EGFR HLA-A HLA-B HLA-C HLA-DQB1
2
Cytokine Signaling in Immune system 62
Show member pathways
 13.17 EGFR HLA-A HLA-B HLA-C HLA-DQB1 HLA-DQB2
3
Actin Nucleation by ARP-WASP Complex 60
Show member pathways
 12.8 EGFR HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1
4
Allograft rejection 1 37
Show member pathways
 12.65 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1 VEGFA
5
Influenza A 37
Show member pathways
 12.57 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1 TNFRSF10B
6
Immune response Role of DAP12 receptors in NK cells 21
Show member pathways
 12.34 HLA-A HLA-B HLA-C TNFRSF10B
7
Endocytosis 37
12.24 EGFR HLA-A HLA-B HLA-C
8
HTLV-I infection 37
12.17 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1
9
Epstein-Barr virus infection 37
11.96 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1
10
Interferon gamma signaling 62
Show member pathways
 11.92 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DQB2 HLA-DRB1
11
Translocation of ZAP-70 to Immunological synapse 62
Show member pathways
 11.78 HLA-DQB1 HLA-DQB2 HLA-DRB1
12
G-protein signaling N-RAS regulation pathway 21
Show member pathways
 11.77 EGFR HLA-DQB1 HLA-DQB2 HLA-DRB1
13
MHC class II antigen presentation 62
11.74 HLA-DQB1 HLA-DQB2 HLA-DRB1
14
Phagosome 37
11.74 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1
15
Rheumatoid arthritis 37
11.67 HLA-DQB1 HLA-DRB1 VEGFA
16
Cell adhesion molecules (CAMs) 37
11.18 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1
17
Antigen Presentation- Folding, assembly and peptide loading of class I MHC 62
10.9 HLA-A HLA-B HLA-C
Sources

GO Terms for Geographic Tongue

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Cellular components related to Geographic Tongue according to GeneCards Suite gene sharing:

(show all 15)
id Name GO ID Score Top Affiliating Genes
1 Golgi membrane GO:0000139 9.87 EGFR HLA-A HLA-B HLA-C HLA-DQB1 HLA-DQB2
2 endosome membrane GO:0010008 9.83 EGFR HLA-DQB1 HLA-DQB2 HLA-DRB1
3 cell surface GO:0009986 9.8 EGFR HLA-A HLA-B HLA-C HLA-DRB1 TNFRSF10B
4 trans-Golgi network membrane GO:0032588 9.72 HLA-DQB1 HLA-DQB2 HLA-DRB1
5 phagocytic vesicle membrane GO:0030670 9.71 HLA-A HLA-B HLA-C
6 early endosome membrane GO:0031901 9.71 EGFR HLA-A HLA-B HLA-C
7 endocytic vesicle membrane GO:0030666 9.69 HLA-DQB1 HLA-DQB2 HLA-DRB1
8 recycling endosome membrane GO:0055038 9.67 HLA-A HLA-B HLA-C
9 transport vesicle membrane GO:0030658 9.65 HLA-DQB1 HLA-DQB2 HLA-DRB1
10 clathrin-coated endocytic vesicle membrane GO:0030669 9.63 HLA-DQB1 HLA-DQB2 HLA-DRB1
11 MHC class II protein complex GO:0042613 9.54 HLA-DQB1 HLA-DQB2 HLA-DRB1
12 ER to Golgi transport vesicle membrane GO:0012507 9.43 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DQB2 HLA-DRB1
13 MHC class I protein complex GO:0042612 9.33 HLA-A HLA-B HLA-C
14 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.1 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DQB2 HLA-DRB1
15 endoplasmic reticulum GO:0005783 10.03 EGFR EPHX1 HLA-A HLA-B HLA-C HLA-DQB2

Biological processes related to Geographic Tongue according to GeneCards Suite gene sharing:

(show all 16)
id Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.89 BRD4 HLA-A HLA-B HLA-C HLA-DRB1
2 immune system process GO:0002376 9.8 CD79A HLA-A HLA-B HLA-C HLA-DQB2 HLA-DRB1
3 immune response GO:0006955 9.76 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DQB2 HLA-DRB1
4 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.73 HLA-DQB1 HLA-DQB2 HLA-DRB1
5 T cell costimulation GO:0031295 9.72 HLA-DQB1 HLA-DQB2 HLA-DRB1
6 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.71 HLA-A HLA-B HLA-C
7 type I interferon signaling pathway GO:0060337 9.7 HLA-A HLA-B HLA-C
8 positive regulation of epithelial cell proliferation GO:0050679 9.69 EGFR NME1 VEGFA
9 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.58 HLA-A HLA-B HLA-C
10 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.54 HLA-DQB1 HLA-DQB2 HLA-DRB1
11 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.5 HLA-A HLA-B HLA-C
12 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.48 HLA-DQB1 HLA-DRB1
13 protection from natural killer cell mediated cytotoxicity GO:0042270 9.46 HLA-A HLA-B
14 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.43 HLA-DQB1 HLA-DRB1
15 interferon-gamma-mediated signaling pathway GO:0060333 9.43 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DQB2 HLA-DRB1
16 antigen processing and presentation GO:0019882 9.1 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DQB2 HLA-DRB1

Molecular functions related to Geographic Tongue according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 MHC class II receptor activity GO:0032395 9.13 HLA-DQB1 HLA-DQB2 HLA-DRB1
2 peptide antigen binding GO:0042605 9.1 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DQB2 HLA-DRB1
Sources

Sources for Geographic Tongue

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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