MCID: GRM001
MIFTS: 26

Germ Cell and Embryonal Cancer

Categories: Cancer diseases, Fetal diseases

Aliases & Classifications for Germ Cell and Embryonal Cancer

MalaCards integrated aliases for Germ Cell and Embryonal Cancer:

Name: Germ Cell and Embryonal Cancer 12 14
Neoplasms, Germ Cell and Embryonal 41
Germ Cell and Embryonal Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3095
MeSH 41 D009373
UMLS 69 C0027658

Summaries for Germ Cell and Embryonal Cancer

Disease Ontology : 12 A germ cell cancer that is derives from a mixture of germs cells and embryonal cells.

MalaCards based summary : Germ Cell and Embryonal Cancer, also known as neoplasms, germ cell and embryonal, is related to teratoma and trophoblastic neoplasm. An important gene associated with Germ Cell and Embryonal Cancer is POU5F1 (POU Class 5 Homeobox 1), and among its related pathways/superpathways are Wnt Signaling Pathway and Pluripotency and Mesodermal Commitment Pathway. Related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Germ Cell and Embryonal Cancer

Diseases related to Germ Cell and Embryonal Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Related Disease Score Top Affiliating Genes
1 teratoma 31.8 AFP KRT7 MNX1 POU5F1 SOX2
2 trophoblastic neoplasm 31.7 CDKN1C CSH1 KHDC3L NLRP7 PAM
3 partial hydatidiform mole 10.6 KHDC3L NLRP7
4 extragonadal germ cell cancer 10.5 AFP POU5F1
5 sacrococcygeal teratoma 10.5 AFP MNX1
6 central nervous system germ cell tumor 10.5 AFP POU5F1 SOX2
7 embryonal testis carcinoma 10.5 AFP POU5F1
8 mature teratoma 10.5 AFP ANO6 POU5F1
9 intrahepatic bile duct adenoma 10.5 AFP KRT7
10 childhood endodermal sinus tumor 10.5 AFP LIN28A
11 triploidy 10.5 AFP KHDC3L NLRP7
12 hepatic angiomyolipoma 10.5 AFP MYC
13 malignant teratoma 10.4 AFP POU5F1 TG
14 gallbladder signet ring cell adenocarcinoma 10.4 KRT7 MYC
15 testicular trophoblastic tumor 10.4 CSH1 CSH2
16 intratubular embryonal carcinoma 10.4 AFP KRT7 POU5F1
17 hydatidiform mole, recurrent, 1 10.4 CDKN1C KHDC3L NLRP7
18 ocular cancer 10.4 MYC POU5F1 SOX2
19 omphalocele 10.4 AFP CDKN1C MNX1
20 epithelioid trophoblastic tumor 10.3 CSH1 KRT7
21 bile duct cystadenocarcinoma 10.3 AFP KRT7
22 ovarian germ cell teratoma 10.3 KRT7 TG
23 sex cord-gonadal stromal tumor 10.3 AFP ANO6 KRT7
24 malignant struma ovarii 10.3 AFP TG
25 malignant leydig cell tumor 10.3 KRT7 POU5F1
26 ovarian germ cell cancer 10.3 AFP KRT7 TG
27 choriocarcinoma of ovary 10.3 CSH1 CSH2
28 testicular granulosa cell tumor 10.3 AFP CSH1 CSH2
29 juvenile type testicular granulosa cell tumor 10.3 AFP CSH1 CSH2
30 cystadenofibroma 10.3 AFP KRT7 TG
31 rh isoimmunization 10.3 AFP CSH1 CSH2
32 liver lymphoma 10.3 AFP FUT4
33 uterine anomalies 10.2 AFP CSH1 CSH2
34 hepatoblastoma 10.2 AFP CDKN1C KRT7
35 sternum cancer 10.2 AFP FUT4
36 placenta disease 10.2 AFP CSH1 CSH2
37 gastrointestinal system cancer 10.2 AFP KRT7 MYC
38 ovarian embryonal carcinoma 10.2 AFP NANOG POU5F1 SOX2
39 extragonadal seminoma 10.2 AFP NANOG POU5F1 SOX2
40 renal pelvis carcinoma 10.2 AFP KRT7
41 testicular infarct 10.2 AFP FUT4 POU5F1
42 mixed germ cell cancer 10.2 AFP FUT4 POU5F1
43 brain germinoma 10.2 AFP FUT4 POU5F1
44 non-gestational choriocarcinoma 10.1 CSH1 CSH2
45 adenomatoid tumor 10.1 AFP KRT7
46 choriocarcinoma 10.1 CDKN1C CSH1 CSH2
47 cell type cancer 10.0 AFP KRT7 MYC POU5F1 SOX2
48 choriocarcinoma of the testis 10.0 AFP CSH1 CSH2 KRT7
49 nodular hidradenoma 10.0 FUT4 KRT7
50 secretory meningioma 10.0 FUT4 KLF4 KRT7

Graphical network of the top 20 diseases related to Germ Cell and Embryonal Cancer:



Diseases related to Germ Cell and Embryonal Cancer

Symptoms & Phenotypes for Germ Cell and Embryonal Cancer

GenomeRNAi Phenotypes related to Germ Cell and Embryonal Cancer according to GeneCards Suite gene sharing:

25 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.47 AFP
2 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.47 AFP
3 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.47 POU5F1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.47 POU5F1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.47 KRT7
6 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.47 POU5F1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.47 AFP KRT7 POU5F1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.47 AFP
9 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.47 POU5F1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.47 AFP
11 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.47 KRT7 POU5F1

Drugs & Therapeutics for Germ Cell and Embryonal Cancer

Search Clinical Trials , NIH Clinical Center for Germ Cell and Embryonal Cancer

Cochrane evidence based reviews: neoplasms, germ cell and embryonal

Genetic Tests for Germ Cell and Embryonal Cancer

Anatomical Context for Germ Cell and Embryonal Cancer

Publications for Germ Cell and Embryonal Cancer

Variations for Germ Cell and Embryonal Cancer

Expression for Germ Cell and Embryonal Cancer

Search GEO for disease gene expression data for Germ Cell and Embryonal Cancer.

Pathways for Germ Cell and Embryonal Cancer

GO Terms for Germ Cell and Embryonal Cancer

Biological processes related to Germ Cell and Embryonal Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription by RNA polymerase II GO:0006366 9.85 KLF4 MYC NANOG POU5F1 SOX2
2 regulation of gene expression GO:0010468 9.62 MYC NANOG POU5F1 SOX2
3 response to wounding GO:0009611 9.54 MYC POU5F1 SOX2
4 response to growth factor GO:0070848 9.43 MYC SOX2
5 stem cell population maintenance GO:0019827 9.43 KLF4 LIN28A NANOG
6 hormone biosynthetic process GO:0042446 9.4 DIO3 TG
7 cellular response to cycloheximide GO:0071409 9.16 KLF4 MYC
8 endodermal cell fate specification GO:0001714 9.13 NANOG POU5F1 SOX2
9 somatic stem cell population maintenance GO:0035019 9.02 KLF4 LIN28A NANOG POU5F1 SOX2

Molecular functions related to Germ Cell and Embryonal Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding transcription factor activity GO:0003700 9.73 KLF4 MNX1 MYC NANOG POU5F1 SOX2
2 sequence-specific DNA binding GO:0043565 9.43 KLF4 MNX1 MYC NANOG POU5F1 SOX2
3 hormone activity GO:0005179 9.33 CSH1 CSH2 TG
4 miRNA binding GO:0035198 8.8 LIN28A POU5F1 SOX2

Sources for Germ Cell and Embryonal Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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