MCID: GGR001
MIFTS: 52

Geographic Tongue

Categories: Rare diseases, Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Geographic Tongue

MalaCards integrated aliases for Geographic Tongue:

Name: Geographic Tongue 12 72 49 14
Glossitis, Benign Migratory 41 69
Benign Migratory Glossitis 12 49
Glossitis Areata Exfoliativa 12
Erythema Chronicum Migrans 69
Ectopic Geographic Tongue 49
Pityriasis Linguae 12
Erythema Migrans 49

Classifications:



External Ids:

Disease Ontology 12 DOID:1455
ICD10 32 K14.1
ICD9CM 34 529.1
MeSH 41 D005929
NCIt 46 C84588

Summaries for Geographic Tongue

NIH Rare Diseases : 49 Geographic tongue is a condition that causes chronic and recurrent lesions on the tongue that resemble psoriasis of the skin. It is characterized by pink to red, slightly depressed lesions with irregular, elevated, white or yellow borders. The lesions may also occur in the mucosa of the mouth and labia; this condition is called "areata migrans" because these lesions typically disappear from one area and show up in another. The tongue is normally covered with tiny, pinkish-white bumps (papillae), which are actually short, fine, hair-like projections. With geographic tongue, patches on the surface of the tongue are missing papillae and appear as smooth, red "islands," often with slightly raised borders. These patches (lesions) give the tongue a map-like, or geographic, appearance. In most cases there are no symptoms but sometimes it is painful when inflamed. The cause of this condition is unknown. Many researchers think it is linked with psoriasis, but more research is needed to better understand the connection. Also, hereditary and environmental factors may be involved. The condition is benign and localized, generally requiring no treatment except reassurance. If painful, it may be treated with steroid gels or antihistamine mouth rinses.  Last updated: 4/14/2016

MalaCards based summary : Geographic Tongue, also known as glossitis, benign migratory, is related to pustulosis of palm and sole and celiac disease 1, and has symptoms including glossalgia, heliotrope rash and erythema of the eyelids. An important gene associated with Geographic Tongue is IL36RN (Interleukin 36 Receptor Antagonist), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and Cytokine Signaling in Immune system. The drugs Doxycycline and Cefuroxime have been mentioned in the context of this disorder. Affiliated tissues include tongue, skin and testes, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Disease Ontology : 12 An atrophic glossitis that is characterized as an inflammatory condition of the mucous membrane of the tongue, usually on the dorsal surface.

Wikipedia : 72 Geographic tongue, also known by several other terms,[note 1] is an inflammatory condition of the mucous... more...

Related Diseases for Geographic Tongue

Diseases related to Geographic Tongue via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 123)
# Related Disease Score Top Affiliating Genes
1 pustulosis of palm and sole 30.3 IL36RN TNF
2 celiac disease 1 28.2 CD79A HLA-A HLA-DQB1 HLA-DQB2 TGM2 TNF
3 lyme disease 11.7
4 fissured tongue 11.5
5 limbic encephalitis with lgi1 antibodies 10.6 HLA-DQB1 HLA-DRB1
6 phenytoin or carbamazepine toxicity 10.5 HLA-A HLA-B
7 recurrent hypersomnia 10.5 HLA-DQB1 HLA-DQB2
8 metal allergy 10.5 HLA-DQB1 HLA-DRB1
9 focal epithelial hyperplasia 10.5 HLA-DQB1 HLA-DRB1
10 atrial tachyarrhythmia with short pr interval 10.4 HLA-A HLA-B
11 lichen planopilaris 10.4 HLA-DQB1 HLA-DRB1
12 type ii mixed cryoglobulinemia 10.4 HLA-DQB1 HLA-DRB1
13 postherpetic neuralgia 10.4 HLA-A HLA-B HLA-DRB1
14 pars planitis 10.3 HLA-A HLA-B HLA-DRB1
15 autoimmune hepatitis 10.3 HLA-A HLA-DQB1 HLA-DRB1
16 atrophic glossitis 10.3 HLA-A HLA-DQB2 IL36RN WHRN
17 glaucomatocyclitic crisis 10.3 HLA-A HLA-B HLA-C
18 idiopathic inflammatory myopathy 10.3 HLA-B HLA-DQB1 HLA-DRB1
19 histoplasmosis 10.3 HLA-A HLA-B HLA-DRB1
20 pure red-cell aplasia 10.3 HLA-A HLA-B HLA-DRB1
21 human herpesvirus 8 10.3 HLA-A HLA-B HLA-C
22 acrodermatitis 10.3
23 recurrent respiratory papillomatosis 10.2 EGFR HLA-DQB1 HLA-DRB1
24 acrodermatitis chronica atrophicans 10.2
25 beryllium disease 10.2 HLA-DQB1 HLA-DRB1 TNF
26 chronic beryllium disease 10.2 HLA-DQB1 HLA-DRB1 TNF
27 autoimmune pancreatitis 10.2 HLA-DQB1 HLA-DRB1 TNF
28 lichen sclerosus 10.2 HLA-DQB1 HLA-DRB1 TNF
29 dengue shock syndrome 10.2 HLA-A HLA-DRB1 TNF
30 vogt-koyanagi-harada disease 10.2 HLA-A HLA-B HLA-DQB1 HLA-DRB1
31 rheumatic heart disease 10.2 HLA-A HLA-DRB1 TNF
32 dengue hemorrhagic fever 10.2 HLA-A HLA-DRB1 TNF
33 oligoarticular juvenile idiopathic arthritis 10.2 HLA-DQB1 HLA-DRB1 TNF
34 severe hemophilia a 10.2 HLA-DQB1 HLA-DRB1 TNF
35 anterior uveitis 10.1 HLA-A HLA-B TNF
36 pustular psoriasis 10.1 IL36RN TNF
37 sympathetic ophthalmia 10.1 HLA-C HLA-DRB1 TNF
38 aphthous stomatitis 10.1 HLA-A HLA-B TNF
39 microscopic polyangiitis 10.1 HLA-B HLA-DRB1 TNF
40 severe cutaneous adverse reaction 10.1 EPHX1 HLA-A HLA-B HLA-C
41 cytomegalovirus retinitis 10.1 HLA-B HLA-DQB1 TNF
42 osteonecrosis of the jaw 10.1 HLA-DQB1 HLA-DRB1 VEGFA
43 melanoma, uveal 10.1 HLA-A HLA-B NME1
44 glossitis 10.1
45 psoriasis 10.1
46 cholangitis 10.0 HLA-B HLA-DRB1 TNF
47 rheumatic disease 10.0 HLA-B HLA-DRB1 TNF
48 myocarditis 10.0 HLA-B HLA-DQB1 TNF
49 spondylitis 10.0 HLA-B HLA-C TNF
50 juvenile dermatitis herpetiformis 10.0 CD79A HLA-A

Graphical network of the top 20 diseases related to Geographic Tongue:



Diseases related to Geographic Tongue

Symptoms & Phenotypes for Geographic Tongue

UMLS symptoms related to Geographic Tongue:


glossalgia, heliotrope rash, erythema of the eyelids, exanthema

GenomeRNAi Phenotypes related to Geographic Tongue according to GeneCards Suite gene sharing:

25 (show all 25)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.48 HLA-B HLA-C HLA-A
2 Increased shRNA abundance (Z-score > 2) GR00366-A-11 10.48 CD79A
3 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.48 HLA-B HLA-C HLA-A
4 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.48 HLA-B HLA-C HLA-A EGFR
5 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10.48 EGFR
6 Increased shRNA abundance (Z-score > 2) GR00366-A-124 10.48 HLA-C
7 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.48 HLA-C
8 Increased shRNA abundance (Z-score > 2) GR00366-A-156 10.48 HLA-B HLA-C HLA-A
9 Increased shRNA abundance (Z-score > 2) GR00366-A-162 10.48 HLA-C
10 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10.48 CD79A
11 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.48 HLA-B HLA-C HLA-A
12 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.48 HLA-B HLA-C HLA-A
13 Increased shRNA abundance (Z-score > 2) GR00366-A-190 10.48 EGFR
14 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.48 HLA-C
15 Increased shRNA abundance (Z-score > 2) GR00366-A-21 10.48 EGFR
16 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.48 EGFR
17 Increased shRNA abundance (Z-score > 2) GR00366-A-31 10.48 HLA-C HLA-B HLA-A
18 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.48 EGFR
19 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.48 HLA-C
20 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.48 CD79A
21 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.48 HLA-B HLA-C HLA-A
22 Increased shRNA abundance (Z-score > 2) GR00366-A-70 10.48 CD79A
23 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.48 HLA-B HLA-C HLA-A CD79A
24 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.48 EGFR
25 Increased shRNA abundance (Z-score > 2) GR00366-A-93 10.48 HLA-C

MGI Mouse Phenotypes related to Geographic Tongue:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.56 CD79A EGFR HLA-DQB1 NME1 THEM5 TNF
2 neoplasm MP:0002006 9.17 CD79A EGFR EPHX1 NME1 TGM2 TNF

Drugs & Therapeutics for Geographic Tongue

Drugs for Geographic Tongue (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
2
Cefuroxime Approved Phase 4 55268-75-2 5479529 5361202
3
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
4
Penicillin V Approved, Vet_approved Phase 4 87-08-1 6869
5 Anti-Bacterial Agents Phase 4,Phase 1,Phase 2
6 Anti-Infective Agents Phase 4,Phase 1,Phase 2
7 Antimalarials Phase 4
8 Antiparasitic Agents Phase 4
9 Antiprotozoal Agents Phase 4
10 cefuroxime axetil Phase 4
11 Antibiotics, Antitubercular Phase 4,Phase 1,Phase 2
12 penicillins Phase 4
13
Ceftriaxone Approved 73384-59-5 5479530 5361919
14 Antitubercular Agents
15 Antibodies
16 Immunoglobulins
17 Immunoglobulin A
18 Immunoglobulin M

Interventional clinical trials:

(show all 21)

# Name Status NCT ID Phase Drugs
1 Comparison of Doxycycline and Cefuroxime Axetil for Treatment of Erythema Migrans: Clinical and Microbiological Outcome Completed NCT01518192 Phase 4 doxycycline;cefuroxime axetil
2 Comparing 3 Antibiotic Regimes for Erythema Migrans in General Practice Completed NCT01368341 Phase 4 Doxycycline;Phenoxymethylpenicillin;Amoxicillin
3 Xenodiagnosis After Antibiotic Treatment for Lyme Disease Recruiting NCT02446626 Phase 1, Phase 2
4 The Relationship Between Allergic Rhinitis and Geographic Tongue Unknown status NCT01454492
5 Doxycycline and Ceftriaxone in Suspected Early Lyme Neuroborreliosis Unknown status NCT00942006 doxycycline;ceftriaxone
6 Doxycycline in Therapy of Erythema Migrans Completed NCT01475708 Doxycycline
7 Duration of Antibiotic Treatment of Erythema Migrans Completed NCT00910715 doxycycline;doxycycline;placebo
8 Culture Media for Borrelia Burgdorferi Sensu Lato Completed NCT02145754
9 Searching for Persistence of Infection in Lyme Disease Completed NCT01143558 Early Phase 1
10 Cytokines and Chemokines in Erythema Migrans Recruiting NCT02147249 antibiotic treatment
11 Antibiotic Treatment of Multiple Erythema Migrans Recruiting NCT01163994 ceftriaxone;doxycycline
12 Analysis of Lyme Disease Lesions Recruiting NCT00132327
13 Duration of Doxycycline Treatment in EM Patients Recruiting NCT03153267 Doxycycline 100 MG Oral Tablet bid, 7 days;Doxycycline 100 MG Oral Tablet bid, 14 days;Controls without a history of lyme disease.
14 Duration of Doxycycline Treatment in MEM Patients Recruiting NCT03337932 Doxycycline 100 milligram Oral Tablet bid, 7 days;Doxycycline 100 milligram Oral Tablet bid, 14 days;Controls without a history of lyme disease.
15 Lyme Borreliosis and Early Cutaneous Diagnostic Recruiting NCT02414789
16 Borrelia Species in Cutaneous Lyme Borreliosis Recruiting NCT00576082
17 Sofia 2 Lyme FIA Whole Blood Clinical Study Recruiting NCT03238274
18 Lyme Test Indication Combinations (LyTIC) Study Recruiting NCT03201042
19 Erythema Migrans in Elderly Active, not recruiting NCT03371563 Antibiotics
20 Investigation of Southern Tick-Associated Rash Illness (STARI) Terminated NCT00358761
21 A Multicenter Study to Evaluate a Borrelia Diagnostic Test in Subjects With Early Stage or Late Stage Lyme Disease Terminated NCT02741609

Search NIH Clinical Center for Geographic Tongue

Cochrane evidence based reviews: glossitis, benign migratory

Genetic Tests for Geographic Tongue

Anatomical Context for Geographic Tongue

MalaCards organs/tissues related to Geographic Tongue:

38
Tongue, Skin, Testes, Whole Blood

Publications for Geographic Tongue

Articles related to Geographic Tongue:

(show top 50) (show all 54)
# Title Authors Year
1
Geographic tongue: assessment of peripheral nerve status, Langerhans cell, and HLA-DR expression. ( 28757081 )
2017
2
Geographic Tongue. ( 28716459 )
2017
3
Salivary levels of interleukin-8 and growth factors are modulated in patients with geographic tongue. ( 28178402 )
2017
4
Lingual microbiota profiles of patients with geographic tongue. ( 28839519 )
2017
5
Investigation of the clinical features of geographic tongue: unveiling its relationship with oral psoriasis. ( 28188609 )
2017
6
IMAGES IN CLINICAL MEDICINE. Geographic Tongue. ( 26886524 )
2016
7
The prevalence of celiac disease in patients with geographic tongue. ( 27131886 )
2016
8
Geographic tongue associated with sialadenitis. ( 27726175 )
2016
9
Geographic Tongue. ( 27436616 )
2016
10
Paediatric Geographic Tongue: A Case Report, Review and Recent Updates. ( 27042597 )
2016
11
Geographic tongue and psoriasis: clinical, histopathological, immunohistochemical and genetic correlation - a literature review. ( 27579734 )
2016
12
Geographic tongue. ( 27505875 )
2016
13
Treatment of Symptomatic Geographic Tongue with Triamcinolone Acetonide Alone and in Combination with Retinoic Acid: A Randomized Clinical Trial. ( 27536325 )
2016
14
Oral medicine: Factors associated with geographic tongue and fissured tongue. ( 27388082 )
2016
15
Mutations in IL36RN are associated with geographic tongue. ( 27900482 )
2016
16
Prevalence of Geographic tongue and Related Predisposing Factors in 7-18 Year-Old Students in Kermanshah, Iran 2014. ( 26156909 )
2015
17
Psychological parameters associated with geographic tongue: a clinical observation. ( 25482551 )
2015
18
Geographic tongue and fissured tongue in 348 patients with psoriasis: correlation with disease severity. ( 25685842 )
2015
19
Psychological parameters associated with geographic tongue: a clinical observation. ( 25482552 )
2015
20
Factors associated with geographic tongue and fissured tongue. ( 26381370 )
2015
21
A possible relationship of human leucocyte antigens with psoriasis vulgaris and geographic tongue. ( 25176018 )
2014
22
Relation between psoriasis and geographic tongue. ( 25584342 )
2014
23
Treatment of geographic tongue with topical tacrolimus. ( 25085945 )
2014
24
Immunologic and psychologic parameters associated with geographic tongue. ( 24842481 )
2014
25
Medical image. A benign glossal lesion. Geographic tongue. ( 24929575 )
2014
26
Geographic tongue in monozygotic twins. ( 24959517 )
2014
27
Case of the month. Ectopic geographic tongue (erythema migrans). ( 24937889 )
2014
28
Geographic tongue and tenofovir. ( 23598934 )
2013
29
The comparison of salivary level of estrogen and progesterone in 1(st) , 2(nd) and 3(rd) trimester in pregnant women with and without geographic tongue. ( 24348617 )
2013
30
Geographic tongue induced by angiogenesis inhibitors. ( 23576484 )
2013
31
Geographic Tongue and Associated Risk Factors among Iranian Dental Patients. ( 23515238 )
2013
32
Oral and maxillofacial pathology case of the month. Erythema migrans (ectopic migratory glossitis/ectopic geographic tongue). ( 24236384 )
2013
33
Increased prevalence of geographic tongue in burning mouth complaints: a retrospective study. ( 22901641 )
2012
34
Migratory stomatitis (ectopic geographic tongue) on the floor of the mouth. ( 21763590 )
2011
35
Geographic tongue treated with topical tacrolimus. ( 21886753 )
2010
36
Allergic contact stomatitis presenting as geographical tongue with pruritus. ( 19207382 )
2009
37
Images in clinical medicine. Geographic tongue. ( 19907039 )
2009
38
Oral medicine case book 7. Migratory stomatitis and geographic tongue. ( 18689340 )
2008
39
Ectopic geographic tongue--a case report. ( 17432777 )
2007
40
Recurrent geographical tongue and fissured tongue in association with pregnancy. ( 17243991 )
2007
41
The prevalence and significance of fissured tongue and geographical tongue in psoriatic patients. ( 16487088 )
2006
42
Prevalence and risk factors associated with geographic tongue among US adults. ( 16792723 )
2006
43
Geographic tongue: literature review and case reports. ( 16161818 )
2005
44
Geographic tongue: clinical characteristics of 188 cases. ( 15719084 )
2005
45
Prevalence of fissured tongue, geographic tongue and median rhomboid glossitis among Israeli adults of different ethnic origins. ( 15316160 )
2004
46
Painful geographic tongue (benign migratory glossitis) in a child. ( 15482313 )
2004
47
Benign migratory glossitis or geographic tongue: an enigmatic oral lesion. ( 12517366 )
2002
48
Geographic tongue (migrant glossitis) and psoriasis. ( 11535977 )
2001
49
Melkersson - rosenthal syndrome with geographical tongue. ( 20944302 )
1997
50
Occurrence of fissured tongue, geographic tongue and filiform atrophy among dental patients in Saudi Arabia. ( 3867320 )
1985

Variations for Geographic Tongue

Expression for Geographic Tongue

Search GEO for disease gene expression data for Geographic Tongue.

Pathways for Geographic Tongue

Pathways related to Geographic Tongue according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.34 CD79A EGFR HLA-A HLA-B HLA-C HLA-DQB1
2
Show member pathways
13.17 EGFR HLA-A HLA-B HLA-C HLA-DQB1 HLA-DQB2
3
Show member pathways
12.9 EGFR HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1
4
Show member pathways
12.88 EGFR HLA-A HLA-B HLA-C TNF VEGFA
5
Show member pathways
12.54 CD79A HLA-DQB1 HLA-DQB2 HLA-DRB1 TNF
6
Show member pathways
12.45 HLA-A HLA-B HLA-C TNF VEGFA
7
Show member pathways
12.44 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1 TNF
8
Show member pathways
12.37 HLA-A HLA-B HLA-C TNF TNFRSF10B
9 12.29 EGFR HLA-A HLA-B HLA-C
10
Show member pathways
12.29 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DQB2 HLA-DRB1
11
Show member pathways
12.19 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1 TNF
12 12.14 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1
13
Show member pathways
12.02 HLA-A HLA-B HLA-C TNF
14 11.95 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1
15
Show member pathways
11.83 HLA-DQB1 HLA-DQB2 HLA-DRB1
16 11.83 EGFR HLA-DQB1 HLA-DQB2 HLA-DRB1
17 11.82 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1
18 11.8 HLA-DQB1 HLA-DQB2 HLA-DRB1
19 11.77 HLA-DQB1 HLA-DRB1 TNF
20 11.71 HLA-DQB1 HLA-DRB1 TNF VEGFA
21
Show member pathways
11.66 HLA-DQB1 HLA-DQB2 HLA-DRB1
22 11.51 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1 TNF
23 11.42 EGFR TNF VEGFA
24 11.05 HLA-A HLA-B HLA-C

GO Terms for Geographic Tongue

Cellular components related to Geographic Tongue according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 Golgi membrane GO:0000139 9.87 EGFR HLA-A HLA-B HLA-C HLA-DQB1 HLA-DQB2
2 endosome membrane GO:0010008 9.83 EGFR HLA-DQB1 HLA-DQB2 HLA-DRB1
3 cell surface GO:0009986 9.76 EGFR HLA-A HLA-B HLA-C HLA-DRB1 TNF
4 trans-Golgi network membrane GO:0032588 9.73 HLA-DQB1 HLA-DQB2 HLA-DRB1
5 phagocytic vesicle membrane GO:0030670 9.71 HLA-A HLA-B HLA-C
6 early endosome membrane GO:0031901 9.71 EGFR HLA-A HLA-B HLA-C
7 recycling endosome membrane GO:0055038 9.69 HLA-A HLA-B HLA-C
8 endocytic vesicle membrane GO:0030666 9.67 HLA-DQB1 HLA-DQB2 HLA-DRB1
9 transport vesicle membrane GO:0030658 9.65 HLA-DQB1 HLA-DQB2 HLA-DRB1
10 clathrin-coated endocytic vesicle membrane GO:0030669 9.63 HLA-DQB1 HLA-DQB2 HLA-DRB1
11 MHC class II protein complex GO:0042613 9.54 HLA-DQB1 HLA-DQB2 HLA-DRB1
12 MHC class I protein complex GO:0042612 9.43 HLA-A HLA-B HLA-C
13 ER to Golgi transport vesicle membrane GO:0012507 9.43 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DQB2 HLA-DRB1
14 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.1 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DQB2 HLA-DRB1
15 plasma membrane GO:0005886 10.33 AKTIP CD79A EGFR HLA-A HLA-B HLA-C
16 endoplasmic reticulum GO:0005783 10.03 EGFR EPHX1 HLA-A HLA-B HLA-C HLA-DQB2

Biological processes related to Geographic Tongue according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.87 CD79A HLA-A HLA-B HLA-C HLA-DQB2 HLA-DRB1
2 immune response GO:0006955 9.81 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DQB2 HLA-DRB1
3 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.77 HLA-DQB1 HLA-DQB2 HLA-DRB1
4 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.76 EGFR TNF VEGFA
5 positive regulation of protein phosphorylation GO:0001934 9.76 AKTIP EGFR TNF VEGFA
6 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.75 HLA-A HLA-B HLA-C
7 T cell costimulation GO:0031295 9.74 HLA-DQB1 HLA-DQB2 HLA-DRB1
8 type I interferon signaling pathway GO:0060337 9.73 HLA-A HLA-B HLA-C
9 positive regulation of epithelial cell proliferation GO:0050679 9.72 EGFR NME1 VEGFA
10 positive regulation of MAP kinase activity GO:0043406 9.71 EGFR TNF VEGFA
11 positive regulation of smooth muscle cell proliferation GO:0048661 9.7 EGFR TGM2 TNF
12 positive regulation of cell adhesion GO:0045785 9.65 TGM2 TNF VEGFA
13 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.58 HLA-A HLA-B HLA-C
14 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.54 HLA-DQB1 HLA-DQB2 HLA-DRB1
15 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.51 HLA-DQB1 HLA-DRB1
16 protection from natural killer cell mediated cytotoxicity GO:0042270 9.49 HLA-A HLA-B
17 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.43 HLA-DQB1 HLA-DRB1
18 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.43 HLA-A HLA-B HLA-C
19 interferon-gamma-mediated signaling pathway GO:0060333 9.43 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DQB2 HLA-DRB1
20 antigen processing and presentation GO:0019882 9.1 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DQB2 HLA-DRB1

Molecular functions related to Geographic Tongue according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MHC class II receptor activity GO:0032395 9.13 HLA-DQB1 HLA-DQB2 HLA-DRB1
2 peptide antigen binding GO:0042605 9.02 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1

Sources for Geographic Tongue

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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